9925:VAX1
gene id: 9925:VAX1
uniprot id: A0A452DMM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

9925:MAS1
gene id: 9925:MAS1
uniprot id: A0A452EEQ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:CNTF
gene id: 9925:CNTF
uniprot id: A0A452E586
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9925:MDH2
gene id: 9925:MDH2
uniprot id: A0A452FXX0
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

9925:CLIC6
gene id: 9925:CLIC6
uniprot id: A0A452EVK4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9925:ATG4C
gene id: 9925:ATG4C
uniprot id: A0A452FYP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9925:TACC1
gene id: 9925:TACC1
uniprot id: A0A452FYM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9925:CSAD
gene id: 9925:CSAD
uniprot id: A0A452G6X6
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9925:CAMK2B
gene id: 9925:CAMK2B
uniprot id: A0A452FS38
uniprot id: A0A452FS53
uniprot id: A0A452FS64
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9925:NME7
gene id: 9925:NME7
uniprot id: A0A452E1D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9925:LOC102178162
gene id: 9925:LOC102178162
uniprot id: A0A452F0G7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9925:FBXO45
gene id: 9925:FBXO45
uniprot id: A0A452G9A7
names: Similarity
messages: Belongs to the FBXO45/Fsn family.

9925:HS3ST1
gene id: 9925:HS3ST1
uniprot id: A0A452DQN3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:GRAP2
gene id: 9925:GRAP2
uniprot id: A0A452EQX1
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9925:CELF5
gene id: 9925:CELF5
uniprot id: A0A452DQ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9925:LANCL2
gene id: 9925:LANCL2
uniprot id: A0A452EVJ6
names: Similarity
messages: Belongs to the LanC-like protein family.

9925:LOC102172159
gene id: 9925:LOC102172159
uniprot id: A0A452ECF0
names: Similarity
messages: Belongs to the Bcl-2 family.

9925:GOSR2
gene id: 9925:GOSR2
uniprot id: A0A452ET48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9925:DDX18
gene id: 9925:DDX18
uniprot id: A0A452F8X7
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

9925:TOMM5
gene id: 9925:TOMM5
uniprot id: A0A452FNQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:LOC102181552
gene id: 9925:LOC102181552
uniprot id: A0A452F068
names: Similarity
messages: Belongs to the serpin family.

9925:DNAAF2
gene id: 9925:DNAAF2
uniprot id: A0A452EXP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

9925:NAE1
gene id: 9925:NAE1
uniprot id: A0A452DZC9
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

9925:VGLL3
gene id: 9925:VGLL3
uniprot id: A0A8C2N7R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9925:PMS2
gene id: 9925:PMS2
uniprot id: A0A452EY80
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9925:AKIRIN2
gene id: 9925:AKIRIN2
uniprot id: A0A8C2NIV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9925:FAM26D
gene id: 9925:FAM26D
uniprot id: A0A452DS11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9925:YAF2
gene id: 9925:YAF2
uniprot id: A0A452G561
uniprot id: A0A452G5B5
names: Subcellular Location Annotation
messages: Nucleus

9925:WDR82
gene id: 9925:WDR82
uniprot id: A0A452FJC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9925:MS4A10
gene id: 9925:MS4A10
uniprot id: A0A452DZL5
names: Similarity
messages: Belongs to the MS4A family.

9925:PRDM1
gene id: 9925:PRDM1
uniprot id: A0A452FSZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9925:SDR42E1
gene id: 9925:SDR42E1
uniprot id: A0A452FPN8
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9925:RBFOX3
gene id: 9925:RBFOX3
uniprot id: A0A452DZ45
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9925:DOK2
gene id: 9925:DOK2
uniprot id: A0A452FK51
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9925:HSP70.1
gene id: 9925:HSP70.1
uniprot id: C5IZH4
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9925:WNT2B
gene id: 9925:WNT2B
uniprot id: A0A452DYJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:HOXB13
gene id: 9925:HOXB13
uniprot id: A0A452G8N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:LOC102185449
gene id: 9925:LOC102185449
uniprot id: A0A452EQ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9925:ATP5B
gene id: 9925:ATP5B
uniprot id: A0A452E573
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9925:PIK3C3
gene id: 9925:PIK3C3
uniprot id: A0A452ERG8
uniprot id: A0A452ERQ4
uniprot id: A0A452ERU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

9925:PELI1
gene id: 9925:PELI1
uniprot id: A0A452FM66
uniprot id: A0A8C2QSV9
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9925:KCNT1
gene id: 9925:KCNT1
uniprot id: A0A452DVA6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:LOC102177790
gene id: 9925:LOC102177790
uniprot id: A0A452DZJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:IFI6
gene id: 9925:IFI6
uniprot id: A0A452F2E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9925:AP3S1
gene id: 9925:AP3S1
uniprot id: A0A452DPL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9925:UST
gene id: 9925:UST
uniprot id: A0A452E8G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9925:MTFP1
gene id: 9925:MTFP1
uniprot id: A0A452EEB6
names: Similarity
messages: Belongs to the MTFP1 family.

9925:ARF4
gene id: 9925:ARF4
uniprot id: A0A452DS03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:MCHR1
gene id: 9925:MCHR1
uniprot id: A0A452FQ31
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

9925:PDE6G
gene id: 9925:PDE6G
uniprot id: A0A452EUI3
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9925:STAMBPL1
gene id: 9925:STAMBPL1
uniprot id: A0A452E7N6
names: Similarity
messages: Belongs to the peptidase M67C family.

9925:SLC30A5
gene id: 9925:SLC30A5
uniprot id: A0A452FKW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9925:RNASE2
gene id: 9925:RNASE2
uniprot id: A0A452DTN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9925:CLRN2
gene id: 9925:CLRN2
uniprot id: A0A452FK30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9925:CD320
gene id: 9925:CD320
uniprot id: A0A2L1FDV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SLC25A45
gene id: 9925:SLC25A45
uniprot id: A0A452ERJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:NDST1
gene id: 9925:NDST1
uniprot id: A0A452EZE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9925:PPIF
gene id: 9925:PPIF
uniprot id: A0A452DKJ7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9925:ORC5
gene id: 9925:ORC5
uniprot id: A0A452EXP4
names: Subcellular Location Annotation
messages: Nucleus

9925:CGA
gene id: 9925:CGA
uniprot id: A0A452F3Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9925:RNF7
gene id: 9925:RNF7
uniprot id: A0A452EG83
names: Similarity
messages: Belongs to the RING-box family.

9925:DCT
gene id: 9925:DCT
uniprot id: A0A452DWF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9925:EMC7
gene id: 9925:EMC7
uniprot id: A0A452FE61
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

9925:MMP12
gene id: 9925:MMP12
uniprot id: A0A452G894
names: Similarity
messages: Belongs to the peptidase M10A family.

9925:SMC4
gene id: 9925:SMC4
uniprot id: A0A452F7D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

9925:MLST8
gene id: 9925:MLST8
uniprot id: A0A452DRC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9925:IDO2
gene id: 9925:IDO2
uniprot id: A0A452G1X3
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9925:SART3
gene id: 9925:SART3
uniprot id: A0A452FI92
names: Subcellular Location Annotation
messages: nucleoplasm

9925:UBN1
gene id: 9925:UBN1
uniprot id: A0A452FWD1
names: Similarity
messages: Belongs to the ubinuclein family.

9925:ANXA3
gene id: 9925:ANXA3
uniprot id: A0A452E8X0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9925:B3GNT9
gene id: 9925:B3GNT9
uniprot id: A0A8C2PJY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:EIF2AK3
gene id: 9925:EIF2AK3
uniprot id: A0A452EN74
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9925:VPS37C
gene id: 9925:VPS37C
uniprot id: A0A452EV72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9925:PIGK
gene id: 9925:PIGK
uniprot id: A0A452DNS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

9925:ADAMTS12
gene id: 9925:ADAMTS12
uniprot id: A0A452FEI8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:CANX
gene id: 9925:CANX
uniprot id: A0A452DM15
names: Similarity
messages: Belongs to the calreticulin family.

9925:SLC5A8
gene id: 9925:SLC5A8
uniprot id: A0A452EES5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9925:LOX
gene id: 9925:LOX
uniprot id: A0A452EY86
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9925:MELTF
gene id: 9925:MELTF
uniprot id: A0A452FXA9
names: Similarity
messages: Belongs to the transferrin family.

9925:WTAP
gene id: 9925:WTAP
uniprot id: A0A452G7K8
names: Similarity
messages: Belongs to the fl(2)d family.

9925:BAC5
gene id: 9925:BAC5
uniprot id: P82018
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: BAC5 sequence consists almost exclusively of X-P-P-Y repeats.
messages: Belongs to the cathelicidin family.
messages: Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Shows a potent antimicrobial activity against the Gram-negative bacteria E.coli, S.typhimurium and P.aeruginosa. Less active against the Gram-positive bacteria S.aureus, L.monocytogenes and B.subtilis.
messages: Elastase is responsible for its maturation.
messages: Secreted

9925:MALL
gene id: 9925:MALL
uniprot id: A0A452EHR8
names: Subcellular Location Annotation
messages: Membrane

9925:FGFR1
gene id: 9925:FGFR1
uniprot id: A0A452E6E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9925:SMARCA5
gene id: 9925:SMARCA5
uniprot id: A0A452EIB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9925:LOC102185863
gene id: 9925:LOC102185863
uniprot id: A0A452DU68
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TRUB1
gene id: 9925:TRUB1
uniprot id: A0A452FGD3
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9925:SCNN1G
gene id: 9925:SCNN1G
uniprot id: A0A452F5L2
names: Subcellular Location Annotation
messages: Membrane

9925:ADSSL1
gene id: 9925:ADSSL1
uniprot id: A0A452F4G4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9925:LOC102188159
gene id: 9925:LOC102188159
uniprot id: A0A452EB20
uniprot id: A0A8C2RF45
uniprot id: A0A8C2RH72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Membrane

9925:HOXC9
gene id: 9925:HOXC9
uniprot id: A0A452ESK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9925:METAP1D
gene id: 9925:METAP1D
uniprot id: A0A452DRZ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9925:CAMK2A
gene id: 9925:CAMK2A
uniprot id: A0A452G1X0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9925:EEF2
gene id: 9925:EEF2
uniprot id: A0A452EIR1
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

9925:LOC102177219
gene id: 9925:LOC102177219
uniprot id: A0A452DVG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:HSPB8
gene id: 9925:HSPB8
uniprot id: A0A452ESM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9925:ATAD2
gene id: 9925:ATAD2
uniprot id: A0A452FKH6
names: Similarity
messages: Belongs to the AAA ATPase family.

9925:CLIC1
gene id: 9925:CLIC1
uniprot id: A0A452FXD6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9925:GCK
gene id: 9925:GCK
uniprot id: A0A452ERT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9925:TYSND1
gene id: 9925:TYSND1
uniprot id: A0A452DKU6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

9925:LOC102181861
gene id: 9925:LOC102181861
uniprot id: A0A452EH91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:C24H18orf32
gene id: 9925:C24H18orf32
uniprot id: A0A452FHQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

9925:HNMT
gene id: 9925:HNMT
uniprot id: A0A452E323
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9925:LOC102175500
gene id: 9925:LOC102175500
uniprot id: A0A452F1T9
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9925:ZFPL1
gene id: 9925:ZFPL1
uniprot id: A0A8C2XXE7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

9925:LMOD2
gene id: 9925:LMOD2
uniprot id: A0A452FVX8
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9925:SERP1
gene id: 9925:SERP1
uniprot id: W6CGL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9925:NEURL2
gene id: 9925:NEURL2
uniprot id: A0A452FSZ8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:BICC1
gene id: 9925:BICC1
uniprot id: A0A452E118
names: Similarity
messages: Belongs to the BicC family.

9925:XRCC1
gene id: 9925:XRCC1
uniprot id: A0A452FF47
names: Subcellular Location Annotation
messages: Nucleus

9925:THRB
gene id: 9925:THRB
uniprot id: A0A452FL59
uniprot id: A0A452FLN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9925:CCDC94
gene id: 9925:CCDC94
uniprot id: A0A452EXZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

9925:EML4
gene id: 9925:EML4
uniprot id: A0A452F0E0
uniprot id: A0A452F0H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9925:UBALD1
gene id: 9925:UBALD1
uniprot id: A0A452DSD7
names: Similarity
messages: Belongs to the UBALD family.

9925:QRFPR
gene id: 9925:QRFPR
uniprot id: A0A452G889
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9925:MALSU1
gene id: 9925:MALSU1
uniprot id: A0A452FT39
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9925:LOC102173049
gene id: 9925:LOC102173049
uniprot id: A0A452E2R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9925:IZUMO1R
gene id: 9925:IZUMO1R
uniprot id: A0A452GAF9
names: Similarity
messages: Belongs to the folate receptor family.

9925:IRF2
gene id: 9925:IRF2
uniprot id: A0A452F0Z4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:WNT5B
gene id: 9925:WNT5B
uniprot id: A0A452ELI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:HOXD10
gene id: 9925:HOXD10
uniprot id: A0A452E9H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:FGFR1OP
gene id: 9925:FGFR1OP
uniprot id: A0A452FUY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9925:ACAD8
gene id: 9925:ACAD8
uniprot id: A0A452E8J9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9925:CDKN1A
gene id: 9925:CDKN1A
uniprot id: A0A452DS08
names: Similarity
messages: Belongs to the CDI family.

9925:LOC102190537
gene id: 9925:LOC102190537
uniprot id: A0A452G3Y8
uniprot id: A0A8C2RUI3
names: Similarity
messages: Belongs to the MHC class I family.

9925:GRPEL1
gene id: 9925:GRPEL1
uniprot id: A0A452G6S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9925:TDO2
gene id: 9925:TDO2
uniprot id: A0A452DME1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SNRPE
gene id: 9925:SNRPE
uniprot id: A0A452FW53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9925:KEF96 p03
gene id: 9925:KEF96_p03
uniprot id: E0XJX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9925:SPIRE2
gene id: 9925:SPIRE2
uniprot id: A0A452F9M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

9925:LOC102172432
gene id: 9925:LOC102172432
uniprot id: A0A452E3H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9925:PCMT1
gene id: 9925:PCMT1
uniprot id: A0A452G4A6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9925:HARBI1
gene id: 9925:HARBI1
uniprot id: A0A452EKN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9925:NECAP1
gene id: 9925:NECAP1
uniprot id: A0A452EAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9925:PPARG
gene id: 9925:PPARG
uniprot id: H6WNB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9925:UBE2B
gene id: 9925:UBE2B
uniprot id: A0A452F1F4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:NAV2
gene id: 9925:NAV2
uniprot id: A0A452DM61
uniprot id: A0A452DM65
uniprot id: A0A452DM74
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9925:LOC102183964
gene id: 9925:LOC102183964
uniprot id: A0A452DRZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FDXR
gene id: 9925:FDXR
uniprot id: A0A452EV68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

9925:PDE5A
gene id: 9925:PDE5A
uniprot id: A0A452FSF1
uniprot id: A0A452FSL9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:POLR2G
gene id: 9925:POLR2G
uniprot id: A0A8C2PM77
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

9925:ADCY4
gene id: 9925:ADCY4
uniprot id: A0A452FG15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9925:RPS10
gene id: 9925:RPS10
uniprot id: A5JST4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9925:DTX1
gene id: 9925:DTX1
uniprot id: A0A452F5Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9925:LTN1
gene id: 9925:LTN1
uniprot id: A0A452F206
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

9925:MAST1
gene id: 9925:MAST1
uniprot id: A0A452EAR8
uniprot id: A0A452EAX4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9925:CLVS2
gene id: 9925:CLVS2
uniprot id: A0A452FSQ9
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9925:RRM2B
gene id: 9925:RRM2B
uniprot id: A0A452FNR8
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

9925:FYTTD1
gene id: 9925:FYTTD1
uniprot id: A0A452FHL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

9925:LOC102185625
gene id: 9925:LOC102185625
uniprot id: A0A452DU84
names: Similarity
messages: Belongs to the EXO5 family.

9925:LOC102181962
gene id: 9925:LOC102181962
uniprot id: A0A452EHF7
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9925:TMEM131
gene id: 9925:TMEM131
uniprot id: A0A452FX59
names: Similarity
messages: Belongs to the TMEM131 family.

9925:ASF1A
gene id: 9925:ASF1A
uniprot id: A0A452DX55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9925:CA11
gene id: 9925:CA11
uniprot id: A0A452FTK2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9925:B3GNT4
gene id: 9925:B3GNT4
uniprot id: A0A452DYM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:POT1
gene id: 9925:POT1
uniprot id: A0A452ENH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9925:CRHBP
gene id: 9925:CRHBP
uniprot id: A0A452FX32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9925:LOC102168550
gene id: 9925:LOC102168550
uniprot id: A0A452DQS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NR1D2
gene id: 9925:NR1D2
uniprot id: A0A452EI43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:CXXC1
gene id: 9925:CXXC1
uniprot id: A0A452ELB7
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102182294
gene id: 9925:LOC102182294
uniprot id: A0A452DL40
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9925:E2F6
gene id: 9925:E2F6
uniprot id: A0A8C2Y297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9925:GDF11
gene id: 9925:GDF11
uniprot id: A0A452DM24
names: Similarity
messages: Belongs to the TGF-beta family.

9925:SLC41A2
gene id: 9925:SLC41A2
uniprot id: A0A452DRK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9925:RIN1
gene id: 9925:RIN1
uniprot id: A0A452G250
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9925:SCNN1A
gene id: 9925:SCNN1A
uniprot id: A0A452DZR4
names: Subcellular Location Annotation
messages: Membrane

9925:S100A7A
gene id: 9925:S100A7A
uniprot id: A0A452FKU3
names: Similarity
messages: Belongs to the S-100 family.

9925:SLC35B2
gene id: 9925:SLC35B2
uniprot id: A0A452F336
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9925:APOM
gene id: 9925:APOM
uniprot id: A0A452DQJ9
uniprot id: A0A8C2RS10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9925:KLC3
gene id: 9925:KLC3
uniprot id: A0A452G729
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9925:SYNGR3
gene id: 9925:SYNGR3
uniprot id: A0A452EWR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9925:ZUFSP
gene id: 9925:ZUFSP
uniprot id: A0A452FR06
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9925:ZC3H15
gene id: 9925:ZC3H15
uniprot id: A0A8C2PMZ5
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9925:COQ7
gene id: 9925:COQ7
uniprot id: A0A452EGI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9925:CLDN3
gene id: 9925:CLDN3
uniprot id: A0A452DQ99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:RORA
gene id: 9925:RORA
uniprot id: A0A452G4H9
uniprot id: E2GIP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9925:S100A1
gene id: 9925:S100A1
uniprot id: A0A452EA51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Mitochondrion

9925:SDHD
gene id: 9925:SDHD
uniprot id: D3JYV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9925:HCN3
gene id: 9925:HCN3
uniprot id: A0A452F198
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9925:STK38L
gene id: 9925:STK38L
uniprot id: A0A452EP22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Cytoplasm

9925:HMX1
gene id: 9925:HMX1
uniprot id: A0A452EAN7
names: Subcellular Location Annotation
messages: Nucleus

9925:TRMU
gene id: 9925:TRMU
uniprot id: A0A452EYJ2
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

9925:NCBP3
gene id: 9925:NCBP3
uniprot id: A0A452DYK7
names: Similarity
messages: Belongs to the NCBP3 family.

9925:TMEM11
gene id: 9925:TMEM11
uniprot id: A0A8C2P825
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

9925:NUP85
gene id: 9925:NUP85
uniprot id: A0A452F1M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9925:CHMP4B
gene id: 9925:CHMP4B
uniprot id: A0A452EQ33
names: Similarity
messages: Belongs to the SNF7 family.

9925:SLC12A6
gene id: 9925:SLC12A6
uniprot id: A0A452E6L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9925:EAF1
gene id: 9925:EAF1
uniprot id: A0A452G083
names: Similarity
messages: Belongs to the EAF family.

9925:COPG2
gene id: 9925:COPG2
uniprot id: A0A452E3J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9925:LOC102177517
gene id: 9925:LOC102177517
uniprot id: A0A452G821
names: Similarity
messages: Belongs to the intermediate filament family.

9925:ECHDC1
gene id: 9925:ECHDC1
uniprot id: A0A452DNY1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9925:XPO7
gene id: 9925:XPO7
uniprot id: A0A452EX93
uniprot id: A0A452EX96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9925:LOC102173702
gene id: 9925:LOC102173702
uniprot id: A0A452DX94
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9925:ANKZF1
gene id: 9925:ANKZF1
uniprot id: A0A452FQ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

9925:LOC102182773
gene id: 9925:LOC102182773
uniprot id: A0A452EBG6
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9925:ARSG
gene id: 9925:ARSG
uniprot id: A0A452E4W0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9925:MTCH2
gene id: 9925:MTCH2
uniprot id: A0A452EDM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:COQ6
gene id: 9925:COQ6
uniprot id: A0A452DM84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

9925:MAT2B
gene id: 9925:MAT2B
uniprot id: A0A452GAJ0
uniprot id: A0A452GAQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9925:SPESP1
gene id: 9925:SPESP1
uniprot id: A0A452EFP3
names: Function
names: Similarity
messages: Belongs to the SPESP1 family.
messages: Involved in fertilization ability of sperm.

9925:WASF2
gene id: 9925:WASF2
uniprot id: A0A452FUG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9925:SFR1
gene id: 9925:SFR1
uniprot id: A0A452FDB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9925:SPTBN4
gene id: 9925:SPTBN4
uniprot id: A0A452EPS0
names: Similarity
messages: Belongs to the spectrin family.

9925:CPEB2
gene id: 9925:CPEB2
uniprot id: A0A452FP70
uniprot id: A0A452FPA2
names: Similarity
messages: Belongs to the RRM CPEB family.

9925:ATG7
gene id: 9925:ATG7
uniprot id: A0A452F6K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

9925:FBXL5
gene id: 9925:FBXL5
uniprot id: A0A452E6F4
names: Subcellular Location Annotation
messages: perinuclear region

9925:IER2
gene id: 9925:IER2
uniprot id: A0A452DVD0
names: Similarity
messages: Belongs to the IER family.

9925:ADRA2A
gene id: 9925:ADRA2A
uniprot id: A0A452DNK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:RPL27
gene id: 9925:RPL27
uniprot id: A0A452FA73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9925:B9D2
gene id: 9925:B9D2
uniprot id: A0A452FVZ5
names: Subcellular Location Annotation
messages: cilium basal body

9925:PRIMPOL
gene id: 9925:PRIMPOL
uniprot id: A0A452EUL5
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9925:GATB
gene id: 9925:GATB
uniprot id: A0A452FCI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9925:CAMK2N1
gene id: 9925:CAMK2N1
uniprot id: A0A452EFL6
names: Similarity
messages: Belongs to the CAMK2N family.

9925:LOC102171886
gene id: 9925:LOC102171886
uniprot id: A0A452DZ24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MOK
gene id: 9925:MOK
uniprot id: A0A452EDK5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:ACHE
gene id: 9925:ACHE
uniprot id: A0A452FAM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9925:KCNN3
gene id: 9925:KCNN3
uniprot id: A0A452F4J8
names: Subcellular Location Annotation
messages: Membrane

9925:PACSIN2
gene id: 9925:PACSIN2
uniprot id: A0A452E625
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9925:ASIC1
gene id: 9925:ASIC1
uniprot id: A0A452G5G4
names: Subcellular Location Annotation
messages: Membrane

9925:KDR
gene id: 9925:KDR
uniprot id: A0A452DTK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9925:PRPF38A
gene id: 9925:PRPF38A
uniprot id: A0A452FZB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9925:NHSL1
gene id: 9925:NHSL1
uniprot id: A0A452EVY2
uniprot id: A0A452EVY4
uniprot id: A0A452EVZ4
uniprot id: A0A452EW19
uniprot id: A0A452EW29
names: Similarity
messages: Belongs to the NHS family.

9925:WT1
gene id: 9925:WT1
uniprot id: A0A452EEJ8
uniprot id: A0A452EET1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

9925:ATF7IP2
gene id: 9925:ATF7IP2
uniprot id: A0A452DW97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9925:TLX2
gene id: 9925:TLX2
uniprot id: A0A452FZ32
names: Subcellular Location Annotation
messages: Nucleus

9925:CTSB
gene id: 9925:CTSB
uniprot id: H9B8T9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9925:EEF2K
gene id: 9925:EEF2K
uniprot id: A0A452E2Z6
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9925:LOC102184254
gene id: 9925:LOC102184254
uniprot id: A0A452DNZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:VSNL1
gene id: 9925:VSNL1
uniprot id: A0A452DTK2
names: Function
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

9925:ALDH1A3
gene id: 9925:ALDH1A3
uniprot id: A0A452FFP9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:LOC102177535
gene id: 9925:LOC102177535
uniprot id: A0A452EDP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC108637636
gene id: 9925:LOC108637636
uniprot id: A0A452E5Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9925:LACE1
gene id: 9925:LACE1
uniprot id: A0A452ET46
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9925:SEC24D
gene id: 9925:SEC24D
uniprot id: A0A452G372
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9925:ZFHX3
gene id: 9925:ZFHX3
uniprot id: A0A452F5N9
names: Subcellular Location Annotation
messages: Nucleus

9925:SLC12A9
gene id: 9925:SLC12A9
uniprot id: A0A452GA06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9925:SERPINA12
gene id: 9925:SERPINA12
uniprot id: A0A452ETR7
uniprot id: A0A452EU68
names: Similarity
messages: Belongs to the serpin family.

9925:HAPLN1
gene id: 9925:HAPLN1
uniprot id: A0A452FU44
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:BTBD10
gene id: 9925:BTBD10
uniprot id: A0A452G741
uniprot id: A0A452G772
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LVRN
gene id: 9925:LVRN
uniprot id: A0A452G0C4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9925:FAM57A
gene id: 9925:FAM57A
uniprot id: A0A452EUZ8
names: Subcellular Location Annotation
messages: Membrane

9925:ZC3H12D
gene id: 9925:ZC3H12D
uniprot id: A0A452G5G5
names: Similarity
messages: Belongs to the ZC3H12 family.

9925:UNC50
gene id: 9925:UNC50
uniprot id: A0A452EJH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane
messages: Nucleus inner membrane

9925:RIMKLB
gene id: 9925:RIMKLB
uniprot id: A0A452FQN4
names: Similarity
messages: Belongs to the RimK family.

9925:CLIC5
gene id: 9925:CLIC5
uniprot id: A0A452EKX9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9925:SERINC1
gene id: 9925:SERINC1
uniprot id: A0A452EMC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9925:LOC102175959
gene id: 9925:LOC102175959
uniprot id: A0A452FJG4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:DLG1
gene id: 9925:DLG1
uniprot id: A0A452E2S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane

9925:MTOR
gene id: 9925:MTOR
uniprot id: A0A452FCH1
uniprot id: D9I5T4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9925:SNX8
gene id: 9925:SNX8
uniprot id: A0A452FK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9925:LOC102190551
gene id: 9925:LOC102190551
uniprot id: A0A452E3N0
names: Subcellular Location Annotation
messages: nucleoplasm

9925:NAALADL2
gene id: 9925:NAALADL2
uniprot id: A0A452F6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Membrane

9925:REXO4
gene id: 9925:REXO4
uniprot id: A0A452DZR9
names: Similarity
messages: Belongs to the REXO4 family.

9925:PAQR5
gene id: 9925:PAQR5
uniprot id: A0A452EWU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9925:ADCY1
gene id: 9925:ADCY1
uniprot id: A0A452FYH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9925:MAP3K14
gene id: 9925:MAP3K14
uniprot id: A0A452EZ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9925:DLGAP5
gene id: 9925:DLGAP5
uniprot id: A0A452F1S7
names: Similarity
messages: Belongs to the SAPAP family.

9925:LOC102170932
gene id: 9925:LOC102170932
uniprot id: A0A452E0H2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9925:TRPV4
gene id: 9925:TRPV4
uniprot id: A0A452EIF3
names: Subcellular Location Annotation
messages: Membrane

9925:MBD4
gene id: 9925:MBD4
uniprot id: A0A452E131
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MLH1.
messages: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
messages: Nucleus

9925:CLPS
gene id: 9925:CLPS
uniprot id: A0A452F0I6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9925:CD44
gene id: 9925:CD44
uniprot id: A0A452FIS2
uniprot id: A0A452FIT1
uniprot id: A0A452FIY5
uniprot id: A0A452FJ16
uniprot id: A0A452FJA8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

9925:CPB2
gene id: 9925:CPB2
uniprot id: A0A452EX71
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:STEAP4
gene id: 9925:STEAP4
uniprot id: A0A452DXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9925:MCUR1
gene id: 9925:MCUR1
uniprot id: A0A452EE16
names: Similarity
messages: Belongs to the CCDC90 family.

9925:LOC100861174
gene id: 9925:LOC100861174
uniprot id: Q6R647
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:HHIPL2
gene id: 9925:HHIPL2
uniprot id: A0A452EP48
names: Similarity
messages: Belongs to the HHIP family.

9925:SLC7A2
gene id: 9925:SLC7A2
uniprot id: A0A452G3W3
uniprot id: A0A452G426
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9925:GNPTAB
gene id: 9925:GNPTAB
uniprot id: A0A452FWU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

9925:NIPSNAP1
gene id: 9925:NIPSNAP1
uniprot id: A0A452FNU8
names: Similarity
messages: Belongs to the NipSnap family.

9925:STK4
gene id: 9925:STK4
uniprot id: A0A452DPL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9925:ALG3
gene id: 9925:ALG3
uniprot id: A0A452ESW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:PRDX2
gene id: 9925:PRDX2
uniprot id: A0A452DY24
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9925:CCR9
gene id: 9925:CCR9
uniprot id: A0A452EM82
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:GSTM3
gene id: 9925:GSTM3
uniprot id: A0A452E0A7
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9925:ACTN1
gene id: 9925:ACTN1
uniprot id: A0A452ETN5
uniprot id: A0A452ETZ6
names: Similarity
messages: Belongs to the alpha-actinin family.

9925:PMEL
gene id: 9925:PMEL
uniprot id: A0A452G025
names: Similarity
messages: Belongs to the PMEL/NMB family.

9925:ATP6V1H
gene id: 9925:ATP6V1H
uniprot id: A0A452EVE9
uniprot id: A0A452EVG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9925:MTUS1
gene id: 9925:MTUS1
uniprot id: A0A452EVW8
uniprot id: A0A452EVX8
uniprot id: A0A452EVY1
uniprot id: A0A452EW01
uniprot id: A0A452EW04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTUS1 family.
messages: Nucleus

9925:GIPC3
gene id: 9925:GIPC3
uniprot id: A0A452F7A4
names: Similarity
messages: Belongs to the GIPC family.

9925:NR0B2
gene id: 9925:NR0B2
uniprot id: A0A452G9Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9925:QPCT
gene id: 9925:QPCT
uniprot id: A0A452EXV2
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9925:GGA1
gene id: 9925:GGA1
uniprot id: A0A452ELB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9925:NPY2R
gene id: 9925:NPY2R
uniprot id: A0A452E276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:LOC102171899
gene id: 9925:LOC102171899
uniprot id: A0A452FZW5
names: Similarity
messages: Belongs to the MS4A family.

9925:SDC1
gene id: 9925:SDC1
uniprot id: A0A452F6G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane
messages: extracellular exosome

9925:ALDH9A1
gene id: 9925:ALDH9A1
uniprot id: A0A8C2QRR7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:UBE2M
gene id: 9925:UBE2M
uniprot id: A0A452EWN3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:WNT11
gene id: 9925:WNT11
uniprot id: A0A452FJS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:KCNJ1
gene id: 9925:KCNJ1
uniprot id: A0A8C2PAN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9925:ARRB1
gene id: 9925:ARRB1
uniprot id: A0A452EHP7
uniprot id: A0A452EHT6
names: Similarity
messages: Belongs to the arrestin family.

9925:LOC102189300
gene id: 9925:LOC102189300
uniprot id: A0A452DXT4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CASQ2
gene id: 9925:CASQ2
uniprot id: A0A452EKU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9925:ANXA5
gene id: 9925:ANXA5
uniprot id: A0A452FKQ6
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9925:POLR2I
gene id: 9925:POLR2I
uniprot id: A0A452E9U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9925:TTR
gene id: 9925:TTR
uniprot id: A0A452E2C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9925:CNDP2
gene id: 9925:CNDP2
uniprot id: A0A452DJZ6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9925:TSPYL4
gene id: 9925:TSPYL4
uniprot id: A0A8C2R2L8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9925:TSR1
gene id: 9925:TSR1
uniprot id: A0A452FW21
names: Subcellular Location Annotation
messages: nucleolus

9925:NAPRT
gene id: 9925:NAPRT
uniprot id: A0A8C2NN19
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

9925:TNS3
gene id: 9925:TNS3
uniprot id: A0A452GB50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9925:CCHCR1
gene id: 9925:CCHCR1
uniprot id: A0A452FBK3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9925:E2F7
gene id: 9925:E2F7
uniprot id: A0A452FTI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9925:ISOC1
gene id: 9925:ISOC1
uniprot id: A0A452F7M8
names: Similarity
messages: Belongs to the isochorismatase family.

9925:A2ML1
gene id: 9925:A2ML1
uniprot id: A0A452ECU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9925:SLC24A4
gene id: 9925:SLC24A4
uniprot id: A0A452EPH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9925:GGA3
gene id: 9925:GGA3
uniprot id: A0A452DP37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9925:MRPL46
gene id: 9925:MRPL46
uniprot id: A0A452ET13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9925:ELAVL4
gene id: 9925:ELAVL4
uniprot id: A0A452DN64
uniprot id: A0A452DN75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9925:CHRM2
gene id: 9925:CHRM2
uniprot id: A0A452DPN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9925:LOC102174408
gene id: 9925:LOC102174408
uniprot id: A0A452DNM7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:JUP
gene id: 9925:JUP
uniprot id: A0A452G6Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
messages: Membrane
messages: adherens junction
messages: desmosome

9925:ZSCAN31
gene id: 9925:ZSCAN31
uniprot id: A0A452ED52
names: Subcellular Location Annotation
messages: Nucleus

9925:FAM198B
gene id: 9925:FAM198B
uniprot id: A0A452G4R9
names: Similarity
messages: Belongs to the GASK family.

9925:LOC108636012
gene id: 9925:LOC108636012
uniprot id: A0A452DUP8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC102187154
gene id: 9925:LOC102187154
uniprot id: A0A452G6M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9925:VPS45
gene id: 9925:VPS45
uniprot id: A0A452E4J0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9925:LOC102183988
gene id: 9925:LOC102183988
uniprot id: A0A452DQT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:VTI1A
gene id: 9925:VTI1A
uniprot id: A0A452E9P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9925:INIP
gene id: 9925:INIP
uniprot id: A0A8C2PKD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9925:PPP6R3
gene id: 9925:PPP6R3
uniprot id: A0A452FDQ2
names: Similarity
messages: Belongs to the SAPS family.

9925:TMED10
gene id: 9925:TMED10
uniprot id: A0A452FNM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LOC100861381
gene id: 9925:LOC100861381
uniprot id: Q6R651
names: Similarity
messages: Belongs to the intermediate filament family.

9925:HCN4
gene id: 9925:HCN4
uniprot id: A0A452E8B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9925:ATP9A
gene id: 9925:ATP9A
uniprot id: A0A452F1N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9925:STMN4
gene id: 9925:STMN4
uniprot id: A0A452FDU8
uniprot id: A0A452FE73
uniprot id: A0A8C2XZP1
names: Similarity
messages: Belongs to the stathmin family.

9925:SEMA3B
gene id: 9925:SEMA3B
uniprot id: A0A8C2Y406
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ADCY8
gene id: 9925:ADCY8
uniprot id: A0A452G620
uniprot id: A0A452G653
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9925:RHBDL3
gene id: 9925:RHBDL3
uniprot id: A0A452G349
uniprot id: A0A452G355
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9925:LOC102181570
gene id: 9925:LOC102181570
uniprot id: A0A452DV78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102176008
gene id: 9925:LOC102176008
uniprot id: A0A452DUC4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9925:ANAPC13
gene id: 9925:ANAPC13
uniprot id: A0A452FEA1
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9925:CTTNBP2
gene id: 9925:CTTNBP2
uniprot id: A0A452EPC3
uniprot id: A0A452EPR6
names: Subcellular Location Annotation
messages: cell cortex
messages: dendritic spine

9925:SSR2
gene id: 9925:SSR2
uniprot id: A0A452GB04
uniprot id: A0A8C2NGG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9925:MRPS18A
gene id: 9925:MRPS18A
uniprot id: A0A452EEG4
uniprot id: A0A8C2RU57
names: Subcellular Location Annotation
messages: Mitochondrion

9925:EMX1
gene id: 9925:EMX1
uniprot id: A0A452E9L5
names: Subcellular Location Annotation
messages: Nucleus

9925:FAM46C
gene id: 9925:FAM46C
uniprot id: A0A452DRJ3
names: Similarity
messages: Belongs to the TENT family.

9925:CCDC85A
gene id: 9925:CCDC85A
uniprot id: A0A452EX46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9925:COQ5
gene id: 9925:COQ5
uniprot id: A0A452F991
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9925:GSKIP
gene id: 9925:GSKIP
uniprot id: A0A452EEJ4
names: Similarity
messages: Belongs to the GSKIP family.

9925:LOC108638300
gene id: 9925:LOC108638300
uniprot id: A0A452DUN1
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:TMEM150C
gene id: 9925:TMEM150C
uniprot id: A0A452ECM4
names: Subcellular Location Annotation
messages: Membrane

9925:GPR61
gene id: 9925:GPR61
uniprot id: A0A452DM10
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:PTGES
gene id: 9925:PTGES
uniprot id: A0A452FZ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9925:TRMO
gene id: 9925:TRMO
uniprot id: A0A452E237
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9925:LOC102169753
gene id: 9925:LOC102169753
uniprot id: A0A452ECT8
names: Similarity
messages: Belongs to the MHC class I family.

9925:LOC102181164
gene id: 9925:LOC102181164
uniprot id: A0A452E0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9925:LOC108636029
gene id: 9925:LOC108636029
uniprot id: A0A452DUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9925:PPP2R5C
gene id: 9925:PPP2R5C
uniprot id: A0A452FL21
uniprot id: A0A452FL26
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9925:LAMTOR3
gene id: 9925:LAMTOR3
uniprot id: A0A1B2VWD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9925:CELF2
gene id: 9925:CELF2
uniprot id: A0A452EQG8
uniprot id: A0A452EQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9925:LOC102188618
gene id: 9925:LOC102188618
uniprot id: A0A452FF89
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9925:DLST
gene id: 9925:DLST
uniprot id: A0A452ERW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9925:EPG5
gene id: 9925:EPG5
uniprot id: A0A452DQ00
names: Similarity
messages: Belongs to the EPG5 family.

9925:FGF20
gene id: 9925:FGF20
uniprot id: A0A452EP49
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:STX17
gene id: 9925:STX17
uniprot id: A0A452ENT2
names: Similarity
messages: Belongs to the syntaxin family.

9925:EXOC1
gene id: 9925:EXOC1
uniprot id: A0A452FKX4
uniprot id: A0A452FL20
uniprot id: A0A452FM83
names: Similarity
messages: Belongs to the SEC3 family.

9925:TLE2
gene id: 9925:TLE2
uniprot id: A0A452GA71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9925:XRN2
gene id: 9925:XRN2
uniprot id: A0A452DTJ8
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9925:CDH20
gene id: 9925:CDH20
uniprot id: A0A452G978
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:ABCB11
gene id: 9925:ABCB11
uniprot id: A0A452FGQ7
uniprot id: A0A452FHA9
names: Subcellular Location Annotation
messages: Endosome

9925:ATAD2B
gene id: 9925:ATAD2B
uniprot id: A0A452EWS0
names: Similarity
messages: Belongs to the AAA ATPase family.

9925:NDRG4
gene id: 9925:NDRG4
uniprot id: A0A452FJX5
uniprot id: A0A452FKQ2
uniprot id: A0A8C2SEP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: cytosol

9925:DUPD1
gene id: 9925:DUPD1
uniprot id: A0A8C2S282
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9925:SF1
gene id: 9925:SF1
uniprot id: A0A452G4Y3
uniprot id: A0A452G505
uniprot id: A0A8C2R2C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

9925:GRK6
gene id: 9925:GRK6
uniprot id: A0A452FBD0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9925:DVL1
gene id: 9925:DVL1
uniprot id: A0A452ENR1
names: Similarity
messages: Belongs to the DSH family.

9925:TMEM120B
gene id: 9925:TMEM120B
uniprot id: A0A452EMM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9925:ACAA1
gene id: 9925:ACAA1
uniprot id: A0A452E401
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9925:LOC102172172
gene id: 9925:LOC102172172
uniprot id: A0A452E3Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MEF2D
gene id: 9925:MEF2D
uniprot id: A0A452E3I6
uniprot id: U5HTF1
names: Subcellular Location Annotation
messages: Nucleus

9925:GJB4
gene id: 9925:GJB4
uniprot id: A0A452E199
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:KATNA1
gene id: 9925:KATNA1
uniprot id: A0A452F210
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

9925:DOC2A
gene id: 9925:DOC2A
uniprot id: A0A452EEX7
names: Subcellular Location Annotation
messages: Membrane

9925:CDC42EP5
gene id: 9925:CDC42EP5
uniprot id: A0A452E738
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9925:CDCA2
gene id: 9925:CDCA2
uniprot id: A0A452F5M1
names: Subcellular Location Annotation
messages: Nucleus

9925:LSM1
gene id: 9925:LSM1
uniprot id: A0A452EFL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9925:RAF1
gene id: 9925:RAF1
uniprot id: A0A452DTI5
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9925:MYLK2
gene id: 9925:MYLK2
uniprot id: A0A452EYU2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May interact with centrin.

9925:LOC102175539
gene id: 9925:LOC102175539
uniprot id: A0A452E9N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TNFAIP6
gene id: 9925:TNFAIP6
uniprot id: A0A452EFF9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:IL20
gene id: 9925:IL20
uniprot id: A0A452ECT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9925:C1QA
gene id: 9925:C1QA
uniprot id: A0A452FZ76
names: Function
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

9925:CLDN1
gene id: 9925:CLDN1
uniprot id: A0A452FI51
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:NUDC
gene id: 9925:NUDC
uniprot id: A0A452E1B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9925:LOC102185617
gene id: 9925:LOC102185617
uniprot id: A0A452E490
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9925:SLC16A7
gene id: 9925:SLC16A7
uniprot id: A0A452ERQ5
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

9925:LRRC8B
gene id: 9925:LRRC8B
uniprot id: A0A452G5Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9925:STT3A
gene id: 9925:STT3A
uniprot id: A0A452FZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9925:CSN1S1
gene id: 9925:CSN1S1
uniprot id: A0A858NCR7
uniprot id: P18626
uniprot id: Q69EZ6
uniprot id: Q8MIH4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted
messages: The sequence shown is variant form B.

9925:GOLPH3L
gene id: 9925:GOLPH3L
uniprot id: A0A452F2Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9925:BORCS5
gene id: 9925:BORCS5
uniprot id: A0A452EXG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9925:LOC102170509
gene id: 9925:LOC102170509
uniprot id: A0A452DU60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PPM1K
gene id: 9925:PPM1K
uniprot id: A0A452ESG0
names: Similarity
messages: Belongs to the PP2C family.

9925:EEF2KMT
gene id: 9925:EEF2KMT
uniprot id: A0A452EPV4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

9925:CNKSR3
gene id: 9925:CNKSR3
uniprot id: A0A452DPC7
names: Similarity
messages: Belongs to the CNKSR family.

9925:L3MBTL2
gene id: 9925:L3MBTL2
uniprot id: A0A452FIT6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9925:PURA
gene id: 9925:PURA
uniprot id: A0A452DZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9925:SNX5
gene id: 9925:SNX5
uniprot id: A0A452F344
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9925:XPOT
gene id: 9925:XPOT
uniprot id: A0A452F514
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9925:RSPO1
gene id: 9925:RSPO1
uniprot id: A4UTK5
names: Similarity
messages: Belongs to the R-spondin family.

9925:FAM47E
gene id: 9925:FAM47E
uniprot id: A0A452G1V6
names: Similarity
messages: Belongs to the FAM47 family.

9925:ARAP3
gene id: 9925:ARAP3
uniprot id: A0A452E0G6
names: Subcellular Location Annotation
messages: Cytoplasm

9925:TCF7L1
gene id: 9925:TCF7L1
uniprot id: A0A452E532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9925:LOC102183528
gene id: 9925:LOC102183528
uniprot id: A0A452DYI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MCCC2
gene id: 9925:MCCC2
uniprot id: A0A452FSB8
names: Similarity
messages: Belongs to the AccD/PCCB family.

9925:INTS12
gene id: 9925:INTS12
uniprot id: A0A452FLH2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9925:IFNA
gene id: 9925:IFNA
uniprot id: C5IU72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:NDC80
gene id: 9925:NDC80
uniprot id: A0A452DL00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9925:LOC102180061
gene id: 9925:LOC102180061
uniprot id: A0A452DQE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DLX3
gene id: 9925:DLX3
uniprot id: A0A452E4Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9925:ANKRD34B
gene id: 9925:ANKRD34B
uniprot id: A0A452E1F7
names: Similarity
messages: Belongs to the ANKRD34 family.

9925:AP5M1
gene id: 9925:AP5M1
uniprot id: A0A452EZ59
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9925:TNN
gene id: 9925:TNN
uniprot id: A0A452EVN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9925:SOX21
gene id: 9925:SOX21
uniprot id: A0A452FAF2
names: Subcellular Location Annotation
messages: Nucleus

9925:GFRA1
gene id: 9925:GFRA1
uniprot id: A0A452EPG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9925:LGI2
gene id: 9925:LGI2
uniprot id: A0A452FMI4
names: Subcellular Location Annotation
messages: Secreted

9925:P2RX7
gene id: 9925:P2RX7
uniprot id: A0A452FP31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9925:MMP9
gene id: 9925:MMP9
uniprot id: A0A059PAA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M10A family.
messages: Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with LCN2. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.
messages: extracellular matrix

9925:PSMD3
gene id: 9925:PSMD3
uniprot id: A0A452DQ07
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9925:UTP3
gene id: 9925:UTP3
uniprot id: A0A452DN76
names: Similarity
messages: Belongs to the SAS10 family.

9925:CCT8
gene id: 9925:CCT8
uniprot id: A0A452F2M2
uniprot id: A0A452F2N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

9925:SUPT20H
gene id: 9925:SUPT20H
uniprot id: A0A452E4P5
names: Similarity
messages: Belongs to the SPT20 family.

9925:PARP14
gene id: 9925:PARP14
uniprot id: A0A452F597
names: Similarity
messages: Belongs to the ARTD/PARP family.

9925:PLAT
gene id: 9925:PLAT
uniprot id: A0A452DK58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:TPRG1L
gene id: 9925:TPRG1L
uniprot id: A0A452DU01
names: Similarity
messages: Belongs to the TPRG1 family.

9925:METAP1
gene id: 9925:METAP1
uniprot id: A0A452FLJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9925:C1H21orf59
gene id: 9925:C1H21orf59
uniprot id: A0A452G9S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9925:OVOL2
gene id: 9925:OVOL2
uniprot id: A0A452F9V3
names: Subcellular Location Annotation
messages: Nucleus

9925:RPL29
gene id: 9925:RPL29
uniprot id: A0A452EI45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9925:E2F3
gene id: 9925:E2F3
uniprot id: A0A452E4U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9925:GJC1
gene id: 9925:GJC1
uniprot id: A0A452DY69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:SERPINE2
gene id: 9925:SERPINE2
uniprot id: A0A452EUU7
names: Similarity
messages: Belongs to the serpin family.

9925:NT5DC2
gene id: 9925:NT5DC2
uniprot id: A0A452FVJ3
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9925:ASPDH
gene id: 9925:ASPDH
uniprot id: A0A452FQL2
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9925:TMEM86B
gene id: 9925:TMEM86B
uniprot id: A0A8C2XWK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9925:PARL
gene id: 9925:PARL
uniprot id: A0A452G6F0
names: Subcellular Location Annotation
messages: Membrane

9925:SCD5
gene id: 9925:SCD5
uniprot id: A0A452F3E5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9925:AKT1
gene id: 9925:AKT1
uniprot id: A0A249RNJ6
uniprot id: D9IA52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
messages: Cytoplasm

9925:SRSF4
gene id: 9925:SRSF4
uniprot id: A0A452FLL1
names: Similarity
messages: Belongs to the splicing factor SR family.

9925:RITA1
gene id: 9925:RITA1
uniprot id: A0A452E5Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RITA family.
messages: Cytoplasm
messages: Interacts with RBPJ/RBPSUH.
messages: Nucleus
messages: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

9925:PMVK
gene id: 9925:PMVK
uniprot id: A0A452FYM9
names: Subcellular Location Annotation
messages: cytosol

9925:SLC34A1
gene id: 9925:SLC34A1
uniprot id: A0A452F936
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9925:LOC102181022
gene id: 9925:LOC102181022
uniprot id: A0A452DQR2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:S1PR5
gene id: 9925:S1PR5
uniprot id: A0A452EFL9
names: Subcellular Location Annotation
messages: Membrane

9925:RPL22
gene id: 9925:RPL22
uniprot id: A0A452FZD1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9925:KRT7
gene id: 9925:KRT7
uniprot id: A0A452FER9
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LOC102191000
gene id: 9925:LOC102191000
uniprot id: A0A452ESX4
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:MAB21L3
gene id: 9925:MAB21L3
uniprot id: A0A452F7C4
names: Similarity
messages: Belongs to the mab-21 family.

9925:GALNT18
gene id: 9925:GALNT18
uniprot id: A0A452EAU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:GOLM1
gene id: 9925:GOLM1
uniprot id: A0A452FQ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9925:CDK2AP2
gene id: 9925:CDK2AP2
uniprot id: A0A452FGI9
names: Similarity
messages: Belongs to the CDK2AP family.

9925:RIOK2
gene id: 9925:RIOK2
uniprot id: A0A452EWW4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9925:BVES
gene id: 9925:BVES
uniprot id: A0A452DWR8
names: Similarity
messages: Belongs to the popeye family.

9925:SMOC2
gene id: 9925:SMOC2
uniprot id: A0A452FZM6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:KIAA2013
gene id: 9925:KIAA2013
uniprot id: A0A452G8F0
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102190122
gene id: 9925:LOC102190122
uniprot id: A0A452DWS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC108638107
gene id: 9925:LOC108638107
uniprot id: A0A452EVC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9925:LOC102184151
gene id: 9925:LOC102184151
uniprot id: A0A452DTE2
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9925:LOC102170564
gene id: 9925:LOC102170564
uniprot id: A0A452FFP7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9925:DDIT4
gene id: 9925:DDIT4
uniprot id: A0A452E9D5
names: Similarity
messages: Belongs to the DDIT4 family.

9925:LOC100861164
gene id: 9925:LOC100861164
uniprot id: Q6UZ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:LOC102178870
gene id: 9925:LOC102178870
uniprot id: A0A452DW09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:SYPL2
gene id: 9925:SYPL2
uniprot id: A0A452E641
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9925:CSTA
gene id: 9925:CSTA
uniprot id: A0A452EZ91
names: Similarity
messages: Belongs to the cystatin family.

9925:TNS1
gene id: 9925:TNS1
uniprot id: A0A452ELZ4
uniprot id: A0A452EMM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9925:HRH2
gene id: 9925:HRH2
uniprot id: A0A452FM69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:GPR182
gene id: 9925:GPR182
uniprot id: A0A452DW22
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:COG3
gene id: 9925:COG3
uniprot id: A0A452FJ96
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9925:PPTC7
gene id: 9925:PPTC7
uniprot id: A0A452FCJ3
names: Similarity
messages: Belongs to the PP2C family.

9925:VIPR2
gene id: 9925:VIPR2
uniprot id: A0A452G0E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9925:RXFP4
gene id: 9925:RXFP4
uniprot id: A0A452EDT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:AGPAT4
gene id: 9925:AGPAT4
uniprot id: A0A452EWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9925:LOC102177414
gene id: 9925:LOC102177414
uniprot id: A0A452E3P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9925:CMKLR1
gene id: 9925:CMKLR1
uniprot id: A0A452E3R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9925:IZUMO4
gene id: 9925:IZUMO4
uniprot id: A0A8C2SFC6
names: Similarity
messages: Belongs to the Izumo family.

9925:LOC102181052
gene id: 9925:LOC102181052
uniprot id: A0A452FWM8
uniprot id: A0A452FXE2
names: Similarity
messages: Belongs to the SELO family.

9925:ONECUT2
gene id: 9925:ONECUT2
uniprot id: A0A452EAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9925:CSF3R
gene id: 9925:CSF3R
uniprot id: A0A452DT24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9925:MPDU1
gene id: 9925:MPDU1
uniprot id: A0A452F8I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9925:MED24
gene id: 9925:MED24
uniprot id: A0A452FBA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9925:QRSL1
gene id: 9925:QRSL1
uniprot id: A0A452F041
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9925:MRPL15
gene id: 9925:MRPL15
uniprot id: A0A452DM81
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9925:NID2
gene id: 9925:NID2
uniprot id: A0A452F5Y3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9925:FADD
gene id: 9925:FADD
uniprot id: A0A452DW12
names: Function
messages: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

9925:LOC102174664
gene id: 9925:LOC102174664
uniprot id: A0A452EH73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9925:LOC102179500
gene id: 9925:LOC102179500
uniprot id: A0A452EE28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102180330
gene id: 9925:LOC102180330
uniprot id: A0A452F0P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9925:PFN2
gene id: 9925:PFN2
uniprot id: A0A452FL85
names: Function
names: Similarity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

9925:LOC100861136
gene id: 9925:LOC100861136
uniprot id: A0A452E2N1
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9925:ATG2A
gene id: 9925:ATG2A
uniprot id: A0A452EY85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9925:CDK5R2
gene id: 9925:CDK5R2
uniprot id: A0A452EDF0
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

9925:SUGP2
gene id: 9925:SUGP2
uniprot id: A0A452DM17
names: Subcellular Location Annotation
messages: Nucleus

9925:EPC2
gene id: 9925:EPC2
uniprot id: A0A452FXZ9
uniprot id: A0A452FY97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9925:CD180
gene id: 9925:CD180
uniprot id: A0A452EAZ3
names: Similarity
messages: Belongs to the Toll-like receptor family.

9925:LOC102177153
gene id: 9925:LOC102177153
uniprot id: A0A452FXC1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9925:CHFR
gene id: 9925:CHFR
uniprot id: A0A8C2RLP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHFR family.
messages: PML body

9925:RTN3
gene id: 9925:RTN3
uniprot id: A0A452EJX2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:SPARCL1
gene id: 9925:SPARCL1
uniprot id: A0A452DTT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9925:ETFA
gene id: 9925:ETFA
uniprot id: A0A452ER52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9925:RNF10
gene id: 9925:RNF10
uniprot id: A0A452G5K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

9925:PTH
gene id: 9925:PTH
uniprot id: A0A452DUJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
messages: Secreted

9925:SLC35F6
gene id: 9925:SLC35F6
uniprot id: A0A452FI78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9925:SLC25A11
gene id: 9925:SLC25A11
uniprot id: A0A452FB58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:LOC102172041
gene id: 9925:LOC102172041
uniprot id: A0A452E350
names: Similarity
messages: Belongs to the apolipoprotein L family.

9925:GCNT7
gene id: 9925:GCNT7
uniprot id: A0A452E9J2
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9925:PLRG1
gene id: 9925:PLRG1
uniprot id: A0A452EJH1
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9925:ITGA2
gene id: 9925:ITGA2
uniprot id: A0A452G912
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:NSUN3
gene id: 9925:NSUN3
uniprot id: A0A452ED26
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9925:AK3
gene id: 9925:AK3
uniprot id: A0A452FYF6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9925:RPS18
gene id: 9925:RPS18
uniprot id: A5JST6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Cytoplasm
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

9925:TMEM63A
gene id: 9925:TMEM63A
uniprot id: A0A665AV17
uniprot id: W6AWL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9925:CPA6
gene id: 9925:CPA6
uniprot id: A0A452FS08
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:NDUFB5
gene id: 9925:NDUFB5
uniprot id: A0A452G0J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:TBCCD1
gene id: 9925:TBCCD1
uniprot id: A0A452DQE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9925:SLC16A9
gene id: 9925:SLC16A9
uniprot id: A0A452G4W5
names: Subcellular Location Annotation
messages: Membrane

9925:FAM171B
gene id: 9925:FAM171B
uniprot id: A0A452E6A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9925:FN3KRP
gene id: 9925:FN3KRP
uniprot id: A0A452FYD7
names: Similarity
messages: Belongs to the fructosamine kinase family.

9925:CPVL
gene id: 9925:CPVL
uniprot id: A0A452ETC0
names: Similarity
messages: Belongs to the peptidase S10 family.

9925:LOC102172949
gene id: 9925:LOC102172949
uniprot id: A0A452EB46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

9925:HNRNPAB
gene id: 9925:HNRNPAB
uniprot id: A0A452FJU7
uniprot id: A0A452FKD5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:ALDH8A1
gene id: 9925:ALDH8A1
uniprot id: A0A452FSX2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:USP16
gene id: 9925:USP16
uniprot id: A0A452G3Y9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9925:POLD2
gene id: 9925:POLD2
uniprot id: A0A452E0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9925:GSX1
gene id: 9925:GSX1
uniprot id: A0A452G5U0
names: Subcellular Location Annotation
messages: Nucleus

9925:TPRG1
gene id: 9925:TPRG1
uniprot id: A0A452DQY4
names: Similarity
messages: Belongs to the TPRG1 family.

9925:KIFC3
gene id: 9925:KIFC3
uniprot id: A0A452FWX8
uniprot id: A0A452FX82
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:LOC102174112
gene id: 9925:LOC102174112
uniprot id: A0A452DSH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NCAPG
gene id: 9925:NCAPG
uniprot id: A0A452ECB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9925:CCNB1
gene id: 9925:CCNB1
uniprot id: A0A452EUV5
names: Similarity
messages: Belongs to the cyclin family.

9925:SYCP2L
gene id: 9925:SYCP2L
uniprot id: A0A452F4U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYCP2 family.
messages: Nucleus

9925:FSHR
gene id: 9925:FSHR
uniprot id: B5AFX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation.
messages: Membrane

9925:LOC102183766
gene id: 9925:LOC102183766
uniprot id: A0A452F6N1
names: Similarity
messages: Belongs to the intermediate filament family.

9925:GTF2B
gene id: 9925:GTF2B
uniprot id: A0A452G5K0
names: Similarity
messages: Belongs to the TFIIB family.

9925:HOXA11
gene id: 9925:HOXA11
uniprot id: A0A452FEU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:LOC102179993
gene id: 9925:LOC102179993
uniprot id: A0A452DNZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9925:LOC102175265
gene id: 9925:LOC102175265
uniprot id: A0A452EX00
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:C19H17orf62
gene id: 9925:C19H17orf62
uniprot id: A0A452DRJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:ISYNA1
gene id: 9925:ISYNA1
uniprot id: A0A452FRH9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

9925:FAM129A
gene id: 9925:FAM129A
uniprot id: A0A452EQ52
names: Similarity
messages: Belongs to the Niban family.

9925:IRF5
gene id: 9925:IRF5
uniprot id: A0A8C2PII9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:GDAP1
gene id: 9925:GDAP1
uniprot id: A0A452DT50
names: Similarity
messages: Belongs to the GST superfamily.

9925:DGKE
gene id: 9925:DGKE
uniprot id: A0A452FWK5
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9925:LCAT
gene id: 9925:LCAT
uniprot id: A0A452EJ90
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9925:PRDM8
gene id: 9925:PRDM8
uniprot id: A0A452F8M9
names: Subcellular Location Annotation
messages: Nucleus

9925:ATF4
gene id: 9925:ATF4
uniprot id: A0A452EN02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9925:FAM65C
gene id: 9925:FAM65C
uniprot id: A0A452FKU6
names: Similarity
messages: Belongs to the RIPOR family.

9925:LOC102171143
gene id: 9925:LOC102171143
uniprot id: A0A452EYL2
names: Similarity
messages: Belongs to the apolipoprotein L family.

9925:SRMS
gene id: 9925:SRMS
uniprot id: A0A452EJS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:INPP5B
gene id: 9925:INPP5B
uniprot id: A0A452E8A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

9925:SENP7
gene id: 9925:SENP7
uniprot id: A0A452DV21
names: Similarity
messages: Belongs to the peptidase C48 family.

9925:MTF2
gene id: 9925:MTF2
uniprot id: A0A452FX85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9925:INPP4A
gene id: 9925:INPP4A
uniprot id: A0A452FXH8
uniprot id: A0A452FXJ2
uniprot id: A0A452FXV1
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9925:ROMO1
gene id: 9925:ROMO1
uniprot id: A0A452E3J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9925:SLC25A19
gene id: 9925:SLC25A19
uniprot id: A0A452DQF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:CDKN1B
gene id: 9925:CDKN1B
uniprot id: A0A452EU35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

9925:SLC44A2
gene id: 9925:SLC44A2
uniprot id: A0A452DSN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9925:GALNT8
gene id: 9925:GALNT8
uniprot id: A0A452ENQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:EMC10
gene id: 9925:EMC10
uniprot id: A0A452ESI0
uniprot id: A0A8C2Y4G0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC10 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9925:TLE4
gene id: 9925:TLE4
uniprot id: A0A452FAF4
uniprot id: A0A452FAS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9925:OTP
gene id: 9925:OTP
uniprot id: A0A452F7B5
names: Subcellular Location Annotation
messages: Nucleus

9925:ACTN3
gene id: 9925:ACTN3
uniprot id: A0A452EI96
names: Similarity
messages: Belongs to the alpha-actinin family.

9925:LOC102170120
gene id: 9925:LOC102170120
uniprot id: A0A452G6J2
uniprot id: A0A452G6R2
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:GTF2A1
gene id: 9925:GTF2A1
uniprot id: A0A452ECB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9925:DPF3
gene id: 9925:DPF3
uniprot id: A0A452FYA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the requiem/DPF family.
messages: Nucleus

9925:MTHFD1L
gene id: 9925:MTHFD1L
uniprot id: A0A452G6W1
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9925:PPP6C
gene id: 9925:PPP6C
uniprot id: A0A452DNG0
names: Similarity
messages: Belongs to the PPP phosphatase family.

9925:HBM
gene id: 9925:HBM
uniprot id: A0A8C2R3G3
names: Similarity
messages: Belongs to the globin family.

9925:NDUFA11
gene id: 9925:NDUFA11
uniprot id: A0A452FHJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:NDUFAF7
gene id: 9925:NDUFAF7
uniprot id: A0A452FZV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9925:CCL21
gene id: 9925:CCL21
uniprot id: A0A452G452
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:LOC108634038
gene id: 9925:LOC108634038
uniprot id: A0A452FBC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NETO1
gene id: 9925:NETO1
uniprot id: A0A452EIL4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102185247
gene id: 9925:LOC102185247
uniprot id: A0A452E5U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ADRA1D
gene id: 9925:ADRA1D
uniprot id: A0A452DLY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9925:CDKAL1
gene id: 9925:CDKAL1
uniprot id: A0A452FPK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9925:RAB33B
gene id: 9925:RAB33B
uniprot id: A0A452FDJ3
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9925:KCNQ2
gene id: 9925:KCNQ2
uniprot id: A0A452E7F3
uniprot id: A0A452E7G9
uniprot id: A0A452E7H4
uniprot id: A0A452E7I2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:CHUK
gene id: 9925:CHUK
uniprot id: A0A452EYD5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:LOC102181385
gene id: 9925:LOC102181385
uniprot id: A0A452E1C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TMED7
gene id: 9925:TMED7
uniprot id: A0A452EK79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9925:PRRX2
gene id: 9925:PRRX2
uniprot id: A0A452FYV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9925:CACHD1
gene id: 9925:CACHD1
uniprot id: A0A452ECE3
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9925:LOC108638299
gene id: 9925:LOC108638299
uniprot id: A0A452DY08
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:LOC102181069
gene id: 9925:LOC102181069
uniprot id: A0A452EF45
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:BLOC1S5
gene id: 9925:BLOC1S5
uniprot id: A0A452EX48
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

9925:PPM1N
gene id: 9925:PPM1N
uniprot id: A0A8C2RX97
names: Similarity
messages: Belongs to the PP2C family.

9925:SMAD2
gene id: 9925:SMAD2
uniprot id: A0A452FCX6
uniprot id: A0A452FCY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9925:POU4F2
gene id: 9925:POU4F2
uniprot id: A0A452EC03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9925:NME6
gene id: 9925:NME6
uniprot id: A0A452G753
names: Similarity
messages: Belongs to the NDK family.

9925:HAGHL
gene id: 9925:HAGHL
uniprot id: A0A452EGI0
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9925:DRD3
gene id: 9925:DRD3
uniprot id: A0A452FTE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9925:ZDHHC7
gene id: 9925:ZDHHC7
uniprot id: A0A452DZE6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:LOC102175203
gene id: 9925:LOC102175203
uniprot id: A0A452DMS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:KCNA5
gene id: 9925:KCNA5
uniprot id: A0A452DMX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

9925:DPY19L4
gene id: 9925:DPY19L4
uniprot id: A0A8C2RY64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9925:TLR5
gene id: 9925:TLR5
uniprot id: C0L636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9925:NAAA
gene id: 9925:NAAA
uniprot id: A0A452ETD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9925:KATNB1
gene id: 9925:KATNB1
uniprot id: A0A452G8E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9925:RFX1
gene id: 9925:RFX1
uniprot id: A0A452G3J4
names: Subcellular Location Annotation
messages: Nucleus

9925:GNA12
gene id: 9925:GNA12
uniprot id: A0A452FX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9925:CENPQ
gene id: 9925:CENPQ
uniprot id: A0A452FJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9925:PFKFB3
gene id: 9925:PFKFB3
uniprot id: A0A452FTG2
uniprot id: A0A452FTI6
uniprot id: A0A452FTP2
uniprot id: A0A8C2R0E2
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9925:CHD7
gene id: 9925:CHD7
uniprot id: A0A452E916
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9925:GIF
gene id: 9925:GIF
uniprot id: A0A452EXR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9925:MED13
gene id: 9925:MED13
uniprot id: A0A452FPL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:LOC102191173
gene id: 9925:LOC102191173
uniprot id: A0A452GAI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:RCAN3
gene id: 9925:RCAN3
uniprot id: A0A452FKG8
names: Similarity
messages: Belongs to the RCAN family.

9925:EIF3A
gene id: 9925:EIF3A
uniprot id: A0A452EWF9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with EIF4G1. Also interacts with KRT7 and PIWIL2.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

9925:AVPR1B
gene id: 9925:AVPR1B
uniprot id: A0A452EUV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9925:POU2F3
gene id: 9925:POU2F3
uniprot id: A0A452EZP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

9925:ENPP6
gene id: 9925:ENPP6
uniprot id: A0A452DPG8
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

9925:UCKL1
gene id: 9925:UCKL1
uniprot id: A0A8C2NUZ2
names: Similarity
messages: Belongs to the uridine kinase family.

9925:LIPG
gene id: 9925:LIPG
uniprot id: A0A8C2R1P4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:PPP4R3B
gene id: 9925:PPP4R3B
uniprot id: A0A452E2N7
names: Similarity
messages: Belongs to the SMEK family.

9925:PARN
gene id: 9925:PARN
uniprot id: A0A452F3G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm
messages: Nucleus

9925:HEXDC
gene id: 9925:HEXDC
uniprot id: A0A452F8Z5
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

9925:LOC102185941
gene id: 9925:LOC102185941
uniprot id: A0A452DZV4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:VEGFA
gene id: 9925:VEGFA
uniprot id: A0A024DAZ8
uniprot id: K4P986
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9925:ARF1
gene id: 9925:ARF1
uniprot id: A0A452E633
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:MYO9B
gene id: 9925:MYO9B
uniprot id: A0A452E9N9
uniprot id: A0A452E9P1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:LOC102181202
gene id: 9925:LOC102181202
uniprot id: A0A452F9S7
names: Similarity
messages: Belongs to the MHC class I family.

9925:KCNS2
gene id: 9925:KCNS2
uniprot id: A0A452DQQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:YAE1D1
gene id: 9925:YAE1D1
uniprot id: A0A452ESZ4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:ZRANB1
gene id: 9925:ZRANB1
uniprot id: A0A452FRP9
names: Similarity
messages: Belongs to the peptidase C64 family.

