985053:VMUT RS06095
gene id: 985053:VMUT_RS06095
uniprot id: F0QYE8
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS08655
gene id: 985053:VMUT_RS08655
uniprot id: F0QUG7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

985053:VMUT RS01410
gene id: 985053:VMUT_RS01410
uniprot id: F0QTD8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

985053:VMUT RS02355
gene id: 985053:VMUT_RS02355
uniprot id: F0QUC1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

985053:VMUT RS10040
gene id: 985053:VMUT_RS10040
uniprot id: F0QVW9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

985053:VMUT RS07215
gene id: 985053:VMUT_RS07215
uniprot id: F0QT15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

985053:VMUT RS09370
gene id: 985053:VMUT_RS09370
uniprot id: F0QVB6
names: Similarity
messages: Belongs to the HypE family.

985053:VMUT RS03945
gene id: 985053:VMUT_RS03945
uniprot id: F0QW50
names: Similarity
messages: Belongs to the thioesterase PaaI family.

985053:VMUT RS01500
gene id: 985053:VMUT_RS01500
uniprot id: F0QTF4
names: Similarity
messages: Belongs to the citrate synthase family.

985053:VMUT RS02315
gene id: 985053:VMUT_RS02315
uniprot id: F0QUB3
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.

985053:VMUT RS00050
gene id: 985053:VMUT_RS00050
uniprot id: F0QYU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

985053:VMUT RS09095
gene id: 985053:VMUT_RS09095
uniprot id: F0QUY0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

985053:VMUT RS09000
gene id: 985053:VMUT_RS09000
uniprot id: F0QUW0
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

985053:VMUT RS11490
gene id: 985053:VMUT_RS11490
uniprot id: F0QXK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

985053:VMUT RS03900
gene id: 985053:VMUT_RS03900
uniprot id: F0QW42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

985053:VMUT RS11700
gene id: 985053:VMUT_RS11700
uniprot id: F0QXX5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS10775
gene id: 985053:VMUT_RS10775
uniprot id: F0QWR5
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

985053:VMUT RS00315
gene id: 985053:VMUT_RS00315
uniprot id: F0QSC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS07365
gene id: 985053:VMUT_RS07365
uniprot id: F0QT45
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS09275
gene id: 985053:VMUT_RS09275
uniprot id: F0QV96
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

985053:VMUT RS06185
gene id: 985053:VMUT_RS06185
uniprot id: F0QYG6
names: Subcellular Location Annotation
messages: Nucleus

985053:VMUT RS03305
gene id: 985053:VMUT_RS03305
uniprot id: F0QVJ5
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS03845
gene id: 985053:VMUT_RS03845
uniprot id: F0QW30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

985053:VMUT RS03750
gene id: 985053:VMUT_RS03750
uniprot id: F0QW12
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

985053:VMUT RS09205
gene id: 985053:VMUT_RS09205
uniprot id: F0QV02
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

985053:VMUT RS00535
gene id: 985053:VMUT_RS00535
uniprot id: F0QSG9
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS02245
gene id: 985053:VMUT_RS02245
uniprot id: F0QUA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

985053:VMUT RS02140
gene id: 985053:VMUT_RS02140
uniprot id: F0QU81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

985053:VMUT RS04680
gene id: 985053:VMUT_RS04680
uniprot id: F0QWZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

985053:VMUT RS02250
gene id: 985053:VMUT_RS02250
uniprot id: F0QUA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

985053:VMUT RS05850
gene id: 985053:VMUT_RS05850
uniprot id: F0QY96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

985053:VMUT RS09010
gene id: 985053:VMUT_RS09010
uniprot id: F0QUW2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS01915
gene id: 985053:VMUT_RS01915
uniprot id: F0QTW0
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

985053:VMUT RS01540
gene id: 985053:VMUT_RS01540
uniprot id: F0QTG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

985053:VMUT RS04685
gene id: 985053:VMUT_RS04685
uniprot id: F0QWZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

985053:VMUT RS04105
gene id: 985053:VMUT_RS04105
uniprot id: F0QWF8
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS04210
gene id: 985053:VMUT_RS04210
uniprot id: F0QWH7
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

985053:VMUT RS08775
gene id: 985053:VMUT_RS08775
uniprot id: F0QUJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

985053:VMUT RS04895
gene id: 985053:VMUT_RS04895
uniprot id: F0QXB8
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

985053:VMUT RS06075
gene id: 985053:VMUT_RS06075
uniprot id: F0QYE4
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS06205
gene id: 985053:VMUT_RS06205
uniprot id: F0QYH0
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS06510
gene id: 985053:VMUT_RS06510
uniprot id: F0QYN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

985053:VMUT RS11065
gene id: 985053:VMUT_RS11065
uniprot id: F0QX50
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

985053:VMUT RS06820
gene id: 985053:VMUT_RS06820
uniprot id: F0QSK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

985053:VMUT RS07095
gene id: 985053:VMUT_RS07095
uniprot id: F0QSR3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

985053:VMUT RS08555
gene id: 985053:VMUT_RS08555
uniprot id: F0QUE8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

985053:VMUT RS09280
gene id: 985053:VMUT_RS09280
uniprot id: F0QV97
names: Function
messages: Probably involved in the biogenesis of the ribosome.

985053:VMUT RS11650
gene id: 985053:VMUT_RS11650
uniprot id: F0QXN6
names: Cofactor
messages: Binds 2 divalent metal cations per subunit.

985053:VMUT RS03255
gene id: 985053:VMUT_RS03255
uniprot id: F0QVI5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

985053:VMUT RS01605
gene id: 985053:VMUT_RS01605
uniprot id: F0QTQ2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

985053:VMUT RS08335
gene id: 985053:VMUT_RS08335
uniprot id: F0QU33
names: Subcellular Location Annotation
messages: Nucleus

985053:VMUT RS06985
gene id: 985053:VMUT_RS06985
uniprot id: F0QSP1
names: Similarity
messages: Belongs to the thioesterase PaaI family.

985053:VMUT RS07245
gene id: 985053:VMUT_RS07245
uniprot id: F0QT21
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

985053:VMUT RS10870
gene id: 985053:VMUT_RS10870
uniprot id: F0QWT3
names: Similarity
messages: Belongs to the complex I subunit 3 family.