9925:DSE
gene id: 9925:DSE
uniprot id: A0A452E2D4
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9925:CHRD
gene id: 9925:CHRD
uniprot id: A0A452E873
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
messages: Secreted

9925:AP1G1
gene id: 9925:AP1G1
uniprot id: A0A452DTT2
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9925:PROK2
gene id: 9925:PROK2
uniprot id: A0A1S6PXH4
uniprot id: A0A452FGH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9925:GSR
gene id: 9925:GSR
uniprot id: A0A452EXH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

9925:B3GNT6
gene id: 9925:B3GNT6
uniprot id: A0A452DPB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:IL36B
gene id: 9925:IL36B
uniprot id: A0A452E5N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9925:FTMT
gene id: 9925:FTMT
uniprot id: A0A452DQM4
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9925:VGLL2
gene id: 9925:VGLL2
uniprot id: A0A452EKY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9925:KHSRP
gene id: 9925:KHSRP
uniprot id: A0A452GA60
uniprot id: A0A452GAP9
names: Subcellular Location Annotation
messages: Nucleus

9925:MBTD1
gene id: 9925:MBTD1
uniprot id: A0A452G589
names: Subcellular Location Annotation
messages: Nucleus

9925:PLIN5
gene id: 9925:PLIN5
uniprot id: A0A452FDP3
names: Similarity
messages: Belongs to the perilipin family.

9925:PTEN
gene id: 9925:PTEN
uniprot id: A0A4Y5S4A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

9925:DHCR7
gene id: 9925:DHCR7
uniprot id: A0A452EN35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9925:PLOD1
gene id: 9925:PLOD1
uniprot id: A0A8C2XYH0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9925:PPT1
gene id: 9925:PPT1
uniprot id: A0A452G0W3
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9925:BNIP3L
gene id: 9925:BNIP3L
uniprot id: A0A452FZP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9925:RGS7BP
gene id: 9925:RGS7BP
uniprot id: A0A452DVC1
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9925:ATP6V0A1
gene id: 9925:ATP6V0A1
uniprot id: A0A452FVJ0
uniprot id: A0A452FW46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9925:SUPT16H
gene id: 9925:SUPT16H
uniprot id: A0A452E9E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9925:DEFB121
gene id: 9925:DEFB121
uniprot id: A0A059U1E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9925:UBP1
gene id: 9925:UBP1
uniprot id: A0A452FKK4
uniprot id: A0A452FKT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9925:CCNE2
gene id: 9925:CCNE2
uniprot id: A0A452FPZ6
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9925:LOC102172278
gene id: 9925:LOC102172278
uniprot id: A0A8C2SCK7
names: Similarity
messages: Belongs to the CBP3 family.

9925:PIAS3
gene id: 9925:PIAS3
uniprot id: A0A452E2E1
names: Similarity
messages: Belongs to the PIAS family.

9925:LOC102182181
gene id: 9925:LOC102182181
uniprot id: A0A452E1V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC102173719
gene id: 9925:LOC102173719
uniprot id: A0A452DYS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DHX8
gene id: 9925:DHX8
uniprot id: A0A452DZC2
names: Subcellular Location Annotation
messages: Nucleus

9925:HK3
gene id: 9925:HK3
uniprot id: A0A452G057
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9925:DNA2
gene id: 9925:DNA2
uniprot id: A0A452F7L2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Mitochondrion
messages: Nucleus

9925:SHMT2
gene id: 9925:SHMT2
uniprot id: A0A452DPN1
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9925:LOC102176872
gene id: 9925:LOC102176872
uniprot id: A0A452G254
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.

9925:SDE2
gene id: 9925:SDE2
uniprot id: A0A452FN33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

9925:C17H12orf49
gene id: 9925:C17H12orf49
uniprot id: A0A452F0Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

9925:LALBA
gene id: 9925:LALBA
uniprot id: A5JSS8
uniprot id: P00712
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
messages: Mammary gland specific. Secreted in milk.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
messages: Secreted

9925:GJB3
gene id: 9925:GJB3
uniprot id: A0A452DMG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:TAF5L
gene id: 9925:TAF5L
uniprot id: A0A452GB45
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9925:LOC102185363
gene id: 9925:LOC102185363
uniprot id: A0A452EZ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

9925:ATP5E
gene id: 9925:ATP5E
uniprot id: A0A452FTG4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9925:PDSS2
gene id: 9925:PDSS2
uniprot id: A0A452EPC2
uniprot id: A0A452EPD3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9925:LOC102171791
gene id: 9925:LOC102171791
uniprot id: A0A452DRF3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:FAM19A1
gene id: 9925:FAM19A1
uniprot id: A0A8C2PHQ4
names: Similarity
messages: Belongs to the TAFA family.

9925:LOC108637158
gene id: 9925:LOC108637158
uniprot id: A0A452FVR4
names: Similarity
messages: Belongs to the TRM112 family.

9925:ACSS3
gene id: 9925:ACSS3
uniprot id: A0A452FSI0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:PRKD3
gene id: 9925:PRKD3
uniprot id: A0A452E1K4
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9925:LOC108633428
gene id: 9925:LOC108633428
uniprot id: A0A452EBH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DISP3
gene id: 9925:DISP3
uniprot id: A0A452FNM3
names: Subcellular Location Annotation
messages: Membrane

9925:TMEM54
gene id: 9925:TMEM54
uniprot id: A0A452DPL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9925:IFT57
gene id: 9925:IFT57
uniprot id: A0A452F428
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9925:OSBPL3
gene id: 9925:OSBPL3
uniprot id: A0A452EYT2
uniprot id: A0A452EYY4
uniprot id: A0A452EZ19
names: Similarity
messages: Belongs to the OSBP family.

9925:GCNT1
gene id: 9925:GCNT1
uniprot id: A0A452E6X6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9925:UBE2U
gene id: 9925:UBE2U
uniprot id: A0A452F661
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:B4GALNT2
gene id: 9925:B4GALNT2
uniprot id: A0A0K0PU76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

9925:KCNQ1
gene id: 9925:KCNQ1
uniprot id: A0A452FFW2
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Lateral cell membrane
messages: Membrane
messages: Membrane raft

9925:ABL1
gene id: 9925:ABL1
uniprot id: A0A452FJM7
uniprot id: A0A452FKI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:EPB41
gene id: 9925:EPB41
uniprot id: A0A452ELI5
uniprot id: A0A452ELK3
uniprot id: A0A452ELL7
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex

9925:BCO1
gene id: 9925:BCO1
uniprot id: A0A452FQT3
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9925:GJA9
gene id: 9925:GJA9
uniprot id: A0A452E0G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:LOC102180231
gene id: 9925:LOC102180231
uniprot id: A0A8C2NNM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9925:KCNV1
gene id: 9925:KCNV1
uniprot id: A0A452FUG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9925:SLC52A2
gene id: 9925:SLC52A2
uniprot id: A0A452EML4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9925:LOC100860781
gene id: 9925:LOC100860781
uniprot id: A5JST2
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9925:PIGO
gene id: 9925:PIGO
uniprot id: A0A452EIR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:WNT4
gene id: 9925:WNT4
uniprot id: A0A452G845
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:MRPS9
gene id: 9925:MRPS9
uniprot id: A0A452FNQ6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9925:ATP5D
gene id: 9925:ATP5D
uniprot id: A0A452GB32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

9925:RTN4IP1
gene id: 9925:RTN4IP1
uniprot id: A0A452E7Y7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9925:CREB5
gene id: 9925:CREB5
uniprot id: A0A452F1W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

9925:PKN3
gene id: 9925:PKN3
uniprot id: A0A452F748
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Nucleus

9925:APOE
gene id: 9925:APOE
uniprot id: A0A452FL25
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9925:LOC102180195
gene id: 9925:LOC102180195
uniprot id: A0A452DS00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GPD1
gene id: 9925:GPD1
uniprot id: A0A8C2QR84
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9925:LOC102175358
gene id: 9925:LOC102175358
uniprot id: A0A452DQR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9925:PROKR2
gene id: 9925:PROKR2
uniprot id: A0A452FFX6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:KRI1
gene id: 9925:KRI1
uniprot id: A0A452E9T9
names: Similarity
messages: Belongs to the KRI1 family.

9925:EYA2
gene id: 9925:EYA2
uniprot id: A0A452E5E1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9925:NOX4
gene id: 9925:NOX4
uniprot id: A0A452FK21
names: Subcellular Location Annotation
messages: Membrane

9925:SMC5
gene id: 9925:SMC5
uniprot id: A0A452F103
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9925:SLC28A1
gene id: 9925:SLC28A1
uniprot id: A0A452E2X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9925:RNF126
gene id: 9925:RNF126
uniprot id: A0A452FIK1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:GBE1
gene id: 9925:GBE1
uniprot id: A0A452G133
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

9925:TBX18
gene id: 9925:TBX18
uniprot id: A0A452EAQ4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:IRX2
gene id: 9925:IRX2
uniprot id: A0A452E776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9925:GRIK3
gene id: 9925:GRIK3
uniprot id: A0A452FK66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9925:LHCGR
gene id: 9925:LHCGR
uniprot id: A0A0G2YFV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9925:CXCL16
gene id: 9925:CXCL16
uniprot id: A0A8C2Y334
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Membrane

9925:ISL2
gene id: 9925:ISL2
uniprot id: A0A452ER63
names: Subcellular Location Annotation
messages: Nucleus

9925:FOXP1
gene id: 9925:FOXP1
uniprot id: A0A452F1P1
names: Subcellular Location Annotation
messages: Nucleus

9925:CKS2
gene id: 9925:CKS2
uniprot id: A0A452FMI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9925:HMGCR
gene id: 9925:HMGCR
uniprot id: A0A452ES40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

9925:SNRPA1
gene id: 9925:SNRPA1
uniprot id: A0A452EV18
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9925:EXOG
gene id: 9925:EXOG
uniprot id: A0A452EGM5
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9925:CCR10
gene id: 9925:CCR10
uniprot id: A0A452DS49
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:CHN1
gene id: 9925:CHN1
uniprot id: A0A452F0M4
names: Function
messages: GTPase-activating protein for p21-rac.

9925:NKX2-8
gene id: 9925:NKX2-8
uniprot id: A0A452FFC7
names: Subcellular Location Annotation
messages: Nucleus

9925:ZPBP
gene id: 9925:ZPBP
uniprot id: A0A452DWD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

9925:HACD2
gene id: 9925:HACD2
uniprot id: A0A452FUP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:TPPP3
gene id: 9925:TPPP3
uniprot id: A0A452FI38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: cytoskeleton

9925:CNOT9
gene id: 9925:CNOT9
uniprot id: A0A452G6W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9925:DDX47
gene id: 9925:DDX47
uniprot id: A0A452G5N4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9925:SCD
gene id: 9925:SCD
uniprot id: Q9BG81
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9925:LOC102187069
gene id: 9925:LOC102187069
uniprot id: A0A452EMI5
names: Similarity
messages: Belongs to the COX20 family.

9925:ENPP4
gene id: 9925:ENPP4
uniprot id: A0A452EEN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

9925:MAB21L1
gene id: 9925:MAB21L1
uniprot id: A0A452E920
names: Similarity
messages: Belongs to the mab-21 family.

9925:EML5
gene id: 9925:EML5
uniprot id: A0A452F503
uniprot id: A0A452F555
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
messages: cytoskeleton

9925:DMRT3
gene id: 9925:DMRT3
uniprot id: A0A452EEU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9925:CRK
gene id: 9925:CRK
uniprot id: A0A452DZ39
names: Similarity
messages: Belongs to the CRK family.

9925:QTRT2
gene id: 9925:QTRT2
uniprot id: A0A452EXQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9925:PDS5A
gene id: 9925:PDS5A
uniprot id: A0A452G6A0
names: Similarity
messages: Belongs to the PDS5 family.

9925:CASP8
gene id: 9925:CASP8
uniprot id: A0A452F8B6
uniprot id: A0A452F8D0
names: Similarity
messages: Belongs to the peptidase C14A family.

9925:NADK
gene id: 9925:NADK
uniprot id: A0A452FTW8
names: Similarity
messages: Belongs to the NAD kinase family.

9925:CMTM4
gene id: 9925:CMTM4
uniprot id: A0A452FKT2
names: Subcellular Location Annotation
messages: Membrane

9925:PHB
gene id: 9925:PHB
uniprot id: A0A452ECC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9925:B3GALT6
gene id: 9925:B3GALT6
uniprot id: A0A452E3Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:SYVN1
gene id: 9925:SYVN1
uniprot id: A0A452FVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRD1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:KXD1
gene id: 9925:KXD1
uniprot id: A0A452GAM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9925:RDH12
gene id: 9925:RDH12
uniprot id: A0A452G7T2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:MAP3K8
gene id: 9925:MAP3K8
uniprot id: A0A452F2I5
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9925:ALOXE3
gene id: 9925:ALOXE3
uniprot id: A0A452FTY8
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PSMD5
gene id: 9925:PSMD5
uniprot id: A0A452FI84
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9925:EVX1
gene id: 9925:EVX1
uniprot id: A0A452EPL2
names: Subcellular Location Annotation
messages: Nucleus

9925:MLLT11
gene id: 9925:MLLT11
uniprot id: A0A452DML1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9925:NUMB
gene id: 9925:NUMB
uniprot id: A0A452F030
uniprot id: A0A452F060
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9925:STK32C
gene id: 9925:STK32C
uniprot id: A0A452DK93
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:NUBP2
gene id: 9925:NUBP2
uniprot id: A0A8C2RXP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9925:LOC102188763
gene id: 9925:LOC102188763
uniprot id: A0A452E0R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PARD6B
gene id: 9925:PARD6B
uniprot id: A0A452FZS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9925:ENOPH1
gene id: 9925:ENOPH1
uniprot id: A0A452FUP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9925:NDUFA2
gene id: 9925:NDUFA2
uniprot id: A0A452GB25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:CUEDC2
gene id: 9925:CUEDC2
uniprot id: A0A452E651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9925:NIP7
gene id: 9925:NIP7
uniprot id: A0A452F965
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9925:PPP1R14D
gene id: 9925:PPP1R14D
uniprot id: A0A452E4M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9925:PRPF18
gene id: 9925:PRPF18
uniprot id: A0A452DLT2
uniprot id: A0A452DLT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9925:BPGM
gene id: 9925:BPGM
uniprot id: A0A452EPH7
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9925:ZNF202
gene id: 9925:ZNF202
uniprot id: A0A452G944
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102184120
gene id: 9925:LOC102184120
uniprot id: A0A452EV66
names: Similarity
messages: Belongs to the TCAF family.

9925:ZMPSTE24
gene id: 9925:ZMPSTE24
uniprot id: A0A452EKZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9925:SLC4A4
gene id: 9925:SLC4A4
uniprot id: A0A452FA81
uniprot id: A0A452FAC2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:LOC102186384
gene id: 9925:LOC102186384
uniprot id: A0A452E604
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC50A1
gene id: 9925:SLC50A1
uniprot id: A0A0F6T9B8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9925:FGFBP1
gene id: 9925:FGFBP1
uniprot id: A0A452DX68
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9925:WDR24
gene id: 9925:WDR24
uniprot id: A0A452FM91
names: Similarity
messages: Belongs to the WD repeat WDR24 family.

9925:POLR1B
gene id: 9925:POLR1B
uniprot id: A0A452EMC1
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9925:LOC102182581
gene id: 9925:LOC102182581
uniprot id: A0A452F700
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:ECHS1
gene id: 9925:ECHS1
uniprot id: A0A452DLQ9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9925:PBX2
gene id: 9925:PBX2
uniprot id: A0A452FK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9925:CDC14B
gene id: 9925:CDC14B
uniprot id: A0A452E195
uniprot id: A0A452E1A2
uniprot id: A0A452E1B0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9925:REM2
gene id: 9925:REM2
uniprot id: A0A452EAY7
names: Subcellular Location Annotation
messages: Cell membrane

9925:SEC22C
gene id: 9925:SEC22C
uniprot id: A0A452E0W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9925:TMOD2
gene id: 9925:TMOD2
uniprot id: A0A452FSM2
names: Subcellular Location Annotation
messages: cytoskeleton

9925:INSIG2
gene id: 9925:INSIG2
uniprot id: G1DGF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9925:VDAC1
gene id: 9925:VDAC1
uniprot id: A0A452FXM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft

9925:IMPA1
gene id: 9925:IMPA1
uniprot id: A0A452EUA9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9925:WBSCR17
gene id: 9925:WBSCR17
uniprot id: A0A452G1Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:DCTPP1
gene id: 9925:DCTPP1
uniprot id: A0A452DXU3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9925:DPYSL2
gene id: 9925:DPYSL2
uniprot id: A0A452G996
uniprot id: A0A452G9S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

9925:PGLYRP4
gene id: 9925:PGLYRP4
uniprot id: A0A8C2R3F9
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9925:LOC108636433
gene id: 9925:LOC108636433
uniprot id: A0A452DSQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FBXO25
gene id: 9925:FBXO25
uniprot id: A0A452FT48
names: Subcellular Location Annotation
messages: Nucleus

9925:MPC2
gene id: 9925:MPC2
uniprot id: A0A452E5Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9925:LOC102189434
gene id: 9925:LOC102189434
uniprot id: A0A452FCP1
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9925:EVC
gene id: 9925:EVC
uniprot id: A0A452FYH3
names: Subcellular Location Annotation
messages: Membrane
messages: cilium basal body
messages: cilium membrane

9925:CD53
gene id: 9925:CD53
uniprot id: A0A452EJY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:LOC102188238
gene id: 9925:LOC102188238
uniprot id: A0A452EBM2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:PRSS16
gene id: 9925:PRSS16
uniprot id: A0A452FYS3
names: Similarity
messages: Belongs to the peptidase S28 family.

9925:PLK2
gene id: 9925:PLK2
uniprot id: A0A452G4V7
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9925:KIF21A
gene id: 9925:KIF21A
uniprot id: A0A452G2J0
uniprot id: A0A452G2J3
uniprot id: A0A452G2M8
uniprot id: A0A452G2R3
uniprot id: A0A452G2R5
uniprot id: A0A452G2X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

9925:RRP1
gene id: 9925:RRP1
uniprot id: A0A452FGB8
names: Similarity
messages: Belongs to the RRP1 family.

9925:PSMD8
gene id: 9925:PSMD8
uniprot id: A0A452G754
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

9925:IQCD
gene id: 9925:IQCD
uniprot id: A0A452F2L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9925:TJP2
gene id: 9925:TJP2
uniprot id: A0A452E1R7
uniprot id: A0A452E1S5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9925:GJC2
gene id: 9925:GJC2
uniprot id: A0A452EAK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:SMIM19
gene id: 9925:SMIM19
uniprot id: A0A452E3N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9925:REM1
gene id: 9925:REM1
uniprot id: A0A452ENP9
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9925:SCARB1
gene id: 9925:SCARB1
uniprot id: A0A452F386
names: Similarity
messages: Belongs to the CD36 family.

9925:PRCP
gene id: 9925:PRCP
uniprot id: A0A452E754
names: Similarity
messages: Belongs to the peptidase S28 family.

9925:LOC102171408
gene id: 9925:LOC102171408
uniprot id: A0A452DSB8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CEPT1
gene id: 9925:CEPT1
uniprot id: A0A452FR90
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9925:FAM91A1
gene id: 9925:FAM91A1
uniprot id: A0A452DYX3
names: Similarity
messages: Belongs to the FAM91 family.

9925:ADGRD1
gene id: 9925:ADGRD1
uniprot id: A0A452FXM2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:RPS14
gene id: 9925:RPS14
uniprot id: A0A452ECV2
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9925:DPAGT1
gene id: 9925:DPAGT1
uniprot id: A0A452EAI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LOC102173997
gene id: 9925:LOC102173997
uniprot id: A0A0C4Y1X3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9925:STAMBP
gene id: 9925:STAMBP
uniprot id: A0A452G1N4
names: Similarity
messages: Belongs to the peptidase M67C family.

9925:LOC102175603
gene id: 9925:LOC102175603
uniprot id: A0A452DUK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RAB29
gene id: 9925:RAB29
uniprot id: A0A452FSA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9925:CERS2
gene id: 9925:CERS2
uniprot id: A0A452FTH2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9925:TTC4
gene id: 9925:TTC4
uniprot id: A0A452FDT4
names: Similarity
messages: Belongs to the TTC4 family.

9925:CDC42SE1
gene id: 9925:CDC42SE1
uniprot id: A0A452DYH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9925:LOC102191036
gene id: 9925:LOC102191036
uniprot id: A0A452DPP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ABRACL
gene id: 9925:ABRACL
uniprot id: A0A452F910
names: Similarity
messages: Belongs to the costars family.

9925:TAF6
gene id: 9925:TAF6
uniprot id: A0A452GBB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9925:SYS1
gene id: 9925:SYS1
uniprot id: A0A452FFV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9925:PEX14
gene id: 9925:PEX14
uniprot id: A0A8C2Y0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

9925:LOC102184830
gene id: 9925:LOC102184830
uniprot id: A0A452DZI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PLPPR3
gene id: 9925:PLPPR3
uniprot id: A0A452DXY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9925:CLTA
gene id: 9925:CLTA
uniprot id: A0A452ETA7
uniprot id: A0A452EU53
uniprot id: A0A8C2PBV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9925:LOC102182595
gene id: 9925:LOC102182595
uniprot id: A0A8C2R572
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CCNJL
gene id: 9925:CCNJL
uniprot id: A0A452F9B6
names: Similarity
messages: Belongs to the cyclin family.

9925:GPR65
gene id: 9925:GPR65
uniprot id: A0A8C2NIC8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:LOC102187772
gene id: 9925:LOC102187772
uniprot id: A0A8C2NYE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102171149
gene id: 9925:LOC102171149
uniprot id: A0A452F096
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9925:MRPL18
gene id: 9925:MRPL18
uniprot id: A0A452FST3
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9925:PRKAR1A
gene id: 9925:PRKAR1A
uniprot id: A0A452E8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9925:PCCA
gene id: 9925:PCCA
uniprot id: A0A452DUI2
names: Subcellular Location Annotation
messages: Mitochondrion matrix

9925:SGTB
gene id: 9925:SGTB
uniprot id: A0A452EQA8
names: Similarity
messages: Belongs to the SGT family.

9925:PTPN4
gene id: 9925:PTPN4
uniprot id: A0A452ECC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9925:DDI1
gene id: 9925:DDI1
uniprot id: A0A8C2XXW0
names: Similarity
messages: Belongs to the DDI1 family.

9925:WFIKKN2
gene id: 9925:WFIKKN2
uniprot id: A0A452FFV0
names: Similarity
messages: Belongs to the WFIKKN family.

9925:RGS5
gene id: 9925:RGS5
uniprot id: A0A452FPM6
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9925:LRRFIP1
gene id: 9925:LRRFIP1
uniprot id: A0A452DSK9
names: Similarity
messages: Belongs to the LRRFIP family.

9925:BRMS1
gene id: 9925:BRMS1
uniprot id: A0A8C2RAE6
names: Subcellular Location Annotation
messages: Nucleus

9925:GUF1
gene id: 9925:GUF1
uniprot id: A0A452E339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

9925:USP14
gene id: 9925:USP14
uniprot id: A0A452DSP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9925:ALDH6A1
gene id: 9925:ALDH6A1
uniprot id: A0A452EAJ9
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9925:VTI1B
gene id: 9925:VTI1B
uniprot id: A0A452G8B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9925:HSP90B1
gene id: 9925:HSP90B1
uniprot id: A0A452E1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9925:ADSS
gene id: 9925:ADSS
uniprot id: A0A452F9N2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9925:OSBPL6
gene id: 9925:OSBPL6
uniprot id: A0A452DY78
uniprot id: A0A452DYE6
uniprot id: A0A452DYR6
uniprot id: A0A452DYV3
names: Similarity
messages: Belongs to the OSBP family.

9925:SEMA4D
gene id: 9925:SEMA4D
uniprot id: A0A452DLX7
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC108636621
gene id: 9925:LOC108636621
uniprot id: A0A452DN65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:POU3F1
gene id: 9925:POU3F1
uniprot id: A0A452DUK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9925:PI4K2A
gene id: 9925:PI4K2A
uniprot id: A0A452F9T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9925:MRPL24
gene id: 9925:MRPL24
uniprot id: A0A452ENK2
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9925:KCTD13
gene id: 9925:KCTD13
uniprot id: A0A452FU28
names: Similarity
messages: Belongs to the BACURD family.

9925:CPNE5
gene id: 9925:CPNE5
uniprot id: A0A452DQT2
uniprot id: A0A452DQU7
names: Similarity
messages: Belongs to the copine family.

9925:EMX2
gene id: 9925:EMX2
uniprot id: A0A452FU68
names: Subcellular Location Annotation
messages: Nucleus

9925:RAB4B
gene id: 9925:RAB4B
uniprot id: A0A452DQG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9925:MEA1
gene id: 9925:MEA1
uniprot id: A0A452G311
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

9925:PRPF3
gene id: 9925:PRPF3
uniprot id: A0A452ERP9
uniprot id: A0A8C2N6A3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9925:DEUP1
gene id: 9925:DEUP1
uniprot id: A0A452F4F4
uniprot id: A0A452F534
uniprot id: A0A452F567
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Cytoplasm

9925:ABCC9
gene id: 9925:ABCC9
uniprot id: A0A452G8L7
uniprot id: A0A452G8M6
names: Subunit
messages: Interacts with KCNJ11.

9925:HSD17B3
gene id: 9925:HSD17B3
uniprot id: A0A452GAM8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:MAP34-B
gene id: 9925:MAP34-B
uniprot id: P82017
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9925:C14H8orf33
gene id: 9925:C14H8orf33
uniprot id: A0A452DNI0
names: Similarity
messages: Belongs to the UPF0488 family.

9925:ENSA
gene id: 9925:ENSA
uniprot id: A0A452E897
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9925:RNFT1
gene id: 9925:RNFT1
uniprot id: A0A452F858
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102189034
gene id: 9925:LOC102189034
uniprot id: A0A452E9U1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:ADCK5
gene id: 9925:ADCK5
uniprot id: A0A8C2RPP6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9925:LRP2
gene id: 9925:LRP2
uniprot id: A0A452F7C6
uniprot id: A0A452F7H5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:CFH
gene id: 9925:CFH
uniprot id: A0A452FF76
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SLC26A5
gene id: 9925:SLC26A5
uniprot id: A0A452FVN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ.

9925:TONSL
gene id: 9925:TONSL
uniprot id: A0A452ETD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

9925:RXRB
gene id: 9925:RXRB
uniprot id: A0A452E335
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9925:CAV3
gene id: 9925:CAV3
uniprot id: A0A452E251
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola
messages: sarcolemma

9925:GHRL
gene id: 9925:GHRL
uniprot id: Q6BEG7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Amidation of Leu-97 is essential for obestatin activity.
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity).
messages: O-octanoylated by GOAT/MBOAT4 (By similarity). O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
messages: Secreted

9925:GLI3
gene id: 9925:GLI3
uniprot id: A0A452EPR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus

9925:TRPC4
gene id: 9925:TRPC4
uniprot id: A0A452DT91
names: Subcellular Location Annotation
messages: Membrane

9925:EIF2S1
gene id: 9925:EIF2S1
uniprot id: A0A452E6F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9925:KEF96 p06
gene id: 9925:KEF96_p06
uniprot id: D0VEG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

9925:GTF2I
gene id: 9925:GTF2I
uniprot id: A0A452DX80
uniprot id: A0A452DXC3
uniprot id: A0A452DXG8
names: Subcellular Location Annotation
messages: Nucleus

9925:CWC25
gene id: 9925:CWC25
uniprot id: A0A452EPF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9925:IL12RB2
gene id: 9925:IL12RB2
uniprot id: A0A452G9D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9925:PLA2G2A
gene id: 9925:PLA2G2A
uniprot id: A0A452FN06
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9925:ZNF263
gene id: 9925:ZNF263
uniprot id: A0A452FHE1
names: Subcellular Location Annotation
messages: Nucleus

9925:CCSER2
gene id: 9925:CCSER2
uniprot id: A0A452FK09
uniprot id: A0A452FKF4
names: Similarity
messages: Belongs to the CCSER family.

9925:LOC102175783
gene id: 9925:LOC102175783
uniprot id: A0A452EV45
uniprot id: A0A8C2Y0A9
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9925:FAM228B
gene id: 9925:FAM228B
uniprot id: A0A452FQE6
names: Similarity
messages: Belongs to the FAM228 family.

9925:FAM98B
gene id: 9925:FAM98B
uniprot id: A0A452EVP5
names: Similarity
messages: Belongs to the FAM98 family.

9925:SEPP1
gene id: 9925:SEPP1
uniprot id: H6WVW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein P family.
messages: Secreted

9925:SLC7A7
gene id: 9925:SLC7A7
uniprot id: A0A452FNJ4
names: Subcellular Location Annotation
messages: Membrane

9925:PCSK5
gene id: 9925:PCSK5
uniprot id: A0A452DQZ9
uniprot id: A0A452DR00
uniprot id: A0A452DRA5
names: Similarity
messages: Belongs to the peptidase S8 family.

9925:TMEM216
gene id: 9925:TMEM216
uniprot id: A0A8C2SA14
names: Subcellular Location Annotation
messages: Membrane

9925:MTFR1L
gene id: 9925:MTFR1L
uniprot id: A0A8C2N8Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9925:ISL1
gene id: 9925:ISL1
uniprot id: A0A452FNW4
names: Subcellular Location Annotation
messages: Nucleus

9925:DLK2
gene id: 9925:DLK2
uniprot id: A0A452DR75
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MDM1
gene id: 9925:MDM1
uniprot id: A0A452FTG0
uniprot id: A0A452FTI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9925:ABCC6
gene id: 9925:ABCC6
uniprot id: A0A452FPB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9925:GSC
gene id: 9925:GSC
uniprot id: A0A452FMK4
names: Subcellular Location Annotation
messages: Nucleus

9925:MRPS18B
gene id: 9925:MRPS18B
uniprot id: A0A452FKR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

9925:PHTF2
gene id: 9925:PHTF2
uniprot id: A0A452EIV9
names: Subcellular Location Annotation
messages: Membrane

9925:CNOT6L
gene id: 9925:CNOT6L
uniprot id: A0A452DSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9925:GSTZ1
gene id: 9925:GSTZ1
uniprot id: A0A8C2NPS8
uniprot id: A0A8C2NQL8
uniprot id: A0A8C2QTU0
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9925:ARHGEF28
gene id: 9925:ARHGEF28
uniprot id: A0A452EJG7
uniprot id: A0A452EJI7
uniprot id: A0A452EJR0
uniprot id: A0A452EK20
names: Subcellular Location Annotation
messages: Cytoplasm

9925:HOXA7
gene id: 9925:HOXA7
uniprot id: A0A452FLE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:GPR161
gene id: 9925:GPR161
uniprot id: A0A452FID6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:UNC5B
gene id: 9925:UNC5B
uniprot id: A0A452ECC3
uniprot id: A0A452ECQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9925:SEPT11
gene id: 9925:SEPT11
uniprot id: A0A452FGM9
uniprot id: A0A8C2NBQ8
uniprot id: A0A8C2NBS0
uniprot id: A0A8C2QRP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9925:LOC102185550
gene id: 9925:LOC102185550
uniprot id: A0A452EBJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ZNF165
gene id: 9925:ZNF165
uniprot id: A0A452E2X6
names: Subcellular Location Annotation
messages: Nucleus

9925:TMEM145
gene id: 9925:TMEM145
uniprot id: A0A452DPF7
names: Subcellular Location Annotation
messages: Membrane

9925:RPS11
gene id: 9925:RPS11
uniprot id: A0A452GB27
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9925:LOC102183418
gene id: 9925:LOC102183418
uniprot id: A0A452DRM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CHPF
gene id: 9925:CHPF
uniprot id: A0A452E9P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9925:TMEM205
gene id: 9925:TMEM205
uniprot id: A0A452DU54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9925:MYLK4
gene id: 9925:MYLK4
uniprot id: A0A452DVZ5
uniprot id: A0A452DW64
uniprot id: A0A452DW74
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:S100A5
gene id: 9925:S100A5
uniprot id: A0A452G563
names: Similarity
messages: Belongs to the S-100 family.

9925:ZFP69
gene id: 9925:ZFP69
uniprot id: A0A452DX37
names: Subcellular Location Annotation
messages: Nucleus

9925:VARS2
gene id: 9925:VARS2
uniprot id: A0A452DV93
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:LOC102184252
gene id: 9925:LOC102184252
uniprot id: A0A452EC23
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:LOC102175243
gene id: 9925:LOC102175243
uniprot id: A0A452DT72
names: Similarity
messages: Belongs to the histone H2B family.

9925:XKR5
gene id: 9925:XKR5
uniprot id: A0A452F4Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9925:SEMA4G
gene id: 9925:SEMA4G
uniprot id: A0A452F197
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PLA2G5
gene id: 9925:PLA2G5
uniprot id: A0A452F8H5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9925:DBR1
gene id: 9925:DBR1
uniprot id: A0A452G9X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

9925:LOC102172438
gene id: 9925:LOC102172438
uniprot id: A0A452F5X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9925:TNP2
gene id: 9925:TNP2
uniprot id: A0A8C2RKQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Nucleus
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.

9925:MAN2A1
gene id: 9925:MAN2A1
uniprot id: V9XY47
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9925:PEMT
gene id: 9925:PEMT
uniprot id: A0A452DY36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9925:SESN1
gene id: 9925:SESN1
uniprot id: A0A452F1W9
uniprot id: A0A452F234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9925:CDC42
gene id: 9925:CDC42
uniprot id: A0A452EIX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: centrosome

9925:PTPRE
gene id: 9925:PTPRE
uniprot id: A0A452FA03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9925:LOC102180307
gene id: 9925:LOC102180307
uniprot id: A0A452DWU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC102185401
gene id: 9925:LOC102185401
uniprot id: A0A452FJ07
names: Similarity
messages: Belongs to the serpin family.

9925:LRRC8D
gene id: 9925:LRRC8D
uniprot id: A0A452E0N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9925:SNX30
gene id: 9925:SNX30
uniprot id: A0A452DQ61
names: Similarity
messages: Belongs to the sorting nexin family.

9925:DSC3
gene id: 9925:DSC3
uniprot id: A0A452FKJ7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9925:IQSEC3
gene id: 9925:IQSEC3
uniprot id: A0A452EW72
uniprot id: A0A452EW76
names: Similarity
messages: Belongs to the BRAG family.

9925:GAMT
gene id: 9925:GAMT
uniprot id: A0A452E1U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.
messages: Monomer.

9925:FAM49A
gene id: 9925:FAM49A
uniprot id: A0A452F6L7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9925:PTGS1
gene id: 9925:PTGS1
uniprot id: A0A452DMH9
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:C16H1orf27
gene id: 9925:C16H1orf27
uniprot id: A0A8C2SJW7
uniprot id: A0A8C2SM42
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9925:NFKB1
gene id: 9925:NFKB1
uniprot id: A0A452DXG3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:SEC11C
gene id: 9925:SEC11C
uniprot id: A0A452DTE6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:DNASE1L3
gene id: 9925:DNASE1L3
uniprot id: A0A452FMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Nucleus envelope
messages: Zymogen granule

9925:DEFB123
gene id: 9925:DEFB123
uniprot id: A0A8C2NQJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9925:LOC102170588
gene id: 9925:LOC102170588
uniprot id: A0A452FXN2
uniprot id: A0A452FXN8
names: Similarity
messages: Belongs to the apolipoprotein L family.

9925:LOC102183415
gene id: 9925:LOC102183415
uniprot id: A0A452DS91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RPS27A
gene id: 9925:RPS27A
uniprot id: A0A452EHZ1
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9925:FREM2
gene id: 9925:FREM2
uniprot id: A0A452FMB1
names: Similarity
messages: Belongs to the FRAS1 family.

9925:SLC10A5
gene id: 9925:SLC10A5
uniprot id: A0A452DRD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9925:CACNA2D3
gene id: 9925:CACNA2D3
uniprot id: A0A452FS12
uniprot id: A0A452FSB0
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9925:TM9SF3
gene id: 9925:TM9SF3
uniprot id: A0A452EBK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9925:PSMB6
gene id: 9925:PSMB6
uniprot id: A0A452FSD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9925:CHST2
gene id: 9925:CHST2
uniprot id: A0A452E4Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9925:GNG10
gene id: 9925:GNG10
uniprot id: A0A452ERM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:TNFRSF11B
gene id: 9925:TNFRSF11B
uniprot id: A0A452FZ89
names: Caution
names: Function
names: Subunit
messages: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PSMB4
gene id: 9925:PSMB4
uniprot id: A0A452FAZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9925:LOC102189595
gene id: 9925:LOC102189595
uniprot id: A0A452FKK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

9925:RBM47
gene id: 9925:RBM47
uniprot id: A0A452G6B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Nucleus

9925:DACT3
gene id: 9925:DACT3
uniprot id: A0A452FJY8
names: Similarity
messages: Belongs to the dapper family.

9925:OTOP2
gene id: 9925:OTOP2
uniprot id: A0A452EG55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9925:DCLK1
gene id: 9925:DCLK1
uniprot id: A0A452FQ21
uniprot id: A0A452FQ44
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9925:GNPNAT1
gene id: 9925:GNPNAT1
uniprot id: A0A452FFF1
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9925:CDC25C
gene id: 9925:CDC25C
uniprot id: A0A8C2QVZ8
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9925:TOR4A
gene id: 9925:TOR4A
uniprot id: A0A452E3F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Membrane

9925:PANX1
gene id: 9925:PANX1
uniprot id: A0A452E6G1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9925:DERL3
gene id: 9925:DERL3
uniprot id: A0A452EMW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9925:HNF1B
gene id: 9925:HNF1B
uniprot id: A0A8C2RXK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9925:VRK1
gene id: 9925:VRK1
uniprot id: A0A452FQP4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:GSG1L
gene id: 9925:GSG1L
uniprot id: A0A452F2E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9925:FZD3
gene id: 9925:FZD3
uniprot id: A0A452FTY7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:ATP2C1
gene id: 9925:ATP2C1
uniprot id: A0A452ERZ3
uniprot id: A0A452ESF4
uniprot id: A0A452ESG9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

9925:LIPE
gene id: 9925:LIPE
uniprot id: A0A452FF98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Lipid droplet
messages: caveola
messages: cytosol

9925:LIN28A
gene id: 9925:LIN28A
uniprot id: A0A075TUV4
uniprot id: A0A452FF48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9925:CNIH2
gene id: 9925:CNIH2
uniprot id: A0A452EZV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9925:TM9SF4
gene id: 9925:TM9SF4
uniprot id: A0A452EE59
uniprot id: A0A452EEF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9925:MAX
gene id: 9925:MAX
uniprot id: A0A8C2XXL2
names: Similarity
messages: Belongs to the MAX family.

9925:THBS2
gene id: 9925:THBS2
uniprot id: A0A452EWD5
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CREG2
gene id: 9925:CREG2
uniprot id: A0A452E2T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9925:ARFGEF1
gene id: 9925:ARFGEF1
uniprot id: A0A452EAG5
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9925:RFC4
gene id: 9925:RFC4
uniprot id: A0A452FFQ5
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9925:LOC102171763
gene id: 9925:LOC102171763
uniprot id: A0A452E9E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CCL24
gene id: 9925:CCL24
uniprot id: A0A452E572
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9925:ANO3
gene id: 9925:ANO3
uniprot id: A0A452FGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

9925:SLC4A7
gene id: 9925:SLC4A7
uniprot id: A0A452ERM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9925:RSAD1
gene id: 9925:RSAD1
uniprot id: A0A452FZ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Mitochondrion

9925:LOC102177329
gene id: 9925:LOC102177329
uniprot id: A0A452FHT9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:ATP5G3
gene id: 9925:ATP5G3
uniprot id: A0A452F301
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9925:GLIPR1
gene id: 9925:GLIPR1
uniprot id: A0A452FXP4
names: Similarity
messages: Belongs to the CRISP family.

9925:TPMT
gene id: 9925:TPMT
uniprot id: A0A452DS26
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9925:TRAK2
gene id: 9925:TRAK2
uniprot id: A0A452G8K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9925:NMB
gene id: 9925:NMB
uniprot id: A0A452E2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9925:CRYAB
gene id: 9925:CRYAB
uniprot id: A0A452EJN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9925:LOC102174956
gene id: 9925:LOC102174956
uniprot id: A0A452E544
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DDIT3
gene id: 9925:DDIT3
uniprot id: M1PEQ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9925:IP6K3
gene id: 9925:IP6K3
uniprot id: A0A452FHA3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9925:SMAD6
gene id: 9925:SMAD6
uniprot id: A0A452ECS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9925:MFAP3L
gene id: 9925:MFAP3L
uniprot id: A0A452EA91
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:EIF5
gene id: 9925:EIF5
uniprot id: A0A452FHV2
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

9925:FAM229A
gene id: 9925:FAM229A
uniprot id: A0A452ES98
names: Similarity
messages: Belongs to the FAM229 family.

9925:USP39
gene id: 9925:USP39
uniprot id: A0A452FH76
names: Subcellular Location Annotation
messages: Nucleus

9925:PAG-2
gene id: 9925:PAG-2
uniprot id: Q9TTX4
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:AREG
gene id: 9925:AREG
uniprot id: A0A452ES87
uniprot id: A0A452ETM3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MARK2
gene id: 9925:MARK2
uniprot id: A0A452FBI1
uniprot id: A0A8C2RB05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9925:STAR
gene id: 9925:STAR
uniprot id: A0A452EZV5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9925:PLPP4
gene id: 9925:PLPP4
uniprot id: A0A452EI90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9925:PLIN1
gene id: 9925:PLIN1
uniprot id: A0A452FW84
names: Similarity
messages: Belongs to the perilipin family.

9925:DEDD
gene id: 9925:DEDD
uniprot id: A0A452G415
names: Subcellular Location Annotation
messages: nucleolus

9925:F13B
gene id: 9925:F13B
uniprot id: A0A452FLA7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TMEM94
gene id: 9925:TMEM94
uniprot id: A0A452EIL6
names: Subcellular Location Annotation
messages: Membrane

9925:SERPINA5
gene id: 9925:SERPINA5
uniprot id: A0A452F014
names: Similarity
messages: Belongs to the serpin family.

9925:RDH5
gene id: 9925:RDH5
uniprot id: A0A452EKV5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:FAM221B
gene id: 9925:FAM221B
uniprot id: A0A8C2PGB8
names: Similarity
messages: Belongs to the FAM221 family.

9925:CPSF7
gene id: 9925:CPSF7
uniprot id: A0A452ELZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9925:PTGER4
gene id: 9925:PTGER4
uniprot id: A0A8C2QY70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9925:CAPZA3
gene id: 9925:CAPZA3
uniprot id: A0A452DRW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9925:KEF96 p09
gene id: 9925:KEF96_p09
uniprot id: D0VEF8
uniprot id: Q32643
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9925:DDA1
gene id: 9925:DDA1
uniprot id: A0A8C2NZX9
names: Similarity
messages: Belongs to the DDA1 family.

9925:AHR
gene id: 9925:AHR
uniprot id: A0A452F9J9
names: Subcellular Location Annotation
messages: Cytoplasm

9925:PFDN6
gene id: 9925:PFDN6
uniprot id: A0A452FHF8
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9925:SUGP1
gene id: 9925:SUGP1
uniprot id: A0A452FX71
names: Subcellular Location Annotation
messages: Nucleus

9925:RAD54L2
gene id: 9925:RAD54L2
uniprot id: A0A452DYL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9925:PPP4C
gene id: 9925:PPP4C
uniprot id: A0A452FMX8
names: Similarity
messages: Belongs to the PPP phosphatase family.

9925:HOXB9
gene id: 9925:HOXB9
uniprot id: A0A452FQ53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9925:OPALIN
gene id: 9925:OPALIN
uniprot id: A0A452EYA0
uniprot id: A0A8C2RNL9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9925:LOC102187855
gene id: 9925:LOC102187855
uniprot id: A0A452E324
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RUNX2
gene id: 9925:RUNX2
uniprot id: A0A452ETJ7
uniprot id: A0A452EU36
uniprot id: A0A452EU42
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9925:ME1
gene id: 9925:ME1
uniprot id: A0A452FQE3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9925:NPHS2
gene id: 9925:NPHS2
uniprot id: A0A452DPB8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9925:LOC108633243
gene id: 9925:LOC108633243
uniprot id: A0A452DNT4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Monomer.
messages: Secreted

9925:LBR
gene id: 9925:LBR
uniprot id: A0A452EHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9925:PDE7A
gene id: 9925:PDE7A
uniprot id: A0A452EXE4
uniprot id: A0A452EXF7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:KEF96 p12
gene id: 9925:KEF96_p12
uniprot id: D0VEF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9925:PTP4A1
gene id: 9925:PTP4A1
uniprot id: A0A452F1P7
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9925:HOXB7
gene id: 9925:HOXB7
uniprot id: A0A452F107
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:CALB1
gene id: 9925:CALB1
uniprot id: A0A452FGU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

9925:LOC102191750
gene id: 9925:LOC102191750
uniprot id: A0A452DYV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:IRX1
gene id: 9925:IRX1
uniprot id: A0A452F2J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9925:APTX
gene id: 9925:APTX
uniprot id: A0A452EE15
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

9925:SLC26A3
gene id: 9925:SLC26A3
uniprot id: A0A452GB98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Chloride/bicarbonate exchanger.
messages: Membrane

9925:ADNP
gene id: 9925:ADNP
uniprot id: A0A452G9V2
names: Subcellular Location Annotation
messages: Nucleus

9925:HCN1
gene id: 9925:HCN1
uniprot id: A0A452G059
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9925:STT3B
gene id: 9925:STT3B
uniprot id: A0A452EGI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9925:EEF1G
gene id: 9925:EEF1G
uniprot id: A0A452FNW0
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9925:TPRKB
gene id: 9925:TPRKB
uniprot id: A0A452FL41
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9925:EIF1AD
gene id: 9925:EIF1AD
uniprot id: A0A452EHP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9925:FGF18
gene id: 9925:FGF18
uniprot id: A0A452E8C6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:SDC4
gene id: 9925:SDC4
uniprot id: A0A452F549
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9925:PCMTD2
gene id: 9925:PCMTD2
uniprot id: A0A452F6S7
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9925:ACY1
gene id: 9925:ACY1
uniprot id: A0A452EUS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

9925:PITX3
gene id: 9925:PITX3
uniprot id: A0A452DR02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9925:DLL1
gene id: 9925:DLL1
uniprot id: A0A452FF54
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9925:BAP1
gene id: 9925:BAP1
uniprot id: A0A452FLD0
names: Similarity
messages: Belongs to the peptidase C12 family.

9925:EIF3E
gene id: 9925:EIF3E
uniprot id: A0A452DRD5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.

9925:RAB3C
gene id: 9925:RAB3C
uniprot id: A0A452DLV5
uniprot id: A0A452DLV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9925:NXF1
gene id: 9925:NXF1
uniprot id: A0A452E2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9925:FAM46B
gene id: 9925:FAM46B
uniprot id: A0A452F9V9
names: Similarity
messages: Belongs to the TENT family.

9925:DMRTA2
gene id: 9925:DMRTA2
uniprot id: A0A452EK21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9925:ME3
gene id: 9925:ME3
uniprot id: A0A452EKF4
uniprot id: A0A452EKP7
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9925:MOV10
gene id: 9925:MOV10
uniprot id: A0A452FNR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9925:DHODH
gene id: 9925:DHODH
uniprot id: A0A452DLT1
uniprot id: A0A452DLT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9925:LOC102181492
gene id: 9925:LOC102181492
uniprot id: A0A452E4B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TXLNA
gene id: 9925:TXLNA
uniprot id: A0A452G8A3
names: Similarity
messages: Belongs to the taxilin family.

9925:SEMA4B
gene id: 9925:SEMA4B
uniprot id: A0A452FKH0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ADORA2B
gene id: 9925:ADORA2B
uniprot id: A0A452EWS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9925:C6H4orf48
gene id: 9925:C6H4orf48
uniprot id: A0A452DN45
names: Subcellular Location Annotation
messages: Secreted

9925:GH1
gene id: 9925:GH1
uniprot id: P67931
uniprot id: Q19AP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9925:LOC108637116
gene id: 9925:LOC108637116
uniprot id: A0A452DNU6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NPL
gene id: 9925:NPL
uniprot id: A0A452FZI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9925:IER5L
gene id: 9925:IER5L
uniprot id: A0A452DV02
names: Similarity
messages: Belongs to the IER family.

9925:MSMB
gene id: 9925:MSMB
uniprot id: A0A8C2S3Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9925:DRAXIN
gene id: 9925:DRAXIN
uniprot id: A0A8C2XZ07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the draxin family.
messages: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
messages: Interacts with LRP6.
messages: Secreted

9925:OLFM3
gene id: 9925:OLFM3
uniprot id: A0A452DWG8
uniprot id: A0A452DWI0
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9925:KHDRBS2
gene id: 9925:KHDRBS2
uniprot id: A0A452FXT7
names: Similarity
messages: Belongs to the KHDRBS family.

9925:ESCO1
gene id: 9925:ESCO1
uniprot id: A0A452EX35
names: Subcellular Location Annotation
messages: Nucleus

9925:RNF40
gene id: 9925:RNF40
uniprot id: A0A452DWC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9925:GATA6
gene id: 9925:GATA6
uniprot id: A0A452F7D3
names: Subcellular Location Annotation
messages: Nucleus

9925:FANCC
gene id: 9925:FANCC
uniprot id: A0A452FJZ7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.
messages: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
messages: Nucleus

9925:CHMP6
gene id: 9925:CHMP6
uniprot id: A0A452DP05
names: Similarity
messages: Belongs to the SNF7 family.

9925:NTF3
gene id: 9925:NTF3
uniprot id: A0A452EC08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9925:SLC9A3
gene id: 9925:SLC9A3
uniprot id: A0A452FGZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9925:FGFR2
gene id: 9925:FGFR2
uniprot id: A0A452F2R9
uniprot id: A0A452F2V8
uniprot id: A0A452F370
uniprot id: A0A452F397
uniprot id: A0A452F3C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9925:FAM118B
gene id: 9925:FAM118B
uniprot id: A0A8C2R5S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

9925:LOC102183874
gene id: 9925:LOC102183874
uniprot id: A0A452EMP1
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9925:MICALL1
gene id: 9925:MICALL1
uniprot id: A0A452EMC2
names: Subcellular Location Annotation
messages: Membrane

9925:PGGT1B
gene id: 9925:PGGT1B
uniprot id: A0A452G303
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9925:RALYL
gene id: 9925:RALYL
uniprot id: A0A8C2R353
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9925:C27H4orf47
gene id: 9925:C27H4orf47
uniprot id: A0A452FTX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0602 family.
messages: centrosome

9925:STEAP1
gene id: 9925:STEAP1
uniprot id: A0A452DRR2
names: Subcellular Location Annotation
messages: Membrane

9925:SERPINB11
gene id: 9925:SERPINB11
uniprot id: A0A452FCM3
names: Similarity
messages: Belongs to the serpin family.

9925:ZDHHC13
gene id: 9925:ZDHHC13
uniprot id: A0A452G0P0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:SEH1L
gene id: 9925:SEH1L
uniprot id: A0A452DSH5
uniprot id: A0A452DSM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9925:TAS1R2
gene id: 9925:TAS1R2
uniprot id: A0A452FBZ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:ATP13A5
gene id: 9925:ATP13A5
uniprot id: A0A452E6Y4
uniprot id: A0A452E709
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:FLT3
gene id: 9925:FLT3
uniprot id: A0A452DSQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Membrane

9925:SLC35A1
gene id: 9925:SLC35A1
uniprot id: A0A452F3M2
uniprot id: A0A8C2NPT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9925:LOC108633190
gene id: 9925:LOC108633190
uniprot id: A0A452FPF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9925:DPP4
gene id: 9925:DPP4
uniprot id: A0A452FGG5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane raft
messages: invadopodium membrane
messages: lamellipodium membrane

9925:SLC48A1
gene id: 9925:SLC48A1
uniprot id: A0A452EBG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
messages: Lysosome membrane
messages: Membrane

9925:KRT78
gene id: 9925:KRT78
uniprot id: A0A452G5G9
names: Similarity
messages: Belongs to the intermediate filament family.

9925:UNC13B
gene id: 9925:UNC13B
uniprot id: A0A452EDY0
names: Subcellular Location Annotation
messages: Cytoplasm

9925:PAX6
gene id: 9925:PAX6
uniprot id: A0A452FSU9
uniprot id: A0A8C2NYT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:DGAT1
gene id: 9925:DGAT1
uniprot id: A0A193SI68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9925:VCL
gene id: 9925:VCL
uniprot id: A0A452DKU9
uniprot id: A0A452DLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9925:LOC102181592
gene id: 9925:LOC102181592
uniprot id: A0A452FQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9925:USP2
gene id: 9925:USP2
uniprot id: A0A452DNV5
uniprot id: A0A452DNZ3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9925:C25H16orf72
gene id: 9925:C25H16orf72
uniprot id: A0A452DWH3
names: Similarity
messages: Belongs to the TAPR1 family.

9925:LOC102176137
gene id: 9925:LOC102176137
uniprot id: A0A452E0K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC108636617
gene id: 9925:LOC108636617
uniprot id: A0A452DN00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:PCOLCE
gene id: 9925:PCOLCE
uniprot id: A0A452EHN1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:SIKE1
gene id: 9925:SIKE1
uniprot id: A0A452ELT8
names: Similarity
messages: Belongs to the SIKE family.

9925:GABRA1
gene id: 9925:GABRA1
uniprot id: A0A452F9D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:HSD17B4
gene id: 9925:HSD17B4
uniprot id: A0A452EBH2
names: Subcellular Location Annotation
messages: Peroxisome

9925:PCNX4
gene id: 9925:PCNX4
uniprot id: A0A452GB60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9925:MPDZ
gene id: 9925:MPDZ
uniprot id: A0A452FNV2
names: Subcellular Location Annotation
messages: Cell membrane
messages: tight junction

9925:OLFM1
gene id: 9925:OLFM1
uniprot id: A0A452E8C9
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9925:PGLYRP2
gene id: 9925:PGLYRP2
uniprot id: A0A452F0C6
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9925:SLC22A8
gene id: 9925:SLC22A8
uniprot id: A0A452EP37
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9925:SERF2
gene id: 9925:SERF2
uniprot id: A5JSS4
names: Function
names: Similarity
messages: Belongs to the SERF family.
messages: Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (By similarity).

9925:CCT5
gene id: 9925:CCT5
uniprot id: A0A452F3U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9925:GHITM
gene id: 9925:GHITM
uniprot id: A9LLG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9925:LZIC
gene id: 9925:LZIC
uniprot id: A0A452F0R1
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9925:OTUB2
gene id: 9925:OTUB2
uniprot id: A0A452FF73
names: Similarity
messages: Belongs to the peptidase C65 family.

9925:SERINC4
gene id: 9925:SERINC4
uniprot id: A0A452FGB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9925:BUD31
gene id: 9925:BUD31
uniprot id: A0A452EQF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9925:AIPL1
gene id: 9925:AIPL1
uniprot id: A0A452EBM6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be important in protein trafficking and/or protein folding and stabilization.
messages: Nucleus

9925:KCTD20
gene id: 9925:KCTD20
uniprot id: A0A452FPV8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:MEP1B
gene id: 9925:MEP1B
uniprot id: A0A452DL84
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:AIG1
gene id: 9925:AIG1
uniprot id: A0A452EBD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9925:VIMP
gene id: 9925:VIMP
uniprot id: A0A452FTU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
messages: Membrane

9925:INTS3
gene id: 9925:INTS3
uniprot id: A0A452G4J0
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9925:LTB4R2
gene id: 9925:LTB4R2
uniprot id: A0A452DSX5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:LOC102181567
gene id: 9925:LOC102181567
uniprot id: A0A452F8Q8
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:ARF5
gene id: 9925:ARF5
uniprot id: A0A452F738
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:SEC62
gene id: 9925:SEC62
uniprot id: A0A452FEP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:PCYT1A
gene id: 9925:PCYT1A
uniprot id: A0A8C2N692
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9925:DCAF11
gene id: 9925:DCAF11
uniprot id: A0A452EWY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9925:ACVR1B
gene id: 9925:ACVR1B
uniprot id: A0A452F5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:HOXC5
gene id: 9925:HOXC5
uniprot id: A0A452DSG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:ZBED9
gene id: 9925:ZBED9
uniprot id: A0A452ENK9
names: Subcellular Location Annotation
messages: Nucleus

9925:UCK1
gene id: 9925:UCK1
uniprot id: A0A452E6I6
names: Similarity
messages: Belongs to the uridine kinase family.

9925:PLXNA2
gene id: 9925:PLXNA2
uniprot id: A0A452F7F2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:SLC20A1
gene id: 9925:SLC20A1
uniprot id: A0A452F8J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

9925:B3GNT3
gene id: 9925:B3GNT3
uniprot id: A0A452G4Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:SNX18
gene id: 9925:SNX18
uniprot id: A0A452FH19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9925:EDNRB
gene id: 9925:EDNRB
uniprot id: A0A452E880
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:FLT1
gene id: 9925:FLT1
uniprot id: A0A452FA74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9925:HBP1
gene id: 9925:HBP1
uniprot id: A0A452FXT6
uniprot id: A0A8C2NS51
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9925:EIF4EBP1
gene id: 9925:EIF4EBP1
uniprot id: G1JSG2
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9925:CNR1
gene id: 9925:CNR1
uniprot id: A0A452DV57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.
messages: Interacts (via C-terminus) with CNRIP1.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

9925:TMEM86A
gene id: 9925:TMEM86A
uniprot id: A0A452FEW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9925:LOC100861326
gene id: 9925:LOC100861326
uniprot id: A0A452DXN0
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9925:LOC102181752
gene id: 9925:LOC102181752
uniprot id: A0A8C2NCV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.
messages: Secreted

9925:GLRA3
gene id: 9925:GLRA3
uniprot id: A0A452E8R0
uniprot id: A0A452E8S5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9925:CXCL9
gene id: 9925:CXCL9
uniprot id: A0A452FIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9925:GPR87
gene id: 9925:GPR87
uniprot id: A0A452G8D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:RRP15
gene id: 9925:RRP15
uniprot id: A0A452EHW8
names: Similarity
messages: Belongs to the RRP15 family.

9925:LOC102177976
gene id: 9925:LOC102177976
uniprot id: A0A452DWD7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:MEGF8
gene id: 9925:MEGF8
uniprot id: A0A452ENX2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:SLF2
gene id: 9925:SLF2
uniprot id: A0A452FGI2
names: Similarity
messages: Belongs to the FAM178 family.

9925:PLSCR3
gene id: 9925:PLSCR3
uniprot id: A0A8C2Y3W9
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9925:RAB3D
gene id: 9925:RAB3D
uniprot id: A0A452EMT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9925:THOC5
gene id: 9925:THOC5
uniprot id: A0A452G815
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9925:CADM2
gene id: 9925:CADM2
uniprot id: A0A452FWQ7
names: Similarity
messages: Belongs to the nectin family.

9925:MAPT
gene id: 9925:MAPT
uniprot id: A0A452G6R7
uniprot id: A0A452G6X8
uniprot id: O02828
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in neurons.
messages: Interacts with MARK1, MARK2, MARK3 and MARK4 (By similarity). Interacts with SQSTM1 when polyubiquitinated (By similarity). Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with FKBP4 (By similarity). Binds to CSNK1D (By similarity). Interacts with SGK1 (By similarity). Interacts with PIN1 (By similarity). Interacts with LRRK2 (By similarity). Interacts with LRP1, leading to endocytosis; this interaction is reduced in the presence of LRPAP1/RAP (By similarity).
messages: Membrane
messages: Phosphorylation at various serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1, CDK1, CDK5, GSK3, MAPK) (a few sites per protein in interphase, more in mitosis), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1, MARK2, MARK3, MARK4), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation at Ser-224 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated by PHK. Dephosphorylation at several serine and threonine residues by the serine/threonine phosphatase PPP5C (By similarity).
messages: Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By similarity).
messages: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
messages: The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.
messages: axon
messages: cytoskeleton
messages: cytosol
messages: dendrite

9925:LOC102172658
gene id: 9925:LOC102172658
uniprot id: A0A452DP30
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:TMEM33
gene id: 9925:TMEM33
uniprot id: A0A452G7T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9925:BLMH
gene id: 9925:BLMH
uniprot id: A0A452DWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9925:TNFSF11
gene id: 9925:TNFSF11
uniprot id: A0A452ENF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9925:DSG1
gene id: 9925:DSG1
uniprot id: A0A452FC03
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9925:LOC108633800
gene id: 9925:LOC108633800
uniprot id: A0A452DMI4
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9925:CMPK1
gene id: 9925:CMPK1
uniprot id: I6U6S0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9925:PAPSS1
gene id: 9925:PAPSS1
uniprot id: A0A452DV72
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9925:SFT2D3
gene id: 9925:SFT2D3
uniprot id: A0A452E0A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9925:CDH5
gene id: 9925:CDH5
uniprot id: A0A452EQV9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Membrane

9925:MTHFR
gene id: 9925:MTHFR
uniprot id: A0A452G4N1
uniprot id: A0A8C2RSE5
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

9925:PISD
gene id: 9925:PISD
uniprot id: A0A452FEW7
uniprot id: A0A452FFM8
uniprot id: A0A8C2RR77
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9925:ACSL1
gene id: 9925:ACSL1
uniprot id: A0A452FP97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9925:ATP1A1
gene id: 9925:ATP1A1
uniprot id: A0A452F0I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9925:PRPF19
gene id: 9925:PRPF19
uniprot id: A0A452F4Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9925:NIPA2
gene id: 9925:NIPA2
uniprot id: A0A452G0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9925:FOS
gene id: 9925:FOS
uniprot id: A0A452G2J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Fos subfamily.
messages: cytosol

9925:ABCG4
gene id: 9925:ABCG4
uniprot id: A0A8C2R3J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9925:LOC100861175
gene id: 9925:LOC100861175
uniprot id: Q6R646
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9925:NAV3
gene id: 9925:NAV3
uniprot id: A0A452EBE9
uniprot id: A0A452EBV3
uniprot id: A0A452EBZ5
uniprot id: A0A452EC65
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9925:ENTPD5
gene id: 9925:ENTPD5
uniprot id: A0A452G9I2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9925:SLC16A4
gene id: 9925:SLC16A4
uniprot id: A0A452G185
names: Subcellular Location Annotation
messages: Membrane

9925:IVD
gene id: 9925:IVD
uniprot id: A0A8C2SI76
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9925:CCNL1
gene id: 9925:CCNL1
uniprot id: A0A452ERE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

9925:ADGRG7
gene id: 9925:ADGRG7
uniprot id: A0A452EVX7
names: Subcellular Location Annotation
messages: Membrane

9925:SNURF
gene id: 9925:SNURF
uniprot id: A0A452DMB9
names: Similarity
messages: Belongs to the SNURF family.

9925:OSBPL2
gene id: 9925:OSBPL2
uniprot id: A0A452FL01
names: Similarity
messages: Belongs to the OSBP family.

9925:MRPS16
gene id: 9925:MRPS16
uniprot id: A0A452DKB0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9925:DGKD
gene id: 9925:DGKD
uniprot id: A0A452G409
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9925:LOC102190120
gene id: 9925:LOC102190120
uniprot id: A0A452DWW5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NDUFAB1
gene id: 9925:NDUFAB1
uniprot id: A0A452E7C6
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9925:FAM26E
gene id: 9925:FAM26E
uniprot id: A0A452F625
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9925:SAMM50
gene id: 9925:SAMM50
uniprot id: A0A452FVK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9925:LOC102176434
gene id: 9925:LOC102176434
uniprot id: A0A452DXI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102181867
gene id: 9925:LOC102181867
uniprot id: A0A452E3N9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Monomer.
messages: Secreted

9925:PPARGC1B
gene id: 9925:PPARGC1B
uniprot id: A0A452DQD6
names: Subcellular Location Annotation
messages: Nucleus

9925:NOTCH3
gene id: 9925:NOTCH3
uniprot id: A0A452EYH5
uniprot id: A0A452EYW6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9925:CAPN10
gene id: 9925:CAPN10
uniprot id: A0A452EWS5
names: Similarity
messages: Belongs to the peptidase C2 family.

9925:HSD17B2
gene id: 9925:HSD17B2
uniprot id: A0A452DN30
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:FSCN3
gene id: 9925:FSCN3
uniprot id: A0A452EAN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9925:LOC102189976
gene id: 9925:LOC102189976
uniprot id: A0A452E618
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RAP1GDS1
gene id: 9925:RAP1GDS1
uniprot id: A0A452EG31
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: cytosol

9925:PNPO
gene id: 9925:PNPO
uniprot id: A0A452DR09
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

9925:C13H20orf27
gene id: 9925:C13H20orf27
uniprot id: A0A452EFI4
names: Similarity
messages: Belongs to the UPF0687 family.

9925:ITPK1
gene id: 9925:ITPK1
uniprot id: A0A452EZG1
names: Similarity
messages: Belongs to the ITPK1 family.

9925:MC3R
gene id: 9925:MC3R
uniprot id: A0A0N7BCA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9925:BACE1
gene id: 9925:BACE1
uniprot id: A0A452F468
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: trans-Golgi network

9925:UBALD2
gene id: 9925:UBALD2
uniprot id: A0A452FHQ2
names: Similarity
messages: Belongs to the UBALD family.

9925:C4H7orf25
gene id: 9925:C4H7orf25
uniprot id: A0A452DZ48
names: Similarity
messages: Belongs to the UPF0415 family.

9925:LARS
gene id: 9925:LARS
uniprot id: A0A452ENN3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:TLCD2
gene id: 9925:TLCD2
uniprot id: A0A8C2XYX0
names: Subcellular Location Annotation
messages: Membrane

9925:HYAL2
gene id: 9925:HYAL2
uniprot id: A0A452DVX5
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9925:AGPAT3
gene id: 9925:AGPAT3
uniprot id: A0A452F818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9925:LOC102178923
gene id: 9925:LOC102178923
uniprot id: A0A452E6I9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ST14
gene id: 9925:ST14
uniprot id: A0A452G8K5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Degrades extracellular matrix.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:NIPAL3
gene id: 9925:NIPAL3
uniprot id: A0A452FH17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9925:CRY1
gene id: 9925:CRY1
uniprot id: A0A452GAD2
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9925:RGS14
gene id: 9925:RGS14
uniprot id: A0A452DPD3
names: Subcellular Location Annotation
messages: dendrite

9925:CSNK2A2
gene id: 9925:CSNK2A2
uniprot id: A0A452FFM4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:MDH1
gene id: 9925:MDH1
uniprot id: A0A452EQW7
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9925:TMCC1
gene id: 9925:TMCC1
uniprot id: A0A452EWZ1
names: Similarity
messages: Belongs to the TEX28 family.

9925:RPL13A
gene id: 9925:RPL13A
uniprot id: A0A452FKH3
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9925:APCS
gene id: 9925:APCS
uniprot id: A0A452G8G4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9925:PTCD3
gene id: 9925:PTCD3
uniprot id: A0A452EAC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9925:GLMP
gene id: 9925:GLMP
uniprot id: A0A452F4D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9925:CTSC
gene id: 9925:CTSC
uniprot id: A0A452EJ14
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9925:LOC102191624
gene id: 9925:LOC102191624
uniprot id: A0A452DZ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9925:RASSF5
gene id: 9925:RASSF5
uniprot id: A0A452FDK5
names: Subcellular Location Annotation
messages: cytoskeleton

9925:INPPL1
gene id: 9925:INPPL1
uniprot id: A0A452ENQ7
names: Similarity
names: Subcellular Location Annotation
messages: Basal cell membrane
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane
messages: Nucleus speckle
messages: filopodium
messages: lamellipodium
messages: spindle pole

9925:BCL9L
gene id: 9925:BCL9L
uniprot id: A0A452DQM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9925:EFEMP2
gene id: 9925:EFEMP2
uniprot id: A0A452EXQ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:GPX8
gene id: 9925:GPX8
uniprot id: A0A452FPY4
uniprot id: A0A8C2PIV6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9925:LOC102170447
gene id: 9925:LOC102170447
uniprot id: A0A452DS51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FBXO32
gene id: 9925:FBXO32
uniprot id: A0A452ER17
names: Subcellular Location Annotation
messages: Nucleus

9925:TMEM120A
gene id: 9925:TMEM120A
uniprot id: A0A452FS78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9925:TMEM17
gene id: 9925:TMEM17
uniprot id: A0A452ECZ9
names: Subcellular Location Annotation
messages: Membrane

9925:KAT8
gene id: 9925:KAT8
uniprot id: A0A452F581
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9925:LOC102171944
gene id: 9925:LOC102171944
uniprot id: A0A452DS67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:BDKRB1
gene id: 9925:BDKRB1
uniprot id: A0A452DNN3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9925:GGACT
gene id: 9925:GGACT
uniprot id: A0A452FEN9
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9925:ARHGEF1
gene id: 9925:ARHGEF1
uniprot id: A0A452FMS3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9925:NAGLU
gene id: 9925:NAGLU
uniprot id: A0A452G3T7
names: Subcellular Location Annotation
messages: Lysosome

9925:SULF2
gene id: 9925:SULF2
uniprot id: A0A452EL36
uniprot id: A0A452ELB6
uniprot id: A0A452ELQ0
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9925:TAS2R7
gene id: 9925:TAS2R7
uniprot id: A0A452DWC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Membrane

9925:BTG3
gene id: 9925:BTG3
uniprot id: A0A023IYG5
names: Similarity
messages: Belongs to the BTG family.

9925:LOC102177552
gene id: 9925:LOC102177552
uniprot id: A0A452ELR9
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9925:TBX4
gene id: 9925:TBX4
uniprot id: A0A452FF81
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:AGRN
gene id: 9925:AGRN
uniprot id: A0A452DTQ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:EIF3B
gene id: 9925:EIF3B
uniprot id: A0A452E278
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2. Interacts with METTL3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: The RRM domain mediates interaction with EIF3J.

9925:PFKM
gene id: 9925:PFKM
uniprot id: A0A452G4K3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CLNS1A
gene id: 9925:CLNS1A
uniprot id: A0A452FNF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9925:CPA3
gene id: 9925:CPA3
uniprot id: A0A452E704
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:MAP6
gene id: 9925:MAP6
uniprot id: A0A452FUV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

9925:LOC108633425
gene id: 9925:LOC108633425
uniprot id: A0A452DPN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DDC
gene id: 9925:DDC
uniprot id: A0A452EHQ2
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9925:MRPL51
gene id: 9925:MRPL51
uniprot id: A0A452E827
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

9925:FAM193B
gene id: 9925:FAM193B
uniprot id: A0A452FX81
uniprot id: A0A452FXX9
names: Similarity
messages: Belongs to the FAM193 family.

9925:GNB4
gene id: 9925:GNB4
uniprot id: A0A452E6C1
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9925:APH1A
gene id: 9925:APH1A
uniprot id: A0A452EQZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9925:LOC100860930
gene id: 9925:LOC100860930
uniprot id: Q7YRW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KRTAP type 6 family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9925:LOC102170238
gene id: 9925:LOC102170238
uniprot id: A0A452DRT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9925:COPB2
gene id: 9925:COPB2
uniprot id: A0A452FMD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

9925:ABI2
gene id: 9925:ABI2
uniprot id: A0A452DNK9
uniprot id: A0A452DNL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9925:MPI
gene id: 9925:MPI
uniprot id: A0A452EA58
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9925:TXN
gene id: 9925:TXN
uniprot id: A0A452EGP3
names: Similarity
messages: Belongs to the thioredoxin family.

9925:RELT
gene id: 9925:RELT
uniprot id: A0A8C2NVZ8
names: Similarity
messages: Belongs to the RELT family.

9925:CCDC126
gene id: 9925:CCDC126
uniprot id: A0A452FX04
names: Subcellular Location Annotation
messages: Secreted

9925:LOC106503958
gene id: 9925:LOC106503958
uniprot id: A0A452E0F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9925:AMACR
gene id: 9925:AMACR
uniprot id: A0A452E8V4
names: Similarity
messages: Belongs to the CoA-transferase III family.

9925:ZIC2
gene id: 9925:ZIC2
uniprot id: A0A452FVU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9925:NHP2
gene id: 9925:NHP2
uniprot id: A0A452EPY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9925:MSX1
gene id: 9925:MSX1
uniprot id: A0A452EK01
names: Subcellular Location Annotation
messages: Nucleus

9925:ACTL6B
gene id: 9925:ACTL6B
uniprot id: A0A452F0X5
names: Similarity
messages: Belongs to the actin family.

9925:ACTL7B
gene id: 9925:ACTL7B
uniprot id: A0A452DNZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9925:CUL7
gene id: 9925:CUL7
uniprot id: A0A452EP61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9925:BCL7C
gene id: 9925:BCL7C
uniprot id: A0A452EHJ2
uniprot id: A0A8C2SHW9
names: Similarity
messages: Belongs to the BCL7 family.

9925:NAPA
gene id: 9925:NAPA
uniprot id: A0A452FTQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9925:PEX10
gene id: 9925:PEX10
uniprot id: A0A452F8Y1
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9925:SLC5A1
gene id: 9925:SLC5A1
uniprot id: V9I0K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9925:METTL15
gene id: 9925:METTL15
uniprot id: A0A452F3G4
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9925:IL10
gene id: 9925:IL10
uniprot id: A0A452EY26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-10 family.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Immune regulatory cytokine.
messages: Secreted

9925:SLC12A2
gene id: 9925:SLC12A2
uniprot id: A0A452GAJ7
uniprot id: A0A452GAK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9925:NOL11
gene id: 9925:NOL11
uniprot id: A0A452G3N2
names: Subcellular Location Annotation
messages: nucleolus

9925:P2RX1
gene id: 9925:P2RX1
uniprot id: A0A452FUE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9925:LOC102179515
gene id: 9925:LOC102179515
uniprot id: A0A452F6J7
names: Similarity
messages: Belongs to the intermediate filament family.

9925:TAF1B
gene id: 9925:TAF1B
uniprot id: A0A452EIN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

9925:ANO10
gene id: 9925:ANO10
uniprot id: A0A452EB09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:MAGOHB
gene id: 9925:MAGOHB
uniprot id: A0A452GB69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9925:MS4A2
gene id: 9925:MS4A2
uniprot id: A0A452G4F1
names: Similarity
messages: Belongs to the MS4A family.

9925:TRIM2
gene id: 9925:TRIM2
uniprot id: A0A452FDC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9925:LOC108637838
gene id: 9925:LOC108637838
uniprot id: A0A452F071
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9925:ABR
gene id: 9925:ABR
uniprot id: A0A452FVU2
uniprot id: A0A452FVU7
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9925:OGFOD1
gene id: 9925:OGFOD1
uniprot id: A0A452EF90
names: Similarity
messages: Belongs to the TPA1 family.

9925:LOC102181383
gene id: 9925:LOC102181383
uniprot id: A0A452DW09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:FAM83C
gene id: 9925:FAM83C
uniprot id: A0A452FGH6
names: Similarity
messages: Belongs to the FAM83 family.

9925:NCAPH
gene id: 9925:NCAPH
uniprot id: A0A452FTW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

9925:CNOT1
gene id: 9925:CNOT1
uniprot id: A0A452E3Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9925:CNN2
gene id: 9925:CNN2
uniprot id: A0A452FS01
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9925:MMP13
gene id: 9925:MMP13
uniprot id: A0A452FGN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
messages: Secreted

9925:PRDM16
gene id: 9925:PRDM16
uniprot id: A0A452F167
names: Subcellular Location Annotation
messages: Nucleus

9925:IREB2
gene id: 9925:IREB2
uniprot id: A0A452FRW6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

9925:MAP2
gene id: 9925:MAP2
uniprot id: A0A452DLW2
uniprot id: A0A452DLW3
uniprot id: A0A8C2N6X7
names: Subcellular Location Annotation
messages: cytoskeleton

9925:CYB5A
gene id: 9925:CYB5A
uniprot id: A5HEW3
names: Similarity
messages: Belongs to the cytochrome b5 family.

9925:ZC3H12C
gene id: 9925:ZC3H12C
uniprot id: A0A452FH34
names: Similarity
messages: Belongs to the ZC3H12 family.

9925:GPBP1
gene id: 9925:GPBP1
uniprot id: A0A452E136
uniprot id: A0A452E146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9925:TNPO1
gene id: 9925:TNPO1
uniprot id: A0A452FTN8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:FAM134C
gene id: 9925:FAM134C
uniprot id: A0A452FI73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9925:UTP18
gene id: 9925:UTP18
uniprot id: A0A452E9K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

9925:FA2H
gene id: 9925:FA2H
uniprot id: A0A452EAY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:GRPEL2
gene id: 9925:GRPEL2
uniprot id: A0A452G916
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9925:BDNF
gene id: 9925:BDNF
uniprot id: A0A452DT84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
messages: Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
messages: Monomers and homodimers (By similarity). Binds to NTRK2/TRKB. Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (By similarity). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower affinity for the heterodimer formed by NGFR and SORCS2.
messages: Monomers and homodimers. Binds to NTRK2/TRKB.
messages: Secreted

9925:TCEB3
gene id: 9925:TCEB3
uniprot id: A0A452FFU6
names: Subcellular Location Annotation
messages: Nucleus

9925:ARRB2
gene id: 9925:ARRB2
uniprot id: A0A452ESP2
names: Similarity
messages: Belongs to the arrestin family.

9925:CSN1S2
gene id: 9925:CSN1S2
uniprot id: A0A6H0DUE2
uniprot id: P33049
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted
messages: The frequencies of the A, B and C alleles is estimated to be 0.85, 0.04 and 0.11 in the French dairy breeds 'Alpine' and 'Saanen'.

9925:HMGA2
gene id: 9925:HMGA2
uniprot id: Q76M67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9925:SMAD9
gene id: 9925:SMAD9
uniprot id: A0A452EZ11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9925:CCNH
gene id: 9925:CCNH
uniprot id: A0A452FV47
uniprot id: A0A452FVL1
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9925:NIM1K
gene id: 9925:NIM1K
uniprot id: A0A452F0A1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:CAPN15
gene id: 9925:CAPN15
uniprot id: A0A452FEC5
names: Similarity
messages: Belongs to the peptidase C2 family.

9925:RSBN1L
gene id: 9925:RSBN1L
uniprot id: A0A452DS50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9925:MYO1B
gene id: 9925:MYO1B
uniprot id: A0A452EGU0
uniprot id: A0A452EH70
uniprot id: A0A452EHI0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:NMD3
gene id: 9925:NMD3
uniprot id: A0A452ET23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9925:LOC102182470
gene id: 9925:LOC102182470
uniprot id: A0A452E328
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DYNLL2
gene id: 9925:DYNLL2
uniprot id: A0A452E1S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9925:NAT10
gene id: 9925:NAT10
uniprot id: A0A452G5V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9925:FBLN5
gene id: 9925:FBLN5
uniprot id: A0A452F0L6
uniprot id: A0A8C2PAP6
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC100861184
gene id: 9925:LOC100861184
uniprot id: Q6R637
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:TECR
gene id: 9925:TECR
uniprot id: A0A452FDQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:PSMD12
gene id: 9925:PSMD12
uniprot id: A0A452G300
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9925:POLR1E
gene id: 9925:POLR1E
uniprot id: A0A452F9T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9925:LOC102189488
gene id: 9925:LOC102189488
uniprot id: A0A452FYD6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.

9925:ST6GALNAC5
gene id: 9925:ST6GALNAC5
uniprot id: A0A452EW14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:HYI
gene id: 9925:HYI
uniprot id: A0A452E5Q7
uniprot id: A0A8C2R1H0
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

9925:MCUB
gene id: 9925:MCUB
uniprot id: A0A452EAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:ORC6
gene id: 9925:ORC6
uniprot id: A0A452FNJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9925:AKR1A1
gene id: 9925:AKR1A1
uniprot id: A0A452DRZ8
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9925:TMEM39A
gene id: 9925:TMEM39A
uniprot id: A0A452F5J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9925:RAG2
gene id: 9925:RAG2
uniprot id: A0A452DZ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9925:LOC102185066
gene id: 9925:LOC102185066
uniprot id: A0A452EB66
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:LOC108633303
gene id: 9925:LOC108633303
uniprot id: A0A452FGI7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

9925:CNNM4
gene id: 9925:CNNM4
uniprot id: A0A452EIC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9925:GPX7
gene id: 9925:GPX7
uniprot id: A0A452G0M7
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9925:LOC102186111
gene id: 9925:LOC102186111
uniprot id: A0A452ELS1
names: Similarity
messages: Belongs to the serpin family.

9925:PRKRA
gene id: 9925:PRKRA
uniprot id: A0A452EQR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRKRA family.
messages: perinuclear region

9925:SNX6
gene id: 9925:SNX6
uniprot id: A0A452F2R6
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9925:IL17F
gene id: 9925:IL17F
uniprot id: A0A452DWT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9925:PRDM13
gene id: 9925:PRDM13
uniprot id: A0A452DSP9
names: Subcellular Location Annotation
messages: Nucleus

9925:PLD5
gene id: 9925:PLD5
uniprot id: A0A452F1V1
names: Similarity
messages: Belongs to the phospholipase D family.

9925:LOC102189863
gene id: 9925:LOC102189863
uniprot id: A0A452DUX7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9925:ZC3H12A
gene id: 9925:ZC3H12A
uniprot id: A0A452FKQ9
names: Similarity
messages: Belongs to the ZC3H12 family.

9925:MTMR6
gene id: 9925:MTMR6
uniprot id: A0A452FVA9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9925:TFB2M
gene id: 9925:TFB2M
uniprot id: A0A452F0M8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

9925:CDK10
gene id: 9925:CDK10
uniprot id: A0A8C2XUC3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:COG4
gene id: 9925:COG4
uniprot id: A0A452F1K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9925:LOC108636431
gene id: 9925:LOC108636431
uniprot id: A0A452DW33
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:NUF2
gene id: 9925:NUF2
uniprot id: A0A452FJJ2
names: Similarity
messages: Belongs to the NUF2 family.

9925:SLC5A7
gene id: 9925:SLC5A7
uniprot id: A0A452FRC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9925:KIAA1429
gene id: 9925:KIAA1429
uniprot id: A0A452ET57
uniprot id: A0A452ET72
names: Similarity
messages: Belongs to the vir family.

9925:METRNL
gene id: 9925:METRNL
uniprot id: A0A452FD15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the meteorin family.
messages: Secreted

9925:HPX
gene id: 9925:HPX
uniprot id: A0A452DRK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

9925:RFC1
gene id: 9925:RFC1
uniprot id: A0A452FBS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

9925:TMEM200A
gene id: 9925:TMEM200A
uniprot id: A0A452EE63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9925:LFNG
gene id: 9925:LFNG
uniprot id: A0A452FRL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:DBNDD1
gene id: 9925:DBNDD1
uniprot id: A0A8C2RBE6
uniprot id: A0A8C2RBL2
names: Similarity
messages: Belongs to the dysbindin family.

9925:SPAG7
gene id: 9925:SPAG7
uniprot id: A0A452G542
names: Subcellular Location Annotation
messages: Nucleus

9925:HS2ST1
gene id: 9925:HS2ST1
uniprot id: A0A452G6X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9925:MRPL52
gene id: 9925:MRPL52
uniprot id: A0A452EJR2
uniprot id: A0A8C2PHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9925:EREG
gene id: 9925:EREG
uniprot id: A0A452DLR7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PVALB
gene id: 9925:PVALB
uniprot id: A0A452G043
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9925:TIMM50
gene id: 9925:TIMM50
uniprot id: A0A452DPK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9925:WIF1
gene id: 9925:WIF1
uniprot id: A0A452EB31
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MYBL1
gene id: 9925:MYBL1
uniprot id: A0A8C2PB75
uniprot id: A0A8C2QWN4
names: Subcellular Location Annotation
messages: Nucleus

9925:TUBB2A
gene id: 9925:TUBB2A
uniprot id: A0A452G3J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9925:AACS
gene id: 9925:AACS
uniprot id: A0A452EWJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
messages: cytosol

9925:LOC102191519
gene id: 9925:LOC102191519
uniprot id: A0A452F606
uniprot id: A0A452F615
uniprot id: A0A452F619
uniprot id: A0A452F630
uniprot id: A0A452F635
uniprot id: A0A452F640
uniprot id: A0A452F6G5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9925:KPNA5
gene id: 9925:KPNA5
uniprot id: A0A452G264
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9925:POLR3F
gene id: 9925:POLR3F
uniprot id: A0A452EMI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9925:DPYS
gene id: 9925:DPYS
uniprot id: A0A452G247
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

9925:EPS8
gene id: 9925:EPS8
uniprot id: A0A452DUX9
uniprot id: A0A452DV71
names: Similarity
messages: Belongs to the EPS8 family.

9925:LOC102178483
gene id: 9925:LOC102178483
uniprot id: G8FGA4
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:COPS4
gene id: 9925:COPS4
uniprot id: A0A452EN27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9925:LOC102184589
gene id: 9925:LOC102184589
uniprot id: A0A452ESF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9925:MRPS31
gene id: 9925:MRPS31
uniprot id: A0A452ECC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9925:CD4
gene id: 9925:CD4
uniprot id: A0A452E3R1
names: Subcellular Location Annotation
messages: Cell membrane

9925:ZFPM1
gene id: 9925:ZFPM1
uniprot id: A0A452E2Z5
names: Subcellular Location Annotation
messages: Nucleus

9925:UNK
gene id: 9925:UNK
uniprot id: A0A452EQC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9925:ZBED4
gene id: 9925:ZBED4
uniprot id: A0A452DQY3
names: Subcellular Location Annotation
messages: Nucleus

9925:ACTR2
gene id: 9925:ACTR2
uniprot id: A0A452EL50
names: Similarity
messages: Belongs to the actin family.

9925:CDK7
gene id: 9925:CDK7
uniprot id: A0A452FVY6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9925:EBNA1BP2
gene id: 9925:EBNA1BP2
uniprot id: A0A452FMC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

9925:FAM131C
gene id: 9925:FAM131C
uniprot id: A0A452ELN4
names: Similarity
messages: Belongs to the FAM131 family.

9925:LPGAT1
gene id: 9925:LPGAT1
uniprot id: A0A452F5J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9925:PHACTR4
gene id: 9925:PHACTR4
uniprot id: A0A452EYY9
uniprot id: A0A452EZ22
uniprot id: A0A452EZ68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

9925:HGD
gene id: 9925:HGD
uniprot id: A0A452G882
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9925:LOC102177333
gene id: 9925:LOC102177333
uniprot id: A0A452EZM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:DVL2
gene id: 9925:DVL2
uniprot id: A0A452G429
names: Similarity
messages: Belongs to the DSH family.

9925:C3H1orf123
gene id: 9925:C3H1orf123
uniprot id: A0A8C2NRE8
names: Similarity
messages: Belongs to the UPF0587 family.

9925:SQLE
gene id: 9925:SQLE
uniprot id: A0A452G1Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9925:RAX2
gene id: 9925:RAX2
uniprot id: A0A452FFP1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CRX.
messages: May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter.
messages: Nucleus

9925:UBE2D1
gene id: 9925:UBE2D1
uniprot id: A0A452F0F4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:NUP93
gene id: 9925:NUP93
uniprot id: A0A452FKT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus envelope
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9925:ATG5
gene id: 9925:ATG5
uniprot id: A0A452FAH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9925:WNT3A
gene id: 9925:WNT3A
uniprot id: A0A452EUC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:PTHLH
gene id: 9925:PTHLH
uniprot id: E2EAI4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9925:LOC102185483
gene id: 9925:LOC102185483
uniprot id: A0A452DVH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:JUN
gene id: 9925:JUN
uniprot id: A0A452DQ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9925:FAM212A
gene id: 9925:FAM212A
uniprot id: A0A452EJD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9925:TSEN2
gene id: 9925:TSEN2
uniprot id: A0A452EID7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9925:AFAP1L1
gene id: 9925:AFAP1L1
uniprot id: A0A452DQH0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in podosome and invadosome formation.
messages: invadopodium
messages: podosome

9925:LOC108638292
gene id: 9925:LOC108638292
uniprot id: A0A452E4X2
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:SOX10
gene id: 9925:SOX10
uniprot id: A0A452FCN7
names: Subcellular Location Annotation
messages: Nucleus

9925:DUSP16
gene id: 9925:DUSP16
uniprot id: A0A452E8T1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9925:ADGRF2
gene id: 9925:ADGRF2
uniprot id: A0A452FF09
uniprot id: A0A452FFF0
names: Subcellular Location Annotation
messages: Membrane

9925:CLCN2
gene id: 9925:CLCN2
uniprot id: A0A452EBV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

9925:SH3RF3
gene id: 9925:SH3RF3
uniprot id: A0A452ETB1
names: Similarity
messages: Belongs to the SH3RF family.

9925:FOXF2
gene id: 9925:FOXF2
uniprot id: A0A452FDA0
names: Subcellular Location Annotation
messages: Nucleus

9925:PLAC8
gene id: 9925:PLAC8
uniprot id: A0A452FM20
names: Similarity
messages: Belongs to the cornifelin family.

9925:PEX3
gene id: 9925:PEX3
uniprot id: A0A452G751
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9925:DCTN2
gene id: 9925:DCTN2
uniprot id: A0A452FJ27
uniprot id: A0A8C2S6D2
names: Function
names: Similarity
messages: Belongs to the dynactin subunit 2 family.
messages: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

9925:FNIP1
gene id: 9925:FNIP1
uniprot id: A0A452FGE6
uniprot id: A0A452FGP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9925:MED4
gene id: 9925:MED4
uniprot id: A0A452F129
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:KIT
gene id: 9925:KIT
uniprot id: A0A452FN97
uniprot id: Q28317
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3CD. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
messages: Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.
messages: Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Activity is down-regulated by PRKCA-mediated phosphorylation on serine residues (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).
messages: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation.

9925:EXOC6
gene id: 9925:EXOC6
uniprot id: A0A452E8Y3
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9925:KDM3B
gene id: 9925:KDM3B
uniprot id: A0A452G3P0
names: Subcellular Location Annotation
messages: Nucleus

9925:CHRM1
gene id: 9925:CHRM1
uniprot id: A0A452ECH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9925:SDHAF2
gene id: 9925:SDHAF2
uniprot id: A0A452FSY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9925:HAO2
gene id: 9925:HAO2
uniprot id: A0A452G7R2
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9925:ST6GAL1
gene id: 9925:ST6GAL1
uniprot id: A0A452EGM7
uniprot id: E9NST4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:DYNLRB1
gene id: 9925:DYNLRB1
uniprot id: A0A8C2RAJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9925:TYRO3
gene id: 9925:TYRO3
uniprot id: A0A452EKI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

9925:LOC108638246
gene id: 9925:LOC108638246
uniprot id: A0A452DQ36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:SLC19A3
gene id: 9925:SLC19A3
uniprot id: A0A452EUE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

9925:LOC102169103
gene id: 9925:LOC102169103
uniprot id: A0A8C2S9L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GSK3A
gene id: 9925:GSK3A
uniprot id: A0A452GAY2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9925:NBR1
gene id: 9925:NBR1
uniprot id: A0A452FT88
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9925:GRK7
gene id: 9925:GRK7
uniprot id: A0A452EAU4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9925:TAX1BP3
gene id: 9925:TAX1BP3
uniprot id: A0A452ED96
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9925:LOC102177429
gene id: 9925:LOC102177429
uniprot id: A0A8C2R433
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FAM167B
gene id: 9925:FAM167B
uniprot id: A0A452FY27
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9925:NEU3
gene id: 9925:NEU3
uniprot id: A0A452G1F1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9925:TP53
gene id: 9925:TP53
uniprot id: A0A452G0A3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9925:DOCK1
gene id: 9925:DOCK1
uniprot id: A0A452FAD9
names: Similarity
messages: Belongs to the DOCK family.

9925:MPV17L
gene id: 9925:MPV17L
uniprot id: A0A452FQY5
uniprot id: A0A8C2S6D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9925:SYNGR2
gene id: 9925:SYNGR2
uniprot id: A0A452DWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9925:NOL12
gene id: 9925:NOL12
uniprot id: A0A452FK12
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

9925:DHRS11
gene id: 9925:DHRS11
uniprot id: A0A452EN76
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:BMP5
gene id: 9925:BMP5
uniprot id: A0A452E3P9
names: Similarity
messages: Belongs to the TGF-beta family.

9925:ARSA
gene id: 9925:ARSA
uniprot id: A0A452EHN0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9925:UBE2T
gene id: 9925:UBE2T
uniprot id: A0A452ECX1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:LHX4
gene id: 9925:LHX4
uniprot id: A0A452EXX8
names: Subcellular Location Annotation
messages: Nucleus

9925:ABCD3
gene id: 9925:ABCD3
uniprot id: A0A452FTM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9925:LOC106503663
gene id: 9925:LOC106503663
uniprot id: A0A059TZ03
uniprot id: A0A452ELJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9925:BGLAP
gene id: 9925:BGLAP
uniprot id: A0A8C2NFR8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9925:MRM2
gene id: 9925:MRM2
uniprot id: A0A8C2PJ91
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

9925:YIPF3
gene id: 9925:YIPF3
uniprot id: A0A452EDL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

9925:TOB1
gene id: 9925:TOB1
uniprot id: A0A452DQ17
names: Similarity
messages: Belongs to the BTG family.

9925:SCG5
gene id: 9925:SCG5
uniprot id: A0A452ESI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9925:LOC108636981
gene id: 9925:LOC108636981
uniprot id: A0A452DXM6
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9925:PHF1
gene id: 9925:PHF1
uniprot id: A0A452FRK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9925:VANGL1
gene id: 9925:VANGL1
uniprot id: A0A452E8P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9925:PALMD
gene id: 9925:PALMD
uniprot id: A0A452G5M5
names: Similarity
messages: Belongs to the paralemmin family.

9925:TTYH3
gene id: 9925:TTYH3
uniprot id: A0A452E1Q3
uniprot id: A0A452E1Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9925:HEATR5B
gene id: 9925:HEATR5B
uniprot id: A0A452G0F3
names: Similarity
messages: Belongs to the HEATR5 family.

9925:IFIH1
gene id: 9925:IFIH1
uniprot id: A0A452FBA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9925:PTGS2
gene id: 9925:PTGS2
uniprot id: A0A452FSP2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane
messages: Nucleus inner membrane
messages: Nucleus outer membrane

9925:PTH1R
gene id: 9925:PTH1R
uniprot id: A0A452DV82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9925:ING5
gene id: 9925:ING5
uniprot id: A0A452EFF7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9925:LRRFIP2
gene id: 9925:LRRFIP2
uniprot id: A0A452FHL9
uniprot id: A0A452FHW3
uniprot id: A0A452FI03
uniprot id: A0A8C2P951
names: Similarity
messages: Belongs to the LRRFIP family.

9925:SPG21
gene id: 9925:SPG21
uniprot id: A0A452DWB8
names: Function
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9925:TMBIM6
gene id: 9925:TMBIM6
uniprot id: A0A452DMG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9925:HOOK1
gene id: 9925:HOOK1
uniprot id: A0A452G1J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9925:FASLG
gene id: 9925:FASLG
uniprot id: X2KPF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9925:LOC102181826
gene id: 9925:LOC102181826
uniprot id: A0A452FJL2
names: Similarity
messages: Belongs to the serpin family.

9925:GSTCD
gene id: 9925:GSTCD
uniprot id: A0A452F3H9
names: Similarity
messages: Belongs to the GSTCD family.

9925:HOXA9
gene id: 9925:HOXA9
uniprot id: A0A8C2NCR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9925:SLC39A11
gene id: 9925:SLC39A11
uniprot id: A0A452FRK2
uniprot id: A0A452FRQ3
names: Subcellular Location Annotation
messages: Membrane

9925:DNTTIP1
gene id: 9925:DNTTIP1
uniprot id: A0A452FS87
names: Subcellular Location Annotation
messages: Nucleus

9925:CSNK2B
gene id: 9925:CSNK2B
uniprot id: A0A452EHL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9925:CTSK
gene id: 9925:CTSK
uniprot id: A0A452E8V0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Cell membrane
messages: Lysosome
messages: Secreted

9925:CDC5L
gene id: 9925:CDC5L
uniprot id: A0A452FME0
names: Similarity
messages: Belongs to the CEF1 family.

9925:MVB12B
gene id: 9925:MVB12B
uniprot id: A0A452EGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9925:FAM3C
gene id: 9925:FAM3C
uniprot id: A0A452G8V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9925:ADGRL2
gene id: 9925:ADGRL2
uniprot id: A0A452F6J1
uniprot id: A0A452F736
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102184693
gene id: 9925:LOC102184693
uniprot id: A0A452G6N9
names: Similarity
messages: Belongs to the intermediate filament family.

9925:ATG13
gene id: 9925:ATG13
uniprot id: A0A452ELX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9925:SLCO4A1
gene id: 9925:SLCO4A1
uniprot id: A0A452FDL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9925:LOC102173207
gene id: 9925:LOC102173207
uniprot id: A0A452G190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9925:LOC102172465
gene id: 9925:LOC102172465
uniprot id: A0A452F0E7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:FOXE3
gene id: 9925:FOXE3
uniprot id: A0A452DR67
names: Subcellular Location Annotation
messages: Nucleus

9925:EBF4
gene id: 9925:EBF4
uniprot id: A0A452E5H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9925:CKMT2
gene id: 9925:CKMT2
uniprot id: A0A452F654
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9925:UBXN1
gene id: 9925:UBXN1
uniprot id: A0A452DTL6
names: Subcellular Location Annotation
messages: Cytoplasm

9925:ITGA8
gene id: 9925:ITGA8
uniprot id: A0A452F155
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:CCDC85B
gene id: 9925:CCDC85B
uniprot id: A0A452DMT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9925:DKK1
gene id: 9925:DKK1
uniprot id: A0A452EMK4
names: Similarity
messages: Belongs to the dickkopf family.

9925:LOC102178290
gene id: 9925:LOC102178290
uniprot id: A0A452E5Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MYO3A
gene id: 9925:MYO3A
uniprot id: A0A452ESN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

9925:GNG4
gene id: 9925:GNG4
uniprot id: A0A452DL78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:NNT
gene id: 9925:NNT
uniprot id: A0A452FLH3
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9925:STX4
gene id: 9925:STX4
uniprot id: A0A452EI11
names: Similarity
messages: Belongs to the syntaxin family.

9925:BMP6
gene id: 9925:BMP6
uniprot id: A0A452G7Z3
names: Similarity
messages: Belongs to the TGF-beta family.

9925:NPB
gene id: 9925:NPB
uniprot id: A0A452FHJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

9925:LIF
gene id: 9925:LIF
uniprot id: A0A452EKJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

9925:MTMR3
gene id: 9925:MTMR3
uniprot id: A0A452EVB1
uniprot id: A0A452EVF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9925:WDFY2
gene id: 9925:WDFY2
uniprot id: A0A452FPH4
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9925:HNRNPU
gene id: 9925:HNRNPU
uniprot id: A0A452DR33
names: Subcellular Location Annotation
messages: Nucleus

9925:ABAT
gene id: 9925:ABAT
uniprot id: A0A452FMV0
uniprot id: A0A8C2R213
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9925:KNG1
gene id: 9925:KNG1
uniprot id: A0A452E819
names: Subcellular Location Annotation
messages: extracellular space

9925:EPHA4
gene id: 9925:EPHA4
uniprot id: A0A452G0A9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9925:EPHA2
gene id: 9925:EPHA2
uniprot id: A0A452ERX4
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102182376
gene id: 9925:LOC102182376
uniprot id: A0A452DRW3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:PRDM4
gene id: 9925:PRDM4
uniprot id: A0A452F9I6
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

9925:ACKR4
gene id: 9925:ACKR4
uniprot id: A0A452DVY4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:SMC2
gene id: 9925:SMC2
uniprot id: A0A452DRD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

9925:AMDHD2
gene id: 9925:AMDHD2
uniprot id: A0A452ELC6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.
messages: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.

9925:CCND3
gene id: 9925:CCND3
uniprot id: A0A452GA73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9925:ARPC5
gene id: 9925:ARPC5
uniprot id: A0A452EYY1
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9925:IER3IP1
gene id: 9925:IER3IP1
uniprot id: A0A452FE54
names: Similarity
messages: Belongs to the YOS1 family.

9925:KRT27
gene id: 9925:KRT27
uniprot id: Q6R649
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).
messages: Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity).
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

9925:CPT1C
gene id: 9925:CPT1C
uniprot id: A0A8C2RVY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:CCR7
gene id: 9925:CCR7
uniprot id: A0A8C2PE33
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:MAPK13
gene id: 9925:MAPK13
uniprot id: A0A452FU55
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

9925:GALNS
gene id: 9925:GALNS
uniprot id: A0A452EL24
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Homodimer.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9925:ABO
gene id: 9925:ABO
uniprot id: A0A8C2SDQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9925:TAF8
gene id: 9925:TAF8
uniprot id: A0A452F3Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9925:CD38
gene id: 9925:CD38
uniprot id: A0A452DQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Membrane

9925:VAMP8
gene id: 9925:VAMP8
uniprot id: A0A8C2P7Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9925:PPP2R2B
gene id: 9925:PPP2R2B
uniprot id: A0A452ENE8
uniprot id: A0A452ENH0
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9925:LAMP3
gene id: 9925:LAMP3
uniprot id: A0A452EAF9
uniprot id: A0A452EAX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9925:PSD4
gene id: 9925:PSD4
uniprot id: A0A452G149
names: Subcellular Location Annotation
messages: ruffle membrane

9925:LSR
gene id: 9925:LSR
uniprot id: A0A452ESE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9925:ARG1
gene id: 9925:ARG1
uniprot id: C6K4R6
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9925:LOC102190621
gene id: 9925:LOC102190621
uniprot id: A0A452ENP1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:LOC102179574
gene id: 9925:LOC102179574
uniprot id: A0A452F9J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9925:NKIRAS1
gene id: 9925:NKIRAS1
uniprot id: A0A452EBA7
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9925:GPAT4
gene id: 9925:GPAT4
uniprot id: A0A452FGV6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9925:C19H17orf105
gene id: 9925:C19H17orf105
uniprot id: A0A452F3T6
names: Similarity
messages: Belongs to the CFAP97 family.

9925:GIPC2
gene id: 9925:GIPC2
uniprot id: A0A452FT54
names: Similarity
messages: Belongs to the GIPC family.

9925:VPS72
gene id: 9925:VPS72
uniprot id: A0A452EME9
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9925:RTN1
gene id: 9925:RTN1
uniprot id: A0A452EV33
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:GJA1
gene id: 9925:GJA1
uniprot id: A0A452DQ32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:ESF1
gene id: 9925:ESF1
uniprot id: A0A452FHK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9925:EDC3
gene id: 9925:EDC3
uniprot id: A0A452FU95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9925:LOC108638228
gene id: 9925:LOC108638228
uniprot id: A0A452DR57
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:HAUS1
gene id: 9925:HAUS1
uniprot id: A0A452GB93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9925:EEF1B2
gene id: 9925:EEF1B2
uniprot id: H9TKZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9925:FAM110D
gene id: 9925:FAM110D
uniprot id: A0A8C2N984
names: Similarity
messages: Belongs to the FAM110 family.

9925:CENPC
gene id: 9925:CENPC
uniprot id: A0A452ESK3
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

9925:TNKS2
gene id: 9925:TNKS2
uniprot id: A0A452FI27
names: Function
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9925:SNTG1
gene id: 9925:SNTG1
uniprot id: A0A452FSQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9925:RNPC3
gene id: 9925:RNPC3
uniprot id: A0A452FE90
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

9925:PTX3
gene id: 9925:PTX3
uniprot id: A0A452EC85
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102191741
gene id: 9925:LOC102191741
uniprot id: A0A452E219
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9925:HSPB1
gene id: 9925:HSPB1
uniprot id: A0A452ESU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9925:MED11
gene id: 9925:MED11
uniprot id: A0A8C2SBZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:ANXA2
gene id: 9925:ANXA2
uniprot id: A0A452DSB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
messages: Membrane
messages: basement membrane

9925:CLDN12
gene id: 9925:CLDN12
uniprot id: A0A452DM00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9925:RACK1
gene id: 9925:RACK1
uniprot id: A0A452ESG4
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

9925:AURKB
gene id: 9925:AURKB
uniprot id: A0A452FQM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centromere

9925:ZKSCAN4
gene id: 9925:ZKSCAN4
uniprot id: A0A452ECB6
names: Subcellular Location Annotation
messages: Nucleus

9925:MRPS5
gene id: 9925:MRPS5
uniprot id: A0A452FGN3
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9925:MUSTN1
gene id: 9925:MUSTN1
uniprot id: A0A8C2SM57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9925:NDUFS4
gene id: 9925:NDUFS4
uniprot id: A0A452G117
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9925:GNS
gene id: 9925:GNS
uniprot id: P50426
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Lysosome
messages: Processed by internal peptidase.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9925:CEP57
gene id: 9925:CEP57
uniprot id: A0A452EGW0
names: Similarity
messages: Belongs to the translokin family.

9925:PYGM
gene id: 9925:PYGM
uniprot id: A0A452E8N8
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9925:PRICKLE2
gene id: 9925:PRICKLE2
uniprot id: A0A452E4T0
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9925:FMO1
gene id: 9925:FMO1
uniprot id: A0A452E6M3
uniprot id: A0A452E6N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

9925:LOC102175005
gene id: 9925:LOC102175005
uniprot id: A0A452EAN2
names: Subcellular Location Annotation
messages: Membrane

9925:NPPA
gene id: 9925:NPPA
uniprot id: R4N479
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.
messages: May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9925:TLCD1
gene id: 9925:TLCD1
uniprot id: A0A452G4L2
names: Subcellular Location Annotation
messages: Membrane

9925:CD63
gene id: 9925:CD63
uniprot id: A0A452FHI7
uniprot id: A0A8C2N8C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9925:HPS3
gene id: 9925:HPS3
uniprot id: A0A452FPQ1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9925:AP1G2
gene id: 9925:AP1G2
uniprot id: A0A452FTZ7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9925:ADGRG3
gene id: 9925:ADGRG3
uniprot id: A0A452E5P8
names: Subcellular Location Annotation
messages: Membrane

9925:CHRNE
gene id: 9925:CHRNE
uniprot id: A0A8C2SAJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:LOC102189373
gene id: 9925:LOC102189373
uniprot id: A0A452FCP7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:TARS2
gene id: 9925:TARS2
uniprot id: A0A452F5U5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9925:RARB
gene id: 9925:RARB
uniprot id: A0A452E9H5
uniprot id: A0A452EA37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:AGTPBP1
gene id: 9925:AGTPBP1
uniprot id: A0A452ENM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9925:RCL1
gene id: 9925:RCL1
uniprot id: A0A452EC56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

9925:RBM48
gene id: 9925:RBM48
uniprot id: A0A452ENZ6
names: Similarity
messages: Belongs to the RBM48 family.

9925:STK38
gene id: 9925:STK38
uniprot id: A0A452E4G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Cytoplasm

9925:RAB27A
gene id: 9925:RAB27A
uniprot id: B6RT17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9925:CALR3
gene id: 9925:CALR3
uniprot id: A0A452EPL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9925:DAZL
gene id: 9925:DAZL
uniprot id: J9R1M9
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LOC102186703
gene id: 9925:LOC102186703
uniprot id: A0A452FFR1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:EMC4
gene id: 9925:EMC4
uniprot id: A0A452FDK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:FAM118A
gene id: 9925:FAM118A
uniprot id: A0A452EUE0
names: Similarity
messages: Belongs to the FAM118 family.

9925:GRM3
gene id: 9925:GRM3
uniprot id: A0A452F7C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9925:POLR2E
gene id: 9925:POLR2E
uniprot id: A0A452EKI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

9925:IRX5
gene id: 9925:IRX5
uniprot id: A0A452EB64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9925:KRT84
gene id: 9925:KRT84
uniprot id: A0A452FY57
names: Similarity
messages: Belongs to the intermediate filament family.

9925:SMO
gene id: 9925:SMO
uniprot id: A0A452FRY0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:LOC102180047
gene id: 9925:LOC102180047
uniprot id: A0A452DV20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:VPS28
gene id: 9925:VPS28
uniprot id: A0A452FCQ3
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

9925:PIK3CA
gene id: 9925:PIK3CA
uniprot id: A0A452EUC1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9925:LOC102189694
gene id: 9925:LOC102189694
uniprot id: A0A452E035
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CFB
gene id: 9925:CFB
uniprot id: A0A452FR95
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:MCM6
gene id: 9925:MCM6
uniprot id: A0A452F0T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9925:SERPINA10
gene id: 9925:SERPINA10
uniprot id: A0A452FT34
names: Similarity
messages: Belongs to the serpin family.

9925:IL18
gene id: 9925:IL18
uniprot id: Q3ZT29
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.

9925:TOMM20
gene id: 9925:TOMM20
uniprot id: A0A452DV43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:HCRT
gene id: 9925:HCRT
uniprot id: A0A452G0T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

9925:RPRD1B
gene id: 9925:RPRD1B
uniprot id: A0A0M3KWF7
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9925:GCAT
gene id: 9925:GCAT
uniprot id: A0A452E461
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9925:TFEC
gene id: 9925:TFEC
uniprot id: A0A452F9T1
uniprot id: A0A452F9Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9925:MED16
gene id: 9925:MED16
uniprot id: A0A452DP91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:BSX
gene id: 9925:BSX
uniprot id: A0A452DNT2
names: Subcellular Location Annotation
messages: Nucleus

9925:SEC24C
gene id: 9925:SEC24C
uniprot id: A0A452DKT9
uniprot id: A0A452DKU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9925:KIAA1324L
gene id: 9925:KIAA1324L
uniprot id: A0A452FRT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9925:ECH1
gene id: 9925:ECH1
uniprot id: A0A452G3I1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9925:IPO7
gene id: 9925:IPO7
uniprot id: A0A452FYG8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LOC102186170
gene id: 9925:LOC102186170
uniprot id: A0A452E691
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:SPNS2
gene id: 9925:SPNS2
uniprot id: A0A452G0V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9925:PLBD1
gene id: 9925:PLBD1
uniprot id: A0A452FVJ7
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9925:KDM4C
gene id: 9925:KDM4C
uniprot id: A0A452G806
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9925:AMDHD1
gene id: 9925:AMDHD1
uniprot id: A0A452FW07
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

9925:ASIP
gene id: 9925:ASIP
uniprot id: A0A0S2VHX5
names: Subcellular Location Annotation
messages: Secreted

9925:C18H19orf12
gene id: 9925:C18H19orf12
uniprot id: A0A452FTC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

9925:TAS2R60
gene id: 9925:TAS2R60
uniprot id: A0A452DRA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9925:NR1H3
gene id: 9925:NR1H3
uniprot id: F1ADJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9925:LHFPL4
gene id: 9925:LHFPL4
uniprot id: A0A452F724
names: Subcellular Location Annotation
messages: Membrane

9925:TPM3
gene id: 9925:TPM3
uniprot id: A0A452F0K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9925:KIF18A
gene id: 9925:KIF18A
uniprot id: A0A452DNR5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:C25H16orf58
gene id: 9925:C25H16orf58
uniprot id: A0A452EN93
names: Similarity
messages: Belongs to the RUS1 family.

9925:SLC9A4
gene id: 9925:SLC9A4
uniprot id: A0A452DPL5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9925:TNFSF9
gene id: 9925:TNFSF9
uniprot id: A0A452DQE5
uniprot id: A0A8C2NIC0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9925:CACNG5
gene id: 9925:CACNG5
uniprot id: A0A452EXY3
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

9925:LOC102176524
gene id: 9925:LOC102176524
uniprot id: A0A452FKJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:ACAN
gene id: 9925:ACAN
uniprot id: A0A452FGX0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:SARM1
gene id: 9925:SARM1
uniprot id: A0A452DP93
names: Similarity
messages: Belongs to the SARM1 family.

9925:TM7SF3
gene id: 9925:TM7SF3
uniprot id: A0A452E3C8
names: Subcellular Location Annotation
messages: Membrane

9925:NIPAL2
gene id: 9925:NIPAL2
uniprot id: A0A452ERT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9925:ZDHHC23
gene id: 9925:ZDHHC23
uniprot id: A0A452EI07
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:CPZ
gene id: 9925:CPZ
uniprot id: A0A452FPW2
names: Caution
names: Similarity
messages: Belongs to the peptidase M14 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TGFBR1
gene id: 9925:TGFBR1
uniprot id: A0A2S1UF15
uniprot id: A0A2S1YEP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:PGK2
gene id: 9925:PGK2
uniprot id: A0A452DPV3
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9925:SPP1
gene id: 9925:SPP1
uniprot id: A0A452EN89
uniprot id: A9YUB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

9925:NDUFC2
gene id: 9925:NDUFC2
uniprot id: A0A452G0F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9925:LOC102185882
gene id: 9925:LOC102185882
uniprot id: A0A452DRQ7
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:FAXC
gene id: 9925:FAXC
uniprot id: A0A452E2T7
names: Similarity
messages: Belongs to the FAX family.

9925:SLC16A8
gene id: 9925:SLC16A8
uniprot id: A0A452ES12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9925:NADK2
gene id: 9925:NADK2
uniprot id: A0A452EC30
uniprot id: A0A452ECI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

9925:TRDMT1
gene id: 9925:TRDMT1
uniprot id: A0A452F1T6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9925:CCZ1
gene id: 9925:CCZ1
uniprot id: A0A8C2PM16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCZ1 family.
messages: Lysosome membrane

9925:CHRNA5
gene id: 9925:CHRNA5
uniprot id: A0A452EZI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:TMEM45B
gene id: 9925:TMEM45B
uniprot id: A0A452FDT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9925:MED30
gene id: 9925:MED30
uniprot id: A0A452DZ41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9925:PRKG2
gene id: 9925:PRKG2
uniprot id: A0A452EPF5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9925:SLC46A1
gene id: 9925:SLC46A1
uniprot id: A0A452FFF6
names: Subcellular Location Annotation
messages: Membrane

9925:CORO2A
gene id: 9925:CORO2A
uniprot id: A0A452EDH6
names: Similarity
messages: Belongs to the WD repeat coronin family.

9925:REEP5
gene id: 9925:REEP5
uniprot id: A0A452FHI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9925:C9H6orf120
gene id: 9925:C9H6orf120
uniprot id: A0A452DRG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
messages: Secreted

9925:LGI3
gene id: 9925:LGI3
uniprot id: A0A452G2X6
names: Subcellular Location Annotation
messages: Secreted

9925:CNFN
gene id: 9925:CNFN
uniprot id: A0A452ELR1
names: Similarity
messages: Belongs to the cornifelin family.

9925:NFRKB
gene id: 9925:NFRKB
uniprot id: A0A452FFG4
names: Subcellular Location Annotation
messages: Nucleus

9925:TREX1
gene id: 9925:TREX1
uniprot id: A0A452DWH0
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9925:RBM42
gene id: 9925:RBM42
uniprot id: A0A452E0C8
uniprot id: A0A452E0I3
names: Similarity
messages: Belongs to the RRM RBM42 family.

9925:DKK2
gene id: 9925:DKK2
uniprot id: A0A452G5G3
names: Similarity
messages: Belongs to the dickkopf family.

9925:KPNA3
gene id: 9925:KPNA3
uniprot id: A0A452FEC0
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9925:CLDN4
gene id: 9925:CLDN4
uniprot id: A0A452DQB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:MCIDAS
gene id: 9925:MCIDAS
uniprot id: A0A452FDV9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the geminin family.
messages: Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.
messages: Nucleus

9925:EIF4G1
gene id: 9925:EIF4G1
uniprot id: A0A452E1M0
uniprot id: A0A452E1R5
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9925:LOC102172789
gene id: 9925:LOC102172789
uniprot id: A0A8C2S6C6
uniprot id: A0A8C2S7E4
names: Similarity
messages: Belongs to the Luc7 family.

9925:HBEGF
gene id: 9925:HBEGF
uniprot id: A0A452FPQ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CLDN20
gene id: 9925:CLDN20
uniprot id: A0A452DQ69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:TCTEX1D4
gene id: 9925:TCTEX1D4
uniprot id: A0A452E072
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9925:MRPL58
gene id: 9925:MRPL58
uniprot id: A0A452F448
names: Subcellular Location Annotation
messages: Mitochondrion

9925:STK40
gene id: 9925:STK40
uniprot id: A0A452FGC2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9925:TUSC3
gene id: 9925:TUSC3
uniprot id: A0A452FM74
uniprot id: A0A8C2XYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:FDFT1
gene id: 9925:FDFT1
uniprot id: A0A452FY30
uniprot id: A0A452FYC7
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9925:FABP5
gene id: 9925:FABP5
uniprot id: A0A452FM00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:GALE
gene id: 9925:GALE
uniprot id: A0A452EKH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9925:STON2
gene id: 9925:STON2
uniprot id: A0A452E930
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

9925:GALNT10
gene id: 9925:GALNT10
uniprot id: A0A452EYJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:PIGM
gene id: 9925:PIGM
uniprot id: A0A452DSW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9925:SFRP1
gene id: 9925:SFRP1
uniprot id: A0A452EKX5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:DYRK3
gene id: 9925:DYRK3
uniprot id: A0A452FAL4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9925:AP3B1
gene id: 9925:AP3B1
uniprot id: A0A452F6M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9925:TP53I11
gene id: 9925:TP53I11
uniprot id: A0A452F2J0
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102175876
gene id: 9925:LOC102175876
uniprot id: P02077
uniprot id: Q1KZF3
names: Function
names: Polymorphism
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.
messages: There are at least three alleles. The sequence shown is that of allele A.

9925:DOK5
gene id: 9925:DOK5
uniprot id: A0A452F9V2
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9925:KCNJ13
gene id: 9925:KCNJ13
uniprot id: A0A452F407
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9925:TEC
gene id: 9925:TEC
uniprot id: A0A452FPR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:LOC102173687
gene id: 9925:LOC102173687
uniprot id: A0A452FIB7
names: Similarity
messages: Belongs to the TACO1 family.

9925:PRDX6
gene id: 9925:PRDX6
uniprot id: A0A452EUX2
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9925:HNRNPD
gene id: 9925:HNRNPD
uniprot id: A0A452FMV1
uniprot id: A0A452FMZ4
uniprot id: A0A452FN01
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:CUL1
gene id: 9925:CUL1
uniprot id: A0A452G4S8
names: Similarity
messages: Belongs to the cullin family.

9925:C15H11orf88
gene id: 9925:C15H11orf88
uniprot id: A0A452GA37
names: Similarity
messages: Belongs to the HOATZ family.

9925:ITM2C
gene id: 9925:ITM2C
uniprot id: A0A452FAP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9925:SQSTM1
gene id: 9925:SQSTM1
uniprot id: A0A452FQZ0
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9925:DDX41
gene id: 9925:DDX41
uniprot id: A0A452E157
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

9925:HTR1E
gene id: 9925:HTR1E
uniprot id: A0A452DZJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:LOC102183585
gene id: 9925:LOC102183585
uniprot id: A0A452DUD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TMEM97
gene id: 9925:TMEM97
uniprot id: A0A452FKN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM97/sigma-2 receptor family.
messages: Endoplasmic reticulum membrane
messages: Interacts with NPC1.
messages: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

9925:INO80D
gene id: 9925:INO80D
uniprot id: A0A452E4Z5
names: Subcellular Location Annotation
messages: Nucleus

9925:ELOVL2
gene id: 9925:ELOVL2
uniprot id: A0A452DNY4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9925:EPHB1
gene id: 9925:EPHB1
uniprot id: A0A452F900
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9925:CHMP7
gene id: 9925:CHMP7
uniprot id: A0A452FZ86
names: Similarity
messages: Belongs to the SNF7 family.

9925:LOC108635821
gene id: 9925:LOC108635821
uniprot id: A0A452FCF1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9925:JPH1
gene id: 9925:JPH1
uniprot id: A0A452F2J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9925:HSD17B13
gene id: 9925:HSD17B13
uniprot id: A0A452FF49
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:HFE2
gene id: 9925:HFE2
uniprot id: A0A452E3M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9925:FOXN3
gene id: 9925:FOXN3
uniprot id: A0A452DTI7
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102170144
gene id: 9925:LOC102170144
uniprot id: A0A452FFS9
uniprot id: A0A452FGA4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9925:MDFI
gene id: 9925:MDFI
uniprot id: A0A452FDQ7
names: Similarity
messages: Belongs to the MDFI family.

9925:ORMDL3
gene id: 9925:ORMDL3
uniprot id: A0A452G8N4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

9925:TMEM88
gene id: 9925:TMEM88
uniprot id: A0A452EZL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9925:LOC102169111
gene id: 9925:LOC102169111
uniprot id: A0A452DXU6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MIXL1
gene id: 9925:MIXL1
uniprot id: A0A8C2PH41
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102177263
gene id: 9925:LOC102177263
uniprot id: A0A452DZ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9925:FGF9
gene id: 9925:FGF9
uniprot id: A0A452FF06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
messages: Secreted

9925:LOC102190133
gene id: 9925:LOC102190133
uniprot id: A0A452FNU5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:TMOD3
gene id: 9925:TMOD3
uniprot id: A0A452FHX1
names: Subcellular Location Annotation
messages: cytoskeleton

9925:LOC102168680
gene id: 9925:LOC102168680
uniprot id: C6ZP43
uniprot id: P0CH25
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Adult goat and other mammalian species produce unequal amounts of alpha-globin from non-allelic loci.
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9925:PPP1R9B
gene id: 9925:PPP1R9B
uniprot id: A0A452G4T2
names: Subcellular Location Annotation
messages: cytoskeleton

9925:ZNRF4
gene id: 9925:ZNRF4
uniprot id: A0A8C2P9F3
names: Subcellular Location Annotation
messages: Membrane

9925:MCM4
gene id: 9925:MCM4
uniprot id: A0A8C2NWA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9925:B4GALNT3
gene id: 9925:B4GALNT3
uniprot id: A0A452EX89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

9925:PLEKHA8
gene id: 9925:PLEKHA8
uniprot id: A0A452FQC3
names: Subcellular Location Annotation
messages: Membrane
messages: trans-Golgi network membrane

9925:DHRS7
gene id: 9925:DHRS7
uniprot id: A0A452G765
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:PHACTR2
gene id: 9925:PHACTR2
uniprot id: A0A452EJT7
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9925:DOC2B
gene id: 9925:DOC2B
uniprot id: A0A452DZM7
names: Subcellular Location Annotation
messages: Membrane

9925:PON2
gene id: 9925:PON2
uniprot id: A0A452FRQ4
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9925:PIH1D2
gene id: 9925:PIH1D2
uniprot id: A0A452EKE1
names: Similarity
messages: Belongs to the PIH1 family.

9925:SLC35C2
gene id: 9925:SLC35C2
uniprot id: A0A452EG32
names: Subcellular Location Annotation
messages: Membrane

9925:ZSCAN29
gene id: 9925:ZSCAN29
uniprot id: A0A452FH27
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9925:LOC102169970
gene id: 9925:LOC102169970
uniprot id: A0A452DNT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102180474
gene id: 9925:LOC102180474
uniprot id: A0A452E8B1
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9925:MBOAT7
gene id: 9925:MBOAT7
uniprot id: A0A452FD06
names: Subcellular Location Annotation
messages: Membrane

9925:TMEM126A
gene id: 9925:TMEM126A
uniprot id: A0A452G5S2
names: Subcellular Location Annotation
messages: Membrane

9925:SEC16A
gene id: 9925:SEC16A
uniprot id: A0A452FD05
uniprot id: A0A452FDB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

9925:ATXN10
gene id: 9925:ATXN10
uniprot id: A0A452EMJ5
names: Function
names: Similarity
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.

9925:MFN2
gene id: 9925:MFN2
uniprot id: A0A452EVG6
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9925:SNX20
gene id: 9925:SNX20
uniprot id: A0A452G5M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9925:REEP2
gene id: 9925:REEP2
uniprot id: A0A452EXJ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:SHROOM3
gene id: 9925:SHROOM3
uniprot id: A0A452FGS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9925:GPI
gene id: 9925:GPI
uniprot id: A0A452EUU0
names: Similarity
messages: Belongs to the GPI family.

9925:LOC108633809
gene id: 9925:LOC108633809
uniprot id: A0A452GAH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9925:PABPC1
gene id: 9925:PABPC1
uniprot id: A0A452FUU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9925:LOC108636726
gene id: 9925:LOC108636726
uniprot id: A0A452F9N2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9925:PER3
gene id: 9925:PER3
uniprot id: A0A452FMZ6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:BMPR1B
gene id: 9925:BMPR1B
uniprot id: A0A452F241
uniprot id: A0A452F2E9
uniprot id: B5AFX6
uniprot id: Q4PRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:BAX
gene id: 9925:BAX
uniprot id: A0A076FVB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9925:LOC102177295
gene id: 9925:LOC102177295
uniprot id: A0A452FTL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9925:PARPBP
gene id: 9925:PARPBP
uniprot id: A0A452FRI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9925:N6AMT1
gene id: 9925:N6AMT1
uniprot id: A0A452EV03
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

9925:BUD13
gene id: 9925:BUD13
uniprot id: A0A452E8F6
names: Similarity
messages: Belongs to the CWC26 family.

9925:DTNB
gene id: 9925:DTNB
uniprot id: A0A452E4X9
uniprot id: A0A452E4Z8
uniprot id: A0A452E517
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9925:NOP14
gene id: 9925:NOP14
uniprot id: A0A452G8Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9925:OGDHL
gene id: 9925:OGDHL
uniprot id: A0A452FP45
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9925:PDE8A
gene id: 9925:PDE8A
uniprot id: A0A452F1C2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:CRYBB2
gene id: 9925:CRYBB2
uniprot id: A0A452EUU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9925:TXNRD1
gene id: 9925:TXNRD1
uniprot id: A0A452FGF2
uniprot id: A0A452FGQ8
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

9925:TRIP12
gene id: 9925:TRIP12
uniprot id: A0A452EH82
uniprot id: A0A452EH96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9925:CACNG6
gene id: 9925:CACNG6
uniprot id: A0A452DVC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

9925:PEA15
gene id: 9925:PEA15
uniprot id: A0A452FWG9
names: Subcellular Location Annotation
messages: Cytoplasm

9925:PPP4R3A
gene id: 9925:PPP4R3A
uniprot id: A0A452E340
names: Similarity
messages: Belongs to the SMEK family.

9925:CERS6
gene id: 9925:CERS6
uniprot id: A0A452G6A8
uniprot id: A0A452G6G4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9925:CSPG4
gene id: 9925:CSPG4
uniprot id: A0A452FNM1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SPACA4
gene id: 9925:SPACA4
uniprot id: A0A452E0J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9925:RIOK1
gene id: 9925:RIOK1
uniprot id: A0A452DMK3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9925:TIPIN
gene id: 9925:TIPIN
uniprot id: A0A452DLQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9925:ACSM5
gene id: 9925:ACSM5
uniprot id: A0A452EMS4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:MSTN
gene id: 9925:MSTN
uniprot id: A5YU17
uniprot id: Q6T5B8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted
messages: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

9925:SBNO2
gene id: 9925:SBNO2
uniprot id: A0A452G640
names: Similarity
messages: Belongs to the SBNO family.

9925:ERF
gene id: 9925:ERF
uniprot id: A0A452FAM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:MPPED1
gene id: 9925:MPPED1
uniprot id: A0A452G315
names: Similarity
messages: Belongs to the UPF0046 family.

9925:EME1
gene id: 9925:EME1
uniprot id: A0A452EUD1
names: Similarity
messages: Belongs to the EME1/MMS4 family.

9925:SMOC1
gene id: 9925:SMOC1
uniprot id: A0A452E8Q4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:IBSP
gene id: 9925:IBSP
uniprot id: A0A452FIP9
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9925:DTD2
gene id: 9925:DTD2
uniprot id: A0A452E953
names: Similarity
messages: Belongs to the DTD family.

9925:LOC102168966
gene id: 9925:LOC102168966
uniprot id: A0A452FQQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:SLBP
gene id: 9925:SLBP
uniprot id: A0A452F9F1
names: Similarity
messages: Belongs to the SLBP family.

9925:NTRK2
gene id: 9925:NTRK2
uniprot id: A0A452FRR2
uniprot id: A0A452FRX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

9925:LOC102169688
gene id: 9925:LOC102169688
uniprot id: A0A452E8S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PROS1
gene id: 9925:PROS1
uniprot id: A0A452E432
names: Caution
names: Function
messages: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TK1
gene id: 9925:TK1
uniprot id: A0A452EXI1
names: Similarity
messages: Belongs to the thymidine kinase family.

9925:KRT77
gene id: 9925:KRT77
uniprot id: A0A452ELA7
names: Similarity
messages: Belongs to the intermediate filament family.

9925:CHMP2A
gene id: 9925:CHMP2A
uniprot id: A0A452E6P7
names: Similarity
messages: Belongs to the SNF7 family.

9925:SLC27A4
gene id: 9925:SLC27A4
uniprot id: A0A452G7M8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:SLC25A38
gene id: 9925:SLC25A38
uniprot id: A0A452FQZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9925:MFAP3
gene id: 9925:MFAP3
uniprot id: A0A452F947
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:LOC102178046
gene id: 9925:LOC102178046
uniprot id: A0A452DVU0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102189116
gene id: 9925:LOC102189116
uniprot id: A0A452FGA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9925:LOC102180889
gene id: 9925:LOC102180889
uniprot id: A0A452FPP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9925:NDFIP2
gene id: 9925:NDFIP2
uniprot id: A0A452EF12
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9925:ACVR2A
gene id: 9925:ACVR2A
uniprot id: A0A452EGE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:STMN1
gene id: 9925:STMN1
uniprot id: A0A452FTR2
names: Similarity
messages: Belongs to the stathmin family.

9925:EPB41L5
gene id: 9925:EPB41L5
uniprot id: A0A452EJV6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Photoreceptor inner segment
messages: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.

9925:RFTN1
gene id: 9925:RFTN1
uniprot id: A0A452EF47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9925:TRAPPC3L
gene id: 9925:TRAPPC3L
uniprot id: A0A452FIL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9925:BRF2
gene id: 9925:BRF2
uniprot id: A0A452DRN4
names: Similarity
messages: Belongs to the TFIIB family.

9925:OSBPL8
gene id: 9925:OSBPL8
uniprot id: A0A452E402
uniprot id: A0A452E484
names: Similarity
messages: Belongs to the OSBP family.

9925:BTF3
gene id: 9925:BTF3
uniprot id: A0A452FEX4
names: Similarity
messages: Belongs to the NAC-beta family.

9925:KCNK6
gene id: 9925:KCNK6
uniprot id: A0A452FJY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:MARK3
gene id: 9925:MARK3
uniprot id: A0A452F5H0
uniprot id: A0A452F5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9925:LOC102189777
gene id: 9925:LOC102189777
uniprot id: A0A452EAW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102186657
gene id: 9925:LOC102186657
uniprot id: A0A452DX72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:LOC102178618
gene id: 9925:LOC102178618
uniprot id: A0A452FGY0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9925:LOC102187067
gene id: 9925:LOC102187067
uniprot id: A0A452DXM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PHLDA3
gene id: 9925:PHLDA3
uniprot id: A0A452EGJ6
names: Subcellular Location Annotation
messages: Cytoplasm

9925:CHST1
gene id: 9925:CHST1
uniprot id: A0A452DXK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9925:DERL2
gene id: 9925:DERL2
uniprot id: A0A452F9A2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:DTX4
gene id: 9925:DTX4
uniprot id: A0A452FKI9
uniprot id: A0A452FLG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9925:AMIGO1
gene id: 9925:AMIGO1
uniprot id: A0A452DM39
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9925:UBIAD1
gene id: 9925:UBIAD1
uniprot id: A0A452E7T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9925:KRTAP11-1
gene id: 9925:KRTAP11-1
uniprot id: Q6R648
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the PMG family.
messages: In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of wool keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Wool.

9925:SAP30L
gene id: 9925:SAP30L
uniprot id: A0A452EA60
names: Similarity
messages: Belongs to the SAP30 family.

9925:EXOSC2
gene id: 9925:EXOSC2
uniprot id: A0A452FIA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9925:MTMR7
gene id: 9925:MTMR7
uniprot id: A0A452DQI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9925:HTR3A
gene id: 9925:HTR3A
uniprot id: A0A452G324
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:APOC4
gene id: 9925:APOC4
uniprot id: A0A8C2RQ65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

9925:UROS
gene id: 9925:UROS
uniprot id: A0A452FM92
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9925:ELF1
gene id: 9925:ELF1
uniprot id: A0A452FME7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:ADCY9
gene id: 9925:ADCY9
uniprot id: A0A452E8C5
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9925:BRD1
gene id: 9925:BRD1
uniprot id: A0A452EM03
names: Subcellular Location Annotation
messages: Nucleus

9925:AXIN2
gene id: 9925:AXIN2
uniprot id: A0A452FEH8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:TRABD2B
gene id: 9925:TRABD2B
uniprot id: A0A452EV31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9925:GPR6
gene id: 9925:GPR6
uniprot id: A0A452E1Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:KRR1
gene id: 9925:KRR1
uniprot id: A0A452F5I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9925:LRRC8E
gene id: 9925:LRRC8E
uniprot id: A0A452FCZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9925:CKMT1A
gene id: 9925:CKMT1A
uniprot id: A0A452F5T2
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9925:CLCA1
gene id: 9925:CLCA1
uniprot id: A0A452E9S7
names: Similarity
messages: Belongs to the CLCR family.

9925:SERPINF1
gene id: 9925:SERPINF1
uniprot id: A0A452G7E7
names: Similarity
messages: Belongs to the serpin family.

9925:RRP7A
gene id: 9925:RRP7A
uniprot id: A0A452G934
names: Similarity
messages: Belongs to the RRP7 family.

9925:CACYBP
gene id: 9925:CACYBP
uniprot id: A0A452FJL5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9925:CPO
gene id: 9925:CPO
uniprot id: A0A452FF61
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:KCNH8
gene id: 9925:KCNH8
uniprot id: A0A452F7J8
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9925:ART4
gene id: 9925:ART4
uniprot id: A0A8C2NBI5
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9925:ARF3
gene id: 9925:ARF3
uniprot id: A0A452F8V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:ARID1A
gene id: 9925:ARID1A
uniprot id: A0A452E5F7
names: Subcellular Location Annotation
messages: Nucleus

9925:SLC18A2
gene id: 9925:SLC18A2
uniprot id: A0A452FWY0
names: Subcellular Location Annotation
messages: Membrane

9925:ATP11B
gene id: 9925:ATP11B
uniprot id: A0A452DT58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9925:ADCYAP1
gene id: 9925:ADCYAP1
uniprot id: A0A452DLC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucagon family.
messages: Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
messages: Secreted

9925:TINAG
gene id: 9925:TINAG
uniprot id: A0A452E5Y6
names: Similarity
messages: Belongs to the peptidase C1 family.

9925:ZDHHC16
gene id: 9925:ZDHHC16
uniprot id: A0A452FYM8
uniprot id: A0A452FZC6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:TSHB
gene id: 9925:TSHB
uniprot id: I3RYY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9925:ANKRD34C
gene id: 9925:ANKRD34C
uniprot id: A0A452E181
names: Similarity
messages: Belongs to the ANKRD34 family.

9925:CMTM3
gene id: 9925:CMTM3
uniprot id: A0A452F9B4
names: Subcellular Location Annotation
messages: Membrane

9925:GLUD1
gene id: 9925:GLUD1
uniprot id: A0A452DLE1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

9925:ACAA2
gene id: 9925:ACAA2
uniprot id: A0A452FY07
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9925:IDO1
gene id: 9925:IDO1
uniprot id: W5U964
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9925:FXYD1
gene id: 9925:FXYD1
uniprot id: A0A8C2PG16
names: Similarity
messages: Belongs to the FXYD family.

9925:POLR3K
gene id: 9925:POLR3K
uniprot id: A0A452FDS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9925:FAM53C
gene id: 9925:FAM53C
uniprot id: A0A452FH57
names: Similarity
messages: Belongs to the FAM53 family.

9925:SPIB
gene id: 9925:SPIB
uniprot id: A0A452F114
uniprot id: A0A8C2SKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:NCK1
gene id: 9925:NCK1
uniprot id: A0A452ECW4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9925:SLC25A3
gene id: 9925:SLC25A3
uniprot id: A0A452G9E1
uniprot id: A0A452G9K3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9925:MOCOS
gene id: 9925:MOCOS
uniprot id: A0A452DN35
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

9925:REV1
gene id: 9925:REV1
uniprot id: A0A452EDA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

9925:LOC102169976
gene id: 9925:LOC102169976
uniprot id: A0A452F0F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:STX3
gene id: 9925:STX3
uniprot id: A0A452EXQ4
names: Similarity
messages: Belongs to the syntaxin family.