985053:VMUT RS05895
gene id: 985053:VMUT_RS05895
uniprot id: F0QYA5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS03950
gene id: 985053:VMUT_RS03950
uniprot id: F0QW51
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

985053:VMUT RS10645
gene id: 985053:VMUT_RS10645
uniprot id: F0QWN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

985053:VMUT RS04060
gene id: 985053:VMUT_RS04060
uniprot id: F0QWE9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

985053:VMUT RS04650
gene id: 985053:VMUT_RS04650
uniprot id: F0QWZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

985053:VMUT RS00320
gene id: 985053:VMUT_RS00320
uniprot id: F0QSC7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

985053:VMUT RS04975
gene id: 985053:VMUT_RS04975
uniprot id: F0QXD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

985053:VMUT RS03925
gene id: 985053:VMUT_RS03925
uniprot id: F0QW46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

985053:VMUT RS01070
gene id: 985053:VMUT_RS01070
uniprot id: F0QSZ9
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

985053:VMUT RS03050
gene id: 985053:VMUT_RS03050
uniprot id: F0QV64
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

985053:VMUT RS05060
gene id: 985053:VMUT_RS05060
uniprot id: F0QXF0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

985053:VMUT RS07935
gene id: 985053:VMUT_RS07935
uniprot id: F0QTM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

985053:VMUT RS01610
gene id: 985053:VMUT_RS01610
uniprot id: F0QTQ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

985053:VMUT RS10850
gene id: 985053:VMUT_RS10850
uniprot id: F0QWS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

985053:VMUT RS07910
gene id: 985053:VMUT_RS07910
uniprot id: F0QTM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS12020
gene id: 985053:VMUT_RS12020
uniprot id: F0QY28
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

985053:VMUT RS08005
gene id: 985053:VMUT_RS08005
uniprot id: F0QTP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

985053:VMUT RS09045
gene id: 985053:VMUT_RS09045
uniprot id: F0QUX0
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

985053:VMUT RS10560
gene id: 985053:VMUT_RS10560
uniprot id: F0QWM2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

985053:VMUT RS09415
gene id: 985053:VMUT_RS09415
uniprot id: F0QVC5
names: Similarity
messages: Belongs to the glutaredoxin family.

985053:VMUT RS04675
gene id: 985053:VMUT_RS04675
uniprot id: F0QWZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

985053:VMUT RS04345
gene id: 985053:VMUT_RS04345
uniprot id: F0QWK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

985053:VMUT RS09980
gene id: 985053:VMUT_RS09980
uniprot id: F0QVV7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS04435
gene id: 985053:VMUT_RS04435
uniprot id: F0QWU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

985053:VMUT RS07210
gene id: 985053:VMUT_RS07210
uniprot id: F0QT14
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

985053:VMUT RS03730
gene id: 985053:VMUT_RS03730
uniprot id: F0QW09
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

985053:VMUT RS07550
gene id: 985053:VMUT_RS07550
uniprot id: F0QT81
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

985053:VMUT RS10615
gene id: 985053:VMUT_RS10615
uniprot id: F0QWN3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS06800
gene id: 985053:VMUT_RS06800
uniprot id: F0QYT7
names: Similarity
messages: Belongs to the peptidase M24B family.

985053:VMUT RS03195
gene id: 985053:VMUT_RS03195
uniprot id: F0QVH3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS11050
gene id: 985053:VMUT_RS11050
uniprot id: F0QX47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

985053:VMUT RS04855
gene id: 985053:VMUT_RS04855
uniprot id: F0QXB1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

985053:VMUT RS06610
gene id: 985053:VMUT_RS06610
uniprot id: F0QYP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

985053:VMUT RS01680
gene id: 985053:VMUT_RS01680
uniprot id: F0QTR5
names: Similarity
messages: Belongs to the PrpD family.

985053:VMUT RS01590
gene id: 985053:VMUT_RS01590
uniprot id: F0QTP9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS04050
gene id: 985053:VMUT_RS04050
uniprot id: F0QWE7
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

985053:VMUT RS06755
gene id: 985053:VMUT_RS06755
uniprot id: F0QYS8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

985053:VMUT RS11870
gene id: 985053:VMUT_RS11870
uniprot id: F0QY02
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

985053:VMUT RS00610
gene id: 985053:VMUT_RS00610
uniprot id: F0QSI3
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS06540
gene id: 985053:VMUT_RS06540
uniprot id: F0QYN5
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

985053:VMUT RS00925
gene id: 985053:VMUT_RS00925
uniprot id: F0QSX2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

985053:VMUT RS06950
gene id: 985053:VMUT_RS06950
uniprot id: F0QSN4
names: Similarity
messages: Belongs to the HepT RNase toxin family.

985053:VMUT RS02835
gene id: 985053:VMUT_RS02835
uniprot id: F0QV23
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

985053:VMUT RS07085
gene id: 985053:VMUT_RS07085
uniprot id: F0QSR1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

985053:VMUT RS10145
gene id: 985053:VMUT_RS10145
uniprot id: F0QW67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

985053:VMUT RS10150
gene id: 985053:VMUT_RS10150
uniprot id: F0QW68
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

985053:VMUT RS03560
gene id: 985053:VMUT_RS03560
uniprot id: F0QVX4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

985053:VMUT RS01010
gene id: 985053:VMUT_RS01010
uniprot id: F0QSY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

985053:VMUT RS08170
gene id: 985053:VMUT_RS08170
uniprot id: F0QU02
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS02500
gene id: 985053:VMUT_RS02500
uniprot id: F0QUM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

985053:VMUT RS09535
gene id: 985053:VMUT_RS09535
uniprot id: F0QVE7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

985053:VMUT RS10910
gene id: 985053:VMUT_RS10910
uniprot id: F0QX19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

985053:VMUT RS02395
gene id: 985053:VMUT_RS02395
uniprot id: F0QUK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

985053:VMUT RS09005
gene id: 985053:VMUT_RS09005
uniprot id: F0QUW1
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

985053:VMUT RS03390
gene id: 985053:VMUT_RS03390
uniprot id: F0QVL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

985053:VMUT RS06850
gene id: 985053:VMUT_RS06850
uniprot id: F0QSL3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

985053:VMUT RS06150
gene id: 985053:VMUT_RS06150
uniprot id: F0QYF9
names: Similarity
messages: Belongs to the HepT RNase toxin family.

985053:VMUT RS03965
gene id: 985053:VMUT_RS03965
uniprot id: F0QWD0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

985053:VMUT RS02470
gene id: 985053:VMUT_RS02470
uniprot id: F0QUM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

985053:VMUT RS08665
gene id: 985053:VMUT_RS08665
uniprot id: F0QUG9
names: Similarity
messages: Belongs to the UPF0173 family.

985053:VMUT RS02040
gene id: 985053:VMUT_RS02040
uniprot id: F0QU61
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

985053:VMUT RS04165
gene id: 985053:VMUT_RS04165
uniprot id: F0QWH0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

985053:VMUT RS09985
gene id: 985053:VMUT_RS09985
uniprot id: F0QVV8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

985053:VMUT RS11480
gene id: 985053:VMUT_RS11480
uniprot id: F0QXK4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS00025
gene id: 985053:VMUT_RS00025
uniprot id: F0QYU1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

985053:VMUT RS09240
gene id: 985053:VMUT_RS09240
uniprot id: F0QV89
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS06255
gene id: 985053:VMUT_RS06255
uniprot id: F0QYI0
names: Similarity
messages: Belongs to the UDPGP type 2 family.