9925:LOC102180368
gene id: 9925:LOC102180368
uniprot id: A0A452FIN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:ARL5C
gene id: 9925:ARL5C
uniprot id: A0A452DW46
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9925:TCEANC2
gene id: 9925:TCEANC2
uniprot id: A0A452G861
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC108633910
gene id: 9925:LOC108633910
uniprot id: A0A452DS03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:SEBOX
gene id: 9925:SEBOX
uniprot id: A0A452G0N1
names: Subcellular Location Annotation
messages: Nucleus

9925:KCNK9
gene id: 9925:KCNK9
uniprot id: A0A452FMB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9925:BDH1
gene id: 9925:BDH1
uniprot id: A0A452G711
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:GHR
gene id: 9925:GHR
uniprot id: A0A452F728
uniprot id: A7KT21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

9925:GPN3
gene id: 9925:GPN3
uniprot id: A0A452EIF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9925:FAT1
gene id: 9925:FAT1
uniprot id: A0A452F1R8
uniprot id: A0A452F2D9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LYPLA1
gene id: 9925:LYPLA1
uniprot id: A0A452DZD5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9925:LOC102171995
gene id: 9925:LOC102171995
uniprot id: A0A452DQV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102177275
gene id: 9925:LOC102177275
uniprot id: A0A452E4U1
names: Similarity
messages: Belongs to the intermediate filament family.

9925:ARL6IP5
gene id: 9925:ARL6IP5
uniprot id: A0A452FJJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9925:FKTN
gene id: 9925:FKTN
uniprot id: A0A452DZJ5
names: Similarity
messages: Belongs to the LicD transferase family.

9925:RIF1
gene id: 9925:RIF1
uniprot id: A0A452FDE0
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9925:STXBP5L
gene id: 9925:STXBP5L
uniprot id: A0A452FK37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9925:LOC102174291
gene id: 9925:LOC102174291
uniprot id: A0A452E6A2
names: Similarity
messages: Belongs to the serpin family.

9925:SEMA6D
gene id: 9925:SEMA6D
uniprot id: A0A452ED00
uniprot id: A0A452ED64
uniprot id: A0A452EDH3
uniprot id: A0A8C2NSL3
uniprot id: A0A8C2NUH6
uniprot id: A0A8C2NW84
uniprot id: A0A8C2QUT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CACNB2
gene id: 9925:CACNB2
uniprot id: A0A452DN16
uniprot id: A0A452DN38
uniprot id: A0A452DN74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
messages: sarcolemma

9925:HSPE1
gene id: 9925:HSPE1
uniprot id: A0A8C2NRB8
names: Similarity
messages: Belongs to the GroES chaperonin family.

9925:CDCA7
gene id: 9925:CDCA7
uniprot id: A0A452G918
uniprot id: A0A452G9I4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:TRUB2
gene id: 9925:TRUB2
uniprot id: A0A452FH64
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9925:L3HYPDH
gene id: 9925:L3HYPDH
uniprot id: A0A452FAK7
names: Similarity
messages: Belongs to the proline racemase family.

9925:AQP4
gene id: 9925:AQP4
uniprot id: A0A452E2K9
uniprot id: A0A452E2M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9925:PLAU
gene id: 9925:PLAU
uniprot id: A0A452DLQ8
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9925:COPS2
gene id: 9925:COPS2
uniprot id: A0A452FJG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

9925:LOC102188254
gene id: 9925:LOC102188254
uniprot id: A0A452DTA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:YPEL3
gene id: 9925:YPEL3
uniprot id: A0A452FKY5
names: Similarity
messages: Belongs to the yippee family.

9925:CLRN1
gene id: 9925:CLRN1
uniprot id: A0A452E3A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9925:WASF3
gene id: 9925:WASF3
uniprot id: A0A452F1M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9925:ARMT1
gene id: 9925:ARMT1
uniprot id: A0A452FYL1
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9925:LOC102173288
gene id: 9925:LOC102173288
uniprot id: A0A452EB91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:BOK
gene id: 9925:BOK
uniprot id: A0A452G7C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9925:TBCB
gene id: 9925:TBCB
uniprot id: A0A452FXK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

9925:KLC4
gene id: 9925:KLC4
uniprot id: A0A452E4U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9925:FAM83B
gene id: 9925:FAM83B
uniprot id: A0A452FB00
names: Similarity
messages: Belongs to the FAM83 family.

9925:MMP19
gene id: 9925:MMP19
uniprot id: A0A8C2N709
names: Similarity
messages: Belongs to the peptidase M10A family.

9925:LOC102188370
gene id: 9925:LOC102188370
uniprot id: A0A452F2I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9925:LAP3
gene id: 9925:LAP3
uniprot id: A0A452DVV1
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9925:UGGT1
gene id: 9925:UGGT1
uniprot id: A0A452F043
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9925:RNF34
gene id: 9925:RNF34
uniprot id: A0A452E2L7
names: Subcellular Location Annotation
messages: Cell membrane

9925:ACYP1
gene id: 9925:ACYP1
uniprot id: A0A452FK47
names: Similarity
messages: Belongs to the acylphosphatase family.

9925:PHACTR1
gene id: 9925:PHACTR1
uniprot id: A0A452FLK5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

9925:ITGA10
gene id: 9925:ITGA10
uniprot id: A0A452GAL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:LOC102169288
gene id: 9925:LOC102169288
uniprot id: A0A452E7P3
names: Similarity
messages: Belongs to the HPF1 family.

9925:SNX2
gene id: 9925:SNX2
uniprot id: A0A452DU06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9925:MTMR12
gene id: 9925:MTMR12
uniprot id: A0A452DXF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Sarcoplasmic reticulum
messages: sarcomere

9925:HIKESHI
gene id: 9925:HIKESHI
uniprot id: A0A452FU94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9925:TNFSF10
gene id: 9925:TNFSF10
uniprot id: A0A452EXA6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9925:LOC102189040
gene id: 9925:LOC102189040
uniprot id: A0A452DTY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:PDZK1IP1
gene id: 9925:PDZK1IP1
uniprot id: A0A452E2H5
uniprot id: A0A8C2NJE5
names: Subcellular Location Annotation
messages: Membrane

9925:EEF1A2
gene id: 9925:EEF1A2
uniprot id: A0A452EWA5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9925:RNF20
gene id: 9925:RNF20
uniprot id: A0A452EEV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9925:HVCN1
gene id: 9925:HVCN1
uniprot id: A0A8C2S470
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9925:CENPL
gene id: 9925:CENPL
uniprot id: A0A8C2R7S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9925:ALDOA
gene id: 9925:ALDOA
uniprot id: A0A452EGY9
uniprot id: A0A452EH63
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9925:ARPC1B
gene id: 9925:ARPC1B
uniprot id: A0A452FGQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9925:PLCB4
gene id: 9925:PLCB4
uniprot id: A0A452FTU9
uniprot id: A0A452FU18
uniprot id: A0A452FUL5
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9925:UTP15
gene id: 9925:UTP15
uniprot id: A0A452EXS0
names: Subcellular Location Annotation
messages: nucleolus

9925:EIF5A2
gene id: 9925:EIF5A2
uniprot id: A0A452F0Q3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

9925:DDX49
gene id: 9925:DDX49
uniprot id: A0A452FBG4
names: Similarity
messages: Belongs to the DEAD box helicase family.

9925:LOC102171420
gene id: 9925:LOC102171420
uniprot id: A0A452DVD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:HSCB
gene id: 9925:HSCB
uniprot id: A0A452G4V6
names: Similarity
messages: Belongs to the HscB family.

9925:LOC102173645
gene id: 9925:LOC102173645
uniprot id: A0A452E0Q4
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9925:KIAA0922
gene id: 9925:KIAA0922
uniprot id: A0A452FCL4
names: Similarity
messages: Belongs to the TMEM131 family.

9925:DYRK2
gene id: 9925:DYRK2
uniprot id: A0A452FX07
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9925:BLM
gene id: 9925:BLM
uniprot id: A0A452E3F0
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9925:CSF1
gene id: 9925:CSF1
uniprot id: A0A452GAN0
names: Function
names: Subunit
messages: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
messages: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.

9925:FAM69B
gene id: 9925:FAM69B
uniprot id: A0A452EKF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

9925:FAM49B
gene id: 9925:FAM49B
uniprot id: A0A452DS77
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9925:LOC102181154
gene id: 9925:LOC102181154
uniprot id: A0A452EYB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:EGFL8
gene id: 9925:EGFL8
uniprot id: A0A452DPS6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC108633351
gene id: 9925:LOC108633351
uniprot id: A0A452G1M3
names: Similarity
messages: Belongs to the alkaline phosphatase family.

9925:AP2M1
gene id: 9925:AP2M1
uniprot id: A0A452F6X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9925:ATP5J
gene id: 9925:ATP5J
uniprot id: A0A452FLK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9925:SPTLC2
gene id: 9925:SPTLC2
uniprot id: A0A452FLI5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9925:SERINC3
gene id: 9925:SERINC3
uniprot id: A0A452FEG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9925:PDC
gene id: 9925:PDC
uniprot id: A0A452E229
names: Similarity
messages: Belongs to the phosducin family.

9925:DPM1
gene id: 9925:DPM1
uniprot id: A0A452FXS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9925:ENO3
gene id: 9925:ENO3
uniprot id: A0A452FB24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9925:CRYBA2
gene id: 9925:CRYBA2
uniprot id: A0A452FDN5
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:WNT10A
gene id: 9925:WNT10A
uniprot id: A0A452FQH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:GALNT1
gene id: 9925:GALNT1
uniprot id: A0A452F6U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:XPO6
gene id: 9925:XPO6
uniprot id: A0A452FN43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9925:PRPSAP2
gene id: 9925:PRPSAP2
uniprot id: A0A452FQC6
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9925:SLC25A24
gene id: 9925:SLC25A24
uniprot id: A0A452FU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:LOC102181270
gene id: 9925:LOC102181270
uniprot id: A0A452FCC9
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:MURC
gene id: 9925:MURC
uniprot id: A0A452E015
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

9925:ADAMTS10
gene id: 9925:ADAMTS10
uniprot id: A0A452G1A3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:KAT7
gene id: 9925:KAT7
uniprot id: A0A452G4Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9925:LOC106503499
gene id: 9925:LOC106503499
uniprot id: A0A452E3I1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:KIF20A
gene id: 9925:KIF20A
uniprot id: A0A452FTK7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:FAM120B
gene id: 9925:FAM120B
uniprot id: A0A452G7L3
uniprot id: A0A452G7N4
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9925:ITPRIP
gene id: 9925:ITPRIP
uniprot id: A0A452FFN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Cell membrane
messages: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
messages: Membrane
messages: Nucleus outer membrane

9925:FRRS1
gene id: 9925:FRRS1
uniprot id: A0A452G9W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9925:TMEM265
gene id: 9925:TMEM265
uniprot id: A0A452EEX2
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9925:IFT20
gene id: 9925:IFT20
uniprot id: A0A452E7S7
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9925:HOXA6
gene id: 9925:HOXA6
uniprot id: A0A452ER78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:MME
gene id: 9925:MME
uniprot id: A0A452F4Y2
names: Cofactor
messages: Binds 1 zinc ion per subunit.

9925:CREM
gene id: 9925:CREM
uniprot id: E0AEZ7
names: Subcellular Location Annotation
messages: Nucleus

9925:REEP4
gene id: 9925:REEP4
uniprot id: A0A452G287
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:MANBA
gene id: 9925:MANBA
uniprot id: Q95327
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Defects in MANBA cause beta-mannosidosis, a severe disorder that affects peripheral and central nervous system myelin resulting in tremor, nystagmus, ataxia and early death. The primary storage products associated with the enzyme deficiency are the trisaccharide Man-beta-1-4-GlcNAc-beta-1-4-GlcNAc and the disaccharide Man-beta-1-4-GlcNAc.
messages: Detected in kidney (at protein level) (PubMed:1556126). Found in spleen and to a lesser extent in liver. Not detected in kidney or brain.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.
messages: N-glycosylated.

9925:TMEM107
gene id: 9925:TMEM107
uniprot id: A0A452G122
names: Subcellular Location Annotation
messages: Membrane

9925:MPPED2
gene id: 9925:MPPED2
uniprot id: A0A452EZG7
names: Similarity
messages: Belongs to the UPF0046 family.

9925:ODF2L
gene id: 9925:ODF2L
uniprot id: A0A452G4Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9925:CDK6
gene id: 9925:CDK6
uniprot id: A0A452E8F3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102175610
gene id: 9925:LOC102175610
uniprot id: A0A452EN08
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9925:ABL2
gene id: 9925:ABL2
uniprot id: A0A452EDR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:SLC18A3
gene id: 9925:SLC18A3
uniprot id: A0A452E3B9
names: Subcellular Location Annotation
messages: Membrane

9925:DEGS2
gene id: 9925:DEGS2
uniprot id: A0A452FGE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:ZDHHC5
gene id: 9925:ZDHHC5
uniprot id: A0A452EX88
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:RNF114
gene id: 9925:RNF114
uniprot id: A0A452E8Q6
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

9925:KCNH4
gene id: 9925:KCNH4
uniprot id: A0A452DQZ2
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9925:GRM1
gene id: 9925:GRM1
uniprot id: A0A452G1X1
uniprot id: A0A452G284
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9925:LOC102179815
gene id: 9925:LOC102179815
uniprot id: A0A452G4X0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

9925:WISP3
gene id: 9925:WISP3
uniprot id: A0A452G2L8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:COPS6
gene id: 9925:COPS6
uniprot id: A0A8C2S956
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

9925:SYT1
gene id: 9925:SYT1
uniprot id: A0A452GBF6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

9925:CTSH
gene id: 9925:CTSH
uniprot id: A0A060INS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9925:TBL3
gene id: 9925:TBL3
uniprot id: A0A452DVP0
names: Subcellular Location Annotation
messages: nucleolus

9925:PYROXD1
gene id: 9925:PYROXD1
uniprot id: A0A452FF92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9925:SUCNR1
gene id: 9925:SUCNR1
uniprot id: A0A452DVW0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:MFSD8
gene id: 9925:MFSD8
uniprot id: A0A452FX70
names: Subcellular Location Annotation
messages: Membrane

9925:SNRPN
gene id: 9925:SNRPN
uniprot id: A0A452F0H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9925:HOXB5
gene id: 9925:HOXB5
uniprot id: A0A452FRZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:CPLX3
gene id: 9925:CPLX3
uniprot id: A0A452DLN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9925:LOC108636623
gene id: 9925:LOC108636623
uniprot id: A0A452DYA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:COPS7A
gene id: 9925:COPS7A
uniprot id: A0A452EF68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9925:SPPL2C
gene id: 9925:SPPL2C
uniprot id: A0A452DNA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9925:ACVR1C
gene id: 9925:ACVR1C
uniprot id: A0A452EFE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:LOC102182872
gene id: 9925:LOC102182872
uniprot id: A0A452ECF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102186288
gene id: 9925:LOC102186288
uniprot id: A0A452G6B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9925:SIVA1
gene id: 9925:SIVA1
uniprot id: A0A452FIV7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus

9925:DTNA
gene id: 9925:DTNA
uniprot id: A0A452EI67
uniprot id: A0A452EIE1
uniprot id: A0A452EIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9925:CXCL10
gene id: 9925:CXCL10
uniprot id: Q867B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9925:LOC102188021
gene id: 9925:LOC102188021
uniprot id: A0A452FWH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9925:BIRC3
gene id: 9925:BIRC3
uniprot id: A0A452EAU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9925:POFUT1
gene id: 9925:POFUT1
uniprot id: A0A452FHC7
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

9925:LOC102174032
gene id: 9925:LOC102174032
uniprot id: A0A452EEJ9
names: Similarity
messages: Belongs to the peptidase C48 family.

9925:CXCR5
gene id: 9925:CXCR5
uniprot id: A0A452FFA2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:SEC23A
gene id: 9925:SEC23A
uniprot id: A0A452G819
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9925:CPLX2
gene id: 9925:CPLX2
uniprot id: A0A452G5P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9925:GAL
gene id: 9925:GAL
uniprot id: A0A452G0F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

9925:UHRF2
gene id: 9925:UHRF2
uniprot id: A0A452EPR0
names: Subcellular Location Annotation
messages: Nucleus

9925:USP1
gene id: 9925:USP1
uniprot id: A0A452EU25
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9925:CRB1
gene id: 9925:CRB1
uniprot id: A0A452FTA7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102182625
gene id: 9925:LOC102182625
uniprot id: A0A452DUV3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PIANP
gene id: 9925:PIANP
uniprot id: A0A452F0D6
names: Subcellular Location Annotation
messages: Membrane

9925:NPC2
gene id: 9925:NPC2
uniprot id: A0A452F982
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9925:WDYHV1
gene id: 9925:WDYHV1
uniprot id: A0A452DSE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9925:LOC102191766
gene id: 9925:LOC102191766
uniprot id: A0A452DK99
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9925:FAM151A
gene id: 9925:FAM151A
uniprot id: A0A452EIX3
names: Similarity
messages: Belongs to the FAM151 family.

9925:LOC102189098
gene id: 9925:LOC102189098
uniprot id: A0A452E9J0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9925:CTF1
gene id: 9925:CTF1
uniprot id: A0A452ENB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9925:RAP2B
gene id: 9925:RAP2B
uniprot id: A0A452E9E7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9925:SPACA3
gene id: 9925:SPACA3
uniprot id: D7R6C7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Interacts with ASTL.
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.

9925:TUBB
gene id: 9925:TUBB
uniprot id: A0A452G3S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9925:SLC17A9
gene id: 9925:SLC17A9
uniprot id: A0A452FK71
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102177261
gene id: 9925:LOC102177261
uniprot id: A0A452DX67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ARHGEF3
gene id: 9925:ARHGEF3
uniprot id: A0A452ENX5
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9925:CACNG7
gene id: 9925:CACNG7
uniprot id: A0A452F152
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

9925:TRHDE
gene id: 9925:TRHDE
uniprot id: A0A452EA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Membrane

9925:MRPS21
gene id: 9925:MRPS21
uniprot id: A0A452FIR3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9925:PSMC3IP
gene id: 9925:PSMC3IP
uniprot id: A0A452EWI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9925:FABP7
gene id: 9925:FABP7
uniprot id: A0A452FX97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:UBLCP1
gene id: 9925:UBLCP1
uniprot id: A0A452GAJ3
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9925:TIGD7
gene id: 9925:TIGD7
uniprot id: A0A452DRA1
names: Subcellular Location Annotation
messages: Nucleus

9925:SERPINI2
gene id: 9925:SERPINI2
uniprot id: A0A452F5F2
names: Similarity
messages: Belongs to the serpin family.

9925:NMI
gene id: 9925:NMI
uniprot id: A0A452G2A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9925:RNMT
gene id: 9925:RNMT
uniprot id: A0A452DL89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9925:ACTC1
gene id: 9925:ACTC1
uniprot id: A0A452DQU2
names: Similarity
messages: Belongs to the actin family.

9925:MTERF2
gene id: 9925:MTERF2
uniprot id: A0A452EFA0
names: Similarity
messages: Belongs to the mTERF family.

9925:LOC108633258
gene id: 9925:LOC108633258
uniprot id: A0A452EMK2
names: Subcellular Location Annotation
messages: Membrane

9925:ALDH3A2
gene id: 9925:ALDH3A2
uniprot id: A0A452GBL0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:TMED1
gene id: 9925:TMED1
uniprot id: A0A452G856
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9925:NOP56
gene id: 9925:NOP56
uniprot id: A0A452FTT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9925:LOC102183177
gene id: 9925:LOC102183177
uniprot id: A0A452DSF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC108638236
gene id: 9925:LOC108638236
uniprot id: A0A452E7U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102180107
gene id: 9925:LOC102180107
uniprot id: A0A452EAW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC5A11
gene id: 9925:SLC5A11
uniprot id: A0A452FAZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9925:SEC13
gene id: 9925:SEC13
uniprot id: A0A452EQU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

9925:ALAS1
gene id: 9925:ALAS1
uniprot id: A0A452DPU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9925:SPO11
gene id: 9925:SPO11
uniprot id: A0A452FWI4
names: Similarity
messages: Belongs to the TOP6A family.

9925:RPL21
gene id: 9925:RPL21
uniprot id: A5JSS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL21 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: cytosol

9925:SLC46A3
gene id: 9925:SLC46A3
uniprot id: A0A452DSG4
names: Subcellular Location Annotation
messages: Membrane

9925:TDRD3
gene id: 9925:TDRD3
uniprot id: A0A452FBU3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

9925:CDC34
gene id: 9925:CDC34
uniprot id: A0A452G517
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:ADAMTS5
gene id: 9925:ADAMTS5
uniprot id: A0A452F813
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:MOCS3
gene id: 9925:MOCS3
uniprot id: A0A8C2NR00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

9925:ABHD3
gene id: 9925:ABHD3
uniprot id: A0A452FYY9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9925:TUBAL3
gene id: 9925:TUBAL3
uniprot id: A0A452F9S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9925:C16H1orf174
gene id: 9925:C16H1orf174
uniprot id: A0A452FLP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9925:RARG
gene id: 9925:RARG
uniprot id: A0A452FTP1
uniprot id: A0A452FTQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:LOC102177036
gene id: 9925:LOC102177036
uniprot id: A0A452DRN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RNFT2
gene id: 9925:RNFT2
uniprot id: A0A452FNF6
names: Subcellular Location Annotation
messages: Membrane

9925:FERMT1
gene id: 9925:FERMT1
uniprot id: A0A452EZ03
names: Similarity
messages: Belongs to the kindlin family.

9925:LOC102173140
gene id: 9925:LOC102173140
uniprot id: A0A452DSS3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9925:RNF121
gene id: 9925:RNF121
uniprot id: A0A452DUN5
names: Subcellular Location Annotation
messages: Membrane

9925:GK2
gene id: 9925:GK2
uniprot id: A0A452E4Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9925:PPP5C
gene id: 9925:PPP5C
uniprot id: A0A452FYS8
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

9925:FMO2
gene id: 9925:FMO2
uniprot id: A0A452FG45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9925:DNM2
gene id: 9925:DNM2
uniprot id: A0A452G5J8
uniprot id: A0A452G5K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

9925:PRICKLE1
gene id: 9925:PRICKLE1
uniprot id: A0A452ECU1
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9925:SMIM15
gene id: 9925:SMIM15
uniprot id: A0A452DWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9925:RPL32
gene id: 9925:RPL32
uniprot id: A0A452E6T1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9925:LOC102172792
gene id: 9925:LOC102172792
uniprot id: A0A452EUX6
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:FER
gene id: 9925:FER
uniprot id: A0A452EVE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

9925:TELO2
gene id: 9925:TELO2
uniprot id: A0A452EE13
names: Similarity
messages: Belongs to the TEL2 family.

9925:EIF4EBP2
gene id: 9925:EIF4EBP2
uniprot id: A0A452DL71
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9925:PRTFDC1
gene id: 9925:PRTFDC1
uniprot id: A0A452F978
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9925:KCNH1
gene id: 9925:KCNH1
uniprot id: A0A452ELD6
names: Subcellular Location Annotation
messages: Membrane

9925:GATM
gene id: 9925:GATM
uniprot id: A0A452EZU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.
messages: Homodimer.
messages: Mitochondrion inner membrane

9925:LOC108635605
gene id: 9925:LOC108635605
uniprot id: A0A452EDM5
names: Function
messages: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.

9925:SYNDIG1L
gene id: 9925:SYNDIG1L
uniprot id: A0A452F896
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9925:ENY2
gene id: 9925:ENY2
uniprot id: A0A452EVK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9925:PPP1R3B
gene id: 9925:PPP1R3B
uniprot id: A0A452DSS5
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9925:TMEM106A
gene id: 9925:TMEM106A
uniprot id: A0A452DM33
names: Similarity
messages: Belongs to the TMEM106 family.

9925:CAPN2
gene id: 9925:CAPN2
uniprot id: A0A452F4J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9925:TMEM200B
gene id: 9925:TMEM200B
uniprot id: A0A452DRG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9925:PCK2
gene id: 9925:PCK2
uniprot id: A0A452FZ55
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9925:KRT25
gene id: 9925:KRT25
uniprot id: Q6R650
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity).
messages: Heterodimer of a type I and a type II keratin. Heterodimer with type II keratin KRT5 leading to the formation of keratin intermediate filament (KIF) network. Interacts with KRT6A to form filaments.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

9925:AHDC1
gene id: 9925:AHDC1
uniprot id: A0A8C2NFE9
names: Subcellular Location Annotation
messages: Nucleus

9925:ROM1
gene id: 9925:ROM1
uniprot id: A0A452E321
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9925:LOC108638210
gene id: 9925:LOC108638210
uniprot id: A0A452DMD6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ST6GALNAC4
gene id: 9925:ST6GALNAC4
uniprot id: A0A452EEB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:FAM83G
gene id: 9925:FAM83G
uniprot id: A0A452E2W0
names: Similarity
messages: Belongs to the FAM83 family.

9925:ULK1
gene id: 9925:ULK1
uniprot id: A0A452F705
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: Serine/threonine-protein kinase involved in autophagy in response to starvation.

9925:PNPLA1
gene id: 9925:PNPLA1
uniprot id: A0A452FE16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CELF4
gene id: 9925:CELF4
uniprot id: A0A452DTW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9925:FOLR2
gene id: 9925:FOLR2
uniprot id: A0A452EDH0
names: Similarity
messages: Belongs to the folate receptor family.

9925:LOC102184211
gene id: 9925:LOC102184211
uniprot id: A0A452FFG9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9925:FAM20B
gene id: 9925:FAM20B
uniprot id: A0A452ESZ0
names: Similarity
messages: Belongs to the FAM20 family.

9925:RPS27L
gene id: 9925:RPS27L
uniprot id: A0A8C2QSY9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:GAP43
gene id: 9925:GAP43
uniprot id: A0A452F569
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9925:LOC102170232
gene id: 9925:LOC102170232
uniprot id: A0A452F7I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9925:COPS8
gene id: 9925:COPS8
uniprot id: A0A452G9Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9925:MS4A18
gene id: 9925:MS4A18
uniprot id: A0A452EE25
names: Similarity
messages: Belongs to the MS4A family.

9925:SULF1
gene id: 9925:SULF1
uniprot id: A0A452G8Q4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9925:GPR1
gene id: 9925:GPR1
uniprot id: A0A0U2IVY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9925:LOC102185414
gene id: 9925:LOC102185414
uniprot id: A0A452FAU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:KAT6B
gene id: 9925:KAT6B
uniprot id: A0A452DJS0
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

9925:HNRNPUL2
gene id: 9925:HNRNPUL2
uniprot id: A0A452FDC9
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102179937
gene id: 9925:LOC102179937
uniprot id: A0A452EGD3
names: Similarity
messages: Belongs to the MHC class II family.

9925:MB21D2
gene id: 9925:MB21D2
uniprot id: A0A452FG66
names: Similarity
messages: Belongs to the mab-21 family.

9925:SLC6A4
gene id: 9925:SLC6A4
uniprot id: A0A452DQ43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: focal adhesion

9925:ASB8
gene id: 9925:ASB8
uniprot id: A0A452E214
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9925:TGM2
gene id: 9925:TGM2
uniprot id: A0A452G155
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9925:LOC102190981
gene id: 9925:LOC102190981
uniprot id: A0A452G4M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Belongs to the intercrine gamma family.
messages: Secreted

9925:ZYG11B
gene id: 9925:ZYG11B
uniprot id: A0A452DM72
names: Similarity
messages: Belongs to the zyg-11 family.

9925:IKBKB
gene id: 9925:IKBKB
uniprot id: A0A452EKT6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:ESR1
gene id: 9925:ESR1
uniprot id: A0A452EJX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Golgi apparatus
messages: Membrane
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

9925:C7
gene id: 9925:C7
uniprot id: A0A452EW20
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:LOC102181374
gene id: 9925:LOC102181374
uniprot id: A0A452E7P1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9925:GAPVD1
gene id: 9925:GAPVD1
uniprot id: A0A452DTY5
uniprot id: A0A452DUB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9925:DCN
gene id: 9925:DCN
uniprot id: A0A452F311
uniprot id: F2X2Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

9925:TRIM54
gene id: 9925:TRIM54
uniprot id: A0A452EN67
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9925:SIX1
gene id: 9925:SIX1
uniprot id: A0A452G009
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

9925:PRKCD
gene id: 9925:PRKCD
uniprot id: A0A452EQF5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

9925:KCNMB3
gene id: 9925:KCNMB3
uniprot id: A0A452FIZ7
names: Subcellular Location Annotation
messages: Membrane

9925:ACAP3
gene id: 9925:ACAP3
uniprot id: A0A452F2H2
uniprot id: A0A452F314
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9925:OTOP1
gene id: 9925:OTOP1
uniprot id: A0A452FAA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9925:ACO1
gene id: 9925:ACO1
uniprot id: A0A452DUS0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

9925:COQ3
gene id: 9925:COQ3
uniprot id: A0A8C2NTX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9925:ZSCAN26
gene id: 9925:ZSCAN26
uniprot id: A0A452EEV1
names: Subcellular Location Annotation
messages: Nucleus

9925:FGD2
gene id: 9925:FGD2
uniprot id: A0A452GAV1
names: Subcellular Location Annotation
messages: cytoskeleton

9925:ERCC1
gene id: 9925:ERCC1
uniprot id: A0A452G3Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

9925:TIMM44
gene id: 9925:TIMM44
uniprot id: A0A452FXG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

9925:CFAP43
gene id: 9925:CFAP43
uniprot id: A0A452F9F3
names: Similarity
messages: Belongs to the CFAP43 family.

9925:PRND
gene id: 9925:PRND
uniprot id: A7U7P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9925:GLI1
gene id: 9925:GLI1
uniprot id: A0A452DU66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9925:SLCO4C1
gene id: 9925:SLCO4C1
uniprot id: A0A452FQD7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:SLC2A13
gene id: 9925:SLC2A13
uniprot id: A0A452FP08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane

9925:GALR1
gene id: 9925:GALR1
uniprot id: A0A452DKN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9925:RAD23B
gene id: 9925:RAD23B
uniprot id: A0A452FP98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9925:VCP
gene id: 9925:VCP
uniprot id: A0A452F4B6
names: Similarity
messages: Belongs to the AAA ATPase family.

9925:TSPAN13
gene id: 9925:TSPAN13
uniprot id: A0A452EMQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:CSF2
gene id: 9925:CSF2
uniprot id: Q52GZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9925:GPR68
gene id: 9925:GPR68
uniprot id: A0A452E1K6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:PSMB5
gene id: 9925:PSMB5
uniprot id: A0A452E813
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9925:PIAS2
gene id: 9925:PIAS2
uniprot id: A0A452ELK7
uniprot id: A0A452ELT0
names: Similarity
messages: Belongs to the PIAS family.

9925:HOXA10
gene id: 9925:HOXA10
uniprot id: A0A452EMU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:RPL11
gene id: 9925:RPL11
uniprot id: A0A452FE95
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9925:SLC25A22
gene id: 9925:SLC25A22
uniprot id: A0A452EHP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:ELL3
gene id: 9925:ELL3
uniprot id: A0A452EPJ1
uniprot id: A0A8C2RAR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9925:ATG16L2
gene id: 9925:ATG16L2
uniprot id: A0A452DMI3
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9925:HYAL1
gene id: 9925:HYAL1
uniprot id: A0A452FTL3
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9925:CLRN3
gene id: 9925:CLRN3
uniprot id: A0A452EEY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9925:CNP
gene id: 9925:CNP
uniprot id: A0A452DU53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

9925:MAPRE3
gene id: 9925:MAPRE3
uniprot id: A0A452FLU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9925:APIP
gene id: 9925:APIP
uniprot id: A0A452G4N6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9925:LOC102189503
gene id: 9925:LOC102189503
uniprot id: A0A452FKV2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:MUC13
gene id: 9925:MUC13
uniprot id: A0A452DNK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LMNB2
gene id: 9925:LMNB2
uniprot id: A0A452EGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9925:PGM1
gene id: 9925:PGM1
uniprot id: A0A452F6I3
uniprot id: A0A452F6J5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9925:ITGA1
gene id: 9925:ITGA1
uniprot id: A0A452FI09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:LOC102172488
gene id: 9925:LOC102172488
uniprot id: A0A452EW27
names: Similarity
messages: Belongs to the transferrin family.

9925:HTR2A
gene id: 9925:HTR2A
uniprot id: A0A452EXR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

9925:LOC102191560
gene id: 9925:LOC102191560
uniprot id: A0A452E0K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9925:NME4
gene id: 9925:NME4
uniprot id: A0A452FUA1
names: Similarity
messages: Belongs to the NDK family.

9925:FAM53B
gene id: 9925:FAM53B
uniprot id: A0A452EDJ6
names: Similarity
messages: Belongs to the FAM53 family.

9925:ANXA1
gene id: 9925:ANXA1
uniprot id: A0A452FG03
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9925:LIN7C
gene id: 9925:LIN7C
uniprot id: A0A8C2NVT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9925:OSBPL10
gene id: 9925:OSBPL10
uniprot id: A0A452F260
names: Similarity
messages: Belongs to the OSBP family.

9925:NR2F1
gene id: 9925:NR2F1
uniprot id: A0A452E513
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:LOC102170082
gene id: 9925:LOC102170082
uniprot id: A0A452FHP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9925:PSMC2
gene id: 9925:PSMC2
uniprot id: A0A452ER37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9925:RPAP1
gene id: 9925:RPAP1
uniprot id: A0A452FV67
names: Similarity
messages: Belongs to the RPAP1 family.

9925:SPA17
gene id: 9925:SPA17
uniprot id: A0A452FXB5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9925:SAXO1
gene id: 9925:SAXO1
uniprot id: A0A452EQ77
names: Similarity
messages: Belongs to the FAM154 family.

9925:CRCP
gene id: 9925:CRCP
uniprot id: A0A8C2XY05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9925:TMEM132E
gene id: 9925:TMEM132E
uniprot id: A0A452ERS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9925:RSRP1
gene id: 9925:RSRP1
uniprot id: A0A452ER76
names: Similarity
messages: Belongs to the RSRP family.

9925:ATP5G1
gene id: 9925:ATP5G1
uniprot id: A0A452EXR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9925:CALR
gene id: 9925:CALR
uniprot id: A0A452FTJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen
messages: Monomer.

9925:LOC102173405
gene id: 9925:LOC102173405
uniprot id: A0A452E6Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:LOC102178119
gene id: 9925:LOC102178119
uniprot id: A0A452F9Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9925:ITGB7
gene id: 9925:ITGB7
uniprot id: A0A452EQF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9925:KIF5B
gene id: 9925:KIF5B
uniprot id: A0A452F874
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:SIX4
gene id: 9925:SIX4
uniprot id: A0A452EBD2
names: Subcellular Location Annotation
messages: Nucleus

9925:MRPL2
gene id: 9925:MRPL2
uniprot id: A0A452F0F9
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9925:SH3GL2
gene id: 9925:SH3GL2
uniprot id: A0A452FDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9925:SPNS1
gene id: 9925:SPNS1
uniprot id: A0A452F154
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9925:ICOS
gene id: 9925:ICOS
uniprot id: A0A452G0A6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9925:NTN4
gene id: 9925:NTN4
uniprot id: A0A452G946
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ELP6
gene id: 9925:ELP6
uniprot id: A0A8C2SEH4
names: Similarity
messages: Belongs to the ELP6 family.

9925:EMP2
gene id: 9925:EMP2
uniprot id: A0A452E9P4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9925:HSP90AB1
gene id: 9925:HSP90AB1
uniprot id: A0A452F327
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9925:SLC17A6
gene id: 9925:SLC17A6
uniprot id: A0A452F6P1
names: Subcellular Location Annotation
messages: Membrane

9925:RHBDD2
gene id: 9925:RHBDD2
uniprot id: A0A452EL18
uniprot id: A0A8C2S3F3
names: Subcellular Location Annotation
messages: Membrane

9925:MAP3K11
gene id: 9925:MAP3K11
uniprot id: A0A452E300
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9925:UNC93A
gene id: 9925:UNC93A
uniprot id: A0A452FV09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9925:NXPE3
gene id: 9925:NXPE3
uniprot id: A0A452F9G7
names: Similarity
messages: Belongs to the NXPE family.

9925:SSBP3
gene id: 9925:SSBP3
uniprot id: A0A452FW80
uniprot id: A0A452FX13
names: Subcellular Location Annotation
messages: Nucleus

9925:TNFSF13B
gene id: 9925:TNFSF13B
uniprot id: C4NZX0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9925:RTN4
gene id: 9925:RTN4
uniprot id: A0A452DTV6
uniprot id: A0A452DTW0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:KPNB1
gene id: 9925:KPNB1
uniprot id: A0A452EN55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

9925:LIN52
gene id: 9925:LIN52
uniprot id: A0A452FX76
names: Similarity
messages: Belongs to the lin-52 family.

9925:MAPK8
gene id: 9925:MAPK8
uniprot id: A0A452G3A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9925:LOC102179581
gene id: 9925:LOC102179581
uniprot id: A0A452E3S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PDCD4
gene id: 9925:PDCD4
uniprot id: A0A452FM65
uniprot id: A0A452FMX5
names: Similarity
messages: Belongs to the PDCD4 family.

9925:PURG
gene id: 9925:PURG
uniprot id: A0A452FX10
uniprot id: A0A8C2PIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9925:TMEM151B
gene id: 9925:TMEM151B
uniprot id: A0A452FST4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9925:FGF5
gene id: 9925:FGF5
uniprot id: A0A023IMJ9
uniprot id: A0A023IMK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted

9925:TRIP13
gene id: 9925:TRIP13
uniprot id: A0A452FN60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Nucleus
messages: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.
messages: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis.

9925:TNFRSF6B
gene id: 9925:TNFRSF6B
uniprot id: A0A452FVT9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:NUCB1
gene id: 9925:NUCB1
uniprot id: A0A8C2R841
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobindin family.
messages: Cytoplasm
messages: Secreted
messages: cis-Golgi network membrane

9925:GLP1R
gene id: 9925:GLP1R
uniprot id: A0A452FQ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9925:KCNK2
gene id: 9925:KCNK2
uniprot id: A0A452FI40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:S100A4
gene id: 9925:S100A4
uniprot id: A0A452G2G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9925:PDK4
gene id: 9925:PDK4
uniprot id: A0A2Z4FRD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9925:FGD6
gene id: 9925:FGD6
uniprot id: A0A452FDK8
names: Subcellular Location Annotation
messages: cytoskeleton

9925:ACAP1
gene id: 9925:ACAP1
uniprot id: A0A452F248
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9925:ENGASE
gene id: 9925:ENGASE
uniprot id: A0A452F5K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

9925:SFPQ
gene id: 9925:SFPQ
uniprot id: A0A452FRY3
uniprot id: A0A452FS13
names: Subcellular Location Annotation
messages: Nucleus speckle

9925:EML2
gene id: 9925:EML2
uniprot id: A0A452EHH3
uniprot id: A0A452EHR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9925:C10H14orf166
gene id: 9925:C10H14orf166
uniprot id: A0A452F5I1
names: Similarity
messages: Belongs to the RTRAF family.

9925:HSPA9
gene id: 9925:HSPA9
uniprot id: A0A452FBM2
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9925:LOC102190056
gene id: 9925:LOC102190056
uniprot id: A0A452DZR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ATF1
gene id: 9925:ATF1
uniprot id: A0A452EXG9
uniprot id: A0A452EXH3
names: Subcellular Location Annotation
messages: Nucleus

9925:CD3G
gene id: 9925:CD3G
uniprot id: A0A8C2Y1G2
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Membrane
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9925:BCAN
gene id: 9925:BCAN
uniprot id: A0A452E992
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:ZSCAN25
gene id: 9925:ZSCAN25
uniprot id: A0A452FUD6
names: Subcellular Location Annotation
messages: Nucleus

9925:RAD50
gene id: 9925:RAD50
uniprot id: A0A452DTQ1
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9925:VAMP4
gene id: 9925:VAMP4
uniprot id: A0A452G0N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9925:GNRHR
gene id: 9925:GNRHR
uniprot id: A1YZ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

9925:GPHN
gene id: 9925:GPHN
uniprot id: A0A452FVR5
uniprot id: A0A452FWE2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9925:GPR4
gene id: 9925:GPR4
uniprot id: A0A452DRU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:SLC30A2
gene id: 9925:SLC30A2
uniprot id: A0A8C2N8Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9925:TCN2
gene id: 9925:TCN2
uniprot id: A0A452DSJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9925:ASTE1
gene id: 9925:ASTE1
uniprot id: A0A452FK14
names: Similarity
messages: Belongs to the asteroid family.

9925:PARVA
gene id: 9925:PARVA
uniprot id: A0A452G0P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9925:THNSL2
gene id: 9925:THNSL2
uniprot id: A0A452FDG6
names: Similarity
messages: Belongs to the threonine synthase family.

9925:SLC45A2
gene id: 9925:SLC45A2
uniprot id: A0A452FFH3
names: Subcellular Location Annotation
messages: Membrane

9925:EPYC
gene id: 9925:EPYC
uniprot id: A0A452DM63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: extracellular matrix

9925:FAM163B
gene id: 9925:FAM163B
uniprot id: A0A452F2J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9925:CEP170
gene id: 9925:CEP170
uniprot id: A0A452G858
uniprot id: A0A452G8L8
uniprot id: A0A452G8M0
names: Similarity
messages: Belongs to the CEP170 family.

9925:LOC102186104
gene id: 9925:LOC102186104
uniprot id: A0A452DQ40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TM9SF2
gene id: 9925:TM9SF2
uniprot id: A0A452E1Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9925:MYH13
gene id: 9925:MYH13
uniprot id: A0A452E9W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9925:OSBPL9
gene id: 9925:OSBPL9
uniprot id: A0A452G8U1
uniprot id: A0A452G8Y4
names: Similarity
messages: Belongs to the OSBP family.

9925:LDLRAD1
gene id: 9925:LDLRAD1
uniprot id: A0A8C2NR76
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:IMP3
gene id: 9925:IMP3
uniprot id: A0A452DS71
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9925:LLGL2
gene id: 9925:LLGL2
uniprot id: A0A452EH14
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

9925:LOC102182017
gene id: 9925:LOC102182017
uniprot id: A0A452FPT3
names: Subcellular Location Annotation
messages: Membrane

9925:TERT
gene id: 9925:TERT
uniprot id: A0A452DW47
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
messages: The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity.
messages: The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.
messages: The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.
messages: nucleolus
messages: nucleoplasm
messages: telomere

9925:PRKAB1
gene id: 9925:PRKAB1
uniprot id: A0A452FIT0
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9925:YIPF2
gene id: 9925:YIPF2
uniprot id: A0A452EZM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9925:GALNT7
gene id: 9925:GALNT7
uniprot id: A0A452E363
uniprot id: A0A452E387
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:NDST2
gene id: 9925:NDST2
uniprot id: A0A452FKF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9925:LOC102174398
gene id: 9925:LOC102174398
uniprot id: A0A452E5F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9925:APH1B
gene id: 9925:APH1B
uniprot id: A0A452FA75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9925:TMEM218
gene id: 9925:TMEM218
uniprot id: A0A452G323
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9925:RAD51D
gene id: 9925:RAD51D
uniprot id: A0A452FA90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

9925:PAM
gene id: 9925:PAM
uniprot id: A0A452FMY4
uniprot id: A0A452FMZ0
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9925:LZTFL1
gene id: 9925:LZTFL1
uniprot id: A0A452FVB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9925:DNAJC27
gene id: 9925:DNAJC27
uniprot id: A0A452EIN1
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9925:LOC102178318
gene id: 9925:LOC102178318
uniprot id: A0A452DMP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:SLC25A36
gene id: 9925:SLC25A36
uniprot id: A0A452FMP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:FAM13A
gene id: 9925:FAM13A
uniprot id: A0A452EV11
uniprot id: A0A452EV24
names: Similarity
messages: Belongs to the FAM13 family.

9925:KIF26B
gene id: 9925:KIF26B
uniprot id: A0A452G7K3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:TUBA8
gene id: 9925:TUBA8
uniprot id: A0A452FRB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9925:TSPAN31
gene id: 9925:TSPAN31
uniprot id: A0A452EN86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:LOC102176015
gene id: 9925:LOC102176015
uniprot id: A0A452EM54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9925:MGST1
gene id: 9925:MGST1
uniprot id: A0A452EP01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9925:AIF1
gene id: 9925:AIF1
uniprot id: A0A1B1RUY3
uniprot id: A0A452FW36
names: Subcellular Location Annotation
messages: ruffle membrane

9925:IDH3A
gene id: 9925:IDH3A
uniprot id: A0A452EKB7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9925:INCENP
gene id: 9925:INCENP
uniprot id: A0A452FTS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

9925:KCNH3
gene id: 9925:KCNH3
uniprot id: A0A452EHC5
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9925:ONECUT1
gene id: 9925:ONECUT1
uniprot id: A0A452F4S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9925:ST8SIA3
gene id: 9925:ST8SIA3
uniprot id: A0A452FF14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:CAPN1
gene id: 9925:CAPN1
uniprot id: F1DAU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9925:IARS
gene id: 9925:IARS
uniprot id: A0A452FUM9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:HDAC4
gene id: 9925:HDAC4
uniprot id: A0A452F5N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9925:LOC102191315
gene id: 9925:LOC102191315
uniprot id: A0A452ECW5
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:LOC102172282
gene id: 9925:LOC102172282
uniprot id: A0A452E361
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FAM63A
gene id: 9925:FAM63A
uniprot id: A0A452F390
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9925:AFP
gene id: 9925:AFP
uniprot id: A0A452DWC9
names: Subcellular Location Annotation
messages: Secreted

9925:LDB1
gene id: 9925:LDB1
uniprot id: A0A452EB14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB family.
messages: Nucleus

9925:MLEC
gene id: 9925:MLEC
uniprot id: A0A452EL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:COG7
gene id: 9925:COG7
uniprot id: A0A452FES9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:PSMG1
gene id: 9925:PSMG1
uniprot id: A0A452DRV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9925:TMEM170B
gene id: 9925:TMEM170B
uniprot id: A0A452FEH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9925:LEF1
gene id: 9925:LEF1
uniprot id: A0A8C2PKX3
uniprot id: D7RGY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9925:TNIP2
gene id: 9925:TNIP2
uniprot id: A0A452EIM7
names: Subcellular Location Annotation
messages: Cytoplasm

9925:RHPN2
gene id: 9925:RHPN2
uniprot id: A0A452E2S5
names: Similarity
messages: Belongs to the RHPN family.

9925:SPTAN1
gene id: 9925:SPTAN1
uniprot id: A0A452EHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9925:SUPT4H1
gene id: 9925:SUPT4H1
uniprot id: A0A452G929
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9925:ELF3
gene id: 9925:ELF3
uniprot id: A0A452E5R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:SDHAF3
gene id: 9925:SDHAF3
uniprot id: A0A452DY33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9925:EDN3
gene id: 9925:EDN3
uniprot id: A0A452EYV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9925:LOC102173052
gene id: 9925:LOC102173052
uniprot id: A0A452ENA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9925:IL1F10
gene id: 9925:IL1F10
uniprot id: A0A452G7I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9925:IRX3
gene id: 9925:IRX3
uniprot id: A0A452EMX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9925:OXTR
gene id: 9925:OXTR
uniprot id: A0A452DVB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9925:ARRDC2
gene id: 9925:ARRDC2
uniprot id: A0A452DUM9
uniprot id: A0A452DUP0
names: Similarity
messages: Belongs to the arrestin family.

9925:LOC102185949
gene id: 9925:LOC102185949
uniprot id: A0A452E337
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TOP1
gene id: 9925:TOP1
uniprot id: A0A452FWC1
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9925:LOC102179881
gene id: 9925:LOC102179881
uniprot id: E7FKN1
names: Similarity
messages: Belongs to the intermediate filament family.

9925:ILF3
gene id: 9925:ILF3
uniprot id: A0A452FZX1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:RPLP1
gene id: 9925:RPLP1
uniprot id: A0A452E475
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9925:EHD2
gene id: 9925:EHD2
uniprot id: A0A452EA50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9925:PAPPA
gene id: 9925:PAPPA
uniprot id: A0A452EXV0
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:FBLN7
gene id: 9925:FBLN7
uniprot id: A0A452FM07
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:KCNAB1
gene id: 9925:KCNAB1
uniprot id: A0A452FV26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9925:SEMA6B
gene id: 9925:SEMA6B
uniprot id: A0A452G208
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:GABARAP
gene id: 9925:GABARAP
uniprot id: A0A452FI93
names: Similarity
messages: Belongs to the ATG8 family.

9925:IL2RA
gene id: 9925:IL2RA
uniprot id: A0A452E014
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9925:HOXC11
gene id: 9925:HOXC11
uniprot id: A0A452G1W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:ACKR1
gene id: 9925:ACKR1
uniprot id: A0A452DP32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

9925:KDELR1
gene id: 9925:KDELR1
uniprot id: A0A452FJ43
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:DNAJC16
gene id: 9925:DNAJC16
uniprot id: A0A452ESS6
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102183207
gene id: 9925:LOC102183207
uniprot id: A0A452E109
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:PDK1
gene id: 9925:PDK1
uniprot id: A0A452EB53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9925:TRIM36
gene id: 9925:TRIM36
uniprot id: A0A452EZ09
uniprot id: A0A452EZ20
uniprot id: A0A452EZI7
names: Subcellular Location Annotation
messages: cytoskeleton

9925:AK4
gene id: 9925:AK4
uniprot id: A0A452DUP7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9925:TCF25
gene id: 9925:TCF25
uniprot id: A0A452FG39
names: Similarity
messages: Belongs to the TCF25 family.

9925:LOC108633536
gene id: 9925:LOC108633536
uniprot id: A0A452EF96
names: Similarity
messages: Belongs to the serpin family.

9925:SLC30A4
gene id: 9925:SLC30A4
uniprot id: A0A452FFX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9925:PKD2
gene id: 9925:PKD2
uniprot id: A0A452FDG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

9925:TRMT1L
gene id: 9925:TRMT1L
uniprot id: A0A452EW57
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

9925:TRMT6
gene id: 9925:TRMT6
uniprot id: A0A452E3G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9925:PREP
gene id: 9925:PREP
uniprot id: A0A452F941
names: Similarity
messages: Belongs to the peptidase S9A family.

9925:METTL6
gene id: 9925:METTL6
uniprot id: A0A452FI74
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9925:FUT4
gene id: 9925:FUT4
uniprot id: A0A452EGX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9925:CRY2
gene id: 9925:CRY2
uniprot id: A0A452FUT4
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9925:CES4A
gene id: 9925:CES4A
uniprot id: A0A452EW51
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9925:NPPB
gene id: 9925:NPPB
uniprot id: A0A452ER42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.
messages: Secreted

9925:PHC2
gene id: 9925:PHC2
uniprot id: A0A8C2NFZ3
names: Subcellular Location Annotation
messages: Nucleus

9925:SULT1C2
gene id: 9925:SULT1C2
uniprot id: A0A452FGS8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:FBXO34
gene id: 9925:FBXO34
uniprot id: A0A8C2P1J4
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9925:EBF2
gene id: 9925:EBF2
uniprot id: A0A452FUU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9925:SLC25A37
gene id: 9925:SLC25A37
uniprot id: A0A452E0C5
uniprot id: A0A8C2RIU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:WNT7B
gene id: 9925:WNT7B
uniprot id: A0A452ELQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:AJAP1
gene id: 9925:AJAP1
uniprot id: A0A452EVN4
names: Subcellular Location Annotation
messages: Membrane

9925:POLR3C
gene id: 9925:POLR3C
uniprot id: A0A452FNP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9925:DEFB112
gene id: 9925:DEFB112
uniprot id: A0A452DXB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9925:QTRT1
gene id: 9925:QTRT1
uniprot id: A0A452EKD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

9925:LSM4
gene id: 9925:LSM4
uniprot id: A0A8C2QTK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9925:ACVR2B
gene id: 9925:ACVR2B
uniprot id: W8P9F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:TEK
gene id: 9925:TEK
uniprot id: A0A452EJM8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:B3GAT3
gene id: 9925:B3GAT3
uniprot id: A0A452EV34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:ZFHX2
gene id: 9925:ZFHX2
uniprot id: A0A452ERI6
names: Subcellular Location Annotation
messages: Nucleus

9925:ADAM23
gene id: 9925:ADAM23
uniprot id: A0A452E9Q7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:RPL3
gene id: 9925:RPL3
uniprot id: A0A452G2Z1
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9925:LOC102178967
gene id: 9925:LOC102178967
uniprot id: A0A8C2R7P9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9925:LOC108636730
gene id: 9925:LOC108636730
uniprot id: A0A452DVL5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9925:STAT2
gene id: 9925:STAT2
uniprot id: A0A452ET77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9925:GATC
gene id: 9925:GATC
uniprot id: A0A8C2REZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9925:SLC37A3
gene id: 9925:SLC37A3
uniprot id: A0A452DYM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9925:GDF1
gene id: 9925:GDF1
uniprot id: A0A452G8B0
names: Similarity
messages: Belongs to the TGF-beta family.

9925:TACR3
gene id: 9925:TACR3
uniprot id: A0A452FE45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:KRT4
gene id: 9925:KRT4
uniprot id: A0A452G800
names: Similarity
messages: Belongs to the intermediate filament family.

9925:FGF21
gene id: 9925:FGF21
uniprot id: A0A0U2UQ40
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:CYR61
gene id: 9925:CYR61
uniprot id: A0A452GBG4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:LOC102169149
gene id: 9925:LOC102169149
uniprot id: A0A452EDZ4
names: Similarity
messages: Belongs to the S-100 family.

9925:TM4SF19
gene id: 9925:TM4SF19
uniprot id: A0A452EUZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9925:RBCK1
gene id: 9925:RBCK1
uniprot id: A0A452G7S2
names: Similarity
messages: Belongs to the RBR family.

9925:RARA
gene id: 9925:RARA
uniprot id: A0A452EMU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:DENR
gene id: 9925:DENR
uniprot id: A0A452G331
names: Similarity
messages: Belongs to the DENR family.

9925:FGB
gene id: 9925:FGB
uniprot id: A0A452ENA3
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9925:FEN1
gene id: 9925:FEN1
uniprot id: A0A452DZ26
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9925:LOC102171837
gene id: 9925:LOC102171837
uniprot id: A0A8C2NYD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

9925:KCNK18
gene id: 9925:KCNK18
uniprot id: A0A452EIA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:KRT36
gene id: 9925:KRT36
uniprot id: A0A452FUX2
names: Similarity
messages: Belongs to the intermediate filament family.

9925:BCL7A
gene id: 9925:BCL7A
uniprot id: A0A452EY49
names: Similarity
messages: Belongs to the BCL7 family.

9925:PDE3B
gene id: 9925:PDE3B
uniprot id: A0A452E0S6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:TASP1
gene id: 9925:TASP1
uniprot id: A0A452FWZ3
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9925:GDF5
gene id: 9925:GDF5
uniprot id: A0A452ECY9
names: Similarity
messages: Belongs to the TGF-beta family.

9925:FLNC
gene id: 9925:FLNC
uniprot id: A0A452FH25
names: Similarity
messages: Belongs to the filamin family.

9925:LOC102178700
gene id: 9925:LOC102178700
uniprot id: A0A452F3L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9925:LOC102172279
gene id: 9925:LOC102172279
uniprot id: A0A8C2P3D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm

9925:IGF1R
gene id: 9925:IGF1R
uniprot id: A0A452FWJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9925:ZEB1
gene id: 9925:ZEB1
uniprot id: A0A452EVD0
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9925:CNOT6
gene id: 9925:CNOT6
uniprot id: A0A452F7N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9925:LOC102188608
gene id: 9925:LOC102188608
uniprot id: A0A452FJI6
uniprot id: A0A452FJJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted

9925:GRAMD1A
gene id: 9925:GRAMD1A
uniprot id: A0A452FC63
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:CHRNA9
gene id: 9925:CHRNA9
uniprot id: A0A452F076
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:LOC102188506
gene id: 9925:LOC102188506
uniprot id: A0A452F8T9
names: Subcellular Location Annotation
messages: Membrane

9925:RPL18A
gene id: 9925:RPL18A
uniprot id: A0A452G3Q2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9925:LOC102190090
gene id: 9925:LOC102190090
uniprot id: A0A452ENU5
names: Subcellular Location Annotation
messages: Membrane

9925:IRGQ
gene id: 9925:IRGQ
uniprot id: A0A452E2B2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9925:USP33
gene id: 9925:USP33
uniprot id: A0A452EY43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9925:NCSTN
gene id: 9925:NCSTN
uniprot id: A0A452GAX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9925:NELFCD
gene id: 9925:NELFCD
uniprot id: A0A452FK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

9925:PTBP1
gene id: 9925:PTBP1
uniprot id: A0A452F421
uniprot id: A0A8C2S4N7
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102182107
gene id: 9925:LOC102182107
uniprot id: A0A452EG43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SOST
gene id: 9925:SOST
uniprot id: A0A452FBG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the sclerostin family.
messages: Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
messages: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

9925:LETM1
gene id: 9925:LETM1
uniprot id: A0A452F8E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:CACNA2D2
gene id: 9925:CACNA2D2
uniprot id: A0A452EJ87
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9925:NAXE
gene id: 9925:NAXE
uniprot id: A0A452ELA0
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
messages: Homodimer. Interacts with APOA1 and APOA2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

9925:LTA4H
gene id: 9925:LTA4H
uniprot id: A0A452F0G8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9925:AP2A2
gene id: 9925:AP2A2
uniprot id: A0A452G2Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9925:GUCA2A
gene id: 9925:GUCA2A
uniprot id: A0A452DRJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9925:IDH3B
gene id: 9925:IDH3B
uniprot id: A0A452E8M7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9925:KDM4A
gene id: 9925:KDM4A
uniprot id: A0A452EFH6
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9925:SNX14
gene id: 9925:SNX14
uniprot id: A0A452F1Y3
names: Similarity
messages: Belongs to the sorting nexin family.

9925:BMP8B
gene id: 9925:BMP8B
uniprot id: A0A452G135
names: Similarity
messages: Belongs to the TGF-beta family.

9925:ERC1
gene id: 9925:ERC1
uniprot id: A0A452DQI8
uniprot id: A0A452DQK8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:GABRP
gene id: 9925:GABRP
uniprot id: A0A452EG27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:CILP2
gene id: 9925:CILP2
uniprot id: A0A452EW91
names: Subcellular Location Annotation
messages: extracellular matrix

9925:PGM5
gene id: 9925:PGM5
uniprot id: A0A452DT03
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9925:LOC102177596
gene id: 9925:LOC102177596
uniprot id: A0A452DT99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102175598
gene id: 9925:LOC102175598
uniprot id: A0A452EGK9
names: Subcellular Location Annotation
messages: Membrane

9925:FUCA2
gene id: 9925:FUCA2
uniprot id: A0A452FCG0
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9925:LIMK1
gene id: 9925:LIMK1
uniprot id: A0A452GB28
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9925:LIMK2
gene id: 9925:LIMK2
uniprot id: A0A452F3K2
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9925:RPL6
gene id: 9925:RPL6
uniprot id: A0A452EP46
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9925:AP1B1
gene id: 9925:AP1B1
uniprot id: A0A452FHH1
uniprot id: A0A452FHM1
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9925:FAM150A
gene id: 9925:FAM150A
uniprot id: A0A8C2NP60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9925:NUDT19
gene id: 9925:NUDT19
uniprot id: A0A452FJL8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9925:CDK1
gene id: 9925:CDK1
uniprot id: A0A452DKY3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC106501735
gene id: 9925:LOC106501735
uniprot id: A0A452DN87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GUCY1A3
gene id: 9925:GUCY1A3
uniprot id: A0A452EN26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9925:NECAP2
gene id: 9925:NECAP2
uniprot id: A0A452FY48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9925:CCDC85C
gene id: 9925:CCDC85C
uniprot id: A0A452G3R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9925:C17H12orf65
gene id: 9925:C17H12orf65
uniprot id: A0A452FM28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9925:HCRTR2
gene id: 9925:HCRTR2
uniprot id: A0A452DLN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:NPBWR1
gene id: 9925:NPBWR1
uniprot id: A0A452E5M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:CYP19A1
gene id: 9925:CYP19A1
uniprot id: Q6YI21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:SV2B
gene id: 9925:SV2B
uniprot id: A0A452G3Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9925:LOC108636448
gene id: 9925:LOC108636448
uniprot id: A0A452DU27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:KCNN4
gene id: 9925:KCNN4
uniprot id: A0A452F380
names: Subcellular Location Annotation
messages: Membrane

9925:DLX5
gene id: 9925:DLX5
uniprot id: A0A452DYR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9925:CCR6
gene id: 9925:CCR6
uniprot id: A0A452G2R7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:PTGIR
gene id: 9925:PTGIR
uniprot id: A0A452EWA8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:YIPF4
gene id: 9925:YIPF4
uniprot id: A0A452G836
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9925:ATP13A3
gene id: 9925:ATP13A3
uniprot id: A0A452FZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9925:CTSL
gene id: 9925:CTSL
uniprot id: A0A452FFI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9925:LOC102176060
gene id: 9925:LOC102176060
uniprot id: A0A452ECN8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GALNTL5
gene id: 9925:GALNTL5
uniprot id: A0A452F827
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

9925:SMPD2
gene id: 9925:SMPD2
uniprot id: A0A452FP12
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9925:LOC102181844
gene id: 9925:LOC102181844
uniprot id: A0A8C2NEQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC108633414
gene id: 9925:LOC108633414
uniprot id: A0A452E1V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:METTL3
gene id: 9925:METTL3
uniprot id: A0A452EWW0
names: Similarity
messages: Belongs to the MT-A70-like family.

9925:TRIM10
gene id: 9925:TRIM10
uniprot id: A0A8C2PDL0
names: Similarity
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2.

9925:DDR1
gene id: 9925:DDR1
uniprot id: A0A452FK02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9925:PABPC4
gene id: 9925:PABPC4
uniprot id: A0A452F9K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9925:KCNJ5
gene id: 9925:KCNJ5
uniprot id: A0A452EDV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9925:ENDOU
gene id: 9925:ENDOU
uniprot id: A0A452F3I8
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

9925:ALPL
gene id: 9925:ALPL
uniprot id: A0A452EAH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

9925:IPPK
gene id: 9925:IPPK
uniprot id: A0A452DXK2
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9925:DPT
gene id: 9925:DPT
uniprot id: A0A452ELL8
names: Similarity
messages: Belongs to the dermatopontin family.

9925:SF3A1
gene id: 9925:SF3A1
uniprot id: A0A452F5V2
names: Subcellular Location Annotation
messages: Nucleus

9925:MT4
gene id: 9925:MT4
uniprot id: A0A452FU14
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9925:ICAM1
gene id: 9925:ICAM1
uniprot id: A0A452ETY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9925:LOC102190956
gene id: 9925:LOC102190956
uniprot id: A0A452E0I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CES5A
gene id: 9925:CES5A
uniprot id: A0A452FQP6
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9925:ATG16L1
gene id: 9925:ATG16L1
uniprot id: A0A452G7K6
uniprot id: A0A452G7N1
uniprot id: A0A452G7W6
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9925:INHBC
gene id: 9925:INHBC
uniprot id: A0A452F1N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9925:LOC102180142
gene id: 9925:LOC102180142
uniprot id: A0A452DQJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ING1
gene id: 9925:ING1
uniprot id: A0A452FVI7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9925:LOC102180188
gene id: 9925:LOC102180188
uniprot id: A0A452DUF6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102186527
gene id: 9925:LOC102186527
uniprot id: A0A452FTU5
names: Similarity
messages: Belongs to the cystatin family.

9925:PDE6D
gene id: 9925:PDE6D
uniprot id: A0A8C2NE83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9925:RPL8
gene id: 9925:RPL8
uniprot id: A0A452G0W0
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9925:JRKL
gene id: 9925:JRKL
uniprot id: A0A452EFV1
names: Subcellular Location Annotation
messages: Nucleus

9925:FAS
gene id: 9925:FAS
uniprot id: X2KN74
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

9925:LOC102182782
gene id: 9925:LOC102182782
uniprot id: A0A452DXN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:PKN1
gene id: 9925:PKN1
uniprot id: A0A452DZ56
uniprot id: A0A452DZG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Cytoplasm
messages: Midbody
messages: Nucleus

9925:PIGL
gene id: 9925:PIGL
uniprot id: A0A452E715
uniprot id: A0A8C2PAB4
uniprot id: A0A8C2PGY2
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9925:XPA
gene id: 9925:XPA
uniprot id: A0A452E499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9925:TNFAIP2
gene id: 9925:TNFAIP2
uniprot id: A0A452DSY3
names: Similarity
messages: Belongs to the SEC6 family.

9925:LOC102179183
gene id: 9925:LOC102179183
uniprot id: A0A452G2G6
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9925:ZFP36
gene id: 9925:ZFP36
uniprot id: A0A452FS29
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9925:ITGB6
gene id: 9925:ITGB6
uniprot id: A0A452EJ04
uniprot id: J7GY82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9925:TTYH1
gene id: 9925:TTYH1
uniprot id: A0A452EZ17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9925:CTPS1
gene id: 9925:CTPS1
uniprot id: A0A452G8M5
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9925:MYOZ1
gene id: 9925:MYOZ1
uniprot id: A0A452DLN0
names: Similarity
messages: Belongs to the myozenin family.

9925:LOC102182127
gene id: 9925:LOC102182127
uniprot id: A0A452E2Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
messages: Membrane
messages: Microsome
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9925:CHRNA1
gene id: 9925:CHRNA1
uniprot id: A0A452F488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:GSPT1
gene id: 9925:GSPT1
uniprot id: A0A452DZN0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9925:MAP1LC3A
gene id: 9925:MAP1LC3A
uniprot id: A0A452FM01
names: Similarity
messages: Belongs to the ATG8 family.

9925:HSDL2
gene id: 9925:HSDL2
uniprot id: A0A452E1U5
names: Subcellular Location Annotation
messages: Peroxisome

9925:NPEPL1
gene id: 9925:NPEPL1
uniprot id: A0A452FEG1
names: Similarity
messages: Belongs to the peptidase M17 family.

9925:CHRNB1
gene id: 9925:CHRNB1
uniprot id: A0A452ELM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:BTNL9
gene id: 9925:BTNL9
uniprot id: A0A452FRC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9925:CDH6
gene id: 9925:CDH6
uniprot id: A0A452EQP7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:CCR4
gene id: 9925:CCR4
uniprot id: A0A452FBZ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:RGS8
gene id: 9925:RGS8
uniprot id: A0A452DY83
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: Perikaryon
messages: dendrite

9925:MAPKAP1
gene id: 9925:MAPKAP1
uniprot id: A0A452G8W2
names: Similarity
messages: Belongs to the SIN1 family.

9925:SGMS2
gene id: 9925:SGMS2
uniprot id: A0A452F200
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9925:POU3F2
gene id: 9925:POU3F2
uniprot id: A0A452DW31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9925:PARD3
gene id: 9925:PARD3
uniprot id: A0A452F8H2
uniprot id: A0A452F8N4
uniprot id: A0A452F8N8
uniprot id: A0A452F8R7
uniprot id: A0A452F8W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

9925:CD55
gene id: 9925:CD55
uniprot id: A0A452EZB5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:WSCD1
gene id: 9925:WSCD1
uniprot id: A0A452F4I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

9925:GUCY1B3
gene id: 9925:GUCY1B3
uniprot id: A0A452FAW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9925:SCN1B
gene id: 9925:SCN1B
uniprot id: A0A452G6B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon

9925:ESYT2
gene id: 9925:ESYT2
uniprot id: A0A452ED67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:RNPEP
gene id: 9925:RNPEP
uniprot id: A0A452FF60
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9925:TOLLIP
gene id: 9925:TOLLIP
uniprot id: A0A452ECK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9925:TMEM173
gene id: 9925:TMEM173
uniprot id: A0A0M4QBF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9925:HOMER3
gene id: 9925:HOMER3
uniprot id: A0A452EGM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9925:PFDN4
gene id: 9925:PFDN4
uniprot id: A0A452F9W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9925:HINT2
gene id: 9925:HINT2
uniprot id: A0A452E2L2
names: Similarity
messages: Belongs to the HINT family.

9925:KEF96 p04
gene id: 9925:KEF96_p04
uniprot id: D0VEG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion membrane

9925:UBE2I
gene id: 9925:UBE2I
uniprot id: A0A452F1N3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:ARHGEF12
gene id: 9925:ARHGEF12
uniprot id: A0A452G9J3
uniprot id: A0A452G9R8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9925:SH3BP5
gene id: 9925:SH3BP5
uniprot id: A0A452DV05
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9925:TMEM200C
gene id: 9925:TMEM200C
uniprot id: A0A452DQN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9925:CD47
gene id: 9925:CD47
uniprot id: A0A452FPQ8
uniprot id: A0A452FPY5
uniprot id: A0A452FQ27
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:ZRANB2
gene id: 9925:ZRANB2
uniprot id: A0A452E095
uniprot id: A0A452E0B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9925:AQP3
gene id: 9925:AQP3
uniprot id: A0A6C0WYK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9925:MADD
gene id: 9925:MADD
uniprot id: A0A452DQ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9925:RBFOX1
gene id: 9925:RBFOX1
uniprot id: A0A452FUC9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9925:SOSTDC1
gene id: 9925:SOSTDC1
uniprot id: A0A452EBH8
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102180852
gene id: 9925:LOC102180852
uniprot id: A0A452DNB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FRG1
gene id: 9925:FRG1
uniprot id: A0A452E8P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9925:UMOD
gene id: 9925:UMOD
uniprot id: A0A452EQ19
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

9925:LOC102177974
gene id: 9925:LOC102177974
uniprot id: A0A452ECV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ST3GAL6
gene id: 9925:ST3GAL6
uniprot id: A0A452EGP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:TMEM41B
gene id: 9925:TMEM41B
uniprot id: A0A452ETA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9925:LOC102168979
gene id: 9925:LOC102168979
uniprot id: A0A452FTY4
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9925:CHST12
gene id: 9925:CHST12
uniprot id: A0A452DRR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:HECTD1
gene id: 9925:HECTD1
uniprot id: A0A452F3Z6
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

9925:RRN3
gene id: 9925:RRN3
uniprot id: A0A452EP64
names: Similarity
messages: Belongs to the RRN3 family.

9925:C7H19orf53
gene id: 9925:C7H19orf53
uniprot id: A0A452F347
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9925:PACS1
gene id: 9925:PACS1
uniprot id: A0A452FQ37
names: Similarity
messages: Belongs to the PACS family.

9925:WARS2
gene id: 9925:WARS2
uniprot id: A0A452EGV3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:TMEM65
gene id: 9925:TMEM65
uniprot id: A0A452E2Z8
names: Subcellular Location Annotation
messages: Membrane

9925:SRPRB
gene id: 9925:SRPRB
uniprot id: A0A452FB30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:C20H5orf22
gene id: 9925:C20H5orf22
uniprot id: A0A452EFH1
names: Similarity
messages: Belongs to the UPF0489 family.

9925:VKORC1L1
gene id: 9925:VKORC1L1
uniprot id: A0A452G0K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:ATP8B1
gene id: 9925:ATP8B1
uniprot id: A0A452EC68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9925:SRP54
gene id: 9925:SRP54
uniprot id: A0A452G776
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle

9925:RFT1
gene id: 9925:RFT1
uniprot id: A0A452EQ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

9925:FAM234A
gene id: 9925:FAM234A
uniprot id: A0A452DZI2
names: Similarity
messages: Belongs to the FAM234 family.

9925:MRPL4
gene id: 9925:MRPL4
uniprot id: A0A452DLY1
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9925:LOC102179296
gene id: 9925:LOC102179296
uniprot id: A0A452ES58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase IV family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:CASP2
gene id: 9925:CASP2
uniprot id: A0A8C2NEJ0
names: Similarity
messages: Belongs to the peptidase C14A family.

9925:KCNK12
gene id: 9925:KCNK12
uniprot id: A0A452DYM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:PEBP4
gene id: 9925:PEBP4
uniprot id: A0A452F714
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9925:EXOSC9
gene id: 9925:EXOSC9
uniprot id: A0A452F3T8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:VAMP1
gene id: 9925:VAMP1
uniprot id: A0A8C2NDU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9925:LOC102173264
gene id: 9925:LOC102173264
uniprot id: A0A8C2RTV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9925:HMGN3
gene id: 9925:HMGN3
uniprot id: A0A8C2RSB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
messages: Nucleus

9925:GNA15
gene id: 9925:GNA15
uniprot id: A0A452DT67
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9925:SERPINB5
gene id: 9925:SERPINB5
uniprot id: A0A452E653
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

9925:DDO
gene id: 9925:DDO
uniprot id: A0A452DMZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9925:YARS
gene id: 9925:YARS
uniprot id: A0A452EL91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

9925:ZPR1
gene id: 9925:ZPR1
uniprot id: A0A452EKT0
names: Similarity
messages: Belongs to the ZPR1 family.

9925:ADTRP
gene id: 9925:ADTRP
uniprot id: A0A452G3X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9925:ALKBH5
gene id: 9925:ALKBH5
uniprot id: A0A452GBK9
names: Subcellular Location Annotation
names: Subunit
messages: Monomer.
messages: Nucleus speckle

9925:FGF14
gene id: 9925:FGF14
uniprot id: A0A452DPR5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:TCEB1
gene id: 9925:TCEB1
uniprot id: A0A452EPB9
names: Similarity
messages: Belongs to the SKP1 family.

9925:TEX10
gene id: 9925:TEX10
uniprot id: A0A452EE10
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9925:PEX5L
gene id: 9925:PEX5L
uniprot id: A0A452FKC4
uniprot id: A0A452FKV8
uniprot id: A0A8C2RZI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Membrane

9925:LOC102181061
gene id: 9925:LOC102181061
uniprot id: A0A452DWQ7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NKX6-1
gene id: 9925:NKX6-1
uniprot id: A0A452FUR1
names: Subcellular Location Annotation
messages: Nucleus

9925:FABP6
gene id: 9925:FABP6
uniprot id: A0A452EFK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:LOC102174444
gene id: 9925:LOC102174444
uniprot id: A0A452DS61
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9925:NKX2-3
gene id: 9925:NKX2-3
uniprot id: A0A452F1N9
names: Subcellular Location Annotation
messages: Nucleus

9925:NPBWR2
gene id: 9925:NPBWR2
uniprot id: A0A452DQ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:GGCX
gene id: 9925:GGCX
uniprot id: A0A452ENI8
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
messages: Membrane

9925:LOC102190498
gene id: 9925:LOC102190498
uniprot id: A0A452EPL4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9925:SPRTN
gene id: 9925:SPRTN
uniprot id: A0A452EI89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9925:ZDHHC4
gene id: 9925:ZDHHC4
uniprot id: A0A452E6H8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:LOC102191473
gene id: 9925:LOC102191473
uniprot id: A0A452DPU1
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:ZNRD1
gene id: 9925:ZNRD1
uniprot id: A0A452FAI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

9925:RALB
gene id: 9925:RALB
uniprot id: A0A452F8I7
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9925:SLC17A4
gene id: 9925:SLC17A4
uniprot id: A0A452EDE3
uniprot id: A0A452EDR8
names: Subcellular Location Annotation
messages: Membrane

9925:RHOT1
gene id: 9925:RHOT1
uniprot id: A0A452ERV0
uniprot id: A0A452ESX3
uniprot id: A0A452ET91
uniprot id: A0A452ETC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9925:ATL1
gene id: 9925:ATL1
uniprot id: A0A8C2NZ54
uniprot id: A0A8C2P178
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9925:MED10
gene id: 9925:MED10
uniprot id: A0A452FGM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:CDIPT
gene id: 9925:CDIPT
uniprot id: A0A452F8S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9925:LOC102177820
gene id: 9925:LOC102177820
uniprot id: A0A452DQC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:BBS4
gene id: 9925:BBS4
uniprot id: A0A452EPI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

9925:LOC108637118
gene id: 9925:LOC108637118
uniprot id: A0A452E2N3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102188914
gene id: 9925:LOC102188914
uniprot id: A0A452E3X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle
messages: cytosol
messages: trans-Golgi network

9925:NDEL1
gene id: 9925:NDEL1
uniprot id: A0A452FJB8
uniprot id: A0A452FK73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9925:SESN3
gene id: 9925:SESN3
uniprot id: A0A452G353
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9925:LOC102185981
gene id: 9925:LOC102185981
uniprot id: A0A452DPE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9925:MGST2
gene id: 9925:MGST2
uniprot id: A0A452EG75
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9925:ATG12
gene id: 9925:ATG12
uniprot id: A0A452FY60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9925:LOC108636589
gene id: 9925:LOC108636589
uniprot id: A0A8C2NLF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9925:LOC102188409
gene id: 9925:LOC102188409
uniprot id: A0A452E805
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CCDC93
gene id: 9925:CCDC93
uniprot id: A0A452EI87
uniprot id: A0A452EIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC93 family.
messages: Early endosome

9925:TBX6
gene id: 9925:TBX6
uniprot id: A0A452EG45
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:PEPD
gene id: 9925:PEPD
uniprot id: A0A452EQV3
names: Similarity
messages: Belongs to the peptidase M24B family.

9925:PARG
gene id: 9925:PARG
uniprot id: A0A452ET05
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9925:ATF7
gene id: 9925:ATF7
uniprot id: A0A452G4W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.
messages: Nucleus
messages: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening.

9925:PRDM6
gene id: 9925:PRDM6
uniprot id: A0A452G1S6
names: Subcellular Location Annotation
messages: Nucleus

9925:SLC39A3
gene id: 9925:SLC39A3
uniprot id: F4ZW68
names: Subcellular Location Annotation
messages: Membrane

9925:SF3B4
gene id: 9925:SF3B4
uniprot id: A0A452G3X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9925:DGUOK
gene id: 9925:DGUOK
uniprot id: A0A452G177
names: Similarity
messages: Belongs to the DCK/DGK family.

9925:AFM
gene id: 9925:AFM
uniprot id: A0A452FDP5
names: Subcellular Location Annotation
messages: Secreted

9925:TMEM18
gene id: 9925:TMEM18
uniprot id: A0A452GAR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Membrane
messages: Nucleus membrane

9925:PLEKHO1
gene id: 9925:PLEKHO1
uniprot id: A0A452FNE2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:MYADML2
gene id: 9925:MYADML2
uniprot id: A0A452EA22
names: Subcellular Location Annotation
messages: Membrane

9925:SPATA20
gene id: 9925:SPATA20
uniprot id: A0A452EIH3
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

9925:IZUMO3
gene id: 9925:IZUMO3
uniprot id: A0A452F4U9
names: Similarity
messages: Belongs to the Izumo family.

9925:NDUFB6
gene id: 9925:NDUFB6
uniprot id: A0A452GBL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:CKM
gene id: 9925:CKM
uniprot id: A0A452FZ73
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9925:FZD5
gene id: 9925:FZD5
uniprot id: A0A452DUD0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:AKT3
gene id: 9925:AKT3
uniprot id: A0A452G164
uniprot id: A0A452G1K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
messages: Cytoplasm

9925:LOC102191193
gene id: 9925:LOC102191193
uniprot id: A0A452E6M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ITGAL
gene id: 9925:ITGAL
uniprot id: Q32Y13
uniprot id: Q32Y14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:NDUFS5
gene id: 9925:NDUFS5
uniprot id: A0A452EWD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9925:DFNB59
gene id: 9925:DFNB59
uniprot id: A0A452EF15
names: Similarity
messages: Belongs to the gasdermin family.

9925:OSBPL1A
gene id: 9925:OSBPL1A
uniprot id: A0A452DL29
names: Similarity
messages: Belongs to the OSBP family.

9925:GRIA2
gene id: 9925:GRIA2
uniprot id: A0A452EKB0
uniprot id: A0A452EKB5
uniprot id: A0A452EKC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9925:LOC102184244
gene id: 9925:LOC102184244
uniprot id: A0A452DTD1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9925:BCKDK
gene id: 9925:BCKDK
uniprot id: A0A452FNX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9925:IL6ST
gene id: 9925:IL6ST
uniprot id: A0A452DVJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9925:SGF29
gene id: 9925:SGF29
uniprot id: A0A452EQP6
names: Subcellular Location Annotation
messages: Nucleus

9925:TCP1
gene id: 9925:TCP1
uniprot id: A0A452EVX4
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9925:GNG3
gene id: 9925:GNG3
uniprot id: A0A452ET63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:CEP55
gene id: 9925:CEP55
uniprot id: A0A452ES04
names: Subcellular Location Annotation
messages: Cytoplasm

9925:PKNOX2
gene id: 9925:PKNOX2
uniprot id: A0A452FHA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9925:PKM
gene id: 9925:PKM
uniprot id: A0A452ET82
uniprot id: A0A452EU77
names: Similarity
messages: Belongs to the pyruvate kinase family.

9925:BPI
gene id: 9925:BPI
uniprot id: A0A452EUG7
uniprot id: S5U2L5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Cytoplasmic granule membrane
messages: Membrane
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9925:IGF1
gene id: 9925:IGF1
uniprot id: A0A452F6Z4
uniprot id: A0A452F742
uniprot id: D2DS56
uniprot id: P51457
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Expressed in all tissues examined: brain, lung, liver, spleen, uterus, ovary, testis, heart and skeletal muscle.
messages: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).

9925:VAX2
gene id: 9925:VAX2
uniprot id: A0A452E6B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

9925:KCND3
gene id: 9925:KCND3
uniprot id: A0A452F9N6
uniprot id: A0A452F9N9
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9925:MARCH11
gene id: 9925:MARCH11
uniprot id: A0A452F3Y8
names: Subcellular Location Annotation
messages: Membrane

9925:PPP3CA
gene id: 9925:PPP3CA
uniprot id: A0A452G896
uniprot id: A0A452G8C4
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9925:BMP7
gene id: 9925:BMP7
uniprot id: A0A452E223
names: Similarity
messages: Belongs to the TGF-beta family.

9925:CRYAA
gene id: 9925:CRYAA
uniprot id: A0A8C2NM18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9925:CRISP1
gene id: 9925:CRISP1
uniprot id: D6PX60
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:USP24
gene id: 9925:USP24
uniprot id: A0A452FHX9
names: Similarity
messages: Belongs to the peptidase C19 family.

9925:TGFB1
gene id: 9925:TGFB1
uniprot id: G9LQW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

9925:LOC102168925
gene id: 9925:LOC102168925
uniprot id: A0A8C2NQW8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:USP4
gene id: 9925:USP4
uniprot id: A0A452F0Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9925:PHOX2A
gene id: 9925:PHOX2A
uniprot id: A0A452F2B7
names: Subcellular Location Annotation
messages: Nucleus

9925:FAM167A
gene id: 9925:FAM167A
uniprot id: A0A452ESU8
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9925:LOC102191467
gene id: 9925:LOC102191467
uniprot id: A0A452EQE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9925:LOC102168715
gene id: 9925:LOC102168715
uniprot id: A0A452E9G0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ITGB5
gene id: 9925:ITGB5
uniprot id: A0A452EVX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9925:LOC102184291
gene id: 9925:LOC102184291
uniprot id: A0A452E9E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9925:LOC102176290
gene id: 9925:LOC102176290
uniprot id: A0A452EIU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9925:VPS33A
gene id: 9925:VPS33A
uniprot id: A0A452EZQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9925:EXTL3
gene id: 9925:EXTL3
uniprot id: A0A452GBC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:SCNM1
gene id: 9925:SCNM1
uniprot id: A0A452EL07
names: Function
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
messages: nucleoplasm

9925:PLA2G2F
gene id: 9925:PLA2G2F
uniprot id: A0A452EVZ9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9925:IFT43
gene id: 9925:IFT43
uniprot id: A0A452E8L8
names: Similarity
messages: Belongs to the IFT43 family.

9925:LOC102188399
gene id: 9925:LOC102188399
uniprot id: A0A452EBZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TBCA
gene id: 9925:TBCA
uniprot id: A0A452FI28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9925:NXT1
gene id: 9925:NXT1
uniprot id: A0A8C2R5K4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9925:CCBE1
gene id: 9925:CCBE1
uniprot id: A0A452DLM5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102177035
gene id: 9925:LOC102177035
uniprot id: A0A452EC02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DYRK1B
gene id: 9925:DYRK1B
uniprot id: A0A452EJ92
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9925:DYRK1A
gene id: 9925:DYRK1A
uniprot id: A0A452G609
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9925:MCM8
gene id: 9925:MCM8
uniprot id: A0A452ELG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9925:NUPR1
gene id: 9925:NUPR1
uniprot id: A0A452EZY7
names: Similarity
messages: Belongs to the NUPR family.

9925:RPS9
gene id: 9925:RPS9
uniprot id: A0A452FX42
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9925:CEP19
gene id: 9925:CEP19
uniprot id: A0A452FTX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9925:DFNA5
gene id: 9925:DFNA5
uniprot id: A0A452G988
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9925:E2F8
gene id: 9925:E2F8
uniprot id: A0A452FTQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9925:POLA2
gene id: 9925:POLA2
uniprot id: A0A452FJ32
uniprot id: A0A452FJA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

9925:DDX5
gene id: 9925:DDX5
uniprot id: A0A452E9Y3
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9925:LOC108633873
gene id: 9925:LOC108633873
uniprot id: A0A452EFQ5
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

9925:BAC7.5
gene id: 9925:BAC7.5
uniprot id: Q9XSQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9925:LOC102173586
gene id: 9925:LOC102173586
uniprot id: A0A452E4X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MYBBP1A
gene id: 9925:MYBBP1A
uniprot id: A0A452F3T9
names: Similarity
messages: Belongs to the MYBBP1A family.

9925:NFE2L1
gene id: 9925:NFE2L1
uniprot id: A0A452EQK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. CNC subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9925:TTC26
gene id: 9925:TTC26
uniprot id: A0A8C2S9J7
names: Similarity
messages: Belongs to the IFT56 family.

9925:ENPEP
gene id: 9925:ENPEP
uniprot id: A0A452FFI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Membrane
messages: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

9925:NAGPA
gene id: 9925:NAGPA
uniprot id: A0A452FR72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TMEM116
gene id: 9925:TMEM116
uniprot id: A0A8C2RNE3
names: Subcellular Location Annotation
messages: Membrane

9925:ERC2
gene id: 9925:ERC2
uniprot id: A0A452DMV8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:RAB3IL1
gene id: 9925:RAB3IL1
uniprot id: A0A452F3P9
uniprot id: A0A452F3X5
names: Similarity
messages: Belongs to the SEC2 family.

9925:PIGU
gene id: 9925:PIGU
uniprot id: A0A452FZR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:ZDHHC2
gene id: 9925:ZDHHC2
uniprot id: A0A452EBF3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:LOC102191590
gene id: 9925:LOC102191590
uniprot id: A0A452DTI2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:LOC102170373
gene id: 9925:LOC102170373
uniprot id: A0A452FLD6
names: Similarity
messages: Belongs to the serpin family.

9925:SRSF2
gene id: 9925:SRSF2
uniprot id: A0A452EXY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus

9925:TMEM208
gene id: 9925:TMEM208
uniprot id: A0A8C2XRS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9925:NDUFB7
gene id: 9925:NDUFB7
uniprot id: A0A452EGT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9925:HSD17B11
gene id: 9925:HSD17B11
uniprot id: A0A452E9U4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:APOC3
gene id: 9925:APOC3
uniprot id: A0A452EM11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

9925:ORMDL1
gene id: 9925:ORMDL1
uniprot id: A0A452EH98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9925:PDP1
gene id: 9925:PDP1
uniprot id: A0A452FH12
names: Similarity
messages: Belongs to the PP2C family.

9925:TMC5
gene id: 9925:TMC5
uniprot id: A0A452FA18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9925:OSBPL11
gene id: 9925:OSBPL11
uniprot id: A0A452G516
names: Similarity
messages: Belongs to the OSBP family.

9925:AK1
gene id: 9925:AK1
uniprot id: A0A452E712
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

9925:C1H3orf70
gene id: 9925:C1H3orf70
uniprot id: A0A452EZD7
names: Similarity
messages: Belongs to the UPF0524 family.

9925:MFAP1
gene id: 9925:MFAP1
uniprot id: A0A452EIU8
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9925:SEMA4A
gene id: 9925:SEMA4A
uniprot id: A0A452FQ49
names: Similarity
messages: Belongs to the semaphorin family.

9925:FGF11
gene id: 9925:FGF11
uniprot id: A0A452DUH7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:CANT1
gene id: 9925:CANT1
uniprot id: A0A452EYE6
names: Similarity
messages: Belongs to the apyrase family.

9925:TBX21
gene id: 9925:TBX21
uniprot id: A0A452FKU5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:EIF2B5
gene id: 9925:EIF2B5
uniprot id: A0A452G622
uniprot id: A0A8C2RDW7
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

9925:LOC102179792
gene id: 9925:LOC102179792
uniprot id: A0A452DXH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:BMP4
gene id: 9925:BMP4
uniprot id: A0A2Z4FRB3
uniprot id: A6N998
names: Similarity
messages: Belongs to the TGF-beta family.

9925:MAP2K1
gene id: 9925:MAP2K1
uniprot id: A0A452FI55
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:POU3F3
gene id: 9925:POU3F3
uniprot id: A0A452E2B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9925:PSMB10
gene id: 9925:PSMB10
uniprot id: A0A452FTN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9925:PON3
gene id: 9925:PON3
uniprot id: A0A452E7W8
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9925:BFSP1
gene id: 9925:BFSP1
uniprot id: A0A452G3W4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

9925:YWHAH
gene id: 9925:YWHAH
uniprot id: A0A452EU44
names: Similarity
messages: Belongs to the 14-3-3 family.

9925:PIGN
gene id: 9925:PIGN
uniprot id: A0A452FSX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

9925:DDX50
gene id: 9925:DDX50
uniprot id: A0A452DKN8
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9925:SLC29A2
gene id: 9925:SLC29A2
uniprot id: A0A452G130
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9925:ADCK2
gene id: 9925:ADCK2
uniprot id: A0A452G1V7
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9925:THRA
gene id: 9925:THRA
uniprot id: A0A1B0NKT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9925:TTYH2
gene id: 9925:TTYH2
uniprot id: A0A452EL45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9925:CHD6
gene id: 9925:CHD6
uniprot id: A0A452F1D1
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9925:SLC1A6
gene id: 9925:SLC1A6
uniprot id: A0A452E0T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9925:RWDD3
gene id: 9925:RWDD3
uniprot id: A0A452ECB5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:INO80
gene id: 9925:INO80
uniprot id: A0A452E3G3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9925:POLR3A
gene id: 9925:POLR3A
uniprot id: A0A452DLG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9925:LOC102173518
gene id: 9925:LOC102173518
uniprot id: A0A452DUW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC102174708
gene id: 9925:LOC102174708
uniprot id: A0A452DWV8
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9925:LOC102187653
gene id: 9925:LOC102187653
uniprot id: A0A452DPZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RET
gene id: 9925:RET
uniprot id: A0A452FIX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

9925:ANKLE2
gene id: 9925:ANKLE2
uniprot id: A0A452FVA1
names: Similarity
messages: Belongs to the ANKLE2 family.

9925:PAPPA2
gene id: 9925:PAPPA2
uniprot id: A0A452ENN8
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PEX7
gene id: 9925:PEX7
uniprot id: A0A452E8P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

9925:LAMC1
gene id: 9925:LAMC1
uniprot id: A0A452EL69
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9925:GPR158
gene id: 9925:GPR158
uniprot id: A0A452G4I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9925:BSCL2
gene id: 9925:BSCL2
uniprot id: A0A8C2PKL9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:NDUFA10
gene id: 9925:NDUFA10
uniprot id: A0A452ELE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

9925:UBE2G1
gene id: 9925:UBE2G1
uniprot id: A0A8C2RKY8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:BMT2
gene id: 9925:BMT2
uniprot id: A0A452G3E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9925:BROX
gene id: 9925:BROX
uniprot id: A0A452EWX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BROX family.
messages: Membrane

9925:IL6
gene id: 9925:IL6
uniprot id: E3UT57
uniprot id: Q28319
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells.
messages: Secreted

9925:NAA25
gene id: 9925:NAA25
uniprot id: A0A452E523
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

9925:HOXA1
gene id: 9925:HOXA1
uniprot id: A0A452FUM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9925:TM2D3
gene id: 9925:TM2D3
uniprot id: A0A452EWT6
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102190774
gene id: 9925:LOC102190774
uniprot id: A0A452DW50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MRPS33
gene id: 9925:MRPS33
uniprot id: A0A452FUE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9925:C23H6orf89
gene id: 9925:C23H6orf89
uniprot id: A0A452FW45
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9925:FGG
gene id: 9925:FGG
uniprot id: A0A452EM67
uniprot id: A0A452EN73
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9925:FADS3
gene id: 9925:FADS3
uniprot id: A0A452GA92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9925:LOC102176453
gene id: 9925:LOC102176453
uniprot id: A0A452EBV7
names: Similarity
messages: Belongs to the nucleoplasmin family.

9925:YIF1B
gene id: 9925:YIF1B
uniprot id: A0A452EIR8
uniprot id: A0A8C2PJU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9925:POLR2D
gene id: 9925:POLR2D
uniprot id: A0A452G5K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

9925:OCA2
gene id: 9925:OCA2
uniprot id: A0A452G2F2
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102188848
gene id: 9925:LOC102188848
uniprot id: A0A452DWD0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TMED6
gene id: 9925:TMED6
uniprot id: A0A452E4B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LRP6
gene id: 9925:LRP6
uniprot id: A0A452ENK7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:MTAP
gene id: 9925:MTAP
uniprot id: A0A452EN12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9925:LOC102185215
gene id: 9925:LOC102185215
uniprot id: A0A452DQV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:KCNJ4
gene id: 9925:KCNJ4
uniprot id: A0A452DWI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9925:NTRK3
gene id: 9925:NTRK3
uniprot id: A0A452E4R1
uniprot id: A0A452E4V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9925:LGALS3BP
gene id: 9925:LGALS3BP
uniprot id: A0A452FHC8
names: Function
names: Subcellular Location Annotation
messages: Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
messages: extracellular matrix

9925:CD247
gene id: 9925:CD247
uniprot id: A0A452DTN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9925:CCKBR
gene id: 9925:CCKBR
uniprot id: A0A452F475
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:MATK
gene id: 9925:MATK
uniprot id: A0A452ELJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:PRRC1
gene id: 9925:PRRC1
uniprot id: A0A452G8F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

9925:ZDHHC20
gene id: 9925:ZDHHC20
uniprot id: A0A452F7G6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:SMAD1
gene id: 9925:SMAD1
uniprot id: A0A452E7E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9925:NFIX
gene id: 9925:NFIX
uniprot id: A0A452FNB9
uniprot id: A0A452FNC3
uniprot id: A0A452FNF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9925:PSAP
gene id: 9925:PSAP
uniprot id: A0A452DRX5
names: Function
names: Subcellular Location Annotation
messages: Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Secreted

9925:LOC102177871
gene id: 9925:LOC102177871
uniprot id: A0A452DW84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102184086
gene id: 9925:LOC102184086
uniprot id: A0A452DPG9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GCSH
gene id: 9925:GCSH
uniprot id: A0A452E1E4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9925:PRR15
gene id: 9925:PRR15
uniprot id: A0A452E479
names: Similarity
messages: Belongs to the PRR15 family.

9925:GPT2
gene id: 9925:GPT2
uniprot id: A0A452GAD8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9925:MARCKS
gene id: 9925:MARCKS
uniprot id: A0A452E037
names: Similarity
messages: Belongs to the MARCKS family.

9925:KIAA1191
gene id: 9925:KIAA1191
uniprot id: A0A452EIG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9925:LOC102187582
gene id: 9925:LOC102187582
uniprot id: A0A452DYJ3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:EIF3H
gene id: 9925:EIF3H
uniprot id: A0A452E9C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9925:SLC7A11
gene id: 9925:SLC7A11
uniprot id: A0A452DNA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9925:POLG2
gene id: 9925:POLG2
uniprot id: A0A452F0G0
uniprot id: A0A8C2S6A0
names: Subcellular Location Annotation
messages: Mitochondrion

9925:GIP
gene id: 9925:GIP
uniprot id: A0A452E5Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

9925:CHMP4C
gene id: 9925:CHMP4C
uniprot id: A0A452DSF9
names: Similarity
messages: Belongs to the SNF7 family.

9925:CMBL
gene id: 9925:CMBL
uniprot id: A0A452FU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9925:SNX17
gene id: 9925:SNX17
uniprot id: A0A452EBX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9925:GRIA1
gene id: 9925:GRIA1
uniprot id: A0A452EJQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9925:HOXC8
gene id: 9925:HOXC8
uniprot id: A0A1S5UZS7
names: Subcellular Location Annotation
messages: Nucleus

9925:LSM6
gene id: 9925:LSM6
uniprot id: A0A452E3D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9925:PITHD1
gene id: 9925:PITHD1
uniprot id: A0A452E7M6
names: Similarity
messages: Belongs to the PITHD1 family.

9925:WNT8B
gene id: 9925:WNT8B
uniprot id: A0A8C2RUY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:FAM83E
gene id: 9925:FAM83E
uniprot id: A0A452ESU3
names: Similarity
messages: Belongs to the FAM83 family.

9925:CHRNG
gene id: 9925:CHRNG
uniprot id: A0A452EM93
uniprot id: A0A8C2N8S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:SIX6
gene id: 9925:SIX6
uniprot id: A0A452F115
names: Subcellular Location Annotation
messages: Nucleus

9925:MEOX1
gene id: 9925:MEOX1
uniprot id: A0A452ET81
names: Subcellular Location Annotation
messages: Nucleus

9925:PAG-11
gene id: 9925:PAG-11
uniprot id: Q9TTW5
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:LOC102185089
gene id: 9925:LOC102185089
uniprot id: A0A452DNP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC2A4
gene id: 9925:SLC2A4
uniprot id: I0BWM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9925:TM4SF1
gene id: 9925:TM4SF1
uniprot id: A0A452EP11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9925:B3GALT2
gene id: 9925:B3GALT2
uniprot id: A0A452DR82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:MRAP2
gene id: 9925:MRAP2
uniprot id: A0A452DR68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:SETD6
gene id: 9925:SETD6
uniprot id: A0A452DX78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

9925:BAAT
gene id: 9925:BAAT
uniprot id: A0A452G088
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9925:STXBP5
gene id: 9925:STXBP5
uniprot id: A0A452E2M2
uniprot id: A0A452E2M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9925:RRS1
gene id: 9925:RRS1
uniprot id: A0A452DZB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9925:PHKG1
gene id: 9925:PHKG1
uniprot id: A0A452FGA5
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9925:KCNG1
gene id: 9925:KCNG1
uniprot id: A0A452FU51
names: Subcellular Location Annotation
messages: Membrane

9925:MAB21L2
gene id: 9925:MAB21L2
uniprot id: A0A452DUA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

9925:AXIN1
gene id: 9925:AXIN1
uniprot id: A0A452E3B0
uniprot id: A0A452E3D0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9925:SEPT12
gene id: 9925:SEPT12
uniprot id: A0A452EFX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9925:VPS51
gene id: 9925:VPS51
uniprot id: A0A452FZM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Recycling endosome
messages: trans-Golgi network

9925:NANOG
gene id: 9925:NANOG
uniprot id: F8UVM8
uniprot id: I7FNK5
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102180168
gene id: 9925:LOC102180168
uniprot id: A0A452G4F3
names: Similarity
messages: Belongs to the alkaline phosphatase family.

9925:SGSM3
gene id: 9925:SGSM3
uniprot id: A0A452F3M3
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

9925:CHST4
gene id: 9925:CHST4
uniprot id: A0A452DV68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9925:PDGFRA
gene id: 9925:PDGFRA
uniprot id: A0A452DR61
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9925:FGF12
gene id: 9925:FGF12
uniprot id: A0A452EQF3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:TAF5
gene id: 9925:TAF5
uniprot id: A0A8C2R2B2
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9925:SLC30A9
gene id: 9925:SLC30A9
uniprot id: A0A452DTD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Membrane
messages: Nucleus
messages: Vesicle

9925:ALG6
gene id: 9925:ALG6
uniprot id: A0A452F7I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:EHD1
gene id: 9925:EHD1
uniprot id: A0A452FFI1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9925:DIEXF
gene id: 9925:DIEXF
uniprot id: A0A452FK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9925:KANSL2
gene id: 9925:KANSL2
uniprot id: A0A452G6A5
uniprot id: Q861R7
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus
messages: Ubiquitously expressed.

9925:LIAS
gene id: 9925:LIAS
uniprot id: A0A452ENA8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9925:LHX9
gene id: 9925:LHX9
uniprot id: A0A452F3Y4
names: Subcellular Location Annotation
messages: Nucleus

9925:PPA1
gene id: 9925:PPA1
uniprot id: A0A452EUK4
names: Similarity
messages: Belongs to the PPase family.

9925:AGPAT1
gene id: 9925:AGPAT1
uniprot id: A0A452F3L3
uniprot id: A0A8C2S8V7
uniprot id: F8RKS1
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9925:LPAR3
gene id: 9925:LPAR3
uniprot id: A0A452EZM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:SFMBT1
gene id: 9925:SFMBT1
uniprot id: A0A452E4E2
names: Subcellular Location Annotation
messages: Nucleus

9925:HAGH
gene id: 9925:HAGH
uniprot id: A0A452FQ64
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9925:FH
gene id: 9925:FH
uniprot id: A0A452DPJ7
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9925:CASKIN2
gene id: 9925:CASKIN2
uniprot id: A0A452FKC2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9925:ZFYVE26
gene id: 9925:ZFYVE26
uniprot id: A0A452FFB4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.
messages: Midbody
messages: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

9925:SAMD8
gene id: 9925:SAMD8
uniprot id: A0A452EAR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9925:DUSP3
gene id: 9925:DUSP3
uniprot id: A0A452FUN1
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9925:RPL22L1
gene id: 9925:RPL22L1
uniprot id: A0A452E3C0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9925:SOX8
gene id: 9925:SOX8
uniprot id: A0A452EXH6
names: Subcellular Location Annotation
messages: Nucleus

9925:FOXP2
gene id: 9925:FOXP2
uniprot id: A9UCL9
names: Subcellular Location Annotation
messages: Nucleus

9925:CEBPZ
gene id: 9925:CEBPZ
uniprot id: A0A452FFL1
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9925:PTGR2
gene id: 9925:PTGR2
uniprot id: A0A452F5J4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9925:LOC108634231
gene id: 9925:LOC108634231
uniprot id: A0A452DW70
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC102183983
gene id: 9925:LOC102183983
uniprot id: A0A452FS80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:FAHD1
gene id: 9925:FAHD1
uniprot id: A0A8C2RXH2
names: Similarity
messages: Belongs to the FAH family.

9925:LOC102176522
gene id: 9925:LOC102176522
uniprot id: A0A452FQ73
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LOC102176457
gene id: 9925:LOC102176457
uniprot id: A0A452F292
names: Similarity
messages: Belongs to the intermediate filament family.

9925:PREB
gene id: 9925:PREB
uniprot id: A0A452ECP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9925:MB
gene id: 9925:MB
uniprot id: A0A452DWW0
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9925:RPF1
gene id: 9925:RPF1
uniprot id: A0A452ED22
names: Subcellular Location Annotation
messages: nucleolus

9925:EARS2
gene id: 9925:EARS2
uniprot id: A0A452FNV1
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9925:RND3
gene id: 9925:RND3
uniprot id: A0A452FMI5
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9925:FAM168A
gene id: 9925:FAM168A
uniprot id: A0A452G676
uniprot id: A0A8C2QUR5
names: Similarity
messages: Belongs to the FAM168 family.

9925:F2RL2
gene id: 9925:F2RL2
uniprot id: A0A452DN49
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:FNTA
gene id: 9925:FNTA
uniprot id: A0A452E9F5
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9925:PTK2
gene id: 9925:PTK2
uniprot id: A0A452EJE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9925:NARF
gene id: 9925:NARF
uniprot id: A0A452EHS6
names: Similarity
messages: Belongs to the NARF family.

9925:PAX9
gene id: 9925:PAX9
uniprot id: A0A452EZP5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

9925:PLCB3
gene id: 9925:PLCB3
uniprot id: A0A452FAC8
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9925:PDCL3
gene id: 9925:PDCL3
uniprot id: A0A452EGQ3
names: Similarity
messages: Belongs to the phosducin family.

9925:RFNG
gene id: 9925:RFNG
uniprot id: A0A452G5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:CTSA
gene id: 9925:CTSA
uniprot id: A0A452FX35
names: Similarity
messages: Belongs to the peptidase S10 family.

9925:UCHL1
gene id: 9925:UCHL1
uniprot id: A0A452F853
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:MAPRE1
gene id: 9925:MAPRE1
uniprot id: A0A452FST7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

9925:SLITRK3
gene id: 9925:SLITRK3
uniprot id: A0A452DSF0
names: Similarity
messages: Belongs to the SLITRK family.

9925:TMEM206
gene id: 9925:TMEM206
uniprot id: A0A452G5K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9925:TNK2
gene id: 9925:TNK2
uniprot id: A0A452EC95
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus

9925:IRF1
gene id: 9925:IRF1
uniprot id: A0A452FBG6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:DNASE2
gene id: 9925:DNASE2
uniprot id: A0A452F4G7
names: Similarity
messages: Belongs to the DNase II family.

9925:DPP7
gene id: 9925:DPP7
uniprot id: A0A452F4B1
names: Similarity
messages: Belongs to the peptidase S28 family.

9925:PSMA4
gene id: 9925:PSMA4
uniprot id: A0A452EAB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9925:BCL9
gene id: 9925:BCL9
uniprot id: A0A452E221
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9925:PIGZ
gene id: 9925:PIGZ
uniprot id: A0A452FD47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:EOGT
gene id: 9925:EOGT
uniprot id: A0A452EJR1
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9925:ATP5O
gene id: 9925:ATP5O
uniprot id: A0A8C2NCS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9925:TRH
gene id: 9925:TRH
uniprot id: A0A452G1W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9925:LOC102186727
gene id: 9925:LOC102186727
uniprot id: A0A452FMQ6
names: Similarity
messages: Belongs to the MHC class II family.

9925:AGO3
gene id: 9925:AGO3
uniprot id: A0A452E977
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9925:GLI2
gene id: 9925:GLI2
uniprot id: A0A452F0Y2
uniprot id: A0A452F108
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9925:RAX
gene id: 9925:RAX
uniprot id: A0A452ER72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9925:SPIRE1
gene id: 9925:SPIRE1
uniprot id: A0A452E8K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

9925:AMT
gene id: 9925:AMT
uniprot id: A0A452F0W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9925:PIAS1
gene id: 9925:PIAS1
uniprot id: A0A452EJT2
names: Similarity
messages: Belongs to the PIAS family.

9925:TSPAN17
gene id: 9925:TSPAN17
uniprot id: A0A452EPR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:TCP11L2
gene id: 9925:TCP11L2
uniprot id: A0A452EL43
names: Similarity
messages: Belongs to the TCP11 family.

9925:LOC102172084
gene id: 9925:LOC102172084
uniprot id: A0A452FYF4
uniprot id: A0A452FYV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9925:KHDRBS3
gene id: 9925:KHDRBS3
uniprot id: A0A452EW06
names: Similarity
messages: Belongs to the KHDRBS family.

9925:PADI2
gene id: 9925:PADI2
uniprot id: A0A452F1S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9925:3BHSD
gene id: 9925:3BHSD
uniprot id: A0A8C2NC53
uniprot id: A5HEW2
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9925:ODC1
gene id: 9925:ODC1
uniprot id: A0A452GA10
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9925:LOC102174322
gene id: 9925:LOC102174322
uniprot id: A0A452G9E6
names: Similarity
messages: Belongs to the folate receptor family.

9925:DDB1
gene id: 9925:DDB1
uniprot id: A0A452ENH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9925:RPL26
gene id: 9925:RPL26
uniprot id: A0A452G1I8
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9925:ADGRG5
gene id: 9925:ADGRG5
uniprot id: A0A452G708
names: Subcellular Location Annotation
messages: Membrane

9925:CAMK2D
gene id: 9925:CAMK2D
uniprot id: A0A452E1P3
uniprot id: A0A452E1R1
uniprot id: A0A452E1T2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9925:KIF24
gene id: 9925:KIF24
uniprot id: A0A452DZU8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:LOC102181595
gene id: 9925:LOC102181595
uniprot id: A0A452EFB5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Monomer.
messages: Secreted

9925:CLCN7
gene id: 9925:CLCN7
uniprot id: A0A452EUI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9925:NUP58
gene id: 9925:NUP58
uniprot id: A0A452E096
names: Subcellular Location Annotation
messages: nuclear pore complex

9925:TM2D2
gene id: 9925:TM2D2
uniprot id: A0A452FMJ6
names: Subcellular Location Annotation
messages: Membrane

9925:PTP4A3
gene id: 9925:PTP4A3
uniprot id: A0A452DY96
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9925:NDUFAF3
gene id: 9925:NDUFAF3
uniprot id: A0A452FMG6
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9925:NLK
gene id: 9925:NLK
uniprot id: A0A452FQA0
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9925:EXOC2
gene id: 9925:EXOC2
uniprot id: A0A452EG91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9925:UCP2
gene id: 9925:UCP2
uniprot id: A0A452EWK9
uniprot id: H9B8U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:CASP14
gene id: 9925:CASP14
uniprot id: A0A452F7T4
names: Similarity
messages: Belongs to the peptidase C14A family.

9925:ACTL6A
gene id: 9925:ACTL6A
uniprot id: A0A452EY84
names: Similarity
messages: Belongs to the actin family.

9925:SST
gene id: 9925:SST
uniprot id: E2DI30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9925:YWHAB
gene id: 9925:YWHAB
uniprot id: A0A452ETA1
names: Similarity
messages: Belongs to the 14-3-3 family.

9925:GNPAT
gene id: 9925:GNPAT
uniprot id: A0A452EEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9925:CFAP36
gene id: 9925:CFAP36
uniprot id: A0A452DUF5
names: Similarity
messages: Belongs to the CFAP36 family.

9925:PHF19
gene id: 9925:PHF19
uniprot id: A0A452FI57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9925:IFNGR1
gene id: 9925:IFNGR1
uniprot id: A0A452EHZ9
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9925:NT5DC1
gene id: 9925:NT5DC1
uniprot id: A0A452G1E7
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

9925:DUSP4
gene id: 9925:DUSP4
uniprot id: A0A452E7D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9925:SLC52A3
gene id: 9925:SLC52A3
uniprot id: A0A452FFH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9925:CCNYL1
gene id: 9925:CCNYL1
uniprot id: A0A452E6C6
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9925:MVD
gene id: 9925:MVD
uniprot id: A0A452F9A1
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

9925:LOC102186232
gene id: 9925:LOC102186232
uniprot id: A0A8C2PH31
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SEC16B
gene id: 9925:SEC16B
uniprot id: A0A452EJH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

9925:FGF6
gene id: 9925:FGF6
uniprot id: A0A452EHV2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:PIGP
gene id: 9925:PIGP
uniprot id: A0A452DNK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

9925:PSMC6
gene id: 9925:PSMC6
uniprot id: A0A452EZL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9925:JAG1
gene id: 9925:JAG1
uniprot id: A0A452FH50
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9925:SMPDL3A
gene id: 9925:SMPDL3A
uniprot id: A0A452FI06
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9925:LOC102191033
gene id: 9925:LOC102191033
uniprot id: A0A452DUI6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PHYHIPL
gene id: 9925:PHYHIPL
uniprot id: A0A452F6E8
names: Similarity
messages: Belongs to the PHYHIP family.

9925:CCDC103
gene id: 9925:CCDC103
uniprot id: A0A452EPR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9925:SUMO2
gene id: 9925:SUMO2
uniprot id: A0A452G7V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9925:GALT
gene id: 9925:GALT
uniprot id: A0A452G3S3
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9925:GSTK1
gene id: 9925:GSTK1
uniprot id: A0A452FE48
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9925:PROKR1
gene id: 9925:PROKR1
uniprot id: A0A8C2NRN4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:MRPL41
gene id: 9925:MRPL41
uniprot id: A0A452E7R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9925:MKS1
gene id: 9925:MKS1
uniprot id: A0A452FUL1
names: Subcellular Location Annotation
messages: cilium basal body

9925:HSPB2
gene id: 9925:HSPB2
uniprot id: A0A452G4I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9925:GINS3
gene id: 9925:GINS3
uniprot id: A0A452FIC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9925:ADORA1
gene id: 9925:ADORA1
uniprot id: A0A452E2S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9925:PCBD2
gene id: 9925:PCBD2
uniprot id: A0A452FV62
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9925:FOXD2
gene id: 9925:FOXD2
uniprot id: A0A452DM78
names: Subcellular Location Annotation
messages: Nucleus

9925:CDCA8
gene id: 9925:CDCA8
uniprot id: A0A452G8W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9925:LOC102188051
gene id: 9925:LOC102188051
uniprot id: A0A452EHC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:TSN
gene id: 9925:TSN
uniprot id: A0A452E566
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9925:MOGAT1
gene id: 9925:MOGAT1
uniprot id: A0A452DS70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PPIL4
gene id: 9925:PPIL4
uniprot id: A0A452E4I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9925:RHBDD3
gene id: 9925:RHBDD3
uniprot id: A0A452EYQ4
names: Subcellular Location Annotation
messages: Membrane

9925:TUSC5
gene id: 9925:TUSC5
uniprot id: A0A452E447
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9925:TRAP1
gene id: 9925:TRAP1
uniprot id: A0A452FD38
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9925:SENP3
gene id: 9925:SENP3
uniprot id: A0A452EG29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9925:BTG2
gene id: 9925:BTG2
uniprot id: A0A023IYG9
names: Similarity
messages: Belongs to the BTG family.

9925:SLC39A6
gene id: 9925:SLC39A6
uniprot id: A0A452DXW9
names: Subcellular Location Annotation
messages: Membrane

9925:MSI2
gene id: 9925:MSI2
uniprot id: A0A452EW36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm

9925:HACL1
gene id: 9925:HACL1
uniprot id: A0A452EF36
names: Similarity
messages: Belongs to the TPP enzyme family.

9925:MYF5
gene id: 9925:MYF5
uniprot id: G4XMU4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9925:SOX6
gene id: 9925:SOX6
uniprot id: A0A452FKV6
names: Subcellular Location Annotation
messages: Nucleus

9925:RFC2
gene id: 9925:RFC2
uniprot id: A0A452DYI2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9925:SLC13A3
gene id: 9925:SLC13A3
uniprot id: A0A452FZ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9925:ADGRF1
gene id: 9925:ADGRF1
uniprot id: A0A452FZX8
names: Subcellular Location Annotation
messages: Membrane

9925:CHPT1
gene id: 9925:CHPT1
uniprot id: A0A452E218
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9925:SGO1
gene id: 9925:SGO1
uniprot id: A0A452EHY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9925:LOC102181408
gene id: 9925:LOC102181408
uniprot id: A0A452E9X5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:WSCD2
gene id: 9925:WSCD2
uniprot id: A0A452DNE1
names: Similarity
messages: Belongs to the WSCD family.

9925:FADS1
gene id: 9925:FADS1
uniprot id: A0A452FMY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9925:MRPL19
gene id: 9925:MRPL19
uniprot id: A0A452F612
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9925:PTK2B
gene id: 9925:PTK2B
uniprot id: A0A452G6N3
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9925:LOC102187204
gene id: 9925:LOC102187204
uniprot id: A0A452EBG5
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9925:KCNK17
gene id: 9925:KCNK17
uniprot id: A0A452G6G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:LAMP5
gene id: 9925:LAMP5
uniprot id: A0A452EFZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9925:TEKT2
gene id: 9925:TEKT2
uniprot id: A0A452G951
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9925:ACTL7A
gene id: 9925:ACTL7A
uniprot id: A0A452DNE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

9925:MOXD1
gene id: 9925:MOXD1
uniprot id: A0A452F8L9
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9925:NEU1
gene id: 9925:NEU1
uniprot id: A0A452E680
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9925:FOXA2
gene id: 9925:FOXA2
uniprot id: A0A452EIM5
names: Subcellular Location Annotation
messages: Nucleus

9925:CA4
gene id: 9925:CA4
uniprot id: A0A452G7Y5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Interacts with SLC4A4.
messages: Membrane

9925:OSTC
gene id: 9925:OSTC
uniprot id: A0A452ET24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9925:CD151
gene id: 9925:CD151
uniprot id: A0A452DY90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:PLK4
gene id: 9925:PLK4
uniprot id: A0A452FTA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cleavage furrow
messages: centriole

9925:SERPINB1
gene id: 9925:SERPINB1
uniprot id: A0A452F5G1
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9925:KAT5
gene id: 9925:KAT5
uniprot id: A0A452EQH7
uniprot id: A0A452EQJ5
uniprot id: A0A452EQT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9925:MBTPS1
gene id: 9925:MBTPS1
uniprot id: A0A452DNL7
names: Similarity
messages: Belongs to the peptidase S8 family.

9925:TSPAN1
gene id: 9925:TSPAN1
uniprot id: A0A452F483
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:ASL
gene id: 9925:ASL
uniprot id: C6K4R7
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

9925:GALNT5
gene id: 9925:GALNT5
uniprot id: A0A452DMV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:C28H10orf35
gene id: 9925:C28H10orf35
uniprot id: A0A452EKS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9925:TRIP10
gene id: 9925:TRIP10
uniprot id: A0A452FPC7
uniprot id: A0A452FPD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Lysosome
messages: Membrane
messages: cell cortex

9925:CCNY
gene id: 9925:CCNY
uniprot id: A0A452DYC7
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9925:TLR3
gene id: 9925:TLR3
uniprot id: A0A452ESD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9925:SMPDL3B
gene id: 9925:SMPDL3B
uniprot id: A0A452EJJ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9925:HS3ST5
gene id: 9925:HS3ST5
uniprot id: A0A452F9V5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:SUPV3L1
gene id: 9925:SUPV3L1
uniprot id: A0A452DKW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9925:MYO18B
gene id: 9925:MYO18B
uniprot id: A0A452FTW4
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PSMD1
gene id: 9925:PSMD1
uniprot id: A0A452EYN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9925:C15H11orf58
gene id: 9925:C15H11orf58
uniprot id: A0A452FAQ1
names: Similarity
messages: Belongs to the SMAP family.

9925:TMEM126B
gene id: 9925:TMEM126B
uniprot id: A0A452EF70
names: Subcellular Location Annotation
messages: Membrane

9925:DHPS
gene id: 9925:DHPS
uniprot id: A0A452E6I0
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

9925:AES
gene id: 9925:AES
uniprot id: A0A452EEG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9925:MSH4
gene id: 9925:MSH4
uniprot id: A0A452G769
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9925:SNCA
gene id: 9925:SNCA
uniprot id: A0A452EBU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

9925:PSKH1
gene id: 9925:PSKH1
uniprot id: A0A452FPP7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:CMTM2
gene id: 9925:CMTM2
uniprot id: A0A452G158
names: Subcellular Location Annotation
messages: Membrane

9925:LBX2
gene id: 9925:LBX2
uniprot id: A0A452FQB2
names: Subcellular Location Annotation
messages: Nucleus

9925:USP45
gene id: 9925:USP45
uniprot id: A0A452EJ08
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9925:PHC1
gene id: 9925:PHC1
uniprot id: A0A452G295
names: Subcellular Location Annotation
messages: Nucleus

9925:ATG4D
gene id: 9925:ATG4D
uniprot id: A0A452F1U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9925:DNAAF1
gene id: 9925:DNAAF1
uniprot id: A0A452DTY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF1 family.
messages: cilium

9925:SLC1A3
gene id: 9925:SLC1A3
uniprot id: A0A452EY52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9925:PDE8B
gene id: 9925:PDE8B
uniprot id: A0A452FS51
uniprot id: A0A452FS95
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:ADORA3
gene id: 9925:ADORA3
uniprot id: A0A452DXT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9925:LOC102173318
gene id: 9925:LOC102173318
uniprot id: A0A452E3F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:POLD1
gene id: 9925:POLD1
uniprot id: A0A452F6A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9925:BANP
gene id: 9925:BANP
uniprot id: A0A8C2RPT3
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9925:ATP6V0B
gene id: 9925:ATP6V0B
uniprot id: A0A452EZI8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9925:MCTP2
gene id: 9925:MCTP2
uniprot id: A0A452G0T1
uniprot id: A0A452G0U3
names: Subcellular Location Annotation
messages: Membrane

9925:SFMBT2
gene id: 9925:SFMBT2
uniprot id: A0A452EGJ7
names: Subcellular Location Annotation
messages: Nucleus

9925:TMED2
gene id: 9925:TMED2
uniprot id: A0A452EM38
uniprot id: A0A8C2QZJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9925:MIS18A
gene id: 9925:MIS18A
uniprot id: A0A452DXD1
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9925:CFAP45
gene id: 9925:CFAP45
uniprot id: A0A452EXX0
names: Similarity
messages: Belongs to the CFAP45 family.

9925:FRZB
gene id: 9925:FRZB
uniprot id: A0A452FJK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9925:UGP2
gene id: 9925:UGP2
uniprot id: A0A8C2NUG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9925:TMEM59L
gene id: 9925:TMEM59L
uniprot id: A0A452DML0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:MMS19
gene id: 9925:MMS19
uniprot id: A0A452EQB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9925:KIF5A
gene id: 9925:KIF5A
uniprot id: A0A452EPE0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:SLC9A3R1
gene id: 9925:SLC9A3R1
uniprot id: A0A452E5R9
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
messages: filopodium
messages: microvillus
messages: ruffle

9925:HEPHL1
gene id: 9925:HEPHL1
uniprot id: A0A452F969
names: Similarity
messages: Belongs to the multicopper oxidase family.

9925:LOC102179973
gene id: 9925:LOC102179973
uniprot id: A0A452FTP7
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9925:LOC102180750
gene id: 9925:LOC102180750
uniprot id: A0A452DV13
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ANTXR1
gene id: 9925:ANTXR1
uniprot id: A0A452FTU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9925:LOC106503078
gene id: 9925:LOC106503078
uniprot id: A0A452EW59
names: Similarity
messages: Belongs to the GcvT family.

9925:CXXC5
gene id: 9925:CXXC5
uniprot id: A0A452F2Q3
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LEO1
gene id: 9925:LEO1
uniprot id: A0A452EKI6
names: Similarity
messages: Belongs to the LEO1 family.

9925:LOC102168677
gene id: 9925:LOC102168677
uniprot id: A0A452E3U7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9925:INTS2
gene id: 9925:INTS2
uniprot id: A0A452G1R0
names: Similarity
messages: Belongs to the Integrator subunit 2 family.

9925:SLC5A9
gene id: 9925:SLC5A9
uniprot id: A0A452DWV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9925:RIBC2
gene id: 9925:RIBC2
uniprot id: A0A452F7L7
names: Similarity
messages: Belongs to the RIB43A family.

9925:TBXA2R
gene id: 9925:TBXA2R
uniprot id: A0A452EDL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:LOC102169702
gene id: 9925:LOC102169702
uniprot id: A0A452F5Z1
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102177548
gene id: 9925:LOC102177548
uniprot id: A0A452E1J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RAD23A
gene id: 9925:RAD23A
uniprot id: A0A452F148
uniprot id: A0A8C2SMC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9925:NUP98
gene id: 9925:NUP98
uniprot id: A0A452EVV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

9925:HDAC1
gene id: 9925:HDAC1
uniprot id: A0A8C2P5Y0
uniprot id: A0A8C2QWI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

9925:LOC102171189
gene id: 9925:LOC102171189
uniprot id: A0A452DTE0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9925:STAM
gene id: 9925:STAM
uniprot id: A0A452DQV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9925:PMP22
gene id: 9925:PMP22
uniprot id: A0A452E2E7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

9925:CHDH
gene id: 9925:CHDH
uniprot id: A0A452E2A6
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

9925:ARHGDIG
gene id: 9925:ARHGDIG
uniprot id: A0A452G500
names: Similarity
messages: Belongs to the Rho GDI family.

9925:LAMTOR2
gene id: 9925:LAMTOR2
uniprot id: A0A452G7R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9925:MFGE8
gene id: 9925:MFGE8
uniprot id: A0A452EH90
uniprot id: C7FDJ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SPICE1
gene id: 9925:SPICE1
uniprot id: A0A452EVC4
uniprot id: A0A452EVG8
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

9925:MTURN
gene id: 9925:MTURN
uniprot id: A0A452EB04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm

9925:HAPLN2
gene id: 9925:HAPLN2
uniprot id: A0A452G2N9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:TNRC6A
gene id: 9925:TNRC6A
uniprot id: A0A452F9Z0
names: Similarity
messages: Belongs to the GW182 family.

9925:IL1RAP
gene id: 9925:IL1RAP
uniprot id: A0A452F0J7
uniprot id: A0A452F0V2
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9925:PCMTD1
gene id: 9925:PCMTD1
uniprot id: A0A452FXB4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9925:UBE2E3
gene id: 9925:UBE2E3
uniprot id: A0A452E067
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:LOC102188471
gene id: 9925:LOC102188471
uniprot id: A0A452F848
names: Similarity
messages: Belongs to the CSN9 family.

9925:SHMT1
gene id: 9925:SHMT1
uniprot id: A0A452EH27
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9925:PCSK1
gene id: 9925:PCSK1
uniprot id: A0A452E007
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9925:CAMTA2
gene id: 9925:CAMTA2
uniprot id: A0A452E726
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

9925:HGF
gene id: 9925:HGF
uniprot id: A0A452E0H7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9925:STAT3
gene id: 9925:STAT3
uniprot id: A0A0G3VSP3
uniprot id: A0A452FDR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9925:NME5
gene id: 9925:NME5
uniprot id: A0A452EME5
names: Similarity
messages: Belongs to the NDK family.

9925:LOC102169002
gene id: 9925:LOC102169002
uniprot id: A0A452EEV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:CLUAP1
gene id: 9925:CLUAP1
uniprot id: A0A452FMQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9925:NOTCH2
gene id: 9925:NOTCH2
uniprot id: A0A452FP76
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9925:KRT19
gene id: 9925:KRT19
uniprot id: A0A452FYB3
names: Similarity
messages: Belongs to the intermediate filament family.

9925:ANO8
gene id: 9925:ANO8
uniprot id: A0A452F9R1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:HS3ST2
gene id: 9925:HS3ST2
uniprot id: A0A452DR26
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:LOC102170459
gene id: 9925:LOC102170459
uniprot id: A0A452G0A7
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9925:NUDT12
gene id: 9925:NUDT12
uniprot id: A0A452FUS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9925:HSPA4
gene id: 9925:HSPA4
uniprot id: A0A452DZT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9925:GET4
gene id: 9925:GET4
uniprot id: A0A452FKG7
names: Similarity
messages: Belongs to the GET4 family.

9925:LOC102188532
gene id: 9925:LOC102188532
uniprot id: A0A8C2NF97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC7A14
gene id: 9925:SLC7A14
uniprot id: A0A452F055
names: Subcellular Location Annotation
messages: Membrane

9925:PROM2
gene id: 9925:PROM2
uniprot id: A0A452F3X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9925:SAP130
gene id: 9925:SAP130
uniprot id: A0A452F9G3
uniprot id: A0A452F9K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9925:LOC102179376
gene id: 9925:LOC102179376
uniprot id: A0A452DVX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:HACD3
gene id: 9925:HACD3
uniprot id: A0A8C2PF29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:DTX2
gene id: 9925:DTX2
uniprot id: A0A452EIN4
uniprot id: A0A452EIP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9925:TGM5
gene id: 9925:TGM5
uniprot id: A0A452EPE1
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9925:CTSV
gene id: 9925:CTSV
uniprot id: A0A452DXP3
uniprot id: W8NX99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9925:MAP2K6
gene id: 9925:MAP2K6
uniprot id: A0A452FY29
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:TBX20
gene id: 9925:TBX20
uniprot id: A0A452E768
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:MYO1D
gene id: 9925:MYO1D
uniprot id: A0A452EPI6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:FZD10
gene id: 9925:FZD10
uniprot id: A0A452DWU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9925:B3GAT2
gene id: 9925:B3GAT2
uniprot id: A0A452F542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:MYO9A
gene id: 9925:MYO9A
uniprot id: A0A452E983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Membrane
messages: Synapse
messages: growth cone

9925:PLD1
gene id: 9925:PLD1
uniprot id: A0A452E2A1
uniprot id: A0A452E2C3
uniprot id: A0A452E2F5
names: Similarity
messages: Belongs to the phospholipase D family.

9925:FOXO6
gene id: 9925:FOXO6
uniprot id: A0A452F431
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC108633231
gene id: 9925:LOC108633231
uniprot id: A0A452G4S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9925:E2F5
gene id: 9925:E2F5
uniprot id: A0A452EDR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9925:YRDC
gene id: 9925:YRDC
uniprot id: A0A452DV91
names: Similarity
messages: Belongs to the SUA5 family.

9925:DLX4
gene id: 9925:DLX4
uniprot id: A0A452E643
names: Subcellular Location Annotation
messages: Nucleus

9925:ZNF18
gene id: 9925:ZNF18
uniprot id: A0A452EAE7
names: Subcellular Location Annotation
messages: Nucleus

9925:SRD5A1
gene id: 9925:SRD5A1
uniprot id: A0A452EAN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9925:PDE9A
gene id: 9925:PDE9A
uniprot id: A0A452F0L5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:CWF19L1
gene id: 9925:CWF19L1
uniprot id: A0A452FN82
names: Similarity
messages: Belongs to the CWF19 family.

9925:KDELC2
gene id: 9925:KDELC2
uniprot id: A0A452FHJ0
names: Similarity
messages: Belongs to the KDELC family.

9925:DUSP6
gene id: 9925:DUSP6
uniprot id: A0A452E7K9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9925:LOC102181854
gene id: 9925:LOC102181854
uniprot id: A0A452EPX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9925:ATP12A
gene id: 9925:ATP12A
uniprot id: A0A452FSL1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:B3GALNT2
gene id: 9925:B3GALNT2
uniprot id: A0A452E5J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:STMN2
gene id: 9925:STMN2
uniprot id: A0A452EK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Membrane
messages: lamellipodium

9925:TEF
gene id: 9925:TEF
uniprot id: A0A452ESX6
uniprot id: A0A452EU33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9925:BARHL2
gene id: 9925:BARHL2
uniprot id: A0A452E9V5
names: Subcellular Location Annotation
messages: Nucleus

9925:DSG4
gene id: 9925:DSG4
uniprot id: A0A097ITJ2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9925:TBRG1
gene id: 9925:TBRG1
uniprot id: A0A452FEF0
names: Subcellular Location Annotation
messages: Nucleus

9925:PEX12
gene id: 9925:PEX12
uniprot id: A0A452G3U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

9925:C6
gene id: 9925:C6
uniprot id: A0A452FI89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:RPL5
gene id: 9925:RPL5
uniprot id: A0A452EQ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9925:LOC102185049
gene id: 9925:LOC102185049
uniprot id: A0A452DR58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:COQ9
gene id: 9925:COQ9
uniprot id: A0A452EXH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9925:FOXA3
gene id: 9925:FOXA3
uniprot id: A0A452E753
names: Subcellular Location Annotation
messages: Nucleus

9925:JUNB
gene id: 9925:JUNB
uniprot id: A0A452DVD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9925:GMPR2
gene id: 9925:GMPR2
uniprot id: A0A452E631
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9925:TNS2
gene id: 9925:TNS2
uniprot id: A0A452DSA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9925:TLR4
gene id: 9925:TLR4
uniprot id: E5FXB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9925:POLM
gene id: 9925:POLM
uniprot id: A0A452FQR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9925:NSUN5
gene id: 9925:NSUN5
uniprot id: A0A452EAS7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9925:OXR1
gene id: 9925:OXR1
uniprot id: A0A452FE32
names: Similarity
messages: Belongs to the OXR1 family.

9925:NKAIN1
gene id: 9925:NKAIN1
uniprot id: A0A452G801
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9925:LITAF
gene id: 9925:LITAF
uniprot id: A0A452EJQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9925:TNKS
gene id: 9925:TNKS
uniprot id: A0A452DWE3
names: Function
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9925:KCNK4
gene id: 9925:KCNK4
uniprot id: A0A8C2PHT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:FOXL1
gene id: 9925:FOXL1
uniprot id: A0A452DP17
names: Subcellular Location Annotation
messages: Nucleus

9925:MRPS30
gene id: 9925:MRPS30
uniprot id: A0A452F664
names: Subcellular Location Annotation
messages: Mitochondrion

9925:MOCS1
gene id: 9925:MOCS1
uniprot id: A0A452E0P0
uniprot id: A0A452E0S3
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9925:VCAN
gene id: 9925:VCAN
uniprot id: A0A452G5Y3
uniprot id: A0A452G645
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:ATP4A
gene id: 9925:ATP4A
uniprot id: A0A452FAW7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9925:NCAPD3
gene id: 9925:NCAPD3
uniprot id: A0A452FGS3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

9925:SLC27A6
gene id: 9925:SLC27A6
uniprot id: A0A452FZ59
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:FMO5
gene id: 9925:FMO5
uniprot id: A0A452EK71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9925:MYH8
gene id: 9925:MYH8
uniprot id: A0A452E4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9925:PPM1A
gene id: 9925:PPM1A
uniprot id: A0A452FPD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9925:KIAA1147
gene id: 9925:KIAA1147
uniprot id: A0A452ES34
names: Similarity
messages: Belongs to the DENND11 family.

9925:YWHAZ
gene id: 9925:YWHAZ
uniprot id: A0A097C2Z1
names: Similarity
messages: Belongs to the 14-3-3 family.

9925:C7H5orf63
gene id: 9925:C7H5orf63
uniprot id: A0A452FT28
names: Similarity
messages: Belongs to the glutaredoxin family.

9925:BABAM1
gene id: 9925:BABAM1
uniprot id: A0A452G0F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9925:XPR1
gene id: 9925:XPR1
uniprot id: A0A452FUT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

9925:SNX11
gene id: 9925:SNX11
uniprot id: A0A452F0R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9925:ALG10
gene id: 9925:ALG10
uniprot id: A0A452FT10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Membrane

9925:TAGLN
gene id: 9925:TAGLN
uniprot id: A0A452EMK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

9925:NEFL
gene id: 9925:NEFL
uniprot id: A0A452EA90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: cytoskeleton

9925:BECN1
gene id: 9925:BECN1
uniprot id: A0A452FIW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9925:NDST3
gene id: 9925:NDST3
uniprot id: A0A452ESG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9925:POU6F1
gene id: 9925:POU6F1
uniprot id: A0A452G7A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9925:IGFBP4
gene id: 9925:IGFBP4
uniprot id: B2CZF1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:ATP6V0E2
gene id: 9925:ATP6V0E2
uniprot id: A0A8C2PE74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane

9925:TPM4
gene id: 9925:TPM4
uniprot id: A0A452E083
uniprot id: A0A452E0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9925:GMPPA
gene id: 9925:GMPPA
uniprot id: A0A452EZM7
uniprot id: A0A452EZZ7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9925:FIGNL1
gene id: 9925:FIGNL1
uniprot id: A0A452DRX8
names: Similarity
messages: Belongs to the AAA ATPase family.

9925:ETFRF1
gene id: 9925:ETFRF1
uniprot id: A0A452FRN9
names: Similarity
messages: Belongs to the complex I LYR family.

9925:GNAL
gene id: 9925:GNAL
uniprot id: A0A452FIN5
uniprot id: A0A8C2P7G8
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9925:CCNO
gene id: 9925:CCNO
uniprot id: A0A452EYZ6
names: Similarity
messages: Belongs to the cyclin family.

9925:TYW3
gene id: 9925:TYW3
uniprot id: A0A452E023
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9925:LOC102183616
gene id: 9925:LOC102183616
uniprot id: A0A452EHX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9925:LOC102190216
gene id: 9925:LOC102190216
uniprot id: A0A452ECT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LGR4
gene id: 9925:LGR4
uniprot id: A0A452GBH5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:SPON1
gene id: 9925:SPON1
uniprot id: A0A452FYE2
names: Subcellular Location Annotation
messages: extracellular matrix

9925:GLDN
gene id: 9925:GLDN
uniprot id: A0A452G4C1
uniprot id: A0A452G4C6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TTLL1
gene id: 9925:TTLL1
uniprot id: A0A452ERA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin polyglutamylase family.
messages: cilium basal body

9925:MELK
gene id: 9925:MELK
uniprot id: A0A452G6D5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9925:PTCD2
gene id: 9925:PTCD2
uniprot id: A0A452EYJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

9925:UCN2
gene id: 9925:UCN2
uniprot id: A0A452DTN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9925:TMPRSS3
gene id: 9925:TMPRSS3
uniprot id: A0A452E3P5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102186759
gene id: 9925:LOC102186759
uniprot id: A0A452G8F3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:ANAPC15
gene id: 9925:ANAPC15
uniprot id: A0A8C2P531
names: Similarity
messages: Belongs to the APC15 family.