985053:VMUT RS10170
gene id: 985053:VMUT_RS10170
uniprot id: F0QW72
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

985053:VMUT RS00680
gene id: 985053:VMUT_RS00680
uniprot id: F0QSJ6
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

985053:VMUT RS02005
gene id: 985053:VMUT_RS02005
uniprot id: F0QU54
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

985053:VMUT RS07390
gene id: 985053:VMUT_RS07390
uniprot id: F0QT50
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

985053:VMUT RS04350
gene id: 985053:VMUT_RS04350
uniprot id: F0QWK5
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

985053:VMUT RS03180
gene id: 985053:VMUT_RS03180
uniprot id: F0QVH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

985053:VMUT RS10630
gene id: 985053:VMUT_RS10630
uniprot id: F0QWN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

985053:VMUT RS07785
gene id: 985053:VMUT_RS07785
uniprot id: F0QTK1
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS06090
gene id: 985053:VMUT_RS06090
uniprot id: F0QYE7
names: Similarity
messages: Belongs to the AOR/FOR family.

985053:VMUT RS03285
gene id: 985053:VMUT_RS03285
uniprot id: F0QVJ1
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

985053:VMUT RS06200
gene id: 985053:VMUT_RS06200
uniprot id: F0QYG9
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

985053:VMUT RS03445
gene id: 985053:VMUT_RS03445
uniprot id: F0QVM3
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

985053:VMUT RS06770
gene id: 985053:VMUT_RS06770
uniprot id: F0QYT1
names: Similarity
messages: Belongs to the RuvB family.

985053:VMUT RS08410
gene id: 985053:VMUT_RS08410
uniprot id: F0QU45
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

985053:VMUT RS06270
gene id: 985053:VMUT_RS06270
uniprot id: F0QYI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

985053:VMUT RS00435
gene id: 985053:VMUT_RS00435
uniprot id: F0QSF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

985053:VMUT RS06390
gene id: 985053:VMUT_RS06390
uniprot id: F0QYK7
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.

985053:VMUT RS04805
gene id: 985053:VMUT_RS04805
uniprot id: F0QXA2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

985053:VMUT RS10660
gene id: 985053:VMUT_RS10660
uniprot id: F0QWP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

985053:VMUT RS04665
gene id: 985053:VMUT_RS04665
uniprot id: F0QWZ5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

985053:VMUT RS11380
gene id: 985053:VMUT_RS11380
uniprot id: F0QXI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

985053:VMUT RS09210
gene id: 985053:VMUT_RS09210
uniprot id: F0QV03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

985053:VMUT RS04520
gene id: 985053:VMUT_RS04520
uniprot id: F0QWW7
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

985053:VMUT RS01125
gene id: 985053:VMUT_RS01125
uniprot id: F0QT10
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

985053:VMUT RS03150
gene id: 985053:VMUT_RS03150
uniprot id: F0QV86
names: Similarity
messages: Belongs to the class-I fumarase family.

985053:VMUT RS03995
gene id: 985053:VMUT_RS03995
uniprot id: F0QWD6
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS11310
gene id: 985053:VMUT_RS11310
uniprot id: F0QXH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

985053:VMUT RS10225
gene id: 985053:VMUT_RS10225
uniprot id: F0QW83
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

985053:VMUT RS06415
gene id: 985053:VMUT_RS06415
uniprot id: F0QYL2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

985053:VMUT RS03450
gene id: 985053:VMUT_RS03450
uniprot id: F0QVM4
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

985053:VMUT RS09485
gene id: 985053:VMUT_RS09485
uniprot id: F0QVD8
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS08515
gene id: 985053:VMUT_RS08515
uniprot id: F0QUE0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

985053:VMUT RS10190
gene id: 985053:VMUT_RS10190
uniprot id: F0QW76
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

985053:VMUT RS01460
gene id: 985053:VMUT_RS01460
uniprot id: F0QTE7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

985053:VMUT RS09290
gene id: 985053:VMUT_RS09290
uniprot id: F0QVA0
names: Similarity
messages: Belongs to the UPF0440 family.

985053:VMUT RS02050
gene id: 985053:VMUT_RS02050
uniprot id: F0QU63
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

985053:VMUT RS10585
gene id: 985053:VMUT_RS10585
uniprot id: F0QWM7
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

985053:VMUT RS07000
gene id: 985053:VMUT_RS07000
uniprot id: F0QSP4
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

985053:VMUT RS12115
gene id: 985053:VMUT_RS12115
uniprot id: F0QY47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

985053:VMUT RS02690
gene id: 985053:VMUT_RS02690
uniprot id: F0QUR6
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

985053:VMUT RS07835
gene id: 985053:VMUT_RS07835
uniprot id: F0QTK9
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

985053:VMUT RS06930
gene id: 985053:VMUT_RS06930
uniprot id: F0QSM9
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS04980
gene id: 985053:VMUT_RS04980
uniprot id: F0QXD4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

985053:VMUT RS10605
gene id: 985053:VMUT_RS10605
uniprot id: F0QWN1
names: Similarity
messages: Belongs to the CutA family.

985053:VMUT RS06570
gene id: 985053:VMUT_RS06570
uniprot id: F0QYP1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

985053:VMUT RS01705
gene id: 985053:VMUT_RS01705
uniprot id: F0QTS0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

985053:VMUT RS06815
gene id: 985053:VMUT_RS06815
uniprot id: F0QSK6
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

985053:VMUT RS01965
gene id: 985053:VMUT_RS01965
uniprot id: F0QTW9
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

985053:VMUT RS06065
gene id: 985053:VMUT_RS06065
uniprot id: F0QYE2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

985053:VMUT RS04110
gene id: 985053:VMUT_RS04110
uniprot id: F0QWF9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

985053:VMUT RS06455
gene id: 985053:VMUT_RS06455
uniprot id: F0QYM0
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS11580
gene id: 985053:VMUT_RS11580
uniprot id: F0QXM2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

985053:VMUT RS06305
gene id: 985053:VMUT_RS06305
uniprot id: F0QYJ0
names: Caution
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

985053:VMUT RS01130
gene id: 985053:VMUT_RS01130
uniprot id: F0QT11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

985053:VMUT RS01380
gene id: 985053:VMUT_RS01380
uniprot id: F0QTD2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

985053:VMUT RS00475
gene id: 985053:VMUT_RS00475
uniprot id: F0QSF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

985053:VMUT RS06720
gene id: 985053:VMUT_RS06720
uniprot id: F0QYS1
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS06100
gene id: 985053:VMUT_RS06100
uniprot id: F0QYE9
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

985053:VMUT RS08000
gene id: 985053:VMUT_RS08000
uniprot id: F0QTP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

985053:VMUT RS07865
gene id: 985053:VMUT_RS07865
uniprot id: F0QTL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

985053:VMUT RS01430
gene id: 985053:VMUT_RS01430
uniprot id: F0QTE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

985053:VMUT RS07065
gene id: 985053:VMUT_RS07065
uniprot id: F0QSQ7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

985053:VMUT RS01395
gene id: 985053:VMUT_RS01395
uniprot id: F0QTD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

985053:VMUT RS00430
gene id: 985053:VMUT_RS00430
uniprot id: F0QSE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

985053:VMUT RS01425
gene id: 985053:VMUT_RS01425
uniprot id: F0QTE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

985053:VMUT RS05840
gene id: 985053:VMUT_RS05840
uniprot id: F0QY94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm

985053:VMUT RS03065
gene id: 985053:VMUT_RS03065
uniprot id: F0QV67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

985053:VMUT RS10195
gene id: 985053:VMUT_RS10195
uniprot id: F0QW77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

985053:VMUT RS10590
gene id: 985053:VMUT_RS10590
uniprot id: F0QWM8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

985053:VMUT RS02465
gene id: 985053:VMUT_RS02465
uniprot id: F0QUM2
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

985053:VMUT RS03120
gene id: 985053:VMUT_RS03120
uniprot id: F0QV79
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

985053:VMUT RS03040
gene id: 985053:VMUT_RS03040
uniprot id: F0QV62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

985053:VMUT RS02300
gene id: 985053:VMUT_RS02300
uniprot id: F0QUA9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

985053:VMUT RS02680
gene id: 985053:VMUT_RS02680
uniprot id: F0QUR4
names: Similarity
messages: Belongs to the Ahb/Nir family.

985053:VMUT RS10810
gene id: 985053:VMUT_RS10810
uniprot id: F0QWS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

985053:VMUT RS06665
gene id: 985053:VMUT_RS06665
uniprot id: F0QYR0
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

985053:VMUT RS07485
gene id: 985053:VMUT_RS07485
uniprot id: F0QT68
names: Similarity
messages: Belongs to the HerA family.

985053:VMUT RS03095
gene id: 985053:VMUT_RS03095
uniprot id: F0QV73
names: Function
messages: Part of a potassium transport system.

985053:VMUT RS02015
gene id: 985053:VMUT_RS02015
uniprot id: F0QU56
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

985053:VMUT RS12120
gene id: 985053:VMUT_RS12120
uniprot id: F0QY48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

985053:VMUT RS10005
gene id: 985053:VMUT_RS10005
uniprot id: F0QVW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

985053:VMUT RS06005
gene id: 985053:VMUT_RS06005
uniprot id: F0QYD1
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS11110
gene id: 985053:VMUT_RS11110
uniprot id: F0QX59
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS03430
gene id: 985053:VMUT_RS03430
uniprot id: F0QVM0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

985053:VMUT RS07335
gene id: 985053:VMUT_RS07335
uniprot id: F0QT39
names: Similarity
messages: Belongs to the TrpC family.

985053:VMUT RS06340
gene id: 985053:VMUT_RS06340
uniprot id: F0QYJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

985053:VMUT RS02095
gene id: 985053:VMUT_RS02095
uniprot id: F0QU71
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS00595
gene id: 985053:VMUT_RS00595
uniprot id: F0QSI0
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

985053:VMUT RS08125
gene id: 985053:VMUT_RS08125
uniprot id: F0QTZ3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

985053:VMUT RS04860
gene id: 985053:VMUT_RS04860
uniprot id: F0QXB2
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS04125
gene id: 985053:VMUT_RS04125
uniprot id: F0QWG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

985053:VMUT RS02270
gene id: 985053:VMUT_RS02270
uniprot id: F0QUA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

985053:VMUT RS00720
gene id: 985053:VMUT_RS00720
uniprot id: F0QST4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

985053:VMUT RS01750
gene id: 985053:VMUT_RS01750
uniprot id: F0QTS8
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS10765
gene id: 985053:VMUT_RS10765
uniprot id: F0QWR3
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

985053:VMUT RS10745
gene id: 985053:VMUT_RS10745
uniprot id: F0QWQ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS11925
gene id: 985053:VMUT_RS11925
uniprot id: F0QY11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

985053:VMUT RS06980
gene id: 985053:VMUT_RS06980
uniprot id: F0QSP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

985053:VMUT RS08810
gene id: 985053:VMUT_RS08810
uniprot id: F0QUJ7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

985053:VMUT RS07940
gene id: 985053:VMUT_RS07940
uniprot id: F0QTM9
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

985053:VMUT RS06190
gene id: 985053:VMUT_RS06190
uniprot id: F0QYG7
names: Similarity
messages: Belongs to the MCM family.

985053:VMUT RS09345
gene id: 985053:VMUT_RS09345
uniprot id: F0QVB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

985053:VMUT RS09125
gene id: 985053:VMUT_RS09125
uniprot id: F0QUY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

985053:VMUT RS03735
gene id: 985053:VMUT_RS03735
uniprot id: F0QW10
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS03100
gene id: 985053:VMUT_RS03100
uniprot id: F0QV74
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

985053:VMUT RS10770
gene id: 985053:VMUT_RS10770
uniprot id: F0QWR4
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS04215
gene id: 985053:VMUT_RS04215
uniprot id: F0QWH8
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

985053:VMUT RS08745
gene id: 985053:VMUT_RS08745
uniprot id: F0QUI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

985053:VMUT RS02200
gene id: 985053:VMUT_RS02200
uniprot id: F0QU92
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

985053:VMUT RS02515
gene id: 985053:VMUT_RS02515
uniprot id: F0QUN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

985053:VMUT RS03880
gene id: 985053:VMUT_RS03880
uniprot id: F0QW38
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

985053:VMUT RS10000
gene id: 985053:VMUT_RS10000
uniprot id: F0QVW1
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

985053:VMUT RS07110
gene id: 985053:VMUT_RS07110
uniprot id: F0QSR6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

985053:VMUT RS06300
gene id: 985053:VMUT_RS06300
uniprot id: F0QYI9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

985053:VMUT RS11020
gene id: 985053:VMUT_RS11020
uniprot id: F0QX41
names: Similarity
messages: Belongs to the HerA family.

985053:VMUT RS04630
gene id: 985053:VMUT_RS04630
uniprot id: F0QWY8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

985053:VMUT RS02450
gene id: 985053:VMUT_RS02450
uniprot id: F0QUL9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

985053:VMUT RS01470
gene id: 985053:VMUT_RS01470
uniprot id: F0QTE9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

985053:VMUT RS02525
gene id: 985053:VMUT_RS02525
uniprot id: F0QUN2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

985053:VMUT RS03175
gene id: 985053:VMUT_RS03175
uniprot id: F0QVG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

985053:VMUT RS04575
gene id: 985053:VMUT_RS04575
uniprot id: F0QWX8
names: Similarity
messages: Belongs to the DMRL synthase family.

985053:VMUT RS03930
gene id: 985053:VMUT_RS03930
uniprot id: F0QW47
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

985053:VMUT RS06585
gene id: 985053:VMUT_RS06585
uniprot id: F0QYP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

985053:VMUT RS03340
gene id: 985053:VMUT_RS03340
uniprot id: F0QVK1
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

985053:VMUT RS06285
gene id: 985053:VMUT_RS06285
uniprot id: F0QYI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

985053:VMUT RS02895
gene id: 985053:VMUT_RS02895
uniprot id: F0QV34
names: Similarity
messages: Belongs to the glutaredoxin family.