9925:PATL1
gene id: 9925:PATL1
uniprot id: A0A452G530
names: Similarity
messages: Belongs to the PAT1 family.

9925:LOC102181615
gene id: 9925:LOC102181615
uniprot id: A0A452DNV0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102184416
gene id: 9925:LOC102184416
uniprot id: A0A452DZL7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MRPS12
gene id: 9925:MRPS12
uniprot id: A0A452EIR2
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9925:NCDN
gene id: 9925:NCDN
uniprot id: A0A452G7Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

9925:ENTPD6
gene id: 9925:ENTPD6
uniprot id: A0A452EFY1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9925:LGI4
gene id: 9925:LGI4
uniprot id: A0A452DRW0
names: Subcellular Location Annotation
messages: Secreted

9925:LOC102174842
gene id: 9925:LOC102174842
uniprot id: A0A452DZP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:LIN9
gene id: 9925:LIN9
uniprot id: A0A452DP75
names: Similarity
messages: Belongs to the lin-9 family.

9925:PATJ
gene id: 9925:PATJ
uniprot id: A0A452FUY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: tight junction

9925:TADA3
gene id: 9925:TADA3
uniprot id: A0A452EBR0
uniprot id: A0A8C2RA82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9925:NCBP2
gene id: 9925:NCBP2
uniprot id: A0A452G489
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9925:GAB2
gene id: 9925:GAB2
uniprot id: A0A452F0U2
names: Similarity
messages: Belongs to the GAB family.

9925:GPR137B
gene id: 9925:GPR137B
uniprot id: A0A8C2Y4M0
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9925:TDRD5
gene id: 9925:TDRD5
uniprot id: A0A452G9R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.

9925:LOC102188675
gene id: 9925:LOC102188675
uniprot id: A0A452ETY1
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9925:MRPS11
gene id: 9925:MRPS11
uniprot id: A0A452FKV0
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9925:PARP9
gene id: 9925:PARP9
uniprot id: A0A452ETJ6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9925:APOA5
gene id: 9925:APOA5
uniprot id: A0A452DW00
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9925:GTF2IRD1
gene id: 9925:GTF2IRD1
uniprot id: A0A452FC07
uniprot id: A0A452FC49
uniprot id: A0A452FCM0
names: Subcellular Location Annotation
messages: Nucleus

9925:SLC34A2
gene id: 9925:SLC34A2
uniprot id: A0A452ERT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport.
messages: Membrane

9925:ADAMTS3
gene id: 9925:ADAMTS3
uniprot id: A0A452DX42
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:RER1
gene id: 9925:RER1
uniprot id: A0A452DVN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9925:GOT2
gene id: 9925:GOT2
uniprot id: A0A452EG24
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9925:LARP7
gene id: 9925:LARP7
uniprot id: A0A452EJW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LARP7 family.
messages: nucleoplasm

9925:LOC102188597
gene id: 9925:LOC102188597
uniprot id: A0A452DUC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FABP2
gene id: 9925:FABP2
uniprot id: K9LRP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9925:PGP
gene id: 9925:PGP
uniprot id: A0A452EJU5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9925:CDC20
gene id: 9925:CDC20
uniprot id: A0A452FC83
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9925:LOC102190950
gene id: 9925:LOC102190950
uniprot id: A0A452DWL3
names: Similarity
messages: Belongs to the NSG family.

9925:PPFIBP2
gene id: 9925:PPFIBP2
uniprot id: A0A452FFD8
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9925:RNGTT
gene id: 9925:RNGTT
uniprot id: A0A452F5W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9925:DPCD
gene id: 9925:DPCD
uniprot id: A0A452FFY8
names: Similarity
messages: Belongs to the DPCD family.

9925:SLC13A1
gene id: 9925:SLC13A1
uniprot id: A0A452ELR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9925:TSC22D1
gene id: 9925:TSC22D1
uniprot id: A0A452EBM0
uniprot id: A0A452EC52
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9925:LIN54
gene id: 9925:LIN54
uniprot id: A0A452FZZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9925:SLC25A35
gene id: 9925:SLC25A35
uniprot id: A0A8C2S5V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:SLC25A33
gene id: 9925:SLC25A33
uniprot id: A0A452EHP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:MRPL34
gene id: 9925:MRPL34
uniprot id: A0A452EKH1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

9925:COG2
gene id: 9925:COG2
uniprot id: A0A452DTR1
names: Similarity
messages: Belongs to the COG2 family.

9925:LOC102177091
gene id: 9925:LOC102177091
uniprot id: A0A452EGZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9925:MRPS10
gene id: 9925:MRPS10
uniprot id: A0A452FQR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9925:ALDH1A1
gene id: 9925:ALDH1A1
uniprot id: A0A452F2N3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:ITGA5
gene id: 9925:ITGA5
uniprot id: A0A452EMC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:LOC102188049
gene id: 9925:LOC102188049
uniprot id: A0A452DSH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:OPN5
gene id: 9925:OPN5
uniprot id: A0A452FM79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9925:TMBIM4
gene id: 9925:TMBIM4
uniprot id: A0A452FHZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9925:IL37
gene id: 9925:IL37
uniprot id: A0A452DPS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9925:MMP8
gene id: 9925:MMP8
uniprot id: A0A452G9V8
names: Similarity
messages: Belongs to the peptidase M10A family.

9925:LOC102182848
gene id: 9925:LOC102182848
uniprot id: A0A452DT02
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC102184368
gene id: 9925:LOC102184368
uniprot id: A0A452E2X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SMG9
gene id: 9925:SMG9
uniprot id: A0A452FM24
names: Similarity
messages: Belongs to the SMG9 family.

9925:SCAMP3
gene id: 9925:SCAMP3
uniprot id: A0A452DRK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9925:SLC16A5
gene id: 9925:SLC16A5
uniprot id: A0A452F4T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9925:CADM3
gene id: 9925:CADM3
uniprot id: A0A452DZM8
uniprot id: A0A452DZX3
names: Similarity
messages: Belongs to the nectin family.

9925:TES
gene id: 9925:TES
uniprot id: A0A452G6C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.
messages: focal adhesion

9925:HOXB1
gene id: 9925:HOXB1
uniprot id: A0A452F2F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9925:MCEE
gene id: 9925:MCEE
uniprot id: A0A452FD94
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9925:KCNA1
gene id: 9925:KCNA1
uniprot id: A0A452DP60
names: Subcellular Location Annotation
messages: Membrane

9925:HAL
gene id: 9925:HAL
uniprot id: A0A452F7N4
names: Similarity
messages: Belongs to the PAL/histidase family.

9925:ATXN2L
gene id: 9925:ATXN2L
uniprot id: A0A452E1V5
names: Similarity
messages: Belongs to the ataxin-2 family.

9925:SYNGR4
gene id: 9925:SYNGR4
uniprot id: A0A452G6V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9925:LOC108636640
gene id: 9925:LOC108636640
uniprot id: A0A452E2J0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9925:LDB3
gene id: 9925:LDB3
uniprot id: A0A452E1G1
uniprot id: A0A452E1H9
names: Subcellular Location Annotation
messages: Z line

9925:TET2
gene id: 9925:TET2
uniprot id: A0A452FBQ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9925:LOC102179687
gene id: 9925:LOC102179687
uniprot id: A0A452E0Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PITPNM2
gene id: 9925:PITPNM2
uniprot id: A0A452DZH8
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9925:UPK1B
gene id: 9925:UPK1B
uniprot id: A0A452G537
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

9925:PKIG
gene id: 9925:PKIG
uniprot id: A0A452FPZ5
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9925:RNF2
gene id: 9925:RNF2
uniprot id: A0A452E842
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

9925:SLC25A31
gene id: 9925:SLC25A31
uniprot id: A0A452F2M4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9925:SFRP2
gene id: 9925:SFRP2
uniprot id: A0A452FQT2
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ALDH7A1
gene id: 9925:ALDH7A1
uniprot id: A0A452DWP9
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

9925:IGF2R
gene id: 9925:IGF2R
uniprot id: A0A452E644
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CDX2
gene id: 9925:CDX2
uniprot id: A0A452G0A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9925:LOC102178921
gene id: 9925:LOC102178921
uniprot id: A0A452DZF2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:SERINC5
gene id: 9925:SERINC5
uniprot id: A0A452FYQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

9925:CTNNBL1
gene id: 9925:CTNNBL1
uniprot id: A0A452FPI8
names: Subcellular Location Annotation
messages: Nucleus

9925:TMEM138
gene id: 9925:TMEM138
uniprot id: A0A452F0C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9925:PLA2G12A
gene id: 9925:PLA2G12A
uniprot id: A0A8C2P4H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9925:TINAGL1
gene id: 9925:TINAGL1
uniprot id: A0A452FGH0
names: Similarity
messages: Belongs to the peptidase C1 family.

9925:ALG5
gene id: 9925:ALG5
uniprot id: A0A452ESM5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9925:NPLOC4
gene id: 9925:NPLOC4
uniprot id: A0A452DXL2
names: Similarity
messages: Belongs to the NPL4 family.

9925:SASS6
gene id: 9925:SASS6
uniprot id: A0A452F4Z2
names: Subcellular Location Annotation
messages: centrosome

9925:KCNS3
gene id: 9925:KCNS3
uniprot id: A0A452EEM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:MEIG1
gene id: 9925:MEIG1
uniprot id: A0A8C2R5J3
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9925:SCUBE1
gene id: 9925:SCUBE1
uniprot id: A0A452F2S7
uniprot id: A0A452F2V0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:GABARAPL1
gene id: 9925:GABARAPL1
uniprot id: A0A452G120
names: Similarity
messages: Belongs to the ATG8 family.

9925:NTSR2
gene id: 9925:NTSR2
uniprot id: A0A452EA07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:LHFPL5
gene id: 9925:LHFPL5
uniprot id: A0A452E743
names: Subcellular Location Annotation
messages: Membrane

9925:IRF2BP1
gene id: 9925:IRF2BP1
uniprot id: A0A452DNG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9925:NDUFAF2
gene id: 9925:NDUFAF2
uniprot id: A0A452GBD1
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9925:DKK3
gene id: 9925:DKK3
uniprot id: A0A452E7S5
names: Similarity
messages: Belongs to the dickkopf family.

9925:LOC102187315
gene id: 9925:LOC102187315
uniprot id: A0A452DPC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FN3K
gene id: 9925:FN3K
uniprot id: A0A452FE83
names: Similarity
messages: Belongs to the fructosamine kinase family.

9925:B4GAT1
gene id: 9925:B4GAT1
uniprot id: A0A452EHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:MEF2A
gene id: 9925:MEF2A
uniprot id: A0A452FYK6
uniprot id: A0A452FYU2
uniprot id: A0A452FZ97
uniprot id: U5HTH5
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC108636628
gene id: 9925:LOC108636628
uniprot id: A0A452E0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:MITF
gene id: 9925:MITF
uniprot id: A0A452FLK6
uniprot id: A0A452FM93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9925:PPP2CB
gene id: 9925:PPP2CB
uniprot id: A0A452DW17
names: Similarity
messages: Belongs to the PPP phosphatase family.

9925:KLHL21
gene id: 9925:KLHL21
uniprot id: A0A452G7L5
names: Subcellular Location Annotation
messages: spindle

9925:LIX1
gene id: 9925:LIX1
uniprot id: A0A452G9N8
names: Similarity
messages: Belongs to the LIX1 family.

9925:LOC102181565
gene id: 9925:LOC102181565
uniprot id: A0A452DVQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9925:WDR4
gene id: 9925:WDR4
uniprot id: A0A452FQC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit METTL1.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

9925:KCNK16
gene id: 9925:KCNK16
uniprot id: A0A452G460
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:TMEM170A
gene id: 9925:TMEM170A
uniprot id: A0A452G779
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9925:CORO1C
gene id: 9925:CORO1C
uniprot id: A0A452FNA0
names: Similarity
messages: Belongs to the WD repeat coronin family.

9925:LOC102189713
gene id: 9925:LOC102189713
uniprot id: A0A452EHR5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9925:NAB2
gene id: 9925:NAB2
uniprot id: A0A452F912
uniprot id: A0A8C2SF03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9925:PPP1R16B
gene id: 9925:PPP1R16B
uniprot id: A0A452ECE9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:TMEM198
gene id: 9925:TMEM198
uniprot id: A0A452FP33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9925:LOC108636626
gene id: 9925:LOC108636626
uniprot id: A0A452E3H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:ILVBL
gene id: 9925:ILVBL
uniprot id: A0A452F3Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

9925:FAM207A
gene id: 9925:FAM207A
uniprot id: A0A452F171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

9925:NEIL1
gene id: 9925:NEIL1
uniprot id: A0A452FPL4
names: Similarity
messages: Belongs to the FPG family.

9925:HDAC9
gene id: 9925:HDAC9
uniprot id: A0A452G4U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9925:GPRC5A
gene id: 9925:GPRC5A
uniprot id: A0A452E3V1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:ATP23
gene id: 9925:ATP23
uniprot id: A0A452G7Q4
names: Similarity
messages: Belongs to the peptidase M76 family.

9925:RDH10
gene id: 9925:RDH10
uniprot id: A0A452EW84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9925:TGM6
gene id: 9925:TGM6
uniprot id: A0A452FKJ6
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9925:DAO
gene id: 9925:DAO
uniprot id: A0A452EDQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9925:LOC102178842
gene id: 9925:LOC102178842
uniprot id: A0A452DVW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:IGFBP3
gene id: 9925:IGFBP3
uniprot id: K9MMZ7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:TNNT3
gene id: 9925:TNNT3
uniprot id: A0A089Q413
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9925:HOMER2
gene id: 9925:HOMER2
uniprot id: A0A452ELI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9925:PDHB
gene id: 9925:PDHB
uniprot id: A0A452EB05
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9925:LXN
gene id: 9925:LXN
uniprot id: A0A452G710
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9925:SLC7A6
gene id: 9925:SLC7A6
uniprot id: A0A452E345
names: Subcellular Location Annotation
messages: Membrane

9925:SNAP23
gene id: 9925:SNAP23
uniprot id: A0A452DUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9925:IRX6
gene id: 9925:IRX6
uniprot id: A0A452FH38
names: Subcellular Location Annotation
messages: Nucleus

9925:PSMA8
gene id: 9925:PSMA8
uniprot id: A0A452F784
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Nucleus

9925:LOC102173555
gene id: 9925:LOC102173555
uniprot id: A0A452EAZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC108633262
gene id: 9925:LOC108633262
uniprot id: A0A452FDX9
names: Similarity
messages: Belongs to the intermediate filament family.

9925:PTGR1
gene id: 9925:PTGR1
uniprot id: A0A452G830
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9925:TM9SF1
gene id: 9925:TM9SF1
uniprot id: A0A452FHN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9925:MEPCE
gene id: 9925:MEPCE
uniprot id: A0A452DXD9
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9925:EIF3K
gene id: 9925:EIF3K
uniprot id: A0A452FS00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9925:ZCCHC4
gene id: 9925:ZCCHC4
uniprot id: A0A452FPR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9925:MRRF
gene id: 9925:MRRF
uniprot id: A0A452G713
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9925:DHX29
gene id: 9925:DHX29
uniprot id: A0A452EHF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

9925:GDAP1L1
gene id: 9925:GDAP1L1
uniprot id: A0A452EWL2
names: Similarity
messages: Belongs to the GST superfamily.

9925:TBCD
gene id: 9925:TBCD
uniprot id: A0A452FBF4
uniprot id: A0A452FC13
names: Similarity
messages: Belongs to the TBCD family.

9925:SSBP1
gene id: 9925:SSBP1
uniprot id: A0A452EK39
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9925:RTFDC1
gene id: 9925:RTFDC1
uniprot id: A0A452EXA5
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9925:ETFB
gene id: 9925:ETFB
uniprot id: A0A452EW94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9925:LIN7B
gene id: 9925:LIN7B
uniprot id: A0A452F746
uniprot id: A0A8C2XWC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9925:PIK3R2
gene id: 9925:PIK3R2
uniprot id: A0A452DSB5
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9925:ACMSD
gene id: 9925:ACMSD
uniprot id: A0A452FBA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9925:CACFD1
gene id: 9925:CACFD1
uniprot id: A0A452FPT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

9925:APOA2
gene id: 9925:APOA2
uniprot id: A0A452FYY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein A2 family.
messages: Secreted

9925:LOC102185312
gene id: 9925:LOC102185312
uniprot id: A0A452ECU3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:EVA1C
gene id: 9925:EVA1C
uniprot id: A0A452EYH0
uniprot id: A0A452EYU6
names: Similarity
messages: Belongs to the EVA1 family.

9925:THEMIS
gene id: 9925:THEMIS
uniprot id: A0A452FBJ9
names: Similarity
messages: Belongs to the themis family.

9925:IHH
gene id: 9925:IHH
uniprot id: A0A452EW38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: Secreted
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9925:LOC102176897
gene id: 9925:LOC102176897
uniprot id: A0A452E7P2
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9925:CCNG2
gene id: 9925:CCNG2
uniprot id: A0A452DNI2
names: Similarity
messages: Belongs to the cyclin family.

9925:RMI1
gene id: 9925:RMI1
uniprot id: A0A452EEA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9925:CPNE2
gene id: 9925:CPNE2
uniprot id: A0A452EBM4
names: Similarity
messages: Belongs to the copine family.

9925:PDCL
gene id: 9925:PDCL
uniprot id: A0A452FTY2
names: Similarity
messages: Belongs to the phosducin family.

9925:MFSD11
gene id: 9925:MFSD11
uniprot id: A0A452G366
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9925:SLC35B3
gene id: 9925:SLC35B3
uniprot id: A0A452F3S4
uniprot id: A0A452F415
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9925:LOC102188961
gene id: 9925:LOC102188961
uniprot id: A0A452DZS1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GPCPD1
gene id: 9925:GPCPD1
uniprot id: A0A452F0B3
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9925:ANO6
gene id: 9925:ANO6
uniprot id: A0A452DMJ2
uniprot id: A0A452DMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

9925:LOC102185739
gene id: 9925:LOC102185739
uniprot id: A0A452FAQ3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:MPP6
gene id: 9925:MPP6
uniprot id: A0A452F828
uniprot id: A0A452F838
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9925:CUL5
gene id: 9925:CUL5
uniprot id: A0A452FUS4
names: Similarity
messages: Belongs to the cullin family.

9925:CNOT7
gene id: 9925:CNOT7
uniprot id: A0A452E9X8
uniprot id: A0A452E9Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9925:SRF
gene id: 9925:SRF
uniprot id: A0A452EB23
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC108636735
gene id: 9925:LOC108636735
uniprot id: A0A452DR12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KRTAP type 6 family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9925:PIH1D1
gene id: 9925:PIH1D1
uniprot id: A0A452G3V9
names: Similarity
messages: Belongs to the PIH1 family.

9925:COPS9
gene id: 9925:COPS9
uniprot id: A0A452DW83
names: Similarity
messages: Belongs to the CSN9 family.

9925:PDCD11
gene id: 9925:PDCD11
uniprot id: A0A452G1F2
names: Subcellular Location Annotation
messages: nucleolus

9925:LOC102175879
gene id: 9925:LOC102175879
uniprot id: A0A452DM69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NMS
gene id: 9925:NMS
uniprot id: A0A452E0Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9925:LOC102175997
gene id: 9925:LOC102175997
uniprot id: A0A452ECD8
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:RFX3
gene id: 9925:RFX3
uniprot id: A0A452E8U8
names: Subcellular Location Annotation
messages: Nucleus

9925:PAFAH1B1
gene id: 9925:PAFAH1B1
uniprot id: A0A452FXL9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: centrosome
messages: cytoskeleton
messages: spindle

9925:HNRNPA1
gene id: 9925:HNRNPA1
uniprot id: A0A452G1G3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:CTLA4
gene id: 9925:CTLA4
uniprot id: A0A8C2NF46
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9925:LOC102180549
gene id: 9925:LOC102180549
uniprot id: A0A452E5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9925:EDIL3
gene id: 9925:EDIL3
uniprot id: A0A452FCR9
uniprot id: A0A452FCU6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102172669
gene id: 9925:LOC102172669
uniprot id: A0A452DTW8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9925:CRELD1
gene id: 9925:CRELD1
uniprot id: A0A452EJ30
uniprot id: A0A8C2R508
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:NTS
gene id: 9925:NTS
uniprot id: A0A452ENW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9925:CSTF1
gene id: 9925:CSTF1
uniprot id: A0A452FZY9
uniprot id: A0A8C2P0H6
names: Subcellular Location Annotation
messages: Nucleus

9925:NDUFB9
gene id: 9925:NDUFB9
uniprot id: A0A452FEX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:CIAPIN1
gene id: 9925:CIAPIN1
uniprot id: A0A452FER7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9925:UBQLN1
gene id: 9925:UBQLN1
uniprot id: A0A452EQB9
uniprot id: A0A8C2NYJ6
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9925:HMX3
gene id: 9925:HMX3
uniprot id: A0A452E634
names: Subcellular Location Annotation
messages: Nucleus

9925:ATL3
gene id: 9925:ATL3
uniprot id: A0A452FNH4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9925:GRB14
gene id: 9925:GRB14
uniprot id: A0A452G5S5
uniprot id: A0A452G5T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9925:SUMF2
gene id: 9925:SUMF2
uniprot id: A0A452G7B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9925:LIPK
gene id: 9925:LIPK
uniprot id: A0A452F8S4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9925:TP53INP1
gene id: 9925:TP53INP1
uniprot id: A0A452DZ02
uniprot id: A0A8C2RYD0
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9925:LOC102188430
gene id: 9925:LOC102188430
uniprot id: A0A452E2H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102169211
gene id: 9925:LOC102169211
uniprot id: A0A452E6V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:CD8A
gene id: 9925:CD8A
uniprot id: A0A8C2NWB2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:YES1
gene id: 9925:YES1
uniprot id: A0A452DK39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:SUCLG2
gene id: 9925:SUCLG2
uniprot id: A0A452FAP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9925:LOC108636047
gene id: 9925:LOC108636047
uniprot id: A0A452DWU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:INTS7
gene id: 9925:INTS7
uniprot id: A0A452FI80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9925:MAN2C1
gene id: 9925:MAN2C1
uniprot id: A0A452EZP1
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

9925:RRM1
gene id: 9925:RRM1
uniprot id: A0A452F6S5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9925:LOC102188157
gene id: 9925:LOC102188157
uniprot id: A0A452DXE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:L3MBTL3
gene id: 9925:L3MBTL3
uniprot id: A0A452FR05
names: Subcellular Location Annotation
messages: Nucleus

9925:TAAR1
gene id: 9925:TAAR1
uniprot id: A0A8C2QWV9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:CENPH
gene id: 9925:CENPH
uniprot id: A0A452EJN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9925:BATF
gene id: 9925:BATF
uniprot id: A0A452DZD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9925:PRKCH
gene id: 9925:PRKCH
uniprot id: A0A452EXK6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9925:SLC6A6
gene id: 9925:SLC6A6
uniprot id: A0A452G034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

9925:FIP1L1
gene id: 9925:FIP1L1
uniprot id: A0A452G507
uniprot id: A0A452G559
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9925:CAMK1
gene id: 9925:CAMK1
uniprot id: A0A452F3K8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:SZRD1
gene id: 9925:SZRD1
uniprot id: A0A8C2NDX0
names: Similarity
messages: Belongs to the SZRD1 family.

9925:LOC102171511
gene id: 9925:LOC102171511
uniprot id: A0A452DV98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:KIAA0196
gene id: 9925:KIAA0196
uniprot id: A0A452EAS6
names: Similarity
messages: Belongs to the strumpellin family.

9925:CCDC58
gene id: 9925:CCDC58
uniprot id: A0A452E516
names: Similarity
messages: Belongs to the MIX23 family.

9925:LOC102175795
gene id: 9925:LOC102175795
uniprot id: A0A452FJ15
names: Similarity
messages: Belongs to the NDK family.

9925:TTLL9
gene id: 9925:TTLL9
uniprot id: A0A452EVK2
names: Similarity
messages: Belongs to the tubulin--tyrosine ligase family.

9925:ELP3
gene id: 9925:ELP3
uniprot id: A0A452G4D4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9925:GRB2
gene id: 9925:GRB2
uniprot id: A0A452ET74
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9925:ITFG1
gene id: 9925:ITFG1
uniprot id: A0A452FE79
names: Similarity
messages: Belongs to the TIP family.

9925:RPL10A
gene id: 9925:RPL10A
uniprot id: A0A452G5D5
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9925:IMMT
gene id: 9925:IMMT
uniprot id: A0A452G707
uniprot id: A0A452G789
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9925:AFF4
gene id: 9925:AFF4
uniprot id: A0A452EP86
uniprot id: A0A452EPX2
names: Similarity
messages: Belongs to the AF4 family.

9925:HSF4
gene id: 9925:HSF4
uniprot id: A0A452DQF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9925:PPP1R12C
gene id: 9925:PPP1R12C
uniprot id: A0A452F158
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9925:HCAR2
gene id: 9925:HCAR2
uniprot id: A0A452E503
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:SLC17A2
gene id: 9925:SLC17A2
uniprot id: A0A452DW75
names: Subcellular Location Annotation
messages: Membrane

9925:KRT35
gene id: 9925:KRT35
uniprot id: A0A452EQD3
names: Similarity
messages: Belongs to the intermediate filament family.

9925:CX3CR1
gene id: 9925:CX3CR1
uniprot id: A0A452DUY4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9925:NIT2
gene id: 9925:NIT2
uniprot id: A0A452G2F7
uniprot id: A0A8C2N856
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9925:PLAGL2
gene id: 9925:PLAGL2
uniprot id: A0A452G9X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9925:PDGFRB
gene id: 9925:PDGFRB
uniprot id: A0A452G073
uniprot id: A0A8C2NFV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.
messages: Lysosome lumen
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
messages: Vesicle

9925:NUDT18
gene id: 9925:NUDT18
uniprot id: A0A452G3E1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9925:FOPNL
gene id: 9925:FOPNL
uniprot id: A0A452FXK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9925:SVIL
gene id: 9925:SVIL
uniprot id: A0A452EVS5
names: Similarity
messages: Belongs to the villin/gelsolin family.

9925:TMED5
gene id: 9925:TMED5
uniprot id: A0A452EU71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with TMED9 and TMED10.
messages: Membrane
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.
messages: cis-Golgi network membrane

9925:LOC102179548
gene id: 9925:LOC102179548
uniprot id: A0A452DZZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PSMA5
gene id: 9925:PSMA5
uniprot id: A0A452DZK5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9925:KEF96 p01
gene id: 9925:KEF96_p01
uniprot id: Q8WF85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

9925:TM2D1
gene id: 9925:TM2D1
uniprot id: A0A452G7Q1
uniprot id: A0A8C2ND54
names: Subcellular Location Annotation
messages: Membrane

9925:LRRC8C
gene id: 9925:LRRC8C
uniprot id: A0A8C2R1E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9925:MSANTD3
gene id: 9925:MSANTD3
uniprot id: A0A452FVP9
names: Similarity
messages: Belongs to the MSANTD3 family.

9925:HPS6
gene id: 9925:HPS6
uniprot id: A0A452DNK4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9925:UBE3A
gene id: 9925:UBE3A
uniprot id: A0A452F0U5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9925:LOC102189594
gene id: 9925:LOC102189594
uniprot id: A0A452FZL0
uniprot id: A0A452FZP1
names: Subcellular Location Annotation
messages: Nucleus

9925:MAPK4
gene id: 9925:MAPK4
uniprot id: A0A452EGE5
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9925:TRAF5
gene id: 9925:TRAF5
uniprot id: A0A452EWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9925:CWC15
gene id: 9925:CWC15
uniprot id: A0A452EGS5
names: Similarity
messages: Belongs to the CWC15 family.

9925:TMEM151A
gene id: 9925:TMEM151A
uniprot id: A0A452FBN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9925:CCM2
gene id: 9925:CCM2
uniprot id: A0A452FDI4
names: Similarity
messages: Belongs to the CCM2 family.

9925:AP1M1
gene id: 9925:AP1M1
uniprot id: A0A3B8DGC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9925:LPXN
gene id: 9925:LPXN
uniprot id: A0A452FAM8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).
messages: focal adhesion
messages: perinuclear region
messages: podosome

9925:GUCY2D
gene id: 9925:GUCY2D
uniprot id: A0A452EPN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9925:OXSM
gene id: 9925:OXSM
uniprot id: A0A452FIJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9925:HMGCL
gene id: 9925:HMGCL
uniprot id: A0A452GAC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9925:RDH13
gene id: 9925:RDH13
uniprot id: A0A452F855
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:POLR3B
gene id: 9925:POLR3B
uniprot id: A0A452ESS0
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9925:STAT4
gene id: 9925:STAT4
uniprot id: A0A452FGT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9925:TOM1
gene id: 9925:TOM1
uniprot id: A0A452FWU3
uniprot id: A0A452FXK1
names: Similarity
messages: Belongs to the TOM1 family.

9925:SULT1B1
gene id: 9925:SULT1B1
uniprot id: A0A452DQX5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:LETM2
gene id: 9925:LETM2
uniprot id: A0A452EPM9
names: Subcellular Location Annotation
messages: Membrane

9925:NUDT2
gene id: 9925:NUDT2
uniprot id: A0A452ECY5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9925:ERN2
gene id: 9925:ERN2
uniprot id: A0A452FMT6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:BMP10
gene id: 9925:BMP10
uniprot id: A0A452G5K7
names: Similarity
messages: Belongs to the TGF-beta family.

9925:CPEB3
gene id: 9925:CPEB3
uniprot id: A0A452EZR3
names: Similarity
messages: Belongs to the RRM CPEB family.

9925:MPV17L2
gene id: 9925:MPV17L2
uniprot id: A0A452G4D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9925:SUSD4
gene id: 9925:SUSD4
uniprot id: A0A452EJ49
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CDO1
gene id: 9925:CDO1
uniprot id: A0A452FHB6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9925:DPH1
gene id: 9925:DPH1
uniprot id: A0A452DRF6
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.

9925:SEPT4
gene id: 9925:SEPT4
uniprot id: A0A452FZD4
uniprot id: A0A8C2PBJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9925:TSPAN2
gene id: 9925:TSPAN2
uniprot id: A0A452DUP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:REV3L
gene id: 9925:REV3L
uniprot id: A0A452FRQ8
uniprot id: A0A452FRW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9925:ALDH2
gene id: 9925:ALDH2
uniprot id: A0A452FSS5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:LOC108634214
gene id: 9925:LOC108634214
uniprot id: A0A452DMZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LCK
gene id: 9925:LCK
uniprot id: A0A452EIH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:FTH1
gene id: 9925:FTH1
uniprot id: A1E459
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9925:CDK8
gene id: 9925:CDK8
uniprot id: A0A452DSU4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102187559
gene id: 9925:LOC102187559
uniprot id: A0A452ESH2
names: Subcellular Location Annotation
messages: Secreted

9925:SHROOM1
gene id: 9925:SHROOM1
uniprot id: A0A452F566
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9925:NDUFB4
gene id: 9925:NDUFB4
uniprot id: A0A452EJU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:EYA4
gene id: 9925:EYA4
uniprot id: A0A452FL61
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus

9925:TIMM22
gene id: 9925:TIMM22
uniprot id: A0A452ET68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9925:ST3GAL2
gene id: 9925:ST3GAL2
uniprot id: A0A452FVE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:MYRF
gene id: 9925:MYRF
uniprot id: A0A452DPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

9925:SYN2
gene id: 9925:SYN2
uniprot id: A0A452G0M0
names: Similarity
messages: Belongs to the synapsin family.

9925:PDE1B
gene id: 9925:PDE1B
uniprot id: A0A452GAQ1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:CDH18
gene id: 9925:CDH18
uniprot id: A0A452FDZ8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:LOC102174001
gene id: 9925:LOC102174001
uniprot id: A0A452E915
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NAA38
gene id: 9925:NAA38
uniprot id: A0A452FUH6
uniprot id: A0A8C2RQU0
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

9925:ACTL8
gene id: 9925:ACTL8
uniprot id: A0A452FYV8
names: Similarity
messages: Belongs to the actin family.

9925:ERCC4
gene id: 9925:ERCC4
uniprot id: A0A452FPB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9925:RPL13
gene id: 9925:RPL13
uniprot id: A0A452DMW4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

9925:ADRA2B
gene id: 9925:ADRA2B
uniprot id: A0A452ES56
uniprot id: A0A8C2QXT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Membrane

9925:LRRC14
gene id: 9925:LRRC14
uniprot id: A0A452EAV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRAME family. LRRC14 subfamily.
messages: Cytoplasm

9925:LOC102175435
gene id: 9925:LOC102175435
uniprot id: A0A452DMJ1
names: Subcellular Location Annotation
messages: Membrane

9925:ADIPOR2
gene id: 9925:ADIPOR2
uniprot id: A0A452EQJ1
uniprot id: T1RTT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9925:LIX1L
gene id: 9925:LIX1L
uniprot id: A0A452EDD3
names: Similarity
messages: Belongs to the LIX1 family.

9925:TMEM136
gene id: 9925:TMEM136
uniprot id: A0A452FEK8
names: Subcellular Location Annotation
messages: Membrane

9925:USH1G
gene id: 9925:USH1G
uniprot id: A0A452E4X0
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9925:LOC102181105
gene id: 9925:LOC102181105
uniprot id: A0A452ESX1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9925:ENTPD4
gene id: 9925:ENTPD4
uniprot id: A0A452F168
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9925:IRF8
gene id: 9925:IRF8
uniprot id: A0A452GB37
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:ADAT2
gene id: 9925:ADAT2
uniprot id: A0A452DSW6
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9925:PPP1R2
gene id: 9925:PPP1R2
uniprot id: A0A452DU41
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9925:AHCY
gene id: 9925:AHCY
uniprot id: A0A452G990
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9925:SOD3
gene id: 9925:SOD3
uniprot id: B2CZE9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Nucleus

9925:LOC102179132
gene id: 9925:LOC102179132
uniprot id: A0A452G3W7
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MAP2K2
gene id: 9925:MAP2K2
uniprot id: A0A452ENE3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:GDPGP1
gene id: 9925:GDPGP1
uniprot id: A0A452DYJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9925:GLUL
gene id: 9925:GLUL
uniprot id: A0A452G2Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Membrane
messages: Microsome

9925:FAT4
gene id: 9925:FAT4
uniprot id: A0A452ESS9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PLBD2
gene id: 9925:PLBD2
uniprot id: A0A452G1X4
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9925:INA
gene id: 9925:INA
uniprot id: A0A452FIN8
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LOC102188498
gene id: 9925:LOC102188498
uniprot id: A0A452EDT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102185870
gene id: 9925:LOC102185870
uniprot id: A0A452ERK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:FAM63B
gene id: 9925:FAM63B
uniprot id: A0A452DWS9
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9925:ICAM4
gene id: 9925:ICAM4
uniprot id: A0A452DTI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9925:FOXH1
gene id: 9925:FOXH1
uniprot id: A0A452EQR0
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102184991
gene id: 9925:LOC102184991
uniprot id: A0A452DQD2
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9925:SH3RF1
gene id: 9925:SH3RF1
uniprot id: A0A452FSX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3RF family.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

9925:GMFG
gene id: 9925:GMFG
uniprot id: A0A452DMF9
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9925:SEPT8
gene id: 9925:SEPT8
uniprot id: A0A452EJB8
uniprot id: A0A452EK25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Presynapse
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: synaptic vesicle membrane

9925:SF3A3
gene id: 9925:SF3A3
uniprot id: A0A452FFE9
names: Similarity
messages: Belongs to the SF3A3 family.

9925:ATP5L
gene id: 9925:ATP5L
uniprot id: A0A452DYD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9925:LOC102179277
gene id: 9925:LOC102179277
uniprot id: A0A452EEU2
names: Similarity
messages: Belongs to the cornifelin family.

9925:MS4A13
gene id: 9925:MS4A13
uniprot id: A0A452FH21
names: Similarity
messages: Belongs to the MS4A family.

9925:PCBD1
gene id: 9925:PCBD1
uniprot id: A0A452FGX6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9925:ARSI
gene id: 9925:ARSI
uniprot id: A0A452DTH8
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9925:AP2B1
gene id: 9925:AP2B1
uniprot id: A0A452F9D0
uniprot id: A0A452F9H7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9925:CRISP3
gene id: 9925:CRISP3
uniprot id: D6PX62
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:RARS
gene id: 9925:RARS
uniprot id: A0A452FHC1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:CTDP1
gene id: 9925:CTDP1
uniprot id: A0A452EVD5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

9925:LOC102188627
gene id: 9925:LOC102188627
uniprot id: A0A452F2G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9925:CDK20
gene id: 9925:CDK20
uniprot id: A0A452EEB7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:RIDA
gene id: 9925:RIDA
uniprot id: P80601
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Cytoplasm
messages: Expressed by various malignant neoplasms.
messages: Homotrimer (PubMed:12925811). Interacts with YTHDF2 (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: Peroxisome

9925:HMOX1
gene id: 9925:HMOX1
uniprot id: F6M7A9
names: Similarity
messages: Belongs to the heme oxygenase family.

9925:SLC25A44
gene id: 9925:SLC25A44
uniprot id: A0A452E8C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:SCNN1B
gene id: 9925:SCNN1B
uniprot id: A0A452FJC0
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102172503
gene id: 9925:LOC102172503
uniprot id: A0A452EGJ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9925:GNG5
gene id: 9925:GNG5
uniprot id: A0A452ETY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:NOS1
gene id: 9925:NOS1
uniprot id: A0A452G3C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOS family.
messages: dendritic spine
messages: sarcolemma

9925:NQO1
gene id: 9925:NQO1
uniprot id: A0A452G4A1
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9925:LCOR
gene id: 9925:LCOR
uniprot id: A0A452DYB7
names: Subcellular Location Annotation
messages: Nucleus

9925:VASP
gene id: 9925:VASP
uniprot id: A0A452EB37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9925:KCNB1
gene id: 9925:KCNB1
uniprot id: A0A452G4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: sarcolemma
messages: synaptosome

9925:LOC102188153
gene id: 9925:LOC102188153
uniprot id: A0A452E1T5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9925:RBFOX2
gene id: 9925:RBFOX2
uniprot id: A0A452EJF3
uniprot id: A0A8C2N548
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9925:MFF
gene id: 9925:MFF
uniprot id: A0A452DQE4
uniprot id: A0A452DQJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
messages: synaptic vesicle

9925:SCIN
gene id: 9925:SCIN
uniprot id: A0A452EL54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

9925:LOC106502637
gene id: 9925:LOC106502637
uniprot id: A0A452E806
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102182036
gene id: 9925:LOC102182036
uniprot id: A0A8C2PAR7
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9925:HABP2
gene id: 9925:HABP2
uniprot id: A0A452FA32
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:LOC102176364
gene id: 9925:LOC102176364
uniprot id: A0A452FBV6
names: Similarity
messages: Belongs to the SERF family.

9925:NOB1
gene id: 9925:NOB1
uniprot id: A0A452GAI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9925:FAM163A
gene id: 9925:FAM163A
uniprot id: A0A452G5S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9925:LOC102185323
gene id: 9925:LOC102185323
uniprot id: A0A452E1V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:SLX1A
gene id: 9925:SLX1A
uniprot id: A0A452FGC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
messages: Forms a heterodimer with SLX4.
messages: Nucleus

9925:NPC1L1
gene id: 9925:NPC1L1
uniprot id: A0A452EN38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9925:SMUG1
gene id: 9925:SMUG1
uniprot id: A0A452E1S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9925:FAM69C
gene id: 9925:FAM69C
uniprot id: A0A452DL99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

9925:SLC25A4
gene id: 9925:SLC25A4
uniprot id: A0A452G8Y9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9925:THRAP3
gene id: 9925:THRAP3
uniprot id: A0A452FQG3
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9925:CREBBP
gene id: 9925:CREBBP
uniprot id: A0A452F179
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LOC102169480
gene id: 9925:LOC102169480
uniprot id: A0A452G3J5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:SUPT3H
gene id: 9925:SUPT3H
uniprot id: A0A452EWB3
names: Subcellular Location Annotation
messages: Nucleus

9925:ATP2A2
gene id: 9925:ATP2A2
uniprot id: A0A452G1T7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9925:ITGB8
gene id: 9925:ITGB8
uniprot id: A0A452F9L9
uniprot id: A0A452F9X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9925:RPL38
gene id: 9925:RPL38
uniprot id: A0A8C2SBG0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9925:ALDH3A1
gene id: 9925:ALDH3A1
uniprot id: A0A452G1D4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:PLLP
gene id: 9925:PLLP
uniprot id: A0A452DVY2
names: Subcellular Location Annotation
messages: Membrane

9925:PPM1D
gene id: 9925:PPM1D
uniprot id: A0A452FV70
names: Similarity
messages: Belongs to the PP2C family.

9925:SMARCAL1
gene id: 9925:SMARCAL1
uniprot id: A0A452G2E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9925:ABHD2
gene id: 9925:ABHD2
uniprot id: A0A452FNQ5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9925:CDK2
gene id: 9925:CDK2
uniprot id: A0A452DTW9
uniprot id: A0MSV8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:KEF96 p08
gene id: 9925:KEF96_p08
uniprot id: D2KMK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9925:RAB3A
gene id: 9925:RAB3A
uniprot id: A0A452DUL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9925:SOD1
gene id: 9925:SOD1
uniprot id: Q5FB29
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.
messages: Nucleus
messages: Palmitoylation helps nuclear targeting and decreases catalytic activity.
messages: Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.

9925:GSS
gene id: 9925:GSS
uniprot id: A0A452G5S8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9925:LOC108633916
gene id: 9925:LOC108633916
uniprot id: A0A452E3P2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:ORMDL2
gene id: 9925:ORMDL2
uniprot id: A0A452F5J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9925:GAREM1
gene id: 9925:GAREM1
uniprot id: A0A452DL39
names: Similarity
messages: Belongs to the GAREM family.

9925:MSRB3
gene id: 9925:MSRB3
uniprot id: A0A452ECI2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9925:TRPC6
gene id: 9925:TRPC6
uniprot id: A0A452EEH4
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102179033
gene id: 9925:LOC102179033
uniprot id: A0A452DW41
names: Similarity
messages: Belongs to the PRAME family.

9925:FOLH1B
gene id: 9925:FOLH1B
uniprot id: A0A452EHA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9925:TMEM70
gene id: 9925:TMEM70
uniprot id: A0A452FBN8
names: Similarity
messages: Belongs to the TMEM70 family.

9925:LOC102177863
gene id: 9925:LOC102177863
uniprot id: A0A452DQX1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:WAPL
gene id: 9925:WAPL
uniprot id: A0A452EI00
names: Similarity
messages: Belongs to the WAPL family.

9925:RABGGTB
gene id: 9925:RABGGTB
uniprot id: A0A452EFU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9925:ADPRHL2
gene id: 9925:ADPRHL2
uniprot id: A0A452E8X2
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9925:RHO
gene id: 9925:RHO
uniprot id: A0A452F800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9925:LOC102186455
gene id: 9925:LOC102186455
uniprot id: A0A452E852
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:LOC102171808
gene id: 9925:LOC102171808
uniprot id: A0A452E3R9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:SEPT9
gene id: 9925:SEPT9
uniprot id: A0A452G9N2
uniprot id: A0A452GA63
uniprot id: A0A452GA68
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9925:TMTC4
gene id: 9925:TMTC4
uniprot id: A0A452ENZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9925:LOC102182458
gene id: 9925:LOC102182458
uniprot id: A0A452DY82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC102168248
gene id: 9925:LOC102168248
uniprot id: A0A452EDT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TTC38
gene id: 9925:TTC38
uniprot id: A0A452EVV8
names: Similarity
messages: Belongs to the TTC38 family.

9925:HHAT
gene id: 9925:HHAT
uniprot id: A0A452E3S0
names: Subcellular Location Annotation
messages: Membrane

9925:LOC106501755
gene id: 9925:LOC106501755
uniprot id: A0A452DM79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9925:LOC102190919
gene id: 9925:LOC102190919
uniprot id: A0A452FDW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

9925:LCMT1
gene id: 9925:LCMT1
uniprot id: A0A452EQV1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9925:PIK3CD
gene id: 9925:PIK3CD
uniprot id: A0A452FD91
uniprot id: A0A8C2RE34
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9925:NAPB
gene id: 9925:NAPB
uniprot id: A0A452FD59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9925:ALOX5
gene id: 9925:ALOX5
uniprot id: A0A452FR96
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SRD5A2
gene id: 9925:SRD5A2
uniprot id: A0A452G3Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9925:PIGB
gene id: 9925:PIGB
uniprot id: A0A452F7F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9925:LOC102174188
gene id: 9925:LOC102174188
uniprot id: A0A452DXR8
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

9925:GPR15
gene id: 9925:GPR15
uniprot id: A0A8C2NCY4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:NCLN
gene id: 9925:NCLN
uniprot id: A0A452FL43
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

9925:LNPK
gene id: 9925:LNPK
uniprot id: A0A452EC74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9925:SLC5A2
gene id: 9925:SLC5A2
uniprot id: A0A452EK48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9925:UPP2
gene id: 9925:UPP2
uniprot id: A0A452F2A2
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9925:SCAP
gene id: 9925:SCAP
uniprot id: A0A452DVU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9925:KAT2A
gene id: 9925:KAT2A
uniprot id: A0A452FHR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9925:MIGA2
gene id: 9925:MIGA2
uniprot id: A0A452FIV9
names: Similarity
messages: Belongs to the mitoguardin family.

9925:KEF96 p02
gene id: 9925:KEF96_p02
uniprot id: E0XJX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion membrane

9925:PELI2
gene id: 9925:PELI2
uniprot id: A0A8C2P0P4
names: Similarity
messages: Belongs to the pellino family.

9925:GMNN
gene id: 9925:GMNN
uniprot id: A0A452FAV7
uniprot id: A0A8C2RHY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9925:SHC1
gene id: 9925:SHC1
uniprot id: A0A452EE60
uniprot id: A0A8C2RXG1
names: Subcellular Location Annotation
messages: Cytoplasm

9925:PGM2
gene id: 9925:PGM2
uniprot id: A0A452ERF7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9925:CALB2
gene id: 9925:CALB2
uniprot id: A0A452F8K1
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9925:SORBS2
gene id: 9925:SORBS2
uniprot id: A0A452F3Y9
names: Subcellular Location Annotation
messages: focal adhesion

9925:LOC102168699
gene id: 9925:LOC102168699
uniprot id: A0A452FPK7
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9925:LOC102181348
gene id: 9925:LOC102181348
uniprot id: A0A452E7H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9925:GPR35
gene id: 9925:GPR35
uniprot id: A0A452DQS4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:PAQR3
gene id: 9925:PAQR3
uniprot id: A0A452EFD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9925:ST7
gene id: 9925:ST7
uniprot id: A0A452FCI7
uniprot id: A0A452FCU4
uniprot id: A0A452FCV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9925:MRPL54
gene id: 9925:MRPL54
uniprot id: A0A452G822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9925:FGF7
gene id: 9925:FGF7
uniprot id: A0A452ER05
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:ACVR1
gene id: 9925:ACVR1
uniprot id: A0A452FPI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:CRYZ
gene id: 9925:CRYZ
uniprot id: A0A452EZS5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9925:LOC102170668
gene id: 9925:LOC102170668
uniprot id: A0A452DU43
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

9925:ATP6V1F
gene id: 9925:ATP6V1F
uniprot id: A0A452DWZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9925:LYVE1
gene id: 9925:LYVE1
uniprot id: A0A452G259
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:NKX1-2
gene id: 9925:NKX1-2
uniprot id: A0A452DZG2
names: Subcellular Location Annotation
messages: Nucleus

9925:MTMR2
gene id: 9925:MTMR2
uniprot id: A0A452EXY6
uniprot id: A0A452EY77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9925:CDH7
gene id: 9925:CDH7
uniprot id: A0A452EV60
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:SIAH1
gene id: 9925:SIAH1
uniprot id: A0A452F2I8
uniprot id: A0A8C2XZT0
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9925:ADCYAP1R1
gene id: 9925:ADCYAP1R1
uniprot id: A0A452DSU8
uniprot id: A0A452DSX2
names: Subcellular Location Annotation
messages: Membrane

9925:GTF2E2
gene id: 9925:GTF2E2
uniprot id: A0A452FI96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9925:ITGAM
gene id: 9925:ITGAM
uniprot id: A0A452EK18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:LOC102182191
gene id: 9925:LOC102182191
uniprot id: A0A452DM30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RNASE12
gene id: 9925:RNASE12
uniprot id: A0A8C2RQF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9925:RPS6KB2
gene id: 9925:RPS6KB2
uniprot id: A0A452E085
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Cytoplasm

9925:LOC102177619
gene id: 9925:LOC102177619
uniprot id: A0A452DN28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:C28H10orf53
gene id: 9925:C28H10orf53
uniprot id: A0A452DT39
names: Similarity
messages: Belongs to the UPF0728 family.

9925:PCYT2
gene id: 9925:PCYT2
uniprot id: A0A452DU86
names: Similarity
messages: Belongs to the cytidylyltransferase family.

9925:LOC102184552
gene id: 9925:LOC102184552
uniprot id: A0A452E365
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:AMPD3
gene id: 9925:AMPD3
uniprot id: A0A452EG84
uniprot id: A0A452EG85
uniprot id: A0A452EGC0
uniprot id: A0A452EGJ2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9925:SLC23A2
gene id: 9925:SLC23A2
uniprot id: A0A452ENZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9925:CLCN1
gene id: 9925:CLCN1
uniprot id: A0A452FI86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9925:RALA
gene id: 9925:RALA
uniprot id: A0A452EHC3
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9925:CLP1
gene id: 9925:CLP1
uniprot id: A0A452FTT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9925:SNPH
gene id: 9925:SNPH
uniprot id: A0A8C2P8G0
names: Subcellular Location Annotation
messages: Membrane

9925:TET1
gene id: 9925:TET1
uniprot id: A0A452E1V0
uniprot id: A0A452E1W7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9925:FAM160A2
gene id: 9925:FAM160A2
uniprot id: A0A452FHR0
names: Similarity
messages: Belongs to the FHIP family.

9925:SF3B5
gene id: 9925:SF3B5
uniprot id: A0A452DVC0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9925:LOC102182187
gene id: 9925:LOC102182187
uniprot id: A0A452FZX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9925:STAT1
gene id: 9925:STAT1
uniprot id: A0A452E166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9925:TEKT3
gene id: 9925:TEKT3
uniprot id: A0A452EFQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9925:LOC102175794
gene id: 9925:LOC102175794
uniprot id: A0A452EH04
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9925:LOC102177850
gene id: 9925:LOC102177850
uniprot id: J9QEX1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9925:CHST9
gene id: 9925:CHST9
uniprot id: A0A452FKC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:MEAF6
gene id: 9925:MEAF6
uniprot id: A0A452DP08
uniprot id: A0A452DP38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

9925:TMEM43
gene id: 9925:TMEM43
uniprot id: A0A452FFF7
uniprot id: A0A452FG13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

9925:NDUFV2
gene id: 9925:NDUFV2
uniprot id: A0A452ERM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9925:LTBR
gene id: 9925:LTBR
uniprot id: I6SMD9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TMEM30B
gene id: 9925:TMEM30B
uniprot id: A0A452DZN3
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9925:MRPL23
gene id: 9925:MRPL23
uniprot id: A0A452F8P5
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9925:MVP
gene id: 9925:MVP
uniprot id: A0A452DVK6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9925:NAA35
gene id: 9925:NAA35
uniprot id: A0A452EJC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9925:UNC5CL
gene id: 9925:UNC5CL
uniprot id: A0A452E3X5
names: Similarity
messages: Belongs to the unc-5 family.

9925:CCNB2
gene id: 9925:CCNB2
uniprot id: A0A452EMV1
names: Similarity
messages: Belongs to the cyclin family.

9925:LOC102181272
gene id: 9925:LOC102181272
uniprot id: A0A452DR11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NAA30
gene id: 9925:NAA30
uniprot id: A0A452ENW7
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

9925:RGS2
gene id: 9925:RGS2
uniprot id: A0A452F0N8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

9925:LOC102182821
gene id: 9925:LOC102182821
uniprot id: A0A452F5V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9925:GHSR
gene id: 9925:GHSR
uniprot id: A0A452E0S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

9925:RPS13
gene id: 9925:RPS13
uniprot id: A0A452FSE1
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9925:CMTM6
gene id: 9925:CMTM6
uniprot id: A0A452E5C6
names: Subcellular Location Annotation
messages: Membrane

9925:FAM69A
gene id: 9925:FAM69A
uniprot id: A0A452FDA5
uniprot id: A0A452FDJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

9925:C11H2orf68
gene id: 9925:C11H2orf68
uniprot id: A0A452G8C8
names: Similarity
messages: Belongs to the UPF0561 family.

9925:EPC1
gene id: 9925:EPC1
uniprot id: A0A452DRY9
uniprot id: A0A452DS09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9925:MIS12
gene id: 9925:MIS12
uniprot id: A0A452DX06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9925:KIF3C
gene id: 9925:KIF3C
uniprot id: A0A452DR32
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:LOC102174762
gene id: 9925:LOC102174762
uniprot id: A0A452EUD9
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9925:ITPRIPL2
gene id: 9925:ITPRIPL2
uniprot id: A0A452E2Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9925:RNASEH2A
gene id: 9925:RNASEH2A
uniprot id: A0A452ELC4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9925:DPH5
gene id: 9925:DPH5
uniprot id: A0A452FQY7
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9925:LTA
gene id: 9925:LTA
uniprot id: A0A452EMR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9925:AKAP5
gene id: 9925:AKAP5
uniprot id: A0A452E7F0
names: Subcellular Location Annotation
messages: Membrane

9925:BCAR1
gene id: 9925:BCAR1
uniprot id: A0A452G738
uniprot id: A0A452G743
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9925:LOC102172204
gene id: 9925:LOC102172204
uniprot id: A0A452G962
names: Similarity
messages: Belongs to the multicopper oxidase family.

9925:AIMP2
gene id: 9925:AIMP2
uniprot id: A0A452ENH7
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9925:MCU
gene id: 9925:MCU
uniprot id: A0A452F8G5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9925:ARSK
gene id: 9925:ARSK
uniprot id: A0A452ETX3
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9925:C2
gene id: 9925:C2
uniprot id: A0A452ELE7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:FAM160B1
gene id: 9925:FAM160B1
uniprot id: A0A452FF64
names: Similarity
messages: Belongs to the FHIP family.

9925:TIGD3
gene id: 9925:TIGD3
uniprot id: A0A452DS52
names: Subcellular Location Annotation
messages: Nucleus

9925:DARS2
gene id: 9925:DARS2
uniprot id: A0A452FZG6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9925:LOC102174170
gene id: 9925:LOC102174170
uniprot id: A0A097KUQ8
uniprot id: A0A452G686
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9925:LOC102169822
gene id: 9925:LOC102169822
uniprot id: A0A8C2SCW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9925:DLGAP1
gene id: 9925:DLGAP1
uniprot id: A0A452F312
names: Similarity
messages: Belongs to the SAPAP family.

9925:CNEP1R1
gene id: 9925:CNEP1R1
uniprot id: A0A452FKZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9925:UGGT2
gene id: 9925:UGGT2
uniprot id: A0A452DT37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9925:STOML1
gene id: 9925:STOML1
uniprot id: A0A452FF35
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9925:FAM83A
gene id: 9925:FAM83A
uniprot id: A0A452E699
names: Similarity
messages: Belongs to the FAM83 family.

9925:PLCD4
gene id: 9925:PLCD4
uniprot id: A0A8C2NYI5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
messages: Nucleus

9925:PDE1A
gene id: 9925:PDE1A
uniprot id: A0A452FWF0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:TMEM132A
gene id: 9925:TMEM132A
uniprot id: A0A452FCT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9925:FREM1
gene id: 9925:FREM1
uniprot id: A0A452G5J2
names: Similarity
messages: Belongs to the FRAS1 family.

9925:LOC102170832
gene id: 9925:LOC102170832
uniprot id: A0A452DYU4
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9925:RPP14
gene id: 9925:RPP14
uniprot id: A0A452F9G4
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9925:CAPN5
gene id: 9925:CAPN5
uniprot id: A0A452E1M5
names: Similarity
messages: Belongs to the peptidase C2 family.

9925:PSPH
gene id: 9925:PSPH
uniprot id: A0A452DYB1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

9925:RAD17
gene id: 9925:RAD17
uniprot id: A0A452FFX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9925:LOC102184705
gene id: 9925:LOC102184705
uniprot id: A0A452DY73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CAB39L
gene id: 9925:CAB39L
uniprot id: A0A452FEY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9925:PLAG1
gene id: 9925:PLAG1
uniprot id: A0A452DLZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9925:PSEN2
gene id: 9925:PSEN2
uniprot id: A0A452G168
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

9925:CFL2
gene id: 9925:CFL2
uniprot id: A0A452ERY2
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9925:DNAJC2
gene id: 9925:DNAJC2
uniprot id: A0A452FIC9
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: cytosol

9925:MAP4
gene id: 9925:MAP4
uniprot id: A0A452EIY1
uniprot id: A0A452EJA1
names: Subcellular Location Annotation
messages: cytoskeleton

9925:SLC5A10
gene id: 9925:SLC5A10
uniprot id: A0A452ERP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9925:LY6D
gene id: 9925:LY6D
uniprot id: A0A8C2XY91
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:FAM189A1
gene id: 9925:FAM189A1
uniprot id: A0A452FPR7
names: Similarity
messages: Belongs to the ENTREP family.

9925:BANF2
gene id: 9925:BANF2
uniprot id: A0A452DXY5
names: Subcellular Location Annotation
messages: Nucleus

9925:TMEM184B
gene id: 9925:TMEM184B
uniprot id: A0A452FSF9
uniprot id: A0A452FSG4
names: Subcellular Location Annotation
messages: Membrane

9925:EIF6
gene id: 9925:EIF6
uniprot id: A0A452E7Q2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9925:YARS2
gene id: 9925:YARS2
uniprot id: A0A452DNJ8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:SENP6
gene id: 9925:SENP6
uniprot id: A0A452DZQ4
names: Similarity
messages: Belongs to the peptidase C48 family.

9925:PARK7
gene id: 9925:PARK7
uniprot id: A0A452FM54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9925:FAM168B
gene id: 9925:FAM168B
uniprot id: A0A452FVI3
names: Similarity
messages: Belongs to the FAM168 family.

9925:CLDN10
gene id: 9925:CLDN10
uniprot id: A0A452ENS3
uniprot id: A0A452EPB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:SIDT1
gene id: 9925:SIDT1
uniprot id: A0A452EW95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9925:CACNB3
gene id: 9925:CACNB3
uniprot id: A0A452ECF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9925:NTMT1
gene id: 9925:NTMT1
uniprot id: A0A452DYM0
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9925:BICD2
gene id: 9925:BICD2
uniprot id: A0A452FM02
names: Similarity
messages: Belongs to the BicD family.

9925:FYN
gene id: 9925:FYN
uniprot id: A0A452DZ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:APOA1
gene id: 9925:APOA1
uniprot id: A0A452FI14
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9925:LOC102178311
gene id: 9925:LOC102178311
uniprot id: A0A452E9A7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9925:RAD1
gene id: 9925:RAD1
uniprot id: A0A452EPD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9925:PDGFA
gene id: 9925:PDGFA
uniprot id: A0A452EPV8
uniprot id: A0A452EQS6
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9925:ME2
gene id: 9925:ME2
uniprot id: A0A452DMC0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9925:LOC102187674
gene id: 9925:LOC102187674
uniprot id: A0A452E8H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CUL3
gene id: 9925:CUL3
uniprot id: A0A452DVZ8
names: Similarity
messages: Belongs to the cullin family.

9925:SRSF1
gene id: 9925:SRSF1
uniprot id: A0A452E5C9
names: Similarity
messages: Belongs to the splicing factor SR family.

9925:TMEM163
gene id: 9925:TMEM163
uniprot id: A0A452G2E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: May bind zinc and other divalent cations and recruit them to vesicular organelles.
messages: Membrane
messages: synaptic vesicle membrane

9925:LOC102190534
gene id: 9925:LOC102190534
uniprot id: A0A452DS58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:KCNC1
gene id: 9925:KCNC1
uniprot id: A0A452E4M2
names: Subcellular Location Annotation
messages: Membrane

9925:BRINP2
gene id: 9925:BRINP2
uniprot id: A0A452ELS2
names: Similarity
messages: Belongs to the BRINP family.

9925:CENPV
gene id: 9925:CENPV
uniprot id: A0A452FZV7
names: Similarity
messages: Belongs to the Gfa family.

9925:TTC27
gene id: 9925:TTC27
uniprot id: A0A452F011
names: Similarity
messages: Belongs to the TTC27 family.

9925:PCNX1
gene id: 9925:PCNX1
uniprot id: A0A452G791
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9925:PRR15L
gene id: 9925:PRR15L
uniprot id: A0A452DWH1
names: Similarity
messages: Belongs to the PRR15 family.

9925:HDAC2
gene id: 9925:HDAC2
uniprot id: A0A452FXL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9925:ELAC2
gene id: 9925:ELAC2
uniprot id: A0A452G5W7
names: Similarity
messages: Belongs to the RNase Z family.

9925:TVP23A
gene id: 9925:TVP23A
uniprot id: A0A452E0Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9925:ESR2
gene id: 9925:ESR2
uniprot id: B5AFX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9925:RSG1
gene id: 9925:RSG1
uniprot id: A0A452DRN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9925:CLDN11
gene id: 9925:CLDN11
uniprot id: A0A452E6K8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:HMOX2
gene id: 9925:HMOX2
uniprot id: A0A452G6X5
names: Similarity
messages: Belongs to the heme oxygenase family.

9925:LOC102178740
gene id: 9925:LOC102178740
uniprot id: A0A452EL39
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:TPX2
gene id: 9925:TPX2
uniprot id: A0A452FVK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

9925:TEAD1
gene id: 9925:TEAD1
uniprot id: A0A452EPT3
uniprot id: A0A452EQ39
uniprot id: A0A452EQY1
uniprot id: A0A452EQZ0
uniprot id: A0A452ER08
names: Subcellular Location Annotation
messages: Nucleus

9925:XIRP1
gene id: 9925:XIRP1
uniprot id: A0A452EB48
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9925:ASPA
gene id: 9925:ASPA
uniprot id: A0A452G2W5
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9925:LOC102188213
gene id: 9925:LOC102188213
uniprot id: A0A452DN01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:OPRD1
gene id: 9925:OPRD1
uniprot id: A0A452EVR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:C11H9orf78
gene id: 9925:C11H9orf78
uniprot id: A0A452GA07
names: Similarity
messages: Belongs to the TLS1 family.

9925:EGFL7
gene id: 9925:EGFL7
uniprot id: A0A8C2SB73
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102182904
gene id: 9925:LOC102182904
uniprot id: A0A452DP77
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SEPT2
gene id: 9925:SEPT2
uniprot id: A0A452G8J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9925:LOC102190016
gene id: 9925:LOC102190016
uniprot id: A0A452E5X4
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9925:HFE
gene id: 9925:HFE
uniprot id: A0A452E3Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MHC class I family.
messages: Binds TFR through the extracellular domain in a pH-dependent manner.
messages: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
messages: Cell membrane

9925:JMJD1C
gene id: 9925:JMJD1C
uniprot id: A0A452FMA1
names: Subcellular Location Annotation
messages: Nucleus

9925:NOC3L
gene id: 9925:NOC3L
uniprot id: A0A452FVW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

9925:COCH
gene id: 9925:COCH
uniprot id: A0A8C2PMD6
names: Function
messages: Plays a role in the control of cell shape and motility in the trabecular meshwork.

9925:HCAR1
gene id: 9925:HCAR1
uniprot id: A0A452E6W7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:AMBP
gene id: 9925:AMBP
uniprot id: A0A8C2QU99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9925:MGRN1
gene id: 9925:MGRN1
uniprot id: A0A452DYQ1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9925:SULT4A1
gene id: 9925:SULT4A1
uniprot id: A0A452F9S3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:ATP6V0C
gene id: 9925:ATP6V0C
uniprot id: A0A452FRS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9925:TEKT1
gene id: 9925:TEKT1
uniprot id: A0A452FF21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9925:RNASEH1
gene id: 9925:RNASEH1
uniprot id: A0A452FM14
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9925:NR2F6
gene id: 9925:NR2F6
uniprot id: A0A452G636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:LOC102173838
gene id: 9925:LOC102173838
uniprot id: A0A452DP13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MIF
gene id: 9925:MIF
uniprot id: A0A452FQK5
names: Similarity
messages: Belongs to the MIF family.

9925:LYPLAL1
gene id: 9925:LYPLAL1
uniprot id: A0A452E3L4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9925:CSNK2A1
gene id: 9925:CSNK2A1
uniprot id: A0A452FP18
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:ACSM4
gene id: 9925:ACSM4
uniprot id: A0A452F6C5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:PLAA
gene id: 9925:PLAA
uniprot id: A0A452ENB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9925:SNX4
gene id: 9925:SNX4
uniprot id: A0A452EGT9
names: Similarity
messages: Belongs to the sorting nexin family.

9925:CD70
gene id: 9925:CD70
uniprot id: A0A452G8J0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9925:ABCC3
gene id: 9925:ABCC3
uniprot id: A0A452EPE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9925:SLC7A8
gene id: 9925:SLC7A8
uniprot id: A0A452DTW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9925:SH3YL1
gene id: 9925:SH3YL1
uniprot id: A0A452FRI5
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9925:SVOP
gene id: 9925:SVOP
uniprot id: A0A452FSU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9925:CRX
gene id: 9925:CRX
uniprot id: A0A452FR42
names: Subcellular Location Annotation
messages: Nucleus

9925:PDK2
gene id: 9925:PDK2
uniprot id: A0A452FM72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9925:CCT6B
gene id: 9925:CCT6B
uniprot id: A0A452FUL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9925:LOC108634081
gene id: 9925:LOC108634081
uniprot id: A0A452FMT2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.

9925:OAT
gene id: 9925:OAT
uniprot id: A0A452EKJ3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9925:STX5
gene id: 9925:STX5
uniprot id: A0A452G6N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9925:MYO5A
gene id: 9925:MYO5A
uniprot id: A0A452FET7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:SLIT1
gene id: 9925:SLIT1
uniprot id: A0A452E6V5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:TCTE3
gene id: 9925:TCTE3
uniprot id: A0A452DQJ7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9925:RARRES1
gene id: 9925:RARRES1
uniprot id: A0A452FFK6
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9925:NDUFA8
gene id: 9925:NDUFA8
uniprot id: A0A452FT17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9925:RPS16
gene id: 9925:RPS16
uniprot id: A0A452FWU9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9925:GUCA2B
gene id: 9925:GUCA2B
uniprot id: A0A452FAQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9925:EMC6
gene id: 9925:EMC6
uniprot id: A0A452DWA1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LOC102184840
gene id: 9925:LOC102184840
uniprot id: A0A452E2J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EGR1
gene id: 9925:EGR1
uniprot id: A0A452FQ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9925:PHF10
gene id: 9925:PHF10
uniprot id: A0A452FG82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

9925:EIF4E
gene id: 9925:EIF4E
uniprot id: A0A452E0G5
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9925:RRM2
gene id: 9925:RRM2
uniprot id: A0A452E129
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9925:PPP1CB
gene id: 9925:PPP1CB
uniprot id: A0A452EJ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9925:GNRH1
gene id: 9925:GNRH1
uniprot id: A0A452EVB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

9925:TTC39C
gene id: 9925:TTC39C
uniprot id: A0A452DZH3
names: Similarity
messages: Belongs to the TTC39 family.

9925:MAT1A
gene id: 9925:MAT1A
uniprot id: A0A452E082
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9925:DBH
gene id: 9925:DBH
uniprot id: A0A452EPP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Conversion of dopamine to noradrenaline.
messages: Homotetramer; composed of two disulfide-linked dimers.
messages: chromaffin granule lumen
messages: chromaffin granule membrane
messages: secretory vesicle lumen
messages: secretory vesicle membrane

9925:MYC
gene id: 9925:MYC
uniprot id: A0A452EI51
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.
messages: nucleolus
messages: nucleoplasm

9925:FUT8
gene id: 9925:FUT8
uniprot id: A0A452DUT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9925:SRP68
gene id: 9925:SRP68
uniprot id: A0A452E1M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9925:FOXF1
gene id: 9925:FOXF1
uniprot id: A0A452F7I7
names: Subcellular Location Annotation
messages: Nucleus

9925:RANGRF
gene id: 9925:RANGRF
uniprot id: A0A452G0E7
uniprot id: A0A8C2S790
names: Similarity
messages: Belongs to the MOG1 family.