985053:VMUT RS03360
gene id: 985053:VMUT_RS03360
uniprot id: F0QVK4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

985053:VMUT RS09635
gene id: 985053:VMUT_RS09635
uniprot id: F0QVG6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

985053:VMUT RS04725
gene id: 985053:VMUT_RS04725
uniprot id: F0QX07
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

985053:VMUT RS12040
gene id: 985053:VMUT_RS12040
uniprot id: F0QY32
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

985053:VMUT RS11550
gene id: 985053:VMUT_RS11550
uniprot id: F0QXL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

985053:VMUT RS03115
gene id: 985053:VMUT_RS03115
uniprot id: F0QV78
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

985053:VMUT RS01405
gene id: 985053:VMUT_RS01405
uniprot id: F0QTD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

985053:VMUT RS02975
gene id: 985053:VMUT_RS02975
uniprot id: F0QV50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

985053:VMUT RS02025
gene id: 985053:VMUT_RS02025
uniprot id: F0QU58
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

985053:VMUT RS00930
gene id: 985053:VMUT_RS00930
uniprot id: F0QST8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

985053:VMUT RS10025
gene id: 985053:VMUT_RS10025
uniprot id: F0QVW6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

985053:VMUT RS06840
gene id: 985053:VMUT_RS06840
uniprot id: F0QSL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

985053:VMUT RS04465
gene id: 985053:VMUT_RS04465
uniprot id: F0QWV6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

985053:VMUT RS12050
gene id: 985053:VMUT_RS12050
uniprot id: F0QY34
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

985053:VMUT RS10010
gene id: 985053:VMUT_RS10010
uniprot id: F0QVW3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

985053:VMUT RS02635
gene id: 985053:VMUT_RS02635
uniprot id: F0QUQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

985053:VMUT RS01685
gene id: 985053:VMUT_RS01685
uniprot id: F0QTR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

985053:VMUT RS09040
gene id: 985053:VMUT_RS09040
uniprot id: F0QUW9
names: Similarity
messages: Belongs to the UPF0201 family.

985053:VMUT RS01295
gene id: 985053:VMUT_RS01295
uniprot id: F0QTB8
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

985053:VMUT RS09230
gene id: 985053:VMUT_RS09230
uniprot id: F0QV07
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS11235
gene id: 985053:VMUT_RS11235
uniprot id: F0QX83
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

985053:VMUT RS09090
gene id: 985053:VMUT_RS09090
uniprot id: F0QUX9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

985053:VMUT RS04120
gene id: 985053:VMUT_RS04120
uniprot id: F0QWG1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

985053:VMUT RS01935
gene id: 985053:VMUT_RS01935
uniprot id: F0QTW3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

985053:VMUT RS00145
gene id: 985053:VMUT_RS00145
uniprot id: F0QYW3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

985053:VMUT RS12045
gene id: 985053:VMUT_RS12045
uniprot id: F0QY33
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

985053:VMUT RS02035
gene id: 985053:VMUT_RS02035
uniprot id: F0QU60
names: Similarity
messages: Belongs to the UPF0179 family.

985053:VMUT RS05720
gene id: 985053:VMUT_RS05720
uniprot id: F0QY70
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS08290
gene id: 985053:VMUT_RS08290
uniprot id: F0QU25
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

985053:VMUT RS01820
gene id: 985053:VMUT_RS01820
uniprot id: F0QTU2
names: Similarity
messages: Belongs to the arginase family.

985053:VMUT RS08350
gene id: 985053:VMUT_RS08350
uniprot id: F0QU36
names: Similarity
messages: Belongs to the ZPR1 family.

985053:VMUT RS03155
gene id: 985053:VMUT_RS03155
uniprot id: F0QV87
names: Similarity
messages: Belongs to the class-I fumarase family.

985053:VMUT RS06055
gene id: 985053:VMUT_RS06055
uniprot id: F0QYE0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

985053:VMUT RS03705
gene id: 985053:VMUT_RS03705
uniprot id: F0QW03
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

985053:VMUT RS04780
gene id: 985053:VMUT_RS04780
uniprot id: F0QX97
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
messages: Belongs to the methylmalonyl-CoA epimerase family.

985053:VMUT RS09285
gene id: 985053:VMUT_RS09285
uniprot id: F0QV99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

985053:VMUT RS00990
gene id: 985053:VMUT_RS00990
uniprot id: F0QSY4
names: Similarity
messages: Belongs to the peptidase M24B family.

985053:VMUT RS07315
gene id: 985053:VMUT_RS07315
uniprot id: F0QT35
names: Similarity
messages: Belongs to the TrpF family.

985053:VMUT RS04425
gene id: 985053:VMUT_RS04425
uniprot id: F0QWU7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

985053:VMUT RS03055
gene id: 985053:VMUT_RS03055
uniprot id: F0QV65
names: Similarity
messages: Belongs to the AOR/FOR family.

985053:VMUT RS05515
gene id: 985053:VMUT_RS05515
uniprot id: F0QXV8
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

985053:VMUT RS03605
gene id: 985053:VMUT_RS03605
uniprot id: F0QVY3
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS07900
gene id: 985053:VMUT_RS07900
uniprot id: F0QTM2
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

985053:VMUT RS10035
gene id: 985053:VMUT_RS10035
uniprot id: F0QVW8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS10100
gene id: 985053:VMUT_RS10100
uniprot id: F0QW58
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS06895
gene id: 985053:VMUT_RS06895
uniprot id: F0QSM2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

985053:VMUT RS03275
gene id: 985053:VMUT_RS03275
uniprot id: F0QVI9
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

985053:VMUT RS03000
gene id: 985053:VMUT_RS03000
uniprot id: F0QV55
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

985053:VMUT RS06025
gene id: 985053:VMUT_RS06025
uniprot id: F0QYD5
names: Similarity
messages: Belongs to the AOR/FOR family.

985053:VMUT RS06625
gene id: 985053:VMUT_RS06625
uniprot id: F0QYQ2
names: Similarity
messages: Belongs to the glutamate synthase family.

985053:VMUT RS08265
gene id: 985053:VMUT_RS08265
uniprot id: F0QU20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

985053:VMUT RS06330
gene id: 985053:VMUT_RS06330
uniprot id: F0QYJ5
names: Similarity
messages: Belongs to the UPF0047 family.

985053:VMUT RS12095
gene id: 985053:VMUT_RS12095
uniprot id: F0QY43
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS07345
gene id: 985053:VMUT_RS07345
uniprot id: F0QT41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

985053:VMUT RS06695
gene id: 985053:VMUT_RS06695
uniprot id: F0QYR6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS02045
gene id: 985053:VMUT_RS02045
uniprot id: F0QU62
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

985053:VMUT RS09100
gene id: 985053:VMUT_RS09100
uniprot id: F0QUY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

985053:VMUT RS10975
gene id: 985053:VMUT_RS10975
uniprot id: F0QX32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

985053:VMUT RS04595
gene id: 985053:VMUT_RS04595
uniprot id: F0QWY2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

985053:VMUT RS11510
gene id: 985053:VMUT_RS11510
uniprot id: F0QXL0
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS07220
gene id: 985053:VMUT_RS07220
uniprot id: F0QT16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

985053:VMUT RS04965
gene id: 985053:VMUT_RS04965
uniprot id: F0QXD1
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

985053:VMUT RS04135
gene id: 985053:VMUT_RS04135
uniprot id: F0QWG4
names: Similarity
messages: Belongs to the type IA topoisomerase family.

985053:VMUT RS01120
gene id: 985053:VMUT_RS01120
uniprot id: F0QT09
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

985053:VMUT RS00795
gene id: 985053:VMUT_RS00795
uniprot id: F0QSU6
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS00480
gene id: 985053:VMUT_RS00480
uniprot id: F0QSF8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

985053:VMUT RS07775
gene id: 985053:VMUT_RS07775
uniprot id: F0QTJ9
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

985053:VMUT RS02100
gene id: 985053:VMUT_RS02100
uniprot id: F0QU72
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

985053:VMUT RS10230
gene id: 985053:VMUT_RS10230
uniprot id: F0QW84
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

985053:VMUT RS01815
gene id: 985053:VMUT_RS01815
uniprot id: F0QTU1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

985053:VMUT RS03920
gene id: 985053:VMUT_RS03920
uniprot id: F0QW45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

985053:VMUT RS00310
gene id: 985053:VMUT_RS00310
uniprot id: F0QYZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

985053:VMUT RS10580
gene id: 985053:VMUT_RS10580
uniprot id: F0QWM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

985053:VMUT RS09115
gene id: 985053:VMUT_RS09115
uniprot id: F0QUY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

985053:VMUT RS11230
gene id: 985053:VMUT_RS11230
uniprot id: F0QX82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

985053:VMUT RS07790
gene id: 985053:VMUT_RS07790
uniprot id: F0QTK2
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS03405
gene id: 985053:VMUT_RS03405
uniprot id: F0QVL5
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS08270
gene id: 985053:VMUT_RS08270
uniprot id: F0QU21
names: Similarity
messages: Belongs to the carbamate kinase family.

985053:VMUT RS01515
gene id: 985053:VMUT_RS01515
uniprot id: F0QTF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

985053:VMUT RS08690
gene id: 985053:VMUT_RS08690
uniprot id: F0QUH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

985053:VMUT RS01560
gene id: 985053:VMUT_RS01560
uniprot id: F0QTP3
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

985053:VMUT RS08100
gene id: 985053:VMUT_RS08100
uniprot id: F0QTY8
names: Similarity
messages: Belongs to the glutamine synthetase family.

985053:VMUT RS06240
gene id: 985053:VMUT_RS06240
uniprot id: F0QYH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

985053:VMUT RS04085
gene id: 985053:VMUT_RS04085
uniprot id: F0QWF3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS04990
gene id: 985053:VMUT_RS04990
uniprot id: F0QXD6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

985053:VMUT RS06515
gene id: 985053:VMUT_RS06515
uniprot id: F0QYN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

985053:VMUT RS05855
gene id: 985053:VMUT_RS05855
uniprot id: F0QY97
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

985053:VMUT RS04700
gene id: 985053:VMUT_RS04700
uniprot id: F0QX02
names: Subcellular Location Annotation
messages: Cell membrane

985053:VMUT RS10940
gene id: 985053:VMUT_RS10940
uniprot id: F0QX25
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

985053:VMUT RS04840
gene id: 985053:VMUT_RS04840
uniprot id: F0QXA8
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

985053:VMUT RS01840
gene id: 985053:VMUT_RS01840
uniprot id: F0QTU6
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS09105
gene id: 985053:VMUT_RS09105
uniprot id: F0QUY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

985053:VMUT RS04280
gene id: 985053:VMUT_RS04280
uniprot id: F0QWJ1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

985053:VMUT RS10655
gene id: 985053:VMUT_RS10655
uniprot id: F0QWP1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

985053:VMUT RS08150
gene id: 985053:VMUT_RS08150
uniprot id: F0QTZ8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

985053:VMUT RS09140
gene id: 985053:VMUT_RS09140
uniprot id: F0QUZ0
names: Similarity
messages: Belongs to the HAM1 NTPase family.

985053:VMUT RS02330
gene id: 985053:VMUT_RS02330
uniprot id: F0QUB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

985053:VMUT RS08570
gene id: 985053:VMUT_RS08570
uniprot id: F0QUF1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

985053:VMUT RS05055
gene id: 985053:VMUT_RS05055
uniprot id: F0QXE9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

985053:VMUT RS12015
gene id: 985053:VMUT_RS12015
uniprot id: F0QY27
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

985053:VMUT RS06810
gene id: 985053:VMUT_RS06810
uniprot id: F0QSK5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

985053:VMUT RS03520
gene id: 985053:VMUT_RS03520
uniprot id: F0QVN8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

985053:VMUT RS04955
gene id: 985053:VMUT_RS04955
uniprot id: F0QXC9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

985053:VMUT RS09845
gene id: 985053:VMUT_RS09845
uniprot id: F0QVT3
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS08435
gene id: 985053:VMUT_RS08435
uniprot id: F0QUC7
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Heterodimer of the IorA and IorB subunits.

985053:VMUT RS02440
gene id: 985053:VMUT_RS02440
uniprot id: F0QUL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

985053:VMUT RS05795
gene id: 985053:VMUT_RS05795
uniprot id: F0QY85
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

985053:VMUT RS06685
gene id: 985053:VMUT_RS06685
uniprot id: F0QYR4
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS01025
gene id: 985053:VMUT_RS01025
uniprot id: F0QSZ0
names: Caution
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS01350
gene id: 985053:VMUT_RS01350
uniprot id: F0QTC6
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

985053:VMUT RS09180
gene id: 985053:VMUT_RS09180
uniprot id: F0QUZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

985053:VMUT RS02435
gene id: 985053:VMUT_RS02435
uniprot id: F0QUL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

985053:VMUT RS10960
gene id: 985053:VMUT_RS10960
uniprot id: F0QX29
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

985053:VMUT RS00685
gene id: 985053:VMUT_RS00685
uniprot id: F0QSJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

985053:VMUT RS06295
gene id: 985053:VMUT_RS06295
uniprot id: F0QYI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

985053:VMUT RS03570
gene id: 985053:VMUT_RS03570
uniprot id: F0QVX6
names: Similarity
messages: Belongs to the Nth/MutY family.

985053:VMUT RS06280
gene id: 985053:VMUT_RS06280
uniprot id: F0QYI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS03715
gene id: 985053:VMUT_RS03715
uniprot id: F0QW06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

985053:VMUT RS00755
gene id: 985053:VMUT_RS00755
uniprot id: F0QST8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

985053:VMUT RS02865
gene id: 985053:VMUT_RS02865
uniprot id: F0QV28
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

985053:VMUT RS08330
gene id: 985053:VMUT_RS08330
uniprot id: F0QU32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

985053:VMUT RS02460
gene id: 985053:VMUT_RS02460
uniprot id: F0QUM1
names: Similarity
messages: Belongs to the eIF-2-alpha family.

985053:VMUT RS08245
gene id: 985053:VMUT_RS08245
uniprot id: F0QU16
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

985053:VMUT RS06235
gene id: 985053:VMUT_RS06235
uniprot id: F0QYH6
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS00640
gene id: 985053:VMUT_RS00640
uniprot id: F0QSI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

985053:VMUT RS02760
gene id: 985053:VMUT_RS02760
uniprot id: F0QV08
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

985053:VMUT RS01115
gene id: 985053:VMUT_RS01115
uniprot id: F0QT08
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

985053:VMUT RS09135
gene id: 985053:VMUT_RS09135
uniprot id: F0QUY9
names: Similarity
messages: Belongs to the glutaredoxin family.

985053:VMUT RS10245
gene id: 985053:VMUT_RS10245
uniprot id: F0QW87
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

985053:VMUT RS04500
gene id: 985053:VMUT_RS04500
uniprot id: F0QWW3
names: Similarity
messages: Belongs to the AOR/FOR family.

985053:VMUT RS08980
gene id: 985053:VMUT_RS08980
uniprot id: F0QUV6
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

985053:VMUT RS04940
gene id: 985053:VMUT_RS04940
uniprot id: F0QXC6
names: Similarity
messages: Belongs to the AOR/FOR family.

985053:VMUT RS09250
gene id: 985053:VMUT_RS09250
uniprot id: F0QV91
names: Similarity
messages: Belongs to the HerA family.

985053:VMUT RS07355
gene id: 985053:VMUT_RS07355
uniprot id: F0QT43
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS03810
gene id: 985053:VMUT_RS03810
uniprot id: F0QW24
names: Similarity
messages: Belongs to the PGI/PMI family.

985053:VMUT RS01555
gene id: 985053:VMUT_RS01555
uniprot id: F0QTG6
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

985053:VMUT RS09610
gene id: 985053:VMUT_RS09610
uniprot id: F0QVG1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

985053:VMUT RS03765
gene id: 985053:VMUT_RS03765
uniprot id: F0QW15
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

985053:VMUT RS10880
gene id: 985053:VMUT_RS10880
uniprot id: F0QWT5
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

985053:VMUT RS00205
gene id: 985053:VMUT_RS00205
uniprot id: F0QYX5
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

985053:VMUT RS11150
gene id: 985053:VMUT_RS11150
uniprot id: F0QX67
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

985053:VMUT RS06620
gene id: 985053:VMUT_RS06620
uniprot id: F0QYQ1
names: Subcellular Location Annotation
messages: Cell membrane

985053:VMUT RS04795
gene id: 985053:VMUT_RS04795
uniprot id: F0QXA0
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

985053:VMUT RS07965
gene id: 985053:VMUT_RS07965
uniprot id: F0QTN4
names: Subunit
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

985053:VMUT RS00255
gene id: 985053:VMUT_RS00255
uniprot id: F0QYY4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

985053:VMUT RS00800
gene id: 985053:VMUT_RS00800
uniprot id: F0QSU7
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS07675
gene id: 985053:VMUT_RS07675
uniprot id: F0QTI2
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

985053:VMUT RS01940
gene id: 985053:VMUT_RS01940
uniprot id: F0QTW4
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

985053:VMUT RS00690
gene id: 985053:VMUT_RS00690
uniprot id: F0QSJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

985053:VMUT RS09995
gene id: 985053:VMUT_RS09995
uniprot id: F0QVW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

985053:VMUT RS04010
gene id: 985053:VMUT_RS04010
uniprot id: F0QWD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

985053:VMUT RS08965
gene id: 985053:VMUT_RS08965
uniprot id: F0QUV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

985053:VMUT RS08695
gene id: 985053:VMUT_RS08695
uniprot id: F0QUH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

985053:VMUT RS11100
gene id: 985053:VMUT_RS11100
uniprot id: F0QX57
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS09970
gene id: 985053:VMUT_RS09970
uniprot id: F0QVV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

985053:VMUT RS09805
gene id: 985053:VMUT_RS09805
uniprot id: F0QVS6
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS09380
gene id: 985053:VMUT_RS09380
uniprot id: F0QVB8
names: Similarity
messages: Belongs to the RutC family.

985053:VMUT RS02195
gene id: 985053:VMUT_RS02195
uniprot id: F0QU91
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

985053:VMUT RS09035
gene id: 985053:VMUT_RS09035
uniprot id: F0QUW8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

985053:VMUT RS08675
gene id: 985053:VMUT_RS08675
uniprot id: F0QUH1
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

985053:VMUT RS08075
gene id: 985053:VMUT_RS08075
uniprot id: F0QTY3
names: Similarity
messages: Belongs to the pyruvate kinase family.

985053:VMUT RS04030
gene id: 985053:VMUT_RS04030
uniprot id: F0QWE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

985053:VMUT RS08960
gene id: 985053:VMUT_RS08960
uniprot id: F0QUV2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

985053:VMUT RS02520
gene id: 985053:VMUT_RS02520
uniprot id: F0QUN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

985053:VMUT RS04235
gene id: 985053:VMUT_RS04235
uniprot id: F0QWI2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

985053:VMUT RS01600
gene id: 985053:VMUT_RS01600
uniprot id: F0QTQ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

985053:VMUT RS04890
gene id: 985053:VMUT_RS04890
uniprot id: F0QXB7
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS07320
gene id: 985053:VMUT_RS07320
uniprot id: F0QT36
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS02285
gene id: 985053:VMUT_RS02285
uniprot id: F0QUA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

985053:VMUT RS03535
gene id: 985053:VMUT_RS03535
uniprot id: F0QVP1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

985053:VMUT RS04845
gene id: 985053:VMUT_RS04845
uniprot id: F0QXA9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

985053:VMUT RS07950
gene id: 985053:VMUT_RS07950
uniprot id: F0QTN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

985053:VMUT RS03495
gene id: 985053:VMUT_RS03495
uniprot id: F0QVN3
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS04295
gene id: 985053:VMUT_RS04295
uniprot id: F0QWJ4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

985053:VMUT RS09640
gene id: 985053:VMUT_RS09640
uniprot id: F0QVP5
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

985053:VMUT RS04240
gene id: 985053:VMUT_RS04240
uniprot id: F0QWI3
names: Similarity
messages: Belongs to the SfsA family.

985053:VMUT RS03160
gene id: 985053:VMUT_RS03160
uniprot id: F0QVG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

985053:VMUT RS01775
gene id: 985053:VMUT_RS01775
uniprot id: F0QTT3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

985053:VMUT RS02420
gene id: 985053:VMUT_RS02420
uniprot id: F0QUL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

985053:VMUT RS10710
gene id: 985053:VMUT_RS10710
uniprot id: F0QWQ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

985053:VMUT RS09375
gene id: 985053:VMUT_RS09375
uniprot id: F0QVB7
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

985053:VMUT RS04750
gene id: 985053:VMUT_RS04750
uniprot id: F0QX12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

985053:VMUT RS06425
gene id: 985053:VMUT_RS06425
uniprot id: F0QYL4
names: Similarity
messages: Belongs to the AOR/FOR family.

985053:VMUT RS07275
gene id: 985053:VMUT_RS07275
uniprot id: F0QT27
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

985053:VMUT RS08340
gene id: 985053:VMUT_RS08340
uniprot id: F0QU34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

985053:VMUT RS10395
gene id: 985053:VMUT_RS10395
uniprot id: F0QWB3
names: Similarity
messages: Belongs to the HepT RNase toxin family.

985053:VMUT RS03970
gene id: 985053:VMUT_RS03970
uniprot id: F0QWD1
names: Similarity
messages: Belongs to the UPF0282 family.

985053:VMUT RS08530
gene id: 985053:VMUT_RS08530
uniprot id: F0QUE3
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

985053:VMUT RS00295
gene id: 985053:VMUT_RS00295
uniprot id: F0QYZ2
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS07075
gene id: 985053:VMUT_RS07075
uniprot id: F0QSQ9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

985053:VMUT RS08645
gene id: 985053:VMUT_RS08645
uniprot id: F0QUG5
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

985053:VMUT RS05265
gene id: 985053:VMUT_RS05265
uniprot id: F0QXQ9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

985053:VMUT RS09220
gene id: 985053:VMUT_RS09220
uniprot id: F0QV05
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS09515
gene id: 985053:VMUT_RS09515
uniprot id: F0QVE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

985053:VMUT RS09190
gene id: 985053:VMUT_RS09190
uniprot id: F0QUZ9
names: Similarity
messages: Belongs to the malic enzymes family.

985053:VMUT RS06545
gene id: 985053:VMUT_RS06545
uniprot id: F0QYN6
names: Subcellular Location Annotation
messages: Cytoplasm

985053:VMUT RS06385
gene id: 985053:VMUT_RS06385
uniprot id: F0QYK6
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS03320
gene id: 985053:VMUT_RS03320
uniprot id: F0QVJ7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

985053:VMUT RS07420
gene id: 985053:VMUT_RS07420
uniprot id: F0QT55
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS03580
gene id: 985053:VMUT_RS03580
uniprot id: F0QVX8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

985053:VMUT RS01545
gene id: 985053:VMUT_RS01545
uniprot id: F0QTG4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

985053:VMUT RS09465
gene id: 985053:VMUT_RS09465
uniprot id: F0QVD5
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS03400
gene id: 985053:VMUT_RS03400
uniprot id: F0QVL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 large subunit family.
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

985053:VMUT RS08680
gene id: 985053:VMUT_RS08680
uniprot id: F0QUH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

985053:VMUT RS09585
gene id: 985053:VMUT_RS09585
uniprot id: F0QVF6
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

985053:VMUT RS02335
gene id: 985053:VMUT_RS02335
uniprot id: F0QUB7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

985053:VMUT RS00775
gene id: 985053:VMUT_RS00775
uniprot id: F0QSU2
names: Similarity
messages: Belongs to the thymidylate kinase family.

985053:VMUT RS06960
gene id: 985053:VMUT_RS06960
uniprot id: F0QSN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

985053:VMUT RS04970
gene id: 985053:VMUT_RS04970
uniprot id: F0QXD2
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

985053:VMUT RS11450
gene id: 985053:VMUT_RS11450
uniprot id: F0QXJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

985053:VMUT RS09120
gene id: 985053:VMUT_RS09120
uniprot id: F0QUY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

985053:VMUT RS05890
gene id: 985053:VMUT_RS05890
uniprot id: F0QYA4
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

985053:VMUT RS08760
gene id: 985053:VMUT_RS08760
uniprot id: F0QUI7
names: Similarity
messages: Belongs to the SDO1/SBDS family.

985053:VMUT RS02415
gene id: 985053:VMUT_RS02415
uniprot id: F0QUL2
names: Similarity
messages: Belongs to the PDCD5 family.

985053:VMUT RS12445
gene id: 985053:VMUT_RS12445
uniprot id: F0QW32
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

985053:VMUT RS07280
gene id: 985053:VMUT_RS07280
uniprot id: F0QT28
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

985053:VMUT RS00170
gene id: 985053:VMUT_RS00170
uniprot id: F0QYW8
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS08640
gene id: 985053:VMUT_RS08640
uniprot id: F0QUG4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

985053:VMUT RS04055
gene id: 985053:VMUT_RS04055
uniprot id: F0QWE8
names: Similarity
messages: Belongs to the arginase family.

985053:VMUT RS06210
gene id: 985053:VMUT_RS06210
uniprot id: F0QYH1
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS11940
gene id: 985053:VMUT_RS11940
uniprot id: F0QY14
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

985053:VMUT RS10175
gene id: 985053:VMUT_RS10175
uniprot id: F0QW73
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS01810
gene id: 985053:VMUT_RS01810
uniprot id: F0QTU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

985053:VMUT RS07860
gene id: 985053:VMUT_RS07860
uniprot id: F0QTL4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS00055
gene id: 985053:VMUT_RS00055
uniprot id: F0QYU7
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS02145
gene id: 985053:VMUT_RS02145
uniprot id: F0QU82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

985053:VMUT RS02030
gene id: 985053:VMUT_RS02030
uniprot id: F0QU59
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

985053:VMUT RS10600
gene id: 985053:VMUT_RS10600
uniprot id: F0QWN0
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

985053:VMUT RS07330
gene id: 985053:VMUT_RS07330
uniprot id: F0QT38
names: Function
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

985053:VMUT RS07080
gene id: 985053:VMUT_RS07080
uniprot id: F0QSR0
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Heterodimer composed of an alpha and a beta subunit.

985053:VMUT RS02795
gene id: 985053:VMUT_RS02795
uniprot id: F0QV15
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS00115
gene id: 985053:VMUT_RS00115
uniprot id: F0QYV7
names: Similarity
messages: Belongs to the peptidase S45 family.

985053:VMUT RS01030
gene id: 985053:VMUT_RS01030
uniprot id: F0QSZ1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

985053:VMUT RS11025
gene id: 985053:VMUT_RS11025
uniprot id: F0QX42
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS03240
gene id: 985053:VMUT_RS03240
uniprot id: F0QVI2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS06250
gene id: 985053:VMUT_RS06250
uniprot id: F0QYH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

985053:VMUT RS04170
gene id: 985053:VMUT_RS04170
uniprot id: F0QWH1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS00460
gene id: 985053:VMUT_RS00460
uniprot id: F0QSF4
names: Similarity
messages: Belongs to the peptidase M1 family.

985053:VMUT RS11285
gene id: 985053:VMUT_RS11285
uniprot id: F0QX93
names: Similarity
messages: Belongs to the peptidase U62 family.

985053:VMUT RS02255
gene id: 985053:VMUT_RS02255
uniprot id: F0QUA2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

985053:VMUT RS06835
gene id: 985053:VMUT_RS06835
uniprot id: F0QSL0
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

985053:VMUT RS06565
gene id: 985053:VMUT_RS06565
uniprot id: F0QYP0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

985053:VMUT RS11755
gene id: 985053:VMUT_RS11755
uniprot id: F0QXY4
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS04760
gene id: 985053:VMUT_RS04760
uniprot id: F0QX14
names: Similarity
messages: Belongs to the AOR/FOR family.

985053:VMUT RS02675
gene id: 985053:VMUT_RS02675
uniprot id: F0QUR3
names: Subcellular Location Annotation
messages: Membrane

985053:VMUT RS01160
gene id: 985053:VMUT_RS01160
uniprot id: F0QT96
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.