9925:FKBP5
gene id: 9925:FKBP5
uniprot id: A0A452EN21
names: Subcellular Location Annotation
messages: Nucleus

9925:NPM3
gene id: 9925:NPM3
uniprot id: A0A452FWC3
names: Similarity
messages: Belongs to the nucleoplasmin family.

9925:LOC102168691
gene id: 9925:LOC102168691
uniprot id: A0A452ENX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9925:ADHFE1
gene id: 9925:ADHFE1
uniprot id: A0A8C2NLP9
uniprot id: A0A8C2NLX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9925:LOC102174676
gene id: 9925:LOC102174676
uniprot id: A0A452DPB7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CCNA2
gene id: 9925:CCNA2
uniprot id: A0A452F227
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9925:ASPHD2
gene id: 9925:ASPHD2
uniprot id: A0A452FZX4
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9925:WHAMM
gene id: 9925:WHAMM
uniprot id: A0A452EN09
names: Subcellular Location Annotation
messages: Membrane

9925:MASTL
gene id: 9925:MASTL
uniprot id: A0A452E9R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Nucleus
messages: centrosome

9925:CAMLG
gene id: 9925:CAMLG
uniprot id: A0A452DRW5
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9925:AK2
gene id: 9925:AK2
uniprot id: A0A452FVS1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9925:SPAST
gene id: 9925:SPAST
uniprot id: A0A452ER88
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

9925:INSRR
gene id: 9925:INSRR
uniprot id: A0A452FCS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9925:HR
gene id: 9925:HR
uniprot id: A0A452FZ90
names: Subcellular Location Annotation
messages: Nucleus

9925:SPI1
gene id: 9925:SPI1
uniprot id: A0A452FAZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:POLR2L
gene id: 9925:POLR2L
uniprot id: A0A452FR10
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

9925:LOC102172356
gene id: 9925:LOC102172356
uniprot id: A0A452DR83
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:TSHZ1
gene id: 9925:TSHZ1
uniprot id: A0A452EVF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9925:CLK4
gene id: 9925:CLK4
uniprot id: A0A452F9Z6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:TNNI3
gene id: 9925:TNNI3
uniprot id: I6V1W5
names: Function
names: Similarity
messages: Belongs to the troponin I family.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9925:LOC102180465
gene id: 9925:LOC102180465
uniprot id: A0A452F449
names: Subcellular Location Annotation
messages: Secreted

9925:NKX2-6
gene id: 9925:NKX2-6
uniprot id: A0A452FST8
names: Subcellular Location Annotation
messages: Nucleus

9925:CLTB
gene id: 9925:CLTB
uniprot id: A0A452F3N4
uniprot id: A0A452F3Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9925:CMC2
gene id: 9925:CMC2
uniprot id: A0A452EH45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9925:ATP5F1
gene id: 9925:ATP5F1
uniprot id: A0A452EBH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9925:SLAIN2
gene id: 9925:SLAIN2
uniprot id: A0A452EGH6
uniprot id: A0A452EGH9
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9925:MAP28
gene id: 9925:MAP28
uniprot id: Q9XSQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9925:SMAD5
gene id: 9925:SMAD5
uniprot id: A0A452EMT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9925:IRF2BP2
gene id: 9925:IRF2BP2
uniprot id: A0A452E944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9925:MC2R
gene id: 9925:MC2R
uniprot id: A0A452DS38
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

9925:ADK
gene id: 9925:ADK
uniprot id: A0A452DJZ4
uniprot id: A0A452DJZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9925:LOC102172829
gene id: 9925:LOC102172829
uniprot id: A0A452EBD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RIN3
gene id: 9925:RIN3
uniprot id: A0A452ESG1
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9925:SLC39A1
gene id: 9925:SLC39A1
uniprot id: A0A452E9K3
uniprot id: F4ZW67
names: Subcellular Location Annotation
messages: Membrane

9925:TM4SF18
gene id: 9925:TM4SF18
uniprot id: A0A8C2N742
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9925:GRP
gene id: 9925:GRP
uniprot id: A0A452E8M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.
messages: Secreted
messages: neuron projection
messages: secretory vesicle lumen

9925:SMDT1
gene id: 9925:SMDT1
uniprot id: A0A452FFA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9925:TGS1
gene id: 9925:TGS1
uniprot id: A0A452EIV0
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9925:MOG
gene id: 9925:MOG
uniprot id: A0A452E9B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9925:TAF12
gene id: 9925:TAF12
uniprot id: A0A452DNQ3
uniprot id: A0A8C2NC12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9925:LIN7A
gene id: 9925:LIN7A
uniprot id: A0A452DP90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9925:SPTBN1
gene id: 9925:SPTBN1
uniprot id: A0A452ENG9
uniprot id: A0A452EPK3
names: Similarity
messages: Belongs to the spectrin family.

9925:TBPL1
gene id: 9925:TBPL1
uniprot id: A0A452DSG9
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9925:GTPBP8
gene id: 9925:GTPBP8
uniprot id: A0A452G0G5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9925:RPAP2
gene id: 9925:RPAP2
uniprot id: A0A452F9W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

9925:CPNE8
gene id: 9925:CPNE8
uniprot id: A0A452G7D8
names: Similarity
messages: Belongs to the copine family.

9925:SLC35E1
gene id: 9925:SLC35E1
uniprot id: A0A452DWV3
names: Subcellular Location Annotation
messages: Membrane

9925:AGTR1
gene id: 9925:AGTR1
uniprot id: A0A452E8A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

9925:DTD1
gene id: 9925:DTD1
uniprot id: A0A452G089
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

9925:ALX3
gene id: 9925:ALX3
uniprot id: A0A452G5Q5
names: Subcellular Location Annotation
messages: Nucleus

9925:ATXN1L
gene id: 9925:ATXN1L
uniprot id: A0A452E924
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9925:GTDC1
gene id: 9925:GTDC1
uniprot id: A0A452FPS7
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

9925:MTNR1A
gene id: 9925:MTNR1A
uniprot id: A0A452EXJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9925:VPS11
gene id: 9925:VPS11
uniprot id: A0A452ET33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9925:LOC102182511
gene id: 9925:LOC102182511
uniprot id: A0A452E737
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9925:SLC25A48
gene id: 9925:SLC25A48
uniprot id: A0A452ED82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:MANEAL
gene id: 9925:MANEAL
uniprot id: A0A452F1P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:SERPINC1
gene id: 9925:SERPINC1
uniprot id: A0A452E4U5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9925:SOX4
gene id: 9925:SOX4
uniprot id: A0A452EGG9
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102173738
gene id: 9925:LOC102173738
uniprot id: A0A452EBE1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.

9925:MYSM1
gene id: 9925:MYSM1
uniprot id: A0A452DTX7
names: Similarity
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.

9925:PIWIL2
gene id: 9925:PIWIL2
uniprot id: A0A452FR21
names: Similarity
messages: Belongs to the argonaute family.

9925:HK1
gene id: 9925:HK1
uniprot id: A0A452DLT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9925:VPS33B
gene id: 9925:VPS33B
uniprot id: A0A452EH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9925:CLCN3
gene id: 9925:CLCN3
uniprot id: A0A452F8Z6
uniprot id: A0A452F939
uniprot id: A0A452F962
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9925:LOC102184973
gene id: 9925:LOC102184973
uniprot id: A0A452E8L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SCUBE2
gene id: 9925:SCUBE2
uniprot id: A0A452F0T4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:LIPT2
gene id: 9925:LIPT2
uniprot id: A0A452FVQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

9925:ELL2
gene id: 9925:ELL2
uniprot id: A0A452DXN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9925:BRAF
gene id: 9925:BRAF
uniprot id: A0A452F5E2
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9925:GEM
gene id: 9925:GEM
uniprot id: A0A290Y5J1
uniprot id: A0A452DXG1
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9925:CCDC90B
gene id: 9925:CCDC90B
uniprot id: A0A452FRV6
names: Similarity
messages: Belongs to the CCDC90 family.

9925:ADAM9
gene id: 9925:ADAM9
uniprot id: A0A452FAF5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:POLG
gene id: 9925:POLG
uniprot id: A0A452E655
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

9925:LOC102173552
gene id: 9925:LOC102173552
uniprot id: A0A452F9R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9925:P4HA1
gene id: 9925:P4HA1
uniprot id: A0A452EJ18
uniprot id: A0A452EJK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9925:KDELC1
gene id: 9925:KDELC1
uniprot id: A0A452FYZ5
names: Similarity
messages: Belongs to the KDELC family.

9925:TNFAIP3
gene id: 9925:TNFAIP3
uniprot id: A0A452FI75
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:NDRG1
gene id: 9925:NDRG1
uniprot id: A0A452ET94
names: Similarity
messages: Belongs to the NDRG family.

9925:LOC102174578
gene id: 9925:LOC102174578
uniprot id: A0A8C2RWA2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:SGCG
gene id: 9925:SGCG
uniprot id: A0A452E5X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

9925:PTPRZ1
gene id: 9925:PTPRZ1
uniprot id: A0A452EZJ5
uniprot id: A0A452EZP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9925:EXTL2
gene id: 9925:EXTL2
uniprot id: A0A452ET21
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LOC102179739
gene id: 9925:LOC102179739
uniprot id: A0A452DNM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CRIPT
gene id: 9925:CRIPT
uniprot id: A0A452FZI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

9925:HMGN1
gene id: 9925:HMGN1
uniprot id: A0A452DQR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9925:INSIG1
gene id: 9925:INSIG1
uniprot id: I1WZP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9925:FXYD5
gene id: 9925:FXYD5
uniprot id: A0A452G9T5
names: Similarity
messages: Belongs to the FXYD family.

9925:CDKN2AIPNL
gene id: 9925:CDKN2AIPNL
uniprot id: A0A452GB87
names: Similarity
messages: Belongs to the CARF family.

9925:PDE4A
gene id: 9925:PDE4A
uniprot id: A0A452FD65
uniprot id: A0A8C2NK15
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:MARK1
gene id: 9925:MARK1
uniprot id: A0A452F5X9
uniprot id: A0A452F6G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9925:FAM135A
gene id: 9925:FAM135A
uniprot id: A0A452EHA0
names: Similarity
messages: Belongs to the FAM135 family.

9925:MARVELD3
gene id: 9925:MARVELD3
uniprot id: A0A452G471
names: Subcellular Location Annotation
messages: Membrane

9925:HEXA
gene id: 9925:HEXA
uniprot id: A0A452FCM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9925:SDF4
gene id: 9925:SDF4
uniprot id: A0A452EHS7
uniprot id: A5YVD9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Binds calcium via its EF-hands.
messages: Golgi apparatus lumen
messages: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.

9925:HESX1
gene id: 9925:HESX1
uniprot id: A0A452FUH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

9925:KCNE2
gene id: 9925:KCNE2
uniprot id: A0A452DSG8
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9925:HOXA2
gene id: 9925:HOXA2
uniprot id: A0A452FXW8
names: Subcellular Location Annotation
messages: Nucleus

9925:ZDHHC6
gene id: 9925:ZDHHC6
uniprot id: A0A452EMW2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:LOC102175526
gene id: 9925:LOC102175526
uniprot id: A0A452G5C0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9925:LOC102173489
gene id: 9925:LOC102173489
uniprot id: A0A452F7A7
names: Similarity
messages: Belongs to the DDI1 family.

9925:SLC5A6
gene id: 9925:SLC5A6
uniprot id: A0A452FVB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9925:SNX1
gene id: 9925:SNX1
uniprot id: A0A452FL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9925:AMZ2
gene id: 9925:AMZ2
uniprot id: A0A452FVF4
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9925:LOC102173106
gene id: 9925:LOC102173106
uniprot id: A0A452DNY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LHPP
gene id: 9925:LHPP
uniprot id: A0A452EXK5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9925:RPL15
gene id: 9925:RPL15
uniprot id: A0A452ELX4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9925:CACNG2
gene id: 9925:CACNG2
uniprot id: A0A452E8D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

9925:FXR1
gene id: 9925:FXR1
uniprot id: A0A452EYY2
uniprot id: A0A452EZC4
names: Similarity
messages: Belongs to the FMR1 family.

9925:LOC102185579
gene id: 9925:LOC102185579
uniprot id: A0A452GBI5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:RRP1B
gene id: 9925:RRP1B
uniprot id: A0A452FJI3
uniprot id: A0A8C2NLT6
names: Similarity
messages: Belongs to the RRP1 family.

9925:PDLIM3
gene id: 9925:PDLIM3
uniprot id: A0A452G1F7
uniprot id: A0A452G242
names: Subcellular Location Annotation
messages: Z line

9925:MMP20
gene id: 9925:MMP20
uniprot id: A0A452G6Y7
names: Similarity
messages: Belongs to the peptidase M10A family.

9925:SIN3A
gene id: 9925:SIN3A
uniprot id: A0A452FFS1
names: Subcellular Location Annotation
messages: Nucleus

9925:CCS
gene id: 9925:CCS
uniprot id: A0A452ES54
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
messages: Nucleus

9925:CCL22
gene id: 9925:CCL22
uniprot id: A0A452FQ04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:LOC102168235
gene id: 9925:LOC102168235
uniprot id: A0A452DX44
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9925:CHURC1
gene id: 9925:CHURC1
uniprot id: A0A452EDH9
names: Similarity
messages: Belongs to the Churchill family.

9925:LOC102183711
gene id: 9925:LOC102183711
uniprot id: A0A452E0N1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PKP4
gene id: 9925:PKP4
uniprot id: A0A452F4V1
uniprot id: A0A452F522
uniprot id: A0A8C2NJG4
names: Similarity
messages: Belongs to the beta-catenin family.

9925:MRPL17
gene id: 9925:MRPL17
uniprot id: A0A452ESA4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9925:WFIKKN1
gene id: 9925:WFIKKN1
uniprot id: A0A452E4Z1
names: Similarity
messages: Belongs to the WFIKKN family.

9925:FAM213A
gene id: 9925:FAM213A
uniprot id: A0A452DL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

9925:AGAP1
gene id: 9925:AGAP1
uniprot id: A0A452ERT0
uniprot id: A0A452ERZ7
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9925:SLC25A27
gene id: 9925:SLC25A27
uniprot id: A0A452FJ73
uniprot id: A0A8C2RHN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:DSG2
gene id: 9925:DSG2
uniprot id: A0A452EUS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9925:GRAP
gene id: 9925:GRAP
uniprot id: A0A452DQJ1
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9925:DBX1
gene id: 9925:DBX1
uniprot id: A0A452FSI2
names: Subcellular Location Annotation
messages: Nucleus

9925:SCN2A
gene id: 9925:SCN2A
uniprot id: A0A452FU15
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9925:EIF4A2
gene id: 9925:EIF4A2
uniprot id: A0A452EBN6
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9925:KCNJ2
gene id: 9925:KCNJ2
uniprot id: A0A452DN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

9925:DPH3
gene id: 9925:DPH3
uniprot id: A0A452EVU6
names: Similarity
messages: Belongs to the DPH3 family.

9925:DCP1B
gene id: 9925:DCP1B
uniprot id: A0A452EJY4
names: Similarity
messages: Belongs to the DCP1 family.

9925:TLR10
gene id: 9925:TLR10
uniprot id: A0A452E236
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9925:TRPC1
gene id: 9925:TRPC1
uniprot id: A0A452FEU2
uniprot id: A0A452FFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9925:NMNAT2
gene id: 9925:NMNAT2
uniprot id: A0A452FLC2
uniprot id: A0A8C2SM35
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9925:HLX
gene id: 9925:HLX
uniprot id: A0A452EK78
names: Subcellular Location Annotation
messages: Nucleus

9925:NACC1
gene id: 9925:NACC1
uniprot id: A0A452FUV1
names: Subcellular Location Annotation
messages: Nucleus

9925:HPD
gene id: 9925:HPD
uniprot id: A0A8C2SA42
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9925:TP53RK
gene id: 9925:TP53RK
uniprot id: A0A452G6K2
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

9925:YY1
gene id: 9925:YY1
uniprot id: A0A452EH31
names: Similarity
messages: Belongs to the YY transcription factor family.

9925:RGMB
gene id: 9925:RGMB
uniprot id: A0A452FNF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9925:GABARAPL2
gene id: 9925:GABARAPL2
uniprot id: G3EHG8
names: Similarity
messages: Belongs to the ATG8 family.

9925:LOC102177766
gene id: 9925:LOC102177766
uniprot id: A0A452E3X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EIF4E2
gene id: 9925:EIF4E2
uniprot id: A0A452FJ66
uniprot id: A0A8C2N8Y4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9925:IGFBP6
gene id: 9925:IGFBP6
uniprot id: K9MM29
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:C25H16orf62
gene id: 9925:C25H16orf62
uniprot id: A0A452E925
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS35L family.
messages: Endosome

9925:CSNK1G3
gene id: 9925:CSNK1G3
uniprot id: A0A452G202
uniprot id: A0A452G207
uniprot id: A0A452G263
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9925:ESRRB
gene id: 9925:ESRRB
uniprot id: A0A452FQ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9925:BAZ1B
gene id: 9925:BAZ1B
uniprot id: A0A452F8I4
names: Subcellular Location Annotation
messages: Nucleus

9925:XKR7
gene id: 9925:XKR7
uniprot id: A0A452GA50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9925:FAM32A
gene id: 9925:FAM32A
uniprot id: A0A452FG54
names: Similarity
messages: Belongs to the FAM32 family.

9925:RBL2
gene id: 9925:RBL2
uniprot id: A0A452G0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9925:CNN1
gene id: 9925:CNN1
uniprot id: A0A452FAT1
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9925:ANAPC16
gene id: 9925:ANAPC16
uniprot id: A0A452EUZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9925:LOC102175174
gene id: 9925:LOC102175174
uniprot id: A0A452DKU2
names: Subcellular Location Annotation
messages: Nucleus

9925:ACTR1B
gene id: 9925:ACTR1B
uniprot id: A0A452FL06
names: Similarity
messages: Belongs to the actin family.

9925:NKX2-5
gene id: 9925:NKX2-5
uniprot id: A0A452F0G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

9925:DCTN6
gene id: 9925:DCTN6
uniprot id: A0A452FFG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9925:LOC102191494
gene id: 9925:LOC102191494
uniprot id: A0A452E5I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9925:DBT
gene id: 9925:DBT
uniprot id: A0A452EV54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9925:CHST8
gene id: 9925:CHST8
uniprot id: A0A452FA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:SLC39A4
gene id: 9925:SLC39A4
uniprot id: A0A452FA29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9925:CEBPE
gene id: 9925:CEBPE
uniprot id: A0A452FW47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9925:EIF2D
gene id: 9925:EIF2D
uniprot id: A0A452E018
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9925:GTF3C5
gene id: 9925:GTF3C5
uniprot id: A0A452FWN3
uniprot id: A0A452FX53
names: Subcellular Location Annotation
messages: Nucleus

9925:NR2C2
gene id: 9925:NR2C2
uniprot id: A0A452DXZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:BBOX1
gene id: 9925:BBOX1
uniprot id: A0A452ERN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
messages: Cytoplasm

9925:TMEM182
gene id: 9925:TMEM182
uniprot id: A0A452FJJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9925:YME1L1
gene id: 9925:YME1L1
uniprot id: A0A452G9W9
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9925:TLL2
gene id: 9925:TLL2
uniprot id: A0A452DUH1
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PAEP
gene id: 9925:PAEP
uniprot id: P02756
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alternate disulfide bonds occur in equal amounts.
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
messages: Secreted
messages: Synthesized in mammary gland and secreted in milk.
messages: Under physiological conditions beta-lactoglobulin exists as an equilibrium mixture of monomeric and dimeric forms (By similarity). Interaction with LMBR1L is controversial (By similarity).

9925:TMEM233
gene id: 9925:TMEM233
uniprot id: A0A452DS85
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9925:PRKAR2B
gene id: 9925:PRKAR2B
uniprot id: A0A452G3U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9925:LOC108637516
gene id: 9925:LOC108637516
uniprot id: A0A452DT65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

9925:MRPL35
gene id: 9925:MRPL35
uniprot id: A0A452EU88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9925:MEGF10
gene id: 9925:MEGF10
uniprot id: A0A452G2K5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PTPN11
gene id: 9925:PTPN11
uniprot id: A0A452F960
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9925:JPH2
gene id: 9925:JPH2
uniprot id: A0A452G3E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9925:LOC102171661
gene id: 9925:LOC102171661
uniprot id: A0A452FGE5
names: Similarity
messages: Belongs to the serpin family.

9925:TGM7
gene id: 9925:TGM7
uniprot id: A0A452F4K1
uniprot id: A0A452F4P4
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9925:KMT5B
gene id: 9925:KMT5B
uniprot id: A0A452G3F8
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9925:WDR76
gene id: 9925:WDR76
uniprot id: A0A452EBA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9925:NOP16
gene id: 9925:NOP16
uniprot id: A0A452FL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9925:COG8
gene id: 9925:COG8
uniprot id: A0A452FLJ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

9925:HABP4
gene id: 9925:HABP4
uniprot id: A0A452F5C8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:MYOG
gene id: 9925:MYOG
uniprot id: B9VV80
names: Subcellular Location Annotation
messages: Nucleus

9925:PLCD1
gene id: 9925:PLCD1
uniprot id: A0A452ECQ4
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9925:LOC102181743
gene id: 9925:LOC102181743
uniprot id: A0A452F3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9925:NIPBL
gene id: 9925:NIPBL
uniprot id: A0A452E7A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9925:PHAX
gene id: 9925:PHAX
uniprot id: A0A452F8M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

9925:PAIP2
gene id: 9925:PAIP2
uniprot id: A0A452DQI2
names: Similarity
messages: Belongs to the PAIP2 family.

9925:CEP162
gene id: 9925:CEP162
uniprot id: A0A452EFU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

9925:ATP2A3
gene id: 9925:ATP2A3
uniprot id: A0A452F5S7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9925:LOC102186788
gene id: 9925:LOC102186788
uniprot id: A0A452DX47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SPC25
gene id: 9925:SPC25
uniprot id: A0A452FFW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9925:GFOD1
gene id: 9925:GFOD1
uniprot id: A0A8C2S0B0
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9925:LOC102169099
gene id: 9925:LOC102169099
uniprot id: A0A8C2Y2T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TSPAN9
gene id: 9925:TSPAN9
uniprot id: A0A452EJN5
uniprot id: A0A452EJW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:UTP23
gene id: 9925:UTP23
uniprot id: A0A452FB84
names: Subcellular Location Annotation
messages: nucleolus

9925:MANF
gene id: 9925:MANF
uniprot id: A0A452F719
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9925:TARBP2
gene id: 9925:TARBP2
uniprot id: A0A8C2R993
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9925:HOXB8
gene id: 9925:HOXB8
uniprot id: A0A452ERW1
names: Subcellular Location Annotation
messages: Nucleus

9925:PPL
gene id: 9925:PPL
uniprot id: A0A452E9I3
names: Subcellular Location Annotation
messages: cytoskeleton

9925:ING4
gene id: 9925:ING4
uniprot id: A0A452G205
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9925:LOC102183943
gene id: 9925:LOC102183943
uniprot id: A0A452ERU6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ATP6V1G1
gene id: 9925:ATP6V1G1
uniprot id: A0A452ESL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9925:GABRA4
gene id: 9925:GABRA4
uniprot id: A0A452E6Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:TOX4
gene id: 9925:TOX4
uniprot id: A0A452DP67
names: Subcellular Location Annotation
messages: Nucleus

9925:PIK3CG
gene id: 9925:PIK3CG
uniprot id: A0A452E4F8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9925:DNAL4
gene id: 9925:DNAL4
uniprot id: A0A452F6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9925:RPL23
gene id: 9925:RPL23
uniprot id: A0A452EU40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9925:FEV
gene id: 9925:FEV
uniprot id: A0A452EPV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:AMH
gene id: 9925:AMH
uniprot id: A0A452FX46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
messages: Secreted

9925:LOC108636461
gene id: 9925:LOC108636461
uniprot id: A0A452DWN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ADGRF5
gene id: 9925:ADGRF5
uniprot id: A0A452DXP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9925:DNAJB12
gene id: 9925:DNAJB12
uniprot id: A0A452DMB4
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102175187
gene id: 9925:LOC102175187
uniprot id: A0A452FFU9
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

9925:GALK2
gene id: 9925:GALK2
uniprot id: A0A452FHP1
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9925:CDH3
gene id: 9925:CDH3
uniprot id: A0A452E9A1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:MED29
gene id: 9925:MED29
uniprot id: A0A8C2RNP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9925:HSD17B7
gene id: 9925:HSD17B7
uniprot id: A0A452DSV0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9925:EDN2
gene id: 9925:EDN2
uniprot id: A0A452FW37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides.
messages: Secreted

9925:NFKB2
gene id: 9925:NFKB2
uniprot id: A0A452FBW1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:LOC108636616
gene id: 9925:LOC108636616
uniprot id: A0A452DR89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:CSNK1G2
gene id: 9925:CSNK1G2
uniprot id: A0A452EAX9
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9925:LOC108636104
gene id: 9925:LOC108636104
uniprot id: A0A452DUV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PITX2
gene id: 9925:PITX2
uniprot id: A0A0H3XRN2
uniprot id: A0A452E417
uniprot id: A0A452E421
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9925:FERMT2
gene id: 9925:FERMT2
uniprot id: A0A452FVF2
names: Similarity
messages: Belongs to the kindlin family.

9925:PLCB2
gene id: 9925:PLCB2
uniprot id: A0A452DUW1
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9925:KRT40
gene id: 9925:KRT40
uniprot id: A0A452FZW3
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LOC102181391
gene id: 9925:LOC102181391
uniprot id: A0A452DPF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:METTL4
gene id: 9925:METTL4
uniprot id: A0A452DKJ1
uniprot id: A0A8C2RR17
names: Similarity
messages: Belongs to the MT-A70-like family.

9925:SRSF5
gene id: 9925:SRSF5
uniprot id: A0A452EX18
names: Similarity
messages: Belongs to the splicing factor SR family.

9925:SORL1
gene id: 9925:SORL1
uniprot id: A0A452FGN5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9925:HSPA14
gene id: 9925:HSPA14
uniprot id: A0A452FRH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9925:CD36
gene id: 9925:CD36
uniprot id: A0A452G1U2
uniprot id: F8U3U7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

9925:ITGA9
gene id: 9925:ITGA9
uniprot id: A0A452FI26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:NPTX2
gene id: 9925:NPTX2
uniprot id: A0A452ETK0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SEC61A1
gene id: 9925:SEC61A1
uniprot id: A0A452E2D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:FAM45A
gene id: 9925:FAM45A
uniprot id: A0A452FF34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

9925:ESD
gene id: 9925:ESD
uniprot id: A0A452FIG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9925:OSGEPL1
gene id: 9925:OSGEPL1
uniprot id: A0A452FQJ7
uniprot id: A0A8C2RG25
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9925:EPHB2
gene id: 9925:EPHB2
uniprot id: A0A452FQI3
names: Subcellular Location Annotation
messages: Membrane

9925:BRK1
gene id: 9925:BRK1
uniprot id: A0A452F877
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: cytoskeleton

9925:GPATCH1
gene id: 9925:GPATCH1
uniprot id: A0A452FAF1
names: Similarity
messages: Belongs to the GPATCH1 family.

9925:PDPK1
gene id: 9925:PDPK1
uniprot id: A0A452EQ64
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

9925:MRGBP
gene id: 9925:MRGBP
uniprot id: A0A452EMF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

9925:CD74
gene id: 9925:CD74
uniprot id: A0A8C2N5H2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:GJB5
gene id: 9925:GJB5
uniprot id: A0A452E3E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:LOC102175297
gene id: 9925:LOC102175297
uniprot id: A0A452DZ94
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9925:DDX6
gene id: 9925:DDX6
uniprot id: A0A452G600
names: Similarity
messages: Belongs to the DEAD box helicase family.

9925:SLC25A28
gene id: 9925:SLC25A28
uniprot id: A0A452ECQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:CAMK2N2
gene id: 9925:CAMK2N2
uniprot id: A0A452F3N0
names: Similarity
messages: Belongs to the CAMK2N family.

9925:LCORL
gene id: 9925:LCORL
uniprot id: A0A452FBL5
names: Subcellular Location Annotation
messages: Nucleus

9925:POSTN
gene id: 9925:POSTN
uniprot id: A0A452DWM1
uniprot id: A0A452DWP6
uniprot id: A0A452DWX4
uniprot id: A0A452DWX6
names: Subcellular Location Annotation
messages: extracellular matrix

9925:CDS2
gene id: 9925:CDS2
uniprot id: A0A452FIL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9925:LOC102170758
gene id: 9925:LOC102170758
uniprot id: A0A452E307
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:MEOX2
gene id: 9925:MEOX2
uniprot id: A0A452EJ65
names: Subcellular Location Annotation
messages: Nucleus

9925:BORA
gene id: 9925:BORA
uniprot id: A0A452DUX0
names: Similarity
messages: Belongs to the BORA family.

9925:NR4A2
gene id: 9925:NR4A2
uniprot id: A0A452EDZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9925:FAN1
gene id: 9925:FAN1
uniprot id: A0A452FHK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

9925:ADAM15
gene id: 9925:ADAM15
uniprot id: A0A452DS44
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:RPS5
gene id: 9925:RPS5
uniprot id: A0A452F9Y6
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9925:TWSG1
gene id: 9925:TWSG1
uniprot id: A0A452G7M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

9925:RUNX3
gene id: 9925:RUNX3
uniprot id: A0A452FY78
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9925:AP3D1
gene id: 9925:AP3D1
uniprot id: A0A452FXQ1
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9925:LOC102187311
gene id: 9925:LOC102187311
uniprot id: A0A452FUU3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:LOC102183165
gene id: 9925:LOC102183165
uniprot id: A0A452DVB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:STAT6
gene id: 9925:STAT6
uniprot id: A0A8C2Y3F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9925:SLC25A20
gene id: 9925:SLC25A20
uniprot id: A0A452E3X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:TPPP2
gene id: 9925:TPPP2
uniprot id: A0A452DNE8
names: Similarity
messages: Belongs to the TPPP family.

9925:SENP1
gene id: 9925:SENP1
uniprot id: A0A452FIQ0
names: Similarity
messages: Belongs to the peptidase C48 family.

9925:TMEM63C
gene id: 9925:TMEM63C
uniprot id: A0A452FQB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9925:PCSK6
gene id: 9925:PCSK6
uniprot id: A0A452EX27
names: Similarity
messages: Belongs to the peptidase S8 family.

9925:ACSF3
gene id: 9925:ACSF3
uniprot id: A0A452EDD9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:EPHA8
gene id: 9925:EPHA8
uniprot id: A0A452FTC4
names: Subcellular Location Annotation
messages: Membrane

9925:LOC108636544
gene id: 9925:LOC108636544
uniprot id: A0A452DW99
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Monomer.
messages: Secreted

9925:POLR3H
gene id: 9925:POLR3H
uniprot id: A0A452EJ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

9925:ANXA11
gene id: 9925:ANXA11
uniprot id: A0A452DL82
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9925:SSTR2
gene id: 9925:SSTR2
uniprot id: A0A452DWP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9925:BEST2
gene id: 9925:BEST2
uniprot id: A0A452DZ67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9925:EIF3I
gene id: 9925:EIF3I
uniprot id: A0A452FJF7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9925:SIM2
gene id: 9925:SIM2
uniprot id: A0A452FXM0
names: Subcellular Location Annotation
messages: Nucleus

9925:CCNT1
gene id: 9925:CCNT1
uniprot id: Q8MJC2
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

9925:TOP3A
gene id: 9925:TOP3A
uniprot id: A0A452EK54
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9925:LOC102170264
gene id: 9925:LOC102170264
uniprot id: A0A8C2PIL7
names: Similarity
messages: Belongs to the KRTAP type 3 family.

9925:MAP6D1
gene id: 9925:MAP6D1
uniprot id: A0A452F0K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

9925:DVL3
gene id: 9925:DVL3
uniprot id: A0A452EF16
names: Similarity
messages: Belongs to the DSH family.

9925:NPRL2
gene id: 9925:NPRL2
uniprot id: A0A452EXQ6
names: Similarity
messages: Belongs to the NPR2 family.

9925:POP4
gene id: 9925:POP4
uniprot id: A0A452EWZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9925:TMEM159
gene id: 9925:TMEM159
uniprot id: A0A452FIX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9925:LMNB1
gene id: 9925:LMNB1
uniprot id: A0A452EHE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9925:PGAP1
gene id: 9925:PGAP1
uniprot id: A0A452F4I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9925:MKI67
gene id: 9925:MKI67
uniprot id: A0A452FUY8
names: Subcellular Location Annotation
messages: Nucleus

9925:GAL3ST3
gene id: 9925:GAL3ST3
uniprot id: A0A452FTX6
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9925:ISM1
gene id: 9925:ISM1
uniprot id: A0A452E9N3
uniprot id: A0A452E9V9
names: Similarity
messages: Belongs to the isthmin family.

9925:DUOXA2
gene id: 9925:DUOXA2
uniprot id: A0A452E2R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9925:EIF1
gene id: 9925:EIF1
uniprot id: A0A452FC30
names: Similarity
messages: Belongs to the SUI1 family.

9925:CAMK1D
gene id: 9925:CAMK1D
uniprot id: A0A452DU38
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:RC3H1
gene id: 9925:RC3H1
uniprot id: A0A452DP18
names: Subcellular Location Annotation
messages: P-body

9925:MAN2B1
gene id: 9925:MAN2B1
uniprot id: J7F5B7
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9925:SSH3
gene id: 9925:SSH3
uniprot id: A0A8C2RR13
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9925:NKAIN2
gene id: 9925:NKAIN2
uniprot id: A0A8C2RS27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9925:PCYOX1
gene id: 9925:PCYOX1
uniprot id: A0A452F756
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9925:DPEP3
gene id: 9925:DPEP3
uniprot id: A0A452G4L4
names: Subcellular Location Annotation
messages: Membrane

9925:QPCTL
gene id: 9925:QPCTL
uniprot id: A0A452GBI6
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9925:IRF2BPL
gene id: 9925:IRF2BPL
uniprot id: A0A452E5Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9925:IGHMBP2
gene id: 9925:IGHMBP2
uniprot id: A0A452E9K6
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

9925:MRPS25
gene id: 9925:MRPS25
uniprot id: A0A452E1X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9925:LOC102173384
gene id: 9925:LOC102173384
uniprot id: A0A059U1E3
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9925:LOC102188265
gene id: 9925:LOC102188265
uniprot id: A0A452DL87
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:TLR1
gene id: 9925:TLR1
uniprot id: F1CGU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9925:CSRNP1
gene id: 9925:CSRNP1
uniprot id: A0A452FLI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9925:B4GALT4
gene id: 9925:B4GALT4
uniprot id: A0A452FBR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9925:JAK3
gene id: 9925:JAK3
uniprot id: A0A452DZ12
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9925:ELP5
gene id: 9925:ELP5
uniprot id: A0A452E4B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9925:HMGB2
gene id: 9925:HMGB2
uniprot id: A0A452E6V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9925:LOC102184907
gene id: 9925:LOC102184907
uniprot id: A0A452G1E5
uniprot id: A0A452G218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9925:ARSB
gene id: 9925:ARSB
uniprot id: A0A452DMI1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9925:C8H9orf3
gene id: 9925:C8H9orf3
uniprot id: A0A452E9Q5
names: Similarity
messages: Belongs to the peptidase M1 family.

9925:ACOT8
gene id: 9925:ACOT8
uniprot id: A0A452F0N9
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9925:KCNK3
gene id: 9925:KCNK3
uniprot id: A0A452G8X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:CCM2L
gene id: 9925:CCM2L
uniprot id: A0A452FAI4
names: Similarity
messages: Belongs to the CCM2 family.

9925:LOC108634238
gene id: 9925:LOC108634238
uniprot id: A0A0A0U6N1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9925:PIK3C2A
gene id: 9925:PIK3C2A
uniprot id: A0A452ENZ1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9925:SDPR
gene id: 9925:SDPR
uniprot id: A0A452FAV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9925:BECN2
gene id: 9925:BECN2
uniprot id: A0A8C2RMV6
names: Similarity
messages: Belongs to the beclin family.

9925:SUMO3
gene id: 9925:SUMO3
uniprot id: A0A452ESL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9925:RPS26
gene id: 9925:RPS26
uniprot id: A0A452ELE6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9925:PPP2R2C
gene id: 9925:PPP2R2C
uniprot id: A0A452EVG4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9925:FOXN2
gene id: 9925:FOXN2
uniprot id: A0A452G440
names: Subcellular Location Annotation
messages: Nucleus

9925:LRRC8A
gene id: 9925:LRRC8A
uniprot id: A0A452DP49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9925:FBXO31
gene id: 9925:FBXO31
uniprot id: A0A452EDF3
uniprot id: A0A452EEB9
names: Similarity
names: Subunit
messages: Belongs to the FBXO31 family.
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

9925:TNFRSF1A
gene id: 9925:TNFRSF1A
uniprot id: A0A452EDJ5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:SLC2A1
gene id: 9925:SLC2A1
uniprot id: I0BWL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane
messages: Photoreceptor inner segment

9925:INPP4B
gene id: 9925:INPP4B
uniprot id: A0A452FAX4
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9925:FLAD1
gene id: 9925:FLAD1
uniprot id: A0A452G2N4
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9925:DDX59
gene id: 9925:DDX59
uniprot id: A0A452EME1
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

9925:CXCR1
gene id: 9925:CXCR1
uniprot id: A0A452EAF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:IL15
gene id: 9925:IL15
uniprot id: A0A452FXZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9925:MBOAT4
gene id: 9925:MBOAT4
uniprot id: A0A452DM95
names: Subcellular Location Annotation
messages: Membrane

9925:ABCG5
gene id: 9925:ABCG5
uniprot id: A0A452FXD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9925:LOC108636629
gene id: 9925:LOC108636629
uniprot id: A0A452E2N8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Monomer.
messages: Secreted

9925:ZC2HC1C
gene id: 9925:ZC2HC1C
uniprot id: A0A452G591
names: Similarity
messages: Belongs to the ZC2HC1 family.

9925:MYB
gene id: 9925:MYB
uniprot id: A0A452E252
uniprot id: A0A8C2R9N5
uniprot id: A0A8C2R9U4
names: Subcellular Location Annotation
messages: Nucleus

9925:TPST1
gene id: 9925:TPST1
uniprot id: A0A452FDP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9925:LOC102190909
gene id: 9925:LOC102190909
uniprot id: A0A452FKV2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:TULP3
gene id: 9925:TULP3
uniprot id: A0A452G8R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9925:SESN2
gene id: 9925:SESN2
uniprot id: A0A452FUJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9925:SPEN
gene id: 9925:SPEN
uniprot id: A0A452G1G8
names: Similarity
messages: Belongs to the RRM Spen family.

9925:KCNT2
gene id: 9925:KCNT2
uniprot id: A0A452EQC9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:TMEM186
gene id: 9925:TMEM186
uniprot id: A0A8C2R2U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9925:LOC102175865
gene id: 9925:LOC102175865
uniprot id: A0A452EIQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CFD
gene id: 9925:CFD
uniprot id: A0A452F6V7
names: Function
messages: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

9925:LOC102172545
gene id: 9925:LOC102172545
uniprot id: A0A452DQ37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:THBS4
gene id: 9925:THBS4
uniprot id: A0A452FZ69
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LPCAT1
gene id: 9925:LPCAT1
uniprot id: A0A452DY95
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9925:LOC102168753
gene id: 9925:LOC102168753
uniprot id: A0A452DM68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:APMAP
gene id: 9925:APMAP
uniprot id: A0A452EFA5
names: Similarity
messages: Belongs to the strictosidine synthase family.

9925:HBBC
gene id: 9925:HBBC
uniprot id: P02078
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.
messages: This type of beta-C chain is found when anemia has been experimentally produced.

9925:FMO4
gene id: 9925:FMO4
uniprot id: A0A452FY71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:SLC6A19
gene id: 9925:SLC6A19
uniprot id: A0A452DZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9925:RSBN1
gene id: 9925:RSBN1
uniprot id: A0A8C2RC24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9925:RNF146
gene id: 9925:RNF146
uniprot id: A0A452FPC5
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9925:NAIF1
gene id: 9925:NAIF1
uniprot id: A0A452EGL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

9925:LHX1
gene id: 9925:LHX1
uniprot id: A0A452FM31
names: Subcellular Location Annotation
messages: Nucleus

9925:NLE1
gene id: 9925:NLE1
uniprot id: A0A452EDE5
names: Subcellular Location Annotation
messages: nucleolus

9925:FOXQ1
gene id: 9925:FOXQ1
uniprot id: A0A452DNW4
names: Subcellular Location Annotation
messages: Nucleus

9925:HM13
gene id: 9925:HM13
uniprot id: A0A452GAF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9925:ZNF706
gene id: 9925:ZNF706
uniprot id: A0A452DTV1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:NR5A2
gene id: 9925:NR5A2
uniprot id: A0A452EDC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9925:IRF6
gene id: 9925:IRF6
uniprot id: A0A452EQT2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:ST3GAL3
gene id: 9925:ST3GAL3
uniprot id: A0A452G1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:ATXN3
gene id: 9925:ATXN3
uniprot id: A0A452ELE0
uniprot id: A0A8C2PE97
names: Subcellular Location Annotation
messages: Nucleus

9925:NFIA
gene id: 9925:NFIA
uniprot id: A0A452E7P0
uniprot id: A0A452E815
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9925:SMARCD3
gene id: 9925:SMARCD3
uniprot id: A0A452G138
names: Similarity
messages: Belongs to the SMARCD family.

9925:LOC102180781
gene id: 9925:LOC102180781
uniprot id: A0A452DLZ4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MLH3
gene id: 9925:MLH3
uniprot id: A0A452E1B6
uniprot id: A0A452E1C2
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9925:FGF17
gene id: 9925:FGF17
uniprot id: A0A8C2P0Z0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:LOC102187515
gene id: 9925:LOC102187515
uniprot id: A0A452EFG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9925:LOC102177244
gene id: 9925:LOC102177244
uniprot id: A0A452DSL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9925:LOC102173131
gene id: 9925:LOC102173131
uniprot id: P79153
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Interacts with FDX1/adrenodoxin.
messages: Mitochondrion inner membrane

9925:LOC106501751
gene id: 9925:LOC106501751
uniprot id: A0A452EU67
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9925:ALDH1L2
gene id: 9925:ALDH1L2
uniprot id: A0A452FAC4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9925:DIMT1
gene id: 9925:DIMT1
uniprot id: G8JEA9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9925:S100A16
gene id: 9925:S100A16
uniprot id: A0A452G7N6
names: Similarity
messages: Belongs to the S-100 family.

9925:SBDS
gene id: 9925:SBDS
uniprot id: A0A452G9T7
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9925:FAM221A
gene id: 9925:FAM221A
uniprot id: A0A452E3K9
uniprot id: A0A452E3N6
names: Similarity
messages: Belongs to the FAM221 family.

9925:SLC2A10
gene id: 9925:SLC2A10
uniprot id: A0A452DM77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane

9925:MRTO4
gene id: 9925:MRTO4
uniprot id: A0A452EN78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9925:LOC102187866
gene id: 9925:LOC102187866
uniprot id: A0A452E316
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:OLFML3
gene id: 9925:OLFML3
uniprot id: A0A452G3W0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:CRYL1
gene id: 9925:CRYL1
uniprot id: A0A452FC66
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9925:C7H19orf70
gene id: 9925:C7H19orf70
uniprot id: A0A452G0R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9925:NEK9
gene id: 9925:NEK9
uniprot id: A0A452FPB7
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9925:LSM12
gene id: 9925:LSM12
uniprot id: A0A452F456
names: Similarity
messages: Belongs to the LSM12 family.

9925:ADGRA1
gene id: 9925:ADGRA1
uniprot id: A0A452F7M9
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102188826
gene id: 9925:LOC102188826
uniprot id: A0A452FHX7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:OGDH
gene id: 9925:OGDH
uniprot id: A0A452DTD2
uniprot id: A0A452DTF2
uniprot id: A0A452DTJ5
uniprot id: A0A452DTL0
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9925:LOC102182293
gene id: 9925:LOC102182293
uniprot id: A0A452EIY8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NEMP1
gene id: 9925:NEMP1
uniprot id: A0A452ES74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9925:DDX55
gene id: 9925:DDX55
uniprot id: A0A452FE04
names: Similarity
messages: Belongs to the DEAD box helicase family.

9925:C7H5orf24
gene id: 9925:C7H5orf24
uniprot id: A0A452EAX5
names: Similarity
messages: Belongs to the UPF0461 family.

9925:SLC4A10
gene id: 9925:SLC4A10
uniprot id: A0A452GB51
uniprot id: A0A452GBD6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:XPO1
gene id: 9925:XPO1
uniprot id: A0A452F3H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9925:HCK
gene id: 9925:HCK
uniprot id: A0A452FJZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:LOC102185534
gene id: 9925:LOC102185534
uniprot id: A0A452DZB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MANEA
gene id: 9925:MANEA
uniprot id: A0A452EQE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:CCNI
gene id: 9925:CCNI
uniprot id: A0A452EPL9
names: Similarity
messages: Belongs to the cyclin family.

9925:OVOL1
gene id: 9925:OVOL1
uniprot id: A0A452EYC4
names: Subcellular Location Annotation
messages: Nucleus

9925:FAM126B
gene id: 9925:FAM126B
uniprot id: A0A452EVM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9925:LOC102179294
gene id: 9925:LOC102179294
uniprot id: A0A8C2NVG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9925:EML3
gene id: 9925:EML3
uniprot id: A0A452FIX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9925:MAEL
gene id: 9925:MAEL
uniprot id: A0A452G2G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9925:GNL2
gene id: 9925:GNL2
uniprot id: A0A452ERV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9925:ADAMTS15
gene id: 9925:ADAMTS15
uniprot id: A0A452FK00
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:LOC102190811
gene id: 9925:LOC102190811
uniprot id: A0A452FMP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:STX11
gene id: 9925:STX11
uniprot id: A0A452DTX6
names: Similarity
messages: Belongs to the syntaxin family.

9925:LIG4
gene id: 9925:LIG4
uniprot id: A0A452DM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9925:LOC102180749
gene id: 9925:LOC102180749
uniprot id: A0A452G5E5
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9925:CD68
gene id: 9925:CD68
uniprot id: A0A452FT55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9925:SCML4
gene id: 9925:SCML4
uniprot id: A0A452E4Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9925:SUFU
gene id: 9925:SUFU
uniprot id: A0A452FM19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9925:CALHM2
gene id: 9925:CALHM2
uniprot id: A0A452EMK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9925:IGF2BP3
gene id: 9925:IGF2BP3
uniprot id: A0A452G4V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule

9925:ATPAF2
gene id: 9925:ATPAF2
uniprot id: A0A452G7A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9925:DHDDS
gene id: 9925:DHDDS
uniprot id: A0A452EDZ8
names: Similarity
messages: Belongs to the UPP synthase family.

9925:LOC102190717
gene id: 9925:LOC102190717
uniprot id: A0A452EYB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Belongs to the intercrine gamma family.
messages: Secreted

9925:RBM17
gene id: 9925:RBM17
uniprot id: A0A452FSJ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9925:WNT8A
gene id: 9925:WNT8A
uniprot id: A0A452DM85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:MET
gene id: 9925:MET
uniprot id: A0A452G0H2
uniprot id: A0A452G0I2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:PPP1R3C
gene id: 9925:PPP1R3C
uniprot id: A0A452FRK9
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9925:VPS18
gene id: 9925:VPS18
uniprot id: A0A452FYQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9925:CLIP1
gene id: 9925:CLIP1
uniprot id: A0A452FNI0
names: Subcellular Location Annotation
messages: cytoskeleton

9925:PKD1
gene id: 9925:PKD1
uniprot id: A0A452EV73
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:UCN
gene id: 9925:UCN
uniprot id: A0A8C2QW74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9925:STK17B
gene id: 9925:STK17B
uniprot id: A0A452EIV5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:GNGT2
gene id: 9925:GNGT2
uniprot id: A0A452FPU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:ALCAM
gene id: 9925:ALCAM
uniprot id: A0A452FW24
uniprot id: A0A452FWM4
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9925:ELF2
gene id: 9925:ELF2
uniprot id: A0A452F4W1
uniprot id: A0A452F4X3
uniprot id: A0A452F4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:LOC102174652
gene id: 9925:LOC102174652
uniprot id: A0A452DMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102179346
gene id: 9925:LOC102179346
uniprot id: A0A452FFW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9925:SFXN1
gene id: 9925:SFXN1
uniprot id: A0A452FNP4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9925:EOMES
gene id: 9925:EOMES
uniprot id: A0A452FZG8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:CRYBB3
gene id: 9925:CRYBB3
uniprot id: A0A452E101
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9925:HSPA8
gene id: 9925:HSPA8
uniprot id: I6ZQY0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9925:ACLY
gene id: 9925:ACLY
uniprot id: A0A452FSH4
uniprot id: A0A452FSK9
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9925:GCDH
gene id: 9925:GCDH
uniprot id: A0A452DW19
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9925:LOC102176442
gene id: 9925:LOC102176442
uniprot id: A0A452DU47
names: Similarity
messages: Belongs to the globin family.

9925:PIK3IP1
gene id: 9925:PIK3IP1
uniprot id: A0A452DYP0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ILDR2
gene id: 9925:ILDR2
uniprot id: A0A452ENK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9925:LOC102180554
gene id: 9925:LOC102180554
uniprot id: A0A452E2C2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:ABI3
gene id: 9925:ABI3
uniprot id: A0A452G422
names: Similarity
messages: Belongs to the ABI family.

9925:PUS1
gene id: 9925:PUS1
uniprot id: A0A452DLR5
uniprot id: A0A8C2PEZ8
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9925:FAM214A
gene id: 9925:FAM214A
uniprot id: A0A452E3Z1
names: Similarity
messages: Belongs to the FAM214 family.

9925:PDIK1L
gene id: 9925:PDIK1L
uniprot id: A0A452F8N9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:INSM1
gene id: 9925:INSM1
uniprot id: A0A452DNX0
names: Subcellular Location Annotation
messages: Nucleus

9925:KCNJ8
gene id: 9925:KCNJ8
uniprot id: A0A452FU45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9925:LOC102183034
gene id: 9925:LOC102183034
uniprot id: A0A452E4G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ABHD12
gene id: 9925:ABHD12
uniprot id: A0A452FIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:SCFD1
gene id: 9925:SCFD1
uniprot id: A0A452FXC0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9925:GATA5
gene id: 9925:GATA5
uniprot id: A0A452ELD5
names: Subcellular Location Annotation
messages: Nucleus

9925:C15H11orf87
gene id: 9925:C15H11orf87
uniprot id: A0A452E366
names: Subcellular Location Annotation
messages: Membrane

9925:IRF4
gene id: 9925:IRF4
uniprot id: A0A452EYR1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:PLA1A
gene id: 9925:PLA1A
uniprot id: A0A452EDY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9925:VWA2
gene id: 9925:VWA2
uniprot id: A0A452DN98
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:YBEY
gene id: 9925:YBEY
uniprot id: A0A452DW38
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9925:TLR2
gene id: 9925:TLR2
uniprot id: Q0GC71
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
messages: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
messages: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).
messages: Membrane
messages: Membrane raft
messages: The ATG16L1-binding motif mediates interaction with ATG16L1.
messages: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
messages: phagosome membrane

9925:LOC108637981
gene id: 9925:LOC108637981
uniprot id: A0A452DZV6
names: Subcellular Location Annotation
messages: Secreted

9925:NSUN4
gene id: 9925:NSUN4
uniprot id: A0A452FWY3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9925:PPP2R2A
gene id: 9925:PPP2R2A
uniprot id: A0A452DV16
uniprot id: A0A452DV54
uniprot id: A0A8C2RU48
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9925:LOC102180752
gene id: 9925:LOC102180752
uniprot id: A0A452DQR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SPTLC3
gene id: 9925:SPTLC3
uniprot id: A0A452DVM3
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9925:ACTG1
gene id: 9925:ACTG1
uniprot id: A0A452G8J3
names: Similarity
messages: Belongs to the actin family.

9925:CDK5RAP1
gene id: 9925:CDK5RAP1
uniprot id: A0A452G5T0
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

9925:POU2F1
gene id: 9925:POU2F1
uniprot id: A0A452G945
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9925:PCK1
gene id: 9925:PCK1
uniprot id: A0A452DQ88
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9925:HSPB6
gene id: 9925:HSPB6
uniprot id: A0A452DU61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9925:CHML
gene id: 9925:CHML
uniprot id: A0A452DN11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9925:PENK
gene id: 9925:PENK
uniprot id: A0A452FUC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9925:OVCA2
gene id: 9925:OVCA2
uniprot id: A0A8C2RV39
names: Similarity
messages: Belongs to the LovG family.

9925:FEZ2
gene id: 9925:FEZ2
uniprot id: A0A452FTT5
uniprot id: A0A8C2P0T0
names: Similarity
messages: Belongs to the zygin family.

9925:KCNJ9
gene id: 9925:KCNJ9
uniprot id: A0A452FB73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9925:UBE2D2
gene id: 9925:UBE2D2
uniprot id: A0A8C2PAN9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:LOC102180761
gene id: 9925:LOC102180761
uniprot id: A0A452E5Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:HARS2
gene id: 9925:HARS2
uniprot id: A0A452E1W1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9925:LTB
gene id: 9925:LTB
uniprot id: A0A452F4X4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9925:LOC102168949
gene id: 9925:LOC102168949
uniprot id: A0A452E3F9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:EBF3
gene id: 9925:EBF3
uniprot id: A0A452F963
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9925:CAPG
gene id: 9925:CAPG
uniprot id: A0A452FGV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
messages: Cytoplasm
messages: Melanosome
messages: Nucleus
messages: lamellipodium
messages: ruffle

9925:FRAT1
gene id: 9925:FRAT1
uniprot id: A0A452DX10
names: Similarity
messages: Belongs to the GSK-3-binding protein family.

9925:DUT
gene id: 9925:DUT
uniprot id: A0A452E4D3
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

9925:LOC102173562
gene id: 9925:LOC102173562
uniprot id: A0A452DQ46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9925:MAN1A2
gene id: 9925:MAN1A2
uniprot id: A0A452EEZ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9925:RAD18
gene id: 9925:RAD18
uniprot id: A0A452DWF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9925:NIT1
gene id: 9925:NIT1
uniprot id: A0A452DTV3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9925:ACAP2
gene id: 9925:ACAP2
uniprot id: A0A452FRM0
uniprot id: A0A452FRM8
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9925:LOC102177727
gene id: 9925:LOC102177727
uniprot id: A0A452EDR4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:LOC102181382
gene id: 9925:LOC102181382
uniprot id: A0A452ECM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:PPT2
gene id: 9925:PPT2
uniprot id: A0A452EW18
uniprot id: A0A452EW43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Lysosome

9925:B4GALT3
gene id: 9925:B4GALT3
uniprot id: A0A452F8H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9925:S1PR2
gene id: 9925:S1PR2
uniprot id: A0A452E2Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9925:NAA11
gene id: 9925:NAA11
uniprot id: A0A452E097
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9925:ORC2
gene id: 9925:ORC2
uniprot id: A0A452FJR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9925:STIM1
gene id: 9925:STIM1
uniprot id: A0A452F0Z6
uniprot id: A0A452F137
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:DYNC1LI1
gene id: 9925:DYNC1LI1
uniprot id: A0A452FZ41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9925:SAR1B
gene id: 9925:SAR1B
uniprot id: A0A452FNY5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9925:LOC102189356
gene id: 9925:LOC102189356
uniprot id: A0A452EFL3
uniprot id: O19810
names: Similarity
messages: Belongs to the MHC class II family.

9925:E2F2
gene id: 9925:E2F2
uniprot id: A0A452DU20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9925:UBE4B
gene id: 9925:UBE4B
uniprot id: A0A8C2R5K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9925:NDUFB10
gene id: 9925:NDUFB10
uniprot id: A0A452F225
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

9925:FAM160B2
gene id: 9925:FAM160B2
uniprot id: A0A452FG89
names: Similarity
messages: Belongs to the FHIP family.

9925:NFS1
gene id: 9925:NFS1
uniprot id: A0A452F2X7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9925:PDXK
gene id: 9925:PDXK
uniprot id: A0A452DXH7
names: Similarity
messages: Belongs to the pyridoxine kinase family.

9925:EED
gene id: 9925:EED
uniprot id: A0A452ERM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

9925:MRPL27
gene id: 9925:MRPL27
uniprot id: A0A452DVB9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9925:CXXC4
gene id: 9925:CXXC4
uniprot id: A0A452E3W3
names: Subcellular Location Annotation
messages: Cytoplasm

9925:B3GALT5
gene id: 9925:B3GALT5
uniprot id: A0A452DPF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:LOC102186401
gene id: 9925:LOC102186401
uniprot id: A0A452EFE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LPAR6
gene id: 9925:LPAR6
uniprot id: A0A452FA83
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:PKIB
gene id: 9925:PKIB
uniprot id: A0A452EQV6
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9925:LOC102188781
gene id: 9925:LOC102188781
uniprot id: A0A452FLX5
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9925:NELL2
gene id: 9925:NELL2
uniprot id: A0A452E587
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:GRIK5
gene id: 9925:GRIK5
uniprot id: A0A452G2L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9925:SSX2IP
gene id: 9925:SSX2IP
uniprot id: A0A452G4B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

9925:TCF7
gene id: 9925:TCF7
uniprot id: A0A452GAV5
uniprot id: A0A452GBC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9925:GFRA2
gene id: 9925:GFRA2
uniprot id: A0A452EVB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

9925:LHX5
gene id: 9925:LHX5
uniprot id: A0A452FRA4
names: Subcellular Location Annotation
messages: Nucleus

9925:TBC1D7
gene id: 9925:TBC1D7
uniprot id: A0A8C2S1P6
uniprot id: G1DFS4
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9925:MMRN1
gene id: 9925:MMRN1
uniprot id: A0A452FPQ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:EFS
gene id: 9925:EFS
uniprot id: A0A452G2I5
uniprot id: A0A8C2R7D3
names: Similarity
messages: Belongs to the CAS family.

9925:LOC102168236
gene id: 9925:LOC102168236
uniprot id: A0A452FAD8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9925:CDH11
gene id: 9925:CDH11
uniprot id: A0A452E2V9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:SLC5A12
gene id: 9925:SLC5A12
uniprot id: A0A452EY54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9925:SF3B3
gene id: 9925:SF3B3
uniprot id: A0A452FB80
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102183441
gene id: 9925:LOC102183441
uniprot id: A0A452EZX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9925:MAPKAPK3
gene id: 9925:MAPKAPK3
uniprot id: A0A452EIV8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:DNAJC10
gene id: 9925:DNAJC10
uniprot id: A0A452DPJ4
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.
messages: Endoplasmic reticulum lumen

9925:CIAO1
gene id: 9925:CIAO1
uniprot id: A0A452FMH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9925:RPS23
gene id: 9925:RPS23
uniprot id: A0A452END8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9925:USP3
gene id: 9925:USP3
uniprot id: A0A452FBH1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9925:MAL
gene id: 9925:MAL
uniprot id: A0A452G8N9
names: Subcellular Location Annotation
messages: Membrane

9925:NOC2L
gene id: 9925:NOC2L
uniprot id: A0A452EYW0
names: Similarity
messages: Belongs to the NOC2 family.

9925:CCND2
gene id: 9925:CCND2
uniprot id: A0A452G0W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9925:LOC108633453
gene id: 9925:LOC108633453
uniprot id: A0A452DNW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SUSD6
gene id: 9925:SUSD6
uniprot id: A0A452FH35
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PAXBP1
gene id: 9925:PAXBP1
uniprot id: A0A452FHB9
names: Similarity
messages: Belongs to the GCF family.

9925:SLC35E4
gene id: 9925:SLC35E4
uniprot id: A0A452FC11
names: Subcellular Location Annotation
messages: Membrane

9925:PPP2R5B
gene id: 9925:PPP2R5B
uniprot id: A0A452EZE3
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9925:DUSP10
gene id: 9925:DUSP10
uniprot id: A0A452FE17
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9925:LOC102186918
gene id: 9925:LOC102186918
uniprot id: A0A452EC18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9925:GPR108
gene id: 9925:GPR108
uniprot id: A0A452E177
uniprot id: A0A8C2NWR3
uniprot id: A0A8C2NYT4
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102189128
gene id: 9925:LOC102189128
uniprot id: A0A452DN42
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PTPRN
gene id: 9925:PTPRN
uniprot id: A0A452EK11
uniprot id: A0A8C2NUR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9925:MYOZ2
gene id: 9925:MYOZ2
uniprot id: T1RLJ2
names: Similarity
messages: Belongs to the myozenin family.

9925:AKAP12
gene id: 9925:AKAP12
uniprot id: A0A452EGT7
names: Subcellular Location Annotation
messages: Membrane

9925:LAPTM5
gene id: 9925:LAPTM5
uniprot id: A0A452EIW4
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9925:TNFAIP1
gene id: 9925:TNFAIP1
uniprot id: A0A452ETE2
names: Similarity
messages: Belongs to the BACURD family.

9925:LOC102188304
gene id: 9925:LOC102188304
uniprot id: A0A452E441
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:CAV2
gene id: 9925:CAV2
uniprot id: A0A452EF60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9925:CNOT11
gene id: 9925:CNOT11
uniprot id: A0A452G8P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

9925:MFSD14B
gene id: 9925:MFSD14B
uniprot id: A0A452ESW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9925:PTDSS2
gene id: 9925:PTDSS2
uniprot id: A0A452E468
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LOC102182812
gene id: 9925:LOC102182812
uniprot id: A0A452DWH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102169830
gene id: 9925:LOC102169830
uniprot id: A0A452EAP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9925:GRK2
gene id: 9925:GRK2
uniprot id: A0A452FQF9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9925:NSUN6
gene id: 9925:NSUN6
uniprot id: A0A452ED23
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9925:ZDHHC3
gene id: 9925:ZDHHC3
uniprot id: A0A452EZY6
uniprot id: A0A452EZZ6
uniprot id: A0A8C2XWU0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:SMU1
gene id: 9925:SMU1
uniprot id: A0A452GB05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9925:ZDHHC22
gene id: 9925:ZDHHC22
uniprot id: A0A452EFV0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:GKAP1
gene id: 9925:GKAP1
uniprot id: A0A452G293
uniprot id: A0A452G2A7
names: Similarity
messages: Belongs to the GKAP1 family.

9925:AZIN2
gene id: 9925:AZIN2
uniprot id: A0A8C2N7F9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9925:MLH1
gene id: 9925:MLH1
uniprot id: A0A452EAM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9925:LSM5
gene id: 9925:LSM5
uniprot id: A0A452FYD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9925:CNOT8
gene id: 9925:CNOT8
uniprot id: A0A452ETP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9925:TRIM72
gene id: 9925:TRIM72
uniprot id: A0A8C2PBE5
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle membrane
messages: sarcolemma

9925:PFN4
gene id: 9925:PFN4
uniprot id: A0A452G6P6
names: Similarity
messages: Belongs to the profilin family.

9925:TMEM55A
gene id: 9925:TMEM55A
uniprot id: A0A452EPE7
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9925:SLX4
gene id: 9925:SLX4
uniprot id: A0A452EYF1
uniprot id: A0A8C2R672
names: Similarity
messages: Belongs to the SLX4 family.

9925:GATA2
gene id: 9925:GATA2
uniprot id: A0A452EN07
names: Subcellular Location Annotation
messages: Nucleus

9925:EIF3D
gene id: 9925:EIF3D
uniprot id: A0A452EBA0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9925:TMEM88B
gene id: 9925:TMEM88B
uniprot id: A0A452EML5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9925:AK6
gene id: 9925:AK6
uniprot id: A0A452F332
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9925:GALNT14
gene id: 9925:GALNT14
uniprot id: A0A452EAC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:IRAK1BP1
gene id: 9925:IRAK1BP1
uniprot id: A0A452F3F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9925:LOC102181096
gene id: 9925:LOC102181096
uniprot id: A0A452DZ42
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9925:IPO9
gene id: 9925:IPO9
uniprot id: A0A452EQA5
names: Subcellular Location Annotation
messages: Cytoplasm

9925:CLDN18
gene id: 9925:CLDN18
uniprot id: A0A452FYD3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:PPFIA3
gene id: 9925:PPFIA3
uniprot id: A0A452DWI7
uniprot id: A0A452DWK1
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9925:PRKD1
gene id: 9925:PRKD1
uniprot id: A0A452F161
uniprot id: A0A452F1G8
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9925:PHOSPHO1
gene id: 9925:PHOSPHO1
uniprot id: A0A452FCF6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9925:DNMT3A
gene id: 9925:DNMT3A
uniprot id: A0A452EKG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9925:LOC102177288
gene id: 9925:LOC102177288
uniprot id: A0A452DQX3
names: Similarity
messages: Belongs to the actin family.

9925:GALNT16
gene id: 9925:GALNT16
uniprot id: A0A452FYX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:ACP7
gene id: 9925:ACP7
uniprot id: A0A452F212
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9925:FREM3
gene id: 9925:FREM3
uniprot id: A0A452EUU1
names: Similarity
messages: Belongs to the FRAS1 family.

9925:FOXA1
gene id: 9925:FOXA1
uniprot id: A0A452FTW6
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102182592
gene id: 9925:LOC102182592
uniprot id: A0A452DVI0
names: Similarity
messages: Belongs to the peptidase C48 family.

9925:LOC102184897
gene id: 9925:LOC102184897
uniprot id: A0A452DSH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:IDH2
gene id: 9925:IDH2
uniprot id: A0A452DQC8
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9925:PCNX3
gene id: 9925:PCNX3
uniprot id: A0A8C2S1N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9925:LOC102191547
gene id: 9925:LOC102191547
uniprot id: A0A452ELD1
uniprot id: O18809
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. Stereoselectively catalyzes the formation of the 1R,2S-oxide from naphthalene. Lack activity with other common P450 substrates including 7-ethoxycoumarin.
messages: Endoplasmic reticulum membrane
messages: Lung specific.
messages: Membrane
messages: Microsome membrane

9925:CLEC16A
gene id: 9925:CLEC16A
uniprot id: A0A452EKK4
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9925:ELOVL3
gene id: 9925:ELOVL3
uniprot id: A0A452FET1
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9925:FOXB2
gene id: 9925:FOXB2
uniprot id: A0A452DQM9
names: Subcellular Location Annotation
messages: Nucleus

9925:SPON2
gene id: 9925:SPON2
uniprot id: A0A452F5J8
names: Subcellular Location Annotation
messages: extracellular matrix

9925:WIPI2
gene id: 9925:WIPI2
uniprot id: A0A452G2K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure membrane

9925:KIF23
gene id: 9925:KIF23
uniprot id: A0A452DNG4
uniprot id: A0A452DNH4
uniprot id: A0A452DNH8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:KEF96 p11
gene id: 9925:KEF96_p11
uniprot id: D0VEF6
uniprot id: Q36347
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9925:FSHB
gene id: 9925:FSHB
uniprot id: A0A452FQZ8
uniprot id: D3K2V5
uniprot id: Q8HY83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.
messages: Secreted
messages: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.

9925:CAND1
gene id: 9925:CAND1
uniprot id: A0A452E570
names: Similarity
messages: Belongs to the CAND family.

9925:GLDC
gene id: 9925:GLDC
uniprot id: A0A452FM63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9925:MS4A8
gene id: 9925:MS4A8
uniprot id: A0A452FQR4
names: Similarity
messages: Belongs to the MS4A family.

9925:HMX2
gene id: 9925:HMX2
uniprot id: A0A452G7S4
names: Subcellular Location Annotation
messages: Nucleus

9925:ENTPD8
gene id: 9925:ENTPD8
uniprot id: A0A452EA25
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9925:TMEM14A
gene id: 9925:TMEM14A
uniprot id: A0A452F5T7
names: Similarity
messages: Belongs to the TMEM14 family.

9925:GINS2
gene id: 9925:GINS2
uniprot id: A0A452EV02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9925:INTS10
gene id: 9925:INTS10
uniprot id: A0A452DKX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9925:AVPR1A
gene id: 9925:AVPR1A
uniprot id: A0A452EVU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9925:CDC42EP4
gene id: 9925:CDC42EP4
uniprot id: A0A452E578
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9925:AASDH
gene id: 9925:AASDH
uniprot id: A0A452FN21
uniprot id: A0A452FN36
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:HMBOX1
gene id: 9925:HMBOX1
uniprot id: A0A452DPM7
uniprot id: A0A452DPQ4
uniprot id: A0A452DPT0
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102176173
gene id: 9925:LOC102176173
uniprot id: A0A452E9R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9925:DPP3
gene id: 9925:DPP3
uniprot id: A0A452DQI5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

9925:CRTC2
gene id: 9925:CRTC2
uniprot id: A0A8C2REU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9925:HAO1
gene id: 9925:HAO1
uniprot id: A0A452EQ15
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9925:FANCM
gene id: 9925:FANCM
uniprot id: A0A452EPF1
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

9925:LOC102171954
gene id: 9925:LOC102171954
uniprot id: A0A452DT97
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TBP
gene id: 9925:TBP
uniprot id: A0A452DVV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9925:DOK4
gene id: 9925:DOK4
uniprot id: A0A452G041
uniprot id: A0A8C2PL58
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9925:PIEZO1
gene id: 9925:PIEZO1
uniprot id: A0A452FKM5
uniprot id: A0A452FKW4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIEZO (TC 1.A.75) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:TPK1
gene id: 9925:TPK1
uniprot id: A0A452EDU3
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9925:GREB1
gene id: 9925:GREB1
uniprot id: A0A452F1R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Membrane

9925:FAM172A
gene id: 9925:FAM172A
uniprot id: A0A452DX20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: Nucleus

9925:SYK
gene id: 9925:SYK
uniprot id: A0A452EBK3
uniprot id: A0A452EBP4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9925:SLC25A42
gene id: 9925:SLC25A42
uniprot id: A0A452EZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:S100PBP
gene id: 9925:S100PBP
uniprot id: A0A452F657
names: Subcellular Location Annotation
messages: Nucleus

9925:FOXK2
gene id: 9925:FOXK2
uniprot id: A0A452FGB0
names: Subcellular Location Annotation
messages: Nucleus

9925:TOR1B
gene id: 9925:TOR1B
uniprot id: A0A452EQZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9925:LOC102178029
gene id: 9925:LOC102178029
uniprot id: A0A452FTZ3
names: Similarity
messages: Belongs to the TMEM14 family.

9925:UCK2
gene id: 9925:UCK2
uniprot id: A0A452FUW7
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family.
messages: Homotetramer.

9925:PPARD
gene id: 9925:PPARD
uniprot id: A0A452EIP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:SLC12A7
gene id: 9925:SLC12A7
uniprot id: A0A452F6W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9925:GGPS1
gene id: 9925:GGPS1
uniprot id: A0A452ER44
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9925:FICD
gene id: 9925:FICD
uniprot id: A0A452ESE4
names: Similarity
messages: Belongs to the fic family.

9925:LOC102183891
gene id: 9925:LOC102183891
uniprot id: A0A452DNT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC18B1
gene id: 9925:SLC18B1
uniprot id: A0A452FD32
names: Subcellular Location Annotation
messages: Membrane

9925:SIAH3
gene id: 9925:SIAH3
uniprot id: A0A452FPU1
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9925:MPO
gene id: 9925:MPO
uniprot id: A0A452F0B7
uniprot id: W5U312
names: Cofactor
messages: Binds 1 Ca(2+) ion per monomer.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.

9925:SKIL
gene id: 9925:SKIL
uniprot id: A0A452DY18
names: Similarity
messages: Belongs to the SKI family.

9925:GRIN3A
gene id: 9925:GRIN3A
uniprot id: A0A452G736
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9925:ATP6V1C2
gene id: 9925:ATP6V1C2
uniprot id: A0A452EZQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9925:TMEFF2
gene id: 9925:TMEFF2
uniprot id: A0A452FZT1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LHFPL2
gene id: 9925:LHFPL2
uniprot id: A0A452EK14
names: Subcellular Location Annotation
messages: Membrane

9925:MARVELD1
gene id: 9925:MARVELD1
uniprot id: A0A452F918
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102182331
gene id: 9925:LOC102182331
uniprot id: A0A452DPV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CDH19
gene id: 9925:CDH19
uniprot id: A0A452E1Y4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:BEST1
gene id: 9925:BEST1
uniprot id: A0A452DRR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9925:DDAH1
gene id: 9925:DDAH1
uniprot id: A0A452FZF8
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9925:SMARCA2
gene id: 9925:SMARCA2
uniprot id: A0A452G549
uniprot id: A0A452G579
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9925:STON1
gene id: 9925:STON1
uniprot id: A0A452EFZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasm
messages: May be involved in the endocytic machinery.

9925:LOC102184938
gene id: 9925:LOC102184938
uniprot id: A0A452DVA5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:XRCC3
gene id: 9925:XRCC3
uniprot id: A0A452FG83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

9925:TAS2R4
gene id: 9925:TAS2R4
uniprot id: A0A452E6S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: cilium membrane

9925:VPS41
gene id: 9925:VPS41
uniprot id: A0A452DST1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9925:CCT7
gene id: 9925:CCT7
uniprot id: A0A452FQV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9925:TIMM21
gene id: 9925:TIMM21
uniprot id: A0A452DKZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9925:ST8SIA5
gene id: 9925:ST8SIA5
uniprot id: A0A452FJV5
uniprot id: A0A452FKU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:PSD
gene id: 9925:PSD
uniprot id: A0A452EUS8
names: Subcellular Location Annotation
messages: ruffle membrane

9925:MED13L
gene id: 9925:MED13L
uniprot id: A0A452EZP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:HOGA1
gene id: 9925:HOGA1
uniprot id: A0A452F4W2
uniprot id: A0A8C2PLJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9925:SCGN
gene id: 9925:SCGN
uniprot id: A0A452EQR2
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9925:GBAS
gene id: 9925:GBAS
uniprot id: A0A452F7R4
names: Similarity
messages: Belongs to the NipSnap family.

9925:LOC106503728
gene id: 9925:LOC106503728
uniprot id: A0A452EX53
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9925:RAP2A
gene id: 9925:RAP2A
uniprot id: A0A452ENS9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9925:CPSF3L
gene id: 9925:CPSF3L
uniprot id: A0A452FS82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Nucleus

9925:COG6
gene id: 9925:COG6
uniprot id: A0A452DTQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9925:DMRT2
gene id: 9925:DMRT2
uniprot id: A0A452FCE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9925:POMC
gene id: 9925:POMC
uniprot id: A0A452FYE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Endogenous orexigenic opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

9925:MTFR1
gene id: 9925:MTFR1
uniprot id: A0A452FQV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9925:GPRIN1
gene id: 9925:GPRIN1
uniprot id: A0A452DZ03
names: Function
messages: May be involved in neurite outgrowth.

9925:TSNAX
gene id: 9925:TSNAX
uniprot id: A0A452EAM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9925:UNC45B
gene id: 9925:UNC45B
uniprot id: A0A452F4A3
names: Subcellular Location Annotation
messages: A band
messages: Z line
messages: perinuclear region

9925:SEMA3A
gene id: 9925:SEMA3A
uniprot id: A0A452ER92
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TGFBI
gene id: 9925:TGFBI
uniprot id: A0A452DR78
names: Subcellular Location Annotation
messages: extracellular matrix

9925:ZC3H14
gene id: 9925:ZC3H14
uniprot id: A0A452FQU9
uniprot id: A0A452FQW0
uniprot id: A0A452FR53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

9925:SLC9A1
gene id: 9925:SLC9A1
uniprot id: A0A452FVM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
messages: Membrane

9925:IMPACT
gene id: 9925:IMPACT
uniprot id: A0A452DKQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

9925:IQCG
gene id: 9925:IQCG
uniprot id: A0A452E679
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9925:TFAP2E
gene id: 9925:TFAP2E
uniprot id: A0A452FK36
names: Similarity
messages: Belongs to the AP-2 family.

9925:LOC102182538
gene id: 9925:LOC102182538
uniprot id: A0A3G5ECF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KRTAP type 3 family.
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9925:TM6SF1
gene id: 9925:TM6SF1
uniprot id: A0A452FIL0
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102176495
gene id: 9925:LOC102176495
uniprot id: A0A452DJW6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9925:STK3
gene id: 9925:STK3
uniprot id: A0A452E585
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9925:STARD6
gene id: 9925:STARD6
uniprot id: A0A452ESH0
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9925:LOC102177258
gene id: 9925:LOC102177258
uniprot id: A0A452E455
names: Function
messages: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.

9925:GCG
gene id: 9925:GCG
uniprot id: A0A452FHY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9925:LOC102185056
gene id: 9925:LOC102185056
uniprot id: A0A452EF31
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9925:ADRA2C
gene id: 9925:ADRA2C
uniprot id: A0A452DXT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:MAP3K5
gene id: 9925:MAP3K5
uniprot id: A0A452FWU2
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9925:TUBGCP2
gene id: 9925:TUBGCP2
uniprot id: A0A452ELP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9925:AVL9
gene id: 9925:AVL9
uniprot id: A0A452EQ84
names: Subcellular Location Annotation
messages: Endosome
messages: Recycling endosome

9925:CDC37L1
gene id: 9925:CDC37L1
uniprot id: A0A452G209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9925:TARS
gene id: 9925:TARS
uniprot id: A0A452EHA4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9925:ZFP36L2
gene id: 9925:ZFP36L2
uniprot id: A0A452G1H7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9925:MARCO
gene id: 9925:MARCO
uniprot id: A0A452FYZ2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:DYNLL1
gene id: 9925:DYNLL1
uniprot id: A0A452F8J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9925:LOC102181521
gene id: 9925:LOC102181521
uniprot id: A0A452DRM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:APPL2
gene id: 9925:APPL2
uniprot id: A0A452E4C0
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9925:BNIP1
gene id: 9925:BNIP1
uniprot id: A0A452DVN7
names: Subcellular Location Annotation
messages: Membrane

9925:TRAPPC13
gene id: 9925:TRAPPC13
uniprot id: A0A452FV50
uniprot id: A0A452FVC2
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9925:LOC102187417
gene id: 9925:LOC102187417
uniprot id: A0A452DQL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PFKFB2
gene id: 9925:PFKFB2
uniprot id: A0A452FXL5
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9925:FUT7
gene id: 9925:FUT7
uniprot id: A0A452E2G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9925:LOC102177819
gene id: 9925:LOC102177819
uniprot id: A0A452E5Z9
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9925:ZSCAN16
gene id: 9925:ZSCAN16
uniprot id: A0A452EB82
names: Subcellular Location Annotation
messages: Nucleus

9925:ATP6V0D1
gene id: 9925:ATP6V0D1
uniprot id: A0A452F0M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9925:KCNJ12
gene id: 9925:KCNJ12
uniprot id: A0A452E375
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

9925:PDX1
gene id: 9925:PDX1
uniprot id: A0A452EUF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:PDGFC
gene id: 9925:PDGFC
uniprot id: A0A452ET29
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:STEAP2
gene id: 9925:STEAP2
uniprot id: A0A452FEV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9925:GABRD
gene id: 9925:GABRD
uniprot id: A0A452FI90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:TMEM150A
gene id: 9925:TMEM150A
uniprot id: A0A452FDR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Membrane

9925:PFDN5
gene id: 9925:PFDN5
uniprot id: A0A452FGQ5
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9925:TMEM192
gene id: 9925:TMEM192
uniprot id: A0A452G2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9925:PPFIBP1
gene id: 9925:PPFIBP1
uniprot id: A0A452G647
uniprot id: A0A452G678
uniprot id: A0A452G692
uniprot id: A0A452G698
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9925:CAPN7
gene id: 9925:CAPN7
uniprot id: A0A452FN84
names: Similarity
messages: Belongs to the peptidase C2 family.

9925:EFNB3
gene id: 9925:EFNB3
uniprot id: A0A452GB79
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:APAF1
gene id: 9925:APAF1
uniprot id: A0A0F6QJN8
uniprot id: A0A452G5Z1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

9925:PMS1
gene id: 9925:PMS1
uniprot id: A0A452EGA0
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9925:CTGF
gene id: 9925:CTGF
uniprot id: A0A452G077
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:OTUD7A
gene id: 9925:OTUD7A
uniprot id: A0A452EXL1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:GALNT11
gene id: 9925:GALNT11
uniprot id: A0A452G8Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:GDF6
gene id: 9925:GDF6
uniprot id: A0A452FA65
names: Similarity
messages: Belongs to the TGF-beta family.

9925:C11H2orf49
gene id: 9925:C11H2orf49
uniprot id: A0A452E9A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9925:POU1F1
gene id: 9925:POU1F1
uniprot id: D0PQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Nucleus

9925:LOC102180829
gene id: 9925:LOC102180829
uniprot id: A0A452ESP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:TMEM258
gene id: 9925:TMEM258
uniprot id: A0A8C2SB61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9925:PHC3
gene id: 9925:PHC3
uniprot id: A0A452EJB2
uniprot id: A0A452EJJ2
uniprot id: A0A452EJM2
names: Subcellular Location Annotation
messages: Nucleus

9925:LRRC42
gene id: 9925:LRRC42
uniprot id: A0A452FC61
names: Similarity
messages: Belongs to the LRRC42 family.

9925:OS9
gene id: 9925:OS9
uniprot id: A0A452G0B8
uniprot id: A0A8C2RH14
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9925:LSM7
gene id: 9925:LSM7
uniprot id: A0A8C2SJ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9925:MMP16
gene id: 9925:MMP16
uniprot id: A0A452EG34
names: Similarity
messages: Belongs to the peptidase M10A family.

9925:LEPROT
gene id: 9925:LEPROT
uniprot id: A0A8C2QTL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9925:KCNJ11
gene id: 9925:KCNJ11
uniprot id: A0A452E0N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9925:APC
gene id: 9925:APC
uniprot id: A0A452FYS5
uniprot id: A0A452FYX7
uniprot id: A0A452FZ37
uniprot id: A0A452FZK1
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9925:TUBB6
gene id: 9925:TUBB6
uniprot id: A0A452G1A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9925:ITGA4
gene id: 9925:ITGA4
uniprot id: A0A452F9E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:FMNL3
gene id: 9925:FMNL3
uniprot id: A0A452ERD3
uniprot id: A0A452ERF2
uniprot id: A0A452ESE6
uniprot id: A0A8C2NC18
names: Similarity
messages: Belongs to the formin homology family.

9925:LTBP3
gene id: 9925:LTBP3
uniprot id: A0A452FUD2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:NTF4
gene id: 9925:NTF4
uniprot id: A0A452DZW8
names: Similarity
messages: Belongs to the NGF-beta family.

9925:ACSS2
gene id: 9925:ACSS2
uniprot id: A0A452FVM9
uniprot id: A0A452FVS4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:COMP
gene id: 9925:COMP
uniprot id: A0A452EQ17
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:GGNBP2
gene id: 9925:GGNBP2
uniprot id: A0A452F422
uniprot id: A0A452F482
uniprot id: A0A8C2RQ66
uniprot id: A0A8C2RT53
names: Function
messages: May be involved in spermatogenesis.

9925:PLD3
gene id: 9925:PLD3
uniprot id: A0A452FWZ1
names: Similarity
messages: Belongs to the phospholipase D family.

9925:FAM129B
gene id: 9925:FAM129B
uniprot id: A0A452DWE7
names: Similarity
messages: Belongs to the Niban family.

9925:IL12B
gene id: 9925:IL12B
uniprot id: P68221
uniprot id: Q6E218
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Secreted

9925:HAS2
gene id: 9925:HAS2
uniprot id: A0A452E885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

9925:TRIM46
gene id: 9925:TRIM46
uniprot id: A0A452E1C4
names: Subcellular Location Annotation
messages: cytoskeleton

9925:WASL
gene id: 9925:WASL
uniprot id: A0A452EUT6
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102191477
gene id: 9925:LOC102191477
uniprot id: A0A452E2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CD5
gene id: 9925:CD5
uniprot id: A0A452DRH8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PUS7L
gene id: 9925:PUS7L
uniprot id: A0A452E7S8
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9925:TYRP1
gene id: 9925:TYRP1
uniprot id: Q9XSG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9925:CARTPT
gene id: 9925:CARTPT
uniprot id: A0A452E7P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9925:ENAH
gene id: 9925:ENAH
uniprot id: A0A452FND5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

9925:RPIA
gene id: 9925:RPIA
uniprot id: A0A452EW62
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9925:ADAM17
gene id: 9925:ADAM17
uniprot id: A0A452EHS2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:NACC2
gene id: 9925:NACC2
uniprot id: A0A452DVR0
names: Subcellular Location Annotation
messages: Nucleus

9925:WASF1
gene id: 9925:WASF1
uniprot id: A0A452EAW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9925:PDLIM1
gene id: 9925:PDLIM1
uniprot id: A0A452FHJ5
names: Subcellular Location Annotation
messages: Z line

9925:LOC102185760
gene id: 9925:LOC102185760
uniprot id: A0A452DQ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RNF31
gene id: 9925:RNF31
uniprot id: A0A452G9V5
names: Similarity
messages: Belongs to the RBR family.

9925:CPEB4
gene id: 9925:CPEB4
uniprot id: A0A452E6A7
uniprot id: A0A452E6C4
uniprot id: A0A452E6E4
names: Similarity
messages: Belongs to the RRM CPEB family.

9925:C1QBP
gene id: 9925:C1QBP
uniprot id: A0A452GBK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

9925:SMIM5
gene id: 9925:SMIM5
uniprot id: A0A452G5C3
names: Subcellular Location Annotation
messages: Membrane

9925:PLAC8L1
gene id: 9925:PLAC8L1
uniprot id: A0A452EAW4
names: Similarity
messages: Belongs to the cornifelin family.

9925:CBL
gene id: 9925:CBL
uniprot id: A0A452DW08
uniprot id: A0A452DW21
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9925:LOC108636632
gene id: 9925:LOC108636632
uniprot id: A0A452EBR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Monomer.
messages: Secreted

9925:FGGY
gene id: 9925:FGGY
uniprot id: A0A452FMW3
names: Similarity
messages: Belongs to the FGGY kinase family.

9925:LOC102170546
gene id: 9925:LOC102170546
uniprot id: A0A452DQM1
names: Similarity
messages: Belongs to the KRTAP type 3 family.

9925:ZNF622
gene id: 9925:ZNF622
uniprot id: A0A452DVH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9925:CALHM1
gene id: 9925:CALHM1
uniprot id: A0A452DLY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9925:CHST3
gene id: 9925:CHST3
uniprot id: A0A452FDR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9925:NSMCE1
gene id: 9925:NSMCE1
uniprot id: A0A452FBG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9925:EFTUD2
gene id: 9925:EFTUD2
uniprot id: A0A452E8S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Nucleus

9925:SERINC2
gene id: 9925:SERINC2
uniprot id: A0A452DVJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9925:MYADM
gene id: 9925:MYADM
uniprot id: A0A452DWG6
names: Subcellular Location Annotation
messages: Membrane

9925:GPR171
gene id: 9925:GPR171
uniprot id: A0A452DX34
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:FAM234B
gene id: 9925:FAM234B
uniprot id: A0A452ECA7
names: Similarity
messages: Belongs to the FAM234 family.

9925:GTF2H1
gene id: 9925:GTF2H1
uniprot id: A0A452EM76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9925:MIDN
gene id: 9925:MIDN
uniprot id: A0A452EXT3
uniprot id: A0A452EXV4
names: Subcellular Location Annotation
messages: Nucleus

9925:TSSC1
gene id: 9925:TSSC1
uniprot id: A0A452FEK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

9925:LOC102180151
gene id: 9925:LOC102180151
uniprot id: A0A452F893
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102169935
gene id: 9925:LOC102169935
uniprot id: A0A452EAS0
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9925:TUBD1
gene id: 9925:TUBD1
uniprot id: A0A452F1L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9925:SULT6B1
gene id: 9925:SULT6B1
uniprot id: A0A452FYG5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:XRCC5
gene id: 9925:XRCC5
uniprot id: A0A452FLL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus

9925:CSGALNACT1
gene id: 9925:CSGALNACT1
uniprot id: A0A452G045
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9925:EIF4ENIF1
gene id: 9925:EIF4ENIF1
uniprot id: A0A452EVX9
uniprot id: A0A452EVY9
names: Subcellular Location Annotation
messages: Cytoplasm

9925:ODF1
gene id: 9925:ODF1
uniprot id: I6ZM92
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9925:HAUS3
gene id: 9925:HAUS3
uniprot id: A0A452EJP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9925:LOC102188268
gene id: 9925:LOC102188268
uniprot id: A0A452EIE8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9925:HSD17B1
gene id: 9925:HSD17B1
uniprot id: A0A452FYT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Favors the reduction of estrogens and androgens. Uses preferentially NADH.

9925:ABCG1
gene id: 9925:ABCG1
uniprot id: A0A452DUB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9925:FAM83D
gene id: 9925:FAM83D
uniprot id: A0A452FTM2
names: Similarity
messages: Belongs to the FAM83 family.

9925:GJC3
gene id: 9925:GJC3
uniprot id: A0A452DRY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:FABP3
gene id: 9925:FABP3
uniprot id: Q6S4N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:EHF
gene id: 9925:EHF
uniprot id: A0A452E3W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:LOC102175048
gene id: 9925:LOC102175048
uniprot id: A0A452DN84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PFN3
gene id: 9925:PFN3
uniprot id: A0A452DUA0
names: Similarity
messages: Belongs to the profilin family.

9925:SDHA
gene id: 9925:SDHA
uniprot id: A0A452F2G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9925:TBX5
gene id: 9925:TBX5
uniprot id: A0A452FW88
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:TJP3
gene id: 9925:TJP3
uniprot id: A0A452F2J2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9925:OGN
gene id: 9925:OGN
uniprot id: A0A452EV37
uniprot id: A1YZ35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

9925:SNAPIN
gene id: 9925:SNAPIN
uniprot id: A0A452F662
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9925:EDEM1
gene id: 9925:EDEM1
uniprot id: A0A452E774
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9925:LOC102180153
gene id: 9925:LOC102180153
uniprot id: A0A452DN89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9925:ELP4
gene id: 9925:ELP4
uniprot id: A0A452E6F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

9925:CLCNKA
gene id: 9925:CLCNKA
uniprot id: A0A452G531
names: Subcellular Location Annotation
messages: Membrane

9925:PET117
gene id: 9925:PET117
uniprot id: A0A452DWM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

9925:BTD
gene id: 9925:BTD
uniprot id: A0A452EN48
uniprot id: A0A452EP82
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9925:MVB12A
gene id: 9925:MVB12A
uniprot id: A0A452EPH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9925:LOC102175300
gene id: 9925:LOC102175300
uniprot id: A0A8C2RQ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PPP1R12B
gene id: 9925:PPP1R12B
uniprot id: A0A452EFR2
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9925:HOXC13
gene id: 9925:HOXC13
uniprot id: A0A2S1UF42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:MMP14
gene id: 9925:MMP14
uniprot id: Q9XSP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Cytoplasm
messages: Melanosome

9925:LOC102189437
gene id: 9925:LOC102189437
uniprot id: A0A452E8K0
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:SLC27A5
gene id: 9925:SLC27A5
uniprot id: A0A452DN39
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:LOC102173863
gene id: 9925:LOC102173863
uniprot id: A0A452EZZ5
names: Subcellular Location Annotation
messages: Membrane

9925:MFSD6
gene id: 9925:MFSD6
uniprot id: A0A452ED57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9925:CBFA2T2
gene id: 9925:CBFA2T2
uniprot id: A0A452EZL3
names: Similarity
messages: Belongs to the CBFA2T family.

9925:TFCP2L1
gene id: 9925:TFCP2L1
uniprot id: A0A452EMG8
uniprot id: A0A452EMH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9925:NOP10
gene id: 9925:NOP10
uniprot id: A0A452EA49
names: Similarity
messages: Belongs to the NOP10 family.

9925:ILK
gene id: 9925:ILK
uniprot id: A0A452F0A3
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9925:CTU1
gene id: 9925:CTU1
uniprot id: A0A452FXN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9925:ZIC5
gene id: 9925:ZIC5
uniprot id: A0A452E2Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9925:BCAS2
gene id: 9925:BCAS2
uniprot id: A0A452FNL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

9925:PDGFB
gene id: 9925:PDGFB
uniprot id: A0A452G438
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9925:PAQR6
gene id: 9925:PAQR6
uniprot id: A0A452F9Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9925:SKA3
gene id: 9925:SKA3
uniprot id: A0A452F0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9925:CPB1
gene id: 9925:CPB1
uniprot id: A0A452DTC9
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:GORASP1
gene id: 9925:GORASP1
uniprot id: A0A452EGP0
names: Similarity
messages: Belongs to the GORASP family.

9925:RALY
gene id: 9925:RALY
uniprot id: A0A452G880
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9925:LOC102174036
gene id: 9925:LOC102174036
uniprot id: A0A452EH52
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:THOP1
gene id: 9925:THOP1
uniprot id: A0A452EIZ0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9925:ISCA1
gene id: 9925:ISCA1
uniprot id: A0A452ESP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9925:DECR2
gene id: 9925:DECR2
uniprot id: A0A452FSY2
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

9925:ACP1
gene id: 9925:ACP1
uniprot id: A0A8C2R7B0
uniprot id: G1DG29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9925:LOC108635646
gene id: 9925:LOC108635646
uniprot id: A0A452DPC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9925:ESRP2
gene id: 9925:ESRP2
uniprot id: A0A452FYS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus

9925:LOC102180464
gene id: 9925:LOC102180464
uniprot id: A0A452DQ62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CNR2
gene id: 9925:CNR2
uniprot id: A0A452DMC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:ZHX1
gene id: 9925:ZHX1
uniprot id: A0A452E8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9925:CHRNA3
gene id: 9925:CHRNA3
uniprot id: A0A452ELM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:EIF2A
gene id: 9925:EIF2A
uniprot id: A0A452FUT9
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9925:VWC2
gene id: 9925:VWC2
uniprot id: A0A452FG22
names: Subcellular Location Annotation
messages: Synapse

9925:TMEM38B
gene id: 9925:TMEM38B
uniprot id: A0A452EMU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9925:WNT1
gene id: 9925:WNT1
uniprot id: A0A452F7P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:MMP11
gene id: 9925:MMP11
uniprot id: A0A452FG56
names: Similarity
messages: Belongs to the peptidase M10A family.

9925:CLDN9
gene id: 9925:CLDN9
uniprot id: A0A452DN63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:PSMC3
gene id: 9925:PSMC3
uniprot id: A0A8C2RTT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9925:SYT14
gene id: 9925:SYT14
uniprot id: A0A8C2XY47
names: Similarity
messages: Belongs to the synaptotagmin family.

9925:RIPK2
gene id: 9925:RIPK2
uniprot id: A0A452F5Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.

9925:COPG1
gene id: 9925:COPG1
uniprot id: A0A452E6C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9925:UBE4A
gene id: 9925:UBE4A
uniprot id: A0A452F377
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9925:AIM1
gene id: 9925:AIM1
uniprot id: A0A452FFP3
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:C2H2orf76
gene id: 9925:C2H2orf76
uniprot id: A0A452EZS7
names: Similarity
messages: Belongs to the UPF0538 family.

9925:IL7
gene id: 9925:IL7
uniprot id: A0A452EFQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Interacts with IL7R and CSF2RG.
messages: Secreted

9925:TBX2
gene id: 9925:TBX2
uniprot id: A0A452ELH5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:CCL26
gene id: 9925:CCL26
uniprot id: A0A452FTU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:CORO1A
gene id: 9925:CORO1A
uniprot id: A0A452FJC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

9925:TMEM106C
gene id: 9925:TMEM106C
uniprot id: A0A452G313
names: Similarity
messages: Belongs to the TMEM106 family.

9925:CARMIL3
gene id: 9925:CARMIL3
uniprot id: A0A452DXZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9925:NOG
gene id: 9925:NOG
uniprot id: A0A2Z4FR29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9925:GDPD1
gene id: 9925:GDPD1
uniprot id: A0A452G3E3
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9925:BMPR1A
gene id: 9925:BMPR1A
uniprot id: A0A452DLL6
uniprot id: G3LUU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:NUDT21
gene id: 9925:NUDT21
uniprot id: A0A452G8A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

9925:LOC102179036
gene id: 9925:LOC102179036
uniprot id: A0A452FRZ3
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9925:ZNF24
gene id: 9925:ZNF24
uniprot id: A0A452DJX4
names: Subcellular Location Annotation
messages: Nucleus

9925:SENP5
gene id: 9925:SENP5
uniprot id: A0A452ECA1
uniprot id: A0A452ECH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9925:NKIRAS2
gene id: 9925:NKIRAS2
uniprot id: A0A452GB54
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9925:PARVB
gene id: 9925:PARVB
uniprot id: A0A452G0K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9925:THEMIS2
gene id: 9925:THEMIS2
uniprot id: A0A452EDD8
names: Similarity
messages: Belongs to the themis family.

9925:HAMP
gene id: 9925:HAMP
uniprot id: A0A452G6H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9925:PSMD9
gene id: 9925:PSMD9
uniprot id: A0A452FD51
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9925:MED27
gene id: 9925:MED27
uniprot id: A0A452FNR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:CENPB
gene id: 9925:CENPB
uniprot id: A0A452E632
names: Subcellular Location Annotation
messages: Nucleus

9925:RFTN2
gene id: 9925:RFTN2
uniprot id: A0A452EDW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9925:GAB1
gene id: 9925:GAB1
uniprot id: A0A452G048
names: Similarity
messages: Belongs to the GAB family.

9925:ELMO2
gene id: 9925:ELMO2
uniprot id: A0A452EBD5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9925:RFC5
gene id: 9925:RFC5
uniprot id: A0A452EXR1
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9925:FTL
gene id: 9925:FTL
uniprot id: A0A452G176
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9925:LOC102179469
gene id: 9925:LOC102179469
uniprot id: A0A452DW09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:SERPINI1
gene id: 9925:SERPINI1
uniprot id: A0A452DLZ5
names: Similarity
messages: Belongs to the serpin family.

9925:GMDS
gene id: 9925:GMDS
uniprot id: A0A452F187
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9925:LOC102189501
gene id: 9925:LOC102189501
uniprot id: A0A452EGY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GPR156
gene id: 9925:GPR156
uniprot id: A0A452FJ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9925:AKIRIN1
gene id: 9925:AKIRIN1
uniprot id: A0A452ETW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9925:MYO1A
gene id: 9925:MYO1A
uniprot id: A0A452E9U3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:ETFDH
gene id: 9925:ETFDH
uniprot id: A0A452FRH5
uniprot id: A0A8C2RYU3
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9925:LOC106503501
gene id: 9925:LOC106503501
uniprot id: A0A452DY82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:NDUFA13
gene id: 9925:NDUFA13
uniprot id: A0A452DRD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

9925:SLC35A5
gene id: 9925:SLC35A5
uniprot id: A0A452F9D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9925:ENO2
gene id: 9925:ENO2
uniprot id: G9JNA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9925:SPOPL
gene id: 9925:SPOPL
uniprot id: A0A452FFL5
uniprot id: A0A452FGC7
names: Similarity
messages: Belongs to the Tdpoz family.

9925:KCNG3
gene id: 9925:KCNG3
uniprot id: A0A452FS63
uniprot id: A0A8C2NJM1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:LOC102177846
gene id: 9925:LOC102177846
uniprot id: A0A452DNE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9925:LOC102177738
gene id: 9925:LOC102177738
uniprot id: A0A452DX48
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SCAMP5
gene id: 9925:SCAMP5
uniprot id: A0A452F6D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9925:CNGA4
gene id: 9925:CNGA4
uniprot id: A0A452G9Y4
names: Subcellular Location Annotation
messages: Membrane

9925:SPDL1
gene id: 9925:SPDL1
uniprot id: A0A452EQ60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9925:PDE4D
gene id: 9925:PDE4D
uniprot id: A0A452EZC8
uniprot id: A0A452EZJ8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:MYH9
gene id: 9925:MYH9
uniprot id: A0A452FAW1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:SMARCAD1
gene id: 9925:SMARCAD1
uniprot id: A0A452EEN5
names: Subcellular Location Annotation
messages: Chromosome

9925:ATP6V0D2
gene id: 9925:ATP6V0D2
uniprot id: A0A452FMV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9925:STAM2
gene id: 9925:STAM2
uniprot id: A0A452FF70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9925:SUCLA2
gene id: 9925:SUCLA2
uniprot id: A0A452F6E5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9925:GALNTL6
gene id: 9925:GALNTL6
uniprot id: A0A8C2QW02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:RXRG
gene id: 9925:RXRG
uniprot id: A0A452G8I4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9925:ANKRD13C
gene id: 9925:ANKRD13C
uniprot id: A0A452FIT2
names: Subcellular Location Annotation
messages: Membrane

9925:IL25
gene id: 9925:IL25
uniprot id: A0A8C2R843
names: Similarity
messages: Belongs to the IL-17 family.

9925:THPO
gene id: 9925:THPO
uniprot id: A0A452F1T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9925:MS4A1
gene id: 9925:MS4A1
uniprot id: A0A452ELI0
names: Similarity
messages: Belongs to the MS4A family.

9925:CKAP5
gene id: 9925:CKAP5
uniprot id: A0A452F4P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

9925:LOC106501717
gene id: 9925:LOC106501717
uniprot id: A0A452G617
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9925:F12
gene id: 9925:F12
uniprot id: A0A452DRJ1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:API5
gene id: 9925:API5
uniprot id: A0A452EQ87
names: Similarity
messages: Belongs to the API5 family.

9925:LOC102171353
gene id: 9925:LOC102171353
uniprot id: A0A452E8M9
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:HEXB
gene id: 9925:HEXB
uniprot id: A0A452FEW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9925:NDUFA7
gene id: 9925:NDUFA7
uniprot id: A0A8C2PBE4
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9925:HYAL3
gene id: 9925:HYAL3
uniprot id: A0A452EY13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Membrane
messages: acrosome

9925:ANKRD13A
gene id: 9925:ANKRD13A
uniprot id: A0A452FKY4
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9925:GPR137C
gene id: 9925:GPR137C
uniprot id: A0A452FAK8
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9925:NTRK1
gene id: 9925:NTRK1
uniprot id: A0A452FSK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9925:IL1RL1
gene id: 9925:IL1RL1
uniprot id: A0A452EZZ4
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9925:LOC102175871
gene id: 9925:LOC102175871
uniprot id: A0A452FCH3
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9925:KCNMB1
gene id: 9925:KCNMB1
uniprot id: A0A452EUN6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9925:CNNM2
gene id: 9925:CNNM2
uniprot id: A0A452EVU5
uniprot id: A0A452EVV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9925:LOC100861279
gene id: 9925:LOC100861279
uniprot id: A1E458
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:SEPHS1
gene id: 9925:SEPHS1
uniprot id: A0A452GAE9
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9925:LPCAT3
gene id: 9925:LPCAT3
uniprot id: A0A452EN28
names: Subcellular Location Annotation
messages: Membrane

9925:GJA3
gene id: 9925:GJA3
uniprot id: A0A452DNZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:SETD7
gene id: 9925:SETD7
uniprot id: A0A452E0J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Nucleus

9925:PIK3R3
gene id: 9925:PIK3R3
uniprot id: A0A452ET07
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9925:ERCC2
gene id: 9925:ERCC2
uniprot id: A0A452FRN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

9925:ARHGAP32
gene id: 9925:ARHGAP32
uniprot id: A0A452F4I2
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

9925:TPH2
gene id: 9925:TPH2
uniprot id: A0A452DPA3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9925:SCP2
gene id: 9925:SCP2
uniprot id: A0A452DRP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion
messages: Peroxisome

9925:ACTRT3
gene id: 9925:ACTRT3
uniprot id: A0A452EFY7
names: Similarity
messages: Belongs to the actin family.

9925:STX19
gene id: 9925:STX19
uniprot id: A0A452DNT7
names: Similarity
messages: Belongs to the syntaxin family.

9925:DDAH2
gene id: 9925:DDAH2
uniprot id: A0A452G8U8
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9925:CASC1
gene id: 9925:CASC1
uniprot id: A0A452EUR8
names: Similarity
messages: Belongs to the DNAI7 family.

9925:CD164L2
gene id: 9925:CD164L2
uniprot id: A0A452FVU6
uniprot id: A0A8C2QSE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9925:RAB39A
gene id: 9925:RAB39A
uniprot id: A0A452FBJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9925:MTX1
gene id: 9925:MTX1
uniprot id: A0A8C2N5D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:SFXN2
gene id: 9925:SFXN2
uniprot id: A0A8C2XUH8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9925:LOC108633450
gene id: 9925:LOC108633450
uniprot id: A0A452DZD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ANGPTL4
gene id: 9925:ANGPTL4
uniprot id: A0A452FU98
names: Subcellular Location Annotation
messages: Secreted

9925:SLC12A3
gene id: 9925:SLC12A3
uniprot id: A0A452FPI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9925:LOC102188468
gene id: 9925:LOC102188468
uniprot id: A0A452EB50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MTFR2
gene id: 9925:MTFR2
uniprot id: A0A452E4I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9925:DGKB
gene id: 9925:DGKB
uniprot id: A0A452FGG3
uniprot id: A0A452FGK8
uniprot id: A0A452FH45
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9925:TAF1D
gene id: 9925:TAF1D
uniprot id: A0A452G7H4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9925:LOC102169174
gene id: 9925:LOC102169174
uniprot id: A0A452E8W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102181002
gene id: 9925:LOC102181002
uniprot id: A0A452ELP7
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:LOC102188114
gene id: 9925:LOC102188114
uniprot id: A0A452EEQ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:GMPR
gene id: 9925:GMPR
uniprot id: A0A8C2Y192
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9925:ITGB2
gene id: 9925:ITGB2
uniprot id: Q5VI41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Heterodimer of an alpha and a beta subunit. The ITGB2 beta subunit associates with the ITGAL, ITGAM, ITGAX or ITGAD alpah subunits. Found in a complex with CD177 and ITGAM/CD11b. Interacts with FGR. Interacts with COPS5 and RANBP9. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23). Interacts with THBD.
messages: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.
messages: Membrane raft

9925:TOMM40L
gene id: 9925:TOMM40L
uniprot id: A0A452F2K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:EPN2
gene id: 9925:EPN2
uniprot id: A0A452G7G3
names: Similarity
messages: Belongs to the epsin family.

9925:LHX2
gene id: 9925:LHX2
uniprot id: A0A077ESX4
names: Subcellular Location Annotation
messages: Nucleus

9925:SLC25A16
gene id: 9925:SLC25A16
uniprot id: A0A452EIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:LOC102182048
gene id: 9925:LOC102182048
uniprot id: A0A452G7V8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9925:TRAF3
gene id: 9925:TRAF3
uniprot id: A0A452G7I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9925:DCP1A
gene id: 9925:DCP1A
uniprot id: A0A8C2SJE2
names: Similarity
messages: Belongs to the DCP1 family.

9925:LOC102174258
gene id: 9925:LOC102174258
uniprot id: A0A452EBE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102176567
gene id: 9925:LOC102176567
uniprot id: A0A452FQY0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:FAM149A
gene id: 9925:FAM149A
uniprot id: A0A452ETY2
names: Similarity
messages: Belongs to the FAM149 family.

9925:LOC102183140
gene id: 9925:LOC102183140
uniprot id: A0A452DNC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9925:LOC102189985
gene id: 9925:LOC102189985
uniprot id: A0A452EHR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:ASIC3
gene id: 9925:ASIC3
uniprot id: A0A452ERK5
names: Subcellular Location Annotation
messages: Membrane

9925:SLC17A8
gene id: 9925:SLC17A8
uniprot id: A0A452EXX9
names: Subcellular Location Annotation
messages: Membrane

9925:UGDH
gene id: 9925:UGDH
uniprot id: A0A452G134
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9925:MMP27
gene id: 9925:MMP27
uniprot id: A0A452ED54
names: Similarity
messages: Belongs to the peptidase M10A family.

9925:TMEM242
gene id: 9925:TMEM242
uniprot id: A0A452E1X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9925:PPP1R15B
gene id: 9925:PPP1R15B
uniprot id: A0A452EEV5
names: Similarity
messages: Belongs to the PPP1R15 family.

9925:ASCC3
gene id: 9925:ASCC3
uniprot id: A0A452FU25
names: Similarity
messages: Belongs to the helicase family.

9925:LOC102184922
gene id: 9925:LOC102184922
uniprot id: A0A452DMQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9925:LOC102180194
gene id: 9925:LOC102180194
uniprot id: A0A452EGE3
names: Subcellular Location Annotation
messages: Secreted

9925:TMEM161B
gene id: 9925:TMEM161B
uniprot id: A0A452G872
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9925:LOC102168295
gene id: 9925:LOC102168295
uniprot id: A0A452DSW4
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9925:LOC102174738
gene id: 9925:LOC102174738
uniprot id: A0A452EQQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

9925:LOC108637886
gene id: 9925:LOC108637886
uniprot id: A0A452DW17
names: Similarity
messages: Belongs to the PPP phosphatase family.

9925:LOC102189358
gene id: 9925:LOC102189358
uniprot id: A0A452DX52
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:HOXD3
gene id: 9925:HOXD3
uniprot id: A0A452E941
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:DCTD
gene id: 9925:DCTD
uniprot id: G1DG43
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9925:LRP5
gene id: 9925:LRP5
uniprot id: A0A452FA21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:LOC102173983
gene id: 9925:LOC102173983
uniprot id: A0A452E0V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:AP4S1
gene id: 9925:AP4S1
uniprot id: A0A452ETL1
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9925:FAM228A
gene id: 9925:FAM228A
uniprot id: A0A8C2SBQ2
names: Similarity
messages: Belongs to the FAM228 family.

9925:ATP2B1
gene id: 9925:ATP2B1
uniprot id: A0A452FY34
uniprot id: A0A452FYI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: synaptic vesicle membrane

9925:ATE1
gene id: 9925:ATE1
uniprot id: A0A452E9Z1
uniprot id: A0A452EAJ6
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9925:NRCAM
gene id: 9925:NRCAM
uniprot id: A0A452G9B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9925:PPRC1
gene id: 9925:PPRC1
uniprot id: A0A452E8L4
names: Subcellular Location Annotation
messages: Nucleus

9925:ORAI1
gene id: 9925:ORAI1
uniprot id: A0A452F8V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9925:FAM219A
gene id: 9925:FAM219A
uniprot id: A0A8C2NX32
names: Similarity
messages: Belongs to the FAM219 family.

9925:MDK
gene id: 9925:MDK
uniprot id: A0A452FGX2
names: Similarity
messages: Belongs to the pleiotrophin family.

9925:FZD9
gene id: 9925:FZD9
uniprot id: A0A452DMA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9925:XKR9
gene id: 9925:XKR9
uniprot id: A0A452ES82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9925:SLC35C1
gene id: 9925:SLC35C1
uniprot id: A0A452FHB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

9925:VPS35
gene id: 9925:VPS35
uniprot id: A0A452G510
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9925:ITIH4
gene id: 9925:ITIH4
uniprot id: A0A452EHJ9
uniprot id: A0A452EHT7
uniprot id: A0A452EI28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9925:TFF2
gene id: 9925:TFF2
uniprot id: A0A452G5Z9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102177672
gene id: 9925:LOC102177672
uniprot id: A0A452G1F9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:FAM20A
gene id: 9925:FAM20A
uniprot id: A0A452G9R5
names: Similarity
messages: Belongs to the FAM20 family.

9925:FOXR1
gene id: 9925:FOXR1
uniprot id: A0A452F8Q4
names: Subcellular Location Annotation
messages: Nucleus

9925:SPR
gene id: 9925:SPR
uniprot id: A0A452FWA7
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9925:LOC102173864
gene id: 9925:LOC102173864
uniprot id: A0A452E4G0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GPN2
gene id: 9925:GPN2
uniprot id: A0A452EH26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9925:ABHD1
gene id: 9925:ABHD1
uniprot id: A0A452G9L4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9925:DUS3L
gene id: 9925:DUS3L
uniprot id: A0A452FHK9
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

9925:RPS17
gene id: 9925:RPS17
uniprot id: A0A452FU62
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9925:ENDOG
gene id: 9925:ENDOG
uniprot id: A0A452FG10
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9925:ADD3
gene id: 9925:ADD3
uniprot id: A0A452FCB9
uniprot id: A0A452FCG5
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9925:NT5E
gene id: 9925:NT5E
uniprot id: A0A452E4U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9925:GFM2
gene id: 9925:GFM2
uniprot id: A0A452EEF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9925:MBLAC1
gene id: 9925:MBLAC1
uniprot id: A0A8C2S6F2
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9925:CTNNB1
gene id: 9925:CTNNB1
uniprot id: A0A2Z4FR65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9925:LOC102171083
gene id: 9925:LOC102171083
uniprot id: A0A452E8K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TNFRSF9
gene id: 9925:TNFRSF9
uniprot id: A0A452E393
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:BAMBI
gene id: 9925:BAMBI
uniprot id: A0A452EPW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9925:DCSTAMP
gene id: 9925:DCSTAMP
uniprot id: A0A452FH22
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102172676
gene id: 9925:LOC102172676
uniprot id: A0A452EHW1
names: Similarity
messages: Belongs to the histone H2B family.

9925:ING3
gene id: 9925:ING3
uniprot id: A0A452E0X8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9925:DXO
gene id: 9925:DXO
uniprot id: A0A452FYH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9925:TNFRSF21
gene id: 9925:TNFRSF21
uniprot id: A0A452G6Q1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:NME9
gene id: 9925:NME9
uniprot id: A0A452EKJ7
names: Similarity
messages: Belongs to the NDK family.

9925:POLR2K
gene id: 9925:POLR2K
uniprot id: A0A452EEG0
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9925:BTG1
gene id: 9925:BTG1
uniprot id: H6WJI4
names: Function
names: Similarity
messages: Anti-proliferative protein.
messages: Belongs to the BTG family.

9925:RPRM
gene id: 9925:RPRM
uniprot id: A0A452DRH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Cytoplasm
messages: Membrane

9925:EIF3L
gene id: 9925:EIF3L
uniprot id: A0A452EL27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9925:FAM124B
gene id: 9925:FAM124B
uniprot id: A0A452DSR2
names: Similarity
messages: Belongs to the FAM124 family.

9925:GORASP2
gene id: 9925:GORASP2
uniprot id: A0A452EKD0
names: Similarity
messages: Belongs to the GORASP family.

9925:FGF3
gene id: 9925:FGF3
uniprot id: A0A452DMM2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:GRHPR
gene id: 9925:GRHPR
uniprot id: A0A452FAD3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9925:FAM8A1
gene id: 9925:FAM8A1
uniprot id: A0A452E2H0
names: Subcellular Location Annotation
messages: Membrane

9925:NSRP1
gene id: 9925:NSRP1
uniprot id: A0A452FI41
names: Similarity
messages: Belongs to the NSRP1 family.

9925:SMARCB1
gene id: 9925:SMARCB1
uniprot id: A0A452FB10
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

9925:AIDA
gene id: 9925:AIDA
uniprot id: A0A452DU64
names: Similarity
messages: Belongs to the AIDA family.

9925:LOC102191297
gene id: 9925:LOC102191297
uniprot id: A0A452DYN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:RAB14
gene id: 9925:RAB14
uniprot id: A0A452GAB9
uniprot id: A9LM13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9925:XYLT2
gene id: 9925:XYLT2
uniprot id: A0A452F578
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

9925:EBPL
gene id: 9925:EBPL
uniprot id: A0A452ELF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:CRTC3
gene id: 9925:CRTC3
uniprot id: A0A452F5X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9925:TMOD4
gene id: 9925:TMOD4
uniprot id: A0A452FRW8
names: Subcellular Location Annotation
messages: cytoskeleton

9925:DAG1
gene id: 9925:DAG1
uniprot id: A0A452ESY5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9925:GDF9
gene id: 9925:GDF9
uniprot id: B7U4A2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9925:NHEJ1
gene id: 9925:NHEJ1
uniprot id: A0A452ENS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

9925:GNG8
gene id: 9925:GNG8
uniprot id: A0A452F3S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:TLE6
gene id: 9925:TLE6
uniprot id: A0A452F5W9
names: Similarity
messages: Belongs to the WD repeat Groucho/TLE family.

9925:SH3RF2
gene id: 9925:SH3RF2
uniprot id: A0A452ELR8
names: Similarity
messages: Belongs to the SH3RF family.

9925:SDHC
gene id: 9925:SDHC
uniprot id: A0A8C2N9R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9925:NCOA2
gene id: 9925:NCOA2
uniprot id: A0A452E5Q1
uniprot id: A0A452E662
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9925:DGAT2
gene id: 9925:DGAT2
uniprot id: A0A452E3L6
uniprot id: M9MR46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:THAP1
gene id: 9925:THAP1
uniprot id: A0A452EC21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9925:MC4R
gene id: 9925:MC4R
uniprot id: G1EIN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9925:AHSA1
gene id: 9925:AHSA1
uniprot id: A0A452G5Y6
names: Similarity
messages: Belongs to the AHA1 family.

9925:SLC41A1
gene id: 9925:SLC41A1
uniprot id: A0A452ELH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9925:LOC106503979
gene id: 9925:LOC106503979
uniprot id: A0A452EEC5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9925:HOOK2
gene id: 9925:HOOK2
uniprot id: A0A452F265
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9925:LPIN2
gene id: 9925:LPIN2
uniprot id: A0A452E2L8
names: Similarity
messages: Belongs to the lipin family.

9925:CLUH
gene id: 9925:CLUH
uniprot id: A0A452DQ90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

9925:GK5
gene id: 9925:GK5
uniprot id: A0A452F2H8
names: Similarity
messages: Belongs to the FGGY kinase family.

9925:TRPV3
gene id: 9925:TRPV3
uniprot id: A0A452FFD9
names: Subcellular Location Annotation
messages: Membrane

9925:PTPN2
gene id: 9925:PTPN2
uniprot id: A0A452EI40
uniprot id: A0A452EI47
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9925:POPDC2
gene id: 9925:POPDC2
uniprot id: A0A452ENH5
names: Similarity
messages: Belongs to the popeye family.

9925:GATAD1
gene id: 9925:GATAD1
uniprot id: A0A452DSY5
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102180556
gene id: 9925:LOC102180556
uniprot id: A0A452ET78
names: Similarity
messages: Belongs to the serpin family.

9925:LOC102181206
gene id: 9925:LOC102181206
uniprot id: A0A452E0Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:POP7
gene id: 9925:POP7
uniprot id: A0A452EGR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9925:LHB
gene id: 9925:LHB
uniprot id: Q1RP71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9925:TUT1
gene id: 9925:TUT1
uniprot id: A0A452DTG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Nucleus speckle
messages: nucleolus

9925:TNFRSF4
gene id: 9925:TNFRSF4
uniprot id: A0A452FBG5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:UBA5
gene id: 9925:UBA5
uniprot id: A0A452FIL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9925:LOC102178292
gene id: 9925:LOC102178292
uniprot id: A0A452F4I4
names: Similarity
messages: Belongs to the MS4A family.

9925:LOC102175317
gene id: 9925:LOC102175317
uniprot id: A0A452F723
names: Similarity
messages: Belongs to the globin family.

9925:CDK5
gene id: 9925:CDK5
uniprot id: A0A452G5B1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:HPDL
gene id: 9925:HPDL
uniprot id: A0A452E319
names: Similarity
messages: Belongs to the 4HPPD family.

9925:EML1
gene id: 9925:EML1
uniprot id: A0A452EXS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9925:MINOS1
gene id: 9925:MINOS1
uniprot id: A0A452FTE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9925:ERAL1
gene id: 9925:ERAL1
uniprot id: A0A452FKY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

9925:LOC102178883
gene id: 9925:LOC102178883
uniprot id: A0A452E6Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DEDD2
gene id: 9925:DEDD2
uniprot id: A0A452FFA9
names: Subcellular Location Annotation
messages: nucleolus

9925:KIAA0391
gene id: 9925:KIAA0391
uniprot id: A0A452G6K1
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9925:LOC102180880
gene id: 9925:LOC102180880
uniprot id: A0A452G7P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:ATP6V1G3
gene id: 9925:ATP6V1G3
uniprot id: A0A452E362
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9925:RPRD1A
gene id: 9925:RPRD1A
uniprot id: A0A452F794
uniprot id: A0A452F842
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9925:TOM1L1
gene id: 9925:TOM1L1
uniprot id: A0A452EMQ1
names: Similarity
messages: Belongs to the TOM1 family.

9925:DDR2
gene id: 9925:DDR2
uniprot id: A0A452FL91
names: Subcellular Location Annotation
messages: Membrane

9925:CDC42EP3
gene id: 9925:CDC42EP3
uniprot id: A0A452DQJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9925:OPTN
gene id: 9925:OPTN
uniprot id: A0A452F2F0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Endosome
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9925:PSMB8
gene id: 9925:PSMB8
uniprot id: A0A452EE94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9925:TRAM2
gene id: 9925:TRAM2
uniprot id: A0A452EMI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9925:CDR2
gene id: 9925:CDR2
uniprot id: A0A452EG09
names: Similarity
messages: Belongs to the CDR2 family.

9925:WBSCR22
gene id: 9925:WBSCR22
uniprot id: A0A452FD58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9925:CHAC2
gene id: 9925:CHAC2
uniprot id: A0A452EWJ0
uniprot id: A0A452EWP6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9925:VGLL4
gene id: 9925:VGLL4
uniprot id: A0A452FBP5
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9925:SPTSSB
gene id: 9925:SPTSSB
uniprot id: A0A452DYT3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:NDUFV1
gene id: 9925:NDUFV1
uniprot id: A0A452FQM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9925:PRKACB
gene id: 9925:PRKACB
uniprot id: A0A452FXJ7
uniprot id: A0A452FXT1
uniprot id: A0A452FYA4
uniprot id: A0A452FYK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Nucleus

9925:FUBP1
gene id: 9925:FUBP1
uniprot id: A0A452EGT8
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102179868
gene id: 9925:LOC102179868
uniprot id: A0A452E2T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ZFYVE27
gene id: 9925:ZFYVE27
uniprot id: A0A8C2QY81
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9925:SDC2
gene id: 9925:SDC2
uniprot id: A0A452EQZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9925:ZNF274
gene id: 9925:ZNF274
uniprot id: A0A452EX19
names: Subcellular Location Annotation
messages: Nucleus

9925:VSX1
gene id: 9925:VSX1
uniprot id: A0A452FQL4
names: Subcellular Location Annotation
messages: Nucleus

9925:PAX7
gene id: 9925:PAX7
uniprot id: A0A452FU61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9925:SDC3
gene id: 9925:SDC3
uniprot id: A0A452ERE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9925:FUT11
gene id: 9925:FUT11
uniprot id: A0A452DKI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9925:LOC102183297
gene id: 9925:LOC102183297
uniprot id: A0A452FY31
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:MRPL37
gene id: 9925:MRPL37
uniprot id: A0A452EYL5
names: Subcellular Location Annotation
messages: Mitochondrion

9925:PSEN1
gene id: 9925:PSEN1
uniprot id: A0A452G1U1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9925:NFX1
gene id: 9925:NFX1
uniprot id: A0A452FCD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9925:LOC102184170
gene id: 9925:LOC102184170
uniprot id: A0A452E993
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CLIC4
gene id: 9925:CLIC4
uniprot id: A0A452E998
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9925:XRCC6
gene id: 9925:XRCC6
uniprot id: A0A452EDQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

9925:STRIP1
gene id: 9925:STRIP1
uniprot id: A0A452EBP8
names: Similarity
messages: Belongs to the STRIP family.

9925:TMPRSS15
gene id: 9925:TMPRSS15
uniprot id: A0A452EEU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMBT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:ITGAV
gene id: 9925:ITGAV
uniprot id: J7H550
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:GABRB2
gene id: 9925:GABRB2
uniprot id: A0A452G0D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:UROD
gene id: 9925:UROD
uniprot id: A0A452G9G3
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

9925:COPA
gene id: 9925:COPA
uniprot id: A0A452EPZ3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9925:GFM1
gene id: 9925:GFM1
uniprot id: A0A452EPF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9925:CAP1
gene id: 9925:CAP1
uniprot id: A0A452FHV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers.
messages: Membrane

9925:CD93
gene id: 9925:CD93
uniprot id: A0A452DZ60
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PYCR2
gene id: 9925:PYCR2
uniprot id: A0A452FLM2
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9925:NUBP1
gene id: 9925:NUBP1
uniprot id: A0A452DNB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9925:ELOVL7
gene id: 9925:ELOVL7
uniprot id: A0A452DNN6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9925:DLX2
gene id: 9925:DLX2
uniprot id: A0A452FZW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9925:STX12
gene id: 9925:STX12
uniprot id: A0A452FXY3
names: Similarity
messages: Belongs to the syntaxin family.

9925:DENND6A
gene id: 9925:DENND6A
uniprot id: A0A452E2G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

9925:LOC102178603
gene id: 9925:LOC102178603
uniprot id: A0A452DSE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:P2RX3
gene id: 9925:P2RX3
uniprot id: A0A452G0L6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9925:GBGT1
gene id: 9925:GBGT1
uniprot id: A0A452E7F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9925:CTSD
gene id: 9925:CTSD
uniprot id: A0A452DRN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

9925:ALB
gene id: 9925:ALB
uniprot id: A0A452F7K4
names: Subcellular Location Annotation
messages: Secreted

9925:RBBP5
gene id: 9925:RBBP5
uniprot id: A0A452EKQ1
names: Subcellular Location Annotation
messages: Nucleus

9925:ORC1
gene id: 9925:ORC1
uniprot id: A0A452EET2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus

9925:INSL5
gene id: 9925:INSL5
uniprot id: A0A452EUT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9925:LOC108633170
gene id: 9925:LOC108633170
uniprot id: A0A452DQ46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9925:KLC2
gene id: 9925:KLC2
uniprot id: A0A452ER77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9925:TIMM10
gene id: 9925:TIMM10
uniprot id: A0A452G6K6
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

9925:IST1
gene id: 9925:IST1
uniprot id: A0A452DRI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9925:NOS2
gene id: 9925:NOS2
uniprot id: A0A452FQT1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

9925:SPATA6
gene id: 9925:SPATA6
uniprot id: A0A452FMD8
names: Similarity
messages: Belongs to the SPATA6 family.

9925:CPSF6
gene id: 9925:CPSF6
uniprot id: A0A452E5B8
uniprot id: A0A452E5C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Cytoplasm
messages: Nucleus speckle
messages: nucleoplasm

9925:PPBP
gene id: 9925:PPBP
uniprot id: A0A452FUC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9925:RASSF1
gene id: 9925:RASSF1
uniprot id: A0A452FEJ9
names: Subcellular Location Annotation
messages: cytoskeleton

9925:GPC1
gene id: 9925:GPC1
uniprot id: A0A452G224
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: extracellular space

9925:BIVM
gene id: 9925:BIVM
uniprot id: A0A452FGW4
names: Similarity
messages: Belongs to the BIVM family.

9925:PPM1G
gene id: 9925:PPM1G
uniprot id: A0A452DQH5
names: Similarity
messages: Belongs to the PP2C family.

9925:UHRF1
gene id: 9925:UHRF1
uniprot id: A0A452F5K6
names: Subcellular Location Annotation
messages: Nucleus

9925:KCNAB2
gene id: 9925:KCNAB2
uniprot id: A0A452FNV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: synaptosome

9925:DDOST
gene id: 9925:DDOST
uniprot id: A0A8C2QYS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

9925:GALNT6
gene id: 9925:GALNT6
uniprot id: A0A452EZ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:ARGLU1
gene id: 9925:ARGLU1
uniprot id: A0A8C2NZY6
names: Similarity
messages: Belongs to the UPF0430 family.

9925:B4GALNT1
gene id: 9925:B4GALNT1
uniprot id: A0A452G8Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:SYCE1
gene id: 9925:SYCE1
uniprot id: A0A8C2R3K4
names: Similarity
messages: Belongs to the SYCE family.

9925:EGR3
gene id: 9925:EGR3
uniprot id: A0A452FPV1
uniprot id: A0A452FPX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9925:RNPEPL1
gene id: 9925:RNPEPL1
uniprot id: A0A452DVF8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9925:EPHA5
gene id: 9925:EPHA5
uniprot id: A0A452E3I8
uniprot id: A0A452E3J6
uniprot id: A0A452E3M1
names: Subcellular Location Annotation
messages: Membrane

9925:TWF1
gene id: 9925:TWF1
uniprot id: A0A452FSY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9925:MMP3
gene id: 9925:MMP3
uniprot id: A0A452FPV6
names: Similarity
messages: Belongs to the peptidase M10A family.

9925:EVA1B
gene id: 9925:EVA1B
uniprot id: A0A452E822
names: Similarity
messages: Belongs to the EVA1 family.

9925:MYO1G
gene id: 9925:MYO1G
uniprot id: A0A452FSI3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:PDYN
gene id: 9925:PDYN
uniprot id: A0A452EUL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
messages: Secreted

9925:MED18
gene id: 9925:MED18
uniprot id: A0A452FCN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:TYR
gene id: 9925:TYR
uniprot id: G9JKW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9925:DNAJC22
gene id: 9925:DNAJC22
uniprot id: A0A452FJY1
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9925:CELF3
gene id: 9925:CELF3
uniprot id: A0A452G4Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9925:SAR1A
gene id: 9925:SAR1A
uniprot id: A0A452F730
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9925:LOC102186833
gene id: 9925:LOC102186833
uniprot id: A0A452E2Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:VWA9
gene id: 9925:VWA9
uniprot id: A0A452EEK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9925:ACKR3
gene id: 9925:ACKR3
uniprot id: A0A452DNS6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:SEMA4C
gene id: 9925:SEMA4C
uniprot id: A0A452F0G1
uniprot id: A0A8C2P0U8
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:RABEP2
gene id: 9925:RABEP2
uniprot id: A0A452FRQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Early endosome
messages: Endosome
messages: centrosome
messages: cilium basal body

9925:LYNX1
gene id: 9925:LYNX1
uniprot id: A0A452EJA0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:CTSZ
gene id: 9925:CTSZ
uniprot id: A0A452E825
names: Similarity
messages: Belongs to the peptidase C1 family.

9925:KCNA10
gene id: 9925:KCNA10
uniprot id: A0A452E3W6
names: Subcellular Location Annotation
messages: Membrane

9925:ARRDC3
gene id: 9925:ARRDC3
uniprot id: A0A452G7C3
names: Similarity
messages: Belongs to the arrestin family.

9925:CLDN19
gene id: 9925:CLDN19
uniprot id: A0A452F236
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:LOC102175560
gene id: 9925:LOC102175560
uniprot id: A0A452EU19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9925:MFSD1
gene id: 9925:MFSD1
uniprot id: A0A452G180
names: Subcellular Location Annotation
messages: Membrane

9925:TNFSF14
gene id: 9925:TNFSF14
uniprot id: I3NP96
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9925:TOR1A
gene id: 9925:TOR1A
uniprot id: A0A452FDT1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum lumen
messages: Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane.
messages: Membrane
messages: growth cone

9925:LOC102189173
gene id: 9925:LOC102189173
uniprot id: A0A452DTG8
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:BCAT1
gene id: 9925:BCAT1
uniprot id: A0A452G0T4
uniprot id: A0A452G1Z3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9925:ARRDC1
gene id: 9925:ARRDC1
uniprot id: A0A452G3H1
names: Similarity
messages: Belongs to the arrestin family.

9925:RPS24
gene id: 9925:RPS24
uniprot id: A0A452DKU0
uniprot id: A0A452DLF2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9925:CAMK4
gene id: 9925:CAMK4
uniprot id: A0A452EA99
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:SDCCAG3
gene id: 9925:SDCCAG3
uniprot id: A0A452F6P7
uniprot id: A0A452F7B2
names: Similarity
messages: Belongs to the ENTR1 family.

9925:FAM3D
gene id: 9925:FAM3D
uniprot id: A0A452E271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9925:LOC102180845
gene id: 9925:LOC102180845
uniprot id: A0A452E1V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LHX8
gene id: 9925:LHX8
uniprot id: A0A452FF03
uniprot id: A0A452FF52
uniprot id: A0A452FFN3
names: Subcellular Location Annotation
messages: Nucleus

9925:AP3M1
gene id: 9925:AP3M1
uniprot id: A0A452DKD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9925:UCHL3
gene id: 9925:UCHL3
uniprot id: A0A452F429
uniprot id: A0A8C2QTW9
names: Similarity
messages: Belongs to the peptidase C12 family.

9925:NOL8
gene id: 9925:NOL8
uniprot id: A0A452FV23
names: Subcellular Location Annotation
messages: nucleolus

9925:TMEM59
gene id: 9925:TMEM59
uniprot id: A0A452E410
uniprot id: A0A452E420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:EEF1A1
gene id: 9925:EEF1A1
uniprot id: A0A452E2H7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9925:RAMP2
gene id: 9925:RAMP2
uniprot id: A0A452E0G3
names: Similarity
messages: Belongs to the RAMP family.

9925:NDRG3
gene id: 9925:NDRG3
uniprot id: A0A452F6D4
uniprot id: A0A8C2SI67
uniprot id: A0A8C2Y3L5
names: Similarity
messages: Belongs to the NDRG family.

9925:TRAPPC1
gene id: 9925:TRAPPC1
uniprot id: A0A452EHV5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9925:FADS2
gene id: 9925:FADS2
uniprot id: A0A452EQV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9925:NEDD9
gene id: 9925:NEDD9
uniprot id: A0A452FHJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9925:KCNA6
gene id: 9925:KCNA6
uniprot id: A0A452DWQ4
names: Subcellular Location Annotation
messages: Membrane

9925:PKP2
gene id: 9925:PKP2
uniprot id: A0A452ELU2
names: Similarity
messages: Belongs to the beta-catenin family.

9925:PNP
gene id: 9925:PNP
uniprot id: A0A452EAB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9925:FIS1
gene id: 9925:FIS1
uniprot id: A0A452FNI4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

9925:FNBP1L
gene id: 9925:FNBP1L
uniprot id: A0A452EN57
uniprot id: A0A452ENK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9925:CCK
gene id: 9925:CCK
uniprot id: A0A452F2Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9925:FAM65B
gene id: 9925:FAM65B
uniprot id: A0A452DUK8
uniprot id: A0A452DUN9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: stereocilium membrane

9925:IQSEC1
gene id: 9925:IQSEC1
uniprot id: A0A452G0T9
uniprot id: A0A452G0X9
names: Similarity
messages: Belongs to the BRAG family.

9925:HMMR
gene id: 9925:HMMR
uniprot id: A0A452G8Q7
names: Subcellular Location Annotation
messages: spindle

9925:SPRN
gene id: 9925:SPRN
uniprot id: C6ESG8
names: Function
names: Similarity
messages: Belongs to the SPRN family.
messages: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.

9925:AGP
gene id: 9925:AGP
uniprot id: A7Y9J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Functions as transport protein in the blood stream.
messages: Secreted

9925:RPS3
gene id: 9925:RPS3
uniprot id: A0A452EBJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: nucleolus
messages: spindle

9925:FOXI2
gene id: 9925:FOXI2
uniprot id: A0A452E2S3
names: Subcellular Location Annotation
messages: Nucleus

9925:CNOT2
gene id: 9925:CNOT2
uniprot id: A0A452FJ91
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9925:RB1
gene id: 9925:RB1
uniprot id: A0A452DQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9925:DIP2C
gene id: 9925:DIP2C
uniprot id: A0A452FYJ3
uniprot id: A0A452FYR7
names: Similarity
messages: Belongs to the DIP2 family.

9925:RPA3
gene id: 9925:RPA3
uniprot id: A0A452FTD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9925:SLC16A10
gene id: 9925:SLC16A10
uniprot id: A0A452FV81
names: Subcellular Location Annotation
messages: Membrane

9925:FGFR1OP2
gene id: 9925:FGFR1OP2
uniprot id: A0A452FEA4
uniprot id: A0A452FEE5
names: Similarity
messages: Belongs to the SIKE family.

9925:LOC102184740
gene id: 9925:LOC102184740
uniprot id: A0A452E0P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DSP
gene id: 9925:DSP
uniprot id: A0A452EHR7
names: Subcellular Location Annotation
messages: cytoskeleton

9925:HIF1A
gene id: 9925:HIF1A
uniprot id: G3LUM4
names: Subcellular Location Annotation
messages: Cytoplasm

9925:CAPZA2
gene id: 9925:CAPZA2
uniprot id: A0A452EHZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9925:OPA1
gene id: 9925:OPA1
uniprot id: A0A452EKR4
uniprot id: A0A452EKV7
uniprot id: A0A452EL01
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane