9823:NFYB
gene id: 9823:NFYB
uniprot id: A0A480YZR3
uniprot id: A0A4X1T8K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9823:RLN3
gene id: 9823:RLN3
uniprot id: Q8HY17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: May play a role in neuropeptide signaling processes. Ligand for LGR7, RXFP3 and RXFP4 (By similarity).
messages: Secreted

9823:SIX2
gene id: 9823:SIX2
uniprot id: A0A4X1SIW3
uniprot id: F1S5K5
names: Subcellular Location Annotation
messages: Nucleus

9823:PTPRZ1
gene id: 9823:PTPRZ1
uniprot id: A0A286ZVC4
uniprot id: A0A287BQK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9823:DTX4
gene id: 9823:DTX4
uniprot id: A0A287AIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9823:PAFAH1B1
gene id: 9823:PAFAH1B1
uniprot id: A0A480UJL5
uniprot id: A0A4X1UCH0
uniprot id: Q9GL51
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity. Interacts with the catalytic dimer of PAF-AH (I) heterotetrameric enzyme: interacts with PAFAH1B2 homodimer (alpha2/alpha2 homodimer), PAFAH1B3 homodimer (alpha1/alpha1 homodimer) and PAFAH1B2-PAFAH1B3 heterodimer (alpha2/alpha1 heterodimer) (By similarity). Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Interacts with INTS13. Interacts with DCDC1.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity).
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

9823:KIF2C
gene id: 9823:KIF2C
uniprot id: A0A287B0M5
uniprot id: A0A480QBR9
uniprot id: A0A4X1W9C9
uniprot id: A0A8D0JLL7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:IYD
gene id: 9823:IYD
uniprot id: Q6TA49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nitroreductase family.
messages: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (By similarity). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438). The scavanged iodide can then reenter the hormone-producing pathways (By similarity). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (By similarity).
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Detected in thyroid (at protein level).
messages: Homodimer.

9823:TUBB1
gene id: 9823:TUBB1
uniprot id: A0A8D1LU54
uniprot id: A5GFX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:SLC5A4
gene id: 9823:SLC5A4
uniprot id: P31636
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Has electrogenic activity in response to glucose, and may function as a glucose sensor (PubMed:8077195). Also has low-affinity sodium/glucose cotransporter activity; sugar transport activity is tightly coupled to ion transport at neutral pH but is reduced under more acidic conditions (PubMed:8077195, PubMed:13130073).
messages: Inhibited by phlorizin.
messages: Kidney, intestine, liver, skeletal muscle and spleen.
messages: Was originally thought to be a sodium/neutral amino acid cotransporter (system a neutral amino acid transporter) responsible for the sodium-dependent intake of neutral amino acids such as alanine, glycine, serine, cysteine, and proline.

9823:KCNJ9
gene id: 9823:KCNJ9
uniprot id: A0A5G2R5J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9823:STATH
gene id: 9823:STATH
uniprot id: D8WUT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

9823:IRF1
gene id: 9823:IRF1
uniprot id: A0FIN4
uniprot id: D2KC06
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by MYD88.
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer (By similarity). Homodimer (By similarity). Interacts with EP300 (By similarity). Interacts with MYD88 (By similarity). Interacts with PIAS3 (By similarity).
messages: Nucleus
messages: Phosphorylated by CK2 and this positively regulates its activity.
messages: Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation (By similarity). Sumolyated by UBE2I/UBC9 and SUMO1 (By similarity). Inactivates the tumor suppressor activity (By similarity). Elevated levels in tumor cells. Major site is Lys-276 (By similarity). Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites (By similarity).
messages: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (By similarity). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (By similarity). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Binds to a consensus sequence in gene promoters (By similarity). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (By similarity). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (By similarity). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (By similarity). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation o…
messages: Ubiquitinated. Appears to compete with sumoylation on C-terminal sites (By similarity).

9823:LOC100523309
gene id: 9823:LOC100523309
uniprot id: A0A4X1VVD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RAG1
gene id: 9823:RAG1
uniprot id: A0A481A9F8
uniprot id: Q867B5
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated in the presence of CDC34/UBCH3.
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitinat…
messages: Homodimer.
messages: Homodimer. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts with DCAF1, leading to recruitment of the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to ubiquitinate proteins and limit error-prone repair during V(D)J recombination (By similarity).
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.
messages: The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity.

9823:GFM1
gene id: 9823:GFM1
uniprot id: A0A480EKY5
uniprot id: A0A4X1SGR9
uniprot id: A0A4X1SGY0
uniprot id: I3LKJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9823:RPL13A
gene id: 9823:RPL13A
uniprot id: A0A287B929
uniprot id: A0A4X1VYE4
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9823:SCAMP1
gene id: 9823:SCAMP1
uniprot id: O77735
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAMP family.
messages: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
messages: Interacts with SYNRG, ITSN1 and SLC9A7.
messages: Recycling endosome membrane
messages: trans-Golgi network membrane

9823:C6
gene id: 9823:C6
uniprot id: A0SEH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:HTRA3
gene id: 9823:HTRA3
uniprot id: D3K5L5
names: Similarity
messages: Belongs to the peptidase S1C family.

9823:CP
gene id: 9823:CP
uniprot id: A0A287A718
uniprot id: A0A4X1T1D8
uniprot id: A0A8D1LFT0
uniprot id: I3VKE6
uniprot id: K7GKN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9823:SDR16C5
gene id: 9823:SDR16C5
uniprot id: A0A4X1ST96
uniprot id: D3K5L0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:GPX1
gene id: 9823:GPX1
uniprot id: Q8MJ14
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutathione peroxidase family.
messages: Cytoplasm
messages: During periods of oxidative stress, Sec-52 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.
messages: Homotetramer. Interacts with MIEN1 (By similarity).
messages: Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism.

9823:ETFDH
gene id: 9823:ETFDH
uniprot id: A0A286ZXI8
uniprot id: A0A8D1R7K8
uniprot id: A0A8D1RC92
uniprot id: F1RW89
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9823:PRKAB2
gene id: 9823:PRKAB2
uniprot id: A0A4X1SNK1
uniprot id: F1SDB6
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9823:SLC31A2
gene id: 9823:SLC31A2
uniprot id: A0A4X1V5L2
uniprot id: A0A4X1V6N4
uniprot id: F1SN90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9823:BLOC1S3
gene id: 9823:BLOC1S3
uniprot id: A5A769
uniprot id: M3VK25
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S3 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity).
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Interacts directly with BLOC1S2. Interacts with BLOC1S4, BLOC1S5 and BLOC1S6 (By similarity).
messages: Cytoplasm
messages: Phosphorylated.

9823:KAT6B
gene id: 9823:KAT6B
uniprot id: A0A286ZID3
uniprot id: A0A287AGG6
uniprot id: A0A8D0X009
uniprot id: A0A8D1ST71
uniprot id: A0A8D1X774
uniprot id: F1S2G4
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

9823:SLC24A5
gene id: 9823:SLC24A5
uniprot id: A0A4X1SFS1
uniprot id: F1SN62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9823:LPAR4
gene id: 9823:LPAR4
uniprot id: A0A4X1UEM6
uniprot id: A0A8D0NBH2
uniprot id: F1RPF6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:CASP10
gene id: 9823:CASP10
uniprot id: C1PIJ2
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:PGLYRP1
gene id: 9823:PGLYRP1
uniprot id: Q6PKY6
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9823:SLA-6
gene id: 9823:SLA-6
uniprot id: Q8MHU1
names: Similarity
messages: Belongs to the MHC class I family.

9823:CTSC
gene id: 9823:CTSC
uniprot id: A0A4X1U3C8
uniprot id: F1STR1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9823:KCNN3
gene id: 9823:KCNN3
uniprot id: A0A480JK39
uniprot id: P58392
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
messages: Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:11877319). Activation is followed by membrane hyperpolarization (PubMed:11877319). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (PubMed:11877319).
messages: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). Interacts with CALM1 (By similarity).
messages: Inhibited by bee venom neurotoxin apamin.
messages: Membrane

9823:KLHL21
gene id: 9823:KLHL21
uniprot id: A0A480RGQ1
names: Subcellular Location Annotation
messages: spindle

9823:TAF9
gene id: 9823:TAF9
uniprot id: A0A287AFL9
uniprot id: A0A4X1UHC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9823:SLC25A17
gene id: 9823:SLC25A17
uniprot id: A0A287B1G7
uniprot id: A0A4X1W0U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:APRT
gene id: 9823:APRT
uniprot id: A0A4X1TEA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

9823:MOV10
gene id: 9823:MOV10
uniprot id: A0A480I372
uniprot id: A0A4X1T6V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9823:CPO
gene id: 9823:CPO
uniprot id: A0A287B4Y3
uniprot id: A0A8D1IA37
names: Similarity
messages: Belongs to the peptidase M14 family.

9823:RFC1
gene id: 9823:RFC1
uniprot id: A0A8D0YJM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

9823:CCDC130
gene id: 9823:CCDC130
uniprot id: A0A8D0UTV6
names: Similarity
messages: Belongs to the CWC16 family.

9823:GOSR2
gene id: 9823:GOSR2
uniprot id: A0A287BIC8
uniprot id: A0A4X1TDL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9823:LOC110255196
gene id: 9823:LOC110255196
uniprot id: A0A4X1TZD1
uniprot id: A0A5G2QYJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CASP1
gene id: 9823:CASP1
uniprot id: Q9N2I1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cell membrane
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NLRP2 and whose function would be the activation of pro-inflammatory caspases. Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis). Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17P/INCA and CARD18. Interacts with SERPINB1; this interaction regulates CASP1 activity.
messages: The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
messages: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.
messages: Ubiquitinated via 'Lys-11'-linked polyubiquitination. Deubiquitinated by USP8.

9823:NDUFA5
gene id: 9823:NDUFA5
uniprot id: A0A287BAW0
uniprot id: A0A4X1VWT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:NDUFS8
gene id: 9823:NDUFS8
uniprot id: A0A287BJQ2
uniprot id: A0A4X1SVK9
uniprot id: A0A8D2C1R2
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

9823:IMPA1
gene id: 9823:IMPA1
uniprot id: O77591
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inositol monophosphatase superfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM.
messages: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.

9823:DLD
gene id: 9823:DLD
uniprot id: P09623
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Expressed in heart (at protein level).
messages: Homodimer. Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDHA (PDHA1 or PDHA2) and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (by non covalent bonds). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with PDHX.
messages: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: The active site is a redox-active disulfide bond.
messages: Tyrosine phosphorylated.
messages: acrosome
messages: flagellum

9823:GNRH1
gene id: 9823:GNRH1
uniprot id: B0ZYW9
uniprot id: P49921
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
messages: The precursor is cleaved by ACE, which removes the Gly-Lys-Arg peptide at the C-terminus, leading to mature hormone. The mature form of Gonadoliberin-1 is also cleaved and degraded by ACE.

9823:CREB3L4
gene id: 9823:CREB3L4
uniprot id: A0A8D0N8N6
uniprot id: A0A8D1LGR7
uniprot id: B0LI00
uniprot id: F1RFX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:NPTX1
gene id: 9823:NPTX1
uniprot id: A0A4X1UHZ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CFB
gene id: 9823:CFB
uniprot id: A0A8D0Q4G6
uniprot id: A5PF00
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:MYOD1
gene id: 9823:MYOD1
uniprot id: D2KPI9
uniprot id: P49811
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).
messages: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1. Interacts with DDX5. Interacts with CHD2. Interacts with TSC22D3 (By similarity). Interacts with SETD3 (By similarity). Interacts with P-TEFB complex; promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation (By similarity). Interacts with CSRP3 (By similarity). Interacts with NUPR1 (By similarity).
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity.
messages: Nucleus
messages: Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation (By similarity).
messages: Ubiquitinated on the N-terminus; which is required for proteasomal degradation.

9823:FABP7
gene id: 9823:FABP7
uniprot id: A0A8D1H8Y4
uniprot id: A4D7T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9823:TMCC3
gene id: 9823:TMCC3
uniprot id: A0A8D0U876
names: Similarity
messages: Belongs to the TEX28 family.

9823:FEN1
gene id: 9823:FEN1
uniprot id: A0A4X1VNN0
uniprot id: F1RKS3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9823:CRB2
gene id: 9823:CRB2
uniprot id: A0A8D0RS61
uniprot id: F1SKU3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:S100A6
gene id: 9823:S100A6
uniprot id: Q2EN75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Interacts with TPPP; this interaction inhibits TPPP dimerization (By similarity).
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).
messages: Nucleus envelope

9823:STX10
gene id: 9823:STX10
uniprot id: A0A4X1T0P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9823:COPB2
gene id: 9823:COPB2
uniprot id: A0A4X1TS96
uniprot id: F1SL54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

9823:THRA
gene id: 9823:THRA
uniprot id: A0A480Q663
uniprot id: O97716
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D. Interacts with AKAP13. Interacts with TP53INP2. Interacts with PER2 (By similarity). Interacts with PER2. Isoform alpha-2 and isoform alpha-1 interact with TACC1, but the interaction with alpha-1 is weaker. The interaction with isoform alpha-1, but not alpha-2, is decreased in the presence of thyroid hormone T3 (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Does not bind thyroid hormone T3.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus

9823:TRPV3
gene id: 9823:TRPV3
uniprot id: A0A4X1UCB6
names: Subcellular Location Annotation
messages: Membrane

9823:RARRES1
gene id: 9823:RARRES1
uniprot id: A0A5G2QJW9
uniprot id: A0A8D0PWW4
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9823:NEIL1
gene id: 9823:NEIL1
uniprot id: A0A287A8W2
uniprot id: A0A4X1TT87
names: Similarity
messages: Belongs to the FPG family.

9823:ACOT8
gene id: 9823:ACOT8
uniprot id: A0A4X1U116
uniprot id: I3LA89
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9823:WDR12
gene id: 9823:WDR12
uniprot id: A0A4X1V7X7
uniprot id: F1SHE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9823:RAD23B
gene id: 9823:RAD23B
uniprot id: A0A480DNV8
uniprot id: A0A4X1VCP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9823:MRPL27
gene id: 9823:MRPL27
uniprot id: A0A4X1U0F6
uniprot id: F1RT79
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9823:ORMDL1
gene id: 9823:ORMDL1
uniprot id: A0A8D1R3F7
uniprot id: F1RXU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9823:CCR5
gene id: 9823:CCR5
uniprot id: A0A4X1TA26
uniprot id: Q6YT41
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:IFNE
gene id: 9823:IFNE
uniprot id: A7UHZ5
uniprot id: C8CKC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted
messages: Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).

9823:SLC10A1
gene id: 9823:SLC10A1
uniprot id: A0A8D0ZAJ9
uniprot id: F1S4B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9823:ITGB5
gene id: 9823:ITGB5
uniprot id: G3FNU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9823:ACTA1
gene id: 9823:ACTA1
uniprot id: A0A480QNI6
uniprot id: P68137
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with alpha-actinin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with TTID. Interacts (via its C-terminus) with USP25 (By similarity).
messages: cytoskeleton

9823:SIKE1
gene id: 9823:SIKE1
uniprot id: A0A8D0PLE5
uniprot id: F1SBS2
names: Similarity
messages: Belongs to the SIKE family.

9823:TAGLN
gene id: 9823:TAGLN
uniprot id: A0A4X1SX44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

9823:ADIPOR2
gene id: 9823:ADIPOR2
uniprot id: A0A4X1UF86
uniprot id: Q5UVJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:GJA1
gene id: 9823:GJA1
uniprot id: A0A4X1TJW2
uniprot id: F1SF43
uniprot id: Q9GJX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:UGDH
gene id: 9823:UGDH
uniprot id: A0A8D1VHY8
uniprot id: I3LIM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9823:SCD
gene id: 9823:SCD
uniprot id: O02858
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
messages: The histidine box domains are involved in binding the catalytic metal ions.

9823:PLIN5
gene id: 9823:PLIN5
uniprot id: A0A4X1VLU6
uniprot id: B1PHQ9
names: Similarity
messages: Belongs to the perilipin family.

9823:TMEM106B
gene id: 9823:TMEM106B
uniprot id: A0A4X1TN99
names: Similarity
messages: Belongs to the TMEM106 family.

9823:ORAI3
gene id: 9823:ORAI3
uniprot id: A0A4X1TL02
uniprot id: F1RG82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9823:TRIM32
gene id: 9823:TRIM32
uniprot id: A0A8D0ND79
uniprot id: F1SMI2
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9823:PTK2B
gene id: 9823:PTK2B
uniprot id: A0A8D1FYV2
uniprot id: A0A8D1NH71
uniprot id: F1RJS6
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9823:EFEMP1
gene id: 9823:EFEMP1
uniprot id: A0A286ZJ45
uniprot id: A0A480STR6
uniprot id: A0A8D1HWV6
uniprot id: F8SIP2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ST6GALNAC2
gene id: 9823:ST6GALNAC2
uniprot id: A0A4X1UXI0
uniprot id: F1RWP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:SDF4
gene id: 9823:SDF4
uniprot id: A0A287ACL1
uniprot id: A0A4X1W9A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

9823:PEPD
gene id: 9823:PEPD
uniprot id: A0A8D1LAP7
uniprot id: F1RNW4
names: Similarity
messages: Belongs to the peptidase M24B family.

9823:SIDT2
gene id: 9823:SIDT2
uniprot id: A0A286ZN25
uniprot id: A0A4X1SY28
uniprot id: A0A4X1SYJ8
uniprot id: A0A5G2RB28
uniprot id: F1SJS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9823:PHOSPHO1
gene id: 9823:PHOSPHO1
uniprot id: A0A8D1S613
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9823:LOC100523732
gene id: 9823:LOC100523732
uniprot id: A0A4X1U284
names: Subcellular Location Annotation
messages: Membrane

9823:MYO6
gene id: 9823:MYO6
uniprot id: A0A480QP12
uniprot id: A0A4X1V011
uniprot id: A0A4X1V0K6
uniprot id: Q29122
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Divided into three regions: a N-terminal motor (head) domain, followed by a neck domain consisting of a calmodulin-binding linker domain and a single IQ motif, and a C-terminal tail region with a three-helix bundle region, a SAH domain and a unique globular domain required for interaction with other proteins such as cargo-binding.
messages: Expressed in all tissues examined including kidney cortex, intestinal mucosa, liver, lung, heart, jowl muscle, brain cortex and medulla, and in the epithelial cell line, LLC-PK1 (at protein level) (PubMed:7929586). In the kidney, located to the brush border of adult kidney proximal tubule cells (PubMed:7929586).
messages: Golgi apparatus
messages: Homodimer; dimerization seems to implicate the unfolding of the three-helix bundle region creating an additional calmodulin binding site, and cargo binding (PubMed:25159143, PubMed:19664948). Component of the DISP/DOCK7-induced septin displacement complex, at least composed of DOCK7, LRCH3 and MYO6 (By similarity). Able to function as a monomer under specific conditions in vitro (By similarity). Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells (By similarity). Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal (PubMed:15037754). This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium (PubMed:12682054, PubMed:15037754). Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (PubMed:7929586). Interacts with DAB2 (By similarity). In vitro, the C-terminal globular tail binds a C-terminal region of DAB2 (By similarity). Interacts with CFTR (By similarity). Interacts with CABP5 (By similarity). Interacts (via residues 1117-1245) with TOM1 (via residues 392-463) (By similarity). Interacts (via residues 1060-1285) with OPTN (By similarity). Interacts (via residues 1060-1285) with TAX1BP1 and CALCOCO2/NDP52 (By similarity). Interacts with TOM1L2 (By similarity).
messages: Locates to the apical domain only during the final stages of kidney proximal tubule development.
messages: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (PubMed:15944696). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (PubMed:16917816). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (By similarity). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (By similarity). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (By similarity). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (By similarity). May act as a regulator of F-actin dynamics (PubMed:7929586). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (By similarity).
messages: Nucleus
messages: Originally predicted to contain a coiled coil domain but generally accepted to contain a stable SAH domain instead.
messages: Phosphorylation in the motor domain, induced by EGF, results in translocation of MYO6 from the cell surface to membrane ruffles and affects F-actin dynamics. Phosphorylated in vitro by p21-activated kinase (PAK).
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-6 (MYH6).
messages: The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. Its contribution to the mechanism confering the myosin movement on actin filaments is debated.
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: cytosol
messages: filopodium
messages: microvillus
messages: perinuclear region
messages: ruffle membrane
messages: trans-Golgi network membrane

9823:ZSCAN29
gene id: 9823:ZSCAN29
uniprot id: A0A4X1V700
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9823:LOC102166306
gene id: 9823:LOC102166306
uniprot id: A0A287BB29
uniprot id: A0A287BP58
uniprot id: A0A8D0R2R5
uniprot id: A0A8D1KMX2
names: Subcellular Location Annotation
messages: Secreted

9823:ZP2
gene id: 9823:ZP2
uniprot id: P42099
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ZP domain family. ZPA subfamily.
messages: Can form homopolymers that assemble into long fibers (in vitro). Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. Interacts with ZP3.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
messages: Expressed in oocytes.
messages: N-glycosylated.
messages: O-glycosylated; contains sulfate-substituted glycans.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9823:MAML1
gene id: 9823:MAML1
uniprot id: A0A4X1VX41
uniprot id: F1S442
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9823:AP5M1
gene id: 9823:AP5M1
uniprot id: A0A287B4H1
uniprot id: A0A4X1WE24
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9823:RETREG1
gene id: 9823:RETREG1
uniprot id: A0A480E929
uniprot id: A0A4X1TQI4
uniprot id: A0A5G2QGI7
uniprot id: A0A8D1VYE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9823:AMACR
gene id: 9823:AMACR
uniprot id: A0A4X1TFH2
names: Similarity
messages: Belongs to the CoA-transferase III family.

9823:ICAM1
gene id: 9823:ICAM1
uniprot id: A0A4X1V623
uniprot id: Q9MZU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9823:NFKB1
gene id: 9823:NFKB1
uniprot id: Q0PHA8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:FAM219B
gene id: 9823:FAM219B
uniprot id: A0A4X1TP85
uniprot id: F1SJ31
names: Similarity
messages: Belongs to the FAM219 family.

9823:LYPLA2
gene id: 9823:LYPLA2
uniprot id: A0A8D1JDU7
uniprot id: I3LHP2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9823:NPPA
gene id: 9823:NPPA
uniprot id: A0A8D1LZQ1
uniprot id: F1RF79
uniprot id: P24259
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the natriuretic peptide family.
messages: Brain (at protein level).
messages: Cell projection
messages: Cleavage by MME initiates degradation of the factor and thereby regulates its activity. Degradation by IDE results in reduced activation of NPR1 (in vitro). During IDE degradation, the resulting products can temporarily stimulate NPR2 to produce cGMP, before the fragments are completely degraded and inactivated by IDE (in vitro).
messages: Degraded by IDE.
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.
messages: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (By similarity). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (PubMed:2964562). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity).
messages: May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity).
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Perikaryon
messages: Phosphorylation on Ser-128 decreases vasorelaxant activity.
messages: Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, a heterologous and in vivo expression study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).
messages: Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, an in vivo study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).
messages: Secreted
messages: The precursor molecule is proteolytically cleaved by CORIN at Arg-122 to produce the atrial natriuretic peptide (By similarity). Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide (By similarity). Additional processing gives rise to the auriculin and atriopeptin peptides (By similarity). In the kidneys, alternative processing by an unknown protease results in the peptide urodilatin (By similarity).

9823:ABAT
gene id: 9823:ABAT
uniprot id: P80147
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 [2Fe-2S] cluster per homodimer.
messages: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
messages: Homodimer; disulfide-linked.
messages: Mitochondrion matrix

9823:SFT2D1
gene id: 9823:SFT2D1
uniprot id: A0A4X1VWQ2
uniprot id: F1SBY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9823:NPY2R
gene id: 9823:NPY2R
uniprot id: A0A4X1SUG7
uniprot id: F1RYR8
uniprot id: O02836
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY.

9823:CSAD
gene id: 9823:CSAD
uniprot id: A0A287AHB5
uniprot id: A0A8D0PLY3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9823:PLK5
gene id: 9823:PLK5
uniprot id: A0A8D1DKX4
uniprot id: F1SDI4
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9823:CDH11
gene id: 9823:CDH11
uniprot id: A0A4X1UU14
uniprot id: F1RFU7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9823:PDK3
gene id: 9823:PDK3
uniprot id: A0A287AHT1
uniprot id: A0A4X1VEY5
uniprot id: A0A4X1VF39
uniprot id: A0A5G2RN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9823:RBKS
gene id: 9823:RBKS
uniprot id: G8ENM3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9823:TMEM87A
gene id: 9823:TMEM87A
uniprot id: A0A287B758
uniprot id: A0A4X1V0Q1
uniprot id: A0A8D1KST2
uniprot id: F1SFK6
names: Subcellular Location Annotation
messages: Membrane

9823:SRP68
gene id: 9823:SRP68
uniprot id: A0A4X1UYD0
uniprot id: A0A5G2RD86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9823:ORAI2
gene id: 9823:ORAI2
uniprot id: A0A4X1UHY0
uniprot id: F1RKF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9823:DFNB59
gene id: 9823:DFNB59
uniprot id: A0A480MQ05
uniprot id: A0A4X1UGI8
names: Similarity
messages: Belongs to the gasdermin family.

9823:SLC35C2
gene id: 9823:SLC35C2
uniprot id: A0A287BSR3
uniprot id: A0A4X1U4I4
names: Subcellular Location Annotation
messages: Membrane

9823:PIGB
gene id: 9823:PIGB
uniprot id: A0A286ZQB9
uniprot id: A0A4X1TER5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9823:SHOC2
gene id: 9823:SHOC2
uniprot id: A0A287B795
uniprot id: A0A4X1TBB7
uniprot id: A0A4X1TD38
uniprot id: F2Z5G0
names: Function
names: Similarity
messages: Belongs to the SHOC2 family.
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

9823:OGG1
gene id: 9823:OGG1
uniprot id: A0A4X1UWX2
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9823:PARP9
gene id: 9823:PARP9
uniprot id: A0A8D1RY71
names: Similarity
messages: Belongs to the ARTD/PARP family.

9823:LOC100524947
gene id: 9823:LOC100524947
uniprot id: A0A4X1VHK3
uniprot id: F1S9N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MATK
gene id: 9823:MATK
uniprot id: A0A286ZM95
uniprot id: A0A287B8P3
uniprot id: A0A4X1VMB6
uniprot id: A0A8D1MC18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:PKIA
gene id: 9823:PKIA
uniprot id: Q71U53
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
messages: The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and 'pseudosubstrate site' of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site (By similarity).

9823:CPLX4
gene id: 9823:CPLX4
uniprot id: A0A4X1TPW0
uniprot id: F1SMS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9823:ACRBP
gene id: 9823:ACRBP
uniprot id: F1SL45
uniprot id: Q29016
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome (PubMed:8144514). Involved also in the acrosome formation (By similarity).
messages: Binds specifically to the 55- and 53-kDa proacrosins and the 49-kDa acrosin intermediate, but is not capable of binding 43-kDa acrosin intermediate and 32-kDa mature acrosin.
messages: Phosphorylated on Tyr residues in capacitated sperm.
messages: Secreted
messages: Specifically expressed in testis.
messages: Synthesized as a 60-kDa precursor, the 35-kDa mature form is post-translationally produced by the removal of the N-terminal half of the precursor during sperm maturation in the testis and/or epididymis.
messages: The N-terminus is blocked.
messages: acrosome

9823:RGS5
gene id: 9823:RGS5
uniprot id: A0A480ZJZ5
uniprot id: Q864Z2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
messages: Membrane

9823:TM4SF4
gene id: 9823:TM4SF4
uniprot id: A0A4X1SXZ5
uniprot id: F1SJP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9823:PSMB10
gene id: 9823:PSMB10
uniprot id: A0A4X1UH60
uniprot id: Q1W2K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:MB21D2
gene id: 9823:MB21D2
uniprot id: A0A4X1U8F8
uniprot id: F1SFH0
names: Similarity
messages: Belongs to the mab-21 family.

9823:RBM17
gene id: 9823:RBM17
uniprot id: A0A4X1T7S8
uniprot id: F1RUL1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9823:NFS1
gene id: 9823:NFS1
uniprot id: A0A4X1TC78
uniprot id: B6UV57
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9823:EDC4
gene id: 9823:EDC4
uniprot id: F1S2J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9823:NGB
gene id: 9823:NGB
uniprot id: Q6WZ17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the globin family.
messages: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes (By similarity).
messages: Monomer. Homodimer and homotetramer; disulfide-linked.
messages: Perikaryon

9823:EPC1
gene id: 9823:EPC1
uniprot id: A0A286ZVH4
uniprot id: A0A4X1UEB2
uniprot id: A0A4X1UET2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9823:PSMB3
gene id: 9823:PSMB3
uniprot id: A0A286ZN52
uniprot id: A0A4X1ULL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:STMN1
gene id: 9823:STMN1
uniprot id: Q6DUB7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the stathmin family.
messages: Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST (By similarity).
messages: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
messages: Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity).
messages: cytoskeleton

9823:LTB4R2
gene id: 9823:LTB4R2
uniprot id: A0A8D1HZQ6
uniprot id: I3LIW2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:MAP3K7
gene id: 9823:MAP3K7
uniprot id: A0A4X1VKJ4
uniprot id: B0LXP5
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9823:CXCR4
gene id: 9823:CXCR4
uniprot id: Q764M9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Late endosome
messages: Lysosome
messages: Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
messages: O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.
messages: Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-325 and Ser-326 leads to recruitment of ITCH, ubiquitination and protein degradation.
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).
messages: Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.
messages: Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S.

9823:CDCA5
gene id: 9823:CDCA5
uniprot id: A0A480JPV6
uniprot id: A0A4X1V334
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9823:ACTR8
gene id: 9823:ACTR8
uniprot id: A0A286ZT42
uniprot id: A0A4X1VGN9
uniprot id: A0A8D0JQ15
uniprot id: F1SH89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9823:IL7
gene id: 9823:IL7
uniprot id: Q9N2G6
uniprot id: U5TZM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
messages: Secreted

9823:LEP
gene id: 9823:LEP
uniprot id: C7EDV4
uniprot id: Q29406
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP…
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

9823:LOC100525599
gene id: 9823:LOC100525599
uniprot id: A0A8D0UFL1
uniprot id: I3L6I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CLK2
gene id: 9823:CLK2
uniprot id: A0A4X1VZF1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:SUGP2
gene id: 9823:SUGP2
uniprot id: A0A287AX25
uniprot id: A0A4X1U3V1
names: Subcellular Location Annotation
messages: Nucleus

9823:CES3
gene id: 9823:CES3
uniprot id: A0A4X1URB8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9823:CENPU
gene id: 9823:CENPU
uniprot id: A0A4X1VRS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-U/AME1 family.
messages: Nucleus

9823:LOC100522145
gene id: 9823:LOC100522145
uniprot id: A0A8D0ZSS6
uniprot id: F1SAG6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:ALG14
gene id: 9823:ALG14
uniprot id: A0A8D1PEF8
uniprot id: F1S544
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Membrane
messages: Nucleus membrane

9823:PANX2
gene id: 9823:PANX2
uniprot id: A0A4X1UP53
uniprot id: F1RXR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9823:RAB29
gene id: 9823:RAB29
uniprot id: A0A287B978
uniprot id: A0A4X1UUZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9823:CHURC1
gene id: 9823:CHURC1
uniprot id: A0A4X1UDW4
uniprot id: F1SA59
names: Similarity
messages: Belongs to the Churchill family.

9823:ZNF768
gene id: 9823:ZNF768
uniprot id: A0A8D1B6M7
uniprot id: I3LUL2
names: Subcellular Location Annotation
messages: Nucleus

9823:SIRT5
gene id: 9823:SIRT5
uniprot id: A7XXV9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

9823:TMCO1
gene id: 9823:TMCO1
uniprot id: C5HGF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMEM147, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload. The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact.
messages: Widely expressed, with high levels in liver, kidney and heart, intermediate amounts in back fat, longissimus dorsi, brain, lymph, large intestine, small intestine and lung, and low levels in spleen and stomach.

9823:THOP1
gene id: 9823:THOP1
uniprot id: P47788
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the metabolism of neuropeptides under 20 amino acid residues long (By similarity). Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
messages: Monomer.
messages: Ubiquitous.

9823:HP
gene id: 9823:HP
uniprot id: Q8SPS7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.
messages: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
messages: Belongs to the peptidase S1 family.
messages: Expressed by the liver and secreted in plasma.
messages: Secreted
messages: Tetramer of two alpha and two beta chains; disulfide-linked (By similarity). The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers (PubMed:22922649). Interacts with CD163 (PubMed:22922649). Interacts with ERGIC3 (By similarity).
messages: The beta chain mediates most of the interactions with both subunits of hemoglobin, while the alpha chain forms the homodimeric interface.

9823:NPY
gene id: 9823:NPY
uniprot id: A0A4X1U5L6
uniprot id: H2DHJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9823:ISG20
gene id: 9823:ISG20
uniprot id: Q66UW5
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with PML and SP100 in the PML NB complex. Associates with survival motor neuron protein (SMN)-containing macromolecular nuclear complexes and U1 and U2 snRNAs and U3 snoRNA (By similarity).
messages: Belongs to the exonuclease superfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cajal body
messages: Cytoplasm
messages: Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level (By similarity).
messages: Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (By similarity).
messages: Nucleus
messages: nucleolus

9823:UTP15
gene id: 9823:UTP15
uniprot id: A0A480QFB6
uniprot id: A0A4X1SME3
names: Subcellular Location Annotation
messages: nucleolus

9823:GPR137
gene id: 9823:GPR137
uniprot id: A0A287AE66
uniprot id: A0A4X1VA00
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9823:SPTSSB
gene id: 9823:SPTSSB
uniprot id: A0A5G2RLJ3
uniprot id: A0A8D1MUI7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:PCK2
gene id: 9823:PCK2
uniprot id: A0A4X1SLW9
uniprot id: C5I4T6
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9823:CCZ1
gene id: 9823:CCZ1
uniprot id: A0A4X1TXQ7
uniprot id: I3L7N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCZ1 family.
messages: Lysosome membrane

9823:TPT1
gene id: 9823:TPT1
uniprot id: P61288
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Interacts with STEAP3.
messages: Involved in calcium binding and microtubule stabilization.

9823:KCNQ5
gene id: 9823:KCNQ5
uniprot id: A0A287BH80
uniprot id: A0A8D1CA91
uniprot id: A0A8D1CN88
uniprot id: F1RTS6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:U2AF2
gene id: 9823:U2AF2
uniprot id: A0A8D1GXD7
uniprot id: I3W8V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

9823:CLCA1
gene id: 9823:CLCA1
uniprot id: Q9TUB5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CLCR family.
messages: Expressed in ileum, trachea, and the major salivary glands. In ileum, expressed to the crypt and villus epithelia, whereas in trachea expressed in both surface epithelium and submucosal glands.
messages: Glycosylated.
messages: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Induces a cAMP-dependent chloride conductance possibly through effects on CFTR in colon carcinoma cells.
messages: The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.
messages: The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
messages: extracellular space

9823:RXFP1
gene id: 9823:RXFP1
uniprot id: A0A287BLT4
uniprot id: A0A480EUG1
uniprot id: A0A4X1U430
uniprot id: A0A4X1U4R7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:NT5DC3
gene id: 9823:NT5DC3
uniprot id: A0A4X1T5Q6
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9823:LOC100520991
gene id: 9823:LOC100520991
uniprot id: A0A4X1VJ61
uniprot id: F1RXS3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:CLDN22
gene id: 9823:CLDN22
uniprot id: A0A4X1VYQ0
uniprot id: C3VMW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:TSHB
gene id: 9823:TSHB
uniprot id: P01224
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Indispensable for the control of thyroid structure and metabolism.
messages: Secreted

9823:MTMR7
gene id: 9823:MTMR7
uniprot id: A0A480JMN9
uniprot id: A0A4X1U1N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9823:MTERF3
gene id: 9823:MTERF3
uniprot id: A0A287BLV9
uniprot id: A0A4X1U2Q6
uniprot id: A0A4X1U2R5
uniprot id: F1RY61
names: Similarity
messages: Belongs to the mTERF family.

9823:EGR2
gene id: 9823:EGR2
uniprot id: A0A8D0M3F9
uniprot id: A1XSY8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-246. May be deacetylated by HDAC6, HDAC10 or SIRT1.
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.
messages: Interacts with HCFC1 (By similarity). Interacts with WWP2 (By similarity). Interacts with UBC9 (By similarity). Interacts with CITED1 (By similarity). Interacts (via phosphorylated form) with SFN (By similarity).
messages: Nucleus
messages: Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity).
messages: Ubiquitinated by WWP2 leading to proteasomal degradation.

9823:RGR
gene id: 9823:RGR
uniprot id: A0A480E174
uniprot id: A0A4X1SDS0
names: Subcellular Location Annotation
messages: Membrane

9823:SLC52A2
gene id: 9823:SLC52A2
uniprot id: A0A4X1ULQ2
uniprot id: F1RSN6
uniprot id: Q863Y7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: (Microbial infection) In case of infection by porcine endogenous retrovirus (PERV-A), acts as a cell receptor to retroviral envelopes.
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. May also act as a receptor for 4-hydroxybutyrate.
messages: Riboflavin transport is Na(+)-independent but moderately pH-sensitive (By similarity). Activity is strongly inhibited by riboflavin analogs, such as lumiflavin (By similarity). Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) (By similarity).

9823:EP300
gene id: 9823:EP300
uniprot id: A0A480QJT4
uniprot id: A0A8D0VBW0
names: Subcellular Location Annotation
messages: Cytoplasm

9823:LMOD2
gene id: 9823:LMOD2
uniprot id: A0A8D0XUX7
uniprot id: F1SLY4
names: Subcellular Location Annotation
messages: cytoskeleton

9823:AQP6
gene id: 9823:AQP6
uniprot id: A0A4X1WDR2
uniprot id: B2MUK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:RBP4
gene id: 9823:RBP4
uniprot id: P27485
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.
messages: Produced between days 10 and 15 of pregnancy and at day 15 found in both the peri-implantation conceptus (trophectoderm and yolk sac) and the endometrial surface and glandular epithelium. Found in allantoic fluid at day 30 of gestation.
messages: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
messages: Secreted

9823:RPS6KA4
gene id: 9823:RPS6KA4
uniprot id: A0A480KP66
uniprot id: A0A480PKR2
uniprot id: A0A8D0VMQ8
uniprot id: A0A8D1EJM5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9823:LIPM
gene id: 9823:LIPM
uniprot id: A0A4X1V5I0
uniprot id: F1SCZ0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9823:PRKAA2
gene id: 9823:PRKAA2
uniprot id: C9W108
uniprot id: Q28948
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity). Interacts with DUSP29 (By similarity).
messages: Activated by phosphorylation on Thr-172. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-172. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-172. ADP also stimulates Thr-172 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-172, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol. Salicylate/aspirin directly activates kinase activity, primarily by inhibiting Thr-172 dephosphorylation (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (By similarity). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (By similarity). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negat…
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated at Thr-172 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-172 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-172, but at much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK (By similarity). Dephosphorylated by PPM1A and PPM1B at Thr-172 (mediated by STK11/LKB1) (By similarity).
messages: The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.
messages: Ubiquitinated.

9823:RTN2
gene id: 9823:RTN2
uniprot id: Q6IM67
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC100155967
gene id: 9823:LOC100155967
uniprot id: A0A8D0R3K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RAB3C
gene id: 9823:RAB3C
uniprot id: A0A287B923
uniprot id: A0A480L503
uniprot id: A0A4X1SGP0
uniprot id: A0A4X1SGP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9823:IPO8
gene id: 9823:IPO8
uniprot id: A0A4X1VLY1
uniprot id: A0A8D0N8A8
uniprot id: F1SGB6
names: Subcellular Location Annotation
messages: Cytoplasm

9823:CROT
gene id: 9823:CROT
uniprot id: A0A287B7Y5
uniprot id: A0A8D0RF96
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9823:PPP1R18
gene id: 9823:PPP1R18
uniprot id: Q767M0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with Protein phosphatase 1 (PP1).
messages: May target protein phosphatase 1 to F-actin cytoskeleton.
messages: cytoskeleton

9823:PAMR1
gene id: 9823:PAMR1
uniprot id: I3LJA3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ZDHHC6
gene id: 9823:ZDHHC6
uniprot id: A0A4X1T871
uniprot id: A0A8D1M9P0
uniprot id: F1S5J9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:CAVIN3
gene id: 9823:CAVIN3
uniprot id: A0A8D0V8J8
uniprot id: F1RMM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9823:MTCH2
gene id: 9823:MTCH2
uniprot id: A0A480WFC7
uniprot id: A0A4X1VPN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:PROP1
gene id: 9823:PROP1
uniprot id: E0A9D9
uniprot id: Q9GLL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Exclusively expressed in the developing pituitary gland.
messages: Nucleus
messages: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

9823:BCDIN3D
gene id: 9823:BCDIN3D
uniprot id: A0A287A7U6
uniprot id: A0A8D1GS15
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9823:LCK
gene id: 9823:LCK
uniprot id: B8XSK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9823:TRPC3
gene id: 9823:TRPC3
uniprot id: A0A480ZVG7
uniprot id: A0A4X1V9R6
uniprot id: C0JJ15
uniprot id: F1S1U0
names: Subcellular Location Annotation
messages: Membrane

9823:TUBD1
gene id: 9823:TUBD1
uniprot id: A0A287B840
uniprot id: A0A8D1UBM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9823:PDCL
gene id: 9823:PDCL
uniprot id: A0A286ZXX5
uniprot id: A0A8D0P5W5
names: Similarity
messages: Belongs to the phosducin family.

9823:BAK1
gene id: 9823:BAK1
uniprot id: A0A4X1T650
uniprot id: F1RZR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9823:RPN1
gene id: 9823:RPN1
uniprot id: Q9GMB0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:7737165). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with TMEM35A/NACHO (By similarity).
messages: Detected in liver (at protein level).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Melanosome
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (Probable). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity).
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9823:LGALS3
gene id: 9823:LGALS3
uniprot id: A0A8D1R0I1
uniprot id: A3EX84
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9823:CWF19L2
gene id: 9823:CWF19L2
uniprot id: B7TJ18
names: Similarity
messages: Belongs to the CWF19 family.

9823:BANF2
gene id: 9823:BANF2
uniprot id: A0A287A3L7
uniprot id: A0A4X1UV79
names: Subcellular Location Annotation
messages: Nucleus

9823:PRR5L
gene id: 9823:PRR5L
uniprot id: A0A8D1QVD9
uniprot id: F1SHG4
names: Similarity
messages: Belongs to the PROTOR family.

9823:LIAS
gene id: 9823:LIAS
uniprot id: A0A480R659
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9823:NR1I3
gene id: 9823:NR1I3
uniprot id: A0A4X1VMB0
uniprot id: Q2V0W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:HSPB6
gene id: 9823:HSPB6
uniprot id: A0A287AQR8
uniprot id: A0A4X1TIY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9823:GAP43
gene id: 9823:GAP43
uniprot id: A0A287A0Z5
uniprot id: A0A4X1T113
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9823:KEF22 p12
gene id: 9823:KEF22_p12
uniprot id: O79875
uniprot id: Q7IIC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9823:CTNND1
gene id: 9823:CTNND1
uniprot id: A0A8D1CQE3
uniprot id: A0A8D1Z1F6
uniprot id: A0A8D2BRU5
names: Similarity
messages: Belongs to the beta-catenin family.

9823:P2RY4
gene id: 9823:P2RY4
uniprot id: A0A8D1DP55
uniprot id: F1RTK8
uniprot id: Q5DKX1
uniprot id: Q5Y809
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:NPL
gene id: 9823:NPL
uniprot id: A0A481AUE8
uniprot id: Q9BEC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
messages: Cytoplasm
messages: Homotetramer.

9823:SNCA
gene id: 9823:SNCA
uniprot id: Q3I5G7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
messages: Belongs to the synuclein family.
messages: Cytoplasm
messages: Membrane
messages: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
messages: Nucleus
messages: Phosphorylated, predominantly on serine residues.
messages: Secreted
messages: Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).
messages: Synapse
messages: Ubiquitinated. The predominant conjugate is the diubiquitinated form.
messages: axon

9823:GIP
gene id: 9823:GIP
uniprot id: A0A8D0PC84
uniprot id: I3RLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

9823:METTL3
gene id: 9823:METTL3
uniprot id: A0A4X1UWD0
uniprot id: F1S8J8
names: Similarity
messages: Belongs to the MT-A70-like family.

9823:CXHXorf56
gene id: 9823:CXHXorf56
uniprot id: A0A4X1W630
uniprot id: F2Z566
names: Similarity
messages: Belongs to the STEEP1 family.

9823:SCG3
gene id: 9823:SCG3
uniprot id: A0A8D0TWD0
uniprot id: F1RYP7
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: secretory vesicle membrane

9823:HCRTR1
gene id: 9823:HCRTR1
uniprot id: O97661
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
messages: The N-terminal region is required for orexin signaling.

9823:LIN28A
gene id: 9823:LIN28A
uniprot id: A0A4X1VL35
uniprot id: B1PXG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9823:LOC100518305
gene id: 9823:LOC100518305
uniprot id: A0A8D1PTP4
names: Similarity
messages: Belongs to the apolipoprotein L family.

9823:LOC100515742
gene id: 9823:LOC100515742
uniprot id: A0A8D1XGX2
uniprot id: F1RLX2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:DPH3
gene id: 9823:DPH3
uniprot id: A0A4X1UN29
names: Similarity
messages: Belongs to the DPH3 family.

9823:ST13
gene id: 9823:ST13
uniprot id: A0A4X1VWC1
names: Similarity
messages: Belongs to the FAM10 family.

9823:LOC100520363
gene id: 9823:LOC100520363
uniprot id: F1SCC3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100524479
gene id: 9823:LOC100524479
uniprot id: A0A286ZLC6
uniprot id: A0A4X1VN36
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:NT5C2
gene id: 9823:NT5C2
uniprot id: A0A287BH12
uniprot id: A0A4X1TPW3
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9823:IRGQ
gene id: 9823:IRGQ
uniprot id: A0A8D1ZIH0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9823:GFRA1
gene id: 9823:GFRA1
uniprot id: A0A287A1Q3
uniprot id: A0A8D0QCR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9823:RALB
gene id: 9823:RALB
uniprot id: A0A4X1SFI5
uniprot id: I3LV17
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9823:LOC100513516
gene id: 9823:LOC100513516
uniprot id: A0A4X1W476
uniprot id: F1RTG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:C2H11orf68
gene id: 9823:C2H11orf68
uniprot id: A0A8D2BT85
uniprot id: F1RU27
names: Similarity
messages: Belongs to the UPF0696 family.

9823:SHC1
gene id: 9823:SHC1
uniprot id: A0A480VMH0
uniprot id: A0A5K1V5Y3
uniprot id: A0A8D1BR96
uniprot id: A0A8D1G8T8
uniprot id: A0A8D1ZGN1
uniprot id: F1RGP5
names: Subcellular Location Annotation
messages: Cytoplasm

9823:LECT2
gene id: 9823:LECT2
uniprot id: A0A4X1V4R4
uniprot id: A0A5G2QJT3
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9823:PPP6C
gene id: 9823:PPP6C
uniprot id: A0A4X1UDB4
uniprot id: F2Z5N6
names: Similarity
messages: Belongs to the PPP phosphatase family.

9823:TAS2R7
gene id: 9823:TAS2R7
uniprot id: A0A286ZVQ9
uniprot id: A0A8D0QG95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Membrane

9823:SLC16A13
gene id: 9823:SLC16A13
uniprot id: A0A4X1UZI2
uniprot id: F1RFS1
names: Subcellular Location Annotation
messages: Membrane

9823:CETN1
gene id: 9823:CETN1
uniprot id: A0A480E9F9
names: Similarity
messages: Belongs to the centrin family.

9823:HOXB5
gene id: 9823:HOXB5
uniprot id: A0A8D1K7X8
uniprot id: F1RWG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:CHCHD4
gene id: 9823:CHCHD4
uniprot id: A0A4X1U653
uniprot id: F1SPI0
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9823:ZRANB2
gene id: 9823:ZRANB2
uniprot id: A0A480LKZ8
uniprot id: Q19QU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZRANB2 family.
messages: Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection (By similarity).
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.
messages: The RanBP2-type zinc fingers mediate binding to RNA.

9823:NDP
gene id: 9823:NDP
uniprot id: A0A4X1VKU5
uniprot id: A9UHP1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:PTTG1
gene id: 9823:PTTG1
uniprot id: A0A480ZWQ5
uniprot id: A0A8D1HTD3
uniprot id: F1RR55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9823:LOC100510915
gene id: 9823:LOC100510915
uniprot id: A0A4X1UZX8
uniprot id: F1SAW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PIGL
gene id: 9823:PIGL
uniprot id: A0A4X1SRG8
uniprot id: A0A5G2RER5
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9823:IL6ST
gene id: 9823:IL6ST
uniprot id: A1EHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9823:SPARCL1
gene id: 9823:SPARCL1
uniprot id: A0A8D1YSY6
uniprot id: A0A8D2C7R4
uniprot id: A3RIE0
uniprot id: F1RW32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9823:SERPINB9
gene id: 9823:SERPINB9
uniprot id: A0A4X1SSJ0
uniprot id: A0PA01
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9823:RPA1
gene id: 9823:RPA1
uniprot id: A0A480KQ60
uniprot id: A0A8D0J1B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

9823:ADCYAP1R1
gene id: 9823:ADCYAP1R1
uniprot id: A0A8D1XES3
uniprot id: E5F1H6
names: Subcellular Location Annotation
messages: Membrane

9823:IFNB1
gene id: 9823:IFNB1
uniprot id: A0A8D0J9V5
uniprot id: Q68IQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family.
messages: Monomer.
messages: Secreted

9823:MEGF9
gene id: 9823:MEGF9
uniprot id: A0A8D1X903
uniprot id: F1SME8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DISP3
gene id: 9823:DISP3
uniprot id: A0A8D1R5X3
uniprot id: F1RF97
names: Subcellular Location Annotation
messages: Membrane

9823:TREM1
gene id: 9823:TREM1
uniprot id: Q6TYI6
uniprot id: R4SEY7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.
messages: Membrane
messages: Monomer. Homomultimer; when activated. Interacts with TYROBP/DAP12. Interacts with TLR4.

9823:LOC100158117
gene id: 9823:LOC100158117
uniprot id: A0A480TD90
uniprot id: P62802
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9823:SRSF5
gene id: 9823:SRSF5
uniprot id: A0A286ZX74
uniprot id: A0A4X1U3Z1
uniprot id: A0A8D1EE36
names: Similarity
messages: Belongs to the splicing factor SR family.

9823:SLC15A3
gene id: 9823:SLC15A3
uniprot id: A0A480MV35
uniprot id: A0A4X1VPF2
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9823:C1D
gene id: 9823:C1D
uniprot id: A0A287BKX0
uniprot id: A0A4X1WBP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9823:HSDL2
gene id: 9823:HSDL2
uniprot id: A0A4X1V4W9
names: Subcellular Location Annotation
messages: Peroxisome

9823:PAIP2
gene id: 9823:PAIP2
uniprot id: A0A4X1VBZ4
names: Similarity
messages: Belongs to the PAIP2 family.

9823:RAB4B
gene id: 9823:RAB4B
uniprot id: A0A8D0M882
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9823:LOC100523171
gene id: 9823:LOC100523171
uniprot id: A0A287BB46
uniprot id: A0A4X1V2M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ABHD3
gene id: 9823:ABHD3
uniprot id: A0A287AUZ1
uniprot id: A0A4X1VMW4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9823:PPIL2
gene id: 9823:PPIL2
uniprot id: A0A480ITS9
uniprot id: A0A8D1UL52
uniprot id: A0A8D2BB44
uniprot id: F1RL00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9823:ATG12
gene id: 9823:ATG12
uniprot id: A0A8D1TFS9
uniprot id: D7RA34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9823:GLRA1
gene id: 9823:GLRA1
uniprot id: A0A4X1TUM3
uniprot id: F1RQB7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

9823:LOC100511247
gene id: 9823:LOC100511247
uniprot id: A0A5G2RKQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LSM3
gene id: 9823:LSM3
uniprot id: A0A4X1U9H3
uniprot id: F2Z5S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9823:ART3
gene id: 9823:ART3
uniprot id: A0A5K1UHA8
uniprot id: A0A8D1KVI6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9823:CUEDC2
gene id: 9823:CUEDC2
uniprot id: A0A286ZXC4
uniprot id: A0A4X1TUY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9823:WFDC2
gene id: 9823:WFDC2
uniprot id: Q8MI69
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Broad range protease inhibitor.
messages: Detected in the distal parts of the epididymis.
messages: Homotrimer; disulfide-linked.
messages: Secreted

9823:ADRA1A
gene id: 9823:ADRA1A
uniprot id: A0A8D0THD9
uniprot id: A0A8D1I8I8
uniprot id: F6PTQ1
uniprot id: Q9TSW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9823:CD40LG
gene id: 9823:CD40LG
uniprot id: E1AXT9
uniprot id: Q95MQ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Homotrimer.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9823:TIMM13
gene id: 9823:TIMM13
uniprot id: A0A4X1VSY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9823:POLR2E
gene id: 9823:POLR2E
uniprot id: A0A4X1VTX4
uniprot id: I3LSI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

9823:AGTRAP
gene id: 9823:AGTRAP
uniprot id: A0A8D1R801
uniprot id: I3LRT0
names: Subcellular Location Annotation
messages: Membrane

9823:COPS8
gene id: 9823:COPS8
uniprot id: A0A5G2RIY7
uniprot id: A0A8D0U0L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9823:PAIP2B
gene id: 9823:PAIP2B
uniprot id: A0A4X1W8Q1
names: Similarity
messages: Belongs to the PAIP2 family.

9823:TM9SF4
gene id: 9823:TM9SF4
uniprot id: A0A287BSC9
uniprot id: A0A8D0J822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9823:ACER1
gene id: 9823:ACER1
uniprot id: A0A287BQZ5
uniprot id: A0A4X1VRI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9823:PRKAR1A
gene id: 9823:PRKAR1A
uniprot id: A0A287AKY1
uniprot id: A0A4X1SQ46
uniprot id: P07802
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
messages: Membrane
messages: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
messages: The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKACA and PRKACB (By similarity). PRKAR1A also interacts with RFC2; the complex may be involved in cell survival. Interacts with AKAP4. Interacts with RARA; the interaction occurs in the presence of cAMP or FSH and regulates RARA transcriptional activity. Interacts with the phosphorylated form of PJA2. Interacts with CBFA2T3. Interacts with PRKX; regulates this cAMP-dependent protein kinase (By similarity). Interacts with smAKAP; this interaction may target PRKAR1A to the plasma membrane. Interacts with AICDA (By similarity).
messages: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.

9823:NTF3
gene id: 9823:NTF3
uniprot id: Q06AV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9823:RFC5
gene id: 9823:RFC5
uniprot id: A0A4X1TT89
uniprot id: A0A5G2QDC8
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9823:NAPSA
gene id: 9823:NAPSA
uniprot id: A0A287AH87
uniprot id: A0A8D0IXX3
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:TET2
gene id: 9823:TET2
uniprot id: A0A8D1PR42
uniprot id: F1S116
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9823:TM4SF5
gene id: 9823:TM4SF5
uniprot id: A0A287B5K6
uniprot id: A0A4X1UXJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9823:MAL
gene id: 9823:MAL
uniprot id: A0A4X1VVL7
uniprot id: A0A5G2RFS7
names: Subcellular Location Annotation
messages: Membrane

9823:GPX2
gene id: 9823:GPX2
uniprot id: Q09HS4
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9823:RBP5
gene id: 9823:RBP5
uniprot id: A0A8D0NYA0
uniprot id: B9P3U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9823:ANKRD34C
gene id: 9823:ANKRD34C
uniprot id: A0A286ZNJ4
uniprot id: A0A8D0JD97
names: Similarity
messages: Belongs to the ANKRD34 family.

9823:VMA21
gene id: 9823:VMA21
uniprot id: A0A8D0SN17
uniprot id: A0A8D0Y3S3
uniprot id: F1S2E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9823:RHBG
gene id: 9823:RHBG
uniprot id: A0A480F489
uniprot id: Q95M75
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cytoplasmic vesicle membrane
messages: Functions as a specific ammonium transporter.
messages: Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.
messages: Membrane
messages: N-glycosylated.

9823:TWF2
gene id: 9823:TWF2
uniprot id: A0A4X1VPA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9823:SAMD8
gene id: 9823:SAMD8
uniprot id: A0A4X1SMU9
uniprot id: A0A8D0TKI3
uniprot id: A0A8D1LVY2
uniprot id: F1S2F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9823:AMIGO2
gene id: 9823:AMIGO2
uniprot id: A0A480E129
uniprot id: A0A4X1TKG4
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9823:NEK7
gene id: 9823:NEK7
uniprot id: A0A480KRK1
uniprot id: A0A4X1SPG3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:PNLIP
gene id: 9823:PNLIP
uniprot id: D4P6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9823:DDX18
gene id: 9823:DDX18
uniprot id: A0A4X1SNX3
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

9823:ID4
gene id: 9823:ID4
uniprot id: Q06AV5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with other HLH proteins.
messages: Nucleus
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).

9823:SERPINI2
gene id: 9823:SERPINI2
uniprot id: A0A4X1VEQ2
uniprot id: F1SH45
names: Similarity
messages: Belongs to the serpin family.

9823:ARVCF
gene id: 9823:ARVCF
uniprot id: A0A480JU89
uniprot id: A0A480PI53
uniprot id: A0A4X1UPB5
uniprot id: F1RHN2
names: Similarity
messages: Belongs to the beta-catenin family.

9823:SNX2
gene id: 9823:SNX2
uniprot id: A0A286ZUZ1
uniprot id: A0A8D1YH99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9823:SLC27A1
gene id: 9823:SLC27A1
uniprot id: A0A4X1UC56
uniprot id: Q3HUX0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:LIN7B
gene id: 9823:LIN7B
uniprot id: A0A480TPF2
uniprot id: A0A4X1VU10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9823:SPARC
gene id: 9823:SPARC
uniprot id: P20112
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity).
messages: Belongs to the SPARC family.
messages: basement membrane

9823:NOL12
gene id: 9823:NOL12
uniprot id: A0A4X1V662
uniprot id: I3LFR6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

9823:ELK4
gene id: 9823:ELK4
uniprot id: A0A286ZLL4
uniprot id: A0A4X1UUF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:SDAD1
gene id: 9823:SDAD1
uniprot id: A0A4X1SY54
uniprot id: F1RYU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9823:LOC100623897
gene id: 9823:LOC100623897
uniprot id: A0A4X1TV12
uniprot id: I3LVL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:F9
gene id: 9823:F9
uniprot id: A0A4X1SHD2
uniprot id: F1RQ75
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:NRDC
gene id: 9823:NRDC
uniprot id: A0A4X1WC69
uniprot id: F1S6G2
names: Similarity
messages: Belongs to the peptidase M16 family.

9823:LOC100524864
gene id: 9823:LOC100524864
uniprot id: A0A5G2QT77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SZRD1
gene id: 9823:SZRD1
uniprot id: A0A287AWQ5
uniprot id: A0A8D0M0D6
names: Similarity
messages: Belongs to the SZRD1 family.

9823:ID2
gene id: 9823:ID2
uniprot id: Q2VIU1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with GATA4 and NKX2-5 (By similarity). Interacts with NR0B2 (By similarity). Interacts with CLOCK and BMAL1 (By similarity). Interacts with IFI204 (By similarity). Interacts with NEDD9/HEF1 (By similarity).
messages: Nucleus
messages: The bHLH domain is essential for its repressor activity towards the CLOCK-BMAL1 heterodimer.
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity).

9823:PAQR9
gene id: 9823:PAQR9
uniprot id: A0A8D0Z235
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:FAM110A
gene id: 9823:FAM110A
uniprot id: A0A8D1VQT7
uniprot id: F1S865
names: Similarity
messages: Belongs to the FAM110 family.

9823:LOC100738522
gene id: 9823:LOC100738522
uniprot id: A0A287AT12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SNX5
gene id: 9823:SNX5
uniprot id: A0A4X1UZC2
uniprot id: F1SBI1
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9823:AGPAT1
gene id: 9823:AGPAT1
uniprot id: Q460L6
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9823:OGT
gene id: 9823:OGT
uniprot id: A0A4X1W241
uniprot id: K7GSL3
uniprot id: Q27HV0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, ATG4B, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (By similarity). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues. O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex. Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (By si…
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Homotrimer, oligomerizes via TPR repeats 6 and 7. Trimerization is not necessary for activity in vitro, however it increases affinity for UDP-GlcNAc (By similarity). Component of a THAP1/THAP3-HCFC1-OGT complex. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts directly with HCFC1; the interaction O-glycosylates HCFC1, regulates its proteolytic processing and transcriptional activity and, in turn, stabilizes OGT in the nucleus. Interacts (via TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase. Interacts (via TPR 5-6) with TET1, TET2 and TET3 (By similarity). Interacts (via TPR repeats 6 and 7) with ATXN10 (By similarity). Interacts with histone H2B (By similarity). Interacts with BMAL1. Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SINHCAF (By similarity). Component of a complex composed of KMT2E/MLL5, OGT and USP7; the complex stabilizes KMT2E/MLL5, preventing KMT2E/MLL5 ubiquitination and proteosomal-mediated degradation. Interacts (via TRP repeats) with KMT2E/MLL5 (via N-terminus). Interacts with USP7. Interacts with TRAK1; this interaction is not required for glycosylation of TRAK1 by this protein. Found in a complex with KIF5B, RHOT1, RHOT2 and TRAK1 (By similarity). Interacts (via TPR repeats domain) with HOXA1; the interaction takes place mainly in the nucleus (By similarity). Interacts with NSD2 (By similarity).
messages: Mitochondrion membrane
messages: Nucleus
messages: Phosphorylation on Ser-3 or Ser-4 by GSK3-beta positively regulates its activity.
messages: The TPR repeat domain is required for substrate binding and oligomerization.
messages: Ubiquitinated, leading to its proteasomal degradation.

9823:GPR1
gene id: 9823:GPR1
uniprot id: A0A4X1UXN1
uniprot id: F1SHD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9823:NPC1
gene id: 9823:NPC1
uniprot id: P56941
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A cysteine-rich N-terminal domain and a C-terminal domain containing a di-leucine motif necessary for lysosomal targeting are critical for mobilization of cholesterol from lysosomes.
messages: Belongs to the patched family.
messages: Detected in corpus luteum, granulosa cells and adrenal gland.
messages: Interacts (via the second lumenal domain) with NPC2. Interacts with TMEM97. Interacts with TIM1. Interacts with SLC38A9; this interaction inhibits cholesterol-mediated mTORC1 activation via its sterol transport activity (By similarity).
messages: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9 (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: N-glycosylated.

9823:SPO11
gene id: 9823:SPO11
uniprot id: A0A4X1UNI4
uniprot id: A0A4X1UQN6
uniprot id: A5GFN4
uniprot id: A5GFN5
names: Similarity
messages: Belongs to the TOP6A family.

9823:AHSA1
gene id: 9823:AHSA1
uniprot id: A0A4X1T4G7
uniprot id: F1SE06
names: Similarity
messages: Belongs to the AHA1 family.

9823:CYP8B1
gene id: 9823:CYP8B1
uniprot id: Q7YRB2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis (PubMed:14643796). Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (By similarity).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in fetal liver, but absent in 4 days old and 6 weeks old unweaned pigs.
messages: Microsome membrane

9823:KITLG
gene id: 9823:KITLG
uniprot id: A0A1B2TT44
uniprot id: Q29030
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form is produced by proteolytic processing of the extracellular domain.
messages: Belongs to the SCF family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation (By similarity).
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins (By similarity).
messages: Secreted
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9823:TMEM63A
gene id: 9823:TMEM63A
uniprot id: A0A286ZLG0
uniprot id: A0A8D1QMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9823:EDC3
gene id: 9823:EDC3
uniprot id: A0A4X1TMS6
uniprot id: F1SIE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9823:PPP1R3C
gene id: 9823:PPP1R3C
uniprot id: A0A4X1V0S1
uniprot id: F1SCX0
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9823:LOC100522551
gene id: 9823:LOC100522551
uniprot id: A0A8D1L275
uniprot id: F1S454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9823:ACAT2
gene id: 9823:ACAT2
uniprot id: A0A287AHQ0
uniprot id: A0A4X1VWU7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9823:SH2B2
gene id: 9823:SH2B2
uniprot id: A0A4X1UK61
uniprot id: A0A5G2QAC4
names: Similarity
messages: Belongs to the SH2B adapter family.

9823:GPR52
gene id: 9823:GPR52
uniprot id: A0A287B9P0
uniprot id: A0A4X1UD90
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:SLC16A11
gene id: 9823:SLC16A11
uniprot id: A0A4X1UZ62
uniprot id: A0A8D1I758
uniprot id: F1RFS3
names: Subcellular Location Annotation
messages: Membrane

9823:ITGB1BP2
gene id: 9823:ITGB1BP2
uniprot id: Q462R2
names: Domain
names: Function
names: Subunit
messages: Interacts with beta-1 integrin subunit. This interaction is regulated by divalent cations, and it occurs only in absence of calcium (By similarity).
messages: May play a role during maturation and/or organization of muscles cells.
messages: The tail domain binds to the cytoplasmic domain of both integrin beta-1a and beta-1d isoforms. The presence of Ca(2+) ions does not prevent binding of a fragment consisting of the second cysteine rich repeat and the tail domain but prevents the binding of the full-length protein (By similarity).

9823:MMP3
gene id: 9823:MMP3
uniprot id: C9VZX5
names: Similarity
messages: Belongs to the peptidase M10A family.

9823:LOC100511607
gene id: 9823:LOC100511607
uniprot id: F1S2Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

9823:ICAM4
gene id: 9823:ICAM4
uniprot id: A0A4X1V4Z3
uniprot id: F1S3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9823:EIF4A3
gene id: 9823:EIF4A3
uniprot id: A6M931
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Core component of the mRNA splicing-dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A. Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4. May interact with NOM1. Interacts with POLDIP3. Interacts with CWC22 and PRPF19 in an RNA-independent manner. Direct interaction with CWC22 is mediated by the helicase C-terminal domain. Full interaction with CWC22 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA. Identified in a complex composed of the EJC core, UPF3B and UPF2. The EJC core can also interact with UPF3A (in vitro). Interacts with NCBP3 (By similarity). Interacts with NRDE2 (By similarity). Interacts with DHX34; the interaction is RNA-independent (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The ATPase activity is increased some 4-fold in the presence of RNA.

9823:NEUROD4
gene id: 9823:NEUROD4
uniprot id: A0A8D0QLE1
names: Subcellular Location Annotation
messages: Nucleus

9823:TMEM184B
gene id: 9823:TMEM184B
uniprot id: A0A287A9M3
uniprot id: A0A4X1VNL2
uniprot id: A0A4X1VPT0
uniprot id: F1SKP6
names: Subcellular Location Annotation
messages: Membrane

9823:ALG10
gene id: 9823:ALG10
uniprot id: A0A4X1VY63
uniprot id: I3LNP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:GPR12
gene id: 9823:GPR12
uniprot id: A0A8D1AZ12
uniprot id: F1RTK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:TMTC4
gene id: 9823:TMTC4
uniprot id: A0A287A0I3
uniprot id: A0A4X1U7W2
uniprot id: A0A4X1UC06
uniprot id: A0A5G2QHY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9823:FGF11
gene id: 9823:FGF11
uniprot id: A0A287BK28
uniprot id: A0A4X1V2Z2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:DOK2
gene id: 9823:DOK2
uniprot id: A0A480V4P5
uniprot id: A0A8D0JZB7
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9823:CASP8
gene id: 9823:CASP8
uniprot id: A0A4X1V6R2
uniprot id: Q56VC3
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:AQP11
gene id: 9823:AQP11
uniprot id: A8WCF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Cell membrane
messages: Membrane

9823:TFPI
gene id: 9823:TFPI
uniprot id: A0A4X1TUD5
uniprot id: B5ST96
names: Subcellular Location Annotation
messages: Secreted

9823:BCAT2
gene id: 9823:BCAT2
uniprot id: A0A287BER5
uniprot id: A0A4X1W1Q7
uniprot id: A0A5G2RDA5
uniprot id: A0A8D1TR22
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9823:PANX3
gene id: 9823:PANX3
uniprot id: A0A4X1VH71
uniprot id: F1S7B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9823:FAM213A
gene id: 9823:FAM213A
uniprot id: A0A287ACV7
uniprot id: A0A4X1SGU4
uniprot id: A0A4X1SGY1
uniprot id: A0A4X1SI63
uniprot id: F1SEQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

9823:FXR2
gene id: 9823:FXR2
uniprot id: A0A8D1VVY2
names: Similarity
messages: Belongs to the FMR1 family.

9823:LOC100737876
gene id: 9823:LOC100737876
uniprot id: A0A5G2QSN2
uniprot id: A0A8D0IUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SCP2
gene id: 9823:SCP2
uniprot id: A0A4X1WCA5
uniprot id: D0G7F1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion
messages: Peroxisome

9823:STUM
gene id: 9823:STUM
uniprot id: A0A4X1TDT0
uniprot id: A0A4X1TEL7
uniprot id: A0A5G2QU55
uniprot id: I3LAT3
names: Subcellular Location Annotation
messages: Membrane

9823:TOMM22
gene id: 9823:TOMM22
uniprot id: A0A4X1VL74
uniprot id: F1SLC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9823:LY6G5C
gene id: 9823:LY6G5C
uniprot id: A0A4X1VAI9
uniprot id: K7GPH7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: Secreted

9823:KMT5B
gene id: 9823:KMT5B
uniprot id: A0A287BNJ8
uniprot id: A0A4X1SUF7
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9823:NDUFV2
gene id: 9823:NDUFV2
uniprot id: A0A287BG40
uniprot id: A0A4X1VRV3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9823:OLF42-1
gene id: 9823:OLF42-1
uniprot id: I7GH08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PAF1
gene id: 9823:PAF1
uniprot id: A0A4X1SW51
uniprot id: A0A5G2R5V9
names: Similarity
messages: Belongs to the PAF1 family.

9823:FXYD2
gene id: 9823:FXYD2
uniprot id: A0A4X1SVW2
uniprot id: A0A8D1XWJ3
uniprot id: F1SAM6
uniprot id: Q58K79
names: Similarity
messages: Belongs to the FXYD family.

9823:C2H19orf66
gene id: 9823:C2H19orf66
uniprot id: A0A8D1JJ11
uniprot id: F1S3I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Nucleus
messages: P-body

9823:VAMP4
gene id: 9823:VAMP4
uniprot id: A0A480C275
uniprot id: A0A4X1ULC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9823:TMEM201
gene id: 9823:TMEM201
uniprot id: A0A286ZM85
uniprot id: A0A4X1W8F3
uniprot id: A0A4X1W9Q6
uniprot id: F1RIH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

9823:LOC100739719
gene id: 9823:LOC100739719
uniprot id: A0A4X1U084
uniprot id: A0A5G2QQQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:PCID2
gene id: 9823:PCID2
uniprot id: A0A480KLG8
uniprot id: A0A4X1TZY0
names: Similarity
messages: Belongs to the CSN12 family.

9823:GNA13
gene id: 9823:GNA13
uniprot id: A0A287A853
uniprot id: A0A8D1KZL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9823:LOC100157239
gene id: 9823:LOC100157239
uniprot id: A0A4X1VUW5
uniprot id: A0A5G2QXK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PPP4R3A
gene id: 9823:PPP4R3A
uniprot id: A0A4X1SQV3
uniprot id: F1SD90
names: Similarity
messages: Belongs to the SMEK family.

9823:SAT2
gene id: 9823:SAT2
uniprot id: Q7PCJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur. May also catalyze acetylation of polyamines, such as norspermidine, spermidine or spermine. However, ability to acetylate polyamines is weak, suggesting that it does not act as a diamine acetyltransferase in vivo.
messages: Cytoplasm
messages: Homodimer.

9823:MED26
gene id: 9823:MED26
uniprot id: A0A4X1UTB1
uniprot id: A0A8D1XDE7
uniprot id: F1S9W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

9823:LOC100519092
gene id: 9823:LOC100519092
uniprot id: A0A287AW51
uniprot id: A0A4X1TB81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SMARCD1
gene id: 9823:SMARCD1
uniprot id: A0A4X1WCH9
names: Similarity
messages: Belongs to the SMARCD family.

9823:EBNA1BP2
gene id: 9823:EBNA1BP2
uniprot id: A0A480XE79
uniprot id: A0A8D1YDW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

9823:ATP5G2
gene id: 9823:ATP5G2
uniprot id: A0A8D0S0V7
uniprot id: I3LMW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9823:HTR2A
gene id: 9823:HTR2A
uniprot id: A0A8D1GKE2
uniprot id: P50129
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity).
messages: Interacts (via C-terminus) with MPDZ and PATJ. May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.
messages: Membrane
messages: Presynapse
messages: Synapse
messages: The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

9823:PLSCR5
gene id: 9823:PLSCR5
uniprot id: A0A4X1T309
uniprot id: F1SKD0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9823:FAM110D
gene id: 9823:FAM110D
uniprot id: A0A287BIE5
uniprot id: A0A4X1VQ29
names: Similarity
messages: Belongs to the FAM110 family.

9823:LOC100739741
gene id: 9823:LOC100739741
uniprot id: A0A0H4J4A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane
messages: Microsome membrane

9823:ASTE1
gene id: 9823:ASTE1
uniprot id: A0A8D1UPU9
uniprot id: A0A8D2BC90
names: Similarity
messages: Belongs to the asteroid family.

9823:UQCRB
gene id: 9823:UQCRB
uniprot id: A0A4X1U2M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9823:TAAR3
gene id: 9823:TAAR3
uniprot id: A0A4X1V5M6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:LOC100518442
gene id: 9823:LOC100518442
uniprot id: A0A8D0SF36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GPI
gene id: 9823:GPI
uniprot id: A0A480S836
uniprot id: P08059
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Cytoplasm
messages: Homodimer in the catalytically active form, monomer in the secreted form.
messages: ISGylated.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
messages: Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.
messages: Secreted

9823:ATF7
gene id: 9823:ATF7
uniprot id: A0A480XI33
uniprot id: A0A4X1WC38
uniprot id: A0A8D1XTI7
uniprot id: A0A8D1XZE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9823:CLSTN3
gene id: 9823:CLSTN3
uniprot id: A0A8D1GTH4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9823:SRSF2
gene id: 9823:SRSF2
uniprot id: Q06A98
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation (By similarity).
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation (By similarity).
messages: In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus). Interacts with BRDT (By similarity).
messages: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: nucleoplasm

9823:HOPX
gene id: 9823:HOPX
uniprot id: Q8MJD6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
messages: Cytoplasm
messages: Interacts with serum response factor (SRF). Component of a large complex containing histone deacetylases such as HDAC2. Interacts with the acetylated forms of HSPA1A and HSPA1B. Interacts with HSPA8.
messages: Nucleus

9823:MPC1
gene id: 9823:MPC1
uniprot id: A0A4X1VW07
uniprot id: A0A5G2REF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9823:DYRK1B
gene id: 9823:DYRK1B
uniprot id: A0A8D0MB13
uniprot id: A0A8D0S5E1
uniprot id: A0A8D0YKI5
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9823:YWHAZ
gene id: 9823:YWHAZ
uniprot id: A0A480PLY3
uniprot id: A0A4X1TV95
uniprot id: G9F6X7
names: Similarity
messages: Belongs to the 14-3-3 family.

9823:NDUFA11
gene id: 9823:NDUFA11
uniprot id: A0A4X1VRM6
uniprot id: I3LGM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:PRKG1
gene id: 9823:PRKG1
uniprot id: A0A4X1V6L9
uniprot id: Q3YJM5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9823:KCNJ15
gene id: 9823:KCNJ15
uniprot id: A0A4X1TQF6
uniprot id: F1SGV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9823:OAS1
gene id: 9823:OAS1
uniprot id: Q29599
uniprot id: Q5MX78
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
messages: Microsome
messages: Mitochondrion
messages: Monomer. Homotetramer (By similarity).
messages: Nucleus
messages: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators (By similarity).
messages: Secreted

9823:SLA-2
gene id: 9823:SLA-2
uniprot id: Q4AC39
names: Similarity
messages: Belongs to the MHC class I family.

9823:CSTF2
gene id: 9823:CSTF2
uniprot id: A0A4X1W3H3
uniprot id: A0A4X1W4R2
uniprot id: A0A4X1W611
uniprot id: F1S1L9
uniprot id: I3LE23
uniprot id: K7GS58
names: Subcellular Location Annotation
messages: Nucleus

9823:ZKSCAN1
gene id: 9823:ZKSCAN1
uniprot id: A0A480JML4
uniprot id: A0A480Z539
uniprot id: A0A8D1SBJ8
names: Subcellular Location Annotation
messages: Nucleus

9823:UBXN1
gene id: 9823:UBXN1
uniprot id: I3LUD5
names: Subcellular Location Annotation
messages: Cytoplasm

9823:PTK7
gene id: 9823:PTK7
uniprot id: A0A8D0XM67
uniprot id: F1RRN0
names: Subcellular Location Annotation
messages: Membrane

9823:SLC16A4
gene id: 9823:SLC16A4
uniprot id: A0A287AYI2
uniprot id: A0A8D0T2U1
uniprot id: A0A8D0ZSA9
uniprot id: F1S621
names: Subcellular Location Annotation
messages: Membrane

9823:MMP7
gene id: 9823:MMP7
uniprot id: F1SV71
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 calcium ions per subunit.

9823:FFAR1
gene id: 9823:FFAR1
uniprot id: A0A4X1TJT4
uniprot id: F1RM69
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:ZNF263
gene id: 9823:ZNF263
uniprot id: A0A287AS95
uniprot id: A0A4X1VTB5
uniprot id: A0A4X1VV44
uniprot id: F1RHL6
names: Subcellular Location Annotation
messages: Nucleus

9823:ZIC3
gene id: 9823:ZIC3
uniprot id: A0A5G2R7X0
uniprot id: A0A8D0MZ67
uniprot id: A0A8D0WXB9
uniprot id: F1RQ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9823:MTR
gene id: 9823:MTR
uniprot id: A0A8D1Y7H2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

9823:LBP
gene id: 9823:LBP
uniprot id: B3F714
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

9823:NDUFS5
gene id: 9823:NDUFS5
uniprot id: A0A4X1VX77
uniprot id: F1SV23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9823:RAB21
gene id: 9823:RAB21
uniprot id: A0A287A4W6
uniprot id: A0A4X1W0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: neuron projection
messages: trans-Golgi network

9823:GEMIN2
gene id: 9823:GEMIN2
uniprot id: A0A4X1SVZ2
uniprot id: F1SIQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gemin-2 family.
messages: Cytoplasm

9823:PLXNB3
gene id: 9823:PLXNB3
uniprot id: F1S2A0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:MCU
gene id: 9823:MCU
uniprot id: A0A8D1U641
uniprot id: F1SU78
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9823:CMKLR1
gene id: 9823:CMKLR1
uniprot id: B1PHQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Predominantly expressed in spleen and temperately in adipose tissue.
messages: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity).

9823:CCM2
gene id: 9823:CCM2
uniprot id: A0A287A280
uniprot id: F1ST61
names: Similarity
messages: Belongs to the CCM2 family.

9823:TEAD3
gene id: 9823:TEAD3
uniprot id: Q2VI02
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

9823:PPM1A
gene id: 9823:PPM1A
uniprot id: A0A287AJ48
uniprot id: A0A4X1WD12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9823:SLC25A15
gene id: 9823:SLC25A15
uniprot id: A0A287BBD0
uniprot id: A0A4X1SS99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:RPL14
gene id: 9823:RPL14
uniprot id: A1XQU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:LOC100522675
gene id: 9823:LOC100522675
uniprot id: A0A287AYK0
uniprot id: A0A8D1IVZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9823:LOC100512766
gene id: 9823:LOC100512766
uniprot id: A0A287B206
uniprot id: A0A8D1YKW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GTF2H4
gene id: 9823:GTF2H4
uniprot id: A0A4X1VHW7
uniprot id: Q767M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9823:KCNS3
gene id: 9823:KCNS3
uniprot id: A0A4X1U3J6
uniprot id: Q1AP76
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:FTSJ3
gene id: 9823:FTSJ3
uniprot id: A0A480PST2
uniprot id: A0A8D0HWU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

9823:HOXA2
gene id: 9823:HOXA2
uniprot id: A0A4X1TPJ8
uniprot id: F1SHT0
names: Subcellular Location Annotation
messages: Nucleus

9823:SELRC1
gene id: 9823:SELRC1
uniprot id: A0A4X1WC97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space

9823:TFAM
gene id: 9823:TFAM
uniprot id: Q5D144
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA via its HMG boxes. When bound to the mitochondrial light strand promoter, bends DNA into a U-turn shape, each HMG box bending the DNA by 90 degrees (By similarity).
messages: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
messages: Mitochondrion
messages: Monomer; binds DNA as a monomer. Homodimer. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT. In this complex TFAM recruits POLRMT to the promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Upon metabolic stress, forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT. Interacts with TFB1M and TFB2M. Interacts with CLPX; this enhances DNA-binding.
messages: Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease.
messages: mitochondrion nucleoid

9823:GADD45B
gene id: 9823:GADD45B
uniprot id: A0A4X1VS82
uniprot id: I3L775
names: Similarity
messages: Belongs to the GADD45 family.

9823:EPB42
gene id: 9823:EPB42
uniprot id: A0A4X1V764
uniprot id: F1SI48
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

9823:DUOX1
gene id: 9823:DUOX1
uniprot id: Q8HZK3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Interacts with TXNDC11, TPO and CYBA.
messages: N-glycosylated.
messages: Specifically expressed in thyroid.
messages: The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide (By similarity).

9823:BHMT
gene id: 9823:BHMT
uniprot id: A0A8D0RDE7
uniprot id: E7D6R2
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9823:SLC27A2
gene id: 9823:SLC27A2
uniprot id: A0A4X1SSA3
uniprot id: F1SQH7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:DDOST
gene id: 9823:DDOST
uniprot id: Q29381
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with SMIM22 (By similarity).
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:11443278). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).

9823:POP4
gene id: 9823:POP4
uniprot id: A0A480XEX1
uniprot id: A0A4X1TRB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9823:CLDN12
gene id: 9823:CLDN12
uniprot id: A0A8D0QIZ9
uniprot id: C3VMW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9823:PUS1
gene id: 9823:PUS1
uniprot id: A0A287B3S4
uniprot id: A0A8D0LY07
uniprot id: A0A8D0NHD1
uniprot id: F1RFR2
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9823:NTMT1
gene id: 9823:NTMT1
uniprot id: A0A4X1TKX4
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9823:LOC100517544
gene id: 9823:LOC100517544
uniprot id: A0A287A9V8
uniprot id: A0A8D0PK86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ENG
gene id: 9823:ENG
uniprot id: P37176
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer; disulfide-linked. Forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGFB1 and TGFB2 with high affinity, but not TGFB3 (PubMed:8294451). Interacts with GDF2, forming a heterotetramer with a 2:2 stoichiometry. Interacts with ACVRL1. Can form a heteromeric complex with GDF2 and ACVRL1. Interacts with BMP10. Interacts with DYNLT4. Interacts with ARRB2 (By similarity).
messages: Lacks a RGD motif, contrary to the human protein.
messages: The N-terminal OR region is composed of two intertwined domains (OR1 and OR2) with a common, novel fold. Each contains 12 beta-strands that form a parallel beta-helix-like structure, plus a single alpha-helix. The OR1 region mediates interaction with GDF2.
messages: The ZP domain mediates dimerization.
messages: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to integrins (By similarity). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8294451). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity).

9823:RPS21
gene id: 9823:RPS21
uniprot id: P63221
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9823:LOC100513450
gene id: 9823:LOC100513450
uniprot id: A0A4X1VL85
uniprot id: A0A4X1VL90
uniprot id: F1RW24
names: Similarity
messages: Belongs to the GAGE family.

9823:SMPDL3A
gene id: 9823:SMPDL3A
uniprot id: A0A8D1EWD0
uniprot id: F1S2T7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9823:GRB2
gene id: 9823:GRB2
uniprot id: A0A4X1UZ70
uniprot id: B6E241
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9823:GAD1
gene id: 9823:GAD1
uniprot id: A0A5S6GQD2
uniprot id: A0A8D1LCV8
uniprot id: P48319
names: Function
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
messages: Homodimer.

9823:ZDHHC3
gene id: 9823:ZDHHC3
uniprot id: A0A287ABA0
uniprot id: A0A480XDH8
uniprot id: A0A4X1TCB6
uniprot id: A0A8D0KAZ6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:PLEKHO1
gene id: 9823:PLEKHO1
uniprot id: A0A4X1SHE6
uniprot id: F1SS76
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:UROC1
gene id: 9823:UROC1
uniprot id: A0A480TLP6
uniprot id: A0A4X1U9M7
names: Similarity
messages: Belongs to the urocanase family.

9823:NEK9
gene id: 9823:NEK9
uniprot id: A0A480LA11
uniprot id: A0A8D0S6L4
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9823:PPP1R12C
gene id: 9823:PPP1R12C
uniprot id: A0A480QI27
uniprot id: I3LEG2
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9823:UPK1B
gene id: 9823:UPK1B
uniprot id: A0A8D1YDD5
uniprot id: Q06AT4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

9823:LOC100739365
gene id: 9823:LOC100739365
uniprot id: A0A286ZWQ9
uniprot id: A0A4X1VGR1
uniprot id: A0A8D0TZW2
names: Similarity
messages: Belongs to the NipSnap family.

9823:GNPNAT1
gene id: 9823:GNPNAT1
uniprot id: A0A287BBS9
uniprot id: A0A4X1WD60
uniprot id: A0A4X1WE54
uniprot id: F1SFE4
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9823:CAND2
gene id: 9823:CAND2
uniprot id: A0A8D0RLW3
names: Similarity
messages: Belongs to the CAND family.

9823:TFR2
gene id: 9823:TFR2
uniprot id: A0A4X1UEM7
uniprot id: F1RMX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9823:FAM136A
gene id: 9823:FAM136A
uniprot id: A0A4X1W9G6
uniprot id: F1SLD2
names: Similarity
messages: Belongs to the FAM136 family.

9823:TRIM15
gene id: 9823:TRIM15
uniprot id: Q9TSW0
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9823:TCEANC
gene id: 9823:TCEANC
uniprot id: A0A8D1CF38
uniprot id: F1SRI2
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100519643
gene id: 9823:LOC100519643
uniprot id: A0A480T5L9
uniprot id: A0A8D0V2Z5
names: Subcellular Location Annotation
messages: Membrane

9823:SNX30
gene id: 9823:SNX30
uniprot id: A0A287A447
uniprot id: A0A4X1V4I7
names: Similarity
messages: Belongs to the sorting nexin family.

9823:SEC61G
gene id: 9823:SEC61G
uniprot id: A0A287B1B1
uniprot id: A0A8D0W158
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:STX19
gene id: 9823:STX19
uniprot id: A0A4X1UR42
uniprot id: I3LSW1
names: Similarity
messages: Belongs to the syntaxin family.

9823:MAGOH
gene id: 9823:MAGOH
uniprot id: A0A4X1WAU1
uniprot id: F1S766
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9823:CLEC12A
gene id: 9823:CLEC12A
uniprot id: A0A076KXE7
uniprot id: A0A8D0YHY6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:RDH12
gene id: 9823:RDH12
uniprot id: A0A8D0RCK9
uniprot id: F1SA23
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:KYAT3
gene id: 9823:KYAT3
uniprot id: A0A287AZB0
uniprot id: A0A287BSQ5
uniprot id: A0A4X1U7A3
uniprot id: A0A4X1UCK3
names: Subunit
messages: Homodimer.

9823:UTP11
gene id: 9823:UTP11
uniprot id: A0A4X1VVM9
uniprot id: F1SV29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9823:GRK7
gene id: 9823:GRK7
uniprot id: Q8WP15
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.
messages: Autophosphorylated in vitro at Ser-490 (By similarity). Phosphorylation at Ser-36 is regulated by light and activated by cAMP.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
messages: Inhibited by phosphorylation of Ser-36.
messages: Interacts (when prenylated) with PDE6D; this promotes release from membranes.
messages: Membrane
messages: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).

9823:NLRP3
gene id: 9823:NLRP3
uniprot id: A0A8D1EM40
uniprot id: H2EW08
names: Similarity
messages: Belongs to the NLRP family.

9823:MASP1
gene id: 9823:MASP1
uniprot id: A0A4X1UGH3
uniprot id: A0A4X1UHR6
uniprot id: D5L7X3
uniprot id: D5L7X4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:PDGFRA
gene id: 9823:PDGFRA
uniprot id: A0A0G2YI07
uniprot id: A0A4X1UD13
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9823:TM2D3
gene id: 9823:TM2D3
uniprot id: A0A287BPT1
uniprot id: A0A4X1U4Q8
uniprot id: A0A4X1U956
uniprot id: F1RZ95
names: Subcellular Location Annotation
messages: Membrane

9823:AMBP
gene id: 9823:AMBP
uniprot id: A0A480P2R0
uniprot id: A0A4X1V0L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9823:DDIT4L
gene id: 9823:DDIT4L
uniprot id: A0A4X1UJ00
uniprot id: I3LT71
names: Similarity
messages: Belongs to the DDIT4 family.

9823:LOC100523537
gene id: 9823:LOC100523537
uniprot id: A0A8D1PY12
uniprot id: F1SAN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:STEAP4
gene id: 9823:STEAP4
uniprot id: D0EX57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9823:TES
gene id: 9823:TES
uniprot id: A0A480T0X9
uniprot id: Q2QLE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

9823:CALCR
gene id: 9823:CALCR
uniprot id: A0A480PVE3
uniprot id: P25117
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane
messages: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells.

9823:SGPL1
gene id: 9823:SGPL1
uniprot id: A0A287AX55
uniprot id: A0A8D0Y1S1
uniprot id: A0A8D1ZUH1
uniprot id: K9IVV1
names: Similarity
messages: Belongs to the group II decarboxylase family.

9823:PSAP
gene id: 9823:PSAP
uniprot id: A0A8D0XLK9
uniprot id: E3VVJ2
names: Subcellular Location Annotation
messages: Secreted

9823:CTNS
gene id: 9823:CTNS
uniprot id: A0A4X1UAJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9823:SEMA3F
gene id: 9823:SEMA3F
uniprot id: A0A287A3E9
uniprot id: A0A4X1SLE3
uniprot id: A0A4X1SLF6
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CLCN7
gene id: 9823:CLCN7
uniprot id: A0A5G2QUV5
uniprot id: A0A8D1AC75
uniprot id: I3LC74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9823:IL1A
gene id: 9823:IL1A
uniprot id: P18430
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated within its nuclear localization sequence, which impacts subcellular localization.
messages: Belongs to the IL-1 family.
messages: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
messages: Cytoplasm
messages: Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.
messages: Nucleus
messages: Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.
messages: Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.
messages: Secreted
messages: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

9823:FBL
gene id: 9823:FBL
uniprot id: A0A8D0RWQ5
uniprot id: I3L5T3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9823:RAB34
gene id: 9823:RAB34
uniprot id: Q06AU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Interacts with RILP.
messages: Transport protein involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes (By similarity). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity).
messages: cilium
messages: phagosome
messages: phagosome membrane

9823:XPA
gene id: 9823:XPA
uniprot id: A0A4X1U7S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9823:ERGIC3
gene id: 9823:ERGIC3
uniprot id: A0A287A0W6
uniprot id: A0A4X1T9V7
uniprot id: A0A4X1TBG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9823:CERS4
gene id: 9823:CERS4
uniprot id: A0A4X1VLT5
uniprot id: D0G774
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9823:HCAR1
gene id: 9823:HCAR1
uniprot id: A0A4X1UFK8
uniprot id: B9UM27
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:DLK2
gene id: 9823:DLK2
uniprot id: B2LW77
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Regulates adipogenesis.

9823:CLTC
gene id: 9823:CLTC
uniprot id: A0A8D1ZIN9
uniprot id: C0MHR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9823:UXT
gene id: 9823:UXT
uniprot id: A0A8D1F7J7
uniprot id: K7GT69
names: Similarity
messages: Belongs to the UXT family.

9823:AVIL
gene id: 9823:AVIL
uniprot id: A0A8D0YIU0
uniprot id: I3LI80
names: Similarity
messages: Belongs to the villin/gelsolin family.

9823:TSPAN1
gene id: 9823:TSPAN1
uniprot id: F1S3V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:CDK10
gene id: 9823:CDK10
uniprot id: B7U6F2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:ZDHHC16
gene id: 9823:ZDHHC16
uniprot id: A0A287AEX7
uniprot id: A0A287B8T5
uniprot id: A0A480VAV8
uniprot id: A0A4X1U9U9
uniprot id: A0A4X1UCB5
uniprot id: A0A8D1EJ15
uniprot id: F1S8Y3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:USP16
gene id: 9823:USP16
uniprot id: A0A287AS01
uniprot id: A0A480V986
uniprot id: A0A8D1G8U2
uniprot id: A0A8D1KP44
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9823:PTAFR
gene id: 9823:PTAFR
uniprot id: A0A287B7B1
uniprot id: A0A8D1Y0G6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9823:PTPRA
gene id: 9823:PTPRA
uniprot id: A0A287AV68
uniprot id: A0A8D1N2T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9823:EDA
gene id: 9823:EDA
uniprot id: A0A4X1VS45
uniprot id: A0A8D1HNK1
uniprot id: K7GPY3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:BEST4
gene id: 9823:BEST4
uniprot id: A0A8D1NY70
uniprot id: F1S347
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9823:MRPL43
gene id: 9823:MRPL43
uniprot id: A0A8D0I858
uniprot id: F1S8U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9823:LHX2
gene id: 9823:LHX2
uniprot id: A0A8D1WYI2
uniprot id: C4TJC6
names: Subcellular Location Annotation
messages: Nucleus

9823:SIAH1
gene id: 9823:SIAH1
uniprot id: A0A286ZUL1
uniprot id: A0A287AU84
uniprot id: A0A4X1TX37
uniprot id: A0A4X1U054
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9823:NLE1
gene id: 9823:NLE1
uniprot id: I3LTI2
names: Subcellular Location Annotation
messages: nucleolus

9823:ZER1
gene id: 9823:ZER1
uniprot id: A0A480S9H3
uniprot id: A0A4X1TQE5
uniprot id: F1RR66
names: Similarity
messages: Belongs to the zyg-11 family.

9823:MRPL13
gene id: 9823:MRPL13
uniprot id: A0A4X1T5B5
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9823:CCT3
gene id: 9823:CCT3
uniprot id: A0A287AMZ2
uniprot id: A0A4X1VT61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9823:FUT1
gene id: 9823:FUT1
uniprot id: Q29043
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity).
messages: Golgi stack membrane
messages: There are two genes (Fut1 and Fut2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner.

9823:TMEM33
gene id: 9823:TMEM33
uniprot id: A0A4X1UR13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9823:MCM3
gene id: 9823:MCM3
uniprot id: A0A4X1TI61
uniprot id: I3L7E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9823:PCNP
gene id: 9823:PCNP
uniprot id: A0A8D2CGY6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

9823:ATXN3
gene id: 9823:ATXN3
uniprot id: A0A4X1SNB2
uniprot id: A0A8D1L7I9
uniprot id: Q06AV3
names: Subcellular Location Annotation
messages: Nucleus

9823:CRTC1
gene id: 9823:CRTC1
uniprot id: A0A4X1U8A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9823:GRHL3
gene id: 9823:GRHL3
uniprot id: A0A4X1VWD6
uniprot id: F1STW0
names: Subcellular Location Annotation
messages: Nucleus

9823:OXSR1
gene id: 9823:OXSR1
uniprot id: Q863I2
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: By autophosphorylation on threonine.
messages: Cytoplasm
messages: Interacts with PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Interacts with RELL1, RELL2 and RELT. Interacts with PLSCR1 in the presence of RELT.
messages: Phosphorylates RELL1, RELL2, RELT and PAK1. Phosphorylates PLSCR1 in the presence of RELT.

9823:UBA6
gene id: 9823:UBA6
uniprot id: A0A480TN91
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9823:TSN
gene id: 9823:TSN
uniprot id: A0A286ZHZ3
uniprot id: A0A8D0QSX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9823:ILVBL
gene id: 9823:ILVBL
uniprot id: A0A480JQU4
uniprot id: A0A8D0K743
uniprot id: A0A8D1LEU1
uniprot id: F1SAN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

9823:KCNA10
gene id: 9823:KCNA10
uniprot id: A0A8D0SXT8
names: Subcellular Location Annotation
messages: Membrane

9823:TPRG1L
gene id: 9823:TPRG1L
uniprot id: A0A4X1WA34
uniprot id: A0A5G2QRM0
uniprot id: A0A8D1ICL6
uniprot id: F1RJA8
names: Similarity
messages: Belongs to the TPRG1 family.

9823:NUDT5
gene id: 9823:NUDT5
uniprot id: A0A480XE17
uniprot id: A0A4X1TFQ9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9823:CSN3
gene id: 9823:CSN3
uniprot id: P11841
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9823:KCNK7
gene id: 9823:KCNK7
uniprot id: F1RRI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:GSTM3
gene id: 9823:GSTM3
uniprot id: A0A4X1TBE8
uniprot id: F1S605
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9823:THPO
gene id: 9823:THPO
uniprot id: A0A480TRA2
uniprot id: A0A8D0RVD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9823:DDIT3
gene id: 9823:DDIT3
uniprot id: A0A4X1W673
uniprot id: B8Q504
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9823:RAB38
gene id: 9823:RAB38
uniprot id: A0A287BFW9
uniprot id: A0A4X1U326
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9823:TMEM182
gene id: 9823:TMEM182
uniprot id: A0A480L6R0
uniprot id: A0A8D1WLR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9823:RPL23A
gene id: 9823:RPL23A
uniprot id: A0A286ZL51
uniprot id: A0A4X1TPC2
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9823:SLC30A7
gene id: 9823:SLC30A7
uniprot id: A0A4X1TS57
uniprot id: B6V6V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9823:C14H12orf65
gene id: 9823:C14H12orf65
uniprot id: A0A4X1UGG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9823:OIP5
gene id: 9823:OIP5
uniprot id: A0A4X1USP8
uniprot id: A0A5G2R882
uniprot id: A0A8D1RR02
uniprot id: F1SSV3
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9823:TMED10
gene id: 9823:TMED10
uniprot id: A0A286ZV95
uniprot id: A0A4X1TBC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:MFSD5
gene id: 9823:MFSD5
uniprot id: A0A8D1VZA3
uniprot id: F1SFS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

9823:LOC100519710
gene id: 9823:LOC100519710
uniprot id: A0A4X1VVK1
uniprot id: A0A5G2QR19
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PHYHIP
gene id: 9823:PHYHIP
uniprot id: A0A4X1VG31
uniprot id: F1RMB1
names: Similarity
messages: Belongs to the PHYHIP family.

9823:PRKAA1
gene id: 9823:PRKAA1
uniprot id: A0A8D0PUW0
uniprot id: D0G7E1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9823:HSPD1
gene id: 9823:HSPD1
uniprot id: G9F6X6
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9823:ACTL6B
gene id: 9823:ACTL6B
uniprot id: A0A4X1U9V0
names: Similarity
messages: Belongs to the actin family.

9823:SLC34A2
gene id: 9823:SLC34A2
uniprot id: H2EJJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport.
messages: Membrane

9823:LOC100517101
gene id: 9823:LOC100517101
uniprot id: A0A287AX84
names: Similarity
messages: Belongs to the PRAME family.

9823:USP7
gene id: 9823:USP7
uniprot id: B6DT15
names: Similarity
messages: Belongs to the peptidase C19 family.

9823:MBOAT1
gene id: 9823:MBOAT1
uniprot id: A0A481CBJ8
uniprot id: A0A8D1GAW3
uniprot id: A0A8D1ND07
uniprot id: A0A8D1XZ22
names: Subcellular Location Annotation
messages: Membrane

9823:EIF3M
gene id: 9823:EIF3M
uniprot id: A0A4X1SV49
uniprot id: F1SGR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9823:TNR
gene id: 9823:TNR
uniprot id: A0A481CFE3
uniprot id: A0A4X1U7Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9823:ZP4
gene id: 9823:ZP4
uniprot id: Q07287
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
messages: Disulfide bonds are formed between the cysteines of three consecutive regions: Cys-368 and Cys-389, Cys-442 and Cys-447, Cys-455 and Cys-459.
messages: Expressed in oocytes.
messages: N-glycosylated; contains bi-, tri- and tetra-antennary glycans with N-acetyllactosamine repeats.
messages: O-glycosylated; contains sulfate-substituted glycans.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9823:SNX9
gene id: 9823:SNX9
uniprot id: A0A4X1VT93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9823:MYF6
gene id: 9823:MYF6
uniprot id: Q3YFL6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).
messages: Nucleus

9823:HAMP
gene id: 9823:HAMP
uniprot id: Q8MJ80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hepcidin family.
messages: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
messages: Interacts with SLC40A1; this interaction promotes SLC40A1 rapid ubiquitination.
messages: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
messages: Secreted

9823:CSGALNACT2
gene id: 9823:CSGALNACT2
uniprot id: A0A4X1U685
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9823:PARP12
gene id: 9823:PARP12
uniprot id: A0A4X1V7I7
uniprot id: F1SRP3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9823:SOX11
gene id: 9823:SOX11
uniprot id: A0A8D0S848
uniprot id: F1S9L1
names: Subcellular Location Annotation
messages: Nucleus

9823:REXO2
gene id: 9823:REXO2
uniprot id: A0A286ZIZ9
uniprot id: A0A4X1T1G5
names: Similarity
messages: Belongs to the oligoribonuclease family.

9823:SPTB
gene id: 9823:SPTB
uniprot id: A0A8D1ZJL1
names: Similarity
messages: Belongs to the spectrin family.

9823:TM9SF1
gene id: 9823:TM9SF1
uniprot id: A0A287ALE4
uniprot id: A0A4X1SP11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9823:DEFB125
gene id: 9823:DEFB125
uniprot id: A0A8D1BI38
uniprot id: Q1RLJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:NRN1L
gene id: 9823:NRN1L
uniprot id: A0A8D0ZMW8
uniprot id: I3LQE2
names: Similarity
messages: Belongs to the neuritin family.

9823:CSTF2T
gene id: 9823:CSTF2T
uniprot id: A0A4X1V914
uniprot id: F1SD01
names: Subcellular Location Annotation
messages: Nucleus

9823:PLTP
gene id: 9823:PLTP
uniprot id: Q8WMN7
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9823:LOC100736692
gene id: 9823:LOC100736692
uniprot id: A0A8D1ALX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:COQ6
gene id: 9823:COQ6
uniprot id: F1S3H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

9823:CD93
gene id: 9823:CD93
uniprot id: A0A8D1I666
uniprot id: F1SAT8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:SIGLEC1
gene id: 9823:SIGLEC1
uniprot id: A7LCJ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
messages: Cell membrane
messages: Interacts with porcine reproductive respiratory syndrome virus glycoprotein 5.
messages: Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis (By similarity). Acts as an endocytic receptor mediating clathrin dependent endocytosis. In case of porcine reproductive and respiratory syndrome virus (PRRSV), mediates virion attachment and internalization into alveolar macrophages through a clathrin-coated dependent process.
messages: The sialic acid-binding domain is essential for efficient PRRSV virus attachment and internalization to alveolar macrophages.

9823:SPDL1
gene id: 9823:SPDL1
uniprot id: A0A4X1U4Y5
uniprot id: I3LS43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9823:LOC100625111
gene id: 9823:LOC100625111
uniprot id: A0A8D1M792
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MET
gene id: 9823:MET
uniprot id: Q2QLE0
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Membrane
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9823:LOC100517422
gene id: 9823:LOC100517422
uniprot id: A0A4X1T7R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CTSL
gene id: 9823:CTSL
uniprot id: A0A480QKK7
uniprot id: A0A4X1V401
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9823:S1PR5
gene id: 9823:S1PR5
uniprot id: Q684M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins (By similarity).

9823:PGAM2
gene id: 9823:PGAM2
uniprot id: A0A8D0QR32
uniprot id: B5KJG2
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9823:GLCE
gene id: 9823:GLCE
uniprot id: A0A4X1T674
uniprot id: F1SIU0
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9823:SLC33A1
gene id: 9823:SLC33A1
uniprot id: A0A4X1SNA5
uniprot id: I3LE25
names: Subcellular Location Annotation
messages: Membrane

9823:TMEM255B
gene id: 9823:TMEM255B
uniprot id: A0A287B0T4
uniprot id: A0A8D0VFW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9823:WHAMM
gene id: 9823:WHAMM
uniprot id: A0A8D1BHR7
uniprot id: F1RI99
names: Subcellular Location Annotation
messages: Membrane

9823:SPC25
gene id: 9823:SPC25
uniprot id: A0A480PW82
uniprot id: A0A8D0VQ74
uniprot id: A0A8D1G7R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9823:OVGP1
gene id: 9823:OVGP1
uniprot id: Q28990
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.
messages: Oviduct.
messages: secretory vesicle

9823:SEC31B
gene id: 9823:SEC31B
uniprot id: A0A8D1HFE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

9823:DSG2
gene id: 9823:DSG2
uniprot id: A0A8D1PSM6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9823:LOC100511184
gene id: 9823:LOC100511184
uniprot id: A0A4X1V1Z1
uniprot id: F1S9Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TDRD7
gene id: 9823:TDRD7
uniprot id: A0A480HIF7
uniprot id: A0A8D1KED1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

9823:DXO
gene id: 9823:DXO
uniprot id: A0A4X1VBG9
uniprot id: A5PEZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9823:CUTA
gene id: 9823:CUTA
uniprot id: A0A4X1TB30
uniprot id: F1RZR6
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9823:MRPS18B
gene id: 9823:MRPS18B
uniprot id: L0GCT6
uniprot id: Q767K8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

9823:LOC100153915
gene id: 9823:LOC100153915
uniprot id: A0A287AI92
uniprot id: A0A4X1UEM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9823:SLC1A1
gene id: 9823:SLC1A1
uniprot id: A0A4X1W8W1
uniprot id: F1SK41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9823:OSGEP
gene id: 9823:OSGEP
uniprot id: A0A8D0J405
uniprot id: F1S8H4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Cytoplasm
messages: Nucleus

9823:ADM
gene id: 9823:ADM
uniprot id: P53366
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: AM and PAMP are potent hypotensive and vasodilatator agents.
messages: Belongs to the adrenomedullin family.
messages: Highly expressed in adrenal glands, lung and kidney.
messages: Secreted

9823:LOC100623890
gene id: 9823:LOC100623890
uniprot id: A0A8D0RL81
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GPAT4
gene id: 9823:GPAT4
uniprot id: A0A4X1U7M4
uniprot id: B8XTR4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:SLC39A1
gene id: 9823:SLC39A1
uniprot id: A0A8D0IDA8
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100626785
gene id: 9823:LOC100626785
uniprot id: A0ZQ09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ARPC2
gene id: 9823:ARPC2
uniprot id: A0A4X1UM70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9823:FUZ
gene id: 9823:FUZ
uniprot id: A0A4X1VWL1
uniprot id: F1RH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

9823:NAXD
gene id: 9823:NAXD
uniprot id: A0A480VIL3
uniprot id: A0A4X1U1Z0
uniprot id: A0A4X1U774
uniprot id: I3LS60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Mitochondrion

9823:LOC100621476
gene id: 9823:LOC100621476
uniprot id: A0A8D1D5D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9823:HAGHL
gene id: 9823:HAGHL
uniprot id: A0A481DA93
uniprot id: A0A8D1QI56
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9823:ATP8B2
gene id: 9823:ATP8B2
uniprot id: A0A480UHV2
uniprot id: A0A4X1W0F3
uniprot id: A0A8D0RFE3
uniprot id: I3LIK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9823:MRPS9
gene id: 9823:MRPS9
uniprot id: A0A4X1W0D2
uniprot id: I3LU08
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9823:SNAPC3
gene id: 9823:SNAPC3
uniprot id: A0A4X1W5S0
uniprot id: F2Z5Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

9823:PSMC3IP
gene id: 9823:PSMC3IP
uniprot id: A0A4X1U064
uniprot id: F1S1D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9823:NR0B1
gene id: 9823:NR0B1
uniprot id: P79386
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (By similarity). Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (By similarity).
messages: Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal LXXLL motifs (By similarity).
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).

9823:ATP1A2
gene id: 9823:ATP1A2
uniprot id: D2WKD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1.
messages: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity).

9823:MAP1LC3A
gene id: 9823:MAP1LC3A
uniprot id: A0A8D1YWJ5
uniprot id: D2KQR0
names: Similarity
messages: Belongs to the ATG8 family.

9823:LOC106504546
gene id: 9823:LOC106504546
uniprot id: A0A8D0PIK8
names: Similarity
messages: Belongs to the serpin family.

9823:TNXB
gene id: 9823:TNXB
uniprot id: A5A8W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9823:SLC7A9
gene id: 9823:SLC7A9
uniprot id: A8HG47
names: Subcellular Location Annotation
messages: Membrane

9823:FZD4
gene id: 9823:FZD4
uniprot id: A0A480XCK5
uniprot id: A0A4X1U400
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9823:LOC100513271
gene id: 9823:LOC100513271
uniprot id: A0A4X1V0B6
uniprot id: F1S9Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ACVR1
gene id: 9823:ACVR1
uniprot id: A0A4X1VK14
uniprot id: E9M2M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9823:MEP1B
gene id: 9823:MEP1B
uniprot id: A0A8D1C3S6
uniprot id: F1SAL4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:TADA1
gene id: 9823:TADA1
uniprot id: A0A4X1VF42
uniprot id: F1S248
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9823:LOC100049687
gene id: 9823:LOC100049687
uniprot id: A5HJZ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:NAF1
gene id: 9823:NAF1
uniprot id: A0A5G2QM69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

9823:OGFRL1
gene id: 9823:OGFRL1
uniprot id: A0A287BRA0
uniprot id: A0A8D1DQ82
uniprot id: A0A8D1Z5P8
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

9823:ITGAV
gene id: 9823:ITGAV
uniprot id: A0A4X1TWU5
uniprot id: A2RQD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9823:SHTN1
gene id: 9823:SHTN1
uniprot id: A0A4X1SXE7
uniprot id: A0A4X1SZG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9823:SRY
gene id: 9823:SRY
uniprot id: P36393
uniprot id: Q5I925
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SRY family.
messages: Cytoplasm
messages: Expressed in male pig embryo between 21 dpc and 26 dpc. Not detected in 31 dpc embryos.
messages: Expressed in the genital ridge.
messages: Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its DNA-binding activity. The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form. Interaction with PARP1 impaired its DNA-binding activity.
messages: Nucleus
messages: Nucleus speckle
messages: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
messages: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.

9823:SDHB
gene id: 9823:SDHB
uniprot id: Q007T0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (PubMed:15989954). Interacts with SDHAF1; the interaction is required for iron-sulfur cluster incorporation into SDHB (By similarity).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9823:AMOTL1
gene id: 9823:AMOTL1
uniprot id: A0A8D0ZEM4
uniprot id: A0A8D0ZL27
uniprot id: A0A8D1CSA2
uniprot id: A0A8D1Z2P4
uniprot id: A0A8D1Z2R7
names: Similarity
messages: Belongs to the angiomotin family.

9823:FAM131C
gene id: 9823:FAM131C
uniprot id: A0A287BPY6
uniprot id: A0A8D0UGQ3
names: Similarity
messages: Belongs to the FAM131 family.

9823:UNC45B
gene id: 9823:UNC45B
uniprot id: A9X3M3
names: Subcellular Location Annotation
messages: A band
messages: Z line
messages: perinuclear region

9823:RIPOR2
gene id: 9823:RIPOR2
uniprot id: A0A286ZIL0
uniprot id: A0A286ZJE0
uniprot id: A0A4X1VMC2
uniprot id: A0A4X1VMC9
uniprot id: A0A4X1VMD4
uniprot id: A0A4X1VNK6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: stereocilium membrane

9823:KLRK1
gene id: 9823:KLRK1
uniprot id: A0A286ZSM5
uniprot id: A0A4X1UZL1
uniprot id: Q9GLF5
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Detected in peripheral blood leukocytes, macrophages, monocytes and natural killer cells.
messages: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins (By similarity).
messages: Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Can form disulfide-bonded heterodimer with CD94 (By similarity). Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (By similarity).
messages: Is not capable of signal transduction by itself, but operates through the adapter protein HCST.
messages: Membrane

9823:PIAS4
gene id: 9823:PIAS4
uniprot id: A0A4X1VM99
uniprot id: I3LNY9
names: Similarity
messages: Belongs to the PIAS family.

9823:ELF5
gene id: 9823:ELF5
uniprot id: A0A8D1C4L1
uniprot id: F1SGT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:ESRRB
gene id: 9823:ESRRB
uniprot id: A0A287AYZ8
uniprot id: A0A4X1T800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9823:LOC100516302
gene id: 9823:LOC100516302
uniprot id: A0A4X1V144
uniprot id: I3LTB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9823:CCDC181
gene id: 9823:CCDC181
uniprot id: A0A287AG09
uniprot id: A0A287AT44
uniprot id: A0A4X1UZ97
uniprot id: A0A4X1V0I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

9823:LOC100515529
gene id: 9823:LOC100515529
uniprot id: F1S6N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SFTPA1
gene id: 9823:SFTPA1
uniprot id: P49874
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPA family.
messages: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
messages: Oligomeric complex of 6 set of homotrimers.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: Secreted
messages: extracellular matrix
messages: surface film

9823:LOC100518060
gene id: 9823:LOC100518060
uniprot id: A0A4X1SXR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100623796
gene id: 9823:LOC100623796
uniprot id: A0A8D0ZQG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GLYR1
gene id: 9823:GLYR1
uniprot id: A0A4X1VTD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

9823:C8B
gene id: 9823:C8B
uniprot id: A0SEH2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9823:SLC4A1
gene id: 9823:SLC4A1
uniprot id: A0A8D1HL68
uniprot id: K7GR72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9823:FOXI1
gene id: 9823:FOXI1
uniprot id: A0A8D0SVM4
uniprot id: F1RR95
names: Subcellular Location Annotation
messages: Nucleus

9823:POLH
gene id: 9823:POLH
uniprot id: A0A8D1JRJ5
names: Subcellular Location Annotation
messages: Nucleus

9823:MRPS21
gene id: 9823:MRPS21
uniprot id: A0A286ZNB3
uniprot id: A0A4X1SGN7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9823:ARL1
gene id: 9823:ARL1
uniprot id: A0A4X1T0K7
uniprot id: Q52NJ5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9823:B4GAT1
gene id: 9823:B4GAT1
uniprot id: V9LLL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:RP2
gene id: 9823:RP2
uniprot id: A0A480E0X6
uniprot id: A0A4X1VJZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9823:SGTA
gene id: 9823:SGTA
uniprot id: A0A287A1V6
uniprot id: A0A4X1VS62
names: Similarity
messages: Belongs to the SGT family.

9823:SST
gene id: 9823:SST
uniprot id: P01168
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the somatostatin family.
messages: C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.
messages: Expressed in the pancreas and the spleen (at protein level).
messages: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.
messages: May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity).
messages: Secreted

9823:BRF2
gene id: 9823:BRF2
uniprot id: A0A287AVZ6
uniprot id: A0A8D0Y1N6
names: Similarity
messages: Belongs to the TFIIB family.

9823:BEX5
gene id: 9823:BEX5
uniprot id: A0A4X1W532
uniprot id: F1RYG4
names: Similarity
messages: Belongs to the BEX family.

9823:MXRA8
gene id: 9823:MXRA8
uniprot id: A0A287AKH1
uniprot id: A0A8D0VQP7
uniprot id: A0A8D1DAQ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:F8
gene id: 9823:F8
uniprot id: P12263
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
messages: Interacts with vWF. vWF binding is essential for the stabilization of F8 in circulation (By similarity).
messages: Proteolytically cleaved by cathepsin CTSG to produce a partially activated form.
messages: extracellular space

9823:NCAPG
gene id: 9823:NCAPG
uniprot id: A0A480VBP6
uniprot id: A0A4X1VBG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9823:CHD8
gene id: 9823:CHD8
uniprot id: A0A481CXW3
uniprot id: A0A4X1UY74
uniprot id: A0A5K1U8D0
uniprot id: A0A8D0IS76
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

9823:IP6K1
gene id: 9823:IP6K1
uniprot id: A0A4X1SQJ4
uniprot id: A0A8D0Q0F6
uniprot id: F1SPR3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9823:EFHC1
gene id: 9823:EFHC1
uniprot id: A0A287B0G0
uniprot id: A0A480I608
uniprot id: A0A8D2A5J1
names: Subcellular Location Annotation
messages: cilium axoneme

9823:ATXN1L
gene id: 9823:ATXN1L
uniprot id: A0A8D0UDN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9823:ADAMTS10
gene id: 9823:ADAMTS10
uniprot id: A0A8D1IEZ8
uniprot id: F8UV45
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:L3MBTL2
gene id: 9823:L3MBTL2
uniprot id: A0A480PDF4
uniprot id: A0A480PHL8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9823:LOC100627283
gene id: 9823:LOC100627283
uniprot id: A0A4X1W240
uniprot id: I3LQU4
names: Subcellular Location Annotation
messages: Nucleus

9823:DYNC2LI1
gene id: 9823:DYNC2LI1
uniprot id: A0A480JTX3
uniprot id: A0A4X1SKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9823:SMYD2
gene id: 9823:SMYD2
uniprot id: C3RZA1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: During fetal muscle development, expression increases from 33 to 90 dpc.
messages: Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1. Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1 (By similarity).
messages: Nucleus
messages: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
messages: cytosol

9823:ELAVL1
gene id: 9823:ELAVL1
uniprot id: A0A4X1VIC6
uniprot id: D3K5N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm

9823:MCM2
gene id: 9823:MCM2
uniprot id: A0A4X1TY86
uniprot id: F1SPF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9823:DCP2
gene id: 9823:DCP2
uniprot id: A0A286ZYW5
uniprot id: A0A4X1U2G7
uniprot id: A0A5G2R5Y7
uniprot id: A0A8D1FT55
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9823:TMEM54
gene id: 9823:TMEM54
uniprot id: A0A286ZLI1
uniprot id: A0A8D0K925
uniprot id: A0A8D2BMV6
uniprot id: I3LA99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9823:NAXE
gene id: 9823:NAXE
uniprot id: Q0PIT9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity).
messages: Homodimer (By similarity). Interacts with APOA1 and APOA2 (By similarity).
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

9823:DUSP5
gene id: 9823:DUSP5
uniprot id: A0A287B2F2
uniprot id: A0A4X1TFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9823:BZW1
gene id: 9823:BZW1
uniprot id: A0A4X1VBP9
uniprot id: K9IVQ0
names: Similarity
messages: Belongs to the BZW family.

9823:ANAPC13
gene id: 9823:ANAPC13
uniprot id: A0A4X1TRG5
uniprot id: D4NZI4
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9823:RPA2
gene id: 9823:RPA2
uniprot id: A0A4X1U0L4
uniprot id: A0A5G2RFY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 2 family.
messages: Nucleus

9823:PTGES2
gene id: 9823:PTGES2
uniprot id: A0A8D1K232
uniprot id: F1RRY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

9823:TNFSF15
gene id: 9823:TNFSF15
uniprot id: A0A4X1UVV2
uniprot id: I3LL00
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:SERPINF1
gene id: 9823:SERPINF1
uniprot id: A0A4X1U9I7
uniprot id: Q0PM28
names: Similarity
messages: Belongs to the serpin family.

9823:B3GALNT1
gene id: 9823:B3GALNT1
uniprot id: A0A481AY33
uniprot id: Q864U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development.

9823:LOC100621347
gene id: 9823:LOC100621347
uniprot id: A0A4X1TFW9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9823:MAP1LC3C
gene id: 9823:MAP1LC3C
uniprot id: A0A287ABF3
uniprot id: A0A8D0IGJ6
names: Similarity
messages: Belongs to the ATG8 family.

9823:LOC100622735
gene id: 9823:LOC100622735
uniprot id: A0A4X1TXB0
uniprot id: A0A5G2RK81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SGK1
gene id: 9823:SGK1
uniprot id: A0A286ZMR5
uniprot id: A0A286ZRM8
uniprot id: A0A4X1VG12
uniprot id: A0A8D1L2C2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:PRKN
gene id: 9823:PRKN
uniprot id: Q1WDP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. Parkin subfamily.
messages: Forms an E3 ubiquitin ligase complex.
messages: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
messages: Mitochondrion
messages: cytosol

9823:GATB
gene id: 9823:GATB
uniprot id: A0A480U7I0
uniprot id: A0A4X1SMX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9823:BAG6
gene id: 9823:BAG6
uniprot id: A5D9M6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides an…
messages: Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol. Interacts with UBL4A; the interaction is direct and required for UBL4A protein stability. Interacts with AIFM1. Interacts with HSPA2. Interacts with CTCFL. Interacts with p300/EP300. Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation. Interacts with ricin A chain. Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex. Interacts with SYVN1. Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination. Interacts with ZFAND2B. Interacts with KPNA2. Interacts with UBQLN4 (By similarity).
messages: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2).
messages: May mediate ricin-induced apoptosis.
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: Ricin can induce a cleavage by the caspase CASP3. The released C-terminal peptide induces apoptosis.
messages: The ubiquitin-like domain mediates interaction with the E3 ubiquitin-protein ligase RNF126 which is responsible for the BAG6-dependent ubiquitination of client proteins. SGTA also binds this domain and competes with RNF126 to antagonize client protein ubiquitination and degradation. The ubiquitin-like domain also mediates the interaction with USP13.
messages: cytosol
messages: extracellular exosome

9823:KCNN4
gene id: 9823:KCNN4
uniprot id: A0A4X1W3A5
uniprot id: Q8WMG4
names: Subcellular Location Annotation
messages: Membrane

9823:PI4K2A
gene id: 9823:PI4K2A
uniprot id: A0A4X1U7Y0
uniprot id: F1S8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9823:ARPC1B
gene id: 9823:ARPC1B
uniprot id: A0A4X1U5P2
uniprot id: B5APU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9823:LOC106507313
gene id: 9823:LOC106507313
uniprot id: A0A287B7N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:HAPLN2
gene id: 9823:HAPLN2
uniprot id: A0A4X1VXX6
uniprot id: F1RP37
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:ACOT13
gene id: 9823:ACOT13
uniprot id: A0A8D0RI54
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9823:RAB4A
gene id: 9823:RAB4A
uniprot id: A0A287AKG6
uniprot id: A0A4X1U7Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9823:TMEM237
gene id: 9823:TMEM237
uniprot id: A0A4X1V674
uniprot id: A0A8D1N3E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9823:ALAS2
gene id: 9823:ALAS2
uniprot id: A0A481BET8
uniprot id: A0A4X1VBZ1
uniprot id: A0A4X1VC48
uniprot id: A0A8D0PNK7
uniprot id: F1RUD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9823:SLC35A1
gene id: 9823:SLC35A1
uniprot id: F1S0G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9823:PSIP1
gene id: 9823:PSIP1
uniprot id: A0A287BE52
uniprot id: A0A4X1W5S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9823:TAS1R2
gene id: 9823:TAS1R2
uniprot id: I1ZBR6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SPINK4
gene id: 9823:SPINK4
uniprot id: P37109
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Inhibits the glucose-induced insulin secretion from perfused pancreas; also plays a role in the immune system. Does not inhibit trypsin.
messages: Secreted
messages: Synthesized in duodenal goblet cells and in monocytes in bone marrow and blood.

9823:DYDC2
gene id: 9823:DYDC2
uniprot id: A0A4X1SHP8
uniprot id: F1SEQ8
names: Similarity
messages: Belongs to the dpy-30 family.

9823:FAM160B1
gene id: 9823:FAM160B1
uniprot id: A0A8D0QCY5
uniprot id: F1S4V3
names: Similarity
messages: Belongs to the FHIP family.

9823:SDHAF2
gene id: 9823:SDHAF2
uniprot id: A0A8D0XRJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9823:KCNV2
gene id: 9823:KCNV2
uniprot id: A0A4X1W8Q8
names: Subcellular Location Annotation
messages: Membrane

9823:CKM
gene id: 9823:CKM
uniprot id: Q5XLD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
messages: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

9823:LOC100623804
gene id: 9823:LOC100623804
uniprot id: A0A4X1U072
uniprot id: A0A5G2QXJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:POLR2I
gene id: 9823:POLR2I
uniprot id: A0A480LGI2
uniprot id: P60899
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).
messages: nucleolus

9823:HYAL4
gene id: 9823:HYAL4
uniprot id: A0A4X1VWR1
uniprot id: F1SMK4
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9823:BCL2A1
gene id: 9823:BCL2A1
uniprot id: A0A4X1UQW5
uniprot id: C7F841
names: Similarity
messages: Belongs to the Bcl-2 family.

9823:CASP2
gene id: 9823:CASP2
uniprot id: A0A480L4F2
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:LOC100524142
gene id: 9823:LOC100524142
uniprot id: A0A4X1W9N3
uniprot id: A0A5G2QUI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ENO4
gene id: 9823:ENO4
uniprot id: A0A481BB88
uniprot id: A0A4X1SZI5
uniprot id: F1S4S3
names: Similarity
messages: Belongs to the enolase family.

9823:DUSP10
gene id: 9823:DUSP10
uniprot id: A0A4X1TKZ2
uniprot id: F1S9I4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9823:LNPK
gene id: 9823:LNPK
uniprot id: A0A287BL28
uniprot id: A0A8D0RC79
uniprot id: A0A8D1I247
uniprot id: A0A8D1XLW7
uniprot id: I3LG37
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9823:POLR2F
gene id: 9823:POLR2F
uniprot id: A0A4X1VEK9
uniprot id: F1SKN8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9823:NKX2-3
gene id: 9823:NKX2-3
uniprot id: A0A4X1U6N2
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100739156
gene id: 9823:LOC100739156
uniprot id: A0A4X1VH67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SERINC2
gene id: 9823:SERINC2
uniprot id: A0A480TQ97
uniprot id: A0A8D1VLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9823:OBP2B
gene id: 9823:OBP2B
uniprot id: P53715
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket (By similarity).
messages: Predominantly monomer (By similarity). May form homodimer (By similarity). Interacts with LMBR1L; this interaction mediates the endocytosis of LCN1 (By similarity).
messages: Secreted

9823:SNX32
gene id: 9823:SNX32
uniprot id: A0A287AWP2
uniprot id: A0A8D0PJP3
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9823:HMGB1
gene id: 9823:HMGB1
uniprot id: A0A4X1TJK2
uniprot id: P12682
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion. Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity.
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Endosome
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.
messages: HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4. However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance.
messages: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity).
messages: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization. Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM. Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways (PubMed:14660645). Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex. Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin imm…
messages: In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).
messages: Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by glycyrrhizin. Associates with the TLR4:LY96 receptor complex. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with KPNA1; involved in nuclear import. Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT. Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53. Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response. Interacts with XPO1; mediating nuclear export.
messages: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins (By similarity).
messages: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding. Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity).
messages: Nucleus
messages: Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion.
messages: Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS.
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).
messages: Secreted
messages: The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins.

9823:LOC100523626
gene id: 9823:LOC100523626
uniprot id: A0A4X1SNG8
uniprot id: F1RLW5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:EIF1AD
gene id: 9823:EIF1AD
uniprot id: A0A4X1UDV5
uniprot id: F1RU32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9823:ACAP3
gene id: 9823:ACAP3
uniprot id: A0A4X1W8Z5
uniprot id: F1RJG0
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9823:CRBN
gene id: 9823:CRBN
uniprot id: A0A287BAH3
uniprot id: A0A4X1V0S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9823:BSX
gene id: 9823:BSX
uniprot id: A0A4X1VIV4
uniprot id: F1S9Q4
names: Subcellular Location Annotation
messages: Nucleus

9823:MC1R
gene id: 9823:MC1R
uniprot id: Q95MM8
uniprot id: Q9TU05
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH (By similarity). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:9799269).
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Variation is correlated with coat color. MC1R*2 is associated with the black color of European large black and Chinese meishan pigs. MC1R*3 is associated with the black color in the hampshire breed. MC1R*4 is found in recessive red animals.

9823:ATP5B
gene id: 9823:ATP5B
uniprot id: A0A480JUN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9823:KIF24
gene id: 9823:KIF24
uniprot id: A0A4X1UR16
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:MANF
gene id: 9823:MANF
uniprot id: E0YLM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9823:TRPC7
gene id: 9823:TRPC7
uniprot id: C0JJ18
names: Subcellular Location Annotation
messages: Membrane

9823:VWDE
gene id: 9823:VWDE
uniprot id: A0A5G2QX75
uniprot id: A0A5G2RNP4
uniprot id: A0A8D0RFV9
uniprot id: A0A8D0RQH1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100737060
gene id: 9823:LOC100737060
uniprot id: F1SLP8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:WARS2
gene id: 9823:WARS2
uniprot id: A0A8D1V9D8
uniprot id: B2ZF50
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9823:SSTR3
gene id: 9823:SSTR3
uniprot id: A0A4X1ULT4
uniprot id: A0A8D0PP89
uniprot id: I3LL93
uniprot id: Q6YEX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:LOC100623990
gene id: 9823:LOC100623990
uniprot id: A0A8D1CUR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:DNMT3A
gene id: 9823:DNMT3A
uniprot id: A1XX82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9823:PPP1R9B
gene id: 9823:PPP1R9B
uniprot id: A0A480L9H7
uniprot id: A0A8D1IPX5
names: Subcellular Location Annotation
messages: cytoskeleton

9823:STAT3
gene id: 9823:STAT3
uniprot id: E7CR02
uniprot id: Q19S50
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated.
messages: Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, CNTF, LIF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Tyrosine phosphorylated upon stimulation with EGF. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Phosphorylated on Ser-727 by RPS6KA5 (By similarity). Phosphorylation at Tyr-705 by FER, isoform M2 of PKM (PKM2) or PTK6 leads to an increase of its transcriptional activity (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling (By similarity).
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Detected in lung, heart, oviduct, ovary, uterus and kidney (at protein level). Detected in ovary, oviduct, and at lower levels in uterus and lung.
messages: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1 (By similarity). Interacts with IL23R in presence of IL23 (By similarity). Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2 (By similarity). Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with ZIPK/DAPK3. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with PRKCE and promotes DNA binding activity of STAT3 (By similarity). Interacts with STMN3, antagonizing its microtubule-destabilizing activity (By similarity). Interacts with the 'Lys-129' acetylated form of BIRC5/survivin. Interacts with FER. Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain). Interacts with INPP5F; the interaction is independent of STAT3 Tyr-705 phosphorylation status. Interacts with FGFR4 (By similarity). Interacts with OCAD1 (By similarity). Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB1 (By similarity). Interacts and may form heterodimers with NHLH1 (By similarity).
messages: Involved in the gp130-mediated signaling pathway.
messages: Nucleus
messages: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation (By similarity). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
messages: Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated.

9823:NDRG2
gene id: 9823:NDRG2
uniprot id: A0A4X1UYJ4
uniprot id: Q001C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

9823:MMP16
gene id: 9823:MMP16
uniprot id: A0A287AKC1
uniprot id: A0A4X1UEF0
names: Similarity
messages: Belongs to the peptidase M10A family.

9823:CDCA7L
gene id: 9823:CDCA7L
uniprot id: A0A4X1T6W4
uniprot id: A0A8D1IWN3
uniprot id: F1SC06
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:CLEC12B
gene id: 9823:CLEC12B
uniprot id: A0A088FWR4
uniprot id: A0A8D1SNW2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:LOC100521605
gene id: 9823:LOC100521605
uniprot id: A0A5G2QF83
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MYH7B
gene id: 9823:MYH7B
uniprot id: A0A287B9S1
uniprot id: A0A4X1T8T2
uniprot id: F1S4X7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: myofibril

9823:CENPI
gene id: 9823:CENPI
uniprot id: A0A4X1W642
uniprot id: F1S1L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

9823:APEX1
gene id: 9823:APEX1
uniprot id: A0A8D0YHX9
uniprot id: B6VAP9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9823:ICAM3
gene id: 9823:ICAM3
uniprot id: C0JX97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9823:LOC100623351
gene id: 9823:LOC100623351
uniprot id: A0A287AFW5
uniprot id: A0A4X1TBL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9823:IMPAD1
gene id: 9823:IMPAD1
uniprot id: A0A480TJZ2
uniprot id: F1RT67
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily.
messages: Contains N-linked glycan resistant to endoglycosydase H.
messages: Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.
messages: Golgi apparatus
messages: Strongly inhibited by lithium.
messages: trans-Golgi network membrane

9823:CCNH
gene id: 9823:CCNH
uniprot id: A0A480Q032
uniprot id: A0A4X1TCE5
uniprot id: A0A8D1EU90
uniprot id: C9K506
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9823:NME2
gene id: 9823:NME2
uniprot id: Q2EN76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6) (By similarity). Interacts with CAPN8 (By similarity). Interacts with AKAP13 (By similarity). Interacts ITGB1BP1 (via C-terminal domain region) (By similarity). Interacts with BCL2L10 (By similarity).
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity (By similarity).
messages: Nucleus
messages: lamellipodium
messages: ruffle

9823:RHBDL2
gene id: 9823:RHBDL2
uniprot id: A0A4X1VV51
uniprot id: F1SV24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9823:CPN1
gene id: 9823:CPN1
uniprot id: A0A4X1U4Z6
uniprot id: F1S8V7
names: Similarity
messages: Belongs to the peptidase M14 family.

9823:ANAPC15
gene id: 9823:ANAPC15
uniprot id: A0A4X1V0Y8
uniprot id: A0A4X1V3L2
uniprot id: A0A8D1C3A3
uniprot id: F1SUX1
names: Similarity
messages: Belongs to the APC15 family.

9823:ADGRF4
gene id: 9823:ADGRF4
uniprot id: A0A8D1TX12
uniprot id: I3LB22
names: Subcellular Location Annotation
messages: Membrane

9823:POR
gene id: 9823:POR
uniprot id: P04175
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9823:COMT
gene id: 9823:COMT
uniprot id: A0A4X1URU2
uniprot id: D3K5L3
uniprot id: F1RHN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
messages: Cell membrane

9823:SGO1
gene id: 9823:SGO1
uniprot id: A0A4X1UJE9
uniprot id: F1RS59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9823:RNASEH1
gene id: 9823:RNASEH1
uniprot id: A0A480VGJ6
uniprot id: A0A4X1UGW6
uniprot id: I3LTQ9
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9823:SAMHD1
gene id: 9823:SAMHD1
uniprot id: A0A023VTS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9823:LOC100525483
gene id: 9823:LOC100525483
uniprot id: F1SDC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9823:RRAGC
gene id: 9823:RRAGC
uniprot id: A0A480LYP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9823:RPLP1
gene id: 9823:RPLP1
uniprot id: A1XQU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9823:PITX1
gene id: 9823:PITX1
uniprot id: A0A4X1UYM8
uniprot id: F8SIP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9823:RAD23A
gene id: 9823:RAD23A
uniprot id: A0A4X1TDA9
uniprot id: A0A8D0M863
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9823:SLC16A1
gene id: 9823:SLC16A1
uniprot id: A0A8D1JG73
uniprot id: B2CZF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9823:S100A12
gene id: 9823:S100A12
uniprot id: P80310
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the S-100 family.
messages: Cell membrane
messages: Cytoplasm
messages: Found essentially in granulocytes with small amounts found in lymphocytes.
messages: Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions. Interacts with AGER and both calcium and zinc are essential for the interaction (By similarity). Interacts with CACYBP in a calcium-dependent manner (By similarity).
messages: In the absence of zinc binds one calcium ion per molecule, in the presence of zinc binds two calcium ions per molecule.
messages: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites (By similarity).
messages: Secreted
messages: The hinge domain contributes significantly to its chemotactic properties.
messages: cytoskeleton

9823:CD53
gene id: 9823:CD53
uniprot id: A0A4X1TCS7
uniprot id: F1S628
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:SLC25A19
gene id: 9823:SLC25A19
uniprot id: C8C418
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:LAMTOR2
gene id: 9823:LAMTOR2
uniprot id: A0A4X1VU19
uniprot id: F2Z518
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9823:CHDH
gene id: 9823:CHDH
uniprot id: A0A4X1VKR3
uniprot id: F1SH89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GMC oxidoreductase family.
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9823:GSTK1
gene id: 9823:GSTK1
uniprot id: A0A4X1V0V8
uniprot id: F1SRV4
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9823:RNF121
gene id: 9823:RNF121
uniprot id: A0A8D1FPC6
uniprot id: A0A8D1JK65
uniprot id: F1SUY6
names: Subcellular Location Annotation
messages: Membrane

9823:FZR1
gene id: 9823:FZR1
uniprot id: A0A4X1VSL5
uniprot id: Q5H7B9
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9823:LOC100158121
gene id: 9823:LOC100158121
uniprot id: A0A4X1VJH6
uniprot id: F2Z587
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:ANXA11
gene id: 9823:ANXA11
uniprot id: A0A4X1SIH1
uniprot id: F1S2E2
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9823:ODF2
gene id: 9823:ODF2
uniprot id: D9IFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9823:UABP-2
gene id: 9823:UABP-2
uniprot id: P46202
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. UTMP subfamily.
messages: extracellular space

9823:CSN1S2
gene id: 9823:CSN1S2
uniprot id: P39036
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9823:LOC100153661
gene id: 9823:LOC100153661
uniprot id: Q0GC42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:CEBPD
gene id: 9823:CEBPD
uniprot id: A0A8D1IY46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9823:NELFE
gene id: 9823:NELFE
uniprot id: A0A4X1VC67
uniprot id: A5PEZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

9823:PSPH
gene id: 9823:PSPH
uniprot id: A0A4X1T1U6
uniprot id: F1RIU1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

9823:HOMEZ
gene id: 9823:HOMEZ
uniprot id: A0A4X1SF05
uniprot id: I3LJG9
names: Subcellular Location Annotation
messages: Nucleus

9823:CENPL
gene id: 9823:CENPL
uniprot id: A0A480DK06
uniprot id: A0A4X1UEK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9823:OTUD7B
gene id: 9823:OTUD7B
uniprot id: A0A4X1SHT5
uniprot id: F1SDG3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:IKBKG
gene id: 9823:IKBKG
uniprot id: A9QT41
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Cleaved by porcine reproductive and respiratory syndrome virus serine protease nsp4 after Glu-349. The cleavage inhibits NEMO proper function.
messages: Cytoplasm
messages: Homodimer; disulfide-linked. Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex (By similarity). The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65 (By similarity). Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2, TRPC4AP and PIDD1. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts with IKBKE. Interacts with TANK; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with ZFAND5. Interacts with RIPK2. Interacts with TNIP1 and TNFAIP3; TNIP1 facilitates the TNFAIP3-mediated de-ubiquitination of IKBKG. Interacts with TNFAIP3; the interaction is induced by TNF stimulation and by polyubiquitin. Binds (via UBAN region) polyubiquitin; binds both 'Lys-63'-linked and linear polyubiquitin, with higher affinity for linear ubiquitin. Interacts with NLRP10. Interacts with TANK; this interaction increases in response to DNA damage. Interacts with USP10; this interaction increases in response to DNA damage. Interacts with ZC3H12A; this interaction increases in response to DNA damage. Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation. Interacts with TRIM29; this interaction induces IKBKG/NEMO ubiquitination and proteolytic degradation. Interacts with TRIM13; this interaction leads to IKBKG/NEMO ubiquitination. Interacts with ARFIP2 (By similarity). Interacts with RIPK1 (By similarity). Interacts with (ubiquitinated) BCL10; interaction with polyubiquitinated BCL10 via both 'Lys-63'-linked and linear ubiquitin is required for TCR-induced NF-kappa-B acti…
messages: Neddylated by TRIM40, resulting in stabilization of NFKBIA and down-regulation of NF-kappa-B activity.
messages: Nucleus
messages: Phosphorylation at Ser-68 attenuates aminoterminal homodimerization.
messages: Polyubiquitinated on Lys-285 through 'Lys-63'; the ubiquitination is mediated by NOD2 and RIPK2 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Polyubiquitinated on Lys-399 through 'Lys-63'; the ubiquitination is mediated by BCL10, MALT1 and TRAF6 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Monoubiquitinated on Lys-277 and Lys-309; promotes nuclear export. Polyubiquitinated through 'Lys-27' by TRIM23; involved in antiviral innate and inflammatory responses. Linear polyubiquitinated on Lys-111, Lys-143, Lys-226, Lys-246, Lys-264, Lys-277, Lys-285, Lys-292, Lys-302, Lys-309 and Lys-326; the head-to-tail polyubiquitination is mediated by the LUBAC complex and plays a key role in NF-kappa-B activation. Deubiquitinated by USP10 in a TANK-dependent and -independent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage. Ubiquitinated at Lys-326 by MARCHF2 following bacterial and viral infection which leads to its degradation (By similarity).
messages: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much highr affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
messages: Sumoylated on Lys-277 and Lys-309 with SUMO1; the modification results in phosphorylation of Ser-85 by ATM leading to a replacement of the sumoylation by mono-ubiquitination on these residues.
messages: The leucine-zipper domain and the CCHC NOA-type zinc-fingers constitute the UBAN region and are essential for polyubiquitin binding and for the activation of IRF3.

9823:GGT5
gene id: 9823:GGT5
uniprot id: A0A8D1Y038
uniprot id: F1RLR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9823:GJC1
gene id: 9823:GJC1
uniprot id: A4GVD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:KEF22 p09
gene id: 9823:KEF22_p09
uniprot id: Q35914
uniprot id: Q7IIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9823:MRPS18A
gene id: 9823:MRPS18A
uniprot id: A0A8D0LTY3
names: Subcellular Location Annotation
messages: Mitochondrion

9823:CAPN7
gene id: 9823:CAPN7
uniprot id: A0FKG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Nucleus

9823:KLF9
gene id: 9823:KLF9
uniprot id: P79288
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Interacts with ZZEF1.
messages: Nucleus
messages: Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation.

9823:FIBIN
gene id: 9823:FIBIN
uniprot id: A0A4X1SYB1
uniprot id: I3L9M3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9823:ALG5
gene id: 9823:ALG5
uniprot id: A0A4X1T2U6
uniprot id: F1RS38
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9823:TMEM86B
gene id: 9823:TMEM86B
uniprot id: A0A8D0XJW7
uniprot id: F1RMN2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM86 family.
messages: Competitively inhibited by lysophosphatidic acid.
messages: Cytoplasm
messages: Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.
messages: Homodimer.
messages: Membrane

9823:ATP1A1
gene id: 9823:ATP1A1
uniprot id: P05024
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Melanosome
messages: Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-941 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1 (PubMed:15563542). Interacts with regulatory subunit FXYD3 (By similarity). Interacts with SIK1 (By similarity). Interacts with SLC35G1 and STIM1 (By similarity). Interacts with CLN3; this interaction regulates the sodium/potassium-transporting ATPase complex localization at the plasma membrane (By similarity).
messages: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
messages: axon
messages: sarcolemma

9823:TYW3
gene id: 9823:TYW3
uniprot id: Q19QT9
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).

9823:RELL2
gene id: 9823:RELL2
uniprot id: A0A8D0JKZ1
uniprot id: F1RMS4
names: Similarity
messages: Belongs to the RELT family.

9823:LOC100155381
gene id: 9823:LOC100155381
uniprot id: A0A8D1AMG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CCDC58
gene id: 9823:CCDC58
uniprot id: A0A8D1HB26
uniprot id: I3LE14
names: Similarity
messages: Belongs to the MIX23 family.

9823:IAH1
gene id: 9823:IAH1
uniprot id: A0A287B3A3
uniprot id: A0A287BPE6
uniprot id: A0A4X1UGA2
uniprot id: A0A8D0Q2C8
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9823:EPHX1
gene id: 9823:EPHX1
uniprot id: A0A480XW48
uniprot id: P79381
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity).
messages: Endoplasmic reticulum membrane
messages: Inhibited by 10-hydroxystearamide and methoxy-arachidonyl fluorophosphate.
messages: Microsome membrane

9823:BAP1
gene id: 9823:BAP1
uniprot id: A0A4X1VP54
uniprot id: K9IVT5
names: Similarity
messages: Belongs to the peptidase C12 family.

9823:RARRES2
gene id: 9823:RARRES2
uniprot id: A0A4X1UJ96
uniprot id: B0LUW3
names: Subcellular Location Annotation
messages: Secreted

9823:ACTN1
gene id: 9823:ACTN1
uniprot id: A0A480J3H1
names: Similarity
messages: Belongs to the alpha-actinin family.

9823:PNMA2
gene id: 9823:PNMA2
uniprot id: A0A8D1I4N4
uniprot id: F1RJT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNMA family.
messages: nucleolus

9823:MYO5C
gene id: 9823:MYO5C
uniprot id: A0A287ARB4
uniprot id: A0A8D0Z5A6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9823:AR
gene id: 9823:AR
uniprot id: A0A4X1VUS1
uniprot id: F1RTM6
uniprot id: Q9GKL7
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with MACROD1 (via macro domain) (By similarity). Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 (via coiled coil domain). Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1. Interacts with CCAR1 and GATA2. Interacts with ZNF318. Interacts with BUD31. Interacts with ARID4A. Interacts with ARID4B. Interacts (via NR LBD domain) with ZBTB7A; the interaction is direct and androgen-dependent (By similarity). Interacts with NCOR1 (By similarity). Interacts with NCOR2 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain (By similarity).
messages: Cytoplasm
messages: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
messages: Nucleus
messages: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).
messages: Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-511 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity). Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity. Phosphorylation at Ser-65 by CDK9 regulates AR promoter selectivity and cell growth (By similarity).
messages: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
messages: Sumoylated on Lys-378 (major) and Lys-497 (By similarity). Ubiquitinated. Deubiquitinated by USP26 (By similarity). 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity (By similarity).
messages: Transcriptional activity is enhanced by binding to RANBP9.

9823:PLPPR2
gene id: 9823:PLPPR2
uniprot id: A0A480P861
uniprot id: A0A4X1VL51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9823:HPCA
gene id: 9823:HPCA
uniprot id: Q06AT1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the recoverin family.
messages: Binds 3 calcium via EF-hand domains. The cryptic EF-hand 1 does not bind calcium.
messages: Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases.
messages: Membrane
messages: Myristoylation facilitates association with membranes.
messages: Oligomer; oligomerization is calcium-dependent. May interact with the voltage-dependent P/Q- and N-type calcium channels CACNA1A and CACNA1B.
messages: cytosol

9823:TNFRSF1A
gene id: 9823:TNFRSF1A
uniprot id: P50555
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway. Interacts with SH3RF2, TRADD and RIPK1. SH3RF2 facilitates the recruitment of RIPK1 and TRADD to TNFRSF1A in a TNF-alpha-dependent process. Interacts with PGLYRP1; this interaction is important for cell death induction. Interacts (via death domain) with MADD (via death domain) (By similarity).
messages: Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).

9823:PGLYRP3
gene id: 9823:PGLYRP3
uniprot id: A0A8D0J2M5
uniprot id: F8WK49
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9823:TBX2
gene id: 9823:TBX2
uniprot id: A0A4X1ST68
uniprot id: F8SIP4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:KDSR
gene id: 9823:KDSR
uniprot id: A0A4X1TPM8
uniprot id: F1SMW5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:CX3CR1
gene id: 9823:CX3CR1
uniprot id: A0A4X1TT40
uniprot id: I3LAU2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9823:TNFAIP1
gene id: 9823:TNFAIP1
uniprot id: A0A4X1TLU4
uniprot id: I3LM60
names: Similarity
messages: Belongs to the BACURD family.

9823:FABP1
gene id: 9823:FABP1
uniprot id: P49924
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: Monomer.
messages: Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.

9823:BLVRA
gene id: 9823:BLVRA
uniprot id: A0A480V8U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

9823:STXBP5
gene id: 9823:STXBP5
uniprot id: A0A4X1VQV1
uniprot id: A0A4X1VSR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9823:MOCS3
gene id: 9823:MOCS3
uniprot id: A5GFZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

9823:SYNE2
gene id: 9823:SYNE2
uniprot id: A0A480L0G3
uniprot id: A0A4X1WCF0
names: Similarity
messages: Belongs to the nesprin family.

9823:TPST2
gene id: 9823:TPST2
uniprot id: A0A4X1SIB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9823:S100A3
gene id: 9823:S100A3
uniprot id: A0A4X1VZZ8
uniprot id: F1SFV6
names: Similarity
messages: Belongs to the S-100 family.

9823:TBX20
gene id: 9823:TBX20
uniprot id: A0A4X1W134
uniprot id: A0A8D0LL18
uniprot id: F1SIK8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:OVOL1
gene id: 9823:OVOL1
uniprot id: A0A4X1UIC6
uniprot id: F1RU16
names: Subcellular Location Annotation
messages: Nucleus

9823:BPNT1
gene id: 9823:BPNT1
uniprot id: A0A287A722
uniprot id: A0A480YFB5
uniprot id: A0A4X1TP75
uniprot id: A0A4X1TPB6
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9823:DYNLT1
gene id: 9823:DYNLT1
uniprot id: A0A4X1VW90
uniprot id: B8Y650
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9823:C6H18orf21
gene id: 9823:C6H18orf21
uniprot id: A0A481BD10
uniprot id: A0A4X1VD73
names: Similarity
messages: Belongs to the UPF0711 family.

9823:IL11RA
gene id: 9823:IL11RA
uniprot id: A0A4X1USE8
uniprot id: F1S3U2
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9823:KEF22 p04
gene id: 9823:KEF22_p04
uniprot id: O79881
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9823:N4BP3
gene id: 9823:N4BP3
uniprot id: A0A8D0W086
uniprot id: F1S3E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Vesicle
messages: axon
messages: dendrite

9823:AIMP2
gene id: 9823:AIMP2
uniprot id: A0A8D1QVJ3
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9823:RAP2C
gene id: 9823:RAP2C
uniprot id: A0A8D0PIG5
uniprot id: I3LH60
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9823:SSTR2
gene id: 9823:SSTR2
uniprot id: A0A480ZK14
uniprot id: P34994
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain) (By similarity).
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization (By similarity).
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9823:EI24
gene id: 9823:EI24
uniprot id: A0A480ECU0
uniprot id: A0A4X1VJ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

9823:DGCR14
gene id: 9823:DGCR14
uniprot id: A0A4X1UQD0
uniprot id: F1RK78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9823:RDH5
gene id: 9823:RDH5
uniprot id: A0A8D0RS66
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:CAMK2D
gene id: 9823:CAMK2D
uniprot id: Q95266
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity (By similarity).
messages: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD CACNB2 (By similarity).
messages: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimu…
messages: Sarcoplasmic reticulum membrane
messages: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
messages: sarcolemma

9823:TRIM50
gene id: 9823:TRIM50
uniprot id: Q865W2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300 and KAT2B. HDAC6 drives TRIM50 deacetylation. Acetylation antagonizes with TRIM50 ubiquitination.
messages: Auto-ubiquitinated.
messages: Belongs to the TRIM/RBCC family.
messages: Can form dimers and trimers. Interacts with several E2 ubiquitin-conjugating enzymes, including UBE2L6, UBE2E1, UBE2E3. No interaction with UBE2H. Interacts with BECN1. Interacts with SQSTM1.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.

9823:LOC100738403
gene id: 9823:LOC100738403
uniprot id: A0A480J7X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9823:CKMT1A
gene id: 9823:CKMT1A
uniprot id: A0A4X1VA58
uniprot id: F1SI77
uniprot id: Q29577
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Exists as an octamer composed of four MTCK homodimers.
messages: Mitochondrial creatine kinase binds cardiolipin.
messages: Mitochondrion inner membrane
messages: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).

9823:LHX1
gene id: 9823:LHX1
uniprot id: A0A4X1SZB4
uniprot id: F2Z531
names: Subcellular Location Annotation
messages: Nucleus

9823:RTN4
gene id: 9823:RTN4
uniprot id: A0A287B5Q4
uniprot id: A0A4X1W6J5
uniprot id: A0A4X1WDD7
uniprot id: A0A8D1EXL5
uniprot id: Q6IM70
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:CCDC90B
gene id: 9823:CCDC90B
uniprot id: A0A4X1UAD5
uniprot id: F1STU7
names: Similarity
messages: Belongs to the CCDC90 family.

9823:NTRK1
gene id: 9823:NTRK1
uniprot id: A0A4X1VSL3
uniprot id: F1RHK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9823:STX12
gene id: 9823:STX12
uniprot id: A0A8D0XI23
names: Similarity
messages: Belongs to the syntaxin family.

9823:GPX8
gene id: 9823:GPX8
uniprot id: A0A4X1SMA7
uniprot id: A0A4X1SMQ0
uniprot id: A0A5G2R5V6
uniprot id: A0A8D0MZI3
uniprot id: F1SLM7
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9823:IRGC
gene id: 9823:IRGC
uniprot id: D7EZJ4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9823:MDGA1
gene id: 9823:MDGA1
uniprot id: A0A4X1SRT3
uniprot id: F1RVR8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SLC25A34
gene id: 9823:SLC25A34
uniprot id: A0A480RCV7
uniprot id: A0A8D1TEY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:RNASE6
gene id: 9823:RNASE6
uniprot id: P81649
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pancreatic ribonuclease family.
messages: Cytoplasmic granule
messages: Interacts (via N-terminus) with bacterial lipopolysaccharide (LPS).
messages: Kidney.
messages: Lysosome
messages: Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:7764367). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (By similarity). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility (By similarity). Bactericidal activity is independent of RNase activity (By similarity).
messages: Secreted

9823:SLC6A14
gene id: 9823:SLC6A14
uniprot id: A0A4X1W4T9
uniprot id: C8CBZ0
uniprot id: K7GNX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9823:SLC11A1
gene id: 9823:SLC11A1
uniprot id: O77741
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (By similarity).
messages: Membrane

9823:LOC100517700
gene id: 9823:LOC100517700
uniprot id: F1S3F9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CPEB1
gene id: 9823:CPEB1
uniprot id: A4PES2
names: Similarity
messages: Belongs to the RRM CPEB family.

9823:TIMP2
gene id: 9823:TIMP2
uniprot id: A0A4X1UID2
uniprot id: C0JPM4
names: Similarity
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

9823:TRAM1L1
gene id: 9823:TRAM1L1
uniprot id: A0A4X1V588
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9823:PTP4A1
gene id: 9823:PTP4A1
uniprot id: A0A4X1T9Z7
uniprot id: K9IWI1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9823:CTPS2
gene id: 9823:CTPS2
uniprot id: A0A4X1UU82
uniprot id: A0A5G2QBK2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9823:SLC5A3
gene id: 9823:SLC5A3
uniprot id: A0A287A6C9
uniprot id: A0A8D0MUJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9823:ETV5
gene id: 9823:ETV5
uniprot id: A0A8D0JX33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:FOXJ1
gene id: 9823:FOXJ1
uniprot id: A0A8D1JDT5
uniprot id: F1RWM7
names: Subcellular Location Annotation
messages: Nucleus

9823:TAT
gene id: 9823:TAT
uniprot id: A0A8D1B593
uniprot id: F1S3D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9823:NDUFA6
gene id: 9823:NDUFA6
uniprot id: A0A480VKQ8
uniprot id: A0A8D0IX28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:PSMB7
gene id: 9823:PSMB7
uniprot id: A1XQU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9823:PPCS
gene id: 9823:PPCS
uniprot id: A0A4X1W858
uniprot id: F1SF93
names: Similarity
messages: Belongs to the PPC synthetase family.

9823:EIF2AK3
gene id: 9823:EIF2AK3
uniprot id: A0A480XY09
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9823:TPM2
gene id: 9823:TPM2
uniprot id: A0A4X1VWM4
uniprot id: A0A8D1DIF5
uniprot id: A1X899
uniprot id: F1SG00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9823:CFL1
gene id: 9823:CFL1
uniprot id: P10668
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the actin-binding proteins ADF family.
messages: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:6509022, PubMed:9078368). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:9078368). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
messages: Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (PubMed:6509022, PubMed:9078368). It is a major component of intranuclear and cytoplasmic actin rods (PubMed:9078368). Interacts with the subcortical maternal complex (SCMC) via interaction with TLE6 and NLRP5 (By similarity). Interacts with C9orf72 (By similarity).
messages: Inactivated by phosphorylation on Ser-3 (PubMed:9078368). Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2 (By similarity).
messages: Nucleus matrix
messages: Widely distributed in various tissues.
messages: axon
messages: cytoskeleton
messages: growth cone
messages: lamellipodium
messages: lamellipodium membrane
messages: ruffle membrane

9823:CPE
gene id: 9823:CPE
uniprot id: A0A4X1U8W8
uniprot id: A1IU54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Interacts with Secretogranin III/SCG3.
messages: Membrane
messages: Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
messages: secretory vesicle membrane

9823:NANOG
gene id: 9823:NANOG
uniprot id: Q1W1Y4
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100523887
gene id: 9823:LOC100523887
uniprot id: A0A5G2QBN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:KCNJ3
gene id: 9823:KCNJ3
uniprot id: A0A4X1VSE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9823:LOC100517239
gene id: 9823:LOC100517239
uniprot id: A0A4X1T869
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:C13H21orf59
gene id: 9823:C13H21orf59
uniprot id: A0A286ZKE9
uniprot id: A0A4X1U411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9823:DAD1
gene id: 9823:DAD1
uniprot id: Q29036
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9823:SLC17A7
gene id: 9823:SLC17A7
uniprot id: A0A8D1TY40
uniprot id: F1RHZ7
names: Subcellular Location Annotation
messages: Membrane

9823:HOXB7
gene id: 9823:HOXB7
uniprot id: A0A4X1UPE5
uniprot id: F1RWG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:SPDEF
gene id: 9823:SPDEF
uniprot id: A0A8D0ZCI2
uniprot id: D5KJI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:NKX3-2
gene id: 9823:NKX3-2
uniprot id: A0A286ZVB8
uniprot id: A0A8D1I2L2
names: Subcellular Location Annotation
messages: Nucleus

9823:KIF20B
gene id: 9823:KIF20B
uniprot id: A0A480QVY1
uniprot id: A0A480ZX77
uniprot id: A0A4X1V1I0
uniprot id: A0A4X1V2Z5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:ZNF18
gene id: 9823:ZNF18
uniprot id: A0A8D0NDE4
names: Subcellular Location Annotation
messages: Nucleus

9823:ACYP1
gene id: 9823:ACYP1
uniprot id: A0A8D0Z570
uniprot id: J9JIK5
uniprot id: P24540
names: Similarity
names: Tissue Specificity
messages: Belongs to the acylphosphatase family.
messages: Organ-common type isozyme is found in many different tissues.

9823:LOC100623541
gene id: 9823:LOC100623541
uniprot id: A0A4X1VZ45
uniprot id: I3L9A0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:GPD1
gene id: 9823:GPD1
uniprot id: A0A287BDV9
uniprot id: A0A4X1WCQ0
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9823:PRM2
gene id: 9823:PRM2
uniprot id: P19757
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protamine P2 family.
messages: Chromosome
messages: Interacts with TDRP.
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Proteolytic processing into mature chains is required for histone eviction during spermatogenesis. Transition proteins (TNP1 and TNP2) are required for processing.
messages: Testis.

9823:CYP1A1
gene id: 9823:CYP1A1
uniprot id: A0A4X1TMV9
uniprot id: Q8SQ69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9823:GANAB
gene id: 9823:GANAB
uniprot id: A0A4X1VKG9
uniprot id: I3LNH3
uniprot id: P79403
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.
messages: Contains sialylated polysaccharide chains.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH). Binds glycosylated PTPRC.
messages: Melanosome

9823:SH3BGR
gene id: 9823:SH3BGR
uniprot id: A0A8D0WIU2
names: Similarity
messages: Belongs to the SH3BGR family.

9823:LOC100738896
gene id: 9823:LOC100738896
uniprot id: A0A0G3VNL1
uniprot id: A0A4X1TRD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:TRPC5
gene id: 9823:TRPC5
uniprot id: A0A4X1W5M5
uniprot id: A1E2E5
uniprot id: F1RWU0
names: Subcellular Location Annotation
messages: Membrane

9823:SPIB
gene id: 9823:SPIB
uniprot id: A0A4X1VVR0
uniprot id: A0A8D1JXL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:LDHA
gene id: 9823:LDHA
uniprot id: A0A4X1T6G7
uniprot id: D2SW96
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9823:BORCS7
gene id: 9823:BORCS7
uniprot id: A0A287B4Y0
uniprot id: A0A4X1TTC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Membrane

9823:SUZ12
gene id: 9823:SUZ12
uniprot id: A0A287A167
uniprot id: A0A4X1TGA6
uniprot id: A0A4X1TK80
uniprot id: F1RKV6
names: Similarity
messages: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

9823:IFNK
gene id: 9823:IFNK
uniprot id: A0A8D0VVG3
uniprot id: C8CKC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:GABRG2
gene id: 9823:GABRG2
uniprot id: A0A287AEH9
uniprot id: A0A4X1TY82
uniprot id: A0A4X1U0U9
uniprot id: F1RR72
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:CPA1
gene id: 9823:CPA1
uniprot id: A0A4X1VSS2
uniprot id: P09954
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity).
messages: Monomer. May form a complex with proelastase 2.
messages: Secreted

9823:NXPH3
gene id: 9823:NXPH3
uniprot id: A0A4X1UM08
uniprot id: F1RTC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9823:SLC6A8
gene id: 9823:SLC6A8
uniprot id: C6KE31
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.
messages: Cell membrane
messages: Membrane

9823:NEU3
gene id: 9823:NEU3
uniprot id: A0A286ZR19
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9823:STARD3
gene id: 9823:STARD3
uniprot id: A0A480JT76
uniprot id: A0A4X1UIX1
uniprot id: B8XSJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9823:EPHX2
gene id: 9823:EPHX2
uniprot id: Q6Q2C2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
messages: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:15308618). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (By similarity).
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited by 1-(1-acetylpiperidin-4-yl)-3-(4-(trifl uoromethoxy)phenyl)urea (TPAU), 1-cyclohexyl-3-dodecylurea (CDU), 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), 1-((3S, 5S, 7S)-adamantan-1-yl)-3-(5-(2-(2-ethoxyethoxy) ethoxy)pentyl)urea (AEPU), N-adamantyl-N[']-cyclohexyl urea (ACU), 4-(((1S, 4S)-4-(3-((3S, 5S, 7S)-adamantan-1-yl) ureido)cyclohexyl)oxy)benzoic acid (c-AUCB), 4-(((1R, 4R)-4-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido)cyclohexyl)oxy)benzoic acid (t-AUCB), 4-(((1R, 4R)-4-(3-(4(trifluoromethoxy)phenyl)ureido)cyclohexyl)oxy)benzoic acid (t-TAUCB) and to a lesser extent by 8-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido) octanoic acid (AUOA).
messages: Peroxisome
messages: The N-terminal domain has phosphatase activity. The C-terminal domain has epoxide hydrolase activity.
messages: The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (By similarity).

9823:MYOCD
gene id: 9823:MYOCD
uniprot id: Q7YR76
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the heart and in smooth muscle cells-containing tissues (aorta, pulmonary vein, lung), but is not detectable in skeletal muscle, liver, kidney and spleen.
messages: Homodimer. Interacts with MLLT7/FOXO4. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation (By similarity). Interacts (via C-terminal) with EP300 (via the CREB-binding domain) (By similarity). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C (By similarity).
messages: Nucleus
messages: Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.
messages: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).
messages: The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation (By similarity).

9823:FOLH1B
gene id: 9823:FOLH1B
uniprot id: O77564
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity.
messages: Cell membrane
messages: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate.
messages: High expression in the duodenum and in the jejunum brush-border membrane. Weak expression in kidney.
messages: Homodimer.
messages: The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
messages: The NAALADase activity is inhibited by quisqualic acid, beta-NAAG and 2-(phosphonomethyl) pentanedioic acid (PMPA). Ethanol ingestion decreases the folate hydrolase activity by 50%.

9823:ELP2
gene id: 9823:ELP2
uniprot id: A0A8D1Q5N6
uniprot id: I3L616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

9823:DLX2
gene id: 9823:DLX2
uniprot id: A0A4X1V562
uniprot id: F1S082
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9823:SCAMP2
gene id: 9823:SCAMP2
uniprot id: A0A481C191
uniprot id: A0A4X1TRJ9
uniprot id: A0A5G2R660
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9823:MRPL28
gene id: 9823:MRPL28
uniprot id: A0A286ZTW8
uniprot id: A0A480V5G3
uniprot id: A0A4X1UJL0
uniprot id: A0A4X1UPV4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

9823:SOX9
gene id: 9823:SOX9
uniprot id: F1RV30
uniprot id: O18896
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated; acetylation impairs nuclear localization and ability to transactivate expression of target genes. Deacetylated by SIRT1.
messages: Homodimer; homodimerization is required for activity. Interacts (via C-terminus) with ZNF219; forming a complex that binds to the COL2A1 promoter and activates COL2A1 expression (By similarity). Interacts with DDRGK1. Interacts with EP300/p300 (By similarity). Interacts with beta-catenin (CTNNB1); inhibiting CTNNB1 activity by competing with the binding sites of TCF/LEF within CTNNB1 (By similarity).
messages: Nucleus
messages: Phosphorylation at Ser-64 and Ser-211 by PKA increases transcriptional activity and may help delay chondrocyte maturation downstream of PTHLH/PTHrP signaling. Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation. Phosphorylated on tyrosine residues; tyrosine dephosphorylation by PTPN11/SHP2 blocks SOX9 phosphorylation by PKA and subsequent SUMOylation.
messages: Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation. Sumoylation is induced by BMP signaling pathway.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The PQA region (for proline, glutamine and alanine-rich) helps stabilize SOX9 and facilitates transactivation. It lacks intrinsic transactivation capability.
messages: The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.
messages: Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6. Also binds to some promoter regions. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes. Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in…
messages: Ubiquitinated; ubiquitination leads to proteasomal degradation and is negatively regulated by DDRGK1.

9823:MRS2
gene id: 9823:MRS2
uniprot id: A0A8D1CC06
uniprot id: F1RUF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

9823:HMGB2
gene id: 9823:HMGB2
uniprot id: P17741
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMGB family.
messages: Both, HMG box 1 and HMG box 2, show antimicrobial activity.
messages: Chromosome
messages: Cytoplasm
messages: Interacts with POU2F2, POU2F1 and POU3F1. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with LEF1.
messages: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11275566). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity. May play a role in germ cell differentiation. Involved in modulation of neurogenesis probably by regulation of neural stem proliferation. Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
messages: Nucleus
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).
messages: Secreted

9823:UBE3A
gene id: 9823:UBE3A
uniprot id: A0A287A5W0
uniprot id: A0A480ZYU3
uniprot id: A0A4X1UDR2
uniprot id: A0A4X1UEY4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9823:TCEA1
gene id: 9823:TCEA1
uniprot id: A0A4X1T3C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9823:LACTB2
gene id: 9823:LACTB2
uniprot id: A0A4X1UPG1
uniprot id: F1RU12
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9823:DDX59
gene id: 9823:DDX59
uniprot id: A0A287BS13
uniprot id: A0A4X1SMN0
uniprot id: I3LV06
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

9823:POT1
gene id: 9823:POT1
uniprot id: A0A287A5Z9
uniprot id: A0A8D0MUL6
uniprot id: B6DT13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9823:PON2
gene id: 9823:PON2
uniprot id: B1PK14
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9823:HSPA2
gene id: 9823:HSPA2
uniprot id: A0A8E8U5E5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9823:HPS5
gene id: 9823:HPS5
uniprot id: A5A774
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9823:CDC42EP2
gene id: 9823:CDC42EP2
uniprot id: A0A4X1TEX2
uniprot id: F1RQV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9823:DDO
gene id: 9823:DDO
uniprot id: A3KCL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome
messages: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.

9823:CD34
gene id: 9823:CD34
uniprot id: Q8WMG9
names: Subcellular Location Annotation
messages: Membrane

9823:MAPK6
gene id: 9823:MAPK6
uniprot id: A0A4X1T4B3
uniprot id: F1RZB8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9823:MAP2K1
gene id: 9823:MAP2K1
uniprot id: B8XSJ8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:RGMA
gene id: 9823:RGMA
uniprot id: A0A287BPV6
uniprot id: A0A4X1UJU6
uniprot id: A0A4X1UKI0
uniprot id: F1SA76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9823:SERP1
gene id: 9823:SERP1
uniprot id: A0A286ZIJ7
uniprot id: A0A4X1SYZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9823:NDUFA3
gene id: 9823:NDUFA3
uniprot id: A0A4X1VQ42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9823:BCLAF1
gene id: 9823:BCLAF1
uniprot id: A0A286ZMT9
uniprot id: A0A287AKI0
uniprot id: A0A4X1VK93
uniprot id: A0A4X1VL28
uniprot id: A0A8D0XBI1
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9823:PALM3
gene id: 9823:PALM3
uniprot id: A0A4X1V4V0
uniprot id: F1SD58
names: Similarity
messages: Belongs to the paralemmin family.

9823:THBS1
gene id: 9823:THBS1
uniprot id: A0A4X1URL0
uniprot id: F1SS26
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100737875
gene id: 9823:LOC100737875
uniprot id: A0A480EBE0
uniprot id: A0A8D1XHC5
names: Subcellular Location Annotation
messages: Membrane

9823:STT3B
gene id: 9823:STT3B
uniprot id: A0A4X1UDA4
uniprot id: F1RRF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9823:KLF17
gene id: 9823:KLF17
uniprot id: C7EMF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

9823:GSTO1
gene id: 9823:GSTO1
uniprot id: A0A481BZ29
uniprot id: Q9N1F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
messages: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
messages: Homodimer.
messages: Most abundant in the liver and skeletal muscle; also expressed in heart, diaphragm, colon, thymus, kidney, lung, ovaries, spleen, intestine and pancreas.
messages: cytosol

9823:TBRG1
gene id: 9823:TBRG1
uniprot id: A0A4X1VH38
uniprot id: I3LBA2
names: Subcellular Location Annotation
messages: Nucleus

9823:EIF6
gene id: 9823:EIF6
uniprot id: A0A4X1T930
uniprot id: I3L8I5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9823:TOR1A
gene id: 9823:TOR1A
uniprot id: A0A4X1THU4
uniprot id: A7YX23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum lumen
messages: Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane.
messages: Membrane
messages: growth cone

9823:HNRNPF
gene id: 9823:HNRNPF
uniprot id: A0A4X1U566
uniprot id: F1RG16
names: Subcellular Location Annotation
messages: nucleoplasm

9823:TLX3
gene id: 9823:TLX3
uniprot id: A0A8D1GR04
names: Subcellular Location Annotation
messages: Nucleus

9823:SORD
gene id: 9823:SORD
uniprot id: A0A480UJV9
uniprot id: A0A4X1VDW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 1 or 2 Zn(2+) ions per subunit.
messages: Homotetramer.
messages: Mitochondrion membrane
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
messages: flagellum

9823:PNPT1
gene id: 9823:PNPT1
uniprot id: F8SIP3
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

9823:MCRIP2
gene id: 9823:MCRIP2
uniprot id: A0A4X1SHE9
uniprot id: F1RGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9823:TMEM39A
gene id: 9823:TMEM39A
uniprot id: A0A4X1T334
uniprot id: F1SPA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9823:HMGA2
gene id: 9823:HMGA2
uniprot id: A0A4X1VY34
uniprot id: G3FNU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9823:DMRT1
gene id: 9823:DMRT1
uniprot id: Q9TT01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus
messages: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

9823:TYSND1
gene id: 9823:TYSND1
uniprot id: A0A8D0MJV2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

9823:LOC100516039
gene id: 9823:LOC100516039
uniprot id: A0A8D1UP34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:GAB1
gene id: 9823:GAB1
uniprot id: A0A480ZFM5
uniprot id: A0A8D1U4K7
names: Similarity
messages: Belongs to the GAB family.

9823:JMJD1C
gene id: 9823:JMJD1C
uniprot id: A0A8D0V5P5
uniprot id: A0A8D2BH89
names: Subcellular Location Annotation
messages: Nucleus

9823:CCM2L
gene id: 9823:CCM2L
uniprot id: A0A8D1W4Y8
uniprot id: F1S526
names: Similarity
messages: Belongs to the CCM2 family.

9823:GUCA2B
gene id: 9823:GUCA2B
uniprot id: O13009
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity).
messages: Secreted

9823:SEBOX
gene id: 9823:SEBOX
uniprot id: A0A8D1JTE2
uniprot id: I3LKQ4
names: Subcellular Location Annotation
messages: Nucleus

9823:CASTOR1
gene id: 9823:CASTOR1
uniprot id: A0A4X1VBI5
uniprot id: A0A4X1VCG3
uniprot id: A0A8D0J911
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

9823:ST14
gene id: 9823:ST14
uniprot id: A0A287AP26
uniprot id: A0A8D0XAY2
uniprot id: A0A8D1B9S9
uniprot id: F1S6D6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Degrades extracellular matrix.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:DMRT2
gene id: 9823:DMRT2
uniprot id: A0A480RGK4
uniprot id: A0A4X1W5X0
uniprot id: A0A4X1W737
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9823:CLDN20
gene id: 9823:CLDN20
uniprot id: A0A8D0IDR3
uniprot id: C3VMW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:PR39
gene id: 9823:PR39
uniprot id: P80054
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cathelicidin family.
messages: Exerts a potent antimicrobial activity against both E.coli and B.megaterium.
messages: Secreted
messages: Small intestine and bone marrow.

9823:LOC100516426
gene id: 9823:LOC100516426
uniprot id: A0A286ZP59
uniprot id: A0A4X1U0H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PHF1
gene id: 9823:PHF1
uniprot id: A0A287BCT8
uniprot id: A0A8D0NID3
uniprot id: A0A8D1GTH5
uniprot id: F1RZR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9823:PA2G4
gene id: 9823:PA2G4
uniprot id: A0A4X1W958
names: Similarity
messages: Belongs to the peptidase M24 family.

9823:C2
gene id: 9823:C2
uniprot id: A5PF02
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:CYP51
gene id: 9823:CYP51
uniprot id: A0A480ND90
uniprot id: O46420
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: In testis, expression levels are low in young animals and increase rapidly after 10 weeks of age.
messages: Inhibited by azalanstat. Inhibited by azole antifungal agents ketoconazole, itraconazole and fluconazole.
messages: Microsome membrane
messages: Strongly expressed in liver and testis. Also detected in kidney, lung and epididymis.

9823:NEFM
gene id: 9823:NEFM
uniprot id: A0A8D1UI82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon
messages: cytoskeleton

9823:LOC100521659
gene id: 9823:LOC100521659
uniprot id: A0A4X1W8J5
uniprot id: F1SLE8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:IL21
gene id: 9823:IL21
uniprot id: Q76LU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity (PubMed:15107555). Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Secreted

9823:MTFMT
gene id: 9823:MTFMT
uniprot id: A0A4X1U587
uniprot id: F1S1X2
names: Similarity
messages: Belongs to the Fmt family.

9823:MMP25
gene id: 9823:MMP25
uniprot id: A0A8D1ABX0
uniprot id: I3LFQ7
names: Similarity
messages: Belongs to the peptidase M10A family.

9823:WIF1
gene id: 9823:WIF1
uniprot id: A0A8D1B219
uniprot id: K7GQ27
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:NDUFB4
gene id: 9823:NDUFB4
uniprot id: A0A287BPW8
uniprot id: A0A4X1T6M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:TMEM265
gene id: 9823:TMEM265
uniprot id: A0A287BBZ1
uniprot id: A0A4X1TQ89
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:LOC100516720
gene id: 9823:LOC100516720
uniprot id: F1S7L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FFAR3
gene id: 9823:FFAR3
uniprot id: A0A8D1ZAQ9
uniprot id: I1X3K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9823:NOTCH4
gene id: 9823:NOTCH4
uniprot id: A5A8X3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9823:NDUFB9
gene id: 9823:NDUFB9
uniprot id: A0A4X1T0A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:ADGRG5
gene id: 9823:ADGRG5
uniprot id: A0A8D0PQQ2
names: Subcellular Location Annotation
messages: Membrane

9823:FZD5
gene id: 9823:FZD5
uniprot id: A0A8D0WIM6
uniprot id: F1SSU5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:PITX2
gene id: 9823:PITX2
uniprot id: F2VU14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9823:GDPD2
gene id: 9823:GDPD2
uniprot id: A0A480PI58
uniprot id: A0A4X1VHU3
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9823:UBE2N
gene id: 9823:UBE2N
uniprot id: A0A8D1GSY1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:IRF4
gene id: 9823:IRF4
uniprot id: A0MZ86
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:CNR1
gene id: 9823:CNR1
uniprot id: A0A8D1ZJJ4
uniprot id: F1S0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.
messages: Interacts (via C-terminus) with CNRIP1.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

9823:DEFB1
gene id: 9823:DEFB1
uniprot id: H9ZGM8
uniprot id: O62697
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
messages: Membrane
messages: Monomer. Homodimer.
messages: Secreted

9823:PKN2
gene id: 9823:PKN2
uniprot id: A0A4X1UCA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9823:COPA
gene id: 9823:COPA
uniprot id: A0A8D0Q593
uniprot id: F1RJX8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9823:DHX58
gene id: 9823:DHX58
uniprot id: A0A4X1U1Q9
uniprot id: E3NZJ4
uniprot id: F1S0P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9823:SGCE
gene id: 9823:SGCE
uniprot id: B8Y4S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Golgi apparatus
messages: cytoskeleton
messages: dendrite
messages: sarcolemma

9823:XKR5
gene id: 9823:XKR5
uniprot id: A0A287BT87
uniprot id: A0A4X1VY56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9823:TRHR
gene id: 9823:TRHR
uniprot id: D5FUH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9823:ZDHHC5
gene id: 9823:ZDHHC5
uniprot id: A0A287AR08
uniprot id: A0A4X1VJS9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:ADAT2
gene id: 9823:ADAT2
uniprot id: A0A287ATE6
uniprot id: A0A4X1VMQ7
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9823:ANKRD13C
gene id: 9823:ANKRD13C
uniprot id: A0A4X1U755
names: Subcellular Location Annotation
messages: Membrane

9823:ACVR2A
gene id: 9823:ACVR2A
uniprot id: E9M2M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9823:BNIP3L
gene id: 9823:BNIP3L
uniprot id: A0A287AJ70
uniprot id: A0A4X1VC55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9823:SLC7A7
gene id: 9823:SLC7A7
uniprot id: A0A4X1V3S9
uniprot id: A8HG48
names: Subcellular Location Annotation
messages: Membrane

9823:FSCN1
gene id: 9823:FSCN1
uniprot id: A0A4X1TSZ4
uniprot id: C0LZL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9823:MTX3
gene id: 9823:MTX3
uniprot id: A0A287AMT3
uniprot id: A0A8D0IME5
uniprot id: A0A8D0IRT4
uniprot id: A0A8D1KCD8
uniprot id: I3LRA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:SLC37A3
gene id: 9823:SLC37A3
uniprot id: A0A480P6F2
uniprot id: A0A8D0VT39
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100520556
gene id: 9823:LOC100520556
uniprot id: A0A4X1TTZ5
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9823:LOC100521773
gene id: 9823:LOC100521773
uniprot id: A0A4X1SXZ4
uniprot id: A0A5G2QU99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100517145
gene id: 9823:LOC100517145
uniprot id: A0A4X1V0B2
uniprot id: F1S3H9
names: Subcellular Location Annotation
messages: Secreted

9823:CYP2C49
gene id: 9823:CYP2C49
uniprot id: Q8SQ65
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:CERS2
gene id: 9823:CERS2
uniprot id: A0A287A843
uniprot id: A0A8D0MHP1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9823:PRR15
gene id: 9823:PRR15
uniprot id: A0A4X1TGE5
uniprot id: F1SIG5
names: Similarity
messages: Belongs to the PRR15 family.

9823:DEFB128
gene id: 9823:DEFB128
uniprot id: A0A287BN95
uniprot id: A0A4X1SQJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:MAT2B
gene id: 9823:MAT2B
uniprot id: B7SU41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9823:KRT33A
gene id: 9823:KRT33A
uniprot id: A0A8D1V1P2
names: Similarity
messages: Belongs to the intermediate filament family.

9823:NR1H2
gene id: 9823:NR1H2
uniprot id: A0A4X1VQ73
uniprot id: F1RH38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:BYSL
gene id: 9823:BYSL
uniprot id: B4X981
names: Similarity
messages: Belongs to the bystin family.

9823:WSCD1
gene id: 9823:WSCD1
uniprot id: A0A8D1RBG9
uniprot id: F1RGL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

9823:UCHL3
gene id: 9823:UCHL3
uniprot id: Q06AB3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3, and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome (By similarity).
messages: Inhibited by monoubiquitin and diubiquitin.
messages: Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates.

9823:ACP7
gene id: 9823:ACP7
uniprot id: A0A4X1SXF6
uniprot id: A0A5G2R0R5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9823:NUDT6
gene id: 9823:NUDT6
uniprot id: A0A480E320
uniprot id: A0A4X1VCA9
uniprot id: A0A5G2QE17
uniprot id: A0A8D0K9P0
uniprot id: A0A8D0N0E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

9823:TPK1
gene id: 9823:TPK1
uniprot id: A0A287AHT7
uniprot id: A0A4X1UMM2
uniprot id: A0A8D1V745
uniprot id: F1SAD1
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9823:MYOC
gene id: 9823:MYOC
uniprot id: A0A4X1UKQ6
uniprot id: Q8HZW2
names: Caution
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion outer membrane
messages: Rough endoplasmic reticulum
messages: cilium
messages: extracellular exosome
messages: extracellular matrix

9823:TRAPPC2L
gene id: 9823:TRAPPC2L
uniprot id: A0A287AMU1
uniprot id: A0A8D0XRF6
uniprot id: A0A8D1MD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9823:LITAF
gene id: 9823:LITAF
uniprot id: A0A287BBP5
uniprot id: A0A4X1VJC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9823:NDUFAF7
gene id: 9823:NDUFAF7
uniprot id: A0A4X1T425
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9823:GABARAPL1
gene id: 9823:GABARAPL1
uniprot id: D7RA27
names: Similarity
messages: Belongs to the ATG8 family.

9823:TUBGCP3
gene id: 9823:TUBGCP3
uniprot id: A0A4X1TX02
uniprot id: F1RN46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9823:RAB1B
gene id: 9823:RAB1B
uniprot id: Q06AU7
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasm
messages: Interacts with MICAL1 and MICAL2. Interacts (in GTP-bound form) with MICALCL, MICAL1 and MILCAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II. Interacts with RabGAP TBC1D20. Interacts (in GDP-bound form) with lipid phosphatase MTMR6 (via GRAM domain); the interaction regulates MTMR6 recruitment to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). Interacts (in GDP-bound form) with lipid phosphatase MTMR7 (By similarity).
messages: Membrane
messages: Preautophagosomal structure membrane
messages: Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).
messages: Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).
messages: perinuclear region

9823:LOC100624541
gene id: 9823:LOC100624541
uniprot id: A0A287ADU1
uniprot id: A0A8D1ALN5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:YIF1B
gene id: 9823:YIF1B
uniprot id: A0A480QFX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9823:CD8A
gene id: 9823:CD8A
uniprot id: A0A287A9Y5
uniprot id: A0A8D1HB99
uniprot id: Q6R2U9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:FTO
gene id: 9823:FTO
uniprot id: A9LN07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fto family.
messages: Cytoplasm
messages: Nucleus speckle

9823:RGN
gene id: 9823:RGN
uniprot id: A0A4X1VIS8
uniprot id: F1RWY0
uniprot id: Q06AA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMP-30/CGR1 family.
messages: Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+).
messages: Cytoplasm
messages: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
messages: Monomer.

9823:TOP2A
gene id: 9823:TOP2A
uniprot id: A0A480JS00
uniprot id: O46374
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: Homodimer (By similarity). Interacts with COPS5 (By similarity). Interacts with RECQL5; this stimulates DNA decatenation (By similarity). Interacts with SETMAR; stimulates the topoisomerase activity (By similarity). Interacts with DHX9; this interaction occurs in a E2 enzyme UBE2I- and RNA-dependent manner, negatively regulates DHX9-mediated double-stranded DNA and RNA duplex helicase activity and stimulates TOP2A-mediated supercoiled DNA relaxation activity (By similarity). Interacts with HNRNPU (via C-terminus); this interaction protects the topoisomerase TOP2A from degradation and positively regulates the relaxation of supercoiled DNA in a RNA-dependent manner (By similarity). Interacts with MCM3AP (By similarity). Interacts with ERCC6 (By similarity). Interacts with PLSCR1 (By similarity). Interacts with GCNA; this interaction allows the resolution of topoisomerase II (TOP2A) DNA-protein cross-links (By similarity).
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (By similarity). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity).
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: Nucleus
messages: Phosphorylation has no effect on catalytic activity (By similarity). However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation (By similarity).
messages: nucleolus
messages: nucleoplasm

9823:RPL29
gene id: 9823:RPL29
uniprot id: Q95281
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL29 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:TLR1
gene id: 9823:TLR1
uniprot id: A0A4X1V574
uniprot id: Q4LDR7
uniprot id: Q59HI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9823:FOXP3
gene id: 9823:FOXP3
uniprot id: Q6BBQ1
names: Subcellular Location Annotation
messages: Nucleus

9823:SLC35C1
gene id: 9823:SLC35C1
uniprot id: A0A4X1SER9
uniprot id: A0A8D0X2S5
uniprot id: F1SHJ7
uniprot id: I3LB06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

9823:RNF111
gene id: 9823:RNF111
uniprot id: A0A480VLD1
uniprot id: A0A8D0J616
uniprot id: A0A8D1ASU5
uniprot id: A0A8D1C9T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

9823:POU2F2
gene id: 9823:POU2F2
uniprot id: Q29013
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Interacts with NR3C1, AR and PGR. Interacts with POU2AF1; the interaction increases POU2F2 transactivation activity.
messages: Nucleus
messages: Predominantly expressed in B-cells.
messages: Transactivation activity is enhanced by transcriptional coactivator POU2AF1.
messages: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates IL6 expression in B cells with POU2AF1. Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.

9823:CBLB
gene id: 9823:CBLB
uniprot id: A0A5K1V2H7
uniprot id: A0A8D0YK38
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9823:ELP5
gene id: 9823:ELP5
uniprot id: A0A4X1V0F4
uniprot id: I3LVM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9823:LOC100516628
gene id: 9823:LOC100516628
uniprot id: A0A480QK70
uniprot id: A0A8D1UHF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9823:LOC100621352
gene id: 9823:LOC100621352
uniprot id: A0A4X1VF46
uniprot id: I3L7J3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:TCEAL1
gene id: 9823:TCEAL1
uniprot id: A0A4X1UXL6
uniprot id: K7GS80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: Nucleus

9823:NOV
gene id: 9823:NOV
uniprot id: A0A481D0V4
uniprot id: A0A4X1T7A5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:RPS28
gene id: 9823:RPS28
uniprot id: Q6QAT1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9823:BSP1
gene id: 9823:BSP1
uniprot id: P80964
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the seminal plasma protein family.
messages: Component of seminal plasma.
messages: May form a complex with spermadhesin AQN-1 which possesses phosphorylcholine-binding activity.
messages: Secreted

9823:NCLN
gene id: 9823:NCLN
uniprot id: A0A481CWD2
uniprot id: A0A4X1VSQ7
uniprot id: A0A4X1VTC6
uniprot id: A0A8D1MY07
uniprot id: F1S8E9
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

9823:DDIT4
gene id: 9823:DDIT4
uniprot id: A0A287ABI0
uniprot id: A0A4X1T7U4
names: Similarity
messages: Belongs to the DDIT4 family.

9823:LGR6
gene id: 9823:LGR6
uniprot id: A0A287A200
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:B3GNT3
gene id: 9823:B3GNT3
uniprot id: A0A8D1NRV6
uniprot id: F1S937
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:COX7C
gene id: 9823:COX7C
uniprot id: Q1W0Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9823:CA5B
gene id: 9823:CA5B
uniprot id: A0A8D1CH84
uniprot id: F1SQS9
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9823:LOC100624207
gene id: 9823:LOC100624207
uniprot id: A0A8D0IIJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GPKOW
gene id: 9823:GPKOW
uniprot id: A0A4X1SXY6
uniprot id: F1RW48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus

9823:CHRM4
gene id: 9823:CHRM4
uniprot id: A0A8D1G6W5
uniprot id: F1SIA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9823:TWISTNB
gene id: 9823:TWISTNB
uniprot id: A0A480DRU8
uniprot id: A0A4X1TAK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: nucleolus

9823:CD79A
gene id: 9823:CD79A
uniprot id: A0A8D1QJ52
uniprot id: B5QTD1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:MSMB
gene id: 9823:MSMB
uniprot id: O02826
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the beta-microseminoprotein family.
messages: Corpora lutea, mostly in the luteal cells surrounding blood vessels.
messages: Homodimer; Interacts with PI16.
messages: Secreted
messages: Was originally thought to inhibit the secretion of FSH by pituitary cells.

9823:STARD6
gene id: 9823:STARD6
uniprot id: A0A4X1UGP3
uniprot id: F1S1Z6
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9823:LOC100518644
gene id: 9823:LOC100518644
uniprot id: A0A8D0IBQ8
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9823:MNS1
gene id: 9823:MNS1
uniprot id: A0A4X1TJ85
uniprot id: A0A5G2RCJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: Nucleus
messages: cilium axoneme
messages: flagellum axoneme

9823:FAM57A
gene id: 9823:FAM57A
uniprot id: A0A8D1PDB0
uniprot id: F1RHJ6
names: Subcellular Location Annotation
messages: Membrane

9823:MOS
gene id: 9823:MOS
uniprot id: P50118
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Restricted to gonadal tissues.

9823:KRT19
gene id: 9823:KRT19
uniprot id: A0A480J3V8
uniprot id: A0A8D1XKE4
names: Similarity
messages: Belongs to the intermediate filament family.

9823:SF3B4
gene id: 9823:SF3B4
uniprot id: A0A8D1J3P2
uniprot id: F1SDG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9823:MLN
gene id: 9823:MLN
uniprot id: A0A140TAJ7
uniprot id: A0A8D1NBV5
uniprot id: P01307
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

9823:KCNK13
gene id: 9823:KCNK13
uniprot id: A0A4X1SV13
uniprot id: F1SDA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:RPL6
gene id: 9823:RPL6
uniprot id: Q2YGT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL6 family.
messages: Component of the large ribosomal subunit (PubMed:24930395). May bind IPO9 with low affinity (By similarity).
messages: Component of the large ribosomal subunit (PubMed:24930395). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24930395).
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9823:MOSPD1
gene id: 9823:MOSPD1
uniprot id: A0A481C7E9
uniprot id: A0A4X1SEQ4
uniprot id: D3K5J0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

9823:ANXA9
gene id: 9823:ANXA9
uniprot id: A0A287AK76
uniprot id: A0A8D1ZM65
uniprot id: A0A8D1ZW40
uniprot id: F1SS97
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9823:ZNF232
gene id: 9823:ZNF232
uniprot id: A0A8D0R0N2
uniprot id: I3LGC5
names: Subcellular Location Annotation
messages: Nucleus

9823:TET1
gene id: 9823:TET1
uniprot id: A0A4X1TN68
uniprot id: M9T6D7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9823:MBTD1
gene id: 9823:MBTD1
uniprot id: A0A286ZRK9
uniprot id: A0A4X1VCS5
uniprot id: A0A8D1P9Q3
uniprot id: A0A8D1RJB9
names: Subcellular Location Annotation
messages: Nucleus

9823:GGH
gene id: 9823:GGH
uniprot id: A0A286ZMB2
uniprot id: A0A4X1V297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9823:C1GALT1
gene id: 9823:C1GALT1
uniprot id: A0A286ZJT7
uniprot id: A0A8D1ZA71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Membrane

9823:PSMD13
gene id: 9823:PSMD13
uniprot id: A0A4X1VZI2
uniprot id: F1RGC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9823:CCL5
gene id: 9823:CCL5
uniprot id: A0A4X1T3A0
uniprot id: Q2EN89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:FAAH
gene id: 9823:FAAH
uniprot id: A0A287B421
uniprot id: A0A8D1FAJ9
uniprot id: Q9TUI8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidase family.
messages: Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:10526230, PubMed:12664593). Also catalyzes the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:10526230, PubMed:12664593). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: inhibited by trifluoromethyl ketone.

9823:IFNGR1
gene id: 9823:IFNGR1
uniprot id: A0A8D1CBJ4
uniprot id: A0A8D1YDQ9
uniprot id: D5L0N8
uniprot id: F1S692
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9823:PELI3
gene id: 9823:PELI3
uniprot id: A0A480L492
uniprot id: A0A4X1TL40
uniprot id: A0A4X1TNC3
uniprot id: K7GS70
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9823:LOC100157391
gene id: 9823:LOC100157391
uniprot id: A0A286ZKA7
uniprot id: A0A4X1VE54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9823:QPRT
gene id: 9823:QPRT
uniprot id: I3LK75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

9823:ALDH1L2
gene id: 9823:ALDH1L2
uniprot id: A0A4X1T9B0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9823:RPL8
gene id: 9823:RPL8
uniprot id: A0A4X1UQ84
uniprot id: F2Z567
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9823:HAUS1
gene id: 9823:HAUS1
uniprot id: A0A8D1VE93
uniprot id: F1RPT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9823:GABARAPL2
gene id: 9823:GABARAPL2
uniprot id: A0A5G2QTL2
uniprot id: A0A8D0THN7
names: Similarity
messages: Belongs to the ATG8 family.

9823:CDS1
gene id: 9823:CDS1
uniprot id: Q30GF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9823:PNMT
gene id: 9823:PNMT
uniprot id: Q06AU9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
messages: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor. Other substrates include phenylethanolamine, octopamine and normetanephrine (By similarity).

9823:METTL15
gene id: 9823:METTL15
uniprot id: A0A8D2C5A4
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9823:LOC100736675
gene id: 9823:LOC100736675
uniprot id: A0A5G2QT77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SMAD9
gene id: 9823:SMAD9
uniprot id: A0A4X1T3U1
uniprot id: E1B2C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9823:CELF3
gene id: 9823:CELF3
uniprot id: A0A4X1W1H7
uniprot id: A0A8D1GTG1
uniprot id: F1ST15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9823:IHH
gene id: 9823:IHH
uniprot id: A0A4X1UI09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: Secreted
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9823:CD59
gene id: 9823:CD59
uniprot id: O62680
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in all tissues tested (lung, testis liver, kidney, spleen, heart and skeletal muscle). Highest levels in lung and spleen, lowest levels in liver and skeletal muscle.
messages: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.

9823:SHAS2
gene id: 9823:SHAS2
uniprot id: Q8SQ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

9823:DNAJC24
gene id: 9823:DNAJC24
uniprot id: A0A4X1SXG8
uniprot id: I3L880
names: Similarity
messages: Belongs to the DPH4 family.

9823:GUCY1A3
gene id: 9823:GUCY1A3
uniprot id: A0A4X1U2Q9
uniprot id: Q4ZHR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9823:SEC61A1
gene id: 9823:SEC61A1
uniprot id: A0A4X1TV07
uniprot id: I3LD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:SNRPD2
gene id: 9823:SNRPD2
uniprot id: A0A287BQU7
uniprot id: A0A4X1W115
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

9823:GC
gene id: 9823:GC
uniprot id: A0A4X1T9I2
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9823:VSX1
gene id: 9823:VSX1
uniprot id: A0A4X1V1M7
uniprot id: I3LGC8
names: Subcellular Location Annotation
messages: Nucleus

9823:CCDC85B
gene id: 9823:CCDC85B
uniprot id: A0A4X1UGE5
uniprot id: F1RU25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9823:EFTUD2
gene id: 9823:EFTUD2
uniprot id: A0A8D1WZ98
uniprot id: F1RQZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Nucleus

9823:LRP12
gene id: 9823:LRP12
uniprot id: A0A286ZXB4
uniprot id: A0A8D1ABC0
uniprot id: I7CEB2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:GLRB
gene id: 9823:GLRB
uniprot id: A0A4X1U664
uniprot id: Q6KBX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:HNRNPA2B1
gene id: 9823:HNRNPA2B1
uniprot id: A0A481CJY0
uniprot id: A0A4X1TY93
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

9823:AGO4
gene id: 9823:AGO4
uniprot id: D9YJ47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9823:A4GNT
gene id: 9823:A4GNT
uniprot id: A0A4X1TK07
uniprot id: I3LSM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9823:KEF22 p07
gene id: 9823:KEF22_p07
uniprot id: Q35916
uniprot id: Q69G29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9823:PTPRB
gene id: 9823:PTPRB
uniprot id: A0A4X1VW45
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9823:TESMIN
gene id: 9823:TESMIN
uniprot id: A0A4X1SNK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9823:CXCR3
gene id: 9823:CXCR3
uniprot id: A0A4X1W266
uniprot id: K7GML5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

9823:RIPPLY3
gene id: 9823:RIPPLY3
uniprot id: A0A8D1RU58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9823:PRAF2
gene id: 9823:PRAF2
uniprot id: A0A4X1T6F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9823:RHPN1
gene id: 9823:RHPN1
uniprot id: A0A8D1N134
uniprot id: F1SEV5
names: Similarity
messages: Belongs to the RHPN family.

9823:TMIGD3
gene id: 9823:TMIGD3
uniprot id: A0A287A3C0
uniprot id: A0A4X1T9V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:CYP3A29
gene id: 9823:CYP3A29
uniprot id: P79401
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

9823:ICOS
gene id: 9823:ICOS
uniprot id: A0A4X1V2P7
uniprot id: I3LV71
uniprot id: Q2KMN0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9823:NKRF
gene id: 9823:NKRF
uniprot id: A0A8D1L7Q1
uniprot id: F1RUA0
names: Similarity
messages: Belongs to the CARF family.

9823:TM6SF1
gene id: 9823:TM6SF1
uniprot id: A0A287BAJ7
uniprot id: A0A4X1ULT7
uniprot id: A0A4X1UP10
uniprot id: F1RIB3
names: Subcellular Location Annotation
messages: Membrane

9823:LAMP5
gene id: 9823:LAMP5
uniprot id: A0A8D1EKI5
uniprot id: F1SBK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9823:DDX55
gene id: 9823:DDX55
uniprot id: A0A287AP74
uniprot id: A0A4X1UKV9
uniprot id: A0A4X1ULL1
uniprot id: F1RFL5
names: Similarity
messages: Belongs to the DEAD box helicase family.

9823:TBK1
gene id: 9823:TBK1
uniprot id: A0A4X1W422
uniprot id: A7UNK0
names: Subcellular Location Annotation
messages: Cytoplasm

9823:SSRP1
gene id: 9823:SSRP1
uniprot id: A0A480V3H8
uniprot id: A0A4X1VPY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9823:MPP5
gene id: 9823:MPP5
uniprot id: A0A4X1UAE0
uniprot id: F1SA41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: tight junction

9823:LOC100513910
gene id: 9823:LOC100513910
uniprot id: A0A287A3R9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MAP7D1
gene id: 9823:MAP7D1
uniprot id: A0A480VWB2
uniprot id: A0A4X1VX10
uniprot id: A0A4X1VYT8
uniprot id: A0A8D1CM32
uniprot id: F1SV46
names: Similarity
messages: Belongs to the MAP7 family.

9823:ATP23
gene id: 9823:ATP23
uniprot id: A0A4X1VZJ5
uniprot id: F1SKD9
names: Similarity
messages: Belongs to the peptidase M76 family.

9823:SERPINB7
gene id: 9823:SERPINB7
uniprot id: A0A4X1TVC7
uniprot id: F1SMW6
names: Similarity
messages: Belongs to the serpin family.

9823:FAM118B
gene id: 9823:FAM118B
uniprot id: A0A480VBD4
uniprot id: A0A8D0RDS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

9823:CCND3
gene id: 9823:CCND3
uniprot id: Q007T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9823:PSEN2
gene id: 9823:PSEN2
uniprot id: Q0MS45
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase A22A family.
messages: Detected in the embryonic brain in frontal cortex (at protein level). Expressed in the developing brain: frontal cortex, cerebellum, hippocampus, basal ganglia and brain stem. Localized mainly in neuronal cells and astrocytes.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with DOCK3. Interacts with HERPUD1, FLNA, FLNB and PARL (By similarity).
messages: Phosphorylated on serine residues.
messages: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
messages: The PAL motif is required for normal active site conformation.

9823:MMGT1
gene id: 9823:MMGT1
uniprot id: A0A4X1SE98
uniprot id: F1RTC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

9823:NDUFC1
gene id: 9823:NDUFC1
uniprot id: A0A8D1AS36
uniprot id: A1XQS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:GPX5
gene id: 9823:GPX5
uniprot id: O18994
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutathione peroxidase family.
messages: Homotetramer.
messages: May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxides the protective effect is not likely to be exerted by its enzymatic activity. Instead, may protect sperm from premature acrosome reaction in the epididymis by binding to lipid peroxides, which might otherwise interact with phospholipase A2 and induce the acrosome reaction.
messages: Proximal caput epididymis.
messages: Secreted

9823:FOLR1
gene id: 9823:FOLR1
uniprot id: A0A287BLX2
uniprot id: A0A4X1UY18
uniprot id: A0A4X1V387
uniprot id: A0A8D1D1N2
uniprot id: Q9XSH0
uniprot id: Q9XSH1
names: Similarity
messages: Belongs to the folate receptor family.

9823:SPP2
gene id: 9823:SPP2
uniprot id: Q711S8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Multiply phosphorylated at serine residues.
messages: Phosphorylation sites are present in the extracellular medium.
messages: Secreted

9823:PCNA
gene id: 9823:PCNA
uniprot id: A0A4X1UCE6
uniprot id: X5FB24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9823:TRAF5
gene id: 9823:TRAF5
uniprot id: K7GN38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9823:CNN3
gene id: 9823:CNN3
uniprot id: A0A4X1TUU1
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9823:AGO3
gene id: 9823:AGO3
uniprot id: D9YJ46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9823:LOC100152013
gene id: 9823:LOC100152013
uniprot id: F1S3P9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:OAF
gene id: 9823:OAF
uniprot id: A0A481BCF8
uniprot id: A0A4X1VG34
names: Similarity
messages: Belongs to the OAF family.

9823:C5AR1
gene id: 9823:C5AR1
uniprot id: A0A4X1W0G9
uniprot id: A4UIZ2
uniprot id: I3LUE7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:CNTFR
gene id: 9823:CNTFR
uniprot id: A0A480KAN0
uniprot id: A0A4X1UV22
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9823:URAD
gene id: 9823:URAD
uniprot id: A0A8D1HKT1
uniprot id: F1RSV0
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9823:CPNE1
gene id: 9823:CPNE1
uniprot id: B8XSK0
names: Similarity
messages: Belongs to the copine family.

9823:GPD1L
gene id: 9823:GPD1L
uniprot id: A0A480JNF9
uniprot id: A0A4X1UFJ9
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9823:MAPRE1
gene id: 9823:MAPRE1
uniprot id: A0A4X1SZV0
uniprot id: Q2XVP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

9823:LOC100514282
gene id: 9823:LOC100514282
uniprot id: A0A286ZJ89
uniprot id: A0A4X1W6G6
names: Similarity
messages: Belongs to the PRORSD1 family.

9823:BARHL1
gene id: 9823:BARHL1
uniprot id: A0A4X1T443
uniprot id: F1S0T9
names: Subcellular Location Annotation
messages: Nucleus

9823:C12H17orf105
gene id: 9823:C12H17orf105
uniprot id: A0A4X1TT79
uniprot id: F1S1I7
names: Similarity
messages: Belongs to the CFAP97 family.

9823:ZFPL1
gene id: 9823:ZFPL1
uniprot id: A0A8D1KF42
uniprot id: F1RQT4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

9823:NAGK
gene id: 9823:NAGK
uniprot id: A0A480KE10
uniprot id: A0A4X1W9F7
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9823:ORM1
gene id: 9823:ORM1
uniprot id: A0A5G2R0I4
uniprot id: A0A8D0RQY2
uniprot id: A0A8D0RSL3
uniprot id: F1SN68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Functions as transport protein in the blood stream.
messages: Secreted

9823:TMEM88
gene id: 9823:TMEM88
uniprot id: A0A4X1V677
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9823:SLC5A7
gene id: 9823:SLC5A7
uniprot id: A0A4X1W1N8
uniprot id: F1SU25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9823:ISL1
gene id: 9823:ISL1
uniprot id: A0A4X1SR51
uniprot id: F1SMF7
names: Subcellular Location Annotation
messages: Nucleus

9823:CLGN
gene id: 9823:CLGN
uniprot id: A0A4X1VJ97
uniprot id: A0A8D0YFV6
uniprot id: I3LQ01
names: Similarity
messages: Belongs to the calreticulin family.

9823:B4GALT3
gene id: 9823:B4GALT3
uniprot id: A0A4X1VRJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9823:AP2S1
gene id: 9823:AP2S1
uniprot id: A0A287BIG4
uniprot id: A0A4X1W0P4
uniprot id: A0A4X1W204
uniprot id: I3LG98
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

9823:ACTB
gene id: 9823:ACTB
uniprot id: Q6QAQ1
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
messages: Belongs to the actin family.
messages: ISGylated.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-73 by SETD3 (By similarity). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).
messages: Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM (By similarity). Interacts with TBC1D21. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes. Interacts with FAM107A (By similarity).
messages: cytoskeleton

9823:MAPK1IP1L
gene id: 9823:MAPK1IP1L
uniprot id: A0A4X1WD38
uniprot id: F1SSP0
names: Similarity
messages: Belongs to the MISS family.

9823:TXNL4A
gene id: 9823:TXNL4A
uniprot id: A0A287A0V4
uniprot id: A0A4X1SCZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9823:MAPRE2
gene id: 9823:MAPRE2
uniprot id: A0A5G2QFP4
uniprot id: A0A8D0QTV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
messages: cytoskeleton

9823:CD3G
gene id: 9823:CD3G
uniprot id: Q5PXD3
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.
messages: Cell membrane
messages: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. Phosphorylated also by PKC; leading to the TCR complex down-regulation.
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9823:TRIM45
gene id: 9823:TRIM45
uniprot id: A0A8D1VNM6
uniprot id: K7GLN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9823:CHST1
gene id: 9823:CHST1
uniprot id: A0A4X1SF01
uniprot id: F1SHJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9823:SLC26A5
gene id: 9823:SLC26A5
uniprot id: A0A4X1VAZ2
uniprot id: B5TGG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ.

9823:MIEF1
gene id: 9823:MIEF1
uniprot id: A0A287ALN3
uniprot id: A0A4X1VWK8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9823:THOC6
gene id: 9823:THOC6
uniprot id: A0A286ZII9
uniprot id: A0A4X1VSU3
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9823:CYP11A1
gene id: 9823:CYP11A1
uniprot id: F1D8K7
uniprot id: P10612
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:1773895, PubMed:2039527). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:1773895, PubMed:2039527). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:1773895, PubMed:2039527).
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Interacts with FDX1/adrenodoxin.
messages: Mitochondrion inner membrane

9823:CHI3L1
gene id: 9823:CHI3L1
uniprot id: Q29411
names: Caution
names: Function
names: Induction
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity.
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity). Stimulates migration and adhesion of cultured vascular smooth muscle cells.
messages: Cytoplasm
messages: Detected in smooth muscle cells in atherosclerotic plaques. Detected in regions of vascular occlusion in the aorta.
messages: Endoplasmic reticulum
messages: Monomer.
messages: Sequencing errors.
messages: Up-regulated in cultured aortic smooth muscle cells upon transition to a nodular, multilayered culture.
messages: extracellular space
messages: perinuclear region

9823:APOO
gene id: 9823:APOO
uniprot id: A0A4X1VD16
uniprot id: K7GPW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9823:THBD
gene id: 9823:THBD
uniprot id: B3STX8
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

9823:MMP9
gene id: 9823:MMP9
uniprot id: Q2VI03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

9823:BTAF1
gene id: 9823:BTAF1
uniprot id: A0A287AFM0
uniprot id: A0A8D1NW12
names: Subcellular Location Annotation
messages: Nucleus

9823:TIMM44
gene id: 9823:TIMM44
uniprot id: A0A480JTC0
uniprot id: A0A8D0VD40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

9823:TOMM5
gene id: 9823:TOMM5
uniprot id: A0A4X1V5I3
uniprot id: F1ST72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:CCNL1
gene id: 9823:CCNL1
uniprot id: A0A4X1SJ67
uniprot id: I3LG02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

9823:VIPAS39
gene id: 9823:VIPAS39
uniprot id: A0A4X1T3Y7
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9823:MFRP
gene id: 9823:MFRP
uniprot id: A0A4X1SE15
uniprot id: F1SAF7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:HLCS
gene id: 9823:HLCS
uniprot id: A0A8D1MTH1
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9823:CCNG1
gene id: 9823:CCNG1
uniprot id: A0A480PKJ0
uniprot id: Q52QT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

9823:CAPZB
gene id: 9823:CAPZB
uniprot id: A0A8D1Q0S8
uniprot id: A9XFX6
uniprot id: D2JYW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

9823:PIH1D3
gene id: 9823:PIH1D3
uniprot id: A0A4X1VZI1
uniprot id: A0A8D0S7C3
uniprot id: K7GNQ8
names: Similarity
messages: Belongs to the PIH1 family.

9823:PAXBP1
gene id: 9823:PAXBP1
uniprot id: A0A8D0P6W3
uniprot id: F1SH07
names: Similarity
messages: Belongs to the GCF family.

9823:XCR1
gene id: 9823:XCR1
uniprot id: A0A4X1T9D5
uniprot id: Q75ZH8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:LOC100512977
gene id: 9823:LOC100512977
uniprot id: A0A8D0ZQ48
uniprot id: F1SV18
names: Similarity
messages: Belongs to the KDELC family.

9823:IDNK
gene id: 9823:IDNK
uniprot id: A0A287A2X5
uniprot id: A0A480WUS7
uniprot id: A0A4X1UVE7
uniprot id: A0A8D1AN46
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

9823:LOC100520823
gene id: 9823:LOC100520823
uniprot id: A0A5G2R8X1
uniprot id: A0A8D0YFB9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLC9A1
gene id: 9823:SLC9A1
uniprot id: P48762
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
messages: Membrane
messages: O-glycosylated.
messages: Oligomer (By similarity). Interacts with CALM in a calcium-dependent manner (By similarity). Interacts with TESC (By similarity). Interacts (via the juxtamembrane region of the cytoplasmic C-terminal domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner (By similarity). Interacts with CHP2; the interaction occurs in a calcium-dependent manner (By similarity).
messages: The interacting region with TESC is conflicting: In human, it has been reported that SLC9A1 interacts with TESC via the juxtamembrane region of the cytoplasmic C-terminal domain, including residues 503-545. However, another publication has reported interaction with TESC via residues 633-818, the region of the cytoplasmic C-terminus more distal to the membrane.
messages: The region between transmembrane regions M4 and M5 and between M6 and M7 (also termed intracellular loops IL2 and IL4, respectively) seem to be localized at least in part in the membrane. The hydrophobic region H10 is proposed to be located within the membrane.
messages: Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1 (By similarity).

9823:SGMS1
gene id: 9823:SGMS1
uniprot id: A0A4X1V2J2
uniprot id: A0AAS4
uniprot id: F1SCZ8
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sphingomyelin synthase family.
messages: Golgi apparatus membrane
messages: Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Does not use free phosphorylcholine or CDP-choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1.
messages: Membrane
messages: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.
messages: Widely expressed. Highest expression in the cardiovascular system.

9823:CYP4F2
gene id: 9823:CYP4F2
uniprot id: A0A287AAR2
uniprot id: A0A287B1Q2
uniprot id: A0A4X1VIQ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:CLNS1A
gene id: 9823:CLNS1A
uniprot id: A0A4X1UDW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9823:NXT1
gene id: 9823:NXT1
uniprot id: A0A4X1V0S0
uniprot id: F1SAT5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9823:DPYSL4
gene id: 9823:DPYSL4
uniprot id: A0A480URP4
uniprot id: A0A8D1V0Q8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9823:UBL3
gene id: 9823:UBL3
uniprot id: A0A287B7A4
uniprot id: A0A4X1TKE6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:LGR5
gene id: 9823:LGR5
uniprot id: A0A0H4J9E9
uniprot id: A0A4X1VVP4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SCGB1A1
gene id: 9823:SCGB1A1
uniprot id: A0A4X1VM49
uniprot id: F1RPX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9823:ATP9A
gene id: 9823:ATP9A
uniprot id: A5GFS1
uniprot id: K7GQ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9823:PEX2
gene id: 9823:PEX2
uniprot id: A0A480E925
uniprot id: A0A8D1I6B8
uniprot id: A0A8D1L0G1
uniprot id: F1RWL5
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9823:EIF1B
gene id: 9823:EIF1B
uniprot id: A0A480K792
uniprot id: P61220
names: Function
names: Similarity
messages: Belongs to the SUI1 family.
messages: Probably involved in translation.

9823:FAM98A
gene id: 9823:FAM98A
uniprot id: A0A8D0JIH5
uniprot id: F1S408
names: Similarity
messages: Belongs to the FAM98 family.

9823:LOC100152147
gene id: 9823:LOC100152147
uniprot id: A0A4X1SQ02
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FAM109B
gene id: 9823:FAM109B
uniprot id: A0A287BQ05
uniprot id: A0A8D0Z1Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9823:HEXB
gene id: 9823:HEXB
uniprot id: D0G6X8
uniprot id: Q29548
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Addition of GM2A stimulates the hydrolysis of sulfated glycosphingolipid SM2 and the ganglioside GM2.
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Cortical granule
messages: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity).
messages: Lysosome
messages: There are 3 forms of beta-hexosaminidase: hexosaminidase A is an heterodimer composed of one subunit alpha and one subunit beta (chain A and B); hexosaminidase B is an homodimer of two beta subunits (two chains A and B); hexosaminidase S is a homodimer of two alpha subunits (By similarity). The composition of the dimer (isozyme A versus isozyme S) has a significant effect on the substrate specificity of the alpha subunit active site (By similarity).

9823:SYK
gene id: 9823:SYK
uniprot id: Q00655
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region) to parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of the interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane proteins disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation. The phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially mediated by SRC subfamily kinases, like LYN, upon transmembrane receptors engagement (By similarity). May also be negatively regulated by PTPN6 through dephosphorylation (By similarity). Downstream signaling adapters and intermediates like BLNK or RHOH may mediate positive and/or negative feedback regulation (By similarity). Negatively regulated by CBL and CBLB through ubiquitination and probable degradation (By similarity). Phosphorylates SH3BP2 which in turn may regulate SYK through LYN.
messages: Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on Tyr-316 creates a binding site for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling. Phosphorylation at Tyr-341 creates a binding site for VAV1 (By similarity). Phosphorylation on Tyr-341 and Tyr-345 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3-kinase-independent pathway (By similarity). Phosphorylated on tyrosine residues in response to IL15 (By similarity). Phosphorylation on Ser-290 is very common, it peaks 5 minutes after BCR stimulation, and creates a binding site for YWHAG (By similarity). Phosphorylation at Tyr-623 creates a binding site for BLNK (By similarity). Dephosphorylated by PTPN6 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
messages: Cell membrane
messages: Interacts with LYN; phosphorylates SYK. Interacts with RHOH (phosphorylated); regulates mast cells activation (By similarity). Interacts with NFAM1 (phosphorylated); probably involved in BCR signaling (By similarity). Interacts with VAV1 (via SH2 domain); phosphorylates VAV1 upon BCR activation. Interacts with GAB2 (phosphorylated); probably involved in IgE Fc receptor signaling (By similarity). Interacts (via its SH2 domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation (By similarity). Interacts (via SH2 domains) with FCER1G (via ITAM domain); activates SYK and mediates neutrophils and macrophages integrin-mediated activation (By similarity). Interaction with FCER1G in basophils triggers IL3-induced IL4 production (By similarity). Interacts with ITGB2 and FGR; involved in ITGB2 downstream signaling (By similarity). Interacts with ITGB3; upon activation by ITGB3 promotes platelet adhesion (By similarity). Interacts (via SH2 domains) with TYROBP (via ITAM domain); involved in neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with MSN and SELPLG; mediates the selectin-dependent activation of SYK by SELPLG (By similarity). Interacts with BLNK (via SH2 domain) (By similarity). Interacts (via the second SH2 domain) with USP25 (via C-terminus); phosphorylates USP25 and regulates USP25 intracellular levels (By similarity). Interacts (via SH2 domains) with CLEC1B (dimer) (By similarity). Interacts with CLEC7A; participates in leukocyte activation in presence of fungal pathogens (By similarity). Interacts (phosphorylated) with SLA; may regulate SYK through CBL recruitment (By similarity). Interacts with YWHAG; attenuates BCR-induced membrane translocation and activation of SYK (By similarity). Interacts (via SH2 domains) with GCSAM; the interaction increases after B-cell receptor stimulation, resulting in enhanced SYK autophosphorylation and activity (By similarity).Inter…
messages: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activati…
messages: Shows high susceptibility to proteolysis.
messages: Spleen and with lesser amounts in thymus.
messages: The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The interaction with SYK requires CLEC1B homodimerization (By similarity).
messages: Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation.
messages: cytosol

9823:TYRO3
gene id: 9823:TYRO3
uniprot id: A0A4X1UYK4
uniprot id: A0A4X1UYL1
uniprot id: F1SSV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

9823:TMEM116
gene id: 9823:TMEM116
uniprot id: A0A287BB11
uniprot id: A0A4X1T9A0
uniprot id: A0A4X1TBM7
uniprot id: A0A8D0LZZ0
uniprot id: F1RJK9
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100511681
gene id: 9823:LOC100511681
uniprot id: A0A4X1TZJ8
uniprot id: F1S5T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CPLX1
gene id: 9823:CPLX1
uniprot id: A0A8D0LSF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9823:SUDS3
gene id: 9823:SUDS3
uniprot id: A0A8D1G881
names: Subcellular Location Annotation
messages: Nucleus

9823:SCT
gene id: 9823:SCT
uniprot id: P63298
names: Function
names: Pharmaceutical
names: Similarity
names: Subcellular Location Annotation
messages: Available under the name Secretin-Ferring (Ferring Pharmaceuticals). Used for diagnostic use in pancreatic dysfunction.
messages: Belongs to the glucagon family.
messages: Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity).
messages: Secreted

9823:CDK9
gene id: 9823:CDK9
uniprot id: A0A8D0S7Z0
uniprot id: C9E1C9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:LOC595122
gene id: 9823:LOC595122
uniprot id: A0A8D1ZVY7
uniprot id: Q53DY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9823:C12H17orf62
gene id: 9823:C12H17orf62
uniprot id: A0A4X1U432
uniprot id: F1S010
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:CAV3
gene id: 9823:CAV3
uniprot id: Q3ZDQ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Expressed specifically in skeletal muscle and heart.
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD. Interacts with TRIM72. Interacts with MUSK; may regulate MUSK signaling. Interacts with BVES. Interacts with CAVIN1, CAVIN2 and CAVIN4.
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.
messages: Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.
messages: caveola
messages: sarcolemma

9823:SEMA3E
gene id: 9823:SEMA3E
uniprot id: A0A8D0SUJ5
uniprot id: F1SBX2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CLVS2
gene id: 9823:CLVS2
uniprot id: A0A4X1TN77
uniprot id: F1S2T8
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9823:ZC3H12C
gene id: 9823:ZC3H12C
uniprot id: A0A287AVT6
uniprot id: A0A8D0JUR4
uniprot id: A0A8D0RZ43
uniprot id: A0A8D0Y0L5
uniprot id: A0A8D1YY14
uniprot id: F1SV13
names: Similarity
messages: Belongs to the ZC3H12 family.

9823:BCL9
gene id: 9823:BCL9
uniprot id: A0A480YSF0
uniprot id: A0A4X1SMU7
uniprot id: A0A8D0PGS9
uniprot id: F1SDC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9823:MEAF6
gene id: 9823:MEAF6
uniprot id: A0A481C504
uniprot id: A0A8D1WVQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

9823:GK
gene id: 9823:GK
uniprot id: A0A4X1VFA8
uniprot id: A0A8D1B697
uniprot id: A0A8D1IXK3
uniprot id: B8XSK5
uniprot id: K7GNE5
uniprot id: K7GRB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9823:FAM32A
gene id: 9823:FAM32A
uniprot id: A0A4X1UYF2
uniprot id: F1S9X7
names: Similarity
messages: Belongs to the FAM32 family.

9823:ITIH4
gene id: 9823:ITIH4
uniprot id: P79263
names: Function
names: Induction
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Appears to be both N- and O-glycosylated.
messages: Belongs to the ITIH family.
messages: Cleaved by plasma kallikrein to yield 55- and 25-kDa fragments.
messages: Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain).
messages: Levels increase significantly after cardiogenic shock. Specifically induced by the cytokine IL6 in hepatocytes.
messages: Liver specific.
messages: Secreted
messages: Sequencing errors.
messages: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.

9823:NEMP1
gene id: 9823:NEMP1
uniprot id: A0A8D1W5H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9823:ATE1
gene id: 9823:ATE1
uniprot id: A0A287BP37
uniprot id: A0A480M856
uniprot id: A0A5G2RH42
uniprot id: A0A8D0ZJW3
uniprot id: A0A8D0ZNV4
uniprot id: A0A8D1CSL7
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9823:DSG1
gene id: 9823:DSG1
uniprot id: Q3BDI7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to JUP/plakoglobin (By similarity). Interacts with PKP2 (By similarity).
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
messages: desmosome

9823:ADAM3A
gene id: 9823:ADAM3A
uniprot id: A5A4F6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MDFI
gene id: 9823:MDFI
uniprot id: A0A287B252
uniprot id: A0A480V2U7
uniprot id: A0A4X1SJK1
uniprot id: A0A8D1FIL7
uniprot id: F1RUY3
names: Similarity
messages: Belongs to the MDFI family.

9823:AP2B1
gene id: 9823:AP2B1
uniprot id: A0A480V1M7
uniprot id: A0A4X1T854
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9823:IL7R
gene id: 9823:IL7R
uniprot id: A0A8D1GNY7
uniprot id: B9ZSM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

9823:RPS27L
gene id: 9823:RPS27L
uniprot id: A0A4X1TYR3
uniprot id: F2Z5B7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9823:RBM4B
gene id: 9823:RBM4B
uniprot id: Q06AT9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TNPO3, which may mediate nuclear import of the protein.
messages: Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity).
messages: nucleolus

9823:ZIC1
gene id: 9823:ZIC1
uniprot id: A0A4X1T2L0
uniprot id: F1SKC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9823:INS
gene id: 9823:INS
uniprot id: P01315
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

9823:FUT11
gene id: 9823:FUT11
uniprot id: A0A287BIT3
uniprot id: A0A8D1H7C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9823:CCL28
gene id: 9823:CCL28
uniprot id: Q58NT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:CABIN1
gene id: 9823:CABIN1
uniprot id: A0A8D0SML0
uniprot id: F1RL39
names: Subcellular Location Annotation
messages: Nucleus

9823:IFN-ALPHA-4
gene id: 9823:IFN-ALPHA-4
uniprot id: A0A4X1WC24
uniprot id: C8CK95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:TNNI3
gene id: 9823:TNNI3
uniprot id: A5X497
names: Function
names: Similarity
messages: Belongs to the troponin I family.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9823:SUPV3L1
gene id: 9823:SUPV3L1
uniprot id: A0A480TMV4
uniprot id: A0A4X1TIG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9823:FAM151B
gene id: 9823:FAM151B
uniprot id: A0A4X1T6F7
uniprot id: I3LUI5
names: Similarity
messages: Belongs to the FAM151 family.

9823:ARPC4
gene id: 9823:ARPC4
uniprot id: A0A4X1USZ2
uniprot id: B5APU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9823:DCLK3
gene id: 9823:DCLK3
uniprot id: A0A4X1U1Z3
uniprot id: F1RRD2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9823:ASPN
gene id: 9823:ASPN
uniprot id: A0A4X1U1Q7
uniprot id: F1SUE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9823:MYH2
gene id: 9823:MYH2
uniprot id: Q9TV63
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction. Required for cytoskeleton organization (By similarity).
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with GCSAM.
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-2 (MYO2).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9823:AEBP1
gene id: 9823:AEBP1
uniprot id: A0A8D1PQV8
uniprot id: F1SSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9823:CYP27B1
gene id: 9823:CYP27B1
uniprot id: A0A8D0R998
uniprot id: Q9XS57
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:IMMP1L
gene id: 9823:IMMP1L
uniprot id: A0A287A8V6
uniprot id: A0A287AVY3
uniprot id: A0A4X1SX34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9823:MTFR1
gene id: 9823:MTFR1
uniprot id: A0A4X1UZU4
uniprot id: F1RTB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9823:NDUFB3
gene id: 9823:NDUFB3
uniprot id: A0A287AS93
uniprot id: A0A4X1VBN1
uniprot id: A0A4X1VD84
uniprot id: F1SI50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9823:IL23A
gene id: 9823:IL23A
uniprot id: C8KIR2
uniprot id: Q9N2H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. Interacts with IL23R; this interaction enables recruitment of IL12RB1.
messages: Secreted

9823:CWC15
gene id: 9823:CWC15
uniprot id: A0A480R8N2
uniprot id: A0A8D1N3E7
names: Similarity
messages: Belongs to the CWC15 family.

9823:PIGU
gene id: 9823:PIGU
uniprot id: A0A4X1T641
uniprot id: D0G6R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:SCAMP3
gene id: 9823:SCAMP3
uniprot id: A0A4X1W036
uniprot id: F1RLJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9823:HHIPL2
gene id: 9823:HHIPL2
uniprot id: A0A8D2A7Y5
uniprot id: F1S9I3
names: Similarity
messages: Belongs to the HHIP family.

9823:MTFR1L
gene id: 9823:MTFR1L
uniprot id: A0A480DGG1
uniprot id: A0A4X1VMJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9823:LOC106504899
gene id: 9823:LOC106504899
uniprot id: A0A5G2QWZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:EN2
gene id: 9823:EN2
uniprot id: A0A287AUN5
uniprot id: A0A8D1UFJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

9823:BEX1
gene id: 9823:BEX1
uniprot id: A0A4X1V0M4
uniprot id: F1RYE5
names: Similarity
messages: Belongs to the BEX family.

9823:NAB2
gene id: 9823:NAB2
uniprot id: A0A8D0PXE4
uniprot id: I6L5G0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9823:GALM
gene id: 9823:GALM
uniprot id: A0A480TQM9
uniprot id: Q9GKX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Cytoplasm
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.

9823:UBALD2
gene id: 9823:UBALD2
uniprot id: A0A4X1UY87
uniprot id: A0A8D0UTP0
uniprot id: I3LEC8
names: Similarity
messages: Belongs to the UBALD family.

9823:UTP18
gene id: 9823:UTP18
uniprot id: A0A8D1REA8
uniprot id: F1RSH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

9823:PRDX2
gene id: 9823:PRDX2
uniprot id: A0A287BAZ6
uniprot id: A0A4X1TJM1
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9823:TWSG1
gene id: 9823:TWSG1
uniprot id: A0A480DUX8
uniprot id: A0A8D2CAQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

9823:DNASE1L1
gene id: 9823:DNASE1L1
uniprot id: Q2QDF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Endoplasmic reticulum

9823:IDO1
gene id: 9823:IDO1
uniprot id: F6K2E8
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9823:THOC7
gene id: 9823:THOC7
uniprot id: A0A4X1VF70
uniprot id: F1SGF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

9823:FGF21
gene id: 9823:FGF21
uniprot id: A0A8D1S7X8
uniprot id: C6JWG4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:LOC100517830
gene id: 9823:LOC100517830
uniprot id: A0A287BP72
names: Similarity
messages: Belongs to the PRAME family.

9823:SFXN4
gene id: 9823:SFXN4
uniprot id: A0A286ZKL2
uniprot id: A0A4X1SX31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9823:MSMP
gene id: 9823:MSMP
uniprot id: A0A287AJ94
uniprot id: A0A4X1VW50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9823:PUS7L
gene id: 9823:PUS7L
uniprot id: A0A8D1PN70
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9823:SPATA6
gene id: 9823:SPATA6
uniprot id: A0A4X1W4Z6
uniprot id: D5K8A1
names: Similarity
messages: Belongs to the SPATA6 family.

9823:KRT35
gene id: 9823:KRT35
uniprot id: A0A8D1J8J6
uniprot id: F1S0K7
names: Similarity
messages: Belongs to the intermediate filament family.

9823:LYPD6
gene id: 9823:LYPD6
uniprot id: A0A4X1TI34
uniprot id: I3LF69
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SLC5A10
gene id: 9823:SLC5A10
uniprot id: Q5FY69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.

9823:ATP6V1E1
gene id: 9823:ATP6V1E1
uniprot id: A0A4X1UEG2
uniprot id: K9J4U3
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9823:BCAP31
gene id: 9823:BCAP31
uniprot id: A0A4X1T1G4
uniprot id: F1S2A8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9823:LEF1
gene id: 9823:LEF1
uniprot id: A0A287BMW2
uniprot id: A0A4X1UVU7
uniprot id: A0A4X1UVV8
uniprot id: A0A4X1UVW8
uniprot id: B3GQS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9823:GINS1
gene id: 9823:GINS1
uniprot id: A0A286ZXR4
uniprot id: A0A4X1V6Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9823:BSG
gene id: 9823:BSG
uniprot id: A0A4X1VQ17
uniprot id: B0LY42
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lateral cell membrane

9823:SLC22A8
gene id: 9823:SLC22A8
uniprot id: Q70BM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Expressed in kidney.
messages: Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (By similarity). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (Probable). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:15820748). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule. May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside. May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (By similarity). May contribute to the release of cortisol in the adrenals (By similarity). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (By similarity). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin…

9823:TNFSF14
gene id: 9823:TNFSF14
uniprot id: A0A287A9X9
uniprot id: A0A4X1VSJ9
uniprot id: A0A5G2QPS6
uniprot id: A0A8D1V6R8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:RFLNB
gene id: 9823:RFLNB
uniprot id: A0A287AN30
uniprot id: A0A8D1IKY4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9823:TPH1
gene id: 9823:TPH1
uniprot id: A0A480DFA6
uniprot id: A0A4X1TAT8
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9823:RPSA
gene id: 9823:RPSA
uniprot id: A0A480SME4
uniprot id: Q4GWZ2
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9823:GAL3ST4
gene id: 9823:GAL3ST4
uniprot id: A0A8D1ZRT4
uniprot id: F1RNN6
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9823:NIFK
gene id: 9823:NIFK
uniprot id: A7E1T9
names: Subcellular Location Annotation
messages: nucleolus

9823:DEFB114
gene id: 9823:DEFB114
uniprot id: A0A4X1UZZ9
uniprot id: Q1RLJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:FGFR1OP2
gene id: 9823:FGFR1OP2
uniprot id: A0A4X1VJ49
uniprot id: A0A4X1VKS0
uniprot id: F1SG78
uniprot id: I3LNP7
names: Similarity
messages: Belongs to the SIKE family.

9823:EDNRA
gene id: 9823:EDNRA
uniprot id: Q29010
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).

9823:NSDHL
gene id: 9823:NSDHL
uniprot id: A0A4X1TG22
uniprot id: D0G782
uniprot id: F1S2D0
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9823:PTS
gene id: 9823:PTS
uniprot id: A0A4X1TBY4
uniprot id: F1SM93
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9823:MED18
gene id: 9823:MED18
uniprot id: A0A4X1TLN3
uniprot id: I3LR60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:FGF18
gene id: 9823:FGF18
uniprot id: A0A4X1U5Q8
uniprot id: A0A5G2QUY7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:LOC100516987
gene id: 9823:LOC100516987
uniprot id: A0A287BF74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GNPDA2
gene id: 9823:GNPDA2
uniprot id: A0A4X1UI84
uniprot id: A0A8D1NEL2
uniprot id: F1S3T0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9823:HADH
gene id: 9823:HADH
uniprot id: A0A480WX09
uniprot id: P00348
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Homodimer (PubMed:3479790, PubMed:9593854). Interacts with GLUD1; this interaction inhibits the activation of glutamate dehydrogenase 1 (GLUD1) (By similarity).
messages: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:9593854, PubMed:2817332). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity).
messages: Mitochondrion matrix
messages: Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5.

9823:KCNJ14
gene id: 9823:KCNJ14
uniprot id: A0A4X1W044
uniprot id: F1RL84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9823:FAM187B
gene id: 9823:FAM187B
uniprot id: A0A8D1JSY3
uniprot id: I3LSC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9823:LOC100525119
gene id: 9823:LOC100525119
uniprot id: A0A4X1VIM1
uniprot id: F1S9N3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TRIM36
gene id: 9823:TRIM36
uniprot id: A0A480URD1
uniprot id: A0A4X1U0J5
uniprot id: A0A8D1L2H5
uniprot id: F1RLE9
names: Subcellular Location Annotation
messages: cytoskeleton

9823:HSBP1
gene id: 9823:HSBP1
uniprot id: A1XQV7
names: Similarity
messages: Belongs to the HSBP1 family.

9823:LAMTOR3
gene id: 9823:LAMTOR3
uniprot id: A0A4X1UJ60
uniprot id: F2Z5B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9823:RGS16
gene id: 9823:RGS16
uniprot id: F1S668
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Gets inactivated and/or degraded by porcine circovirus 2 ORF3 protein, leading to enhanced expression of IL-6 and IL-8 in infected lymphocytes. This would explain chronic inflammatory response of PCV2 infected pigs.
messages: (Microbial infection) Interacts with porcine circovirus 2 ORF3 protein.
messages: Interacts with GNAI1 and GNAQ. Interacts with GNAI3, GNAI3 and GNAO1.
messages: Membrane
messages: Palmitoylated on Cys-2 and/or Cys-12.
messages: Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1.
messages: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals.

9823:LOC100154873
gene id: 9823:LOC100154873
uniprot id: A0A4X1UA73
uniprot id: F1RXC2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9823:RLN2
gene id: 9823:RLN2
uniprot id: P01348
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
messages: Secreted

9823:TNIP2
gene id: 9823:TNIP2
uniprot id: A0A4X1SXK0
uniprot id: F1S8Q0
names: Subcellular Location Annotation
messages: Cytoplasm

9823:GOLPH3L
gene id: 9823:GOLPH3L
uniprot id: A0A287A0S1
uniprot id: A0A8D1FRE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9823:TPP1
gene id: 9823:TPP1
uniprot id: A0A8D1R6C0
uniprot id: I3L812
names: Cofactor
messages: Binds 1 Ca(2+) ion per subunit.

9823:RORC
gene id: 9823:RORC
uniprot id: A0A286ZPP7
uniprot id: A0A8D0Q7K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:PLPBP
gene id: 9823:PLPBP
uniprot id: A0A8D0ZN99
uniprot id: F1RX84
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9823:TPO
gene id: 9823:TPO
uniprot id: D6NHN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Interacts with DUOX1, DUOX2 and CYBA.
messages: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:PNO1
gene id: 9823:PNO1
uniprot id: A0A287B6J3
uniprot id: A0A4X1WAG7
names: Similarity
messages: Belongs to the PNO1 family.

9823:PFKM
gene id: 9823:PFKM
uniprot id: Q2HYU2
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: GlcNAcylation decreases enzyme activity.
messages: Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (M), PFKL (L) and PFKP (P). The composition of the PFK tetramer differs according to the tissue type it is present in. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable). Interacts (via C-terminus) with HK1 (via N-terminal spermatogenic cell-specific region) (By similarity).

9823:MRPS7
gene id: 9823:MRPS7
uniprot id: A0A286ZJ25
uniprot id: A0A4X1V4T6
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9823:LOC100520723
gene id: 9823:LOC100520723
uniprot id: A0A5G2R7L8
uniprot id: A0A8D1XVD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CTSV
gene id: 9823:CTSV
uniprot id: Q28944
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Dimer of a heavy and a light chain linked by disulfide bonds. Interacts with Long isoform of CD74/Ii chain; the interaction stabilizes the conformation of mature CTSL.
messages: During export along the endocytic pathway, pro-CTSL undergoes several proteolytic cleavages to generate the CTSL single-chain and two-chain mature forms, composed of a heavy chain linked to a light chain by disulfide bonds (By similarity). Autocleavage; produces the single-chain CTSL after cleavage of the propeptide. The cleavage can be intermolecular (By similarity).
messages: Inhibited by the propeptide produced by autocleavage (By similarity). Long isoform of CD74/Ii chain stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of APCs. IFNG enhances the conversion into the CTSL mature and active form (By similarity). Inhibited by CST6. Inhibited by the glycopeptide antibiotic teicoplanin. Inhibited by amantadine (By similarity).
messages: Lysosome
messages: Secreted
messages: Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity).
messages: chromaffin granule
messages: extracellular space

9823:AQP2
gene id: 9823:AQP2
uniprot id: A0A8D0I9I9
uniprot id: I3LH92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:GINS4
gene id: 9823:GINS4
uniprot id: A0A480XGX2
uniprot id: A0A8D1PZG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9823:TENM1
gene id: 9823:TENM1
uniprot id: A0A4X1W6Y0
uniprot id: F1RU60
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:CAPN5
gene id: 9823:CAPN5
uniprot id: A0A8D1ZTX6
names: Similarity
messages: Belongs to the peptidase C2 family.

9823:GFM2
gene id: 9823:GFM2
uniprot id: A0A287BK99
uniprot id: A0A4X1SNY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9823:LOC100156127
gene id: 9823:LOC100156127
uniprot id: A0A4X1VJJ6
uniprot id: F2Z584
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:VPS51
gene id: 9823:VPS51
uniprot id: A0A287AGP8
uniprot id: A0A4X1UYP1
uniprot id: A0A8D1HXJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Recycling endosome
messages: trans-Golgi network

9823:SLBP
gene id: 9823:SLBP
uniprot id: A0A4X1T2Q7
uniprot id: F1S9F2
names: Similarity
messages: Belongs to the SLBP family.

9823:INHBC
gene id: 9823:INHBC
uniprot id: A0A8D0JIV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9823:LOC100621552
gene id: 9823:LOC100621552
uniprot id: A0A287BDG3
uniprot id: A0A8D1Z9V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ATG4D
gene id: 9823:ATG4D
uniprot id: A0A286ZXV6
uniprot id: A0A8D1S2M5
uniprot id: A0A8D2ADC4
uniprot id: Q684M2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondrial import of the protein.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (By similarity). ATG4D plays a role in the autophagy-mediated neuronal homeostasis in the central nervous system. Compared to other members of the family (ATG4A, ATG4B or ATG4C), constitutes the major protein for the delipidation activity, while it promotes weak proteolytic activation of ATG8 proteins (By similarity). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (By similarity).
messages: Cytoplasm
messages: Inhibited by N-ethylmaleimide.
messages: Mitochondrion matrix
messages: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
messages: The cryptic mitochondrial transit peptide is revealed after cleavage by caspase upon oxidative stress and cell death. It acts then as a functional transit peptide, and allows the import of the cleaved protein into the mitochondria.

9823:DCAF11
gene id: 9823:DCAF11
uniprot id: A0A287B2N4
uniprot id: A0A4X1SM17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9823:HNRNPC
gene id: 9823:HNRNPC
uniprot id: A0A287AA79
uniprot id: A0A4X1UWE9
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9823:HMGCS1
gene id: 9823:HMGCS1
uniprot id: A0A5K1UCS8
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9823:TMCO3
gene id: 9823:TMCO3
uniprot id: A0A480YU12
uniprot id: A0A4X1TWC5
uniprot id: F1RN34
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100154044
gene id: 9823:LOC100154044
uniprot id: A0A287AW74
uniprot id: A0A4X1SF77
names: Similarity
messages: Belongs to the Bcl-2 family.

9823:ITM2C
gene id: 9823:ITM2C
uniprot id: Q06AV4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITM2 family.
messages: Cell membrane
messages: Interacts with BACE1. Interacts with APP. Interacts with STMN2 (By similarity).
messages: Lysosome membrane
messages: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
messages: Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B (By similarity).

9823:IFN-ALPHA-14
gene id: 9823:IFN-ALPHA-14
uniprot id: C8CKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:EVX1
gene id: 9823:EVX1
uniprot id: A0A4X1TSU9
uniprot id: F1SHT9
names: Subcellular Location Annotation
messages: Nucleus

9823:EME1
gene id: 9823:EME1
uniprot id: A0A4X1TVB1
uniprot id: F1RT80
names: Similarity
messages: Belongs to the EME1/MMS4 family.

9823:IK
gene id: 9823:IK
uniprot id: A0A8D0IN63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9823:BMP10
gene id: 9823:BMP10
uniprot id: A0A287A7C6
uniprot id: A0A4X1W9X6
names: Similarity
messages: Belongs to the TGF-beta family.

9823:HOXA11
gene id: 9823:HOXA11
uniprot id: A0A8D0NE02
uniprot id: F1SHT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9823:XKR9
gene id: 9823:XKR9
uniprot id: A0A8D1RUM0
uniprot id: F1RU13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9823:ARMCX3
gene id: 9823:ARMCX3
uniprot id: A0A287BGW5
uniprot id: A0A4X1VZ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9823:FRZB
gene id: 9823:FRZB
uniprot id: A0A4X1SQG3
uniprot id: S5Y9V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9823:LOC100515857
gene id: 9823:LOC100515857
uniprot id: A0A4X1T5L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:CUL4A
gene id: 9823:CUL4A
uniprot id: A0A480LCF6
uniprot id: A0A4X1U051
names: Similarity
messages: Belongs to the cullin family.

9823:GNRHR
gene id: 9823:GNRHR
uniprot id: P49922
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Pituitary gland.
messages: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

9823:HMGA1
gene id: 9823:HMGA1
uniprot id: A0A4X1T5Y2
uniprot id: B6CVL5
uniprot id: D5KJI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMGA family.
messages: Chromosome
messages: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
messages: Interacts with HIPK2.
messages: Nucleus

9823:MYCBP
gene id: 9823:MYCBP
uniprot id: A0A5G2Q9H8
uniprot id: A0A8D1GIK9
uniprot id: A0A8D1WCH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

9823:RPL10
gene id: 9823:RPL10
uniprot id: Q29195
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
messages: Ufmylated by UFL1.

9823:MED6
gene id: 9823:MED6
uniprot id: A0A480RAM0
uniprot id: A0A4X1U3D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9823:CCT6A
gene id: 9823:CCT6A
uniprot id: A0A8D1DI00
uniprot id: I3L9J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9823:MAOB
gene id: 9823:MAOB
uniprot id: A0A4X1VJA2
uniprot id: Q6PLK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

9823:NUPR2
gene id: 9823:NUPR2
uniprot id: A0A4X1T0T0
names: Similarity
messages: Belongs to the NUPR family.

9823:NEURL2
gene id: 9823:NEURL2
uniprot id: A0A4X1U106
uniprot id: F1SC72
names: Subcellular Location Annotation
messages: Cytoplasm

9823:POLR2J
gene id: 9823:POLR2J
uniprot id: A0A4X1UK25
uniprot id: F1RKE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9823:POLR3D
gene id: 9823:POLR3D
uniprot id: A0A4X1VG16
uniprot id: F1RMB0
names: Subcellular Location Annotation
messages: Nucleus

9823:NDUFV3
gene id: 9823:NDUFV3
uniprot id: A0A480JTE4
uniprot id: A0A4X1TE42
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

9823:TIMM17B
gene id: 9823:TIMM17B
uniprot id: A0A8D0JTS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

9823:ANXA13
gene id: 9823:ANXA13
uniprot id: A0A8D1HLV4
uniprot id: F1RRP6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9823:CCDC167
gene id: 9823:CCDC167
uniprot id: A0A287AUD4
uniprot id: A0A4X1SRW8
names: Subcellular Location Annotation
messages: Membrane

9823:DTX3
gene id: 9823:DTX3
uniprot id: A0A4X1W5X4
uniprot id: A0A8D1VPD2
uniprot id: I3LJN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9823:CXCL9
gene id: 9823:CXCL9
uniprot id: A0A4X1SX95
uniprot id: B0FYK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9823:LOC100739396
gene id: 9823:LOC100739396
uniprot id: A0A4X1VDT0
uniprot id: F1RSF6
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9823:PDLIM1
gene id: 9823:PDLIM1
uniprot id: A0A5K1TZ27
uniprot id: A0A8D1KGW9
names: Subcellular Location Annotation
messages: Z line

9823:LAMP3
gene id: 9823:LAMP3
uniprot id: A0A287BFU9
uniprot id: A0A480SDB7
uniprot id: A0A8D0RWP6
uniprot id: A0A8D0S198
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9823:TP63
gene id: 9823:TP63
uniprot id: A0A4X1UD57
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9823:FGF9
gene id: 9823:FGF9
uniprot id: Q95L12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity).
messages: Secreted

9823:NCSTN
gene id: 9823:NCSTN
uniprot id: A0A286ZSI3
uniprot id: A0A8D0IJB0
uniprot id: A0A8D1I1Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9823:ORMDL2
gene id: 9823:ORMDL2
uniprot id: A0A4X1W415
uniprot id: F1SPJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9823:SFXN5
gene id: 9823:SFXN5
uniprot id: A0A4X1W8A9
uniprot id: F1SLF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9823:TMC3
gene id: 9823:TMC3
uniprot id: F1RID4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9823:FUS
gene id: 9823:FUS
uniprot id: A0A4X1TF04
uniprot id: G8ENL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9823:LOC100520680
gene id: 9823:LOC100520680
uniprot id: A0A8D1G4W6
uniprot id: F1RUL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9823:HINT1
gene id: 9823:HINT1
uniprot id: A0A8D1MK00
uniprot id: F1RKI3
names: Similarity
messages: Belongs to the HINT family.

9823:CPEB4
gene id: 9823:CPEB4
uniprot id: A0A286ZUJ5
uniprot id: A0A287BFV6
uniprot id: A0A4X1U944
uniprot id: A0A4X1UDC8
uniprot id: A0A4X1UE07
uniprot id: A0A4X1UEL5
uniprot id: A0A8D0IGI7
names: Similarity
messages: Belongs to the RRM CPEB family.

9823:CKS1B
gene id: 9823:CKS1B
uniprot id: A0A480C3W8
uniprot id: A0A4X1W0Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9823:P3H3
gene id: 9823:P3H3
uniprot id: F1SLU9
names: Similarity
messages: Belongs to the leprecan family.

9823:MED29
gene id: 9823:MED29
uniprot id: A0A4X1SY16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9823:RPS7
gene id: 9823:RPS7
uniprot id: A0A287A9Y6
uniprot id: A0A4X1UGT6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

9823:PIANP
gene id: 9823:PIANP
uniprot id: A0A4X1UXH6
uniprot id: F1SLT0
names: Subcellular Location Annotation
messages: Membrane

9823:IFI35
gene id: 9823:IFI35
uniprot id: A0A4X1TWY6
uniprot id: I3LGI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9823:SELENOP
gene id: 9823:SELENOP
uniprot id: A1E951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein P family.
messages: Secreted

9823:VPS37B
gene id: 9823:VPS37B
uniprot id: A0A4X1UFQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9823:EHF
gene id: 9823:EHF
uniprot id: A0A4X1SQF9
uniprot id: A0A5G2QZR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:ADAMTS15
gene id: 9823:ADAMTS15
uniprot id: A0A8D1BAY0
uniprot id: F1S6D2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:SNCG
gene id: 9823:SNCG
uniprot id: A0A8D0N819
uniprot id: A7YX24
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

9823:CXCL2
gene id: 9823:CXCL2
uniprot id: A0A4X1T3L2
uniprot id: Q6PUJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9823:NRG4
gene id: 9823:NRG4
uniprot id: A0A4X1TYN8
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:SFT2D3
gene id: 9823:SFT2D3
uniprot id: F1RQI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9823:RBBP8
gene id: 9823:RBBP8
uniprot id: A0A4X1VMH3
uniprot id: I3L8X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

9823:PTH
gene id: 9823:PTH
uniprot id: P01269
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
messages: Secreted

9823:COX6A1
gene id: 9823:COX6A1
uniprot id: A0A287BGN0
uniprot id: A0A8D1LI22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9823:PGD
gene id: 9823:PGD
uniprot id: A0A480YSA5
uniprot id: A0A4X1W9L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9823:GDAP1
gene id: 9823:GDAP1
uniprot id: A0A4X1UKQ1
uniprot id: F1RWK1
names: Similarity
messages: Belongs to the GST superfamily.

9823:ANKS1A
gene id: 9823:ANKS1A
uniprot id: F8SIP9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9823:RTFDC1
gene id: 9823:RTFDC1
uniprot id: A0A4X1UPR2
uniprot id: A0A5S8KIH0
uniprot id: A5GFW7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rtf2 family.
messages: Chromosome
messages: Interacts with DDI2; probably also interacts with DDI1.
messages: Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.
messages: Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability.

9823:STAG2
gene id: 9823:STAG2
uniprot id: A0A286ZJX5
uniprot id: A0A4X1W6T1
uniprot id: A0A4X1W7Y7
uniprot id: A0A5K1UGR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9823:TMBIM6
gene id: 9823:TMBIM6
uniprot id: Q66RM2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BI1 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with BCL2. Interacts with BCL2L1.
messages: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation.
messages: The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol.

9823:SCARB2
gene id: 9823:SCARB2
uniprot id: A0A480ITG5
uniprot id: A0A4X1SYC5
uniprot id: A0A8D1FUA6
uniprot id: F1RYT3
names: Similarity
messages: Belongs to the CD36 family.

9823:MANBA
gene id: 9823:MANBA
uniprot id: A0A8D0KDM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9823:RNASE1
gene id: 9823:RNASE1
uniprot id: A0A8D1GIQ4
uniprot id: D0PSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9823:TMEM206
gene id: 9823:TMEM206
uniprot id: A0A4X1TM74
uniprot id: F1S2V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9823:ADAM17
gene id: 9823:ADAM17
uniprot id: A0A8D0LFA7
uniprot id: A5A749
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:VEZT
gene id: 9823:VEZT
uniprot id: A0A480VKQ5
uniprot id: A0A4X1SH23
uniprot id: A0A8D1G8R2
uniprot id: F1SQP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9823:MX1
gene id: 9823:MX1
uniprot id: P27594
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By type I and type III interferons.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).
messages: ISGylated.
messages: Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles.
messages: The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
messages: The middle domain mediates self-assembly and oligomerization.
messages: perinuclear region

9823:ZC3H15
gene id: 9823:ZC3H15
uniprot id: A0A4X1TY43
uniprot id: F1RYJ5
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9823:INTS8
gene id: 9823:INTS8
uniprot id: A0A8D1XXY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9823:CD164
gene id: 9823:CD164
uniprot id: A0A4X1VE80
uniprot id: K9IVV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9823:CATSPERE
gene id: 9823:CATSPERE
uniprot id: A0A4X1T3V8
uniprot id: A0A5G2QKE1
names: Similarity
messages: Belongs to the CATSPERD family.

9823:BRINP3
gene id: 9823:BRINP3
uniprot id: A0A4X1TV71
uniprot id: F1SA93
names: Similarity
messages: Belongs to the BRINP family.

9823:TGFBR1
gene id: 9823:TGFBR1
uniprot id: A0A8D0NQ10
uniprot id: Q19ML6
uniprot id: Q5CD18
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Cell surface
messages: Homodimer; in the endoplasmic reticulum but also at the cell membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with CD109; inhibits TGF-beta receptor activation in keratinocytes. Interacts with RBPMS. Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation. Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with TRAF6 and MAP3K7; induces MAP3K7 activation by TRAF6. Interacts with PARD6A; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1 and SMURF2 to the TGF-beta receptor (By similarity). Interacts with USP15 and VPS39. Interacts with SDCBP (via C-terminus). Interacts with CAV1 and this interaction is impaired in the presence of SDCBP (By similarity). Interacts with APPL1; interaction is TGF beta dependent; mediates trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (By similarity).
messages: Kept in an inactive conformation by FKBP1A preventing receptor activation in absence of ligand. CD109 is another inhibitor of the receptor (By similarity).
messages: May be due to a competing donor splice site.
messages: Membrane
messages: Membrane raft
messages: N-Glycosylated.
messages: Phosphorylated at basal levels in the absence of ligand. Activated upon phosphorylation by TGFBR2, mainly in the GS domain. Phosphorylation in the GS domain abrogates FKBP1A-binding (By similarity).
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity).
messages: Ubiquitinated; undergoes ubiquitination catalyzed by several E3 ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results in the proteasomal and/or lysosomal degradation of the receptor thereby negatively regulating its activity. Deubiquitinated by USP15, leading to stabilization of the protein and enhanced TGF-beta signal. Its ubiquitination and proteasome-mediated degradation is negatively regulated by SDCBP (By similarity).
messages: tight junction

9823:GRHL2
gene id: 9823:GRHL2
uniprot id: A0A8D1BQM0
names: Subcellular Location Annotation
messages: Nucleus

9823:POU4F2
gene id: 9823:POU4F2
uniprot id: A0A4X1SGW6
uniprot id: I3L5L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9823:POU4F3
gene id: 9823:POU4F3
uniprot id: A0A8D0S532
uniprot id: F1RM14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9823:IFNG
gene id: 9823:IFNG
uniprot id: A9LN08
uniprot id: P17803
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Released primarily from activated T lymphocytes.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9823:LOC100524613
gene id: 9823:LOC100524613
uniprot id: A0A4X1V0F2
names: Similarity
messages: Belongs to the peptidase M16 family.

9823:CAND1
gene id: 9823:CAND1
uniprot id: A0A480K0D5
uniprot id: A0A8D0WBN9
names: Similarity
messages: Belongs to the CAND family.

9823:TMEM151B
gene id: 9823:TMEM151B
uniprot id: A0A286ZL63
uniprot id: A0A4X1V5T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9823:DHPS
gene id: 9823:DHPS
uniprot id: A0A4X1UEF2
uniprot id: F1SEX8
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

9823:SLC22A12
gene id: 9823:SLC22A12
uniprot id: A0A4X1VBJ4
uniprot id: A0A8D0VQK0
names: Subcellular Location Annotation
messages: Membrane

9823:PPARGC1A
gene id: 9823:PPARGC1A
uniprot id: Q865B6
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Heavily acetylated by KAT2A/GCN5 under conditions of high nutrients, leading to inactivation of PPARGC1A. Deacetylated by SIRT1 in low nutrients/high NAD conditions, leading to its activation.
messages: Homooligomer (By similarity). Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (By similarity). Interacts with LRPPRC (By similarity). Interacts with FOXO1 (By similarity).
messages: Nucleus
messages: PML body
messages: Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.
messages: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (By similarity). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity).
messages: Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.

9823:MAL2
gene id: 9823:MAL2
uniprot id: A0A4X1T956
uniprot id: C3UP60
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100155213
gene id: 9823:LOC100155213
uniprot id: A0A4X1T964
uniprot id: F1S627
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC106504264
gene id: 9823:LOC106504264
uniprot id: A0A4X1SL23
uniprot id: A0A5G2QZW4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100157002
gene id: 9823:LOC100157002
uniprot id: A0A4X1SNR2
uniprot id: F1SB09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9823:NEK6
gene id: 9823:NEK6
uniprot id: A2BD05
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Phosphorylation at Ser-206 is required for its activation. Phosphorylated upon IR or UV-induced DNA damage. Phosphorylated by CHEK1 and CHEK2. Interaction with APBB1 down-regulates phosphorylation at Thr-210 (By similarity).
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
messages: Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-108.
messages: Cytoplasm
messages: Displays an autoinhibited conformation: Tyr-108 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9 (By similarity).
messages: Interacts with NEK9, predominantly in mitosis. Interacts with KIF11 (via C-terminus). Interacts with APBB1 (via WW domain). Interacts with ANKRA2, ATF4, ARHGAP33, CDC42, CIR1, PRAM1, PTN, PRDX3, PIN1, RAD26L, RBBP6, RPS7, RPS6KB1, STAT3 and TRIP4 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By similarity). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity).
messages: centrosome
messages: spindle pole

9823:TLR6
gene id: 9823:TLR6
uniprot id: Q59HI6
uniprot id: Q76L23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9823:TM4SF19
gene id: 9823:TM4SF19
uniprot id: A0A8D1H315
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9823:TNP2
gene id: 9823:TNP2
uniprot id: A0A4X1VNK8
uniprot id: I3LNZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Nucleus
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.

9823:PFDN1
gene id: 9823:PFDN1
uniprot id: A0A287BED1
uniprot id: A0A4X1SDR8
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9823:HAO2
gene id: 9823:HAO2
uniprot id: A0A287BQZ1
uniprot id: A0A4X1SSX5
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9823:GRN
gene id: 9823:GRN
uniprot id: Q1EG87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

9823:IGFBP4
gene id: 9823:IGFBP4
uniprot id: P24854
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Secreted

9823:TAS2R9
gene id: 9823:TAS2R9
uniprot id: A0A8D0UG09
uniprot id: F1SQ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9823:NSMCE4A
gene id: 9823:NSMCE4A
uniprot id: A0A480KRR1
uniprot id: A0A8D2CDD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

9823:NIF3L1
gene id: 9823:NIF3L1
uniprot id: A0A287ASH3
uniprot id: A0A287B238
uniprot id: A0A4X1V7Q5
uniprot id: A0A4X1VDM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9823:ARL4D
gene id: 9823:ARL4D
uniprot id: A0A4X1TTS5
uniprot id: F1S1H1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9823:CORO1C
gene id: 9823:CORO1C
uniprot id: A0A4X1SR04
uniprot id: F1RGA9
names: Similarity
messages: Belongs to the WD repeat coronin family.

9823:ATP6V1E2
gene id: 9823:ATP6V1E2
uniprot id: A0A8D0U5A2
uniprot id: F1S5M0
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9823:ANGPT2
gene id: 9823:ANGPT2
uniprot id: Q9BDY7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.
messages: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. Interacts with ITGA5.
messages: Secreted
messages: The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.

9823:LCAT
gene id: 9823:LCAT
uniprot id: C7S7Z9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9823:UBE2D3
gene id: 9823:UBE2D3
uniprot id: Q06AA9
names: Function
names: Similarity
names: Subunit
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3. Interacts with PPP1R11.

9823:IRF3
gene id: 9823:IRF3
uniprot id: Q764M6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with African swine fever virus (ASFV) E301R; this interaction inhibits nuclear translocation of IRF3 to the nucleus.
messages: (Microbial infection) Interacts with African swine fever virus (ASFV) MGF360-14L; this interaction mediates degradation of IRF3 through TRIM21 and ubiquitin-meditated proteolysis.
messages: (Microbial infection) Interacts with African swine fever virus (ASFV) P14.5/E120R; this interaction interfers with the recruitment of IRF3 to TBK1, which in turn suppresses IRF3 phosphorylation, decreasing interferon production via the cGAS/STING pathway.
messages: (Microbial infection) Interacts with African swine fever virus (ASFV) minor capsid protein M1249L; this interaction mediates IRF3 degradation.
messages: (Microbial infection) Interacts with Porcine epidemic diarrhea virus E protein; this interaction prevents IRF3 translocation to the nucleus and thereby prevents type I interferon production.
messages: Belongs to the IRF family.
messages: Constitutively phosphorylated on many Ser/Thr residues. Activated following phosphorylation by TBK1 and IKBKE. Innate adapter protein MAVS, STING1 or TICAM1 are first activated by viral RNA, cytosolic DNA, and bacterial lipopolysaccharide (LPS), respectively, leading to activation of the kinases TBK1 and IKBKE. These kinases then phosphorylate the adapter proteins on the pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1. Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs.
messages: Cytoplasm
messages: ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation.
messages: In the absence of viral infection, maintained as a monomer in an autoinhibited state. Phosphorylation by TBK1 and IKBKE disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes. Phosphorylation and activation follow the following steps: innate adapter protein MAVS, STING1 or TICAM1 are first activated by viral RNA, cytosolic DNA and bacterial lipopolysaccharide (LPS), respectively, leading to activation of the kinases TBK1 and IKBKE. These kinases then phosphorylate the adapter proteins on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1. Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs.
messages: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
messages: Mitochondrion
messages: Monomer. Homodimer; phosphorylation-induced. Interacts (when phosphorylated) with CREBBP. Interacts with MAVS (via phosphorylated pLxIS motif). Interacts with TICAM1 (via phosphorylated pLxIS motif). Interacts with STING1 (via phosphorylated pLxIS motif). Interacts with IKBKE and TBK1. Interacts with TICAM2. Interacts with RBCK1. Interacts with HERC5. Interacts with DDX3X; the interaction allows the phosphorylation and activation of IRF3 by IKBKE. Interacts with TRIM21 and ULK1, in the presence of TRIM21; this interaction leads to IRF3 degradation by autophagy. Interacts with RIOK3; RIOK3 probably mediates the interaction of TBK1 with IRF3. Interacts with ILRUN; the interaction inhibits IRF3 binding to its DNA consensus sequence. Interacts with LYAR; this interaction impairs IRF3 DNA-binding activity. Interacts with TRAF3. Interacts with ZDHHC11; ZDHHC11 recruits IRF3 to STING1 upon DNA virus infection and thereby promotes IRF3 activation (By similarity). Interacts with HSP90AA1; the interaction mediates IRF3 association with TOMM70. Interacts with BCL2; the interaction decreases upon Sendai virus infection. Interacts with BAX; the interaction is direct, increases upon virus infection and mediates the formation of the apoptosis complex TOMM70:HSP90AA1:IRF3:BAX (By similarity). Interacts with DDX56 (By similarity). Interacts with NBR1 (By similarity).
messages: Nucleus
messages: Proteolytically cleaved by apoptotic caspases during apoptosis, leading to its inactivation. Cleavage by CASP3 during virus-induced apoptosis inactivates it, preventing cytokine overproduction.
messages: Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination involves TRIM21 leading to proteasomal degradation. Ubiquitinated by UBE3C, leading to its degradation.

9823:IL5
gene id: 9823:IL5
uniprot id: Q9MYM5
uniprot id: R9UCF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9823:FGFR1OP
gene id: 9823:FGFR1OP
uniprot id: A0A480K4F7
uniprot id: A0A8D0NMT2
uniprot id: F1SBY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9823:ABCD1
gene id: 9823:ABCD1
uniprot id: A0A8D0TH65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9823:TSPAN9
gene id: 9823:TSPAN9
uniprot id: Q06AA5
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Found in a complex with GP6.
messages: Glycosylated.
messages: Membrane

9823:ATG5
gene id: 9823:ATG5
uniprot id: Q3MQ04
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300.
messages: Belongs to the ATG5 family.
messages: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
messages: Cytoplasm
messages: Forms a conjugate with ATG12. The ATG5-ATG12 conjugate forms a complex with several units of ATG16L1. Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (By similarity). Interacts with TECPR1; the interaction is direct and does not take place when ATG16L1 is associated with the ATG5-ATG12 conjugate. Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate form. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection. Interacts with ATG3 (By similarity). Interacts with ATG7 and ATG10 (By similarity). Interacts with FADD (By similarity). Interacts with ATG16L2 (By similarity).
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9823:MRPL17
gene id: 9823:MRPL17
uniprot id: A0A8D1NJE7
uniprot id: F1RMQ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9823:RGS14
gene id: 9823:RGS14
uniprot id: A0A4X1SFA4
uniprot id: F1S3D6
names: Subcellular Location Annotation
messages: dendrite

9823:NR6A1
gene id: 9823:NR6A1
uniprot id: A0A4X1UHH0
uniprot id: A0P8Z4
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR6 subfamily.
messages: Homodimer. Interacts with UIMC1 (By similarity).
messages: Nucleus
messages: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).
messages: The polymorphism in position 192 seems to be responsible for the increase in number of vertebrae in domestic pigs. Wild boars uniformly have 19 vertebrae, while European commercial breeds have 21 to 23 vertebrae The ancestral form with Leu-192 has a 3 times lower binding activity to UIMC1 than Pro-192. The binding to NCOR1 is twice lower with Leu-192 than with Pro-192.

9823:F3
gene id: 9823:F3
uniprot id: Q6RCS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9823:ADRB1
gene id: 9823:ADRB1
uniprot id: Q28998
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).
messages: Cell membrane
messages: Early endosome
messages: Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
messages: Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4 (By similarity).
messages: The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.

9823:APPL2
gene id: 9823:APPL2
uniprot id: A0A4X1TB82
uniprot id: B6DZ39
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9823:CEPT1
gene id: 9823:CEPT1
uniprot id: A0A4X1TAC1
uniprot id: A0A8D1QJK1
uniprot id: I3LAL7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9823:NKX2-2
gene id: 9823:NKX2-2
uniprot id: A0A287BDA9
uniprot id: A0A4X1V3H7
names: Subcellular Location Annotation
messages: Nucleus

9823:TMPRSS4
gene id: 9823:TMPRSS4
uniprot id: A0A287BAL3
uniprot id: A0A4X1STB8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CLIC5
gene id: 9823:CLIC5
uniprot id: A0A5G2QKB6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9823:TTL
gene id: 9823:TTL
uniprot id: P38160
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
messages: Monomer.

9823:BRCA1
gene id: 9823:BRCA1
uniprot id: A0A286ZS33
uniprot id: A0A4X1TRD4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.
messages: Nucleus

9823:MED31
gene id: 9823:MED31
uniprot id: A0A4X1UL35
uniprot id: I3LLR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9823:SLC30A4
gene id: 9823:SLC30A4
uniprot id: A0A4X1SDW2
uniprot id: B5ACE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9823:UBN1
gene id: 9823:UBN1
uniprot id: A0A4X1VLG2
uniprot id: A0A4X1VQM9
uniprot id: F1RK94
names: Similarity
messages: Belongs to the ubinuclein family.

9823:PMPCB
gene id: 9823:PMPCB
uniprot id: A0A480T8S4
uniprot id: A0A8D2A151
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Mitochondrion matrix

9823:PNOC
gene id: 9823:PNOC
uniprot id: A0A287BEQ0
uniprot id: A0A4X1VC70
uniprot id: F1RJR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9823:E2F4
gene id: 9823:E2F4
uniprot id: A0A8D1T6B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9823:LOC100520039
gene id: 9823:LOC100520039
uniprot id: A0A8D1XET8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NOTO
gene id: 9823:NOTO
uniprot id: A0A4X1W250
uniprot id: F1SLF3
names: Subcellular Location Annotation
messages: Nucleus

9823:SLC39A7
gene id: 9823:SLC39A7
uniprot id: A0A8D0UY20
uniprot id: A5D9P2
uniprot id: M9MMN1
names: Subcellular Location Annotation
messages: Membrane

9823:BRS3
gene id: 9823:BRS3
uniprot id: A0A287B8U3
uniprot id: A0A4X1SFP0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9823:PRKAG3
gene id: 9823:PRKAG3
uniprot id: Q9MYP4
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity).
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.
messages: Defects in PRKAG3 are the cause of the RN- phenotype which is associated with excess glycogen content (about 70%) in skeletal muscle. This mutation originated in the hampshire breed pigs and has beneficial effects on meat content but detrimental effects on processing yield.
messages: Muscle.
messages: Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
messages: The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high-affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP.
messages: The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1 (By similarity).

9823:ATP5J2
gene id: 9823:ATP5J2
uniprot id: Q95339
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase F chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9823:RPL10A
gene id: 9823:RPL10A
uniprot id: A0A4X1T0H0
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9823:LOC100514797
gene id: 9823:LOC100514797
uniprot id: A0A5G2R066
uniprot id: A0A8D1TQZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100524576
gene id: 9823:LOC100524576
uniprot id: A0A4X1VDL9
uniprot id: A0A5G2QW67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ITGAL
gene id: 9823:ITGAL
uniprot id: A0A8D1B4R6
uniprot id: Q30KI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9823:SRSF4
gene id: 9823:SRSF4
uniprot id: A0A8D0T353
uniprot id: Q06A99
names: Similarity
messages: Belongs to the splicing factor SR family.

9823:IL17RB
gene id: 9823:IL17RB
uniprot id: A0A287ACJ1
uniprot id: A0A4X1VKS3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:ACO1
gene id: 9823:ACO1
uniprot id: A0A287BQT2
uniprot id: A0A4X1UMC0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

9823:SV2B
gene id: 9823:SV2B
uniprot id: A0A4X1UER6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9823:ACTL7B
gene id: 9823:ACTL7B
uniprot id: A0A8D1MNQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9823:MC2R
gene id: 9823:MC2R
uniprot id: Q8HYN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in skin and adrenal gland tissues.
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH) (By similarity).
messages: Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP).

9823:TTC4
gene id: 9823:TTC4
uniprot id: A0A8D1RVU2
names: Similarity
messages: Belongs to the TTC4 family.

9823:ADAM30
gene id: 9823:ADAM30
uniprot id: A0A4X1TA74
uniprot id: F1SB05
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100156374
gene id: 9823:LOC100156374
uniprot id: A0A8D0IW22
uniprot id: F1SNC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MME
gene id: 9823:MME
uniprot id: A0A287BPD6
uniprot id: A0A4X1SQE6
names: Cofactor
messages: Binds 1 zinc ion per subunit.

9823:PABPN1
gene id: 9823:PABPN1
uniprot id: A0A287ASR3
uniprot id: A0A8D1CWI4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:HOXA6
gene id: 9823:HOXA6
uniprot id: A0A4X1TPF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:OSTF1
gene id: 9823:OSTF1
uniprot id: Q8MJ49
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
messages: Interacts with SRC and SMN1. Interacts with FASLG (By similarity).
messages: The SH3 domain mediates interaction with SMN1.

9823:LOC100622127
gene id: 9823:LOC100622127
uniprot id: A0A5G2QHE1
uniprot id: A0A8D0ZJM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:KMO
gene id: 9823:KMO
uniprot id: A0A8D1IRP1
uniprot id: I3LAL5
uniprot id: Q9MZS9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane
messages: Transmembrane domains are required for enzymatic activity.

9823:TRNAU1AP
gene id: 9823:TRNAU1AP
uniprot id: A0A287AQ52
uniprot id: A0A4X1TH90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9823:DMBT1
gene id: 9823:DMBT1
uniprot id: Q4A3R3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DMBT1 family.
messages: Highly N- and O-glycosylated. The O-glycans are heavily sulfated (By similarity).
messages: Interacts with LGALS3. Binds SFTPD and SPAR in a calcium-dependent manner (By similarity).
messages: May play roles in mucosal defense system and cellular immune defense. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell (By similarity).
messages: Secreted
messages: The SRCR domains mediate binding to bacteria.
messages: secretory vesicle membrane

9823:S100Z
gene id: 9823:S100Z
uniprot id: A0A8D1PP46
names: Similarity
messages: Belongs to the S-100 family.

9823:PROKR2
gene id: 9823:PROKR2
uniprot id: A0A286ZK57
uniprot id: A0A8D1B666
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9823:CRYBB3
gene id: 9823:CRYBB3
uniprot id: A0A4X1SM32
uniprot id: F2Z4Y7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9823:GNB3
gene id: 9823:GNB3
uniprot id: A0A4X1UYE5
uniprot id: F1SLU8
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9823:DMD
gene id: 9823:DMD
uniprot id: Q5GN48
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
messages: In the retina, expressed in the outer plexiform layer (OPL) and around the blood vessels. Also observed at the vitreal border of the retina corresponding to the inner limiting membrane (ILM). Presynaptically localized in cone pedicles and postsynaptically in bipolar cells (at protein level).
messages: Interacts with SYNM (By similarity). Interacts with the syntrophins SNTG1 and SNTG2. Interacts with KRT19. Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1 (By similarity). Interacts with SYNM; SNTA1 and SNTB1. Interacts with CMYA5. Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells. Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity). Interacts with DTNB (By similarity). Interacts with PGM5; the interaction is direct (By similarity).
messages: Postsynaptic cell membrane
messages: cytoskeleton
messages: sarcolemma

9823:SPR
gene id: 9823:SPR
uniprot id: A0A480ZCU6
uniprot id: A0A4X1W9A7
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9823:LOC100521680
gene id: 9823:LOC100521680
uniprot id: K9IWF3
uniprot id: Q71LE2
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed throughout the cell cycle independently of DNA synthesis.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity). Interacts with ASF1A, MCM2, NASP and SPT2 (By similarity).
messages: Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

9823:ACSM3
gene id: 9823:ACSM3
uniprot id: A0A8D0Z227
uniprot id: A0A8D1M2T8
uniprot id: F1RPB1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:VLDLR
gene id: 9823:VLDLR
uniprot id: A0A481B6P9
uniprot id: A0A4X1W8P4
uniprot id: A0A8D1YMR3
uniprot id: E7CXS1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: clathrin-coated pit

9823:LEFTY2
gene id: 9823:LEFTY2
uniprot id: A0A8D1ERX8
uniprot id: D3K5M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9823:PDE6C
gene id: 9823:PDE6C
uniprot id: A0A4X1UQX4
uniprot id: F1SC79
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9823:GABRR1
gene id: 9823:GABRR1
uniprot id: A0A4X1VEA9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:CLCN6
gene id: 9823:CLCN6
uniprot id: A0A481AIE6
uniprot id: A0A4X1W2C6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:SEMA3G
gene id: 9823:SEMA3G
uniprot id: F1SIW2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:BPI
gene id: 9823:BPI
uniprot id: A0A480QIP2
uniprot id: C1KBY9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Cytoplasmic granule membrane
messages: Membrane
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9823:SOAT1
gene id: 9823:SOAT1
uniprot id: A0A8D0XBF5
uniprot id: I3L5S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:EXO5
gene id: 9823:EXO5
uniprot id: A0A4X1VIA1
uniprot id: F1SCQ8
names: Similarity
messages: Belongs to the EXO5 family.

9823:MPPED2
gene id: 9823:MPPED2
uniprot id: A0A4X1SVY5
uniprot id: F1SGP0
names: Similarity
messages: Belongs to the UPF0046 family.

9823:FARSA
gene id: 9823:FARSA
uniprot id: A0A4X1TE37
uniprot id: F1SD97
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

9823:DIS3L2
gene id: 9823:DIS3L2
uniprot id: D3K5M4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

9823:POP7
gene id: 9823:POP7
uniprot id: A0A4X1UCQ2
uniprot id: F1RMX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9823:CXCL8
gene id: 9823:CXCL8
uniprot id: P26894
uniprot id: Q68CM2
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alveolar macrophages.
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: By lipopolysaccharide (LPS).
messages: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
messages: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
messages: Homodimer.
messages: Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.
messages: Secreted

9823:GMPPB
gene id: 9823:GMPPB
uniprot id: A0A4X1SQL6
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9823:S100A4
gene id: 9823:S100A4
uniprot id: A0A8D0LL36
uniprot id: F1SFV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9823:POMC
gene id: 9823:POMC
uniprot id: P01192
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: ACTH and MSH are produced by the pituitary gland.
messages: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Endogenous orexigenic opiate.
messages: Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Secreted
messages: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
messages: Stimulates the adrenal glands to release cortisol.

9823:IGFBP5
gene id: 9823:IGFBP5
uniprot id: Q28985
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Secreted

9823:PHTF2
gene id: 9823:PHTF2
uniprot id: A0A4X1SEH5
uniprot id: A0A5G2QZY9
names: Subcellular Location Annotation
messages: Membrane

9823:DUT
gene id: 9823:DUT
uniprot id: A0A287AX05
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

9823:LOC100516001
gene id: 9823:LOC100516001
uniprot id: A0A4X1TYA9
uniprot id: F1RFM2
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9823:IFN-DELTA-2
gene id: 9823:IFN-DELTA-2
uniprot id: C8CKB2
uniprot id: Q29115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:DHX29
gene id: 9823:DHX29
uniprot id: A0A8D1NEY3
uniprot id: I3LQ47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

9823:AFM
gene id: 9823:AFM
uniprot id: A0A8D0KJS1
uniprot id: F1RUM1
names: Subcellular Location Annotation
messages: Secreted

9823:MRPL50
gene id: 9823:MRPL50
uniprot id: A0A8D1EHA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9823:PMM1
gene id: 9823:PMM1
uniprot id: A0A4X1VXB7
uniprot id: F1SRD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9823:TNFSF10
gene id: 9823:TNFSF10
uniprot id: A0A4X1V8G6
uniprot id: Q4VSR6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9823:ATG4B
gene id: 9823:ATG4B
uniprot id: A0A8D1AWD2
uniprot id: D7RA22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: autophagosome
messages: cytosol

9823:SEMA6A
gene id: 9823:SEMA6A
uniprot id: A0A287AN44
uniprot id: A0A287B6K3
uniprot id: A0A4X1U662
uniprot id: A0A4X1U8Q6
uniprot id: A0A8D0M9J4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100626407
gene id: 9823:LOC100626407
uniprot id: A0A480F155
names: Subcellular Location Annotation
messages: Membrane

9823:FGF5
gene id: 9823:FGF5
uniprot id: A0A287AAE4
uniprot id: A0A4X1T0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted

9823:SLC43A2
gene id: 9823:SLC43A2
uniprot id: A0A286ZW93
uniprot id: A0A480EJY2
uniprot id: A0A4X1U286
uniprot id: A0A4X1U7I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
messages: Membrane

9823:CCNA1
gene id: 9823:CCNA1
uniprot id: F1RSR0
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9823:PEX10
gene id: 9823:PEX10
uniprot id: A0A4X1W8U7
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9823:ITGB1
gene id: 9823:ITGB1
uniprot id: A0A4X1TP89
uniprot id: K7GNY7
uniprot id: Q9GLP0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Cell surface
messages: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, …
messages: Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner (By similarity). Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB, FLNC and RANBP9. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with MYO10. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with DAB2. Interacts with FGR and HCK. Isoform 2 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 2 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (By similarity). ITGA5:ITGB1 interacts with CCN3 (By similarity). ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (By similarity). ITGA5:ITGB1 interacts with FBN1 (By similarity). ITGA5:ITGB1 interacts with IL1B. Interacts with MDK. ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation. ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outg…
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: The cysteine residues are involved in intrachain disulfide bonds.
messages: Widely expressed.
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle
messages: ruffle membrane

9823:SLC7A3
gene id: 9823:SLC7A3
uniprot id: B3VN79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9823:TSPAN14
gene id: 9823:TSPAN14
uniprot id: A0A481B903
uniprot id: A0A4X1SH99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:IVD
gene id: 9823:IVD
uniprot id: D0G773
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9823:SLC12A9
gene id: 9823:SLC12A9
uniprot id: A0A8D1XL87
uniprot id: I3LUK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9823:FXYD5
gene id: 9823:FXYD5
uniprot id: A0A480K3L9
names: Similarity
messages: Belongs to the FXYD family.

9823:KCNJ5
gene id: 9823:KCNJ5
uniprot id: O02670
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: May associate with GIRK1 and GIRK2 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

9823:LOC100625049
gene id: 9823:LOC100625049
uniprot id: A0A481CVE5
uniprot id: A0A4X1T1T9
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9823:ARPC5
gene id: 9823:ARPC5
uniprot id: A0A4X1TX88
uniprot id: B5APV0
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9823:CNOT8
gene id: 9823:CNOT8
uniprot id: A0A4X1TTX9
uniprot id: F2Z590
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9823:IGFBP2
gene id: 9823:IGFBP2
uniprot id: E3W6T5
uniprot id: P24853
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May have both growth-inhibiting and growth-promoting effects, depending on tissue type; increases IGF-induced DNA synthesis in the uterine epithelium. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: O-glycosylated.
messages: Secreted
messages: The C-terminus is required for IGF-binding and growth inhibition.

9823:SLC16A9
gene id: 9823:SLC16A9
uniprot id: A0A287BA41
uniprot id: A0A4X1U1R0
uniprot id: A0A4X1U4F4
uniprot id: F1RG05
names: Subcellular Location Annotation
messages: Membrane

9823:RPS27
gene id: 9823:RPS27
uniprot id: A0A287BF06
uniprot id: A0A4X1W2B6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9823:CD200R1L
gene id: 9823:CD200R1L
uniprot id: A0A8D1FDD3
uniprot id: K7GLQ4
names: Similarity
messages: Belongs to the CD200R family.

9823:GPT2
gene id: 9823:GPT2
uniprot id: A0A287BGP0
uniprot id: A0A4X1TXF2
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9823:KRI1
gene id: 9823:KRI1
uniprot id: A0A8D1V6V7
uniprot id: F1S3M3
names: Similarity
messages: Belongs to the KRI1 family.

9823:FAM13C
gene id: 9823:FAM13C
uniprot id: A0A287A5L8
uniprot id: A0A4X1U4C4
uniprot id: A0A4X1U4T9
uniprot id: F1RG06
names: Similarity
messages: Belongs to the FAM13 family.

9823:SERPINC1
gene id: 9823:SERPINC1
uniprot id: A0A8D1FBQ8
uniprot id: Q19AZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9823:WDR91
gene id: 9823:WDR91
uniprot id: A0A480JW78
uniprot id: A0A4X1VS01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9823:RAB27A
gene id: 9823:RAB27A
uniprot id: A0A480LWT0
uniprot id: Q4LE85
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5. Interacts with RPH3A and RPH3A (By similarity). Binds MLPH and SYTL2. Interacts with UNC13D. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (By similarity). Interacts (GDP-bound form preferentially) with DENND10 (By similarity).
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Melanosome
messages: Membrane
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as DENND10.
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

9823:FGF19
gene id: 9823:FGF19
uniprot id: A0A287B3V5
uniprot id: A0A4X1SJA6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:LOC100156293
gene id: 9823:LOC100156293
uniprot id: A0A4X1W7C1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9823:TFB1M
gene id: 9823:TFB1M
uniprot id: B2MUB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9823:ARF6
gene id: 9823:ARF6
uniprot id: C4MQ03
uniprot id: Q007T5
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). Activated by ASAP3. Inactivated by ACAP1 and ACAP2 (By similarity). Activated by NGF via NTRK1 (By similarity).
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Early endosome membrane
messages: Endosome membrane
messages: GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity).
messages: GTP-bound form is myristoylated on Lys-3 by NMT1 and NMT2, allowing ARF6 to remain on membranes during the GTPase cycle, thereby promoting its activity. GDP-bound inactive form is demyristoylated on Lys-3 by SIRT2 at early endosomes or endocytic recycling compartment to allow its efficient activation by a guanine exchange factor (GEF) after GDP release.
messages: Interacts (when activated) with GGA1, GGA2 and GGA3; the interaction is required for proper subcellular location of GGA1, GGA2 and GGA3 (By similarity). Interacts with PIP5K1C. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with RAB11FIP3 and RAB11FIP4. Interacts with HERC1. Interacts with ARHGAP21. Interacts with ASAP3; the interaction is stabilized by calcium ions. Interacts with NCS1/FREQ at the plasma membrane. Interacts with TBC1D24. Interacts with ECPAS. Interacts with MICALL1. Interacts with SPAG9 homodimers, forming heterotetramers. Interacts with CYTH3 (By similarity). Interacts with ASAP2 (By similarity). Interacts with UACA (By similarity). Interacts with KIF23, forming heterodimers and heterotetramers (By similarity). Interacts with C9orf72 (By similarity). Interacts (GTP-bound form) with TJAP1/PILT (By similarity).
messages: Midbody ring
messages: Recycling endosome membrane
messages: cytosol
messages: filopodium membrane
messages: ruffle
messages: trans-Golgi network membrane

9823:ALDH2
gene id: 9823:ALDH2
uniprot id: Q2XQV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.

9823:TMEM186
gene id: 9823:TMEM186
uniprot id: A0A287AQT2
uniprot id: A0A8D0VIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9823:LTA4H
gene id: 9823:LTA4H
uniprot id: D0G776
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9823:PRKACA
gene id: 9823:PRKACA
uniprot id: A0A287ACC3
uniprot id: A0A4X1VAB5
uniprot id: A0A4X1VAC1
uniprot id: F1SD45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Nucleus

9823:DDB1
gene id: 9823:DDB1
uniprot id: A0A4X1VLC3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9823:LOC100151870
gene id: 9823:LOC100151870
uniprot id: A0A4X1SXI7
uniprot id: F1RRS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9823:GPR55
gene id: 9823:GPR55
uniprot id: A0A287A4Z4
uniprot id: A0A4X1TI50
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:LOC100154782
gene id: 9823:LOC100154782
uniprot id: A0A4X1SNR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:MX2
gene id: 9823:MX2
uniprot id: A0PJ12
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9823:RPL36AL
gene id: 9823:RPL36AL
uniprot id: P83884
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:CLK1
gene id: 9823:CLK1
uniprot id: A0A4X1VBB5
uniprot id: B1A9K1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:TNP1
gene id: 9823:TNP1
uniprot id: P17306
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear transition protein 1 family.
messages: Chromosome
messages: Nucleus
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: Testis.

9823:BHMT2
gene id: 9823:BHMT2
uniprot id: E7D6R3
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9823:PNLDC1
gene id: 9823:PNLDC1
uniprot id: A0A4X1VVB4
uniprot id: F1SB65
names: Similarity
messages: Belongs to the CAF1 family.

9823:FOXA3
gene id: 9823:FOXA3
uniprot id: A0A4X1W2C2
names: Subcellular Location Annotation
messages: Nucleus

9823:C2H5orf24
gene id: 9823:C2H5orf24
uniprot id: A0A480EPF8
uniprot id: A0A4X1V145
uniprot id: A0A4X1V155
uniprot id: A0A5G2Q9T2
names: Similarity
messages: Belongs to the UPF0461 family.

9823:MZT1
gene id: 9823:MZT1
uniprot id: A0A287AS02
uniprot id: A0A4X1VBW8
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9823:DPYSL5
gene id: 9823:DPYSL5
uniprot id: A0A4X1TP24
uniprot id: F1SDQ2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9823:FDX1
gene id: 9823:FDX1
uniprot id: P00258
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adrenodoxin/putidaredoxin family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons.
messages: Interacts with CYP11A1.
messages: Mitochondrion matrix

9823:LOC780435
gene id: 9823:LOC780435
uniprot id: Q000H9
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9823:KCNK4
gene id: 9823:KCNK4
uniprot id: A0A4X1VD02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:CAPN3
gene id: 9823:CAPN3
uniprot id: A0A287BSN0
uniprot id: A0A4X1V0D1
uniprot id: A0A4X1V1W9
uniprot id: A0A8D0RVE7
uniprot id: P43368
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by micromolar concentrations of calcium and inhibited by calpastatin.
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.
messages: Cytoplasm
messages: Homodimer.
messages: Homodimer; via EF-hand domain 4. Interacts with TTN/titin. Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis. Interacts with SIMC1. Interacts with UTP25; the interaction is required for CAPN3 translocation to the nucleolus.
messages: Skeletal muscle.
messages: nucleolus

9823:NSUN3
gene id: 9823:NSUN3
uniprot id: A0A8D1X534
uniprot id: I3LUW7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9823:NNAT
gene id: 9823:NNAT
uniprot id: Q0Q043
names: Function
names: Similarity
messages: Belongs to the neuronatin family.
messages: May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels (By similarity).

9823:LOC100520442
gene id: 9823:LOC100520442
uniprot id: A0A287ALI3
uniprot id: A0A4X1V971
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MRPS24
gene id: 9823:MRPS24
uniprot id: A0A4X1U9V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9823:LOC100155779
gene id: 9823:LOC100155779
uniprot id: A0A8D1D055
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ACBD5
gene id: 9823:ACBD5
uniprot id: A0A287BIS1
uniprot id: A0A8D1QX96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9823:LY75
gene id: 9823:LY75
uniprot id: D6MT50
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CLUAP1
gene id: 9823:CLUAP1
uniprot id: A0A480TL40
uniprot id: A0A4X1VT63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9823:DNAJC22
gene id: 9823:DNAJC22
uniprot id: F1SHB7
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9823:SGO2
gene id: 9823:SGO2
uniprot id: A0A4X1VCI2
uniprot id: F1SI67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9823:DDX52
gene id: 9823:DDX52
uniprot id: A0A4X1T487
uniprot id: I3LJA0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9823:FUT8
gene id: 9823:FUT8
uniprot id: A0A480QKH0
uniprot id: A0A4X1UCP2
uniprot id: P79282
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Highest expression in brain.
messages: Membrane
messages: Tyrosine phosphorylated by PKDCC/VLK.

9823:ETFB
gene id: 9823:ETFB
uniprot id: A0A480F228
uniprot id: Q6UAQ8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer composed of ETFA and ETFB (PubMed:6847633). Identified in a complex that contains ETFA, ETFB and ETFRF1. Interacts with ACADM (By similarity).
messages: Heterodimer of an alpha and a beta subunit.
messages: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.
messages: Methylated. Trimethylation at Lys-200 and Lys-203 may negatively regulate the activity in electron transfer from acyl-CoA dehydrogenases.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
messages: The recognition loop recognizes a hydrophobic patch at the surface of interacting dehydrogenases and acts as a static anchor at the interface.

9823:SLA-DRA
gene id: 9823:SLA-DRA
uniprot id: A0A8D1H5T7
uniprot id: Q31065
names: Similarity
messages: Belongs to the MHC class II family.

9823:CIAO1
gene id: 9823:CIAO1
uniprot id: A0A287AU46
uniprot id: A0A4X1VT24
uniprot id: A0A8D0XC22
uniprot id: F1SU35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9823:FFAR2-L
gene id: 9823:FFAR2-L
uniprot id: A0A4X1TJQ4
uniprot id: M9NLC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9823:ATP5F1
gene id: 9823:ATP5F1
uniprot id: A0A286ZYM6
uniprot id: A0A8D0MI69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9823:SELENOS
gene id: 9823:SELENOS
uniprot id: F1SR90
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with DERL1 and (via VIM motif) with VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP. Also interacts with DERL2, DERL3 and SELENOK. The SELENOK-SELENOS complex interacts with VCP (By similarity).
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity).
messages: Truncated SELENOS proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) and CRL2(KLHDC3) complexes, which recognizes the glycine (Gly) at the C-terminus of truncated SELENOS proteins. Truncated SELENOS proteins produced by failed UGA/Sec decoding are also ubiquitinated by the CRL5(KLHDC1) complex.
messages: Ubiquitously expressed. Highest expression in liver and lung, with lower levels detected in spleen, kidney, brain, lymph nodes, small intestine, stomach and heart. Very low expression detected in longissimus dorsi.

9823:TERF2
gene id: 9823:TERF2
uniprot id: A0A8D1CYM6
uniprot id: F1S2L2
names: Subcellular Location Annotation
messages: telomere

9823:SRP9
gene id: 9823:SRP9
uniprot id: A0A4X1T764
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9823:ACTR3
gene id: 9823:ACTR3
uniprot id: B5APU4
names: Similarity
messages: Belongs to the actin family. ARP3 subfamily.

9823:RARA
gene id: 9823:RARA
uniprot id: A0A287BAX0
uniprot id: A0A480PNE7
uniprot id: A0A4X1UBA7
uniprot id: A0A4X1UD10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:VAPB
gene id: 9823:VAPB
uniprot id: A5GFS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Homodimer, and heterodimer with VAPA. Interacts with RMDN3, VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27. Interacts with KIF5A in a ZFYVE27-dependent manner. Interacts with STARD3 (via FFAT motif) (By similarity). Interacts with STARD3NL (via FFAT motif) (By similarity). Interacts with CERT1 (By similarity). Interacts with PLEKHA3 and SACM1L to form a ternary complex (By similarity). Interacts with VPS13A (via FFAT motif) (By similarity).
messages: Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

9823:PRDX6
gene id: 9823:PRDX6
uniprot id: Q9TSX9
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration (By similarity). Interacts with APEX1. Interacts with STH. May interact with FAM168B (By similarity). May interact with HTR2A (By similarity).
messages: Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress.
messages: Lysosome
messages: Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme (By similarity). The phosphorylated form exhibits a greater lysophosphatidylcholine acyltransferase activity compared to the non-phosphorylated form (By similarity).
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) is reactivated by glutathionylation mediated by glutathione S-transferase Pi, followed by spontaneous reduction of the enzyme with glutathione.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity).

9823:SCNN1B
gene id: 9823:SCNN1B
uniprot id: A0A8D1J5I2
uniprot id: I3LGX7
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100626318
gene id: 9823:LOC100626318
uniprot id: A0A287A0V2
uniprot id: A0A4X1TWX6
names: Subcellular Location Annotation
messages: Membrane

9823:ADH4
gene id: 9823:ADH4
uniprot id: A0A0K1TQM8
uniprot id: A0A8D0PZV4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.

9823:REEP3
gene id: 9823:REEP3
uniprot id: A0A4X1TSY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9823:CD52
gene id: 9823:CD52
uniprot id: H8ZRT6
names: Function
names: Subcellular Location Annotation
messages: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
messages: Membrane

9823:ABCC3
gene id: 9823:ABCC3
uniprot id: A0A8D1AIG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9823:ASPHD1
gene id: 9823:ASPHD1
uniprot id: A0A4X1U2Y4
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9823:MRPL46
gene id: 9823:MRPL46
uniprot id: A0A4X1W787
uniprot id: F1SRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9823:SNAPIN
gene id: 9823:SNAPIN
uniprot id: A0A286ZUD5
uniprot id: A0A4X1VZY6
uniprot id: A0A8D0R6V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9823:FZD2
gene id: 9823:FZD2
uniprot id: D3K5N8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:RHCE
gene id: 9823:RHCE
uniprot id: A0A4X1VTK0
uniprot id: Q8SQH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9823:NMB
gene id: 9823:NMB
uniprot id: B0LUW4
uniprot id: P01297
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: During the sow estrus cycle, highest levels are found in the hypothalamus during proestrus, decrease during estrus and metestrus and increase again during diestrus. In the pituitary gland, levels decrease from proestrus to estrus, increase at metestrus and decrease again at diestrus. In the ovary, expression peaks at proestrus, decreases slightly at estrus, decreases significantly at metestrus and increases at diestrus. During boar postnatal development, expression peaks in the hypothalamus at day 60 and decreases thereafter. In the pituitary gland, expression peaks at day 30 and decreases thereafter. In the testis, expression peaks at day 3 with lowest levels at day 60 and expression then gradually increases from day 60 to day 120.
messages: Higher expression in the central nervous system (CNS) than in peripheral tissues. Highest levels are found in the olfactory bulb. Relatively high levels in the CNS (including the cerebral cortex, cerebellum, spinal cord, medulla oblongata, midbrain, hypothalamus, hippocampus, and hypophysis) and in peripheral tissues such as the pancreas, adrenal gland, testis, ovary and cecum. Moderate levels are found in the rectum, heart and pons with low expression levels detected in the bone marrow and duodenum. Other tissues show no or low levels of expression.
messages: Secreted
messages: Stimulates smooth muscle contraction (PubMed:6882442). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (PubMed:29632025). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (By similarity). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).
messages: neuron projection

9823:GSTA4
gene id: 9823:GSTA4
uniprot id: A0A4X1TD81
uniprot id: F1S7C8
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9823:PLA2G3
gene id: 9823:PLA2G3
uniprot id: A0A8D2C557
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9823:VASN
gene id: 9823:VASN
uniprot id: A0A4X1VSA9
uniprot id: I3LS87
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CHRNB3
gene id: 9823:CHRNB3
uniprot id: I3LLF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:ERF
gene id: 9823:ERF
uniprot id: A0A4X1SJQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:LOC100624389
gene id: 9823:LOC100624389
uniprot id: A0A8D1BQ86
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:ACOT6
gene id: 9823:ACOT6
uniprot id: A0A4X1TMR0
uniprot id: F1S3J0
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9823:C4BPA
gene id: 9823:C4BPA
uniprot id: A0A480QKV0
uniprot id: Q03472
names: Caution
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Forms high molecular weight disulfide-linked complexes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be a lipoprotein-borne regulator of either the coagulation or the complement cascades.
messages: Plasma. Found on very low-density lipoprotein (VLDL), on chylomicrons, and in the D > 1.21 g/ml fraction of pig plasma. Found in liver, spleen, lung, bone marrow and lymph node.
messages: Secreted
messages: Terminally differentiated macrophages.

9823:MRTO4
gene id: 9823:MRTO4
uniprot id: A0A480VYI2
uniprot id: A0A8D1HAQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9823:MBOAT4
gene id: 9823:MBOAT4
uniprot id: D7RJV9
names: Subcellular Location Annotation
messages: Membrane

9823:ARRDC4
gene id: 9823:ARRDC4
uniprot id: A0A4X1ULW1
uniprot id: F1SCJ8
names: Similarity
messages: Belongs to the arrestin family.

9823:GTPBP10
gene id: 9823:GTPBP10
uniprot id: A0A4X1UAB2
uniprot id: A0A8D0YEA9
uniprot id: A0A8D1AS56
uniprot id: F1S322
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9823:PHKA2
gene id: 9823:PHKA2
uniprot id: A0A286ZQP9
uniprot id: A0A480KNT6
uniprot id: A0A8D0PXM0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9823:LOC100522725
gene id: 9823:LOC100522725
uniprot id: A0A4X1VCV6
uniprot id: F1RPZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9823:LCTL
gene id: 9823:LCTL
uniprot id: A0A4X1T8X2
uniprot id: F1SJJ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9823:FAM45A
gene id: 9823:FAM45A
uniprot id: A0A4X1SX83
uniprot id: A0A4X1SXC8
uniprot id: F1S4P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

9823:RB1
gene id: 9823:RB1
uniprot id: J7FNA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9823:LOC100515044
gene id: 9823:LOC100515044
uniprot id: A0A287B264
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TYRP1
gene id: 9823:TYRP1
uniprot id: A0A4X1WAF7
uniprot id: F6Q7U8
uniprot id: Q4R1H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9823:LOC100156375
gene id: 9823:LOC100156375
uniprot id: A0A4X1U687
uniprot id: F1S8W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9823:USP37
gene id: 9823:USP37
uniprot id: A0A480TJS3
uniprot id: A0A8D0JIU5
uniprot id: A0A8D0JRC0
uniprot id: A0A8D0WHR0
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:LOC100626456
gene id: 9823:LOC100626456
uniprot id: A0A4X1TYH5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SDC1
gene id: 9823:SDC1
uniprot id: A0A4X1U4Q2
uniprot id: K7GNF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane
messages: extracellular exosome

9823:TCTN2
gene id: 9823:TCTN2
uniprot id: A0A480JYQ3
uniprot id: A0A4X1ULL0
uniprot id: A0A4X1UMW8
uniprot id: F1RFL8
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9823:SCGN
gene id: 9823:SCGN
uniprot id: Q06A97
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Secreted
messages: secretory vesicle membrane

9823:IP6K2
gene id: 9823:IP6K2
uniprot id: A0A287BS04
uniprot id: A0A4X1T105
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9823:CD3E
gene id: 9823:CD3E
uniprot id: Q7YRN2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6. Interacts with NCK1. Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation.

9823:SLC13A4
gene id: 9823:SLC13A4
uniprot id: A0A8D0YMJ0
uniprot id: F1SNI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9823:RDH14
gene id: 9823:RDH14
uniprot id: A0A4X1U5S6
uniprot id: F1SCT9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:PTPN11
gene id: 9823:PTPN11
uniprot id: A0A480ERB4
uniprot id: A0A480LMF4
uniprot id: A0A4X1TG72
uniprot id: A0A8D1HDC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9823:RAB3D
gene id: 9823:RAB3D
uniprot id: A0A4X1VJJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9823:UTS2B
gene id: 9823:UTS2B
uniprot id: A0A287BDR3
uniprot id: A0A4X1UC97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9823:TXNRD1
gene id: 9823:TXNRD1
uniprot id: Q8HZQ4
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

9823:BLOC1S5
gene id: 9823:BLOC1S5
uniprot id: A5A777
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity).
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Interacts with BLOC1S4, BLOC1S6, DTNBP1/BLOC1S7 and PI4K2A (By similarity).

9823:MTERF1
gene id: 9823:MTERF1
uniprot id: A0A286ZTW7
uniprot id: A0A287A9T5
uniprot id: A0A287AN15
uniprot id: A0A4X1U992
uniprot id: A0A8D1HV14
names: Similarity
messages: Belongs to the mTERF family.

9823:DEFB110
gene id: 9823:DEFB110
uniprot id: A0A8D0MKY5
uniprot id: Q6SC67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:PTGDR2
gene id: 9823:PTGDR2
uniprot id: A0A4X1VND5
uniprot id: K7GSF2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:LOC100621121
gene id: 9823:LOC100621121
uniprot id: A0A4X1VS04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:AATF
gene id: 9823:AATF
uniprot id: A0A4X1SYZ2
uniprot id: A0A5G2QIB9
names: Similarity
messages: Belongs to the AATF family.

9823:SPOUT1
gene id: 9823:SPOUT1
uniprot id: A0A480UFD7
uniprot id: A0A4X1TM33
uniprot id: A0A4X1TPQ1
uniprot id: F1RR63
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

9823:CD5L
gene id: 9823:CD5L
uniprot id: A0A8D0SYT8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CYR61
gene id: 9823:CYR61
uniprot id: A0A4X1UFQ6
uniprot id: A0A5G2QS80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:FSHB
gene id: 9823:FSHB
uniprot id: P01228
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.
messages: Secreted
messages: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.

9823:PRELID3B
gene id: 9823:PRELID3B
uniprot id: A5GFX0
names: Similarity
messages: Belongs to the slowmo family.

9823:SLC15A2
gene id: 9823:SLC15A2
uniprot id: A5A4L7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9823:OAZ3
gene id: 9823:OAZ3
uniprot id: A0A287B0J7
uniprot id: A0A8D1G8Z2
names: Similarity
messages: Belongs to the ODC antizyme family.

9823:UNC45A
gene id: 9823:UNC45A
uniprot id: A0A480X1W1
uniprot id: A0A8D0I6T6
names: Subcellular Location Annotation
messages: perinuclear region

9823:AHCY
gene id: 9823:AHCY
uniprot id: Q710C4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (By similarity). Binds copper ions (By similarity).
messages: Cytoplasm
messages: Homotetramer.
messages: Melanosome

9823:SOX10
gene id: 9823:SOX10
uniprot id: A5A763
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Mitochondrion outer membrane
messages: Monomer. Interacts with ARMCX3 at the mitochondrial outer membrane surface. Interacts with PAX3 (By similarity).
messages: Nucleus
messages: The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.
messages: Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (By similarity).

9823:LPIN1
gene id: 9823:LPIN1
uniprot id: B3VN77
names: Similarity
messages: Belongs to the lipin family.

9823:FAM210B
gene id: 9823:FAM210B
uniprot id: A0A8D1TZ85
uniprot id: A5GFW0
names: Similarity
messages: Belongs to the FAM210 family.

9823:EMC3
gene id: 9823:EMC3
uniprot id: A0A4X1UUJ9
uniprot id: F1SQC6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9823:SPAI-2
gene id: 9823:SPAI-2
uniprot id: P16225
names: Domain
names: Function
names: PTM
names: Tissue Specificity
messages: Inhibits Na(+),K(+) ATPase by the competitive mode against Na(+).
messages: Small intestine > large intestine. The plasma contains the pro-SPAI form circulating.
messages: The repetitive domain of pro-SPAI serves as a substrate for transglutaminase.
messages: The short form (AA 127-187) may be an artifact due to the strongly acidic conditions of the duodenum. The pro-SPAI form may be the native form.

9823:DYNC1LI2
gene id: 9823:DYNC1LI2
uniprot id: A0A287BSZ9
uniprot id: A0A8D0X6Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9823:RETN
gene id: 9823:RETN
uniprot id: A0A4X1VP29
uniprot id: Q6QR67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9823:ZFX
gene id: 9823:ZFX
uniprot id: A0A4X1VDH2
uniprot id: I3LL30
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100524972
gene id: 9823:LOC100524972
uniprot id: A0A8D2C485
names: Function
names: Similarity
messages: Belongs to the MS4A family.
messages: May be involved in signal transduction as a component of a multimeric receptor complex.

9823:RNASE10
gene id: 9823:RNASE10
uniprot id: Q8SPJ0
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pancreatic ribonuclease family.
messages: Male-specific expression in proximal caput of the epididymis.
messages: Represents 34% of the proteins secreted by the epididymis and 89% of the proteins secreted by the proximal caput.
messages: Secreted
messages: Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida (By similarity). Does not have ribonuclease activity.
messages: The N-terminus is blocked. Glycosylated.

9823:RUNX1
gene id: 9823:RUNX1
uniprot id: A0A4X1TP86
uniprot id: F8SIP5
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9823:PTPA
gene id: 9823:PTPA
uniprot id: A0A4X1TIP6
uniprot id: A0A4X1TLC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9823:AQP9
gene id: 9823:AQP9
uniprot id: A0A8D0K043
uniprot id: A8WCF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:AKAP4
gene id: 9823:AKAP4
uniprot id: A0A4X1SKT8
names: Similarity
messages: Belongs to the AKAP110 family.

9823:LOC100152566
gene id: 9823:LOC100152566
uniprot id: A0A287A5Z0
uniprot id: A0A4X1SGD7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9823:MKS1
gene id: 9823:MKS1
uniprot id: A0A4X1SK90
names: Subcellular Location Annotation
messages: cilium basal body

9823:FABP3
gene id: 9823:FABP3
uniprot id: E0AD19
uniprot id: O02772
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
messages: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

9823:PIK3C3
gene id: 9823:PIK3C3
uniprot id: Q5D891
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family.
messages: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
messages: Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are: the PI3K complex I (PI3KC3-C1) containing ATG14, and the PI3K complex II (PI3KC3-C2) containing UVRAG. PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex. Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits such as RUBCN, SH3GLB1/Bif-1 and AMBRA1. PI3KC3-C1 probably associates with PIK3CB. Interacts with RAB7A in the presence of PIK3R4. Interacts with AMBRA1. Interacts with BECN1P1/BECN2. Interacts with SLAMF1. May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (By similarity). Interacts with NCKAP1L (By similarity). Interacts with ATG14; this interaction is increased in the absence of TMEM39A (By similarity). Interacts with STEEP1; the interaction is STING1-dependent and required for trafficking of STING1 from the endoplasmic reticulum (By similarity). Interacts with YWHAG (By similarity).
messages: Late endosome
messages: Midbody
messages: Ubiquitinated via 'Lys-29'- and 'Lys-48'-linked ubiquitination by UBE3C, promoting its degradation. Deubiquitination by ZRANB1/TRABID promotes its stabilization, leading to autophagosome maturation.
messages: autophagosome

9823:SLC17A6
gene id: 9823:SLC17A6
uniprot id: A0A4X1T1J7
uniprot id: F1SFZ2
names: Subcellular Location Annotation
messages: Membrane

9823:RBM15B
gene id: 9823:RBM15B
uniprot id: A0A8D1JXD5
uniprot id: F1SIZ8
names: Similarity
messages: Belongs to the RRM Spen family.

9823:IGF1
gene id: 9823:IGF1
uniprot id: A0A288CFX8
uniprot id: A0A4X1T3B8
uniprot id: A0A4X1T4H1
uniprot id: A0A8D0UYR0
uniprot id: G9BFS5
uniprot id: G9BFS9
uniprot id: I3LBI3
uniprot id: P16545
uniprot id: Q45QB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).

9823:GSK3A
gene id: 9823:GSK3A
uniprot id: I6LNT8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9823:KRT82
gene id: 9823:KRT82
uniprot id: A0A4X1WC00
names: Similarity
messages: Belongs to the intermediate filament family.

9823:STAT2
gene id: 9823:STAT2
uniprot id: E7CR00
uniprot id: O02799
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with African swine fever virus (ASFV) MGF360-9L; this interaction mediates degradation of STAT1 through apoptosis.
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm. Interacts with CRSP2 and CRSP6. Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-467'. Interacts with IFNAR2. Interacts with ARL2BP (By similarity).
messages: Nucleus
messages: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.
messages: Tyrosine phosphorylated in response to IFN-alpha.

9823:SLC30A10
gene id: 9823:SLC30A10
uniprot id: A0A4X1TSD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9823:ADGRL2
gene id: 9823:ADGRL2
uniprot id: A0A480NR73
uniprot id: A0A4X1UWF3
uniprot id: A0A4X1UWJ5
uniprot id: A0A8D1NTY0
uniprot id: A0A8D1NTZ0
uniprot id: A0A8D1TPD5
uniprot id: A0A8D2BZL0
names: Subcellular Location Annotation
messages: Membrane

9823:CCL8
gene id: 9823:CCL8
uniprot id: A0A4X1T9X8
uniprot id: C7F842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:CCR9
gene id: 9823:CCR9
uniprot id: A0A4X1T8C4
uniprot id: Q6YT47
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:PRKAG1
gene id: 9823:PRKAG1
uniprot id: A0A4X1WCX5
uniprot id: A0A5S8K7Q3
uniprot id: D0G7E2
uniprot id: Q09138
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity).
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity).
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.
messages: Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.
messages: The 4 CBS domains mediate binding to nucleotides. Of the 4 potential nucleotide-binding sites, 3 are occupied, designated as sites 1, 3, and 4 based on the CBS modules that provide the acidic residue for coordination with the 2'- and 3'-hydroxyl groups of the ribose of AMP. Of these, site 4 appears to be a structural site that retains a tightly held AMP molecule (AMP 3). The 2 remaining sites, 1 and 3, can bind either AMP, ADP or ATP. Site 1 (AMP, ADP or ATP 1) is the high-affinity binding site and likely accommodates AMP or ADP. Site 3 (AMP, ADP or ATP 2) is the weakest nucleotide-binding site on the gamma subunit, yet it is exquisitely sensitive to changes in nucleotide levels and this allows AMPK to respond rapidly to changes in cellular energy status. Site 3 is likely to be responsible for protection of a conserved threonine in the activation loop of the alpha catalytic subunit through conformational changes induced by binding of AMP or ADP.
messages: The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1 (By similarity).

9823:YARS
gene id: 9823:YARS
uniprot id: A0A4X1VTE1
uniprot id: I3L804
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

9823:RHBDD3
gene id: 9823:RHBDD3
uniprot id: A0A287AKM9
uniprot id: A0A4X1VF40
uniprot id: A0A8D1X0X0
uniprot id: F1RFI9
names: Subcellular Location Annotation
messages: Membrane

9823:EOGT
gene id: 9823:EOGT
uniprot id: K9MA89
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9823:IDE
gene id: 9823:IDE
uniprot id: A0A287BBS8
uniprot id: A0A4X1UV52
uniprot id: A0A4X1UYL0
uniprot id: F1SC98
names: Similarity
messages: Belongs to the peptidase M16 family.

9823:DNPH1
gene id: 9823:DNPH1
uniprot id: A0A4X1V874
uniprot id: F1RRM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

9823:CCDC25
gene id: 9823:CCDC25
uniprot id: A0A286ZY28
uniprot id: A0A4X1V735
uniprot id: A0A4X1VBD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9823:VAT1
gene id: 9823:VAT1
uniprot id: A0A8D0YLH0
uniprot id: I3L9V2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9823:LOC100512461
gene id: 9823:LOC100512461
uniprot id: A0A287B4U3
uniprot id: A0A4X1SSF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PLIN3
gene id: 9823:PLIN3
uniprot id: Q5BLZ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the perilipin family.
messages: Cytoplasm
messages: Endosome membrane
messages: Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain).
messages: Lipid droplet
messages: Phosphorylation at Tyr-256 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis.
messages: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.

9823:NAP1L4
gene id: 9823:NAP1L4
uniprot id: I6NCL0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9823:TMEM176B
gene id: 9823:TMEM176B
uniprot id: A0A5G2R8T2
uniprot id: A0A8D1U6J8
uniprot id: F1SSL0
names: Similarity
messages: Belongs to the TMEM176 family.

9823:UBE2B
gene id: 9823:UBE2B
uniprot id: A0A4X1UY26
uniprot id: H8Y100
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:TNFSF8
gene id: 9823:TNFSF8
uniprot id: A0A4X1V0N6
uniprot id: Q4QTJ9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:CDSN
gene id: 9823:CDSN
uniprot id: A0A287AKM8
uniprot id: A0A8D0ZEE8
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9823:FGF6
gene id: 9823:FGF6
uniprot id: A0A287AFX3
uniprot id: A0A4X1UR46
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:PIGP
gene id: 9823:PIGP
uniprot id: A0A287B1D6
uniprot id: A0A4X1TPU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

9823:USP30
gene id: 9823:USP30
uniprot id: A0A4X1STA2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:PPP2R2A
gene id: 9823:PPP2R2A
uniprot id: A0A287BPB7
uniprot id: A0A4X1VCH2
uniprot id: A0A4X1VD60
uniprot id: A0A8D0UYW4
uniprot id: F2Z509
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9823:GLYATL2
gene id: 9823:GLYATL2
uniprot id: A0A480RNZ5
uniprot id: A0A8D0ZZF4
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9823:IER5
gene id: 9823:IER5
uniprot id: A0A287BB48
uniprot id: A0A8D2BYH6
names: Similarity
messages: Belongs to the IER family.

9823:NUF2
gene id: 9823:NUF2
uniprot id: A0A8D1JSG5
uniprot id: F1S216
names: Similarity
messages: Belongs to the NUF2 family.

9823:MINDY1
gene id: 9823:MINDY1
uniprot id: A0A8D0MHE0
uniprot id: F1SS98
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9823:TMSB15A
gene id: 9823:TMSB15A
uniprot id: A0A4X1W3Y1
uniprot id: I3LAC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9823:PITHD1
gene id: 9823:PITHD1
uniprot id: A0A4X1VZ34
uniprot id: I3L9H4
names: Similarity
messages: Belongs to the PITHD1 family.

9823:KDM3A
gene id: 9823:KDM3A
uniprot id: A0A286ZY67
uniprot id: A0A8D2C8R8
names: Subcellular Location Annotation
messages: Nucleus

9823:RPL19
gene id: 9823:RPL19
uniprot id: A0A8D0U758
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9823:LOC100525239
gene id: 9823:LOC100525239
uniprot id: F1RJD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:HDAC2
gene id: 9823:HDAC2
uniprot id: A0A4X1V7Y5
uniprot id: F1RZK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9823:CNOT2
gene id: 9823:CNOT2
uniprot id: A0A4X1W0T9
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9823:TRH
gene id: 9823:TRH
uniprot id: A0A4X1UCE1
uniprot id: F1SPI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9823:HORMAD1
gene id: 9823:HORMAD1
uniprot id: E2IUK4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Interacts with HORMAD2. Interacts with IHO1.
messages: Nucleus
messages: Phosphorylated at Ser-377 in a SPO11-dependent manner.
messages: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.

9823:VNN3
gene id: 9823:VNN3
uniprot id: A0A4X1V6L4
uniprot id: F1S3Q8
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9823:ACAT1
gene id: 9823:ACAT1
uniprot id: A0A286ZXW1
uniprot id: A0A4X1UUQ1
uniprot id: A0A4X1UYA6
uniprot id: I3LP02
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9823:C9H1orf27
gene id: 9823:C9H1orf27
uniprot id: A0A480EIY3
uniprot id: A0A8D1SCM1
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9823:CSF2
gene id: 9823:CSF2
uniprot id: Q29118
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).
messages: Secreted

9823:CD99L2
gene id: 9823:CD99L2
uniprot id: A0A4X1SYL9
uniprot id: A0A8D0TD07
uniprot id: F1RQ20
names: Similarity
messages: Belongs to the CD99 family.

9823:SF3B5
gene id: 9823:SF3B5
uniprot id: A0A4X1VPH8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9823:ANAPC5
gene id: 9823:ANAPC5
uniprot id: A0A480VKC1
uniprot id: A0A8D0X495
uniprot id: F1RNP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9823:WEE2
gene id: 9823:WEE2
uniprot id: A4PES0
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Continuous activation of WEE2 is a cause of meiotic failure of small oocytes. In mammals, oocytes with a diameter less than 80% of that of full-grown oocytes cannot start meiotic maturation (PubMed:19550110).
messages: Detected only in the oocytes throughout oocyte maturation period.
messages: Nucleus
messages: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
messages: Ovary-specific.
messages: Phosphorylation leads to increase its activity.

9823:CYGB
gene id: 9823:CYGB
uniprot id: A0A4X1UXM8
names: Similarity
messages: Belongs to the globin family.

9823:TAX1BP3
gene id: 9823:TAX1BP3
uniprot id: A0A8D0JTM9
uniprot id: M3TYU2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9823:LOC396905
gene id: 9823:LOC396905
uniprot id: P26461
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Inhibits acrosin.
messages: Secreted
messages: Seminal plasma.

9823:TAF9B
gene id: 9823:TAF9B
uniprot id: A0A4X1VWY8
uniprot id: I3LFP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9823:GPR3
gene id: 9823:GPR3
uniprot id: A0A4X1UBB1
uniprot id: F1STP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:LIMA1
gene id: 9823:LIMA1
uniprot id: B0KYV5
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity).
messages: Cell membrane
messages: Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus (By similarity).
messages: Cytoplasm
messages: Interacts with NPC1L1; bridges NPC1L1 with MYO5B. Interacts with MYO5B; bridges MYO5B with NPC1L1 (By similarity). Interacts with PXN; this complex stabilizes actin dynamics. Interacts with F-actin and G-actin (By similarity).
messages: Isoform 1 is expressed at low levels at embryonic day 33 (33 dpc) and in the adult. Isoform 2 is expressed abundantly throughout embryonic development with a peak at 65 dpc and is expressed at lower levels in the neonate and adult. Isoform 1 and isoform 2 are expressed at similar levels in the adult.
messages: Phosphorylation of the C-terminal region by MAPK1/MAPK3 reduces its association with F-actin and contributes to actin filament reorganization and enhances cell motility.
messages: Widely expressed. Highest levels of isoform 2 are expressed in lung, spleen and small intestine. Isoform 2 is expressed at higher levels than isoform 1 in most tissues except liver, fat and kidney. Isoform 1 and isoform 2 are expressed at low levels in skeletal muscle, heart, stomach and lymph.
messages: cytoskeleton
messages: focal adhesion

9823:WDR48
gene id: 9823:WDR48
uniprot id: A0A4X1TQ15
uniprot id: A0A4X1TUZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Endosome
messages: Late endosome

9823:LOC100737106
gene id: 9823:LOC100737106
uniprot id: A0A4X1TBR5
uniprot id: A0A5G2QUS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:APOH
gene id: 9823:APOH
uniprot id: A0A140TAK8
uniprot id: A0A286ZFW3
uniprot id: A0A4X1SSS9
uniprot id: A0A4X1SU46
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:HMOX2
gene id: 9823:HMOX2
uniprot id: A0A287B1I6
uniprot id: A0A4X1VMC1
uniprot id: A0A4X1VSV5
uniprot id: F1RK58
names: Similarity
messages: Belongs to the heme oxygenase family.

9823:SELP
gene id: 9823:SELP
uniprot id: Q29097
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:KRT12
gene id: 9823:KRT12
uniprot id: A0A8D1H2B2
uniprot id: F1RXG3
names: Similarity
messages: Belongs to the intermediate filament family.

9823:GIMAP2
gene id: 9823:GIMAP2
uniprot id: A0A4X1UYZ6
uniprot id: A0A4X1UZY9
uniprot id: A0A8D0YTQ6
uniprot id: F1SSJ4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9823:HIST1H2BD
gene id: 9823:HIST1H2BD
uniprot id: A0A4X1VJJ6
uniprot id: F2Z584
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:LOC100514252
gene id: 9823:LOC100514252
uniprot id: F1SK76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CAPN9
gene id: 9823:CAPN9
uniprot id: A0A8D0W3C4
names: Similarity
messages: Belongs to the peptidase C2 family.

9823:CSTF1
gene id: 9823:CSTF1
uniprot id: A0A4X1UMW2
uniprot id: A0A4X1UQZ6
uniprot id: A5GFW3
names: Subcellular Location Annotation
messages: Nucleus

9823:CYP19A3
gene id: 9823:CYP19A3
uniprot id: P79304
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
messages: Membrane
messages: Ovary.

9823:GAB2
gene id: 9823:GAB2
uniprot id: A0A8D1DHF3
uniprot id: M3VH87
names: Similarity
messages: Belongs to the GAB family.

9823:CAPZA2
gene id: 9823:CAPZA2
uniprot id: A0PFK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9823:SLC2A6
gene id: 9823:SLC2A6
uniprot id: A0A480L693
uniprot id: A0A4X1SZC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane

9823:SLC25A23
gene id: 9823:SLC25A23
uniprot id: A0A8D0SXR5
uniprot id: B2MUB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9823:DIMT1
gene id: 9823:DIMT1
uniprot id: A0A287A7N7
uniprot id: A0A4X1UU74
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9823:NPR2
gene id: 9823:NPR2
uniprot id: A0A8D1Z4Z6
uniprot id: Q1HGG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9823:LOC100622849
gene id: 9823:LOC100622849
uniprot id: A0A287AUS0
uniprot id: A0A4X1VCU3
names: Similarity
messages: Belongs to the centrin family.

9823:PIK3CG
gene id: 9823:PIK3CG
uniprot id: O02697
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by both the alpha and the beta-gamma G proteins following stimulation of G protein-coupled receptors (GPCRs). Activation by GPCRs is assisted by the regulatory subunits (PIK3R5 or PIK3R6) leading to the translocation from the cytosol to the plasma membrane and to kinase activation. When bound to PIK3R5 the PI3K activity of PIK3CG could be activated greater than 100-fold by the beta-gamma G proteins.
messages: Autophosphorylation at Ser-1101 has no effect on the phosphatidylinositol-4,5-bisphosphate 3-kinase activity.
messages: Belongs to the PI3/PI4-kinase family.
messages: Cell membrane
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with GRK2 through the PIK helical domain. Interaction with GRK2 is required for targeting to agonist-occupied receptor. Interacts with PDE3B; regulates PDE3B activity and thereby cAMP levels in cells. Interacts with TPM2. Interacts with EPHA8; regulates integrin-mediated cell adhesion to substrate. Interacts with HRAS; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity).
messages: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Required for B-lymphocyte development and signaling. Together with other PI3Ks are involved in the oxidative burst produced by neutrophils in response to chemotactic agents. Together with PIK3CD regulate neutrophil extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also h…

9823:SLITRK3
gene id: 9823:SLITRK3
uniprot id: A0A4X1VEX6
uniprot id: F1SH46
names: Similarity
messages: Belongs to the SLITRK family.

9823:MFSD1
gene id: 9823:MFSD1
uniprot id: A0A8D1L3C4
uniprot id: I3LIQ5
names: Subcellular Location Annotation
messages: Membrane

9823:PFKFB1
gene id: 9823:PFKFB1
uniprot id: A0A8D0ZVX6
uniprot id: A0A8D0ZX13
uniprot id: A0A8D1CTY6
uniprot id: B8XSK3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9823:CSNK1A1
gene id: 9823:CSNK1A1
uniprot id: A0A480VY41
uniprot id: A0A4X1T6B8
uniprot id: A0A4X1T845
uniprot id: A0A8D1DJ21
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:VPS28
gene id: 9823:VPS28
uniprot id: A0A4X1UQN2
uniprot id: K7GM88
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

9823:GBX1
gene id: 9823:GBX1
uniprot id: A0A287AZC2
names: Subcellular Location Annotation
messages: Nucleus

9823:AZU1
gene id: 9823:AZU1
uniprot id: P80015
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Elastase subfamily.
messages: Cytoplasmic granule membrane
messages: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin.

9823:HEXIM2
gene id: 9823:HEXIM2
uniprot id: A0A8D1MNY0
uniprot id: F1RR20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9823:TIMP3
gene id: 9823:TIMP3
uniprot id: A0A286ZZX3
uniprot id: A0A4X1T4A1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts with EFEMP1.
messages: extracellular matrix

9823:SLC39A12
gene id: 9823:SLC39A12
uniprot id: A0A287AFC5
uniprot id: A0A287AX53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9823:BOD1
gene id: 9823:BOD1
uniprot id: A0A4X1UDJ6
uniprot id: F1SJZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

9823:ALMS1
gene id: 9823:ALMS1
uniprot id: A0A4X1W1T2
uniprot id: A0A4X1W8W4
names: Subcellular Location Annotation
messages: centrosome

9823:DGKE
gene id: 9823:DGKE
uniprot id: A0A8D0NLU7
uniprot id: D0G6S2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9823:ETV1
gene id: 9823:ETV1
uniprot id: A0A286ZQS8
uniprot id: A0A286ZS29
uniprot id: A0A480UWD6
uniprot id: A0A4X1TH65
uniprot id: A0A4X1TLB8
uniprot id: A0A8D1YVE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:FAM216B
gene id: 9823:FAM216B
uniprot id: A0A287BMM3
uniprot id: A0A8D0ZJD7
uniprot id: A0A8D1LME1
uniprot id: F1RJX2
names: Similarity
messages: Belongs to the FAM216 family.

9823:USP21
gene id: 9823:USP21
uniprot id: A0A4X1VU06
uniprot id: F1S196
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:CD163
gene id: 9823:CD163
uniprot id: Q2VL90
names: Caution
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs (By similarity).
messages: After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
messages: Cell membrane
messages: Expressed in monocytes and macrophages. Detected only in one population of monocytes (CD163+) which is in advanced maturation stage.
messages: Interacts with CSNK2B.
messages: Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.
messages: It is uncertain whether Met-1 or Met-6 is the initiator.
messages: Phosphorylated.
messages: Secreted
messages: Suppressed when monocytes are differentiated towards dendritic cells by CSF1 and IL4.
messages: The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.

9823:CDK7
gene id: 9823:CDK7
uniprot id: A0A4X1UJB4
uniprot id: C9K505
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9823:TMEM50A
gene id: 9823:TMEM50A
uniprot id: A0A4X1VPG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9823:CDPF1
gene id: 9823:CDPF1
uniprot id: A0A4X1W3S6
uniprot id: F1SM77
names: Similarity
messages: Belongs to the CDPF1 family.

9823:GPN3
gene id: 9823:GPN3
uniprot id: A0A4X1TZI1
uniprot id: F1RNN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9823:EHD2
gene id: 9823:EHD2
uniprot id: A0A8D0QZ29
uniprot id: I3LD72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9823:INSIG1
gene id: 9823:INSIG1
uniprot id: A0A4X1U6V6
uniprot id: F1SHU4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9823:C2H19orf53
gene id: 9823:C2H19orf53
uniprot id: A0A4X1SJW1
uniprot id: F1SD77
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9823:NFIL3
gene id: 9823:NFIL3
uniprot id: A0A4X1SEN5
uniprot id: F1RN07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9823:PLK2
gene id: 9823:PLK2
uniprot id: A0A8D0PK30
uniprot id: F1SLJ2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9823:FIGNL1
gene id: 9823:FIGNL1
uniprot id: A0A4X1TAF1
uniprot id: I3LS61
names: Similarity
messages: Belongs to the AAA ATPase family.

9823:NR4A2
gene id: 9823:NR4A2
uniprot id: A0A287A395
uniprot id: A0A4X1VQG3
uniprot id: A0A4X1VR83
uniprot id: D7EZN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9823:HOXC5
gene id: 9823:HOXC5
uniprot id: A0A286ZNZ3
uniprot id: A0A4X1WAM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:ORMDL3
gene id: 9823:ORMDL3
uniprot id: A0A286ZIU3
uniprot id: A0A4X1UGJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

9823:EYA4
gene id: 9823:EYA4
uniprot id: A0A287AST8
uniprot id: A0A480SJS2
uniprot id: A0A4X1V744
uniprot id: A0A4X1VAD9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus

9823:GH1
gene id: 9823:GH1
uniprot id: F6M7Y8
uniprot id: Q28957
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9823:CACNG3
gene id: 9823:CACNG3
uniprot id: A0A287AXU2
uniprot id: A0A8D1A9M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9823:BRMS1L
gene id: 9823:BRMS1L
uniprot id: A0A4X1TCZ2
uniprot id: F2Z5N1
names: Subcellular Location Annotation
messages: Nucleus

9823:RAB3A
gene id: 9823:RAB3A
uniprot id: Q06AU3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Interacts with RIMS1 and RIMS2 (By similarity). Interacts with Rabphilin-3A/RPH3A and Rab effector Noc2/RPH3AL (By similarity). Interacts with SYTL4 (By similarity). Interacts with RAB3IP (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with SYT1 (By similarity). Interacts with MYH9; this interaction is essential for lysosome exocytosis and plasma membrane repair (By similarity). Interacts with STXBP1; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with SNCA (By similarity). Interacts with GDI1, GDI2, CHM and CHML; phosphorylation at Thr-86 disrupts these interactions (By similarity). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
messages: Lysosome
messages: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Postsynapse
messages: Presynapse
messages: Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity).
messages: axon
messages: cytosol
messages: secretory vesicle

9823:PCSK4
gene id: 9823:PCSK4
uniprot id: I3LT46
names: Similarity
messages: Belongs to the peptidase S8 family.

9823:LOC100514038
gene id: 9823:LOC100514038
uniprot id: A0A4X1UD02
uniprot id: F1RMY6
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9823:MTMR10
gene id: 9823:MTMR10
uniprot id: A0A287AMY3
uniprot id: A0A4X1UC99
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9823:VNN2
gene id: 9823:VNN2
uniprot id: A0A4X1V8P2
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9823:FGFR2
gene id: 9823:FGFR2
uniprot id: A0A4X1SP68
uniprot id: A5A754
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9823:SDHD
gene id: 9823:SDHD
uniprot id: A0A8D1GMP5
uniprot id: A5GZW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9823:HBEGF
gene id: 9823:HBEGF
uniprot id: Q01580
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity).
messages: Interacts with FBLN1. Interacts with EGFR and ERBB4 (By similarity).
messages: Macrophages, midbrain, cerebellum, hypothalamus, cerebral cortex, bulbourethral gland, lung, heart ventricle, kidney, skin, prostate, seminal vesicle, testis; at low levels in lymph node, thymus, spleen; not detected in pituitary, olfactory bulb, thyroid, duodenum, pancreas, liver, submaxillary gland.
messages: O-glycosylated.
messages: extracellular space

9823:HOXC13
gene id: 9823:HOXC13
uniprot id: A0A4X1WBW3
uniprot id: F1SFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9823:TICAM1
gene id: 9823:TICAM1
uniprot id: A0A4X1VS73
uniprot id: K9J6H0
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.
messages: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
messages: Mitochondrion
messages: The N-terminal region is essential for activation of the IFNB promoter activity.
messages: autophagosome
messages: cytosol

9823:TSPAN31
gene id: 9823:TSPAN31
uniprot id: A0A5G2R1G0
uniprot id: A0A8D0K2Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:GPR68
gene id: 9823:GPR68
uniprot id: A0A4X1SS50
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:CCL17
gene id: 9823:CCL17
uniprot id: A0A4X1UX34
uniprot id: G8XRI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:PRPS1L1
gene id: 9823:PRPS1L1
uniprot id: A0A287BHA2
uniprot id: A0A8D0TUK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9823:LMNA
gene id: 9823:LMNA
uniprot id: A0A287AE06
uniprot id: A0A8D1MMD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9823:SLA-1
gene id: 9823:SLA-1
uniprot id: A0A0A7BZR3
uniprot id: A1YH77
names: Similarity
messages: Belongs to the MHC class I family.

9823:RNF141
gene id: 9823:RNF141
uniprot id: A0A287AJU8
uniprot id: A0A4X1TXA8
names: Function
messages: May be involved in spermatogenesis.

9823:HSD3B1
gene id: 9823:HSD3B1
uniprot id: D0G6Y4
uniprot id: Q9N119
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
messages: Belongs to the 3-beta-HSD family.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane

9823:SEPT4
gene id: 9823:SEPT4
uniprot id: A0A173G6G4
uniprot id: A0A4X1SNK8
uniprot id: A0A8D1MMA0
uniprot id: A0A8D1WFP4
uniprot id: F1RRN6
uniprot id: K7GM78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:KEF22 p03
gene id: 9823:KEF22_p03
uniprot id: Q9TDR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9823:SLC30A3
gene id: 9823:SLC30A3
uniprot id: A0A4X1TL95
uniprot id: B6VAW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9823:POLD2
gene id: 9823:POLD2
uniprot id: A0A480YVX5
uniprot id: A0A8D0RNE6
uniprot id: A0A8D2CD08
uniprot id: F1SSF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9823:MTAP
gene id: 9823:MTAP
uniprot id: A0A8D0Y5V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9823:SEPT11
gene id: 9823:SEPT11
uniprot id: A0A173G6G6
uniprot id: A0A287AFS4
uniprot id: A0A4X1SW97
uniprot id: A0A8D1G7M0
uniprot id: A0A8D1TYU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:CDK1
gene id: 9823:CDK1
uniprot id: A0A8D1XTE4
uniprot id: C0SW08
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:LOC100623540
gene id: 9823:LOC100623540
uniprot id: A0A4X1VIM4
uniprot id: K7GP63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9823:MRPL10
gene id: 9823:MRPL10
uniprot id: A0A480VPY3
uniprot id: A0A8D0ZEZ5
uniprot id: A0A8D1CRL6
uniprot id: F1RWJ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

9823:GDAP1L1
gene id: 9823:GDAP1L1
uniprot id: A0A286ZNL7
uniprot id: A0A4X1TUY9
names: Similarity
messages: Belongs to the GST superfamily.

9823:IL19
gene id: 9823:IL19
uniprot id: A0A4X1UQI7
uniprot id: F1SEZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9823:KAT5
gene id: 9823:KAT5
uniprot id: A0A287BIK4
uniprot id: A0A480KLF9
uniprot id: A0A4X1ULG1
uniprot id: A0A5G2QX77
uniprot id: A0A8D0TM77
uniprot id: A0A8D1YRA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9823:PCOLCE
gene id: 9823:PCOLCE
uniprot id: A0A4X1UEE0
uniprot id: I3LEE6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:PGK2
gene id: 9823:PGK2
uniprot id: Q6RI85
uniprot id: X4ZHK0
names: Developmental Stage
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the phosphoglycerate kinase family.
messages: Contains at least 10 polymorphisms. Those that lead to amino acid substitutions may alter protein secondary structures and may influence male fertility.
messages: Cytoplasm
messages: Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis.
messages: Expression is highest in the adult, lower in a 10 month old and very weak in an 8 week old.
messages: Monomer.
messages: Testis specific.

9823:CDIPT
gene id: 9823:CDIPT
uniprot id: A0A8D2BU20
uniprot id: D0G6R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9823:LOC100516963
gene id: 9823:LOC100516963
uniprot id: A0A4X1VTC7
uniprot id: F1RHM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NMUR2
gene id: 9823:NMUR2
uniprot id: A0A060ILH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9823:GAL3ST3
gene id: 9823:GAL3ST3
uniprot id: A0A4X1UB24
uniprot id: I3LDC5
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9823:LOC100520543
gene id: 9823:LOC100520543
uniprot id: A0A4X1UND0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MBL2
gene id: 9823:MBL2
uniprot id: Q9XSW3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. According to some authors, it only binds mannose (PubMed:8602463).
messages: Expressed in liver. Weakly expressed in kidney and testis.
messages: Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity). Forms oligomeric complexes of 2 or 3 homotrimers.
messages: Secreted
messages: The coiled-coil domain mediates trimerization.

9823:TMEM35A
gene id: 9823:TMEM35A
uniprot id: A0A4X1W631
uniprot id: I3LKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane
messages: Vesicle

9823:DLL1
gene id: 9823:DLL1
uniprot id: A0A4X1VY27
uniprot id: A0A8D1AM37
uniprot id: I3LNT3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9823:SELENOT
gene id: 9823:SELENOT
uniprot id: C6JUQ1
names: Similarity
messages: Belongs to the SelWTH family. Selenoprotein T subfamily.

9823:IL18
gene id: 9823:IL18
uniprot id: O19073
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.

9823:ANXA4
gene id: 9823:ANXA4
uniprot id: D0G0C5
uniprot id: P08132
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
messages: Monomer.
messages: Seems to bind one calcium ion with high affinity.
messages: Zymogen granule membrane

9823:LGMN
gene id: 9823:LGMN
uniprot id: A0A287AW67
uniprot id: A0A4X1SMU4
names: Similarity
messages: Belongs to the peptidase C13 family.

9823:GSR
gene id: 9823:GSR
uniprot id: A0A8D1Q9F8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

9823:KLC2
gene id: 9823:KLC2
uniprot id: A0A480I2E4
uniprot id: A0A8D1RD32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9823:C1H14orf166
gene id: 9823:C1H14orf166
uniprot id: A0A4X1WD90
uniprot id: F1SFF4
names: Similarity
messages: Belongs to the RTRAF family.

9823:CCL20
gene id: 9823:CCL20
uniprot id: A0A8D1VMA7
uniprot id: Q5K4L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:PLOD1
gene id: 9823:PLOD1
uniprot id: A0A480M584
uniprot id: A0A4X1W845
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9823:EMC10
gene id: 9823:EMC10
uniprot id: A0A286ZQ46
uniprot id: A0A4X1VQ45
uniprot id: A0A8D0TX99
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC10 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9823:ELL2
gene id: 9823:ELL2
uniprot id: A0A480JTG5
uniprot id: A0A8D0NBL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9823:PLCB4
gene id: 9823:PLCB4
uniprot id: A0A287BD89
uniprot id: A0A4X1USY6
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9823:AUH
gene id: 9823:AUH
uniprot id: A0A4X1SE75
uniprot id: F1RN10
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9823:PPP3CA
gene id: 9823:PPP3CA
uniprot id: A0A8D1SEU2
uniprot id: Q95MZ3
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9823:APTX
gene id: 9823:APTX
uniprot id: Q7YRZ1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
messages: Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT/PARP1 and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated).
messages: The C2H2-type zinc finger mediates DNA-binding.
messages: The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4.
messages: The HIT domain is required for enzymatic activity.
messages: The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.
messages: nucleolus
messages: nucleoplasm

9823:UFL1
gene id: 9823:UFL1
uniprot id: A0A4X1VI90
names: Similarity
messages: Belongs to the UFL1 family.

9823:EARS2
gene id: 9823:EARS2
uniprot id: A0A287A262
uniprot id: F1SAB4
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9823:TRIP13
gene id: 9823:TRIP13
uniprot id: D3K5L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation (By similarity).
messages: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction (By similarity). Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (By similarity).

9823:LOC100522404
gene id: 9823:LOC100522404
uniprot id: F1SMT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

9823:TAPT1
gene id: 9823:TAPT1
uniprot id: A0A8D1B7C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

9823:UQCC
gene id: 9823:UQCC
uniprot id: A0A4X1T725
uniprot id: D3K5L2
names: Similarity
messages: Belongs to the CBP3 family.

9823:EIF2B2
gene id: 9823:EIF2B2
uniprot id: A0A4X1TA05
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9823:OLR1
gene id: 9823:OLR1
uniprot id: Q9TTK7
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70 (By similarity).
messages: Membrane raft
messages: N-glycosylated.
messages: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).
messages: Secreted
messages: The C-type lectin domain mediates the recognition and binding of oxLDL.
messages: The cytoplasmic region is required for subcellular sorting on the cell surface.

9823:CHL1
gene id: 9823:CHL1
uniprot id: A0A287ASJ8
uniprot id: A0A8D1A718
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9823:TMEM218
gene id: 9823:TMEM218
uniprot id: A0A4X1VJ85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9823:CYP19A2
gene id: 9823:CYP19A2
uniprot id: P79430
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
messages: Membrane

9823:GGT7
gene id: 9823:GGT7
uniprot id: A0A4X1T5T3
uniprot id: A0A8D0Q2X4
uniprot id: F1S4Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9823:NUDT18
gene id: 9823:NUDT18
uniprot id: A0A8D1BBQ9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9823:KIF3A
gene id: 9823:KIF3A
uniprot id: A0A4X1UWV9
uniprot id: A0A4X1UXZ4
uniprot id: A0A4X1UY17
uniprot id: A0A8D1PQB3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:WDR76
gene id: 9823:WDR76
uniprot id: A0A287BI34
uniprot id: A0A4X1VBN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9823:TTLL1
gene id: 9823:TTLL1
uniprot id: A0A480WXX7
uniprot id: A0A4X1W5I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin polyglutamylase family.
messages: cilium basal body

9823:RTCB
gene id: 9823:RTCB
uniprot id: Q19PY3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.
messages: Nucleus

9823:SLC25A43
gene id: 9823:SLC25A43
uniprot id: A0A4X1W0A8
uniprot id: K7GPX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:RBBP4
gene id: 9823:RBBP4
uniprot id: A0A5K1VU58
uniprot id: A0A8D2CA60
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100522928
gene id: 9823:LOC100522928
uniprot id: A0A4X1VVD4
uniprot id: F1RNC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CENPA
gene id: 9823:CENPA
uniprot id: A0A287A1W6
uniprot id: A0A4X1TU15
uniprot id: A0A8D1X6A6
names: Similarity
messages: Belongs to the histone H3 family.

9823:STAC
gene id: 9823:STAC
uniprot id: A0A480ZJP6
uniprot id: A0A8D0ZQV8
names: Subcellular Location Annotation
messages: sarcolemma

9823:TOX4
gene id: 9823:TOX4
uniprot id: A0A4X1UWA5
uniprot id: I3LAV9
names: Subcellular Location Annotation
messages: Nucleus

9823:ZKSCAN5
gene id: 9823:ZKSCAN5
uniprot id: A0A480HRD0
uniprot id: A0A8D1A6D1
uniprot id: A0A8D1S0Q8
names: Subcellular Location Annotation
messages: Nucleus

9823:MLF1
gene id: 9823:MLF1
uniprot id: A0A4X1SID5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9823:RPL23
gene id: 9823:RPL23
uniprot id: P62831
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:KRT4
gene id: 9823:KRT4
uniprot id: A0A8D1ZQ85
names: Similarity
messages: Belongs to the intermediate filament family.

9823:ZFP36L2
gene id: 9823:ZFP36L2
uniprot id: A0A287A4G1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9823:SMU1
gene id: 9823:SMU1
uniprot id: A0A4X1UMT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9823:ATP1B3
gene id: 9823:ATP1B3
uniprot id: A0A287B5A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9823:TTC38
gene id: 9823:TTC38
uniprot id: A0A480V890
uniprot id: A0A4X1W4N0
names: Similarity
messages: Belongs to the TTC38 family.

9823:MSANTD3
gene id: 9823:MSANTD3
uniprot id: A0A287B764
uniprot id: A0A4X1VB42
names: Similarity
messages: Belongs to the MSANTD3 family.

9823:TXLNG
gene id: 9823:TXLNG
uniprot id: A0A287BFL6
uniprot id: A0A8D1CR22
names: Similarity
messages: Belongs to the taxilin family.

9823:ELP1
gene id: 9823:ELP1
uniprot id: A0A480JST9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Cytoplasm

9823:EMP3
gene id: 9823:EMP3
uniprot id: A0A4X1W1Y8
uniprot id: I3LIF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9823:ATP4A
gene id: 9823:ATP4A
uniprot id: P19156
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Down-regulated by K(+)-competitive acid blockers (P-CABs) such as vonoprazan.
messages: The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (PubMed:29618813, PubMed:31436534, PubMed:30143663, PubMed:19387495).
messages: The gastric H(+)/K(+) ATPase pump is composed of the catalytic alpha subunit ATP4A and the regulatory beta subunit ATP4B (PubMed:29618813, PubMed:19387495, PubMed:21224846). Interacts (via the P-domain) with ATP4B (via N-terminus); this interaction stabilizes the lumenal-open E2 conformation state and prevents the reverse reaction of the transport cycle (PubMed:19387495).

9823:REEP4
gene id: 9823:REEP4
uniprot id: A0A4X1VJ65
uniprot id: F1RMB6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:LACC1
gene id: 9823:LACC1
uniprot id: A0A4X1SDE6
uniprot id: F1RJX9
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9823:CD46
gene id: 9823:CD46
uniprot id: O02839
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Broadly expressed. Expressed on erythrocytes, leukocytes, granulocytes, platelets, vascular endothelial cells and kidney epithelial cells. Not or weakly expressed in muscle cells and skin (at protein level).
messages: Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN.
messages: May be O-glycosylated.
messages: N-glycosylated.
messages: acrosome inner membrane

9823:CDX1
gene id: 9823:CDX1
uniprot id: A0A480JPE6
uniprot id: A0A8D0T324
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9823:EPN3
gene id: 9823:EPN3
uniprot id: A0A480DGA7
uniprot id: A0A8D1A739
uniprot id: A0A8D1E1K3
uniprot id: F1RT98
names: Similarity
messages: Belongs to the epsin family.

9823:SETDB1
gene id: 9823:SETDB1
uniprot id: A0A4X1SEN2
uniprot id: F1SS95
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9823:YIPF1
gene id: 9823:YIPF1
uniprot id: A0A287ASC2
uniprot id: A0A8D0XZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9823:UNC5B
gene id: 9823:UNC5B
uniprot id: A0A286ZIM0
uniprot id: Q2HXW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9823:CYP4A21
gene id: 9823:CYP4A21
uniprot id: Q9GJX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the 6 alpha hydroxylation oxidation of taurodeoxycholate to produce the pig specific bile acid taurohyocholic acid.
messages: Endoplasmic reticulum membrane
messages: Primarily expressed in liver. Low expression in kidney.

9823:MTIF2
gene id: 9823:MTIF2
uniprot id: A0A4X1WBZ8
uniprot id: F1SQK6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9823:MCL1
gene id: 9823:MCL1
uniprot id: A0A4X1SFB1
uniprot id: K9IWB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

9823:RNFT2
gene id: 9823:RNFT2
uniprot id: A0A4X1TS62
uniprot id: F1RKE5
names: Subcellular Location Annotation
messages: Membrane

9823:TNNT1
gene id: 9823:TNNT1
uniprot id: A0A4X1V7C9
uniprot id: Q75ZZ6
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9823:MED10
gene id: 9823:MED10
uniprot id: A0A4X1TKI3
uniprot id: A0A8D1BGW3
uniprot id: F1S049
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:AOC2
gene id: 9823:AOC2
uniprot id: A0A480WBC5
uniprot id: A0A4X1TX67
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9823:CTNNBL1
gene id: 9823:CTNNBL1
uniprot id: I1SNT7
names: Subcellular Location Annotation
messages: Nucleus

9823:CLDN9
gene id: 9823:CLDN9
uniprot id: C3VMK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:C15H2orf88
gene id: 9823:C15H2orf88
uniprot id: A0A287ABE0
uniprot id: A0A4X1TIH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9823:TMEM200A
gene id: 9823:TMEM200A
uniprot id: A0A8D1A8T7
uniprot id: F1S3M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9823:FABP5
gene id: 9823:FABP5
uniprot id: A0A8D1FBA5
uniprot id: Q19KE2
uniprot id: Q2EN74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9823:GSPT2
gene id: 9823:GSPT2
uniprot id: A0A8D1ZRZ1
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9823:EGR1
gene id: 9823:EGR1
uniprot id: A0A8D0NAP9
uniprot id: F1RH73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9823:KCTD10
gene id: 9823:KCTD10
uniprot id: F1RGB8
names: Similarity
messages: Belongs to the BACURD family.

9823:ELOA
gene id: 9823:ELOA
uniprot id: A0A8D1FSM7
names: Subcellular Location Annotation
messages: Nucleus

9823:TAF4B
gene id: 9823:TAF4B
uniprot id: A0A480NM35
uniprot id: A0A4X1VMX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

9823:TNS4
gene id: 9823:TNS4
uniprot id: A0A8D0S2E2
uniprot id: F1RXE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9823:FTL
gene id: 9823:FTL
uniprot id: A0A8D1HA22
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9823:RPL3
gene id: 9823:RPL3
uniprot id: A0A287B5V1
uniprot id: Q29293
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Component of the large ribosomal subunit. Interacts with DHX33.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Constitutively monomethylated at His-245 by METTL18. Methylation at His-245 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins It is not required for incorporation of RPL3 into ribosomes.
messages: Cytoplasm
messages: nucleolus

9823:RBM5
gene id: 9823:RBM5
uniprot id: A0A480DPP4
uniprot id: A0A4X1SMW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9823:FMO5
gene id: 9823:FMO5
uniprot id: A0A480S6J5
uniprot id: A0A4X1SM21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9823:GGTA1P
gene id: 9823:GGTA1P
uniprot id: A0A4X1UM53
uniprot id: P50127
uniprot id: Q548W5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Golgi stack membrane
messages: Membrane
messages: Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isogloboside 3 (iGb3) (By similarity).
messages: The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.

9823:PTGR2
gene id: 9823:PTGR2
uniprot id: A0A480YV73
uniprot id: A0A4X1TM83
uniprot id: F1S3H7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9823:PIAS3
gene id: 9823:PIAS3
uniprot id: A0A8D0JEB5
uniprot id: A0A8D0JEF8
uniprot id: F1SDD9
names: Similarity
messages: Belongs to the PIAS family.

9823:LOC100511243
gene id: 9823:LOC100511243
uniprot id: A0A4X1VJ02
uniprot id: F1RMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SETDB2
gene id: 9823:SETDB2
uniprot id: A0A4X1SKC6
uniprot id: A0A8D0VN34
uniprot id: F1RK20
names: Subcellular Location Annotation
messages: Chromosome

9823:TMEFF1
gene id: 9823:TMEFF1
uniprot id: A0A287BBI1
uniprot id: A0A4X1VEZ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:SEPT8
gene id: 9823:SEPT8
uniprot id: A0A4X1UVE4
uniprot id: A0A4X1UX86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Presynapse
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: synaptic vesicle membrane

9823:PTBP1
gene id: 9823:PTBP1
uniprot id: A0A8D0J3K9
uniprot id: Q29099
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Monomer. Part of a ternary complex containing KHSRP, PTBP1, PTBP2 and HNRPH1. Interacts with RAVER1 and SFPQ (By similarity).
messages: Nucleus
messages: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.

9823:TMEM63B
gene id: 9823:TMEM63B
uniprot id: A0A8D2A5R9
uniprot id: K7GP08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9823:NLN
gene id: 9823:NLN
uniprot id: A0A480E8P3
uniprot id: Q02038
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.
messages: Mitochondrion
messages: Predominantly expressed in the liver, kidney and adrenal gland.
messages: Truncated due to inclusion of exon 4 which leads to premature stop codon.

9823:LOC396790
gene id: 9823:LOC396790
uniprot id: A0A287AX70
uniprot id: A0A8D0W8T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GMFG
gene id: 9823:GMFG
uniprot id: A0A4X1SWK9
uniprot id: F1SEH2
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9823:LOC100522507
gene id: 9823:LOC100522507
uniprot id: A0A5G2R682
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:IL27
gene id: 9823:IL27
uniprot id: Q5S1V9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of pro-inflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses pro-inflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 …
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with EBI3; not disulfide-linked. This heterodimer is known as interleukin IL-27 (By similarity).
messages: O-glycosylated.
messages: Secreted

9823:SLC5A5
gene id: 9823:SLC5A5
uniprot id: A0A8D1EXN7
uniprot id: Q9GJX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9823:TMED7
gene id: 9823:TMED7
uniprot id: A0A286ZPD7
uniprot id: A0A4X1U186
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9823:MELK
gene id: 9823:MELK
uniprot id: A0A480JCS7
uniprot id: A0A8D2BLP3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9823:TSPAN3
gene id: 9823:TSPAN3
uniprot id: A0A4X1TT86
uniprot id: F1SJ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:KDM5C
gene id: 9823:KDM5C
uniprot id: A0A8D1CN82
uniprot id: A1YVX4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the JARID1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Both the JmjC domain and the JmjN domain are required for enzymatic activity.
messages: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity).
messages: Nucleus
messages: Part of two distinct complexes, one containing E2F6, and the other containing REST.
messages: The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.

9823:AVPI1
gene id: 9823:AVPI1
uniprot id: A0A286ZYA1
uniprot id: A0A4X1U7V0
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9823:LOC100152475
gene id: 9823:LOC100152475
uniprot id: A0A4X1ULM2
uniprot id: F1SLP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RSAD1
gene id: 9823:RSAD1
uniprot id: A0A8D1PHX3
uniprot id: F1RT95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Mitochondrion

9823:LOC100626247
gene id: 9823:LOC100626247
uniprot id: A0A480NGB4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:CCDC93
gene id: 9823:CCDC93
uniprot id: A0A480VUG9
uniprot id: A0A8D1MA69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC93 family.
messages: Early endosome

9823:MED30
gene id: 9823:MED30
uniprot id: A0A287B0L2
uniprot id: A0A4X1T8L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9823:POLM
gene id: 9823:POLM
uniprot id: A0A4X1UIK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9823:ARF3
gene id: 9823:ARF3
uniprot id: C4MRC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9823:ZNF280C
gene id: 9823:ZNF280C
uniprot id: A0A286ZVJ5
uniprot id: A0A287B4J6
uniprot id: A0A480TFL2
uniprot id: A0A4X1W9E4
uniprot id: A0A8D0TCN6
uniprot id: A0A8D1EGC8
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9823:GABARAP
gene id: 9823:GABARAP
uniprot id: A0A4X1V1R7
uniprot id: D7RA28
names: Similarity
messages: Belongs to the ATG8 family.

9823:SMARCA5
gene id: 9823:SMARCA5
uniprot id: A0A8D0JZG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9823:AQN-1
gene id: 9823:AQN-1
uniprot id: A0A4X1SHD7
uniprot id: Q4R0H3
names: Caution
names: Similarity
messages: Belongs to the spermadhesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:FAM58A
gene id: 9823:FAM58A
uniprot id: A0A4X1SU55
uniprot id: F1S2B1
names: Similarity
messages: Belongs to the cyclin family. Cyclin-like FAM58 subfamily.

9823:UQCR10
gene id: 9823:UQCR10
uniprot id: A0A4X1VD08
uniprot id: Q2EN79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9823:CORT
gene id: 9823:CORT
uniprot id: F1RIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9823:DNAJB12
gene id: 9823:DNAJB12
uniprot id: A0A8D0IPU6
uniprot id: A0A8D0IQ11
uniprot id: F1SU89
names: Subcellular Location Annotation
messages: Membrane

9823:PFN3
gene id: 9823:PFN3
uniprot id: A0A4X1SF04
uniprot id: K4IWU4
names: Similarity
messages: Belongs to the profilin family.

9823:FMC1
gene id: 9823:FMC1
uniprot id: A0A286ZX89
uniprot id: A0A4X1V8F5
names: Similarity
messages: Belongs to the FMC1 family.

9823:TMEM211
gene id: 9823:TMEM211
uniprot id: A0A4X1SLA6
uniprot id: F1RGA0
names: Subcellular Location Annotation
messages: Membrane

9823:ELK1
gene id: 9823:ELK1
uniprot id: A0A4X1T8E2
uniprot id: K7GQA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:DRD5
gene id: 9823:DRD5
uniprot id: F1S5G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:TCTN3
gene id: 9823:TCTN3
uniprot id: A0A8D1KRB3
uniprot id: A0A8D1TLP6
uniprot id: F1SC46
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9823:AHR
gene id: 9823:AHR
uniprot id: A0A0A1ERS1
names: Subcellular Location Annotation
messages: Cytoplasm

9823:SSR4
gene id: 9823:SSR4
uniprot id: A0A4X1T3L9
uniprot id: K7GK90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9823:IDH3A
gene id: 9823:IDH3A
uniprot id: A0A480YSS4
uniprot id: A0A8D0ZSH2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9823:TP53RK
gene id: 9823:TP53RK
uniprot id: A0A4X1U5G0
uniprot id: F1SBF6
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

9823:PLN
gene id: 9823:PLN
uniprot id: P61013
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer. Interacts with HAX1. Interact with ATP2A2; the inhibition decreases ATP2A2 Ca(2+) affinity. Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with S100A1 in a Ca(2+)-dependent manner.
messages: In elongated spermatids, proteolytically cleaved by SPPL2C which modulates intracellular Ca(2+) homeostasis.
messages: Membrane
messages: Mitochondrion membrane
messages: Palmitoylated by ZDHHC16, promoting formation of the homopentamer.
messages: Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes (By similarity).
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation.
messages: Sarcoplasmic reticulum membrane

9823:ALDH1B1
gene id: 9823:ALDH1B1
uniprot id: A0A8D1ZUR1
uniprot id: F1ST54
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9823:SLC7A10
gene id: 9823:SLC7A10
uniprot id: A0A4X1TRK2
uniprot id: F1RNW8
names: Subcellular Location Annotation
messages: Membrane

9823:RPS19BP1
gene id: 9823:RPS19BP1
uniprot id: A0A8D0VAM2
uniprot id: F1SR98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

9823:TMEM208
gene id: 9823:TMEM208
uniprot id: A0A4X1UNC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9823:VDAC3
gene id: 9823:VDAC3
uniprot id: Q29380
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner (By similarity).
messages: Membrane
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

9823:SMPX
gene id: 9823:SMPX
uniprot id: Q0MUU2
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the SMPX family.
messages: High level of expression found in the heart and skeletal muscle, a very low expression in the lung and spleen and no expression found in the liver, kidney, fat and brain.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.
messages: Shows a differential expression level in the skeletal muscle, the expression in 65-day embryos being higher than other stages.

9823:HSPE1
gene id: 9823:HSPE1
uniprot id: A0A8D1SY74
uniprot id: Q6WSP6
names: Similarity
messages: Belongs to the GroES chaperonin family.

9823:SRP14
gene id: 9823:SRP14
uniprot id: A0A4X1UT34
uniprot id: F1SS29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

9823:IL18RAP
gene id: 9823:IL18RAP
uniprot id: A0A8D0ZJQ9
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9823:IFN-DELTA-10
gene id: 9823:IFN-DELTA-10
uniprot id: A0A8D1PQZ3
uniprot id: C8CKC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:TRAPPC6B
gene id: 9823:TRAPPC6B
uniprot id: A0A287AWL8
uniprot id: A0A4X1SVM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9823:SLC9A6
gene id: 9823:SLC9A6
uniprot id: A0A481B7Y0
uniprot id: A0A4X1SEX9
uniprot id: A0A8D1S7I2
uniprot id: K7GPQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9823:MYOZ3
gene id: 9823:MYOZ3
uniprot id: Q1AG05
names: Similarity
messages: Belongs to the myozenin family.

9823:MMP11
gene id: 9823:MMP11
uniprot id: A0A4X1V105
uniprot id: A0A8D0MUM1
uniprot id: F1RL22
names: Similarity
messages: Belongs to the peptidase M10A family.

9823:YIPF5
gene id: 9823:YIPF5
uniprot id: A0A4X1SVT1
uniprot id: Q06AA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9823:SLC39A8
gene id: 9823:SLC39A8
uniprot id: A0A480EKF5
uniprot id: A0A8D0YLS2
names: Subcellular Location Annotation
messages: Membrane

9823:MAPK10
gene id: 9823:MAPK10
uniprot id: A0A4X1U0H3
uniprot id: A0A5G2R1U3
uniprot id: A0A8D1H850
uniprot id: A0A8D1K3D7
uniprot id: K7GT04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9823:GADD45G
gene id: 9823:GADD45G
uniprot id: A0A4X1SEY5
uniprot id: D3Y270
names: Similarity
messages: Belongs to the GADD45 family.

9823:ANGPTL4
gene id: 9823:ANGPTL4
uniprot id: Q2TNK5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain; both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell.
messages: Forms disulfide-linked dimers and tetramers.
messages: Homooligomer; disulfide-linked via Cys residues in the N-terminal part of the protein (By similarity). The homooligomer undergoes proteolytic processing to release the ANGPTL4 C-terminal chain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix (By similarity).
messages: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity).
messages: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.
messages: N-glycosylated.
messages: Secreted
messages: extracellular matrix

9823:NFATC1
gene id: 9823:NFATC1
uniprot id: O77638
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers (By similarity). Interacts with HOMER2 and HOMER3; this interaction may compete with calcineurin/PPP3CA-binding and hence prevent NFATC1 dephosphorylation and activation (By similarity). Interacts with TLE6/GRG6 (By similarity).
messages: Nucleus
messages: Phosphorylated by NFATC-kinase and GSK3B; phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1 (By similarity).
messages: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.
messages: Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
messages: The N-terminal transactivation domain (TAD-A) binds to and is activated by Cbp/p300. The dephosphorylated form contains two unmasked nuclear localization signals (NLS), which allow translocation of the protein to the nucleus (By similarity).

9823:VIL1
gene id: 9823:VIL1
uniprot id: A0A480TKM7
uniprot id: A0A4X1UFH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: filopodium tip
messages: lamellipodium
messages: microvillus
messages: ruffle

9823:LDB3
gene id: 9823:LDB3
uniprot id: A0A8D1YGQ1
names: Subcellular Location Annotation
messages: Z line

9823:MLLT11
gene id: 9823:MLLT11
uniprot id: A0A4X1W0E9
uniprot id: F1SSX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9823:EREG
gene id: 9823:EREG
uniprot id: A0A287A6I2
uniprot id: A0A4X1T4H4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MARCH4
gene id: 9823:MARCH4
uniprot id: A0A8D0W1I2
uniprot id: F1SS21
names: Subcellular Location Annotation
messages: Membrane

9823:WNT11
gene id: 9823:WNT11
uniprot id: A0A5G2QZA2
uniprot id: A0A8D1MKJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:CEP162
gene id: 9823:CEP162
uniprot id: A0A287A8A2
uniprot id: A0A287BD77
uniprot id: F1S0I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

9823:DNAAF2
gene id: 9823:DNAAF2
uniprot id: A0A8D1QI77
uniprot id: F1SHZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

9823:LOC100513411
gene id: 9823:LOC100513411
uniprot id: A0A8D1ACZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100522475
gene id: 9823:LOC100522475
uniprot id: A0A8D1XR14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100628183
gene id: 9823:LOC100628183
uniprot id: A0A5G2R808
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SELL
gene id: 9823:SELL
uniprot id: A0A8D0IG50
uniprot id: A8R080
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:GJA10
gene id: 9823:GJA10
uniprot id: A0A480DJL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:SMIM22
gene id: 9823:SMIM22
uniprot id: A0A4X1VTF1
names: Subcellular Location Annotation
messages: Membrane

9823:STAT5B
gene id: 9823:STAT5B
uniprot id: Q9TUZ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcription factor STAT family.
messages: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
messages: Cytoplasm
messages: Nucleus
messages: Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.
messages: Upon activation, forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1. Interacts with NMI. Interacts with SOCS7. Interacts (via SH2 domain) with INSR. Interacts with CPEB3; this inhibits STAT5B-mediated transcriptional activation.

9823:APC2
gene id: 9823:APC2
uniprot id: F2X0U7
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9823:CDC5L
gene id: 9823:CDC5L
uniprot id: A0A4X1V455
uniprot id: F1RQS5
names: Similarity
messages: Belongs to the CEF1 family.

9823:AFF4
gene id: 9823:AFF4
uniprot id: A0A4X1UXX1
uniprot id: I3L7N2
names: Similarity
messages: Belongs to the AF4 family.

9823:ARMT1
gene id: 9823:ARMT1
uniprot id: A0A480QLZ8
uniprot id: A0A4X1VQN2
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9823:CS
gene id: 9823:CS
uniprot id: P00889
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Homodimer.
messages: Methylated (PubMed:7093227). Trimethylation at Lys-395 by CSKMT decreases citrate synthase activity (By similarity).
messages: Mitochondrion matrix

9823:FOXN2
gene id: 9823:FOXN2
uniprot id: A0A4X1SF11
uniprot id: I3LTD2
names: Subcellular Location Annotation
messages: Nucleus

9823:ODC1
gene id: 9823:ODC1
uniprot id: A0A4X1UED3
uniprot id: B2CPJ8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9823:NBR1
gene id: 9823:NBR1
uniprot id: A0A287AEQ4
uniprot id: A0A287AM12
uniprot id: A0A287BC52
uniprot id: A0A4X1TQ30
uniprot id: A0A4X1TSF3
uniprot id: A0A4X1TV29
uniprot id: A0A4X1TV42
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9823:RING1
gene id: 9823:RING1
uniprot id: A0A4X1UU36
uniprot id: A5D9P0
names: Function
names: Subcellular Location Annotation
messages: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
messages: Nucleus speckle

9823:CACNB1
gene id: 9823:CACNB1
uniprot id: A0A287B082
uniprot id: A0A287B2Z1
uniprot id: A0A8D0YVF0
uniprot id: A0A8D1JH61
uniprot id: A0A8D1W431
uniprot id: F1RWK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Membrane
messages: sarcolemma

9823:GUK1
gene id: 9823:GUK1
uniprot id: A0A8D0XKL3
names: Similarity
messages: Belongs to the guanylate kinase family.

9823:BRCC3
gene id: 9823:BRCC3
uniprot id: A0A480V5W3
uniprot id: A0A4X1T8A2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9823:RCL1
gene id: 9823:RCL1
uniprot id: A0A4X1W823
uniprot id: A0A5G2QY97
uniprot id: A0A5G2R2D8
uniprot id: A0A8D1HPQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

9823:LOC100152722
gene id: 9823:LOC100152722
uniprot id: A0A286ZR64
uniprot id: A0A8D2C8U8
uniprot id: F1RK64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9823:GDF10
gene id: 9823:GDF10
uniprot id: A0A4X1VFY0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9823:GPR20
gene id: 9823:GPR20
uniprot id: A0A4X1SH50
uniprot id: I3LP87
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:ARG1
gene id: 9823:ARG1
uniprot id: A0A480QN87
uniprot id: Q95JC8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Homotrimer (By similarity). Interacts with CMTM6 (By similarity).

9823:CDK2
gene id: 9823:CDK2
uniprot id: A0A4X1W3W2
uniprot id: A0A4X1W9B6
uniprot id: A0A4X1W9I0
uniprot id: A0A5G2QRI3
uniprot id: U3M3E7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:SLC8A3
gene id: 9823:SLC8A3
uniprot id: A0A287A5R3
uniprot id: A0A287ANZ5
uniprot id: A0A287BCG8
uniprot id: A0A4X1TYI8
uniprot id: A0A4X1TYK9
uniprot id: A0A4X1U198
uniprot id: A0A4X1U456
uniprot id: F1S4A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9823:SLC29A1
gene id: 9823:SLC29A1
uniprot id: A0A8D1I3Q2
uniprot id: A0A8D1L104
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9823:DKK2
gene id: 9823:DKK2
uniprot id: A0A287AN69
uniprot id: A0A4X1UUA8
names: Similarity
messages: Belongs to the dickkopf family.

9823:SLC16A5
gene id: 9823:SLC16A5
uniprot id: A0A287AB15
uniprot id: A0A4X1V462
uniprot id: K9J6H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9823:PSMD8
gene id: 9823:PSMD8
uniprot id: A0A287B5Q7
uniprot id: A0A4X1T8R9
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

9823:ITPR3
gene id: 9823:ITPR3
uniprot id: A0A8D0YAW7
uniprot id: A0A8D1Z485
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9823:MMD2
gene id: 9823:MMD2
uniprot id: A0A8D0RKU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:SMARCAD1
gene id: 9823:SMARCAD1
uniprot id: A0A4X1UE56
names: Subcellular Location Annotation
messages: Chromosome

9823:MPPE1
gene id: 9823:MPPE1
uniprot id: A0A481B239
uniprot id: A0A8D1W5F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9823:NFIB
gene id: 9823:NFIB
uniprot id: A0A286ZNP3
uniprot id: A0A4X1WAI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9823:MID1IP1
gene id: 9823:MID1IP1
uniprot id: A0A4X1VGT7
uniprot id: F1RXQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9823:SLC44A1
gene id: 9823:SLC44A1
uniprot id: A0A4X1VDR5
uniprot id: A0A8D0YAM6
uniprot id: K7GL05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9823:MFAP2
gene id: 9823:MFAP2
uniprot id: A0A4X1W8I2
uniprot id: F1SUS0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:TTR
gene id: 9823:TTR
uniprot id: P50390
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transthyretin family.
messages: Detected in plasma and cerebrospinal fluid (at protein level). Highly expressed in the choroid plexus. Detected in liver.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9823:FMOD
gene id: 9823:FMOD
uniprot id: A0A4X1V4X8
uniprot id: F1S6B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

9823:CRSP-2
gene id: 9823:CRSP-2
uniprot id: Q766Y7
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calcitonin family.
messages: Mainly expressed in the thyroid gland and CNS. Found in the nerve cells of the cerebrum, hippocampus, hypothalamus, pons/midbrain and thalamus. Also detected in the glia-like cells of pons/midbrain and in meninx of tactus opticus.
messages: Secreted

9823:AKAP8L
gene id: 9823:AKAP8L
uniprot id: A0A480SCR1
uniprot id: A0A4X1VLL8
uniprot id: F1SA03
names: Similarity
messages: Belongs to the AKAP95 family.

9823:LOC100622230
gene id: 9823:LOC100622230
uniprot id: A0A4X1V3S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CTSF
gene id: 9823:CTSF
uniprot id: A0A480TE38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9823:ATP7A
gene id: 9823:ATP7A
uniprot id: A0A4X1SGI5
uniprot id: A0A4X1SGS3
uniprot id: A0A5K1U0J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9823:COG8
gene id: 9823:COG8
uniprot id: A0A4X1SFA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG8 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:SNX13
gene id: 9823:SNX13
uniprot id: A0A4X1TF12
uniprot id: I3LUU8
names: Similarity
messages: Belongs to the sorting nexin family.

9823:ELOF1
gene id: 9823:ELOF1
uniprot id: A0A8D1B522
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9823:LOC106507488
gene id: 9823:LOC106507488
uniprot id: F1SQE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FAM83B
gene id: 9823:FAM83B
uniprot id: A0A8D0M4K5
uniprot id: F1RZW2
names: Similarity
messages: Belongs to the FAM83 family.

9823:PALMD
gene id: 9823:PALMD
uniprot id: A0A480JY98
uniprot id: Q2MJV9
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the paralemmin family.
messages: Cytoplasm
messages: Interacts with GLUL (By similarity). Cell projection, dendrite. Cell projection, dendritic spine (By similarity).
messages: Phosphorylated.
messages: dendrite
messages: dendritic spine

9823:SEPT6
gene id: 9823:SEPT6
uniprot id: A0A173G6H1
uniprot id: A0A4X1W0C9
uniprot id: A0A4X1W6F6
uniprot id: K7GS25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:SUGT1
gene id: 9823:SUGT1
uniprot id: A0A286ZQC1
uniprot id: A0A4X1V9C5
names: Similarity
messages: Belongs to the SGT1 family.

9823:RBFOX2
gene id: 9823:RBFOX2
uniprot id: A0A480LBN6
uniprot id: A0A480R3E1
uniprot id: A0A4X1TT75
uniprot id: A0A4X1TTR6
uniprot id: A0A8D1FQN1
uniprot id: A0A8D1FRH7
uniprot id: A0A8D1V6T6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9823:LOC100623714
gene id: 9823:LOC100623714
uniprot id: A0A4X1TV26
uniprot id: A0A5G2QMA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100524508
gene id: 9823:LOC100524508
uniprot id: A0A4X1TGR8
uniprot id: F1S7G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CDC42SE1
gene id: 9823:CDC42SE1
uniprot id: A0A287BD30
uniprot id: A0A4X1W1R4
uniprot id: A0A4X1W2X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9823:TSPYL2
gene id: 9823:TSPYL2
uniprot id: A0A4X1T268
uniprot id: A0A8D2CBR6
uniprot id: F1RUI4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9823:A4GALT
gene id: 9823:A4GALT
uniprot id: A0A8D1KT09
uniprot id: I3L755
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9823:NOP56
gene id: 9823:NOP56
uniprot id: A0A4X1SJ12
uniprot id: F1S895
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9823:ATP5G3
gene id: 9823:ATP5G3
uniprot id: A0A286ZIA7
uniprot id: A0A4X1UFJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9823:LOC100523672
gene id: 9823:LOC100523672
uniprot id: A0A4X1UME9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9823:LOC100518267
gene id: 9823:LOC100518267
uniprot id: A0A4X1SHH2
uniprot id: A0A5G2QFL3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:C14H10orf53
gene id: 9823:C14H10orf53
uniprot id: A0A4X1VAW3
uniprot id: F1SDW7
names: Similarity
messages: Belongs to the UPF0728 family.

9823:ENO3
gene id: 9823:ENO3
uniprot id: B1A3A0
uniprot id: Q1KYT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration.
messages: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. Interacts with PNKD (By similarity).
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.

9823:CHST7
gene id: 9823:CHST7
uniprot id: A0A480YBV2
uniprot id: A0A4X1SJU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9823:CDKN2AIPNL
gene id: 9823:CDKN2AIPNL
uniprot id: A0A287ACW8
uniprot id: A0A4X1UZX5
names: Similarity
messages: Belongs to the CARF family.

9823:PGLYRP2
gene id: 9823:PGLYRP2
uniprot id: Q866Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
messages: Membrane
messages: Secreted

9823:MSMO1
gene id: 9823:MSMO1
uniprot id: Q6UGB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol.
messages: Endoplasmic reticulum membrane
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

9823:SLITRK2
gene id: 9823:SLITRK2
uniprot id: A0A8D1DP42
uniprot id: F1RQ61
names: Similarity
messages: Belongs to the SLITRK family.

9823:C16H5orf22
gene id: 9823:C16H5orf22
uniprot id: A0A480Y8G2
uniprot id: A0A4X1TIX6
names: Similarity
messages: Belongs to the UPF0489 family.

9823:TMPRSS15
gene id: 9823:TMPRSS15
uniprot id: P98074
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Heterotrimer of a catalytic (light) chain, a multidomain (heavy) chain, and a mini chain.
messages: Membrane
messages: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
messages: The chains are derived from a single precursor that is cleaved by a trypsin-like protease.
messages: The mini chain may be cleaved by elastase.

9823:PHLDA2
gene id: 9823:PHLDA2
uniprot id: A0A4X1U8H0
uniprot id: D3Y268
names: Subcellular Location Annotation
messages: Cytoplasm

9823:ZDHHC22
gene id: 9823:ZDHHC22
uniprot id: A0A4X1T7S0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:CARNMT1
gene id: 9823:CARNMT1
uniprot id: A0A8D2A6D9
uniprot id: F1SJA3
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

9823:SERPINB2
gene id: 9823:SERPINB2
uniprot id: A0A4X1TSN7
uniprot id: F1SMW7
names: Similarity
messages: Belongs to the serpin family.

9823:SERINC5
gene id: 9823:SERINC5
uniprot id: A0A4X1T661
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

9823:AVP
gene id: 9823:AVP
uniprot id: P01183
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A shorter neurophysin molecule (32-123) is called neurophysin-I and is derived from the complete protein (called neurophysin III) by proteolytic degradation (in vivo or after extraction).
messages: Belongs to the vasopressin/oxytocin family.
messages: Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (By similarity). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (By similarity).
messages: Neurophysin 2 specifically binds vasopressin.
messages: Secreted
messages: Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (By similarity).

9823:CHRM3
gene id: 9823:CHRM3
uniprot id: P11483
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Homodimer; the dimers can form tetramers (By similarity). Interacts with NALCN (By similarity). Interacts with TMEM147 (By similarity).
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9823:LOC100738056
gene id: 9823:LOC100738056
uniprot id: A0A8D0NPF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9823:PLAC8
gene id: 9823:PLAC8
uniprot id: A0A287BG98
uniprot id: A0A8D0M0Q8
names: Similarity
messages: Belongs to the cornifelin family.

9823:CSN1S1
gene id: 9823:CSN1S1
uniprot id: B5KLC3
uniprot id: P39035
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9823:MDFIC
gene id: 9823:MDFIC
uniprot id: A0A4X1W5Z4
uniprot id: F1SJC4
names: Similarity
messages: Belongs to the MDFI family.

9823:PICALM
gene id: 9823:PICALM
uniprot id: A0A4X1U4B2
uniprot id: F8T0U2
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9823:MS4A5
gene id: 9823:MS4A5
uniprot id: I3LLV9
names: Similarity
messages: Belongs to the MS4A family.

9823:UBA3
gene id: 9823:UBA3
uniprot id: A0A4X1VAU4
uniprot id: A0A4X1VBU5
uniprot id: A0A4X1VDC4
uniprot id: A0A5G2QVD2
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9823:LOC100520317
gene id: 9823:LOC100520317
uniprot id: A0A480XK12
uniprot id: A0A4X1T8A9
uniprot id: A0A8D0LZN4
uniprot id: F1RUN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9823:ASIP
gene id: 9823:ASIP
uniprot id: A0A8D1HAG1
uniprot id: I3W8V4
uniprot id: Q6ZYM3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
messages: Secreted
messages: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

9823:DPM1
gene id: 9823:DPM1
uniprot id: A0A480VTP7
uniprot id: A0A8D1N733
uniprot id: A5GFZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Binds 1 divalent metal cation.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; within the complex, directly interacts with DPM3. This interaction may stabilize DPM1.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9823:KDM1B
gene id: 9823:KDM1B
uniprot id: A0A480TKW4
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9823:TAF5L
gene id: 9823:TAF5L
uniprot id: A0A4X1UAG2
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9823:SNRPD1
gene id: 9823:SNRPD1
uniprot id: A0A4X1VMY1
uniprot id: A0A4X1VQM0
uniprot id: F2Z5G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9823:MLST8
gene id: 9823:MLST8
uniprot id: A0A4X1VW75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9823:MYL4
gene id: 9823:MYL4
uniprot id: F1RRT2
names: Function
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: Regulatory light chain of myosin. Does not bind calcium.

9823:SPACA1
gene id: 9823:SPACA1
uniprot id: D5K8A9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Detected in spermatozoa (at protein level).
messages: N-glycosylated.
messages: Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility.
messages: acrosome inner membrane

9823:NDEL1
gene id: 9823:NDEL1
uniprot id: A0A286ZPG8
uniprot id: A0A480JJY5
uniprot id: A0A4X1V637
uniprot id: A0A4X1V9G4
uniprot id: A0A8D1JIE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9823:WDR83OS
gene id: 9823:WDR83OS
uniprot id: A0A5G2RMN9
uniprot id: A0A8D1HTP8
uniprot id: Q6Q7K0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Asterix family.
messages: Component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. WDR83OS/Asterix associates with the first transmembrane domain (TMD1) of the nascent chain, independently of the N-glycosylation of the chain and irrespective of the amino acid sequence and transmembrane topology of TMD1. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which TMD1 binds.
messages: Endoplasmic reticulum membrane
messages: Expressed during early cleavage-stage embryos before zygotic gene activation (ZGA), metaphase II (MII) oocyte, 1-cell, and 2-cell stage embryos.
messages: The PAT complex includes WDR83OS/Asterix and CCDC47.

9823:ITPA
gene id: 9823:ITPA
uniprot id: A0A480URB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9823:ENDOG
gene id: 9823:ENDOG
uniprot id: A0A4X1TPJ9
uniprot id: F1RR64
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9823:APOC4
gene id: 9823:APOC4
uniprot id: A0A4X1VWX4
uniprot id: D3Y266
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

9823:CPXM1
gene id: 9823:CPXM1
uniprot id: A0A480KGE1
uniprot id: A0A4X1SHD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9823:MRPL54
gene id: 9823:MRPL54
uniprot id: A0A480PHA9
uniprot id: A0A8D1ZYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9823:SLC22A3
gene id: 9823:SLC22A3
uniprot id: A0A4X1VVG5
uniprot id: F1SB80
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9823:ATP5A1
gene id: 9823:ATP5A1
uniprot id: P80021
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated on lysine residues. BLOC1S1 is required for acetylation.
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Expressed in heart (at protein level).
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1) (PubMed:1714390). CF(0) has three main subunits: a, b and c (By similarity). Interacts with ATPAF2. Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro). Interacts with PLG (angiostatin peptide); the interaction inhibits most of the angiogenic properties of angiostatin (By similarity). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficiency (By similarity). Interacts with CLN5 and PPT1 (By similarity). Interacts with S100A1; this interaction increases F1-ATPase activity (By similarity). Interacts with ABCB7; this interaction allows the regulation of cellular iron homeostasis and cellular reactive oxygen species (ROS) levels in cardiomyocytes (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: The siderophore enterobactin (Ent) produced by enteric bacteria binds Fe(3+) and helps bacteria scavenge iron ions from the environment. As a consequence, the mammalian siderocalin LCN2 plays an important role in defense against bacterial infections by sequestering iron bound to microbial siderophores. LCN2 can also bind iron bound to endogenous or nutrient-derived iron chelators and plays an important role in cellular iron homeostasis. Enterobactin produced by non-pathogenic E.coli strains can facilitate mitochondrial iron assimilation, suggesting that iron bound to siderophores from non-pathogenic bacteria may contribute to iron absorption by the host.

9823:PYGL
gene id: 9823:PYGL
uniprot id: B1A8Z3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9823:PPP1R10
gene id: 9823:PPP1R10
uniprot id: Q767K9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).
messages: Nucleus
messages: Phosphorylated on Thr-398 by PKA within the region necessary for interaction with PPP1CA.
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).

9823:RPE65
gene id: 9823:RPE65
uniprot id: A0A287BB78
uniprot id: A0A4X1U9R3
uniprot id: A0A4X1U9R8
uniprot id: F1S830
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9823:DNPEP
gene id: 9823:DNPEP
uniprot id: A0A480KKD6
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9823:SLC29A2
gene id: 9823:SLC29A2
uniprot id: A0A8D1AMS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9823:LDB1
gene id: 9823:LDB1
uniprot id: Q05KH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB family.
messages: Nucleus

9823:PLAC8L1
gene id: 9823:PLAC8L1
uniprot id: A0A8D0S5I1
uniprot id: F1RM19
names: Similarity
messages: Belongs to the cornifelin family.

9823:FAM53B
gene id: 9823:FAM53B
uniprot id: A0A480VS16
uniprot id: A0A4X1VAV3
names: Similarity
messages: Belongs to the FAM53 family.

9823:IFT20
gene id: 9823:IFT20
uniprot id: A0A480XEH4
uniprot id: A0A8D0MYT4
uniprot id: I3LK11
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9823:MIOS
gene id: 9823:MIOS
uniprot id: A0A4X1TNS1
uniprot id: D3K5M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9823:SKA1
gene id: 9823:SKA1
uniprot id: A0A4X1UKI5
uniprot id: F1RPP2
names: Similarity
messages: Belongs to the SKA1 family.

9823:USP44
gene id: 9823:USP44
uniprot id: A0A287AMI4
uniprot id: A0A4X1SJJ1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:NTHL1
gene id: 9823:NTHL1
uniprot id: A0A8D0NBU5
uniprot id: A0A8D0WQZ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

9823:RNASE4
gene id: 9823:RNASE4
uniprot id: P15468
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted
messages: This RNase has marked specificity towards the 3' side of uridine nucleotides.

9823:GAL3ST2
gene id: 9823:GAL3ST2
uniprot id: Q6XQG9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-3-O-sulfotransferase family.
messages: Golgi stack membrane
messages: Strongly inhibited by Cu(2+) and Zn(2+).
messages: Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency (By similarity).

9823:MSRB2
gene id: 9823:MSRB2
uniprot id: A0A4X1TRP8
uniprot id: F1RVI8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9823:IL12RB2
gene id: 9823:IL12RB2
uniprot id: A0A8D0UJX9
uniprot id: Q8MJS1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain (By similarity).
messages: Membrane
messages: On IL12 stimulation, phosphorylated on C-terminal tyrosine residues.
messages: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.

9823:ESCO1
gene id: 9823:ESCO1
uniprot id: A0A287B1A4
uniprot id: A0A4X1VNL4
names: Subcellular Location Annotation
messages: Nucleus

9823:TLE4
gene id: 9823:TLE4
uniprot id: A0A286ZQA3
uniprot id: A0A287BBZ3
uniprot id: A0A4X1VUV7
uniprot id: A0A4X1W1U4
uniprot id: A0A8D1GHS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9823:RER1
gene id: 9823:RER1
uniprot id: A0A4X1W361
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9823:KCNMB2
gene id: 9823:KCNMB2
uniprot id: A0A8D0YWB8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9823:LOC100624590
gene id: 9823:LOC100624590
uniprot id: A0A1B2TT47
uniprot id: A0A4X1VMU8
uniprot id: A0A4X1VQ11
uniprot id: I3LDV0
names: Similarity
messages: Belongs to the DEAD box helicase family.

9823:TUBA1B
gene id: 9823:TUBA1B
uniprot id: Q2XVP4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
messages: Belongs to the tubulin family.
messages: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (By similarity). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).
messages: Dimer of alpha and beta chains (PubMed:7225365). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Nascent tubulin polypeptide interacts (via beta-tubulin MREC motif) with TTC5/STRAP; this interaction may result in tubulin mRNA-targeted degradation.
messages: Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.
messages: Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREC motif mediates interaction with TTC5/STRAP and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:7225365). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:7225365). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:7225365).
messages: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules. In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).
messages: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (MATCAP, VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.
messages: cytoskeleton

9823:ELF4
gene id: 9823:ELF4
uniprot id: F1RTH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:UNKL
gene id: 9823:UNKL
uniprot id: A0A8D0R357
uniprot id: I3LAS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9823:AMH
gene id: 9823:AMH
uniprot id: A0A4X1VNC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
messages: Secreted

9823:CD48
gene id: 9823:CD48
uniprot id: A0A8D1WTL8
names: Subcellular Location Annotation
messages: Membrane

9823:NFIX
gene id: 9823:NFIX
uniprot id: A0A287A966
uniprot id: A0A4X1T887
uniprot id: A0A8D0M7Q6
uniprot id: A0A8D0NN11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9823:SULT1A3
gene id: 9823:SULT1A3
uniprot id: Q6Y0X5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:PSMB1
gene id: 9823:PSMB1
uniprot id: A0A287BPP9
uniprot id: A0A4X1VSI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:KARS
gene id: 9823:KARS
uniprot id: A0A287AKI9
uniprot id: A0A8D1ID99
uniprot id: F1S458
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9823:SL44-1
gene id: 9823:SL44-1
uniprot id: Q95JC9
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acinar cells and secretory granules of the parotid gland.
messages: Secreted
messages: The parotid hormone stimulates dentinal fluid transport in teeth.

9823:GALNT14
gene id: 9823:GALNT14
uniprot id: A0A4X1TER4
uniprot id: F1S3Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9823:FAM219A
gene id: 9823:FAM219A
uniprot id: A0A287AMI8
uniprot id: A0A8D1GDB7
names: Similarity
messages: Belongs to the FAM219 family.

9823:IPO13
gene id: 9823:IPO13
uniprot id: A0A8D0MN67
uniprot id: M3VK27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9823:ISM1
gene id: 9823:ISM1
uniprot id: A0A8D1S688
names: Similarity
messages: Belongs to the isthmin family.

9823:LOC100518575
gene id: 9823:LOC100518575
uniprot id: A0A8D0Y8Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9823:TMA16
gene id: 9823:TMA16
uniprot id: A0A4X1TTF1
uniprot id: F1RTW4
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9823:SENP1
gene id: 9823:SENP1
uniprot id: A0A287BK96
uniprot id: A0A8D1A7H7
uniprot id: A0A8D1C6A7
uniprot id: A0A8D1TGF0
uniprot id: F1SGU9
names: Similarity
messages: Belongs to the peptidase C48 family.

9823:UXS1
gene id: 9823:UXS1
uniprot id: A0A480TRQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

9823:APCS
gene id: 9823:APCS
uniprot id: O19063
names: Cofactor
names: Disease Annotation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
messages: Secreted

9823:TLR3
gene id: 9823:TLR3
uniprot id: A0A4X1VW92
uniprot id: A0ENH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9823:LIN52
gene id: 9823:LIN52
uniprot id: A0A8D0Y1X6
names: Similarity
messages: Belongs to the lin-52 family.

9823:PSME1
gene id: 9823:PSME1
uniprot id: Q64L94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PA28 family.
messages: Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers (By similarity).
messages: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity).

9823:PMEPA1
gene id: 9823:PMEPA1
uniprot id: A0A8D1C8F5
uniprot id: A5GFP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9823:BACE1
gene id: 9823:BACE1
uniprot id: A0A8D0JXI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: trans-Golgi network

9823:LOC100737597
gene id: 9823:LOC100737597
uniprot id: A0A4X1T8H3
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9823:WISP2
gene id: 9823:WISP2
uniprot id: A0A287BT12
uniprot id: A0A4X1TX21
names: Similarity
messages: Belongs to the CCN family.

9823:TAP2
gene id: 9823:TAP2
uniprot id: A0A8D1TYN8
uniprot id: A5D9J7
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9823:GBX2
gene id: 9823:GBX2
uniprot id: A0A4X1TAE5
uniprot id: F1SM11
names: Subcellular Location Annotation
messages: Nucleus

9823:PGR
gene id: 9823:PGR
uniprot id: D0EWS6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Nucleus
messages: Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues.

9823:FAM160B2
gene id: 9823:FAM160B2
uniprot id: F1RMC0
names: Similarity
messages: Belongs to the FHIP family.

9823:IFN-OMEGA-5
gene id: 9823:IFN-OMEGA-5
uniprot id: A0A4X1WC82
uniprot id: B3VSD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:MCUR1
gene id: 9823:MCUR1
uniprot id: A0A8D0X2Z0
uniprot id: A0A8D1E4U6
names: Similarity
messages: Belongs to the CCDC90 family.

9823:LALBA
gene id: 9823:LALBA
uniprot id: P18137
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
messages: Mammary gland specific. Secreted in milk.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
messages: Secreted
messages: The pig alpha-lactalbumin shows complete loss of both lysozyme functional residues.

9823:TMEM151A
gene id: 9823:TMEM151A
uniprot id: A0A4X1TSM4
uniprot id: F1RU42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9823:CPT1B
gene id: 9823:CPT1B
uniprot id: Q5US13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:NFYA
gene id: 9823:NFYA
uniprot id: A0A288CG16
uniprot id: A0A480VRR4
uniprot id: A0A480VU35
uniprot id: A0A4X1SMK0
uniprot id: A0A8D0K6M7
uniprot id: A0A8D0KHS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9823:LOC100623704
gene id: 9823:LOC100623704
uniprot id: A0A5G2R5V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NEDD8
gene id: 9823:NEDD8
uniprot id: A0A8D1I6C1
names: Similarity
messages: Belongs to the ubiquitin family.

9823:TMEM8A
gene id: 9823:TMEM8A
uniprot id: A0A8D0RDJ2
uniprot id: F1RGV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9823:PAQR3
gene id: 9823:PAQR3
uniprot id: A0A4X1SZW7
uniprot id: F1RVB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:SIX6
gene id: 9823:SIX6
uniprot id: A0A4X1WDX7
uniprot id: F1SSH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

9823:PNPLA4
gene id: 9823:PNPLA4
uniprot id: A0A8D1B072
uniprot id: A0A8D1J1J3
uniprot id: A0A8D1U918
uniprot id: C1KJN1
uniprot id: F1SG26
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:TRMT11
gene id: 9823:TRMT11
uniprot id: A0A481AJX3
uniprot id: A0A8D0MCI6
uniprot id: A0A8D1GUW1
uniprot id: A0A8D1XSA1
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

9823:NF2
gene id: 9823:NF2
uniprot id: A0A480KT19
uniprot id: A0A4X1V8X9
uniprot id: A0A8D0PJ78
uniprot id: A0A8D0U9C9
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9823:SLCO3A1
gene id: 9823:SLCO3A1
uniprot id: A0A287ASP2
uniprot id: A0A4X1UGL5
uniprot id: F1SCI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9823:SPACA4
gene id: 9823:SPACA4
uniprot id: A0A4X1W0P8
uniprot id: D5K890
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9823:SLC15A4
gene id: 9823:SLC15A4
uniprot id: A0A4X1UL43
uniprot id: A0A8D1ZMG7
uniprot id: I3LDX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

9823:ABHD5
gene id: 9823:ABHD5
uniprot id: Q5EE05
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase activity is inhibited by detergents such as Triton X-100 and 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS). Acyltransferase activity is inhibited by the presence of magnesium and calcium.
messages: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
messages: Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (By similarity). Involved in keratinocyte differentiation (By similarity). Regulates lipid droplet fusion (By similarity).
messages: Cytoplasm
messages: Interacts with ADRP, PLIN and PNPLA2. Interacts with PLIN5; promotes interaction with PNPLA2 (By similarity).
messages: Lipid droplet
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9823:AKIRIN1
gene id: 9823:AKIRIN1
uniprot id: A0A4X1VV46
uniprot id: B2CZF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9823:GPNMB
gene id: 9823:GPNMB
uniprot id: A0A4X1T4E9
uniprot id: A5A766
names: Similarity
messages: Belongs to the PMEL/NMB family.

9823:IFN-DELTA-8
gene id: 9823:IFN-DELTA-8
uniprot id: A0A4X1WCC1
uniprot id: I3LKN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:HSPA14
gene id: 9823:HSPA14
uniprot id: A0A5G2R1Z5
uniprot id: A0A8D1J6W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9823:FAM229B
gene id: 9823:FAM229B
uniprot id: A0A286ZZE4
uniprot id: A0A4X1VAF3
names: Similarity
messages: Belongs to the FAM229 family.

9823:UTP3
gene id: 9823:UTP3
uniprot id: B7TJ07
names: Similarity
messages: Belongs to the SAS10 family.

9823:HBE1
gene id: 9823:HBE1
uniprot id: P02101
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Hemoglobin epsilon chain is a beta-type chain found in early embryos.
messages: Red blood cells.

9823:COQ4
gene id: 9823:COQ4
uniprot id: A0A8D1SBE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9823:NQO1
gene id: 9823:NQO1
uniprot id: A0A4X1SHT1
uniprot id: F1S395
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9823:BCKDHA
gene id: 9823:BCKDHA
uniprot id: A0A4X1SK38
uniprot id: B1PK12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of alpha and beta chains.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

9823:MYO7A
gene id: 9823:MYO7A
uniprot id: A5A782
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9823:CTNNB1
gene id: 9823:CTNNB1
uniprot id: A0A4X1TKY9
uniprot id: Q8WNW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9823:PRRT1
gene id: 9823:PRRT1
uniprot id: A5A8Z9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:BASP1
gene id: 9823:BASP1
uniprot id: A0A287ALA0
uniprot id: A0A4X1TM42
names: Similarity
messages: Belongs to the BASP1 family.

9823:AMY2
gene id: 9823:AMY2
uniprot id: P00690
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 Cl(-) ion per subunit.
messages: Binds to the sea anemone inhibitor helianthamide and magnificamide.
messages: The two forms of this enzyme, I and II, show very similar activities, molecular masses, and compositions and differ only in their isoelectric points. As no evidence for two variants were in the cDNA library of PubMed:10082956, it is most likely that isoform I (PPAI) and isoform II (PPAII) are two forms of the same protein.
messages: extracellular space

9823:ANG
gene id: 9823:ANG
uniprot id: A0A8D0QG20
uniprot id: Q1HDU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9823:PFDN6
gene id: 9823:PFDN6
uniprot id: A0A4X1TGI0
uniprot id: A0A8D0JJ21
uniprot id: F1RZT2
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9823:JUN
gene id: 9823:JUN
uniprot id: P56432
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-271 by EP300.
messages: Belongs to the bZIP family. Jun subfamily.
messages: Heterodimer with either BATF3 or ATF7. Heterodimer with FOS (By similarity). Heterodimer with FOSB (By similarity). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Interacts with FOS and FOSB (By similarity). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA. Interacts with HIVEP3 and MYBBP1A. Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Component of an AP-1 transcription factor complex (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Interacts with methylated RNF187. Binds to HIPK3. Interacts (when phosphorylated) with FBXW7. Found in a complex with PRR7 and FBXW7. Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity. Interacts with RBM39 (By similarity). Interacts with PAGE4 (By similarity).
messages: Nucleus
messages: Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity (By similarity).
messages: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity). Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter (By similarity). Interacts with FOSB to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 site of FASLG/CD95L, and activating its transcription in T cells upon stimulation by TCR/CD3 (By similarity).
messages: Ubiquitinated by the SCF(FBXW7), leading to its degradation. Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7.

9823:APIP
gene id: 9823:APIP
uniprot id: A0A4X1SQ75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9823:TCTEX1D1
gene id: 9823:TCTEX1D1
uniprot id: A0A287B5U2
uniprot id: A0A4X1TZG5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9823:KRT74
gene id: 9823:KRT74
uniprot id: A0A4X1W662
names: Similarity
messages: Belongs to the intermediate filament family.

9823:SLC37A4
gene id: 9823:SLC37A4
uniprot id: A0A287BS88
uniprot id: A0A8D1J0W5
uniprot id: A0A8D1J3V9
uniprot id: A0A8D1KII9
uniprot id: E5DCU9
uniprot id: K9IVK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9823:SMAD3
gene id: 9823:SMAD3
uniprot id: P84024
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation in the nucleus by EP300 in the MH2 domain regulates positively its transcriptional activity and is enhanced by TGF-beta.
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Highly expressed in the brain and ovary. Detected in the pyramidal cells of the hippocampus, granule cells of the dentate gyrus, granular cells of the cerebral cortex and the granulosa cells of the ovary.
messages: Monomer; in the absence of TGF-beta (By similarity). Homooligomer; in the presence of TGF-beta (By similarity). Heterotrimer; forms a heterotrimer in the presence of TGF-beta consisting of two molecules of C-terminally phosphorylated SMAD2 or SMAD3 and one of SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex (By similarity). Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). Forms a complex with SMAD2 and TRIM33 upon addition of TGF-beta (By similarity). Found in a complex composed of SMAD3, RAN and XPO4; within the complex interacts directly with XPO4 (By similarity). Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta (By similarity). Part of a ternary complex composed of SMAD3, ITCH/AIP4 and NEDD9/HEF1; within the complex NEDD9/HEF1 interacts (via N-terminus) with ITCH/AIP4; the complex mediates ubiquitination and proteosomal degradation of NEDD9/HEF1 (By similarity). Interacts with NEDD9; the interaction promotes NEDD9 ubiquitination and proteasomal degradation (By similarity). Interacts (via an N-terminal domain) with JUN (via its basic DNA binding and leucine zipper domains); this interaction is essential for DNA binding and cooperative transcriptional activity in response to TGF-beta (By similarity). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (By similarity). Interacts with PPM1A; the interaction dephosphorylates SMAD3 in the C-terminal SXS motif leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of TGF-beta signaling (By similarity). Interacts (via MH2 domain) with ZMIZ1 (via SP-RING-type domain); in the TGF-beta signaling pathway increases the activity of the SMAD3/SMAD4 transcriptional complex (By similarity). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediating ubi…
messages: Nucleus
messages: Phosphorylated on serine and threonine residues. Enhanced phosphorylation in the linker region on Thr-179, Ser-204 and Ser-208 on EGF and TGF-beta treatment. Ser-208 is the main site of MAPK-mediated phosphorylation. CDK-mediated phosphorylation occurs in a cell-cycle dependent manner and inhibits both the transcriptional activity and antiproliferative functions of SMAD3. This phosphorylation is inhibited by flavopiridol. Maximum phosphorylation at the G(1)/S junction. Also phosphorylated on serine residues in the C-terminal SXS motif by TGFBR1 and ACVR1. TGFBR1-mediated phosphorylation at these C-terminal sites is required for interaction with SMAD4, nuclear location and transactivational activity, and appears to be a prerequisite for the TGF-beta mediated phosphorylation in the linker region. Dephosphorylated in the C-terminal SXS motif by PPM1A. This dephosphorylation disrupts the interaction with SMAD4, promotes nuclear export and terminates TGF-beta-mediated signaling. Phosphorylation at Ser-418 by CSNK1G2/CK1 promotes ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Phosphorylated by PDPK1 (By similarity).
messages: Poly-ADP-ribosylated by PARP1 and PARP2. ADP-ribosylation negatively regulates SMAD3 transcriptional responses during the course of TGF-beta signaling.
messages: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
messages: The MH1 domain is required for DNA binding (By similarity). Also binds zinc ions which are necessary for the DNA binding.
messages: The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import (By similarity).
messages: The linker region is required for the TGFbeta-mediated transcriptional activity and acts synergistically with the MH2 domain.
messages: Ubiquitinated. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Ubiquitinated by RNF111, leading to its degradation: only SMAD3 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD3 and regulating its turnover. Undergoes STUB1-mediated ubiquitination and degradation.

9823:CREG2
gene id: 9823:CREG2
uniprot id: A0A4X1W203
uniprot id: F1STG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9823:LOC100524156
gene id: 9823:LOC100524156
uniprot id: A0A287ARA8
uniprot id: A0A4X1TJ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GON7
gene id: 9823:GON7
uniprot id: P0C8B5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 plays a supporting role to the catalytic subunit OSGEP in the complex.
messages: Nucleus

9823:GTF2F2
gene id: 9823:GTF2F2
uniprot id: A0A286ZZT7
uniprot id: A0A4X1SER4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9823:TXN
gene id: 9823:TXN
uniprot id: H6TBN0
uniprot id: P82460
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the thioredoxin family.
messages: Cytoplasm
messages: Erythrocytes.
messages: Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (By similarity).
messages: In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity).
messages: Nucleus
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
messages: Secreted

9823:GP91-PHOX
gene id: 9823:GP91-PHOX
uniprot id: P52649
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1. Interacts with calprotectin (S100A8/9). Interacts with NRROS; the interaction is direct and impairs formation of a stable NADPH oxidase complex. Interacts with CYBC1; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer (By similarity). Interacts with NCF2; the interaction is enhanced in the presence of GBP7 (By similarity). The CYBA-CYBB complex interacts with GBP7 (By similarity).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes.
messages: Phosphorylated on Ser and Thr residues.
messages: Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation.

9823:AP3B1
gene id: 9823:AP3B1
uniprot id: A5A767
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9823:CTNNA1
gene id: 9823:CTNNA1
uniprot id: A0A5G2R7Z4
uniprot id: A0A8D1G1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: cytoskeleton

9823:DLGAP2
gene id: 9823:DLGAP2
uniprot id: A0A5G2QVL3
uniprot id: A0A8D1NJ08
names: Similarity
messages: Belongs to the SAPAP family.

9823:CDC25B
gene id: 9823:CDC25B
uniprot id: A0A287B203
uniprot id: A0A8D1NVI3
uniprot id: A0A8D1R4F1
uniprot id: D2KX74
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9823:KEF22 p06
gene id: 9823:KEF22_p06
uniprot id: O79880
uniprot id: Q69G28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9823:TMEM55B
gene id: 9823:TMEM55B
uniprot id: A0A286ZUJ8
uniprot id: A0A8D0T2V7
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9823:PDZK1IP1
gene id: 9823:PDZK1IP1
uniprot id: Q6ITQ4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PDZK1. Forms a heterodimer with SLC5A2; this interaction enhances SLC5A2 transporter activity over a hundred-fold.
messages: Membrane

9823:AZIN1
gene id: 9823:AZIN1
uniprot id: A0A4X1TPS5
uniprot id: B2ZDY9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9823:GATC
gene id: 9823:GATC
uniprot id: A0A4X1T4U0
uniprot id: A0A5G2R2H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9823:PTPRK
gene id: 9823:PTPRK
uniprot id: A0A287AEP8
uniprot id: A0A287B937
uniprot id: A0A480JYK3
uniprot id: A0A480NFN1
uniprot id: A0A8D0XAV0
uniprot id: A0A8D1PZ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9823:ELOVL3
gene id: 9823:ELOVL3
uniprot id: A0A4X1TWB9
uniprot id: D0G6S7
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9823:SLC18B1
gene id: 9823:SLC18B1
uniprot id: A0A8D0UG90
uniprot id: F1S3R0
names: Subcellular Location Annotation
messages: Membrane

9823:H2AFY
gene id: 9823:H2AFY
uniprot id: A0A480IQL7
uniprot id: A0A480LAT2
uniprot id: A0A4X1UYU9
uniprot id: A0A8D0PJV4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9823:PRICKLE2
gene id: 9823:PRICKLE2
uniprot id: A0A287AHV3
uniprot id: A0A8D1TDN5
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9823:TIMM21
gene id: 9823:TIMM21
uniprot id: A0A287BDA0
uniprot id: A0A4X1U114
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9823:CHD2
gene id: 9823:CHD2
uniprot id: A0A287A4M4
uniprot id: A0A480J265
uniprot id: A0A8D0MD56
uniprot id: A0A8D1GYR2
names: Subcellular Location Annotation
messages: Nucleus

9823:NPM3
gene id: 9823:NPM3
uniprot id: A0A4X1TVC5
uniprot id: F1S8T7
names: Similarity
messages: Belongs to the nucleoplasmin family.

9823:TCTEX1D4
gene id: 9823:TCTEX1D4
uniprot id: Q4VYA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein light chain Tctex-type family.
messages: Cytoplasm
messages: Interacts with ENG/endoglin, TGFBR2 and TGFBR3. Interacts with PPP1CC.
messages: Nucleus
messages: acrosome
messages: cilium axoneme
messages: flagellum
messages: microtubule organizing center

9823:PFKFB4
gene id: 9823:PFKFB4
uniprot id: A0A287BL63
uniprot id: A0A480JXS5
uniprot id: A0A4X1T351
uniprot id: A0A8D1BFL5
uniprot id: A0A8D1YHI4
uniprot id: F1SKM3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9823:RPE
gene id: 9823:RPE
uniprot id: A0A286ZQY9
uniprot id: A0A4X1UW99
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9823:AMDHD2
gene id: 9823:AMDHD2
uniprot id: A0A480ZRW5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.
messages: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.

9823:LDAH
gene id: 9823:LDAH
uniprot id: A0A4X1TWU3
uniprot id: I3L9Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

9823:LOC692190
gene id: 9823:LOC692190
uniprot id: Q2VBJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:CLDN8
gene id: 9823:CLDN8
uniprot id: C3VMK5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:DPCD
gene id: 9823:DPCD
uniprot id: A0A287ACI5
uniprot id: A0A4X1U0N3
uniprot id: F1S8U0
names: Similarity
messages: Belongs to the DPCD family.

9823:TMBIM4
gene id: 9823:TMBIM4
uniprot id: A0A480YW12
uniprot id: A0A4X1W3Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9823:CPPED1
gene id: 9823:CPPED1
uniprot id: A0A5G2QI52
uniprot id: A0A8D1QU30
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9823:CERS3
gene id: 9823:CERS3
uniprot id: A0A4X1UI88
uniprot id: F1SR96
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9823:CRYBB2
gene id: 9823:CRYBB2
uniprot id: A0A4X1SKX0
uniprot id: F1RG87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9823:UNC119B
gene id: 9823:UNC119B
uniprot id: A0A4X1T6U9
uniprot id: F1RJH3
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9823:LOC100524855
gene id: 9823:LOC100524855
uniprot id: A0A5G2RGH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FABP6
gene id: 9823:FABP6
uniprot id: A0A8D0TPC0
uniprot id: P10289
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.
messages: Found exclusively in the ileum and to a lesser extent in distal jejunum.
messages: Membrane

9823:SYS1
gene id: 9823:SYS1
uniprot id: A0A8D0PP51
uniprot id: F1SD37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9823:BPIFC
gene id: 9823:BPIFC
uniprot id: A0A4X1SXV5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9823:MRPL47
gene id: 9823:MRPL47
uniprot id: A0A4X1V3N8
uniprot id: F1SGC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

9823:IRAK4
gene id: 9823:IRAK4
uniprot id: A0A8D1BGX3
uniprot id: A9QT42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9823:CAMK2G
gene id: 9823:CAMK2G
uniprot id: A0A8D1MEG3
uniprot id: A0A8D1RV00
uniprot id: A0A8D1RVW6
uniprot id: A0A8D1TEB7
uniprot id: Q7JFN2
uniprot id: Q7JFN3
uniprot id: Q7JFN4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9823:RFLNA
gene id: 9823:RFLNA
uniprot id: A0A4X1UJ62
uniprot id: A0A5G2QSA2
uniprot id: A0A8D1UKA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9823:HBM
gene id: 9823:HBM
uniprot id: A0A4X1UM07
uniprot id: F1RGX5
names: Similarity
messages: Belongs to the globin family.

9823:TTC39C
gene id: 9823:TTC39C
uniprot id: A0A4X1VND1
uniprot id: F1SBB2
names: Similarity
messages: Belongs to the TTC39 family.

9823:FNBP1L
gene id: 9823:FNBP1L
uniprot id: A0A4X1TWN7
uniprot id: A0A4X1U250
uniprot id: A0A8D1KTH2
uniprot id: F1S535
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9823:PIGC
gene id: 9823:PIGC
uniprot id: A0A8D0SHR8
uniprot id: D0G788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9823:GLE1
gene id: 9823:GLE1
uniprot id: A0A4X1TXP4
uniprot id: F1RR80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

9823:RXFP4
gene id: 9823:RXFP4
uniprot id: A0A4X1VU72
uniprot id: Q5Y982
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:APMAP
gene id: 9823:APMAP
uniprot id: A0A8D2BP17
names: Similarity
messages: Belongs to the strictosidine synthase family.

9823:COG1
gene id: 9823:COG1
uniprot id: A0A286ZIG9
uniprot id: A0A8D0UXS2
uniprot id: A0A8D0X3J6
uniprot id: F1RV32
names: Similarity
messages: Belongs to the COG1 family.

9823:SOST
gene id: 9823:SOST
uniprot id: A0A287APD7
uniprot id: A0A4X1TT30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the sclerostin family.
messages: Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
messages: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

9823:GLUL
gene id: 9823:GLUL
uniprot id: P46410
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Decamer; composed of two pentamers (By similarity). Interacts with PALMD (By similarity). Interacts with RHOJ (By similarity).
messages: Glutamine synthetase activity is inhibited by methionine sulfoximine (MSO).
messages: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity).
messages: Microsome
messages: Mitochondrion
messages: Palmitoylated; undergoes autopalmitoylation.
messages: Ubiquitinated by ZNRF1.
messages: cytosol

9823:USP15
gene id: 9823:USP15
uniprot id: A0A4X1W4U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9823:PUSL1
gene id: 9823:PUSL1
uniprot id: A0A5G2QB89
uniprot id: A0A8D0VSL6
uniprot id: A0A8D1UHR8
uniprot id: F1RJE9
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9823:FMNL1
gene id: 9823:FMNL1
uniprot id: A0A480LCB3
uniprot id: A0A480T1G5
uniprot id: A0A8D0XC04
uniprot id: A0A8D1CCX1
names: Similarity
messages: Belongs to the formin homology family.

9823:LOC100517891
gene id: 9823:LOC100517891
uniprot id: A0A4X1VQR2
uniprot id: F1RJ50
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9823:IFN-ALPHA-16
gene id: 9823:IFN-ALPHA-16
uniprot id: C8CKA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:POU1F1
gene id: 9823:POU1F1
uniprot id: A0A4X1UP07
uniprot id: A0A8D0Q633
uniprot id: D9ZNP5
uniprot id: F6Q7Q0
uniprot id: Q04788
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Interacts with PITX1. Interacts with LHX3. Interacts with ELK1.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

9823:RPS23
gene id: 9823:RPS23
uniprot id: Q6SA96
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with the African swine fever virus (ASFV) ubiquitin-conjugating enzyme UBCv1; this interaction probably plays a role in the viral regulation of host protein synthesis.
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24930395). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy (By similarity).
messages: Cytoplasm
messages: Hydroxylation at Pro-62 affects translation termination efficiency.
messages: Rough endoplasmic reticulum
messages: cytosol

9823:PPIA
gene id: 9823:PPIA
uniprot id: A0A5G2QWG7
uniprot id: A0A8D1MG75
uniprot id: F2Q9A3
uniprot id: P62936
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).
messages: Cytoplasm
messages: Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: Secreted

9823:IER2
gene id: 9823:IER2
uniprot id: A0A4X1T0S1
names: Similarity
messages: Belongs to the IER family.

9823:PPP1R11
gene id: 9823:PPP1R11
uniprot id: A0A4X1VLG5
uniprot id: B6ICU5
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9823:AKAP3
gene id: 9823:AKAP3
uniprot id: A0A8D1RRN7
uniprot id: D3K5M3
names: Similarity
messages: Belongs to the AKAP110 family.

9823:RXRB
gene id: 9823:RXRB
uniprot id: A0A4X1UQM7
uniprot id: A0A8D0VA87
uniprot id: A5D9P3
uniprot id: F6PWE0
uniprot id: Q0GFF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9823:PAQR4
gene id: 9823:PAQR4
uniprot id: A0A4X1VVI1
uniprot id: I3LP82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:CNIH2
gene id: 9823:CNIH2
uniprot id: A0A4X1TQN2
uniprot id: A0A4X1TVN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9823:LHX8
gene id: 9823:LHX8
uniprot id: A0A287AS47
uniprot id: A0A4X1UFM4
uniprot id: A0A4X1UFN3
uniprot id: C8YLT4
names: Subcellular Location Annotation
messages: Nucleus

9823:XCL1
gene id: 9823:XCL1
uniprot id: B3VFB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Belongs to the intercrine gamma family.
messages: Secreted

9823:TRIM54
gene id: 9823:TRIM54
uniprot id: G0WLG4
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9823:LOC100621778
gene id: 9823:LOC100621778
uniprot id: A0A4X1UFT4
uniprot id: A0A8D0SZK8
uniprot id: I3LFR7
names: Subcellular Location Annotation
messages: Membrane

9823:SAL1
gene id: 9823:SAL1
uniprot id: P81608
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Binds pheromones, the pheromones are released from the saliva of males and affect the sexual behavior of females.
messages: Homodimer.
messages: In the submaxillary salivary glands of mature male pigs, but absent from that of females. Expression was much lower in submaxillary glands of castrated male pigs than in sexually mature individuals.
messages: Secreted
messages: Two isoforms have been identified which differ by 3 residues.

9823:SLC2A12
gene id: 9823:SLC2A12
uniprot id: A0A287BJ50
uniprot id: A0A480R5U9
uniprot id: A0A4X1VBK9
uniprot id: A0A8D1L1W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane

9823:MRPS16
gene id: 9823:MRPS16
uniprot id: A0A480JTD7
uniprot id: A0A8D1RWM4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9823:SPI1
gene id: 9823:SPI1
uniprot id: A0A8D1CP84
uniprot id: Q6PKU1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETS family.
messages: Binds DNA as a monomer. Can form homomers (By similarity). Directly interacts with CEBPD/NF-IL6-beta; this interaction does not affect DNA-binding properties of each partner. Interacts with NONO/p54(nrb) (By similarity). Interacts with RUNX1/AML1. Interacts with GFI1; the interaction represses SPI1 transcriptional activity, hence blocks SPI1-induced macrophage differentiation of myeloid progenitor cells. Interacts with CEBPE. Interacts with IRF4/Pip and IRF8. Interacts with JUN. Interacts with RB1. Interacts with TBP (By similarity).
messages: Nucleus
messages: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition. Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (By similarity). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity).
messages: Transcriptional activity at macrophage-specific genes is inhibited by interaction with GFI1, which results in the inhibition of SPI1-induced macrophage differentiation of myeloid progenitor cells, but not that of the granulocyte lineage.

9823:IL4
gene id: 9823:IL4
uniprot id: F1CFE1
uniprot id: Q04745
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
messages: Secreted

9823:SLC44A4
gene id: 9823:SLC44A4
uniprot id: A5PF08
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CTL (choline transporter-like) family.
messages: Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (By similarity).
messages: Membrane
messages: N-glycosylated; N-glycosylation of Asn-677 and Asn-390 is required for a proper thiamine pyrophosphate uptake.

9823:TMEM234
gene id: 9823:TMEM234
uniprot id: A0A481BBG1
uniprot id: A0A4X1VZD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

9823:CITED2
gene id: 9823:CITED2
uniprot id: A0A287A4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9823:XPO7
gene id: 9823:XPO7
uniprot id: A0A4X1VH76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9823:VIP
gene id: 9823:VIP
uniprot id: A0A4X1VRK9
uniprot id: E0Y441
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

9823:TMEM17
gene id: 9823:TMEM17
uniprot id: A0A4X1WBK8
uniprot id: I3LBE3
names: Subcellular Location Annotation
messages: Membrane

9823:KCNK1
gene id: 9823:KCNK1
uniprot id: A0A4X1UHG4
uniprot id: F1RGV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9823:DHX8
gene id: 9823:DHX8
uniprot id: A0A480JVQ7
uniprot id: A0A4X1TNW0
names: Subcellular Location Annotation
messages: Nucleus

9823:C4A
gene id: 9823:C4A
uniprot id: B0LFE9
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse
messages: axon
messages: dendrite

9823:WDR82
gene id: 9823:WDR82
uniprot id: A0A4X1VQG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9823:HOXA13
gene id: 9823:HOXA13
uniprot id: D3K5K0
names: Subcellular Location Annotation
messages: Nucleus

9823:FLVCR2
gene id: 9823:FLVCR2
uniprot id: B7TJ17
names: Subcellular Location Annotation
messages: Membrane

9823:DNAJC2
gene id: 9823:DNAJC2
uniprot id: A0A4X1VB48
uniprot id: A0A5G2QWE3
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: cytosol

9823:TSHR
gene id: 9823:TSHR
uniprot id: A0A4X1T1H2
uniprot id: Q8SPP9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Expressed in thyroide cells (at protein level).
messages: Glycosylated.
messages: Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production. Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
messages: Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation.

9823:CTH
gene id: 9823:CTH
uniprot id: Q19QT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate. Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity).
messages: Cytoplasm
messages: Homotetramer (By similarity). Interacts with CALM in a calcium-dependent manner (By similarity).

9823:HGD
gene id: 9823:HGD
uniprot id: A0A8D0RFQ6
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9823:PYY
gene id: 9823:PYY
uniprot id: A0A4X1TPM5
uniprot id: F1RQY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9823:UBE2L6
gene id: 9823:UBE2L6
uniprot id: A0A8D0VBE8
uniprot id: F4ZS20
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:HYAL1
gene id: 9823:HYAL1
uniprot id: Q6RHW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Highly expressed in spleen, kidney, and lung.
messages: Lysosome
messages: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity).
messages: Secreted

9823:GNA14
gene id: 9823:GNA14
uniprot id: A0A4X1VWA1
uniprot id: A4L2Z4
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9823:LOC100154071
gene id: 9823:LOC100154071
uniprot id: A0A8D1EP48
uniprot id: F1RPL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:LPGAT1
gene id: 9823:LPGAT1
uniprot id: A0A4X1TLD3
uniprot id: F1S2U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9823:HOXB1
gene id: 9823:HOXB1
uniprot id: A0A4X1UPQ8
uniprot id: F1RWG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9823:UNC119
gene id: 9823:UNC119
uniprot id: A0A4X1TSA4
uniprot id: F1RND0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDE6D/unc-119 family.
messages: spindle

9823:ACKR1
gene id: 9823:ACKR1
uniprot id: A0A8D1GND3
uniprot id: Q70DY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome

9823:SNX21
gene id: 9823:SNX21
uniprot id: A0A8D1D249
uniprot id: F1SC77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9823:LOC100156967
gene id: 9823:LOC100156967
uniprot id: A0A4X1TPC0
uniprot id: F1SJ34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9823:CLRN3
gene id: 9823:CLRN3
uniprot id: A0A481BEG6
uniprot id: A0A4X1VAS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9823:POLD1
gene id: 9823:POLD1
uniprot id: A0A480Y1A1
uniprot id: A0A8D1A5L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9823:PEA15
gene id: 9823:PEA15
uniprot id: A0A287AGA5
uniprot id: A0A4X1VP31
names: Subcellular Location Annotation
messages: Cytoplasm

9823:CLIC2
gene id: 9823:CLIC2
uniprot id: A0A287A7Q5
uniprot id: A0A4X1T8K6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9823:CNGA4
gene id: 9823:CNGA4
uniprot id: A0A8D1UWC4
uniprot id: F1RMM3
names: Subcellular Location Annotation
messages: Membrane

9823:UROS
gene id: 9823:UROS
uniprot id: A0A287AZN2
uniprot id: A0A481ACB7
uniprot id: A0A4X1VCE1
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9823:KRT10
gene id: 9823:KRT10
uniprot id: I3LDS3
names: Similarity
messages: Belongs to the intermediate filament family.

9823:SLC15A1
gene id: 9823:SLC15A1
uniprot id: A0A8D2AB23
uniprot id: Q7YSA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9823:CREB5
gene id: 9823:CREB5
uniprot id: A0A4X1TIZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9823:FAM49A
gene id: 9823:FAM49A
uniprot id: A0A4X1U5L7
uniprot id: F2Z5E7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9823:CACNG4
gene id: 9823:CACNG4
uniprot id: A0A4X1SUR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

9823:LOC102167841
gene id: 9823:LOC102167841
uniprot id: A0A4X1V306
uniprot id: F1SCA1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SPOP
gene id: 9823:SPOP
uniprot id: A0A4X1URQ9
uniprot id: I3LA15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9823:KLHL15
gene id: 9823:KLHL15
uniprot id: A0A287BB55
uniprot id: A0A8D1HS75
names: Subcellular Location Annotation
messages: Nucleus

9823:CYP17A1
gene id: 9823:CYP17A1
uniprot id: P19100
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity.

9823:LOC574051
gene id: 9823:LOC574051
uniprot id: A0A8D0LUN8
uniprot id: Q4TTS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9823:PDE3A
gene id: 9823:PDE3A
uniprot id: Q9XSW7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9823:AP4E1
gene id: 9823:AP4E1
uniprot id: A0A5G2Q7U6
uniprot id: A0A8D1QJQ9
names: Function
names: Similarity
names: Subunit
messages: Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

9823:SERPINB1
gene id: 9823:SERPINB1
uniprot id: A0A4X1SRT1
uniprot id: M3TYG7
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9823:CTSW
gene id: 9823:CTSW
uniprot id: A0A4X1UGM7
uniprot id: F1RU23
names: Similarity
messages: Belongs to the peptidase C1 family.

9823:XPNPEP1
gene id: 9823:XPNPEP1
uniprot id: A0A480Q815
uniprot id: A0A480Y1M9
uniprot id: A0A4X1THI9
uniprot id: A0A8D0YGN2
uniprot id: K9IVF7
names: Similarity
messages: Belongs to the peptidase M24B family.

9823:NPY5R
gene id: 9823:NPY5R
uniprot id: O97969
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity).

9823:TMEM192
gene id: 9823:TMEM192
uniprot id: A0A8D0MB47
uniprot id: A0A8D0USG2
uniprot id: I3LGY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9823:B4GALT6
gene id: 9823:B4GALT6
uniprot id: A0A4X1VLT3
uniprot id: A0A5G2QU42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9823:CDC6
gene id: 9823:CDC6
uniprot id: A0A8D0RTM8
uniprot id: F1RXE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9823:PTN
gene id: 9823:PTN
uniprot id: A0A480VM92
uniprot id: A0A8D0UHY1
uniprot id: P79281
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pleiotrophin family.
messages: Interacts with ALK and NEK6. Interacts with PTPRZ1 (via chondroitin sulfate groups); promotes formation of homooligomers; oligomerization impairs tyrosine phosphatase activity. Forms a complex with PTPRZ1 and CTNNB1; this complex inactivates PTPRZ1 protein tyrosine phosphatase activity through PTN interaction and stimulates tyrosine phosphorylation of CTNNB1. Interacts with ITGB3 and ITGA5. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through ITGB3 'Tyr-773' phosphorylation (By similarity). Interacts with SDC3 (via heparan sulfate chains); this interaction mediates the neurite outgrowth-promoting signal from PTN to the cytoskeleton of growing neurites; this interaction mediates osteoblast recruitment. Interacts with GPC2 (via heparan sulfate); this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2 (By similarity).
messages: Phosphorylated by NEK6.
messages: Secreted
messages: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway. Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion. Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-…

9823:SNRPA1
gene id: 9823:SNRPA1
uniprot id: A0A480UFC4
uniprot id: A0A4X1U918
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9823:ACSM4
gene id: 9823:ACSM4
uniprot id: A0A8D1CNJ0
uniprot id: I3LSY0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:BACE2
gene id: 9823:BACE2
uniprot id: A0A4X1TLE9
uniprot id: A0A5G2R620
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane

9823:CEBPA
gene id: 9823:CEBPA
uniprot id: A0A4X1TNP2
uniprot id: F1RNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9823:AIP
gene id: 9823:AIP
uniprot id: A0A4X1T3G1
uniprot id: F1RUZ6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
messages: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

9823:EIF3H
gene id: 9823:EIF3H
uniprot id: A0A480JK41
uniprot id: A0A4X1T8R1
uniprot id: A0A4X1T8R5
uniprot id: F1S1J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9823:ARL6IP4
gene id: 9823:ARL6IP4
uniprot id: A0A287AL31
uniprot id: A0A4X1UG70
uniprot id: A0A4X1UHF9
uniprot id: F1RFJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: Nucleus speckle
messages: nucleolus

9823:BIRC5
gene id: 9823:BIRC5
uniprot id: Q9GLN5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.
messages: Belongs to the IAP family.
messages: Chromosome
messages: Cytoplasm
messages: In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity. Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis.
messages: Midbody
messages: Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8. Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce. Interacts with FBXL7; this interaction facilitates the polyubiquitination and subsequent proteasomal degradation of BIRC5 by the SCF(FBXL7) E3 ubiquitin-protein ligase complex (By similarity).
messages: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity).
messages: Nucleus
messages: The BIR repeat is necessary and sufficient for LAMTOR5 binding.
messages: Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.
messages: centromere
messages: kinetochore
messages: spindle

9823:SLC22A7
gene id: 9823:SLC22A7
uniprot id: Q1RPP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Mediates sodium-independent multispecific organic anion transport.

9823:MSH5
gene id: 9823:MSH5
uniprot id: B9TSR3
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9823:SLC9A3R2
gene id: 9823:SLC9A3R2
uniprot id: A0A8D0R8F9
uniprot id: B6EAV5
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

9823:GPAT3
gene id: 9823:GPAT3
uniprot id: A0A287BKR7
uniprot id: A0A4X1TMU6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:GABRP
gene id: 9823:GABRP
uniprot id: A0A4X1U980
uniprot id: F1RRX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:GMPR2
gene id: 9823:GMPR2
uniprot id: A0A480Y306
uniprot id: A0A4X1SPZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9823:GNB2
gene id: 9823:GNB2
uniprot id: A0A4X1UES8
uniprot id: F2Z4Z8
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9823:SMPD2
gene id: 9823:SMPD2
uniprot id: A0A8D0MKL3
uniprot id: F1RSY4
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9823:LOC110255211
gene id: 9823:LOC110255211
uniprot id: A0A287BDV7
uniprot id: A0A4X1ST70
uniprot id: A0A4X1TVA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9823:MSI1
gene id: 9823:MSI1
uniprot id: I7GVS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm

9823:CCBE1
gene id: 9823:CCBE1
uniprot id: A0A5G2R6U5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:HPS6
gene id: 9823:HPS6
uniprot id: A0A8D0TMT0
uniprot id: A5A775
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9823:NDST2
gene id: 9823:NDST2
uniprot id: A0A287BFJ7
uniprot id: A0A4X1SY66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9823:SOSTDC1
gene id: 9823:SOSTDC1
uniprot id: A0A4X1TIA5
uniprot id: F1SEJ1
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CYP2R1
gene id: 9823:CYP2R1
uniprot id: A0A0H4ITY4
uniprot id: A0A4X1TKK9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:RITA1
gene id: 9823:RITA1
uniprot id: A0A8D0MBD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RITA family.
messages: Cytoplasm
messages: Interacts with RBPJ/RBPSUH.
messages: Nucleus
messages: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

9823:NDUFS2
gene id: 9823:NDUFS2
uniprot id: A0A480JYS1
uniprot id: A0A4X1VKC6
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

9823:ACP1
gene id: 9823:ACP1
uniprot id: A0A4X1UMF6
uniprot id: P81693
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm
messages: Inhibited by sulfhydryl reagents.
messages: Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1. Interacts with the SH3 domain of SPTAN1.
messages: Phosphorylated by LCK. Phosphorylation at Tyr-132 increases its phosphatase activity.

9823:PLP1
gene id: 9823:PLP1
uniprot id: Q712P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: Myelin membrane
messages: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin (By similarity).

9823:PDF
gene id: 9823:PDF
uniprot id: A0A480VWD0
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

9823:ARHGDIA
gene id: 9823:ARHGDIA
uniprot id: A0A4X1UB74
uniprot id: E7EI20
names: Similarity
messages: Belongs to the Rho GDI family.

9823:LOC100524391
gene id: 9823:LOC100524391
uniprot id: A0A4X1U9Q6
uniprot id: A0A4X1UAI4
uniprot id: F1RWA0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:PGF
gene id: 9823:PGF
uniprot id: A0A4X1TBZ8
uniprot id: A0A4X1TCD5
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9823:STARD5
gene id: 9823:STARD5
uniprot id: A0A4X1US69
uniprot id: F1RID6
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9823:RPS27A
gene id: 9823:RPS27A
uniprot id: A0A4X1WDC9
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9823:SLC39A9
gene id: 9823:SLC39A9
uniprot id: A0A4X1U4B0
uniprot id: A0A5K1UQV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

9823:LBX2
gene id: 9823:LBX2
uniprot id: A0A4X1W775
uniprot id: F1SNT2
names: Subcellular Location Annotation
messages: Nucleus

9823:TLR10
gene id: 9823:TLR10
uniprot id: Q4LDR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9823:S100G
gene id: 9823:S100G
uniprot id: P02632
names: Similarity
messages: Belongs to the S-100 family.

9823:LGALS4
gene id: 9823:LGALS4
uniprot id: Q29058
names: Domain
names: Function
names: Subunit
messages: Contains two homologous but distinct carbohydrate-binding domains.
messages: Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
messages: Monomer.

9823:EBF3
gene id: 9823:EBF3
uniprot id: A0A8D1DHG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9823:SESN3
gene id: 9823:SESN3
uniprot id: A0A287A0W1
uniprot id: A0A4X1TWE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9823:AP1M1
gene id: 9823:AP1M1
uniprot id: A0A4X1UZG6
uniprot id: A0A4X1V0U3
uniprot id: F2Z5I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9823:HOXD9
gene id: 9823:HOXD9
uniprot id: A0A8D1TV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9823:PSMA4
gene id: 9823:PSMA4
uniprot id: A0A4X1UWZ5
uniprot id: A0A5G2R1I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9823:BGLAP
gene id: 9823:BGLAP
uniprot id: A0A4X1VY69
uniprot id: F6PUF1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9823:AQP8
gene id: 9823:AQP8
uniprot id: A8WCF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:STIM1
gene id: 9823:STIM1
uniprot id: A0A287AX96
uniprot id: A0A8D0W1L6
uniprot id: B4XH83
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:INHBA
gene id: 9823:INHBA
uniprot id: P03970
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9823:EIF4G1
gene id: 9823:EIF4G1
uniprot id: A0A480IQ15
uniprot id: A0A480VXI3
uniprot id: A0A4X1UP28
uniprot id: A0A4X1URB6
uniprot id: A0A8D0QG87
uniprot id: A0A8D0S1T9
uniprot id: A0A8D0WUP9
uniprot id: F8TEL5
uniprot id: I3LMH4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9823:ANTXRL
gene id: 9823:ANTXRL
uniprot id: A0A4X1VH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9823:NDST3
gene id: 9823:NDST3
uniprot id: F1S152
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9823:PSP-II
gene id: 9823:PSP-II
uniprot id: P35496
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the spermadhesin family.
messages: Monomer or heterodimer with PSP-I (depending on the type of glycosylation of PSP-I).
messages: Secreted
messages: Seminal plasma or sperm.

9823:SIN3A
gene id: 9823:SIN3A
uniprot id: A0A4X1TUT9
uniprot id: F1SJ69
names: Subcellular Location Annotation
messages: Nucleus

9823:RRS1
gene id: 9823:RRS1
uniprot id: A0A8D1H3D5
uniprot id: F1RTZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9823:SELE
gene id: 9823:SELE
uniprot id: P98110
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Cell-surface glycoprotein having a role in immunoadhesion (PubMed:7526854). Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis (By similarity).
messages: Important in acute cellular allograft rejection and probably also in xenograft rejection.
messages: Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction.

9823:LDHC
gene id: 9823:LDHC
uniprot id: Q9TSX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2.
messages: Possible role in sperm motility.

9823:KCTD20
gene id: 9823:KCTD20
uniprot id: A0A287BSI8
uniprot id: A0A481D8Q7
uniprot id: A0A4X1STM3
names: Subcellular Location Annotation
messages: Cytoplasm

9823:OPRK1
gene id: 9823:OPRK1
uniprot id: A0A4X1T6Q9
uniprot id: F1RSG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with SLC9A3R1. Interacts with GABARAPL1.
messages: Membrane

9823:SLC12A5
gene id: 9823:SLC12A5
uniprot id: A0A287BS17
uniprot id: A0A4X1U3U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9823:LOC100514307
gene id: 9823:LOC100514307
uniprot id: A0A8D0SUE5
uniprot id: I3LMD2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FKBP5
gene id: 9823:FKBP5
uniprot id: A0A023PN04
uniprot id: A0A8D0K0N9
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100513978
gene id: 9823:LOC100513978
uniprot id: A0A4X1VQY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FZD3
gene id: 9823:FZD3
uniprot id: A0A286ZRQ0
uniprot id: A0A4X1VBQ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:OSGEPL1
gene id: 9823:OSGEPL1
uniprot id: F1RXU6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9823:CHRM1
gene id: 9823:CHRM1
uniprot id: P04761
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
messages: Cell membrane
messages: Interacts with GPRASP2 (By similarity). Interacts with TMEM147 (By similarity).
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9823:RPS6KB2
gene id: 9823:RPS6KB2
uniprot id: A0A8D0VH50
uniprot id: F1RUZ0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9823:GGACT
gene id: 9823:GGACT
uniprot id: A0A5G2QZR2
uniprot id: A0A8D0Y8Y3
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9823:PNCK
gene id: 9823:PNCK
uniprot id: D3K5L6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:MARVELD3
gene id: 9823:MARVELD3
uniprot id: A0A8D1LIC4
uniprot id: A0A8D1YJQ9
uniprot id: F1S3D4
names: Subcellular Location Annotation
messages: Membrane

9823:CD247
gene id: 9823:CD247
uniprot id: Q589C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9823:GHRHR
gene id: 9823:GHRHR
uniprot id: E5F1H3
uniprot id: P34999
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane
messages: Pituitary gland. Also detected in the lymphocytes and thymocytes.
messages: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

9823:HIF1A
gene id: 9823:HIF1A
uniprot id: A0T1H6
names: Subcellular Location Annotation
messages: Cytoplasm

9823:FOXO1
gene id: 9823:FOXO1
uniprot id: A4L7N3
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated. Acetylation at Lys-269 and Lys-281 are necessary for autophagic cell death induction. Deacetylated by SIRT2 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagic cell death. Once in the nucleus, acetylated by CREBBP/EP300. Acetylation diminishes the interaction with target DNA and attenuates the transcriptional activity. It increases the phosphorylation at Ser-263. Deacetylation by SIRT1 results in reactivation of the transcriptional activity. Oxidative stress by hydrogen peroxide treatment appears to promote deacetylation and uncoupling of insulin-induced phosphorylation. By contrast, resveratrol acts independently of acetylation. Acetylated at Lys-430, promoting its localization to the nucleus and transcription factor activity. Deacetylation at Lys-430 by SIRT6, promotes its translocation into the cytoplasm, preventing its transcription factor activity. Deacetylation and subsequent inhibition by SIRT6 has different effects depending on cell types: it inhibits gluconeogenesis in hepatocytes, promotes glucose sensing in pancreatic beta-cells and regulates lipid catabolism in brown adipocytes.
messages: Cytoplasm
messages: Highly in subcutaneous adipose and visceral adipose tissues. Levels higher in piglets than in adults. Also expressed at lower levels in liver and muscle.
messages: Interacts with LRPPRC. Interacts with RUNX2; the interaction inhibits RUNX2 transcriptional activity and mediates the IGF1/insulin-dependent BGLAP expression in osteoblasts Interacts with PPP2R1A; the interaction regulates the dephosphorylation of FOXO1 at Thr-24 and Ser-263 leading to its nuclear import. Interacts with NLK. Interacts with SIRT1; the interaction results in the deacetylation of FOXO1 leading to activation of FOXO1-mediated transcription of genes involved in DNA repair and stress resistance. Binds to CDK1. Interacts with the 14-3-3 proteins, YWHAG and YWHAZ; the interactions require insulin-stimulated phosphorylation on Thr-24, promote nuclear exit and loss of transcriptional activity. Interacts with SKP2; the interaction ubiquitinates FOXO1 leading to its proteosomal degradation. The interaction requires the presence of KRIT1. Interacts (via the C-terminal half) with ATF4 (via its DNA binding domain); the interaction occurs in osteoblasts, regulates glucose homeostasis via suppression of beta-cell proliferation and subsequent decrease in insulin production. Interacts with PRMT1; the interaction methylates FOXO1, prevents PKB/AKT1 phosphorylation and retains FOXO1 in the nucleus. Interacts with EP300 and CREBBP; the interactions acetylate FOXO1. Interacts with SIRT2; the interaction is disrupted in response to oxidative stress or serum deprivation, leading to increased level of acetylated FOXO1, which promotes stress-induced autophagy by stimulating E1-like activating enzyme ATG7. Interacts (acetylated form) with ATG7; the interaction is increased in response to oxidative stress or serum deprivation and promotes the autophagic process leading to cell death. Interacts (acetylated form) with PPARG. Interacts with XBP1; this interaction is direct and leads to FOXO1 ubiquitination and degradation via the proteasome pathway (By similarity). Interacts (via the Fork-head domain) with CEBPA; the interaction increases when FOXO1 is deacetylated. Interacts with…
messages: Methylation inhibits AKT1-mediated phosphorylation at Ser-263 and is increased by oxidative stress.
messages: Nucleus
messages: Phosphorylation by NLK promotes nuclear export and inhibits the transcriptional activity. In response to growth factors, phosphorylation on Thr-24, Ser-263 and Ser-326 by PKB/AKT1 promotes nuclear export and inactivation of transactivational activity. Phosphorylation on Thr-24 is required for binding 14-3-3 proteins. Phosphorylation of Ser-263 decreases DNA-binding activity and promotes the phosphorylation of Thr-24 and Ser-326, permitting phosphorylation of Ser-329 and Ser-332, probably by CDK1, leading to nuclear exclusion and loss of function. Stress signals, such as response to oxygen or nitric oxide, attenuate the PKB/AKT1-mediated phosphorylation leading to nuclear retention. Phosphorylation of Ser-336 is independent of IGF1 and leads to reduced function. Dephosphorylated on Thr-24 and Ser-263 by PP2A in beta-cells under oxidative stress leading to nuclear retention. Phosphorylation of Ser-256 by CDK1 disrupts binding of 14-3-3 proteins leading to nuclear accumulation and has no effect on DNA binding nor transcriptional activity. Phosphorylation by STK4/MST1 on Ser-219, upon oxidative stress, inhibits binding to 14-3-3 proteins and nuclear export (By similarity). PPIA/CYPA promotes its dephosphorylation on Ser-263 (By similarity).
messages: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:18293098). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (By similarity). Activity suppressed by insulin (By similarity). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (By similarity). Promotes neural cell death (By similarity). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive…
messages: Ubiquitinated by SKP2. Ubiquitination leads to proteasomal degradation (By similarity).
messages: Up-regulated during preadipocyte differentiation. Down-regulated in these cells on treatment with IGF1.

9823:FBLN7
gene id: 9823:FBLN7
uniprot id: A0A4X1VFY2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:VGLL2
gene id: 9823:VGLL2
uniprot id: A0A8D0QPP3
uniprot id: F1SF19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9823:CNOT3
gene id: 9823:CNOT3
uniprot id: A0A480S6G3
uniprot id: A0A8D1GKB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

9823:VDR
gene id: 9823:VDR
uniprot id: A3RGC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with the corepressor NCOR1. Interacts with SNW1. Interacts with IRX4, the interaction does not affect its transactivation activity (By similarity). Interacts with CRY1 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).
messages: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity).
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9823:TMEM86A
gene id: 9823:TMEM86A
uniprot id: A0A4X1T895
uniprot id: F1SFX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9823:TM2D2
gene id: 9823:TM2D2
uniprot id: A0A4X1VRA5
uniprot id: I3LTJ8
names: Subcellular Location Annotation
messages: Membrane

9823:CNFN
gene id: 9823:CNFN
uniprot id: A0A4X1SJA2
uniprot id: A0A4X1SJI1
names: Similarity
messages: Belongs to the cornifelin family.

9823:LOC100151929
gene id: 9823:LOC100151929
uniprot id: A0A4X1SRS0
uniprot id: F1S964
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PQLC1
gene id: 9823:PQLC1
uniprot id: A0A287AKV6
uniprot id: A0A4X1SCZ2
uniprot id: A0A4X1SDE9
names: Subcellular Location Annotation
messages: Membrane

9823:COQ9
gene id: 9823:COQ9
uniprot id: A0A480PNJ5
uniprot id: A0A4X1UZ68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9823:CCNJ
gene id: 9823:CCNJ
uniprot id: A0A4X1UHM5
names: Similarity
messages: Belongs to the cyclin family.

9823:BECN1
gene id: 9823:BECN1
uniprot id: A0A287BIH8
uniprot id: A0A4X1TXX7
uniprot id: Q4A1L5
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with African swine fever virus (ASFV) apoptosis regulator Bcl-2 homolog; this interaction allows the virus to inhibit BECN1, and thus autophagy.
messages: A homodimeric form is proposed to exist; this metastable form readily transits to ATG14- or UVRAG-containing complexes with BECN1:UVRAG being more stable than BECN1:ATG14 (By similarity). Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are PI3K complex I (PI3KC3-C1) containing ATG14, and PI3K complex II (PI3KC3-C2) containing UVRAG. PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex. Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits, such as RUBCN, SH3GLB1/Bif-1 and AMBRA1 (By similarity). PI3KC3-C1 probably associates with PIK3CB (By similarity). Interacts with AMBRA1, GOPC, GRID2 (By similarity). Forms a complex with PPP2CA and AMBRA1; AMBRA1 and BECN1 components of the complex regulate MYC stability via different pathways. Interacts with BCL2 and BCL2L1 isoform Bcl-X(L); the interaction inhibits BECN1 function in promoting autophagy by interfering with the formation of the PI3K complex. Interacts with cytosolic HMGB1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with USP10, USP13, VMP1, DAPK1, RAB39A. Interacts with the poly-Gln domain of ATXN3; the interaction causes deubiquitination at Lys-400 and stabilizes BECN1. Interacts with SLAMF1. Interacts with TRIM5; the interaction causes activation of BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Interacts with active ULK1 (phosphorylated on 'Ser-317') and MEFV simultaneously. Interacts with WDR81 and WDR91; negatively regulates the PI3 kinase/PI3K activity associated with endosomal membranes. Interacts with LAPTM4B; competes with…
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Expanded poly-Gln tracts inhibit ATXN3-BECN1 interaction, decrease BECN1 levels and impair starvation-induced autophagy (By similarity).
messages: Membrane
messages: Mitochondrion
messages: Mitochondrion membrane
messages: Nucleus
messages: Phosphorylation at Thr-117 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy. In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy.
messages: Plays a central role in autophagy.
messages: Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity).
messages: Polyubiquitinated by NEDD4, both with 'Lys-11'- and 'Lys-63'-linkages (By similarity). 'Lys-11'-linked polyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted (By similarity). Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes (By similarity). Polyubiquitinated at Lys-400 with 'Lys-48'-linkages (By similarity). 'Lys-48'-linked polyubiquitination of Lys-400 leads to degradation (By similarity). Deubiquitinated by ATXN3, leading to stabilization (By similarity). Ubiquitinated at Lys-435 via 'Lys-63'-linkage by the DCX(AMBRA1) complex, thereby increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity).
messages: Proteolytically processed by caspases including CASP8 and CASP3; the C-terminal fragments lack autophagy-inducing capacity and are proposed to induce apoptosis. Thus the cleavage is proposed to be an determinant to switch from autophagy to apoptosis pathways affecting cellular homeostasis including viral infections and survival of tumor cells.
messages: The C-terminal evolutionary conserved domain (ECD) contains poly-Gln-binding domains such as the ATXN3 poly-Gln motif, consistent with structural docking models revealing two highly scored poly-Gln-binding pockets in the ECD (By similarity). As some binding is observed with BECN1 lacking the ECD, other domains of BECN1 may also interact with ATXN3 (By similarity).
messages: autophagosome
messages: trans-Golgi network membrane

9823:UBE2K
gene id: 9823:UBE2K
uniprot id: A0A4X1V0N7
uniprot id: Q06AB2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:LOC100625207
gene id: 9823:LOC100625207
uniprot id: A0A480QWI2
names: Similarity
messages: Belongs to the peptidase C19 family.

9823:TM4SF20
gene id: 9823:TM4SF20
uniprot id: A0A8D0Z7Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9823:SLC5A6
gene id: 9823:SLC5A6
uniprot id: A0A8D1D4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9823:RPL35
gene id: 9823:RPL35
uniprot id: Q29361
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:RAD52
gene id: 9823:RAD52
uniprot id: A0A480VSL0
uniprot id: A0A4X1UGK6
uniprot id: B0M1M7
names: Similarity
messages: Belongs to the RAD52 family.

9823:SCAMP5
gene id: 9823:SCAMP5
uniprot id: A0A8D1WZ88
uniprot id: F1SJ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9823:ADRA2B
gene id: 9823:ADRA2B
uniprot id: A0A4X1VXR9
uniprot id: Q38PT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Membrane

9823:POLR1C
gene id: 9823:POLR1C
uniprot id: A0A286ZY98
uniprot id: A0A5G2R496
uniprot id: A0A8D1DU83
uniprot id: A0A8D1V2J3
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9823:BAIAP2
gene id: 9823:BAIAP2
uniprot id: A0A480P5D4
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9823:SMC4
gene id: 9823:SMC4
uniprot id: A0A480E9Z3
uniprot id: A0A4X1VG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

9823:PLD1
gene id: 9823:PLD1
uniprot id: A0A286ZZD3
uniprot id: A0A287A1P6
uniprot id: A0A4X1V5V7
uniprot id: A0A4X1VBT2
names: Similarity
messages: Belongs to the phospholipase D family.

9823:RAB18
gene id: 9823:RAB18
uniprot id: A0A4X1U5P7
uniprot id: I3LC07
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9823:MPZ
gene id: 9823:MPZ
uniprot id: F1S1B2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Homodimer and homotetramer.

9823:PRKAB1
gene id: 9823:PRKAB1
uniprot id: A0A4X1TVD6
uniprot id: A0A5G2QTQ1
uniprot id: A0A8D1LXQ5
uniprot id: F1RL45
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9823:SGCB
gene id: 9823:SGCB
uniprot id: B0FMQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

9823:KPNA3
gene id: 9823:KPNA3
uniprot id: A0A4X1SLI0
uniprot id: C6K7I1
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9823:ESRRA
gene id: 9823:ESRRA
uniprot id: A0A8D0P1K0
uniprot id: D2D3P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9823:HNRNPA3
gene id: 9823:HNRNPA3
uniprot id: A0A480W0D4
uniprot id: A0A4X1UJV5
uniprot id: F2Z5B4
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100511804
gene id: 9823:LOC100511804
uniprot id: A0A4X1UKN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:IARS2
gene id: 9823:IARS2
uniprot id: A0A480QG80
uniprot id: A0A8D1XWB4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9823:ARL3
gene id: 9823:ARL3
uniprot id: A0A480SIX0
uniprot id: Q52NJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cytoplasm
messages: Found in a complex with ARL3, RP2 and UNC119 (or UNC119B); RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119 (or UNC119B). Interacts with RP2; interaction is direct and stimulated with the activated GTP-bound form of ARL3. Interacts with SYS1. Interacts with ARL2BP; the GTP-bound form interacts with ARL2BP. Microtubule-associated protein. Does not interact with TBCC (By similarity). Interacts with RP2. Interacts with PDE6D; the interaction occurs specifically with the GTP-bound form of ARL3. Interacts with GGA1; the interaction recruits PKD1:PKD2 complex to trans-Golgi network and is required for ciliary targeting of PKD1:PKD2 complex (By similarity). Interacts with DNAAF9 (By similarity).
messages: Golgi apparatus membrane
messages: Nucleus
messages: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity).
messages: centrosome
messages: cilium
messages: spindle

9823:FLNC
gene id: 9823:FLNC
uniprot id: A0A287A8C2
uniprot id: A0A480U5F8
uniprot id: A0A8D0TZP9
uniprot id: A0A8D1F931
uniprot id: F1SMN5
names: Similarity
messages: Belongs to the filamin family.

9823:STAMBPL1
gene id: 9823:STAMBPL1
uniprot id: A0A480Y3D5
uniprot id: A0A4X1V134
names: Similarity
messages: Belongs to the peptidase M67C family.

9823:SCN4A
gene id: 9823:SCN4A
uniprot id: F1RSK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9823:GTF2H3
gene id: 9823:GTF2H3
uniprot id: A0A480XG24
uniprot id: A0A8D1BUF3
uniprot id: A0A8D1NEY2
uniprot id: F1RFL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9823:CACNB4
gene id: 9823:CACNB4
uniprot id: Q719N2
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9823:INHBB
gene id: 9823:INHBB
uniprot id: P04088
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9823:FCN2
gene id: 9823:FCN2
uniprot id: Q29041
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ficolin lectin family.
messages: Homotrimer. Interacts with elastin. Interacts with MASP1 and MASP2.
messages: Mainly expressed in skeletal muscle.
messages: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity).
messages: Secreted
messages: The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.

9823:VENTX
gene id: 9823:VENTX
uniprot id: A0A287A6P3
uniprot id: A0A8D1TW80
names: Subcellular Location Annotation
messages: Nucleus

9823:THEMIS2
gene id: 9823:THEMIS2
uniprot id: A0A481CJ62
names: Similarity
messages: Belongs to the themis family.

9823:ACVR1C
gene id: 9823:ACVR1C
uniprot id: A0A287AAP7
uniprot id: A0A4X1VP75
uniprot id: A0A8D1ZSH9
uniprot id: F1RPT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9823:KAT7
gene id: 9823:KAT7
uniprot id: A0A8D0ZA13
uniprot id: D3K5K8
uniprot id: M3VK28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9823:CAPRIN1
gene id: 9823:CAPRIN1
uniprot id: A0A4X1SSD2
uniprot id: F1SGS6
names: Similarity
messages: Belongs to the caprin family.

9823:UCP2
gene id: 9823:UCP2
uniprot id: A0A480XUE6
uniprot id: O97562
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a dimer forming a proton channel.
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).

9823:CHMP2B
gene id: 9823:CHMP2B
uniprot id: A0A287A1F6
uniprot id: A0A4X1UIP9
names: Similarity
messages: Belongs to the SNF7 family.

9823:NDUFB7
gene id: 9823:NDUFB7
uniprot id: A0A4X1V532
uniprot id: F1SCH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9823:GAST
gene id: 9823:GAST
uniprot id: P01351
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted
messages: Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.

9823:MGAT1
gene id: 9823:MGAT1
uniprot id: A0A4X1TB13
uniprot id: Q0KKC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9823:HOXB8
gene id: 9823:HOXB8
uniprot id: A0A4X1UQX1
names: Subcellular Location Annotation
messages: Nucleus

9823:GNAL
gene id: 9823:GNAL
uniprot id: A0A4X1VNM1
uniprot id: I3LK93
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9823:HNF4A
gene id: 9823:HNF4A
uniprot id: A0A288CG37
uniprot id: A0A8D1JH95
uniprot id: Q1I181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:PFDN5
gene id: 9823:PFDN5
uniprot id: A0A4X1WBA6
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9823:TUBA4A
gene id: 9823:TUBA4A
uniprot id: A0A286ZNY1
uniprot id: A0A4X1UG19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9823:CRISP2
gene id: 9823:CRISP2
uniprot id: A0A4X1UYQ4
uniprot id: B2ZGN2
uniprot id: F1RPZ6
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ANKS4B
gene id: 9823:ANKS4B
uniprot id: A0A8D1ZFU2
uniprot id: F1RPC7
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9823:ARAP2
gene id: 9823:ARAP2
uniprot id: A0A8D1QD97
uniprot id: F1S4M1
names: Subcellular Location Annotation
messages: Cytoplasm

9823:MIGA2
gene id: 9823:MIGA2
uniprot id: A0A8D1R099
names: Similarity
messages: Belongs to the mitoguardin family.

9823:TSSK6
gene id: 9823:TSSK6
uniprot id: A0A4X1TZ99
uniprot id: F1S6Q0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:BRMS1
gene id: 9823:BRMS1
uniprot id: A0A4X1TSR2
uniprot id: F1RUT0
names: Subcellular Location Annotation
messages: Nucleus

9823:NR4A3
gene id: 9823:NR4A3
uniprot id: A0A8D1S2T3
uniprot id: O97726
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:DCP1A
gene id: 9823:DCP1A
uniprot id: A0A8D1AZG7
names: Similarity
messages: Belongs to the DCP1 family.

9823:APOA1
gene id: 9823:APOA1
uniprot id: P18648
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Glycosylated.
messages: Homodimer (By similarity). Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity). Interacts with NAXE and YJEFN3 (By similarity).
messages: Liver apoa-I expressed in fetal, newborn and suckling animals. Intestinal apoA-I only expressed in postpartum animals.
messages: Major protein of plasma HDL, also found in chylomicrons. Synthesized predominantly in the intestine and the liver.
messages: Palmitoylated.
messages: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
messages: Phosphorylation sites are present in the extracellular medium.
messages: Secreted

9823:G6PC3
gene id: 9823:G6PC3
uniprot id: A0A4X1TS07
uniprot id: F1S1J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9823:HAP1
gene id: 9823:HAP1
uniprot id: A0A8D0Z706
uniprot id: F1S0M4
names: Subcellular Location Annotation
messages: Early endosome
messages: Mitochondrion

9823:AK6
gene id: 9823:AK6
uniprot id: A0A4X1UJ16
uniprot id: A0A5G2R3F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9823:MPP2
gene id: 9823:MPP2
uniprot id: A0A8D0XWB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9823:LRRC8B
gene id: 9823:LRRC8B
uniprot id: A0A480EQW0
uniprot id: A0A8D0YMX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9823:ZNF643
gene id: 9823:ZNF643
uniprot id: A0A8D0I1A5
uniprot id: A0A8D1H972
uniprot id: F1SCQ7
names: Subcellular Location Annotation
messages: Nucleus

9823:IGF2BP1
gene id: 9823:IGF2BP1
uniprot id: A0A4X1UNS5
uniprot id: I3L9X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9823:BLK
gene id: 9823:BLK
uniprot id: A0A481ASF4
uniprot id: A0A8D0I9S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:CCNB3
gene id: 9823:CCNB3
uniprot id: A0A4X1SQD0
uniprot id: A0A8D1IQY5
names: Similarity
messages: Belongs to the cyclin family.

9823:CXCL16
gene id: 9823:CXCL16
uniprot id: A0A8D0ZDM9
uniprot id: Q9GKE2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Glycosylated.
messages: Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity).
messages: Membrane

9823:GMPPA
gene id: 9823:GMPPA
uniprot id: A0A480QK53
uniprot id: A0A8D0U225
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9823:COLGALT1
gene id: 9823:COLGALT1
uniprot id: A0A287AXP9
uniprot id: A0A4X1UDT4
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9823:SIGMAR1
gene id: 9823:SIGMAR1
uniprot id: A0A287BCF9
uniprot id: A0A4X1US83
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

9823:LOC100523913
gene id: 9823:LOC100523913
uniprot id: A0A4X1VH61
uniprot id: A0A5G2R608
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ADIPOR1
gene id: 9823:ADIPOR1
uniprot id: A0A4X1V0U5
uniprot id: Q5V9L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:HIP1R
gene id: 9823:HIP1R
uniprot id: A0A4X1UGG6
uniprot id: F1REX8
names: Similarity
messages: Belongs to the SLA2 family.

9823:NXPE3
gene id: 9823:NXPE3
uniprot id: A0A480LFG9
uniprot id: A0A4X1SHH8
names: Similarity
messages: Belongs to the NXPE family.

9823:ATG2B
gene id: 9823:ATG2B
uniprot id: A0A8D1SGN7
uniprot id: D7RA36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9823:ZAN
gene id: 9823:ZAN
uniprot id: Q28983
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
messages: Cell membrane
messages: During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
messages: In testis, primarily in haploid spermatids. Not in lung, liver, heart, spleen, brain, kidney, epididymis.
messages: Probably forms covalent oligomers.
messages: The MAM domains and the mucin-like domains are missing from the zonadhesin that binds to the egg extracellular matrix. Processing might occur during sperm maturation and/or capacitation.
messages: The MAM domains probably mediate sperm adhesion to the zona pellucida.
messages: The VWFD domains 2 and 3 may mediate covalent oligomerization (By similarity to human intestinal mucin MUC2).

9823:SLC5A1
gene id: 9823:SLC5A1
uniprot id: A0A4X1V5B9
uniprot id: F1RLV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9823:TUBE1
gene id: 9823:TUBE1
uniprot id: A0A4X1V965
uniprot id: F1RZM6
names: Similarity
messages: Belongs to the tubulin family.

9823:APOB
gene id: 9823:APOB
uniprot id: A0A0F6TNY5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:KRT5
gene id: 9823:KRT5
uniprot id: A0A8D0KFL1
uniprot id: F1SGG6
names: Similarity
messages: Belongs to the intermediate filament family.

9823:GTF2H2
gene id: 9823:GTF2H2
uniprot id: A0A8D0RTU7
uniprot id: A0A8D1IWQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9823:RPL12
gene id: 9823:RPL12
uniprot id: A0A4X1U700
uniprot id: A0A5G2R7M9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9823:CNPY3
gene id: 9823:CNPY3
uniprot id: A5GFQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the canopy family.
messages: Endoplasmic reticulum
messages: Interacts with HSP90B1; this interaction is disrupted in the presence of ATP. Interacts with TLR1, TLR2, TLR4 and TLR9 (By similarity).
messages: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity).

9823:KIAA1324L
gene id: 9823:KIAA1324L
uniprot id: A0A480DMC3
uniprot id: A0A8D1HTB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9823:GLA
gene id: 9823:GLA
uniprot id: A0A8D1TEC6
uniprot id: D5FGE4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9823:ALOX15
gene id: 9823:ALOX15
uniprot id: A0A8D1LBM2
uniprot id: P16469
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Cell membrane
messages: Interacts with PEBP1; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid droplet
messages: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:8305485, PubMed:17493578, PubMed:18311922, PubMed:19324874). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:8305485, PubMed:17493578). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome prolifer…
messages: The PLAT domain can bind calcium ions; this promotes association with membranes.
messages: cytosol

9823:HMGCR
gene id: 9823:HMGCR
uniprot id: C7S800
uniprot id: Q1W675
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HMG-CoA reductase family.
messages: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.
messages: Endoplasmic reticulum membrane
messages: High expression found in liver, heart, kidney, bladder and subcutaneous fat. Lower levels in lung, uterus and large intestine. Lowest levels in cerebrum, spleen, spinal cord, stomach, ovary, longissimus muscle, and small intestine.
messages: Homotetramer. Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.
messages: Membrane
messages: N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.
messages: Peroxisome membrane
messages: Phosphorylated. Phosphorylation at Ser-869 reduces the catalytic activity.
messages: Regulated by a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate (By similarity). Phosphorylation at Ser-869 down-regulates the catalytic activity (By similarity).
messages: Undergoes sterol-mediated ubiquitination and ER-associated degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1 or INSIG2. The INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, RNF139 or RNF145, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. The INSIG2-binding leads to the recruitment of the ubiquitin ligase RNF139, initiating ubiquitination of the reductase. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.

9823:EZH1
gene id: 9823:EZH1
uniprot id: A0A8D0Y904
names: Subcellular Location Annotation
messages: Nucleus

9823:GLRA3
gene id: 9823:GLRA3
uniprot id: A0A287ABX9
uniprot id: A0A4X1V717
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9823:CLDN2
gene id: 9823:CLDN2
uniprot id: A0A4X1W6M4
uniprot id: C3VMK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:TOB1
gene id: 9823:TOB1
uniprot id: A0A4X1VBJ9
uniprot id: B2BE68
names: Similarity
messages: Belongs to the BTG family.

9823:NELFCD
gene id: 9823:NELFCD
uniprot id: A0A480NDK8
uniprot id: A5GFY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NELF-D family.
messages: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity).
messages: Nucleus
messages: The NELF complex is composed of NELFA, NELFB, NELFCD and NELFE; NELFA and NELFCD form a stable subcomplex that binds primarily through NELFCD to the N-terminus of NELFB (By similarity). Binds RNA which may help to stabilize the NELF complex on nucleic acid (By similarity). In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner (By similarity). Interacts with ARAF1 (By similarity). Interacts with PCF11 (By similarity). Interacts with NELFB (By similarity). Interacts with KAT8 (By similarity).

9823:GEM
gene id: 9823:GEM
uniprot id: A0A4X1U1R7
uniprot id: A0A4X1U6D0
uniprot id: F1RY50
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9823:C7H14orf1
gene id: 9823:C7H14orf1
uniprot id: A0A8D1JA86
uniprot id: D0G0B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:DLX1
gene id: 9823:DLX1
uniprot id: A0A481C382
uniprot id: A0A4X1V5H4
names: Subcellular Location Annotation
messages: Nucleus

9823:MMP20
gene id: 9823:MMP20
uniprot id: P79287
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autoactivates at least at the 107-Asn-|-Tyr-108 site.
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Calcium ions per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).
messages: Expressed specifically in the enamel organ.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

9823:NECTIN1
gene id: 9823:NECTIN1
uniprot id: Q9GL76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nectin family.
messages: Cell membrane
messages: Interacts with HSV glycoprotein D (gD).
messages: Probably involved in cell adhesion. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells.

9823:TBX18
gene id: 9823:TBX18
uniprot id: A0A8D0YZU9
uniprot id: F1S0I2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:COPZ1
gene id: 9823:COPZ1
uniprot id: A0A8D0YLP9
uniprot id: A0A8D1YTE6
uniprot id: F2Z5S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9823:LOC100624876
gene id: 9823:LOC100624876
uniprot id: A0A8D1XAK3
uniprot id: I3LQ89
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CYP2C42
gene id: 9823:CYP2C42
uniprot id: A0A480QNA8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:IFN-DELTA-6
gene id: 9823:IFN-DELTA-6
uniprot id: A0A4X1WDG0
uniprot id: C8CKB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:SLC39A14
gene id: 9823:SLC39A14
uniprot id: A0A480VPG4
uniprot id: A0A4X1VFS0
uniprot id: A0A4X1VGR6
names: Subcellular Location Annotation
messages: Membrane

9823:SNF8
gene id: 9823:SNF8
uniprot id: A0A4X1UL97
uniprot id: I3L6X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

9823:PPP1R16B
gene id: 9823:PPP1R16B
uniprot id: A0A8D1WB37
uniprot id: F1SDW9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:LOC100620249
gene id: 9823:LOC100620249
uniprot id: A0A8D1N3T0
uniprot id: F1S636
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:TRIM10
gene id: 9823:TRIM10
uniprot id: A0A8D1SJK9
uniprot id: B6ICU9
uniprot id: F1RZ50
uniprot id: O19085
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association of TYK2 and IFNAR1 (By similarity).
messages: Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2.

9823:SRPX
gene id: 9823:SRPX
uniprot id: A0A4X1U3P4
uniprot id: A0A4X1U8J2
uniprot id: F1RXR1
uniprot id: K7GKF8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:RAE1
gene id: 9823:RAE1
uniprot id: A0A480UJG9
uniprot id: A5GFN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat rae1 family.
messages: Cytoplasm
messages: Interacts with NUMA1 (via N-terminal end of the coiled-coil domain); this interaction promotes spindle formation in mitosis (By similarity). Interacts with NUP98 (By similarity). Interacts with MYCBP2 (By similarity). Interacts with USP11 (By similarity).
messages: Nucleus
messages: Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
messages: spindle pole

9823:MS4A12
gene id: 9823:MS4A12
uniprot id: A0A8D1D195
names: Similarity
messages: Belongs to the MS4A family.

9823:NDUFC2
gene id: 9823:NDUFC2
uniprot id: A0A480JRW3
uniprot id: A0A4X1UCN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9823:LOC100522787
gene id: 9823:LOC100522787
uniprot id: A0A480T933
uniprot id: A0A4X1U2L2
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:CDH24
gene id: 9823:CDH24
uniprot id: A0A4X1V5K2
uniprot id: F1S9C8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9823:LOC100626599
gene id: 9823:LOC100626599
uniprot id: A0A5G2QYK1
uniprot id: A0A8D1EA98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ASRGL1
gene id: 9823:ASRGL1
uniprot id: A0A4X1VNE4
uniprot id: A0A8D1XME1
uniprot id: F1RPW8
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9823:CUL9
gene id: 9823:CUL9
uniprot id: A0A287AWA8
uniprot id: I3LD80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9823:FZD10
gene id: 9823:FZD10
uniprot id: A0A8D1RLN6
uniprot id: F1RFQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9823:LOC100522130
gene id: 9823:LOC100522130
uniprot id: A0A287AAP0
uniprot id: A0A4X1VWX3
names: Similarity
messages: Belongs to the FAH family.

9823:RPS3
gene id: 9823:RPS3
uniprot id: Q0Z8U2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the 40S small ribosomal subunit. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with HNRPD. Interacts with PRMT1; the interaction methylates RPS3. Interacts with SUMO1; the interaction sumoylates RPS3. Interacts with UBC9. Interacts with CDK1; the interaction phosphorylates RPS3. Interacts with PRKCD; the interaction phosphorylates RPS3. Interacts with PKB/AKT; the interaction phosphorylates RPS3. Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity. Interacts with UNG; the interaction increases the uracil excision activity of UNG1. Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels. Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion. Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex. Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA. Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus. Interacts (via KH domain) with MDM2 and TP53. Interacts with TRADD. Interacts with CRY1.
messages: Cytoplasm
messages: Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiester backbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes. Represses its own translation by binding to its cognate mRNA. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization. Involved in induction of apoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation.
messages: Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.
messages: Mitochondrion inner membrane
messages: Nucleus
messages: Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase. Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity. Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3. Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide. Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis.
messages: Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.
messages: Ubiquitinated. This is prevented by interaction with HSP90 which stabilizes the protein. Monoubiquitinated at Lys-214 by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide.
messages: Ufmylated by UFL1.
messages: nucleolus
messages: spindle

9823:GLP2R
gene id: 9823:GLP2R
uniprot id: F8V3Z1
names: Subcellular Location Annotation
messages: Membrane

9823:TGFB3
gene id: 9823:TGFB3
uniprot id: A0A8D1N627
uniprot id: K7GSJ9
uniprot id: P15203
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Interacts with ASPN (By similarity). Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide: Interacts with Transforming growth factor beta-3 (TGF-beta-3) chain; interaction is non-covalent and maintains (TGF-beta-3) in a latent state (By similarity). Latency-associated peptide: Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-3 and promote epithelial fusion during palate development (By similarity). Latency-associated peptide: Interacts (via cell attachment site) with integrins, leading to release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-3: Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
messages: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity).
messages: Secreted
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: Transforming growth factor beta-3 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-3 (TGF-beta-3) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-3 inactive.
messages: Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).
messages: extracellular matrix

9823:RRAGD
gene id: 9823:RRAGD
uniprot id: A0A481CHT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9823:PIN4
gene id: 9823:PIN4
uniprot id: A0A4X1W136
uniprot id: I3LBW5
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

9823:SLC25A35
gene id: 9823:SLC25A35
uniprot id: A0A286ZTW6
uniprot id: A0A481CH68
uniprot id: A0A8D1LA58
uniprot id: A0A8D1W4W6
uniprot id: A0A8D2BPM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:TRIT1
gene id: 9823:TRIT1
uniprot id: A0A480EF58
uniprot id: A0A8D0V0X6
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9823:BDKRB1
gene id: 9823:BDKRB1
uniprot id: Q8HZN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
messages: Cell membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9823:SGCD
gene id: 9823:SGCD
uniprot id: A0A4X1TUU5
uniprot id: B8Y4S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9823:LAPTM4A
gene id: 9823:LAPTM4A
uniprot id: A0A4X1U6W0
uniprot id: I3LPB3
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9823:LOC106504905
gene id: 9823:LOC106504905
uniprot id: A0A5G2QWZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:QKI
gene id: 9823:QKI
uniprot id: M3UZ14
uniprot id: Q5W9D5
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity).
messages: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1.
messages: Methylated by PRMT1.
messages: Nucleus
messages: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
messages: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
messages: The KH domain and the Qua2 region are involved in RNA binding.
messages: Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).

9823:TMEM229B
gene id: 9823:TMEM229B
uniprot id: A0A4X1U8L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9823:SERBP1
gene id: 9823:SERBP1
uniprot id: A0A4X1V0E9
uniprot id: A0A8D1EX64
uniprot id: F1S827
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:GIF
gene id: 9823:GIF
uniprot id: A0A8D0UPJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9823:GLDN
gene id: 9823:GLDN
uniprot id: A0A4X1SZI4
uniprot id: F1RYN3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DEDD
gene id: 9823:DEDD
uniprot id: A0A4X1VT31
uniprot id: F1S193
names: Subcellular Location Annotation
messages: nucleolus

9823:CCR4
gene id: 9823:CCR4
uniprot id: A0A286ZR23
uniprot id: A0A4X1U8L0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:TNF
gene id: 9823:TNF
uniprot id: B3GDZ6
uniprot id: P23563
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9823:C1QA
gene id: 9823:C1QA
uniprot id: Q69DL0
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain. Interacts (via C-terminus) with CD33; this interaction activates CD33 inhibitory motifs.
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
messages: O-linked glycans are Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains.
messages: Proline residues in the collagen-like domain motif, GXPG, are typically 4-hydroxylated.
messages: Secreted

9823:ZSCAN9
gene id: 9823:ZSCAN9
uniprot id: A0A4X1VF90
names: Subcellular Location Annotation
messages: Nucleus

9823:BOLA1
gene id: 9823:BOLA1
uniprot id: A0A8D1AA70
names: Similarity
messages: Belongs to the BolA/IbaG family.

9823:ATIC
gene id: 9823:ATIC
uniprot id: A0A4X1UQT7
uniprot id: B3VMR0
names: Similarity
messages: Belongs to the PurH family.

9823:GALNT8
gene id: 9823:GALNT8
uniprot id: A0A8D1RQM7
uniprot id: F1SL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9823:EFS
gene id: 9823:EFS
uniprot id: A0A4X1SFH2
uniprot id: A0A4X1SG19
uniprot id: F1S9E1
names: Similarity
messages: Belongs to the CAS family.

9823:ABCG2
gene id: 9823:ABCG2
uniprot id: Q8MIB3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (PubMed:12054514). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (By similarity). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation (By similarity).
messages: Cell membrane
messages: High expression in brain, kidney and lung. Also expressed in livere, colon, small intestine, heart, skeletal muscle, spleen, stomach and pancreas.
messages: Homodimer; disulfide-linked. The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers.
messages: Mitochondrion membrane
messages: N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional.
messages: Phosphorylated. Phosphorylation may regulate the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.
messages: The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.

9823:PDHA1
gene id: 9823:PDHA1
uniprot id: A0A480VQH5
uniprot id: A0A4X1V4S1
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9823:KEF22 p08
gene id: 9823:KEF22_p08
uniprot id: Q35915
uniprot id: Q71K73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9823:OCA2
gene id: 9823:OCA2
uniprot id: Q8MIQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation. One of the components of the mammalian pigmentary system. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color (By similarity). Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis (By similarity).
messages: Melanosome membrane

9823:GPR65
gene id: 9823:GPR65
uniprot id: A0A4X1T012
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:FOXK2
gene id: 9823:FOXK2
uniprot id: A0A8D2BVT5
names: Subcellular Location Annotation
messages: Nucleus

9823:ARFGEF2
gene id: 9823:ARFGEF2
uniprot id: A0A5G2QXW0
uniprot id: A0A8D1RFB5
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9823:ATP6V1C2
gene id: 9823:ATP6V1C2
uniprot id: A0A287ATX8
uniprot id: A0A8D0UFP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9823:PAN2
gene id: 9823:PAN2
uniprot id: A0A287AC03
uniprot id: A0A287BP02
uniprot id: A0A4X1W369
uniprot id: A0A4X1W8L2
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9823:PGC
gene id: 9823:PGC
uniprot id: A0A286ZP41
uniprot id: A0A4X1SIQ7
uniprot id: A0A4X1SIV5
uniprot id: F1RUW7
names: Function
names: Similarity
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.

9823:IMPDH2
gene id: 9823:IMPDH2
uniprot id: A0A4X1SZ57
uniprot id: F1SKI5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9823:LOC100512174
gene id: 9823:LOC100512174
uniprot id: A5A8X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9823:LOC100738816
gene id: 9823:LOC100738816
uniprot id: A0A8D1KKB3
uniprot id: F1RMQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TBC1D7
gene id: 9823:TBC1D7
uniprot id: A0A287A809
uniprot id: A0A4X1VJN5
uniprot id: A0A4X1VQ82
uniprot id: F1RV80
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9823:FAM109A
gene id: 9823:FAM109A
uniprot id: A0A4X1U2T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9823:TJP2
gene id: 9823:TJP2
uniprot id: A0A287AQX9
uniprot id: A0A287AZ07
uniprot id: A0A287BAI8
uniprot id: A0A8D0KCG1
uniprot id: A0A8D0KE98
uniprot id: F1SJE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9823:PKD1
gene id: 9823:PKD1
uniprot id: F4NA29
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:PPAN
gene id: 9823:PPAN
uniprot id: A0A4X1UXW0
uniprot id: F1S3I2
names: Subcellular Location Annotation
messages: nucleolus

9823:CDX4
gene id: 9823:CDX4
uniprot id: A0A4X1VW22
uniprot id: I3L5H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9823:SLA-DQB1
gene id: 9823:SLA-DQB1
uniprot id: P15982
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class II family.
messages: Membrane

9823:GPRASP1
gene id: 9823:GPRASP1
uniprot id: A0A8D1ALK9
uniprot id: F1RYE9
names: Similarity
messages: Belongs to the GPRASP family.

9823:BMX
gene id: 9823:BMX
uniprot id: A0A8D1ICW6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9823:ODAM
gene id: 9823:ODAM
uniprot id: Q003G9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: O-glycosylated.
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

9823:PLCZ1
gene id: 9823:PLCZ1
uniprot id: Q7YRU3
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed specifically in testis.
messages: In testes, detected only when the elongated spermatids have differentiated from 96 days after birth.
messages: Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
messages: Nucleus
messages: The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.
messages: The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
messages: perinuclear region

9823:LOC100157720
gene id: 9823:LOC100157720
uniprot id: F1SP66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PDE4D
gene id: 9823:PDE4D
uniprot id: A0A8D1GF51
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9823:ZDHHC15
gene id: 9823:ZDHHC15
uniprot id: A0A286ZRJ4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:PFN1
gene id: 9823:PFN1
uniprot id: A0A4X1UWL6
names: Similarity
messages: Belongs to the profilin family.

9823:TCF7L2
gene id: 9823:TCF7L2
uniprot id: A0A480INH7
uniprot id: A0A480M1C5
uniprot id: A0A480TIN0
uniprot id: A0A480VX01
uniprot id: A0A480W0L5
uniprot id: A0A480W530
uniprot id: A0A480XWX5
uniprot id: A0A481CE29
uniprot id: A0A8D0WBI5
uniprot id: A0A8D1C4X1
uniprot id: A0A8D1HHN8
uniprot id: A0A8D1VUL1
uniprot id: A0A8D1ZH26
uniprot id: F1S5J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9823:SOCS2
gene id: 9823:SOCS2
uniprot id: Q7YRV6
names: Domain
names: Function
names: PTM
names: Subunit
messages: Interacts with IGF1R (By similarity). Associates with the Elongin BC complex (By similarity). Interacts with AREL1 and PRKCA (By similarity). Interacts with DCUN1D1 (By similarity).
messages: Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteosomal degradation.
messages: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
messages: Ubiquitinated; mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on phosphorylation at Ser-52, by PKC and is stimulated by LPS.

9823:CEP76
gene id: 9823:CEP76
uniprot id: A0A480QQC8
uniprot id: A0A4X1VTN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

9823:HGH1
gene id: 9823:HGH1
uniprot id: A0A287AMW7
uniprot id: A0A8D1SGF6
names: Similarity
messages: Belongs to the HGH1 family.

9823:AMT
gene id: 9823:AMT
uniprot id: A0A4X1SUG2
uniprot id: I3LIR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9823:ANO4
gene id: 9823:ANO4
uniprot id: A0A4X1SW93
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:EBPL
gene id: 9823:EBPL
uniprot id: A0A4X1SL82
uniprot id: F1RK22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:NUBP1
gene id: 9823:NUBP1
uniprot id: A0A480QFS8
uniprot id: A0A5G2RCL1
uniprot id: A0A8D1A987
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9823:MAB21L1
gene id: 9823:MAB21L1
uniprot id: A0A8D0ZIJ2
names: Similarity
messages: Belongs to the mab-21 family.

9823:NTS
gene id: 9823:NTS
uniprot id: A0A4X1UZ84
uniprot id: F1SPX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9823:FAM162B
gene id: 9823:FAM162B
uniprot id: A0A4X1TCM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9823:PRKG2
gene id: 9823:PRKG2
uniprot id: A0A4X1SZN2
uniprot id: F1RVC8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9823:KLC4
gene id: 9823:KLC4
uniprot id: A0A8D1IRC0
uniprot id: F1RRN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9823:RNASET2
gene id: 9823:RNASET2
uniprot id: A0A5G2QZM3
uniprot id: A0A8D1SJR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Lysosome lumen

9823:MRPS5
gene id: 9823:MRPS5
uniprot id: A0A4X1VX14
uniprot id: F1SU66
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9823:HDAC3
gene id: 9823:HDAC3
uniprot id: A0A480Q1X2
uniprot id: A0A8D0JH86
uniprot id: A0A8D1F8K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

9823:SENP7
gene id: 9823:SENP7
uniprot id: A0A287A2Z8
uniprot id: A0A287A739
uniprot id: A0A4X1UUZ5
uniprot id: A0A4X1UX12
uniprot id: A0A4X1UZY4
uniprot id: A0A8D1TIF2
uniprot id: I3LG40
names: Similarity
messages: Belongs to the peptidase C48 family.

9823:IFN-DELTA-1
gene id: 9823:IFN-DELTA-1
uniprot id: Q29114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:AGK
gene id: 9823:AGK
uniprot id: A0A8D1RDJ7
uniprot id: B8XSJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9823:LOC100520926
gene id: 9823:LOC100520926
uniprot id: A0A8D0QVD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLCO2A1
gene id: 9823:SLCO2A1
uniprot id: A0A4X1TUR3
uniprot id: Q2QEH5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:MARCKSL1
gene id: 9823:MARCKSL1
uniprot id: A0A4X1W0E6
names: Similarity
messages: Belongs to the MARCKS family.

9823:LOC100516990
gene id: 9823:LOC100516990
uniprot id: A0A286ZW50
uniprot id: A0A4X1VDB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100737570
gene id: 9823:LOC100737570
uniprot id: A0A4X1U1W4
uniprot id: A0A5G2QL45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MARCO
gene id: 9823:MARCO
uniprot id: A0A4X1SMC4
uniprot id: H2F098
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:SLC10A4
gene id: 9823:SLC10A4
uniprot id: A0A4X1UKK1
uniprot id: F1SEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9823:GLMP
gene id: 9823:GLMP
uniprot id: A0A5G2QC45
uniprot id: A0A8D0QMJ2
uniprot id: A0A8D1IX48
uniprot id: F1RP16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9823:LOC100152956
gene id: 9823:LOC100152956
uniprot id: A0A287A549
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ORC4
gene id: 9823:ORC4
uniprot id: A0A4X1TGG4
uniprot id: A0A4X1THM5
uniprot id: F1S0H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9823:LOC100512466
gene id: 9823:LOC100512466
uniprot id: A0A4X1W9W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLC4A7
gene id: 9823:SLC4A7
uniprot id: M3V864
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9823:GPR34
gene id: 9823:GPR34
uniprot id: A0A4X1VHZ1
uniprot id: I3LGG4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:RAB39A
gene id: 9823:RAB39A
uniprot id: A0A287A5W5
uniprot id: A0A4X1VI77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9823:PRDM4
gene id: 9823:PRDM4
uniprot id: A0A286ZM81
uniprot id: A0A8D1QTC8
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

9823:LIPE
gene id: 9823:LIPE
uniprot id: A0A8D1L7S7
uniprot id: A0A8D1PVS2
uniprot id: Q68J42
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (By similarity). Shows a preferential hydrolysis of DAGs over TAGs and MAGs (By similarity). Preferentially hydrolyzes fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs and FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity).
messages: Lipid droplet
messages: Monomer and homodimer (By similarity). Interacts with CAVIN1 in the adipocyte cytoplasm (By similarity). Interacts with PLIN5 (By similarity).
messages: Phosphorylation by AMPK reduces its translocation towards the lipid droplets.
messages: caveola
messages: cytosol

9823:BTG2
gene id: 9823:BTG2
uniprot id: A4UTQ1
names: Similarity
messages: Belongs to the BTG family.

9823:DNTTIP1
gene id: 9823:DNTTIP1
uniprot id: A0A4X1U011
uniprot id: F1SC86
names: Subcellular Location Annotation
messages: Nucleus

9823:EIF4EBP3
gene id: 9823:EIF4EBP3
uniprot id: A0A4X1SEI3
uniprot id: I3LLK9
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9823:TMEM138
gene id: 9823:TMEM138
uniprot id: A0A480W4G0
uniprot id: A0A8D1J2Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9823:LOC100511937
gene id: 9823:LOC100511937
uniprot id: A0A4X1W4S4
uniprot id: A0A5G2QG64
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9823:DDRGK1
gene id: 9823:DDRGK1
uniprot id: A0A287BPF3
uniprot id: A0A8D1ZLK5
names: Similarity
messages: Belongs to the DDRGK1 family.

9823:TF
gene id: 9823:TF
uniprot id: A0A8D0PY93
uniprot id: B3CL06
uniprot id: Q29545
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transferrin family.
messages: Blood plasma.
messages: Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions.
messages: Monomer.
messages: Monomer. Interacts (via transferrin-like domain 2) with CA2. Has nanomolar affinity for CA2.
messages: N-glycosylated.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

9823:C4BPB
gene id: 9823:C4BPB
uniprot id: A0A4X1UPT7
uniprot id: F1S0J3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:HSD17B2
gene id: 9823:HSD17B2
uniprot id: D0G6Y1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:ABRAXAS1
gene id: 9823:ABRAXAS1
uniprot id: A0A8D0MVG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
messages: Nucleus

9823:GBP1
gene id: 9823:GBP1
uniprot id: B2XWS1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9823:ZNF706
gene id: 9823:ZNF706
uniprot id: A0A4X1TUR5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:CCL3L1
gene id: 9823:CCL3L1
uniprot id: Q6DUK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:RBM48
gene id: 9823:RBM48
uniprot id: A0A8D0RME0
uniprot id: F1SFC8
names: Similarity
messages: Belongs to the RBM48 family.

9823:HARS
gene id: 9823:HARS
uniprot id: A0A8D2AAA4
uniprot id: F1RGD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9823:LOC100523745
gene id: 9823:LOC100523745
uniprot id: A0A8D1WAT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9823:GJB7
gene id: 9823:GJB7
uniprot id: A0A287BK92
uniprot id: A0A8D1PKG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:GALNTL5
gene id: 9823:GALNTL5
uniprot id: A0A4X1UI21
uniprot id: F1SSN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

9823:LOC102163847
gene id: 9823:LOC102163847
uniprot id: A0A4X1VEM7
uniprot id: F1RT21
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9823:CRHR1
gene id: 9823:CRHR1
uniprot id: B8Q4Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
messages: Membrane

9823:HSP70.2
gene id: 9823:HSP70.2
uniprot id: A5A8V6
uniprot id: Q6S4N2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.
messages: May be an auxiliary component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with METTL21A. Interacts with TRIM5 (via B30.2/SPRY domain). Interacts with PRKN. Interacts with FOXP3. Interacts with NOD2; the interaction enhances NOD2 stability. Interacts with DNAJC9 (via J domain). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively. Interacts with NEDD1 and SMAD3. Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105. Interacts with DNAJC8.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein re…
messages: Testis-specific.
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
messages: centrosome

9823:RPS26
gene id: 9823:RPS26
uniprot id: P49171
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9823:LOC102165039
gene id: 9823:LOC102165039
uniprot id: A0A4X1TJ62
uniprot id: F1RR01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9823:SCRN2
gene id: 9823:SCRN2
uniprot id: F1RWI8
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9823:ATPIF1
gene id: 9823:ATPIF1
uniprot id: Q29307
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme (By similarity).
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil composed of residues 74-106, leaving each N-terminal inhibitory region (residues 26-52) accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region (residues 26-52) binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity (By similarity).
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0 (By similarity).
messages: Mitochondrion

9823:HVCN1
gene id: 9823:HVCN1
uniprot id: A0A4X1U1H6
uniprot id: F1RNL6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9823:LOC100517149
gene id: 9823:LOC100517149
uniprot id: A0A480EGR6
uniprot id: A0A8D1CVK8
uniprot id: A0A8D1X7Y9
names: Subcellular Location Annotation
messages: Nucleus

9823:SLC4A4
gene id: 9823:SLC4A4
uniprot id: Q4U116
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
messages: Expressed in vas deferens epithelia (at protein level).
messages: Homodimer. Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity. Isoform 1 but not isoform 2 interacts with AHCYL1 (via PEST domain when phosphorylated); the interaction increases SLC4A4 isoform 1 activity. Interacts with AHCYL2.
messages: N-glycosylated. May not be necessary for the transporter basic functions.
messages: Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase; phosphorylation seems to inhibit SLC4A4 activity.

9823:TMEM184A
gene id: 9823:TMEM184A
uniprot id: A0A8D1GUB8
uniprot id: A0A8D1YBD8
uniprot id: F1RIV1
names: Subcellular Location Annotation
messages: Membrane

9823:USP45
gene id: 9823:USP45
uniprot id: A0A8D1Y7P9
uniprot id: F1RXY2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:LOC100515784
gene id: 9823:LOC100515784
uniprot id: A0A8D1CY71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100514087
gene id: 9823:LOC100514087
uniprot id: A0A287BI54
uniprot id: A0A4X1W9L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLA-DQA1
gene id: 9823:SLA-DQA1
uniprot id: Q6JHY7
uniprot id: Q7YQ90
names: Similarity
messages: Belongs to the MHC class II family.

9823:CYBA
gene id: 9823:CYBA
uniprot id: P52650
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A (By similarity). Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX3 and NOX4. Interacts with calprotectin (S100A8/9) (By similarity). Interacts with GBP7 (By similarity).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding.
messages: The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome b-245.
messages: Ubiquitinated at Lys-149 likely by RNF145.

9823:SLC25A48
gene id: 9823:SLC25A48
uniprot id: A0A480JMW9
uniprot id: A0A480PVT9
uniprot id: A0A8D0X2V3
uniprot id: A0A8D1KY63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:ATP5S
gene id: 9823:ATP5S
uniprot id: A0A286ZRY7
uniprot id: A0A4X1SG93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion inner membrane

9823:PITPNM2
gene id: 9823:PITPNM2
uniprot id: A0A480THL1
uniprot id: A0A8D1JJ47
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9823:STRN4
gene id: 9823:STRN4
uniprot id: A0A4X1VW91
uniprot id: F1RM09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9823:CDK4
gene id: 9823:CDK4
uniprot id: P79432
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Both phosphorylation at Thr-172 and binding of a D-type cyclin are necessary for enzymatic activity. Full activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. Inhibited by INK4 family members. In resting cells, the non-tyrosine-phosphorylated form of CDKN1B prevents phosphorylation at Thr-172 and inactivation, while, in proliferating cells, tyrosine phosphorylation of CDKN1B allows phosphorylation of Thr-172 of CDK4 and subsequent activation.
messages: Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3). Interacts directly in the complex with CCND1, CCND2 or CCND3. Interacts with SEI1 and ZNF655. Forms a ternary complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity. Interacts directly with CDKN1B (phosphorylated on 'Tyr-88' and 'Tyr-89'); the interaction allows assembly of the cyclin D-CDK4 complex, Thr-172 phosphorylation, nuclear translocation and enhances the cyclin D-CDK4 complex activity. CDK4 activity is either inhibited or enhanced depending on stoichiometry of complex. The non-tyrosine-phosphorylated form of CDKN1B prevents T-loop phosphorylation of CDK4 producing inactive CDK4. Interacts (unphosphorylated form) with CDK2. Also forms ternary complexes with CDKN1A or CDKN2A. Interacts directly with CDKN1A (via its N-terminal); the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Interacts with CCND1; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Interacts with CEBPA (when phosphorylated). Interacts with FNIP1 and FNIP2.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus membrane
messages: Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B (By similarity).
messages: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

9823:GLG1
gene id: 9823:GLG1
uniprot id: A0A8D2CFE8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

9823:DYNLT3
gene id: 9823:DYNLT3
uniprot id: A0A4X1VCQ2
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9823:KCNE5
gene id: 9823:KCNE5
uniprot id: A0A287B4W1
uniprot id: A0A8D1D0Z6
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9823:RPN2
gene id: 9823:RPN2
uniprot id: Q9GL01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with DDI2 (By similarity). Interacts with TMEM35A/NACHO (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9823:ELSPBP1
gene id: 9823:ELSPBP1
uniprot id: A0A4X1W0U4
uniprot id: I3LCL7
uniprot id: Q7YR83
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the seminal plasma protein family.
messages: Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity.
messages: Detected in epididymal duct epithelium and on sperm membrane (at protein level).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Not N-glycosylated.
messages: Secreted

9823:FAM216A
gene id: 9823:FAM216A
uniprot id: A0A4X1U495
uniprot id: F1RNN1
names: Similarity
messages: Belongs to the FAM216 family.

9823:C2H11orf49
gene id: 9823:C2H11orf49
uniprot id: A0A480UYS9
uniprot id: A0A4X1VTB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: centriolar satellite

9823:MAP4
gene id: 9823:MAP4
uniprot id: A0A286ZXD9
uniprot id: A0A8D0QTZ3
uniprot id: A0A8D1XAI2
uniprot id: F1SLI3
names: Subcellular Location Annotation
messages: cytoskeleton

9823:GRPR
gene id: 9823:GRPR
uniprot id: A0A4X1UXD7
uniprot id: K7GR81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:AMBN
gene id: 9823:AMBN
uniprot id: Q28989
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Ameloblast-specific. Located at the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel.
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

9823:MAGT1
gene id: 9823:MAGT1
uniprot id: A0A4X1W223
uniprot id: K7GKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:BMP5
gene id: 9823:BMP5
uniprot id: A0A059NTB8
uniprot id: A0A4X1UQQ8
names: Similarity
messages: Belongs to the TGF-beta family.

9823:FOXR1
gene id: 9823:FOXR1
uniprot id: A0A8D1RVB7
uniprot id: F1SAJ1
names: Subcellular Location Annotation
messages: Nucleus

9823:MRPL58
gene id: 9823:MRPL58
uniprot id: A0A286ZJR2
uniprot id: A0A4X1V0P7
names: Subcellular Location Annotation
messages: Mitochondrion

9823:CMTM5
gene id: 9823:CMTM5
uniprot id: A0A8D1Y371
names: Subcellular Location Annotation
messages: Membrane

9823:CD163L1
gene id: 9823:CD163L1
uniprot id: Q29113
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:SFTPC
gene id: 9823:SFTPC
uniprot id: A0A8D1U838
uniprot id: Q3MSM2
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: surface film

9823:TATDN2
gene id: 9823:TATDN2
uniprot id: A0A8D0J6H8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9823:TAS2R38
gene id: 9823:TAS2R38
uniprot id: A0A8D0ZY27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9823:EPO
gene id: 9823:EPO
uniprot id: P49157
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
messages: Secreted

9823:KEF22 p13
gene id: 9823:KEF22_p13
uniprot id: A0A0U1RS44
uniprot id: A0A4X1WD94
uniprot id: O79874
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9823:FAM174B
gene id: 9823:FAM174B
uniprot id: A0A4X1UCT1
uniprot id: A0A8D1XSW2
uniprot id: F1SA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9823:LOC100520241
gene id: 9823:LOC100520241
uniprot id: A0A4X1VV56
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GAR1
gene id: 9823:GAR1
uniprot id: A0A4X1UY81
uniprot id: I3LVQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9823:WAP
gene id: 9823:WAP
uniprot id: O46655
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Could be a protease inhibitor. May play an important role in mammary gland development and tissue remodeling.
messages: Milk-specific; major protein component of milk whey.
messages: Secreted

9823:SORBS2
gene id: 9823:SORBS2
uniprot id: A0A286ZN88
names: Subcellular Location Annotation
messages: focal adhesion

9823:HTR7
gene id: 9823:HTR7
uniprot id: A0A480JFG1
uniprot id: A0A8D0QU38
uniprot id: Q8SPH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:TACSTD2
gene id: 9823:TACSTD2
uniprot id: A0A8D1BAJ3
uniprot id: F1S7A4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:MOGS
gene id: 9823:MOGS
uniprot id: A0A8D1FC89
uniprot id: K7N7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9823:CYP26A1
gene id: 9823:CYP26A1
uniprot id: A0A0H4IQJ4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:UHRF1
gene id: 9823:UHRF1
uniprot id: A0A480LXY4
uniprot id: A0A8D0X9J9
names: Subcellular Location Annotation
messages: Nucleus

9823:SMO
gene id: 9823:SMO
uniprot id: A0A8D1ZBL7
uniprot id: F1SMQ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:KIT
gene id: 9823:KIT
uniprot id: Q2HWD6
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3 catalytic subunit. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
messages: Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.
messages: Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Activity is down-regulated by PRKCA-mediated phosphorylation on serine residues (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).
messages: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation.

9823:YIPF3
gene id: 9823:YIPF3
uniprot id: A0A4X1V8L1
uniprot id: A0A8D1JPW8
uniprot id: F1RRJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

9823:LOC100515362
gene id: 9823:LOC100515362
uniprot id: A0A4X1U1P6
uniprot id: F1S6N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RNF157
gene id: 9823:RNF157
uniprot id: A0A4X1UXB9
uniprot id: F1RWM8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9823:CPLX3
gene id: 9823:CPLX3
uniprot id: A0A8D0VSP4
uniprot id: F1SJ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9823:GABBR1
gene id: 9823:GABBR1
uniprot id: A0A4X1VL73
uniprot id: F1RYH7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DPY19L4
gene id: 9823:DPY19L4
uniprot id: A0A287BP67
uniprot id: A0A4X1TZ69
uniprot id: A0A8D0TZR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9823:FGF13
gene id: 9823:FGF13
uniprot id: A0A4X1SHL0
uniprot id: A0A5G2R0Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: dendrite
messages: filopodium
messages: growth cone
messages: sarcolemma

9823:RAMP3
gene id: 9823:RAMP3
uniprot id: Q7YS88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAMP family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP3. Interacts with GPER1.
messages: Membrane
messages: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity).

9823:HNF1A
gene id: 9823:HNF1A
uniprot id: A0A8D0KLB7
uniprot id: Q4PJJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9823:SRC
gene id: 9823:SRC
uniprot id: A0A8D0TWL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:PPARA
gene id: 9823:PPARA
uniprot id: Q1W4T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
messages: Nucleus

9823:MRAP2
gene id: 9823:MRAP2
uniprot id: A0A287A4A0
uniprot id: A0A8D2C8J7
uniprot id: I3LK27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC100512703
gene id: 9823:LOC100512703
uniprot id: A0A8D0RIL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:DNM1
gene id: 9823:DNM1
uniprot id: A0A480PE62
uniprot id: A0A8D1AG06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

9823:LOC100519009
gene id: 9823:LOC100519009
uniprot id: A0A5G2QUV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SEPT9
gene id: 9823:SEPT9
uniprot id: A0A8D0SDN0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9823:ECHS1
gene id: 9823:ECHS1
uniprot id: A0A480JRE1
uniprot id: A0A4X1V758
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9823:ADK
gene id: 9823:ADK
uniprot id: A0A287ASQ2
uniprot id: A0A4X1SPA3
uniprot id: A0A4X1SPB8
uniprot id: A0A5G2R0F5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9823:LOC100514912
gene id: 9823:LOC100514912
uniprot id: A0A4X1TZT2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9823:AVPR1B
gene id: 9823:AVPR1B
uniprot id: A0A4X1USR6
uniprot id: F1SF06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9823:NXT2
gene id: 9823:NXT2
uniprot id: A0A4X1W4F7
uniprot id: K7GNP4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9823:LOC100525679
gene id: 9823:LOC100525679
uniprot id: A0A4X1VIM4
uniprot id: K7GP63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9823:COPS4
gene id: 9823:COPS4
uniprot id: A0A4X1TKU2
uniprot id: A0A5G2RKS0
uniprot id: A7Y521
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN4 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
messages: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (By similarity). In the complex, it probably interacts directly with COPS1, COPS2, COPS3, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8 (By similarity). Interacts with TOR1A; the interaction is direct and associates TOR1A and SNAPIN with the CSN complex (By similarity). Interacts with STON2; controls STON2 neddylation levels (By similarity). Interacts with ERCC6 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9823:INPP4A
gene id: 9823:INPP4A
uniprot id: B8R0Y5
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9823:POLR3GL
gene id: 9823:POLR3GL
uniprot id: A0A4X1SJZ4
uniprot id: F1SDF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9823:ITPK1
gene id: 9823:ITPK1
uniprot id: A0A8D0ZQ38
uniprot id: B8XSJ6
names: Similarity
messages: Belongs to the ITPK1 family.

9823:MAGED1
gene id: 9823:MAGED1
uniprot id: Q6ITT4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA (By similarity).
messages: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed (By similarity).
messages: Nucleus

9823:DNAJC5B
gene id: 9823:DNAJC5B
uniprot id: F1RTY8
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with the chaperone complex consisting of HSC70 and SGTA.
messages: Membrane
messages: Palmitoylated.

9823:SH3GL1
gene id: 9823:SH3GL1
uniprot id: A0A4X1VR96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
messages: Membrane

9823:SERPINI1
gene id: 9823:SERPINI1
uniprot id: A0A8D1GMY7
uniprot id: F1SH33
names: Similarity
messages: Belongs to the serpin family.

9823:PUS3
gene id: 9823:PUS3
uniprot id: A0A4X1VF63
uniprot id: F1S759
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9823:RPRD1B
gene id: 9823:RPRD1B
uniprot id: A0A4X1TKC4
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9823:BLM
gene id: 9823:BLM
uniprot id: B0M1M9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9823:ADSL
gene id: 9823:ADSL
uniprot id: A0A4X1W0L6
uniprot id: B3VMQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

9823:PPIL1
gene id: 9823:PPIL1
uniprot id: A0A287AFF5
uniprot id: A0A4X1STN7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9823:SCGB1C1
gene id: 9823:SCGB1C1
uniprot id: A0A4X1SE94
uniprot id: F1RGZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9823:GABRR2
gene id: 9823:GABRR2
uniprot id: A0A4X1VL16
uniprot id: I3LKA9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:TMEM144
gene id: 9823:TMEM144
uniprot id: A0A8D1GQT9
uniprot id: F1RW92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9823:LPIN2
gene id: 9823:LPIN2
uniprot id: B6VE05
names: Similarity
messages: Belongs to the lipin family.

9823:GIPC2
gene id: 9823:GIPC2
uniprot id: A0A287BNZ1
uniprot id: A0A4X1UUE4
names: Similarity
messages: Belongs to the GIPC family.

9823:MRPL20
gene id: 9823:MRPL20
uniprot id: A0A286ZU56
uniprot id: A0A4X1W3A3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9823:SLC41A2
gene id: 9823:SLC41A2
uniprot id: A0A4X1TA14
uniprot id: M3VHB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9823:GMPR
gene id: 9823:GMPR
uniprot id: A0A480PNH9
uniprot id: A0A4X1VN97
uniprot id: A0A4X1VQX6
uniprot id: A0A5G2R384
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ABHD1
gene id: 9823:ABHD1
uniprot id: A0A8D1B060
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9823:POFUT1
gene id: 9823:POFUT1
uniprot id: A0A4X1SUQ0
uniprot id: Q00P49
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

9823:LOC100523622
gene id: 9823:LOC100523622
uniprot id: A0A4X1TJ40
uniprot id: F1S7F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TMEM189
gene id: 9823:TMEM189
uniprot id: A0A4X1UGG4
uniprot id: I3LRW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9823:PTEN
gene id: 9823:PTEN
uniprot id: B8XSI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
messages: Belongs to the PTEN phosphatase protein family.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

9823:OGN
gene id: 9823:OGN
uniprot id: A0A0H5ANC0
uniprot id: A0A4X1TYW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

9823:EAF1
gene id: 9823:EAF1
uniprot id: A0A8D2A0Z8
uniprot id: I3L9Q7
names: Similarity
messages: Belongs to the EAF family.

9823:LOC100738212
gene id: 9823:LOC100738212
uniprot id: A0A4X1V7H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ODF1
gene id: 9823:ODF1
uniprot id: F2Y3N8
uniprot id: Q29077
names: Domain
names: Function
names: Subunit
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.
messages: Interacts (via leucine zipper motif) with TCP11 (By similarity). Interacts with SPAG4 (By similarity). Interacts with KLC3 (By similarity).
messages: The C-terminal contains many C-X-P repeats.

9823:SPRY2
gene id: 9823:SPRY2
uniprot id: A0A4X1V142
uniprot id: F1RP67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: ruffle membrane

9823:MS4A7
gene id: 9823:MS4A7
uniprot id: A0A4X1VMK5
uniprot id: F1RIC4
names: Similarity
messages: Belongs to the MS4A family.

9823:PLPPR3
gene id: 9823:PLPPR3
uniprot id: A0A287BF79
uniprot id: A0A8D1FPF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9823:HGFAC
gene id: 9823:HGFAC
uniprot id: A0A480QPG5
uniprot id: A0A8D1CH00
uniprot id: A0A8D1FZI2
uniprot id: F1S8N1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LAMTOR4
gene id: 9823:LAMTOR4
uniprot id: A0A8D0HMM5
names: Similarity
messages: Belongs to the LAMTOR4 family.

9823:TFAP2D
gene id: 9823:TFAP2D
uniprot id: A0A4X1V0Q4
uniprot id: F1RKV4
names: Similarity
messages: Belongs to the AP-2 family.

9823:GPM6B
gene id: 9823:GPM6B
uniprot id: A0A4X1UQC2
uniprot id: A0A4X1UV67
uniprot id: A0A8D1UT30
uniprot id: A0A8D1Y7W3
uniprot id: F1SRH8
uniprot id: K7GLP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9823:FZD6
gene id: 9823:FZD6
uniprot id: A0A076V355
uniprot id: A0A8D1IU42
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:INSM2
gene id: 9823:INSM2
uniprot id: A0A8D1D3X8
names: Subcellular Location Annotation
messages: Nucleus

9823:RBP1
gene id: 9823:RBP1
uniprot id: A0A8D1YU42
uniprot id: F1SL52
uniprot id: Q53J08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9823:PAQR7
gene id: 9823:PAQR7
uniprot id: Q865K8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Cell membrane
messages: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
messages: Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone.

9823:LOC100156775
gene id: 9823:LOC100156775
uniprot id: A0A4X1UG75
uniprot id: F1RXB6
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100516627
gene id: 9823:LOC100516627
uniprot id: A0A4X1UZH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:STMN4
gene id: 9823:STMN4
uniprot id: A0A287AC62
uniprot id: A0A4X1VCH4
uniprot id: A0A8D1U3I7
uniprot id: I3LL73
names: Similarity
messages: Belongs to the stathmin family.

9823:NOL6
gene id: 9823:NOL6
uniprot id: A0A4X1UR70
uniprot id: F1SE91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

9823:PSMC5
gene id: 9823:PSMC5
uniprot id: A0A287AVG1
uniprot id: A0A480LAT1
uniprot id: A0A480W4X5
uniprot id: A0A4X1T160
uniprot id: A0A8D0S303
uniprot id: P62197
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex (By similarity). The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (By similarity). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components (By similarity). Component of a complex with USP49 and RUVBL1 (By similarity). Interacts with PRPF19 (By similarity). Interacts with TRIM5 (By similarity). Interacts with NDC80 (By similarity). Interacts with PAAF1 (By similarity). Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR) (By similarity). Interacts with ERCC6 (By similarity).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm
messages: Nucleus

9823:LOC110255212
gene id: 9823:LOC110255212
uniprot id: A0A287B1Z6
uniprot id: A0A8D1L7C0
names: Subcellular Location Annotation
messages: Nucleus

9823:ATP4B
gene id: 9823:ATP4B
uniprot id: P18434
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: N-glycosylation is necessary for assembly and functional expression of the pump at the plasma membrane.
messages: Parietal cell autoantigen associated with autoimmune gastritis.
messages: Stomach.
messages: The ATPase pump is composed of two subunits: alpha (catalytic) and beta (regulatory). Interacts with alpha subunit ATP12A; this interaction is required for the formation of a functionally active pump and targeting at the plasma membrane (By similarity). Interacts (via N-terminus) with alpha subunit ATP4A (via the P-domain) (PubMed:19387495, PubMed:29618813).
messages: The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
messages: The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (PubMed:29618813, PubMed:19387495).

9823:RNF167
gene id: 9823:RNF167
uniprot id: A0A4X1UXR8
uniprot id: F1RFY0
names: Subcellular Location Annotation
messages: Membrane

9823:PCCB
gene id: 9823:PCCB
uniprot id: P79384
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AccD/PCCB family.
messages: Mitochondrion matrix
messages: The beta subunit contains the carboxyl transferase (CT) domain.
messages: The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.
messages: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:13752080). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:13752080). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:13752080). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (PubMed:13752080).

9823:TWF1
gene id: 9823:TWF1
uniprot id: A0A8D1TW92
uniprot id: F1SGZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9823:LOC100626271
gene id: 9823:LOC100626271
uniprot id: A0A4X1TGI6
uniprot id: I3LR48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CHFR
gene id: 9823:CHFR
uniprot id: A0A286ZZU2
uniprot id: A0A8D0WIN6
uniprot id: A0A8D0ZK93
uniprot id: F1RI73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHFR family.
messages: PML body

9823:EMC4
gene id: 9823:EMC4
uniprot id: A0A286ZIA2
uniprot id: A0A4X1UNA4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:REC8
gene id: 9823:REC8
uniprot id: F1SGN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9823:CHMP4C
gene id: 9823:CHMP4C
uniprot id: A0A4X1TDZ8
uniprot id: I3LG19
names: Similarity
messages: Belongs to the SNF7 family.

9823:OGFOD1
gene id: 9823:OGFOD1
uniprot id: A0A480KCY2
uniprot id: A0A4X1UD43
names: Similarity
messages: Belongs to the TPA1 family.

9823:MAPKAPK2
gene id: 9823:MAPKAPK2
uniprot id: A0A4X1US57
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:SLC30A1
gene id: 9823:SLC30A1
uniprot id: A0A4X1TIE8
uniprot id: B6VCB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9823:LOC100524268
gene id: 9823:LOC100524268
uniprot id: A0A4X1VH47
uniprot id: F1S7B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RANBP6
gene id: 9823:RANBP6
uniprot id: A0A4X1W874
uniprot id: A0A5G2R634
names: Subcellular Location Annotation
messages: Cytoplasm

9823:NAMPT
gene id: 9823:NAMPT
uniprot id: A8HR17
uniprot id: Q52I78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

9823:CA11
gene id: 9823:CA11
uniprot id: A0A480JGT2
uniprot id: A0A4X1W0M0
uniprot id: Q866X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.
messages: Secreted

9823:SMDT1
gene id: 9823:SMDT1
uniprot id: A0A4X1W3P7
uniprot id: F1SJP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9823:LOC100620101
gene id: 9823:LOC100620101
uniprot id: A0A286ZQT8
uniprot id: A0A8D2C9K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TSPAN5
gene id: 9823:TSPAN5
uniprot id: A0A4X1UED4
uniprot id: I3LPC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:RGS1
gene id: 9823:RGS1
uniprot id: A0A286ZKX9
uniprot id: A0A4X1TVW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

9823:PGA5
gene id: 9823:PGA5
uniprot id: A1YM35
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:PMF1
gene id: 9823:PMF1
uniprot id: A0A4X1VTK7
uniprot id: F1RLQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Nucleus
messages: kinetochore

9823:VANGL1
gene id: 9823:VANGL1
uniprot id: A0A4X1SXH9
uniprot id: F1SAW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9823:EXOSC9
gene id: 9823:EXOSC9
uniprot id: A0A480UK42
uniprot id: A0A8D0KB04
names: Subcellular Location Annotation
messages: Cytoplasm

9823:NDUFA2
gene id: 9823:NDUFA2
uniprot id: A0A8D1FN21
uniprot id: F1RGE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:TIPIN
gene id: 9823:TIPIN
uniprot id: A0A4X1TE12
uniprot id: F1SJJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9823:MGAT4C
gene id: 9823:MGAT4C
uniprot id: Q6ITT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity).
messages: Golgi apparatus membrane

9823:MAN2C1
gene id: 9823:MAN2C1
uniprot id: A0A287AZU8
uniprot id: A0A4X1TU50
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

9823:JAK1
gene id: 9823:JAK1
uniprot id: Q9TTJ1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9823:MSTN
gene id: 9823:MSTN
uniprot id: Q6SVB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted

9823:RAB9A
gene id: 9823:RAB9A
uniprot id: A0A8D1R2H7
uniprot id: F1SRI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9823:RDH11
gene id: 9823:RDH11
uniprot id: A0A8D1YEA1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:SLC25A33
gene id: 9823:SLC25A33
uniprot id: A0A287BLT7
uniprot id: A0A4X1W7Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:GCG
gene id: 9823:GCG
uniprot id: P01274
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glucagon family.
messages: GLP-2 does not have cleavage on a pair of basic residues at C-terminus as in other mammals.
messages: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain.
messages: Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion (By similarity).
messages: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
messages: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
messages: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.
messages: Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas (By similarity).
messages: Secreted
messages: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.
messages: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.

9823:PPIC
gene id: 9823:PPIC
uniprot id: A0A287AEA2
uniprot id: A0A4X1UDH8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9823:ARRB1
gene id: 9823:ARRB1
uniprot id: A0A286ZND1
uniprot id: A0A286ZZD7
uniprot id: A0A480TT90
uniprot id: A0A8D0N667
uniprot id: A0A8D0S8Q0
uniprot id: A0A8D1RNJ6
names: Similarity
messages: Belongs to the arrestin family.

9823:ZSCAN16
gene id: 9823:ZSCAN16
uniprot id: A0A4X1VM37
names: Subcellular Location Annotation
messages: Nucleus

9823:LETM2
gene id: 9823:LETM2
uniprot id: A0A286ZWP2
uniprot id: A0A287AEL5
uniprot id: A0A8D0ZIV6
names: Subcellular Location Annotation
messages: Membrane

9823:FGF20
gene id: 9823:FGF20
uniprot id: A0A4X1TU89
uniprot id: G0ZMB9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9823:SLC25A44
gene id: 9823:SLC25A44
uniprot id: A0A4X1VZF2
uniprot id: F1RLQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:CNNM2
gene id: 9823:CNNM2
uniprot id: A0A287AM25
uniprot id: A0A8D0VJ22
uniprot id: A0A8D1I237
uniprot id: F1S849
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9823:EMSY
gene id: 9823:EMSY
uniprot id: A0A287AIH4
uniprot id: A0A480EY27
uniprot id: A0A480WC73
uniprot id: A0A4X1UEX7
uniprot id: A0A4X1UKE9
uniprot id: A0A8D0IDZ4
names: Subcellular Location Annotation
messages: Nucleus

9823:ZNF408
gene id: 9823:ZNF408
uniprot id: A0A8D1RQ43
names: Subcellular Location Annotation
messages: Nucleus

9823:SGCZ
gene id: 9823:SGCZ
uniprot id: B8YDG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9823:SIAH2
gene id: 9823:SIAH2
uniprot id: A0A287ASV6
uniprot id: A0A4X1SW38
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9823:LOC100516933
gene id: 9823:LOC100516933
uniprot id: F1RRP5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ALG3
gene id: 9823:ALG3
uniprot id: A0A480M700
uniprot id: A0A4X1UMX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:CLDN4
gene id: 9823:CLDN4
uniprot id: A0A4X1UKW6
uniprot id: C3VML0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:STX16
gene id: 9823:STX16
uniprot id: A0A4X1UST5
uniprot id: A0A4X1UTY6
uniprot id: A0A8D0UWQ6
uniprot id: A0A8D1E861
uniprot id: A0A8D2BLI7
uniprot id: A5GFS9
uniprot id: A5GFT0
uniprot id: A5GFT1
uniprot id: A5GFT2
names: Similarity
messages: Belongs to the syntaxin family.

9823:CRISP1
gene id: 9823:CRISP1
uniprot id: A0A8D0S0L0
uniprot id: B2ZGN1
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:HOXD1
gene id: 9823:HOXD1
uniprot id: A0A4X1UH02
uniprot id: F1RZF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9823:BAALC
gene id: 9823:BAALC
uniprot id: Q8WNE9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in the brain.
messages: Interacts with CAMK2A.
messages: May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A.
messages: Membrane raft
messages: Palmitoylation and myristoylation target the protein to the lipid rafts.
messages: Postsynaptic density
messages: synaptosome

9823:ARHGDIB
gene id: 9823:ARHGDIB
uniprot id: A0A287B0I3
uniprot id: A0A4X1V4G4
names: Similarity
messages: Belongs to the Rho GDI family.

9823:TSC22D2
gene id: 9823:TSC22D2
uniprot id: A0A8D0YQX8
uniprot id: A0A8D1WHD1
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9823:PSAPL1
gene id: 9823:PSAPL1
uniprot id: F1S8K7
names: Subcellular Location Annotation
messages: Secreted

9823:PAPPA2
gene id: 9823:PAPPA2
uniprot id: A0A4X1U6X1
uniprot id: F1S703
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:KLHL3
gene id: 9823:KLHL3
uniprot id: A0A287AFL0
uniprot id: A0A4X1V568
uniprot id: A0A8D1IG49
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

9823:TSEN15
gene id: 9823:TSEN15
uniprot id: A0A8D1X8K8
names: Similarity
messages: Belongs to the SEN15 family.

9823:MTOR
gene id: 9823:MTOR
uniprot id: A0A4X1W882
uniprot id: F1RHR8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9823:MED28
gene id: 9823:MED28
uniprot id: A0A480PTL8
uniprot id: A0A4X1VBW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9823:GCK
gene id: 9823:GCK
uniprot id: A0A4X1UII0
uniprot id: A0A8D1L8T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9823:RPL11
gene id: 9823:RPL11
uniprot id: Q29205
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11. Interacts with PML. Interacts with MDM2; negatively regulates MDM2-mediated TP53 ubiquitination and degradation. Interacts with NOP53; retains RPL11 into the nucleolus.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML.
messages: Cytoplasm
messages: nucleolus

9823:OST4
gene id: 9823:OST4
uniprot id: A0A4X1TTR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:STAC2
gene id: 9823:STAC2
uniprot id: A0A480MPY7
uniprot id: A0A4X1UHE5
uniprot id: A0A8D1BK21
uniprot id: F1RWK9
names: Subcellular Location Annotation
messages: sarcolemma

9823:LOC100521249
gene id: 9823:LOC100521249
uniprot id: A0A287B655
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ADM5
gene id: 9823:ADM5
uniprot id: A5LHG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adrenomedullin family.
messages: Expressed abundantly in the spleen and thymus. Also expressed in adrenal and pituitary. Not expressed in brain, heart, kidney, liver and stomach.
messages: Secreted
messages: Seems to have a peripheral vasodepressor effect and a central vasopressor effect.

9823:RETREG3
gene id: 9823:RETREG3
uniprot id: A0A287BPH4
uniprot id: A0A4X1U0B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9823:SPERT
gene id: 9823:SPERT
uniprot id: A0A8D1J8M4
names: Similarity
names: Subunit
messages: Belongs to the chibby family. SPERT subfamily.
messages: Homodimer. Binds to NEK1.

9823:MAEL
gene id: 9823:MAEL
uniprot id: A4UTQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the maelstrom family.
messages: Cytoplasm
messages: Interacts with SMARCB1, SIN3B and DDX4. Interacts with piRNA-associated proteins TDRD1, PIWIL1 and PIWIL2 (By similarity). Interacts with TEX19 (By similarity).
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).

9823:HMGN2
gene id: 9823:HMGN2
uniprot id: P80272
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylation favors cytoplasmic localization.

9823:EPHB4
gene id: 9823:EPHB4
uniprot id: A0A4X1UDQ7
names: Subcellular Location Annotation
messages: Membrane

9823:VTI1B
gene id: 9823:VTI1B
uniprot id: Q6R6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9823:PDE6H
gene id: 9823:PDE6H
uniprot id: A0A287AXH0
uniprot id: A0A4X1V4G8
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9823:THRB
gene id: 9823:THRB
uniprot id: A0A286ZWA8
uniprot id: A0A287A833
uniprot id: A0A4X1UK31
uniprot id: A0A4X1ULP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:ACTRT3
gene id: 9823:ACTRT3
uniprot id: A0A287BMQ2
uniprot id: A0A4X1VEG6
names: Similarity
messages: Belongs to the actin family.

9823:TRMT5
gene id: 9823:TRMT5
uniprot id: A0A4X1W7D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

9823:LOC100153886
gene id: 9823:LOC100153886
uniprot id: A0A4X1UQL3
uniprot id: K7GPC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SPAM1
gene id: 9823:SPAM1
uniprot id: A0A8D0LDY4
uniprot id: Q8MI02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9823:LOC100152306
gene id: 9823:LOC100152306
uniprot id: A0A480SJC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9823:BAZ2A
gene id: 9823:BAZ2A
uniprot id: A0A8D1UGV6
names: Similarity
messages: Belongs to the WAL family.

9823:EXOSC1
gene id: 9823:EXOSC1
uniprot id: A0A4X1UA33
uniprot id: F1S8Y4
names: Subcellular Location Annotation
messages: Cytoplasm

9823:TGFB1
gene id: 9823:TGFB1
uniprot id: P07200
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction.
messages: Homodimer; disulfide-linked. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling and the HTRA protease activity is required for this inhibition. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with CD109, DPT and ASPN. Interacts with EFEMP2. Interacts with TSKU; the interaction contributes to regulation of the hair cycle.
messages: Homodimer; disulfide-linked. Interacts with transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains TGF-beta-1 in a latent state; each latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Interacts with LTBP1; leading to regulation of TGF-beta-1 activation. Interacts with LRRC32/GARP; leading to regulation of TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Interacts with LRRC33/NRROS; leading to regulation of TGF-beta-1 activation in macrophages and microglia. Interacts (via cell attachment site) with integrins ITGAV and ITGB6 (ITGAV:ITGB6), leading to release of the active TGF-beta-1. Interacts with NREP; the interaction results in a decrease in TGFB1 autoinduction. Interacts with HSP90AB1; inhibits latent TGFB1 activation.
messages: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'. Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 ce…
messages: N-glycosylated. Deglycosylation leads to activation of Transforming growth factor beta-1 (TGF-beta-1); mechanisms triggering deglycosylation-driven activation of TGF-beta-1 are however unclear.
messages: PubMed:3166520 sequence which was said to originate from chicken. It however seems to originate from pig.
messages: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.
messages: Secreted
messages: The 'straitjacket' and 'arm' domains encircle the Transforming growth factor beta-1 (TGF-beta-1) monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104.
messages: The cell attachment site motif mediates binding to integrins (ITGAV:ITGB6 or ITGAV:ITGB8). The motif locates to a long loop in the arm domain called the bowtie tail. Integrin-binding stabilizes an alternative conformation of the bowtie tail (PubMed:21677751). Activation by integrin requires force application by the actin cytoskeleton, which is resisted by the 'milieu molecules' (such as LTBP1, LRRC32/GARP and/or LRRC33/NRROS), resulting in distortion of the prodomain and release of the active TGF-beta-1 (By similarity).
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
messages: extracellular matrix

9823:LOC100519675
gene id: 9823:LOC100519675
uniprot id: A0A286ZLH8
uniprot id: A0A4X1TPT1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9823:CCT4
gene id: 9823:CCT4
uniprot id: A0A4X1WBL9
uniprot id: F1SQN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9823:LOC100518620
gene id: 9823:LOC100518620
uniprot id: A0A287A0X1
uniprot id: A0A4X1UUS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9823:GRK4
gene id: 9823:GRK4
uniprot id: A0A8D1PZE3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9823:SLC13A2
gene id: 9823:SLC13A2
uniprot id: A0A480QMV3
uniprot id: A0A4X1TMC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9823:CAV1
gene id: 9823:CAV1
uniprot id: Q6RVA9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: Membrane raft
messages: Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.
messages: caveola

9823:VBP1
gene id: 9823:VBP1
uniprot id: A0A4X1T8E4
uniprot id: A0A5G2QNT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9823:ARG2
gene id: 9823:ARG2
uniprot id: A0A4X1U8K8
uniprot id: A0A8D0Z0W9
uniprot id: F1SA26
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9823:FUNDC1
gene id: 9823:FUNDC1
uniprot id: A0A4X1VJB8
uniprot id: F1RWZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9823:SMARCB1
gene id: 9823:SMARCB1
uniprot id: A0A287A179
uniprot id: A0A4X1V165
uniprot id: A0A4X1V171
uniprot id: F2Z4X9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

9823:NR2C2
gene id: 9823:NR2C2
uniprot id: A0A480QDE3
uniprot id: A0A4X1U9D4
uniprot id: A0A4X1UBA4
uniprot id: F1SPJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:KCNMA1
gene id: 9823:KCNMA1
uniprot id: O18866
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Cell membrane
messages: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation (By similarity).
messages: Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity. Interacts with RAB11B (By similarity).
messages: Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network (By similarity).
messages: Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity (By similarity).
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity).
messages: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).
messages: The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4.
messages: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensors regions required for activation of the channel (By similarity).
messages: The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation (By similarity).
messages: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).
messages: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca(2+) and Mg(2+).

9823:RENBP
gene id: 9823:RENBP
uniprot id: A0A480X7B8
uniprot id: P17560
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Activity of the enzyme is enhanced about 20-fold in the presence of ATP.
messages: Belongs to the N-acylglucosamine 2-epimerase family.
messages: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:8663114). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity).
messages: Homodimer (PubMed:8663114, PubMed:2050686, PubMed:11061972). Forms a heterodimer with renin and inhibits its activity (PubMed:2182620, PubMed:8663114, PubMed:2050686, PubMed:11061972).
messages: Kidney, liver, adrenal, and pituitary glands the amount being much greater in kidney than in the other tissues.

9823:SELENOF
gene id: 9823:SELENOF
uniprot id: A1Z623
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenoprotein M/F family.
messages: Endoplasmic reticulum lumen
messages: Forms a tight complex with UGGT1/UGCGL1. Interacts with UGGT2/UGCGL2. Interacts with RDH11.
messages: May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity).

9823:TMEM216
gene id: 9823:TMEM216
uniprot id: A0A287AG87
uniprot id: A0A4X1VP00
uniprot id: A0A8D1UQI1
uniprot id: F1RKQ7
names: Subcellular Location Annotation
messages: Membrane

9823:PEX14
gene id: 9823:PEX14
uniprot id: F1RHS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

9823:ADRB2
gene id: 9823:ADRB2
uniprot id: Q28997
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity).
messages: Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (By similarity). Interacts with USP20 and USP33 (By similarity). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4 (By similarity). Interacts with MARCHF2 (By similarity).
messages: Cell membrane
messages: Early endosome
messages: Expressed in heart, liver, lung, skeletal muscle and subcutaneous adipose tissue.
messages: Golgi apparatus
messages: Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
messages: Palmitoylated. Mainly palmitoylated at Cys-341. Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi. Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor. Could be depalmitoylated by LYPLA1 at the plasma membrane.
messages: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity).
messages: Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
messages: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
messages: Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity).

9823:KIF1BP
gene id: 9823:KIF1BP
uniprot id: A0A4X1TLJ5
uniprot id: F1SUG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

9823:TMPO
gene id: 9823:TMPO
uniprot id: A0A8D1CS34
names: Similarity
messages: Belongs to the LEM family.

9823:SMAD4
gene id: 9823:SMAD4
uniprot id: A0A480EJV2
uniprot id: Q9GKQ9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dwarfin/SMAD family.
messages: Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity).
messages: Cytoplasm
messages: Monomer; in the absence of TGF-beta activation (By similarity). Heterotrimer; on TGF-beta activation (By similarity). Heterotrimer composed of two molecules of a C-terminally phosphorylated R-SMAD molecule, SMAD2 or SMAD3, and one molecule of SMAD4 to form the transcriptional active SMAD2/SMAD3-SMAD4 complex (By similarity). Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Found in a complex with SMAD1 and YY1. Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4. Interacts with ATF2, COPS5, DACH1, MSG1, SKI, STK11/LKB1, STK11IP and TRIM33. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with USP9X. Interacts with RBPMS. Interacts with WWTR1 (via coiled-coil domain). Interacts with CITED1 and CITED2. Interacts with PDPK1 (via PH domain). Interacts with VPS39; this interaction affects heterodimer formation with SMAD3, but not with SMAD2, and leads to inhibition of SMAD3-dependent transcription activation. Interactions with VPS39 and SMAD2 may be mutually exclusive. Interacts (via MH2 domain) with ZNF451 (via N-terminal zinc-finger domains) (By similarity). Interacts with ZC3H3. Interacts weakly with ZNF8. Interacts with NUP93 and IPO7; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling (By similarity). Interacts with CREB3L1, the interaction takes place upon TGFB1 induction and SMAD4 acts as CREB3L1 coactivator to induce the expression of genes involved in the assembly of collagen extracellular matrix (By similarity). Interacts with DLX1 (By similarity). Interacts with ZBTB7A; the interaction is direct and stimulated by TGFB1 (By similarity). Interacts with CREBBP; the recruitment of this transcriptional coactivator is negatively regulated by ZBTB7A (By similarity). Interacts with EP300; the interaction with this transcriptional coactivator is negatively regulated by ZBTB7A (By similarity).…
messages: Monoubiquitinated on Lys-519 by E3 ubiquitin-protein ligase TRIM33. Monoubiquitination hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination by USP9X restores its competence to mediate TGF-beta signaling (By similarity).
messages: Nucleus
messages: Phosphorylated by PDPK1.
messages: The MH1 domain is required for DNA binding.
messages: The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import (By similarity).

9823:CTLA4
gene id: 9823:CTLA4
uniprot id: Q9N186
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9823:QDPR
gene id: 9823:QDPR
uniprot id: Q8MJ30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
messages: Homodimer.

9823:TRAF6
gene id: 9823:TRAF6
uniprot id: A7XUJ6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Cytoplasm
messages: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN (By similarity). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Participates also in the TCR signaling by ubiquitinating LAT (By similarity).
messages: Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK2, IRAK3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI2 and PELI3. Binds UBE2V1. Interacts with TAX1BP1; this interaction mediates deubiquitination of TRAF6 and inhibition of NF-kappa-B activation (By similarity). Interacts with ZNF675. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts with RBCK1. Interacts with LIMD1 (via LIM domains) (By similarity). Interacts with RSAD2/viperin (By similarity). Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity). Interacts with ZFAND5. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with AJUBA. Interacts with MAVS/IPS1. Interacts (via TRAF domains) with DYNC2I2 (via WD domains). Interacts with IFIT3 (via N-terminus). Interacts with TICAM2. Interacts with CARD14. Interacts with CD40 and MAP3K8; the interaction is required for ERK activation (By similarity). Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1. Interacts with TANK; this interaction increases in response to DNA damage. Interacts with USP…
messages: Lipid droplet
messages: Nucleus
messages: Polyubiquitinated on Lys-125 by TRAF3IP2; after cell stimulation with IL17A (By similarity). Polyubiquitinated; after cell stimulation with IL1B or TGFB. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage. LRRC19 induces 'Lys-63' ubiquitination (By similarity).
messages: Sumoylated on Lys-125, Lys-143 and Lys-472 with SUMO1.
messages: The MATH/TRAF domain binds to receptor cytoplasmic domains.
messages: The coiled coil domain mediates homo- and hetero-oligomerization.
messages: cell cortex

9823:PPP1R15A
gene id: 9823:PPP1R15A
uniprot id: A0A8D1S8R8
names: Similarity
messages: Belongs to the PPP1R15 family.

9823:TIMM8A
gene id: 9823:TIMM8A
uniprot id: A0A4X1W4Y0
uniprot id: F1S1L1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9823:LOC100519808
gene id: 9823:LOC100519808
uniprot id: A0A287AH66
uniprot id: A0A287APH1
uniprot id: A0A4X1UVM9
uniprot id: A0A8D1G401
names: Similarity
messages: Belongs to the TCAF family.

9823:P4HA1
gene id: 9823:P4HA1
uniprot id: A0A286ZUW5
uniprot id: A0A4X1T5S7
uniprot id: A0A4X1T726
uniprot id: A1X898
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9823:AQP1
gene id: 9823:AQP1
uniprot id: Q6PQZ1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
messages: Homotetramer (By similarity). Interacts with EPHB2; involved in endolymph production in the inner ear. Identified in a complex with STOM (By similarity).
messages: Pharmacologically inhibited by submillimolar concentrations of mercury.

9823:ERLIN2
gene id: 9823:ERLIN2
uniprot id: A0A287BPU3
uniprot id: A0A287BRP6
uniprot id: A0A4X1VV43
uniprot id: A0A4X1VVT9
uniprot id: B8XSJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9823:MMP12
gene id: 9823:MMP12
uniprot id: A6H560
names: Similarity
messages: Belongs to the peptidase M10A family.

9823:MTMR11
gene id: 9823:MTMR11
uniprot id: A0A480EMZ5
uniprot id: A0A4X1SIR9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9823:ARCN1
gene id: 9823:ARCN1
uniprot id: A0A4X1SPY8
uniprot id: I3LBY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9823:JAKMIP3
gene id: 9823:JAKMIP3
uniprot id: A0A287BG61
names: Similarity
messages: Belongs to the JAKMIP family.

9823:CTNNAL1
gene id: 9823:CTNNAL1
uniprot id: A0A4X1VC34
uniprot id: F1SP25
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9823:NIPAL3
gene id: 9823:NIPAL3
uniprot id: A0A4X1VVR2
uniprot id: A0A8D0R5P6
uniprot id: F1STV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9823:CIRBP
gene id: 9823:CIRBP
uniprot id: A0A287A085
uniprot id: A0A287AK75
uniprot id: A0A4X1VTK6
uniprot id: A0A4X1VVR9
uniprot id: A0A8D0QMV5
uniprot id: F1S6R1
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

9823:SLC30A2
gene id: 9823:SLC30A2
uniprot id: A0A8D1BD66
uniprot id: B5A8K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9823:ZNF165
gene id: 9823:ZNF165
uniprot id: A0A481AL25
uniprot id: A0A4X1VJD3
names: Subcellular Location Annotation
messages: Nucleus

9823:VRTN
gene id: 9823:VRTN
uniprot id: E1CHH8
names: Similarity
messages: Belongs to the vertnin family.

9823:CXHXorf23
gene id: 9823:CXHXorf23
uniprot id: A0A480NUY6
uniprot id: A0A4X1V7P7
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9823:PLIN2
gene id: 9823:PLIN2
uniprot id: A0A287AAY1
uniprot id: A0A4X1WBQ4
uniprot id: A0A4X1WCX4
uniprot id: D0G0B6
uniprot id: Q9MZE5
names: Similarity
messages: Belongs to the perilipin family.

9823:BUD31
gene id: 9823:BUD31
uniprot id: A0A4X1U3H4
uniprot id: K7N7E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9823:ATG4C
gene id: 9823:ATG4C
uniprot id: A0A287BLN8
uniprot id: A0A4X1T8S6
uniprot id: D7RA23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9823:VAMP7
gene id: 9823:VAMP7
uniprot id: A0A4X1TWS7
uniprot id: I3LN62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9823:PIK3CD
gene id: 9823:PIK3CD
uniprot id: A0A5K1UPW2
uniprot id: A0A8D0WQF3
uniprot id: A0A8D1VQB8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9823:GNB5
gene id: 9823:GNB5
uniprot id: A0A4X1T5F1
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9823:PLAT
gene id: 9823:PLAT
uniprot id: Q8SQ23
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Both FN1 and EGF-like domains are important for binding to LRP1.
messages: Both FN1 and one of the kringle domains are required for binding to fibrin.
messages: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy.
messages: Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Binds LRP1B; binding is followed by internalization and degradation. Forms heterodimer with SERPINA5 (By similarity). In complex with SERPINE1, interacts with SORL1 (By similarity).
messages: Inhibited by SERPINA5.
messages: The FN1 domain mediates binding to annexin A2.
messages: The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site.
messages: The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.
messages: extracellular space

9823:KIAA1191
gene id: 9823:KIAA1191
uniprot id: A0A480JME6
uniprot id: A0A4X1SLG4
uniprot id: A0A4X1SLI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9823:TYW1
gene id: 9823:TYW1
uniprot id: A0A8D0SSZ8
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

9823:KRT34
gene id: 9823:KRT34
uniprot id: A0A4X1U891
uniprot id: F1S0K4
names: Similarity
messages: Belongs to the intermediate filament family.

9823:ATOH7
gene id: 9823:ATOH7
uniprot id: A0A4X1TLW1
uniprot id: I3LH93
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

9823:PRKCD
gene id: 9823:PRKCD
uniprot id: A0A287B8W9
uniprot id: A0A8D0R7E4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

9823:HIGD1B
gene id: 9823:HIGD1B
uniprot id: A0A480VU00
uniprot id: A0A8D1YFI5
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9823:LRRC14
gene id: 9823:LRRC14
uniprot id: A0A286ZQY7
uniprot id: A0A4X1UPU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRAME family. LRRC14 subfamily.
messages: Cytoplasm

9823:ALDH5A1
gene id: 9823:ALDH5A1
uniprot id: A0A481AID6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

9823:AVPR1A
gene id: 9823:AVPR1A
uniprot id: A0A286ZX01
uniprot id: A0A4X1W2U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9823:SAP30L
gene id: 9823:SAP30L
uniprot id: A0A287ABA7
uniprot id: A0A4X1TTB1
names: Similarity
messages: Belongs to the SAP30 family.

9823:HCFC2
gene id: 9823:HCFC2
uniprot id: A0A4X1T6P9
uniprot id: F1SRK9
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100623024
gene id: 9823:LOC100623024
uniprot id: A0A4X1TXD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:POLR2L
gene id: 9823:POLR2L
uniprot id: A0A4X1VYD0
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

9823:COQ10A
gene id: 9823:COQ10A
uniprot id: A0A8D1P408
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9823:LOC100154892
gene id: 9823:LOC100154892
uniprot id: A0A286ZHX1
uniprot id: A0A4X1V031
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9823:TMED1
gene id: 9823:TMED1
uniprot id: A0A287BCX9
uniprot id: A0A4X1VH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9823:CENPO
gene id: 9823:CENPO
uniprot id: A0A4X1TV58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9823:LOC100512477
gene id: 9823:LOC100512477
uniprot id: A0A4X1SLT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ZC3HAV1
gene id: 9823:ZC3HAV1
uniprot id: A0A287B525
uniprot id: A0A4X1VAZ4
uniprot id: A0A4X1VEP1
uniprot id: D4P3C2
names: Similarity
messages: Belongs to the ARTD/PARP family.

9823:SCML2
gene id: 9823:SCML2
uniprot id: A0A4X1UZZ0
uniprot id: K7GKY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9823:FRK
gene id: 9823:FRK
uniprot id: A0A4X1V6L0
uniprot id: F1RZK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:FGF4
gene id: 9823:FGF4
uniprot id: A0A8D1TD03
uniprot id: F1RY80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

9823:PIK3R5
gene id: 9823:PIK3R5
uniprot id: O02696
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Greatly activated by G gamma proteins.
messages: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.
messages: Nucleus
messages: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.
messages: The heterodimerization region allows the binding to the catalytic subunit.

9823:HUS1
gene id: 9823:HUS1
uniprot id: A0A4X1U7V9
uniprot id: B6UV60
names: Similarity
messages: Belongs to the HUS1 family.

9823:EDNRB
gene id: 9823:EDNRB
uniprot id: P35463
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
messages: Cell membrane
messages: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9823:NAA40
gene id: 9823:NAA40
uniprot id: A0A8D0ZH34
uniprot id: F1RPY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

9823:CRAT
gene id: 9823:CRAT
uniprot id: A0A8D1QS88
uniprot id: A9JPD4
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9823:CNTF
gene id: 9823:CNTF
uniprot id: A0A8D1R2M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9823:FKBP4
gene id: 9823:FKBP4
uniprot id: A0A8D0NS09
uniprot id: D3K5K2
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Nucleus
messages: cytoskeleton
messages: cytosol

9823:NDUFB5
gene id: 9823:NDUFB5
uniprot id: A0A4X1V585
uniprot id: F1SGC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:WNT8B
gene id: 9823:WNT8B
uniprot id: A0A4X1TZ80
uniprot id: F1RWL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:SNX10
gene id: 9823:SNX10
uniprot id: A0A4X1TTL3
uniprot id: F2Z5P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9823:TEC
gene id: 9823:TEC
uniprot id: A0A8D0NHD6
uniprot id: F1SEA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:GNGT1
gene id: 9823:GNGT1
uniprot id: A0A4X1U0G3
uniprot id: F1SFB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9823:ARSE
gene id: 9823:ARSE
uniprot id: A0A4X1TTK6
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9823:TNC
gene id: 9823:TNC
uniprot id: Q29116
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tenascin family.
messages: By TGF-beta.
messages: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).
messages: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 (By similarity).
messages: N-glycosylated.
messages: Predominantly expressed in the embryonic and early postnatal stages. Little or no detection in adult brain.
messages: Submaxillary glands and brain.
messages: extracellular matrix

9823:PLPPR4
gene id: 9823:PLPPR4
uniprot id: A0A8D0YWJ0
uniprot id: F1S553
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9823:TMEM126A
gene id: 9823:TMEM126A
uniprot id: A0A4X1U7Y9
uniprot id: I3LJK4
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100621421
gene id: 9823:LOC100621421
uniprot id: A0A8D0SGP5
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9823:AKT3
gene id: 9823:AKT3
uniprot id: A0A287AN96
uniprot id: A0A287BC23
uniprot id: A0A4X1T4H6
uniprot id: A0A4X1T4I6
uniprot id: A0A4X1T5S8
uniprot id: A0A4X1T5U2
uniprot id: G9BWQ3
uniprot id: K7GLV8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9823:AP2M1
gene id: 9823:AP2M1
uniprot id: A0A8D0WS89
uniprot id: I3LL07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9823:MNX1
gene id: 9823:MNX1
uniprot id: A0A8D0RKP6
names: Subcellular Location Annotation
messages: Nucleus

9823:FADS3
gene id: 9823:FADS3
uniprot id: A0A8D0ZT88
uniprot id: D2D0E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9823:IDH3B
gene id: 9823:IDH3B
uniprot id: A0A8D1ZWC4
uniprot id: Q1G1K7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9823:XK
gene id: 9823:XK
uniprot id: A0A286ZKL8
uniprot id: A0A4X1VJC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9823:BLCAP
gene id: 9823:BLCAP
uniprot id: A0A4X1THT8
names: Similarity
messages: Belongs to the BLCAP family.

9823:ERGIC1
gene id: 9823:ERGIC1
uniprot id: A0A8D1MNR8
uniprot id: F1SJY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9823:TUBB2B
gene id: 9823:TUBB2B
uniprot id: A0A287AGU7
uniprot id: A0A8D1UIR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:MEF2C
gene id: 9823:MEF2C
uniprot id: A0A286ZUG7
uniprot id: A0A8D1ZUQ2
uniprot id: A4UTP7
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity).
messages: Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation (By similarity). Interacts with HDAC7 and CARM1 (By similarity). Interacts with HDAC4, HDAC7 and HDAC9; the interaction with HDACs represses transcriptional activity (By similarity). Interacts with LPIN1. Interacts with MYOCD. Interacts with AKAP13. Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity (By similarity). Interacts (via N-terminus) with HABP4; this interaction decreases DNA-binding activity of MEF2C in myocardial cells in response to mechanical stress (By similarity). Interacts with JPH2; interaction specifically takes place with the Junctophilin-2 N-terminal fragment cleavage product of JPH2 (By similarity). Interacts (via MADS box) with SOX18 (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-59; which enhances DNA binding activity. Phosphorylated on Ser-386; which is required for Lys-381 sumoylation and inhibits transcriptional activity.
messages: Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity).
messages: Sumoylated on Lys-381 with SUMO2 but not SUMO1; which represses transcriptional activity.
messages: The beta domain is required for enhancement of transcriptional activity.
messages: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity).
messages: sarcoplasm

9823:NR0B2
gene id: 9823:NR0B2
uniprot id: A0A8D1XQX8
uniprot id: F1STR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9823:MID1
gene id: 9823:MID1
uniprot id: A0A5G2R4L4
uniprot id: A0A8D0NN50
uniprot id: A0A8D1YVQ6
uniprot id: K7GSV3
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

9823:MAOA
gene id: 9823:MAOA
uniprot id: Q6Q2J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

9823:LOC100522220
gene id: 9823:LOC100522220
uniprot id: A0A8D0UDF0
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9823:ZRANB1
gene id: 9823:ZRANB1
uniprot id: A0A287BI48
uniprot id: A0A4X1VAY5
uniprot id: A0A4X1VBK1
uniprot id: F1SDN8
names: Similarity
messages: Belongs to the peptidase C64 family.

9823:CTC1
gene id: 9823:CTC1
uniprot id: A0A8D1RLP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9823:CRYBB1
gene id: 9823:CRYBB1
uniprot id: Q007T1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).
messages: Specific cleavages in the N-terminal arm occur during lens maturation and give rise to truncated forms, leading to impaired oligomerization and protein insolubilization.

9823:RIC3
gene id: 9823:RIC3
uniprot id: A0A8D0R739
uniprot id: A0A8D1W1N9
names: Similarity
messages: Belongs to the ric-3 family.

9823:NCOA1
gene id: 9823:NCOA1
uniprot id: Q4PJW2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors.
messages: Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with COPS5, NR3C1, PCAF and TTLL5/STAMP. Interacts with the histone acetyltransferases EP300 and CREBBP, and the methyltransferase CARM1. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2 and DDX5. Interacts with ASXL1. Interacts with PRMT6. Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts in a ligand-dependent fashion with RXRA. Interacts with TRIP4. Interacts with NR4A3. Interacts with VDR.
messages: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response (By similarity).
messages: Nucleus
messages: Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein (By similarity).
messages: The C-terminal (1107-1447) part mediates the histone acetyltransferase (HAT) activity.
messages: Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites (By similarity).

9823:KIF22
gene id: 9823:KIF22
uniprot id: A0A4X1TVE1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:SNRPA
gene id: 9823:SNRPA
uniprot id: Q06AA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM U1 A/B'' family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity).
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP-free complex with SFPQ (By similarity).

9823:DDI1
gene id: 9823:DDI1
uniprot id: A0A4X1TMV8
names: Similarity
messages: Belongs to the DDI1 family.

9823:LTA
gene id: 9823:LTA
uniprot id: B9TSQ9
uniprot id: P26445
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9823:ABL2
gene id: 9823:ABL2
uniprot id: A0A286ZN83
uniprot id: A0A287AQK4
uniprot id: A0A4X1U5Y5
uniprot id: A0A4X1U822
uniprot id: A0A4X1U827
uniprot id: A0A4X1U8J1
uniprot id: A0A4X1U8M4
uniprot id: A0A8D1ES88
uniprot id: A0A8D1EUQ4
uniprot id: A0A8D1NF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:ATP5E
gene id: 9823:ATP5E
uniprot id: A0A4X1UTW2
uniprot id: A5GFX4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9823:PON3
gene id: 9823:PON3
uniprot id: A0A4X1TVE8
uniprot id: Q195H3
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9823:MRPS26
gene id: 9823:MRPS26
uniprot id: A0A4X1SEN9
uniprot id: F1S8A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9823:CCT5
gene id: 9823:CCT5
uniprot id: L7PBE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9823:CHST2
gene id: 9823:CHST2
uniprot id: A0A8D1D956
uniprot id: I3L6A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9823:TSSK1B
gene id: 9823:TSSK1B
uniprot id: A0A8D0SR93
uniprot id: F1RK80
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:MYF5
gene id: 9823:MYF5
uniprot id: A0A8D0P588
uniprot id: M9V7C8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9823:LOC396866
gene id: 9823:LOC396866
uniprot id: Q28988
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Cytoplasm
messages: This is an intracellular thiol proteinase inhibitor.

9823:LOC100622387
gene id: 9823:LOC100622387
uniprot id: A0A4X1VJH6
uniprot id: F2Z587
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:LOC100624276
gene id: 9823:LOC100624276
uniprot id: A0A4X1SUK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:C3H16orf72
gene id: 9823:C3H16orf72
uniprot id: A0A8D0NYF6
uniprot id: I3LPV6
names: Similarity
messages: Belongs to the TAPR1 family.

9823:ALDH3B1
gene id: 9823:ALDH3B1
uniprot id: A0A0K1TQQ2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9823:RNF19A
gene id: 9823:RNF19A
uniprot id: Q2VJ60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. RNF19 subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR.
messages: Interacts with UBE2L3 and UBE2L6. Also interacts with transcription factor Sp1. Interacts with SNCAIP, CASR and VCP (By similarity).
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
messages: Membrane
messages: centrosome

9823:PSD3
gene id: 9823:PSD3
uniprot id: A0A287AHS5
uniprot id: A0A8D0KAU8
names: Subcellular Location Annotation
messages: ruffle membrane

9823:EPHA4
gene id: 9823:EPHA4
uniprot id: B5M6R3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9823:WIPI2
gene id: 9823:WIPI2
uniprot id: A0A4X1TLW8
uniprot id: D7RA31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure membrane

9823:SYT1
gene id: 9823:SYT1
uniprot id: A0A480P6K7
uniprot id: A0A8D1KVE2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

9823:AMELX
gene id: 9823:AMELX
uniprot id: P45561
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: A number of other isoforms are produced by carboxy-terminal processing.
messages: Belongs to the amelogenin family.
messages: Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.
messages: extracellular matrix

9823:MRPL14
gene id: 9823:MRPL14
uniprot id: A0A287BSR7
uniprot id: A0A4X1V5Z4
uniprot id: A0A8D1JL53
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9823:NDRG4
gene id: 9823:NDRG4
uniprot id: A0A480VA01
uniprot id: A0A4X1UX72
uniprot id: A0A8D2A708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: cytosol

9823:DPRX
gene id: 9823:DPRX
uniprot id: A0A480EEG2
names: Subcellular Location Annotation
messages: Nucleus

9823:P2RX3
gene id: 9823:P2RX3
uniprot id: A0A4X1VK46
uniprot id: I3L7H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9823:LOC100521607
gene id: 9823:LOC100521607
uniprot id: A0A4X1TVG1
uniprot id: A0A5G2QZB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GPC2
gene id: 9823:GPC2
uniprot id: F1RNM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9823:FOS
gene id: 9823:FOS
uniprot id: A0A140TAJ8
uniprot id: A0A4X1TB96
uniprot id: O97930
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Fos subfamily.
messages: Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232 (By similarity).
messages: Endoplasmic reticulum
messages: Heterodimer; with JUN (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1-binding site (By similarity). Interacts with SMAD3; the interaction is weak even on TGF-beta activation (By similarity). Interacts with MAFB (By similarity). Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with CDS1 and PI4K2A (By similarity). Interacts (via bZIP domain and leucine-zipper region) with the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF) subunits SMARCB1, SMARCC2 and SMARCD1 (By similarity). Interacts (via bZIP domain and leucine-zipper region) with ARID1A (By similarity).
messages: In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the association with endoplasmic reticulum membranes and activation of phospholipid synthesis (By similarity).
messages: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
messages: Nucleus
messages: Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity).
messages: cytosol

9823:CBLC
gene id: 9823:CBLC
uniprot id: A0A480QW23
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9823:C1H6orf120
gene id: 9823:C1H6orf120
uniprot id: A0A4X1VX98
uniprot id: I3LL77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
messages: Secreted

9823:PEBP4
gene id: 9823:PEBP4
uniprot id: A0A4X1VFH2
uniprot id: C4TP28
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9823:PRDX5
gene id: 9823:PRDX5
uniprot id: Q9GLW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Peroxisome matrix
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

9823:WFIKKN2
gene id: 9823:WFIKKN2
uniprot id: A0A8D1CYZ3
names: Similarity
messages: Belongs to the WFIKKN family.

9823:SET
gene id: 9823:SET
uniprot id: A0A8D1MIR7
uniprot id: F1RR69
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9823:TP53I11
gene id: 9823:TP53I11
uniprot id: A0A286ZVX6
uniprot id: A0A8D1R9I5
names: Subcellular Location Annotation
messages: Membrane

9823:SPCS2
gene id: 9823:SPCS2
uniprot id: A0A8D1S1R0
uniprot id: F1SUP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC100736951
gene id: 9823:LOC100736951
uniprot id: A0A4X1T4B8
uniprot id: F1SNU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9823:PTGES3
gene id: 9823:PTGES3
uniprot id: A0A5G2QTM2
uniprot id: A0A8D1UEM7
uniprot id: A0A8D1YC89
uniprot id: F1SL99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9823:SNRPC
gene id: 9823:SNRPC
uniprot id: A0A287BG27
uniprot id: A0A4X1T4T3
uniprot id: A0A4X1T4T8
uniprot id: F1RZ16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

9823:SSTR1
gene id: 9823:SSTR1
uniprot id: A0A4X1TBQ1
uniprot id: A0A8D1U7Z5
uniprot id: F6Q6G5
uniprot id: Q866U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:KRT8
gene id: 9823:KRT8
uniprot id: A0A4X1WBI1
names: Similarity
messages: Belongs to the intermediate filament family.

9823:LOC100518239
gene id: 9823:LOC100518239
uniprot id: A0A4X1SWA3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:UCP3
gene id: 9823:UCP3
uniprot id: O97649
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity).

9823:ZP3
gene id: 9823:ZP3
uniprot id: P42098
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: All cysteine residues are involved in disulfide bonds.
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for zona matrix formation. May not have a sperm-binding activity by itself but may increase sperm-binding activity of ZPB.
messages: Expressed in oocytes.
messages: O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.
messages: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. Interacts with ZP1 and ZP2.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9823:CD151
gene id: 9823:CD151
uniprot id: A0A4X1VSR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:IFN-OMEGA-4
gene id: 9823:IFN-OMEGA-4
uniprot id: A0A4X1WC30
uniprot id: C8CKC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:DYRK1A
gene id: 9823:DYRK1A
uniprot id: A0A287AIV4
uniprot id: A0A4X1TR90
uniprot id: A0A5G2QQP5
uniprot id: A0A8D1KML8
uniprot id: A0A8D1N0F3
uniprot id: I3L9V1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9823:GATA4
gene id: 9823:GATA4
uniprot id: A0A8D0RFM0
uniprot id: A0A8D1K2Y5
uniprot id: I3LUZ9
uniprot id: Q8MIM5
names: Subcellular Location Annotation
messages: Nucleus

9823:IRF2
gene id: 9823:IRF2
uniprot id: A0A287AQM5
uniprot id: A0A4X1VRU1
uniprot id: A0A4X1VW94
uniprot id: A0A8D1P6L6
uniprot id: F1RSZ7
uniprot id: K7GKU5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:NDUFAF3
gene id: 9823:NDUFAF3
uniprot id: A0A4X1SZ90
uniprot id: F1SKI6
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9823:USP51
gene id: 9823:USP51
uniprot id: A0A4X1VGU6
uniprot id: F1RTR5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9823:COX6C
gene id: 9823:COX6C
uniprot id: A0A4X1TXH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9823:GLYCTK
gene id: 9823:GLYCTK
uniprot id: A0A4X1VIM6
uniprot id: F1SIX9
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9823:LOC110255239
gene id: 9823:LOC110255239
uniprot id: A0A287BQ80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:AKIRIN2
gene id: 9823:AKIRIN2
uniprot id: A0A287BDC1
uniprot id: A0A4X1VIF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the akirin family.
messages: Cytoplasm
messages: Homodimer. Interacts with IPO9; the interaction is direct. Associates with 20S and 26S proteasomes (By similarity). Interacts with SMARCD1; promoting SWI/SNF complex recruitment. Interacts with NFKBIZ (By similarity). Interacts with YWHAB (By similarity).
messages: Membrane
messages: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (PubMed:25686036, PubMed:28327665).
messages: Nucleus
messages: Widely expressed (PubMed:22537061). Most abundant in the lung, followed by the skeletal muscle, heart, liver, fat, thymus, lymph node, small intestine, kidney and spleen (PubMed:22537061). In skeletal muscle, expressed at higher level in fast extensor digitorum longus (EDL) and longissimus lumborum (LL) muscles than in slow soleus (SOL) muscles (PubMed:25686036).

9823:ABRACL
gene id: 9823:ABRACL
uniprot id: A0A4X1VHY8
names: Similarity
messages: Belongs to the costars family.

9823:LOC100517880
gene id: 9823:LOC100517880
uniprot id: A0A286ZIV4
uniprot id: A0A4X1UMR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PMAP-36
gene id: 9823:PMAP-36
uniprot id: P49931
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Exerts antimicrobial activity against both Gram-positive and negative bacteria. Its activity appears to be mediated by its ability to damage bacterial membranes.
messages: Secreted

9823:PDCD4
gene id: 9823:PDCD4
uniprot id: A0A480HSI3
uniprot id: A0A4X1TG29
names: Similarity
messages: Belongs to the PDCD4 family.

9823:TP53INP1
gene id: 9823:TP53INP1
uniprot id: A0A287BG33
uniprot id: A0A4X1U3B3
uniprot id: A0A8D1P3P5
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9823:VPS4A
gene id: 9823:VPS4A
uniprot id: A0A4X1SFZ5
uniprot id: A0A8D1Z8E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9823:ADCYAP1
gene id: 9823:ADCYAP1
uniprot id: A0A287BEZ0
uniprot id: A0A4X1VPG7
uniprot id: P41535
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucagon family.
messages: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
messages: Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
messages: Secreted

9823:SEMA4D
gene id: 9823:SEMA4D
uniprot id: A0A5K1TV69
uniprot id: A0A8D1AJA6
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ST3GAL3
gene id: 9823:ST3GAL3
uniprot id: A0A4X1W822
uniprot id: Q70D54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:CHRNB4
gene id: 9823:CHRNB4
uniprot id: A0A4X1UTL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:EFNA2
gene id: 9823:EFNA2
uniprot id: A0A4X1VP93
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:CDKN3
gene id: 9823:CDKN3
uniprot id: Q9MYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity (By similarity).
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity).
messages: perinuclear region

9823:LDLR
gene id: 9823:LDLR
uniprot id: Q28832
uniprot id: W0G5E7
names: Caution
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
messages: Cell membrane
messages: Defects in LDLR are the cause of familial hypercholesterolemia (FH).
messages: Early endosome
messages: Golgi apparatus
messages: Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts (via NPXY motif) with LDLRAP1 (via PID domain). Interacts with ARRB1. Interacts with SNX17. Interacts with the full-length immature form of PCSK9 (via C-terminus).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: N- and O-glycosylated.
messages: The NPXY motif mediates the interaction with the clathrin adapter DAB2 and with LDLRAP1 which are involved in receptor internalization. A few residues outside the motif also play a role in the interaction.
messages: Ubiquitinated by MYLIP leading to degradation.
messages: clathrin-coated pit

9823:LOC100157348
gene id: 9823:LOC100157348
uniprot id: A0A8D1QBA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PLAGL2
gene id: 9823:PLAGL2
uniprot id: A0A4X1SW12
uniprot id: F1S523
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9823:BATF
gene id: 9823:BATF
uniprot id: A0A4X1TAI6
uniprot id: I3LGN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9823:EIF3K
gene id: 9823:EIF3K
uniprot id: A0A480THF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9823:PPP1R14A
gene id: 9823:PPP1R14A
uniprot id: O18734
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Detected in aorta smooth muscle and bladder.
messages: Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
messages: Phosphorylation of Thr-38 induces a conformation change.

9823:RAB33A
gene id: 9823:RAB33A
uniprot id: A0A4X1W977
uniprot id: Q06AU8
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9823:IPO4
gene id: 9823:IPO4
uniprot id: A0A4X1SNX2
uniprot id: F1SGN4
names: Subcellular Location Annotation
messages: Cytoplasm

9823:RARS
gene id: 9823:RARS
uniprot id: A0A8D1RIW8
uniprot id: F1RR89
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9823:ALDH6A1
gene id: 9823:ALDH6A1
uniprot id: A0A4X1TI23
uniprot id: F1S3H1
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9823:QTRT1
gene id: 9823:QTRT1
uniprot id: A0A8D1V2F0
uniprot id: F1S586
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

9823:POLR2K
gene id: 9823:POLR2K
uniprot id: A0A4X1TRS6
uniprot id: I3LN51
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9823:SEC22C
gene id: 9823:SEC22C
uniprot id: A0A287AJP5
uniprot id: A0A8D1EXM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9823:WDFY1
gene id: 9823:WDFY1
uniprot id: A0A287AXD6
uniprot id: A0A4X1UAW7
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9823:DEFB121
gene id: 9823:DEFB121
uniprot id: A0A8E8LS78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:MYOZ2
gene id: 9823:MYOZ2
uniprot id: A0A8D1FHH2
uniprot id: Q1AG08
names: Similarity
messages: Belongs to the myozenin family.

9823:IRF7
gene id: 9823:IRF7
uniprot id: A0A4X1VZ72
uniprot id: A0ZVR0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:GHSR
gene id: 9823:GHSR
uniprot id: Q95254
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Pituitary and hypothalamus.
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

9823:GPX4
gene id: 9823:GPX4
uniprot id: P36968
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutathione peroxidase family.
messages: Cytoplasm
messages: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (PubMed:3978121, PubMed:2386798, PubMed:8135530). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (PubMed:8135530, PubMed:2386798, PubMed:3978121). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (PubMed:8617728).
messages: Mitochondrion
messages: Monomer (PubMed:3978121). Has a tendency to form higher mass oligomers (By similarity).

9823:SIX4
gene id: 9823:SIX4
uniprot id: A0A286ZV22
uniprot id: A0A4X1W7E9
names: Subcellular Location Annotation
messages: Nucleus

9823:PNP
gene id: 9823:PNP
uniprot id: A0A287AM78
uniprot id: A0A4X1UWK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9823:PLG
gene id: 9823:PLG
uniprot id: P06867
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Cannot be activated with streptokinase.
messages: In the presence of the inhibitor, the activation involves only cleavage after Arg-579, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide (By similarity).
messages: Interacts with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation. Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4. Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin.
messages: Kringle domains mediate interaction with CSPG4.
messages: N-linked glycan contains N-acetyllactosamine, sialic acid and is core fucosylated. O-linked glycans consist of Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues (microheterogeneity).
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity).
messages: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.
messages: Secreted

9823:RABAC1
gene id: 9823:RABAC1
uniprot id: A0A4X1SGI1
uniprot id: A0A5G2R295
uniprot id: Q52NJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA1 family.
messages: Cell membrane
messages: Cytoplasm
messages: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1.
messages: Golgi apparatus
messages: Homodimer. Interacts with VAMP2 (synaptobrevin-2), prenylated Rab proteins, GDI1, NRDG1 and PCLO (By similarity).
messages: Membrane
messages: synaptic vesicle

9823:LYRM7
gene id: 9823:LYRM7
uniprot id: A0A287ADQ4
uniprot id: A0A4X1UM46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9823:LGI3
gene id: 9823:LGI3
uniprot id: A0A287BHH5
uniprot id: A0A8D2CIN8
names: Subcellular Location Annotation
messages: Secreted

9823:TBPL1
gene id: 9823:TBPL1
uniprot id: A0A4X1VBG0
uniprot id: I3LRL0
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9823:NXPH2
gene id: 9823:NXPH2
uniprot id: A0A287BFD3
uniprot id: A0A4X1SZQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9823:PSEN1
gene id: 9823:PSEN1
uniprot id: A0A4X1TMQ9
uniprot id: F1S3K9
uniprot id: Q0MS44
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9823:PPT1
gene id: 9823:PPT1
uniprot id: A0A8D1MRV7
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9823:CXCL13
gene id: 9823:CXCL13
uniprot id: A0A287A706
uniprot id: A0A4X1SVT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9823:MMD
gene id: 9823:MMD
uniprot id: A0A286ZL58
uniprot id: A0A4X1V9I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9823:BLOC1S6
gene id: 9823:BLOC1S6
uniprot id: A0A4X1SDS9
uniprot id: A5A778
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9823:CORO2A
gene id: 9823:CORO2A
uniprot id: A0A480XGM3
uniprot id: A0A4X1TZM0
names: Similarity
messages: Belongs to the WD repeat coronin family.

9823:KIAA2013
gene id: 9823:KIAA2013
uniprot id: A0A287BA35
uniprot id: A0A4X1W7D1
uniprot id: A0A8D0YW21
uniprot id: F1RF78
names: Subcellular Location Annotation
messages: Membrane

9823:IFN-DELTA-4
gene id: 9823:IFN-DELTA-4
uniprot id: A0A8D0IZE7
uniprot id: C8CKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:NUBP2
gene id: 9823:NUBP2
uniprot id: A0A286ZPJ6
uniprot id: A0A4X1VT84
uniprot id: A0A8D1JF77
uniprot id: F1RG29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9823:SPPL3
gene id: 9823:SPPL3
uniprot id: A0A8D0KH60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9823:LOC102161660
gene id: 9823:LOC102161660
uniprot id: A0A8D1FKD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CASR
gene id: 9823:CASR
uniprot id: A0A480EVE4
uniprot id: A0A8D1ZVM4
uniprot id: L0HSA9
uniprot id: O62714
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (By similarity).
messages: Homodimer; disulfide-linked. Interacts with VCP and RNF19A (By similarity). Interacts with ARRB1 (By similarity).
messages: In resting state, adopts an open conformation, anion-binding promoting the inactive configuration (By similarity). Upon aromatic amino acid-binding, the groove in the extracellular venus flytrap module is closed, thereby inducing the formation of a novel homodimer interface between subunits (By similarity). Calcium ions stabilize the active state by enhancing homodimer interactions between membrane-proximal domains to fully activate the receptor (By similarity). In contrast to human protein, not activated by AMG 416, a D-amino acid-containing peptide agonist: this is probably due to the absence of a Cys residue at position 482, which forms a disulfide bond with the AMG 416 peptide agonist in human and that is replaced by a Tyr residue in pig (PubMed:26290606).
messages: Membrane
messages: N-glycosylated.
messages: The extracellular regions of the homodimer interact in a side-by-side fashion while facing opposite directions. Each extracellular region consists of three domains, LB1 (ligand-binding 1), LB2 and CR (cysteine-rich). The two lobe-shaped domains LB1 and LB2 form a venus flytrap module. In the inactive configuration, the venus flytrap modules of both protomers are in the open conformation associated with the resting state (open-open) and the interdomain cleft is empty. In addition, each protomer contains three anions, which reinforce the inactive conformation, and one calcium ion. In the active configuration, both protomers of extracellular regions have the closed conformation associated with agonist-binding (closed-closed). The ligand-binding cleft of each protomer is solely occupied by an aromatic amino-acid. Calcium is bound at four novel sites, including one at the homodimer interface. Agonist-binding induces large conformational changes within the extracellular region homodimer: first, the venus flytrap module of each protomer undergoes domain closure. Second, the LB2 regions of the two protomers approach each other, resulting in an expansion of the homodimer interactions involving LB2 domains. Third, the CR regions of the two subunits interact to form a large homodimer interface that is unique to the active state. The CR regions are brought into close contact by the motion involving LB2 since the two domains are rigidly associated within each subunit.
messages: Ubiquitinated by RNF19A; which induces proteasomal degradation.

9823:TFCP2L1
gene id: 9823:TFCP2L1
uniprot id: A0A4X1SFL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9823:SFT2D2
gene id: 9823:SFT2D2
uniprot id: A0A287AHI5
uniprot id: A0A4X1V3M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9823:CHGA
gene id: 9823:CHGA
uniprot id: A0A480ZDS7
uniprot id: P04404
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Binds calcium with a low-affinity.
messages: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.
messages: Inhibits low calcium-stimulated parathyroid cell secretion.
messages: Interacts with SCG3.
messages: O-glycosylated.
messages: Parathyroid CHGA is sulfated on tyrosine residues, whereas adrenal CHGA seems to be mainly sulfated on oligosaccharide residues.
messages: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
messages: Secreted
messages: Strongly inhibits glucose induced insulin release from the pancreas.
messages: neuronal dense core vesicle
messages: secretory vesicle

9823:INIP
gene id: 9823:INIP
uniprot id: A0A480MDH4
uniprot id: A0A4X1V4M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9823:PTPN6
gene id: 9823:PTPN6
uniprot id: A0A480TLF2
uniprot id: A0A4X1UYC7
uniprot id: A0A4X1UZH9
uniprot id: I3LKA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9823:CHN2
gene id: 9823:CHN2
uniprot id: A0A287BPP5
uniprot id: A0A4X1TK96
names: Function
messages: GTPase-activating protein for p21-rac.

9823:GJD2
gene id: 9823:GJD2
uniprot id: A0A287AL56
uniprot id: A0A4X1UM12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:JPT1
gene id: 9823:JPT1
uniprot id: A0A8D2A4Y0
uniprot id: F1RVX2
uniprot id: I7L9G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9823:CGA
gene id: 9823:CGA
uniprot id: P01219
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9823:VKORC1
gene id: 9823:VKORC1
uniprot id: A0A287B0I6
uniprot id: A0A4X1TJA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:FRRS1
gene id: 9823:FRRS1
uniprot id: A0A4X1TVL3
uniprot id: B2ZDZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9823:TAP1
gene id: 9823:TAP1
uniprot id: Q1ACV6
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9823:LOC100515647
gene id: 9823:LOC100515647
uniprot id: A0A4X1VKC0
uniprot id: F1SJ81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FAM162A
gene id: 9823:FAM162A
uniprot id: A0A8D0PQ51
uniprot id: I3LKD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9823:NOXRED1
gene id: 9823:NOXRED1
uniprot id: A0A287ATR4
uniprot id: A0A8D1PEI4
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9823:PRCP
gene id: 9823:PRCP
uniprot id: A0A287AQY0
uniprot id: A0A8D1IB55
names: Similarity
messages: Belongs to the peptidase S28 family.

9823:TRAPPC13
gene id: 9823:TRAPPC13
uniprot id: A0A480JZZ9
uniprot id: A0A480QEF3
uniprot id: A0A480VBA9
uniprot id: A0A4X1UT44
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9823:ADAMTS1
gene id: 9823:ADAMTS1
uniprot id: Q2N1I7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:AAR2
gene id: 9823:AAR2
uniprot id: A0A8D0WHX7
uniprot id: F1S484
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9823:ATP1B4
gene id: 9823:ATP1B4
uniprot id: A0A481AY03
uniprot id: Q9BDK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1. Does not associate with known Na,K-ATPase alpha-subunits (By similarity).
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Expressed in skeletal muscle (at protein level). Expressed during postnatal development in skeletal muscle and heart.
messages: May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).
messages: Membrane
messages: Nucleus inner membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9823:LOC100512650
gene id: 9823:LOC100512650
uniprot id: A0A287BC49
uniprot id: A0A4X1SNB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLC12A4
gene id: 9823:SLC12A4
uniprot id: A0A4X1UI23
uniprot id: O18887
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9823:NPRL2
gene id: 9823:NPRL2
uniprot id: A0A8D1G8F6
uniprot id: A0A8D1PRD1
names: Similarity
messages: Belongs to the NPR2 family.

9823:MB21D1
gene id: 9823:MB21D1
uniprot id: I3LM39
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-359, Lys-369 and Lys-389 inhibits the cyclic GMP-AMP synthase activity. Deacetylated upon cytosolic DNA challenge such as viral infections. Acetylation by KAT5 increases the cyclic GMP-AMP synthase activity by promoting DNA-binding and subsequent activation.
messages: Belongs to the mab-21 family.
messages: Binds 1 Mg(2+) per subunit (PubMed:23722159). Is also active with Mn(2+). Mn(2+)-activated enyzme forms an inverted pppGp(2'-5')A intermediate, suggesting a non-canonical but accelerated 2',3'-cGAMP cyclization without substrate flip-over. Mn(2+) ions are coordinated by triphosphate moiety of the inverted substrate, independent of the catalytic triad residues (PubMed:23722159) (By similarity).
messages: Cell membrane
messages: Chromosome
messages: Monomer in the absence of DNA. Homodimer in presence of dsDNA: forms a 2:2 dimer with two enzymes binding to two DNA molecules. Interacts with nucleosomes; interaction is mainly mediated via histones H2A and H2B and inactivates the nucleotidyltransferase activity by blocking DNA-binding and subsequent activation. Interacts with PQBP1 (via WW domain). Interacts with TRIM14; this interaction recruits USP14, leading to deubiquitinate and stabilize CGAS and promote type I interferon production. Interacts with ZCCHC3; promoting sensing of dsDNA by CGAS. Interacts (when not monomethylated) with (poly-ADP-ribosylated) PARP1; interaction takes place in the nucleus and prevents the formation of the PARP1-TIMELESS complex (By similarity). Interacts (when monomethylated) with SGF29; interaction with SGF29 prevents interaction with PARP1. Interacts with PCBP2; preventing the formation of liquid-like droplets in which CGAS is activated (By similarity).
messages: Monomethylated at Lys-481 by SETD7 (By similarity). Monomethylation promotes interaction with SGF29, preventing interaction between PARP1 nad SGF29. Demethylation by RIOX1 promotes interaction with PARP1, followed by PARP1 inactivation (By similarity).
messages: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23722159). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:23722159). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production. Preferentially binds long dsDNA (around 45 bp) and forms ladder-like networks that function cooperatively to stabilize individual cGAS-dsDNA complexes. Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm. Also acts as an innate immune sensor of infection by retroviruses by detecting the presence of reverse-transcribed DNA in the cytosol (By similarity). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA. Also detects the presence of DNA from bacteria (By similarity). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells. 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner. Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (By simila…
messages: Nucleus
messages: Palmitoylation at Cys-449 by ZDHHC18 impairs DNA-binding, thereby preventing the cyclic GMP-AMP synthase activity.
messages: Poly-ADP-ribosylation at Glu-165 by PARP1 impairs DNA-binding, thereby preventing the cyclic GMP-AMP synthase activity.
messages: Polyglutamylated by TTLL6 at Glu-261, leading to impair DNA-binding activity. Deglutamylated by AGBL5/CCP5 and AGBL6/CCP6.
messages: Proteolytically cleaved by apoptotic caspases during apoptosis, leading to its inactivation. The damage of the nucleus and the mitochondria during apoptosis leads to leakage of nuclear and mitochondrial DNA, which activate CGAS: cleavage and inactivation during apoptosis in required to prevent cytokine overproduction. Cleaved by CASP7 and CASP3 during virus-induced apoptosis, thereby inactivating it and preventing cytokine overproduction. Cleaved by CASP1 upon DNA virus infection; the cleavage impairs cGAMP production. Also cleaved by the pyroptotic CASP4 during non-canonical inflammasome activation; does not cut at the same sites than CASP1.
messages: Sumoylated at Lys-206 by TRIM38 in uninfected cells and during the early phase of viral infection, promoting its stability by preventing ubiquitination at Lys-260 and subsequent degradation. Desumoylated by SENP2 during the late phase of viral infection. Sumoylation at Lys-322, Lys-359 and Lys-369 prevents DNA-binding, oligomerization and nucleotidyltransferase activity. Desumoylation at Lys-322, Lys-359 and Lys-369 by SENP7 relieves inhibition and activates CGAS.
messages: The N-terminal disordered part (1-134) binds unspecifically dsDNA and expands the binding and moving range of CGAS on dsDNA (By similarity). The disordered and positively charged residues enhance CGAS-DNA phase separation by increasing the valencies of DNA-binding. The N-terminus is required to sense chromatin and its phosphorylation blocks its activation by chromatin DNA (By similarity). When the N-terminal part (1-134) is missing the protein bound to dsDNA homodimerizes (By similarity).
messages: The N-terminal disordered part (1-134) is phosphorylated by AURKB during the G2-M transition, blocking CGAS liquid phase separation and preventing activation. Phosphorylation at Tyr-190 by BLK promotes cytosolic retention. Localizes into the nucleus following dephosphorylation at Tyr-190 (By similarity). Phosphorylation at Ser-410 activates the nucleotidyltransferase activity. Dephosphorylation at Ser-410 by PPP6C impairs its ability to bind GTP, thereby inactivating it (By similarity). Phosphorylation at Ser-188 by PRKDC inhibits its cyclic GMP-AMP synthase activity by impairing homodimerization and activation (By similarity). Phosphorylation at Ser-278 by AKT (AKT1, AKT2 or AKT3) suppresses the nucleotidyltransferase activity. Phosphorylation at Ser-278 by CDK1 during mitosis leads to its inhibition, thereby preventing CGAS activation by self-DNA during mitosis. Dephosphorylated at Ser-278 by protein phosphatase PP1 upon mitotic exit (By similarity).
messages: The arginine-anchor tightly binds to the canonical H2A acidic-patch residues.
messages: The enzyme activity is strongly increased by double-stranded DNA (dsDNA), but not by single-stranded DNA or RNA (PubMed:23722159). DNA-binding induces the formation of liquid-like droplets in which CGAS is activated. Liquid-like droplets also create a selective environment that restricts entry of negative regulators, such as TREX1 or BANF1/BAF, allowing sensing of DNA (By similarity). A number of mechanisms exist to restrict its activity toward self-DNA. The nucleotidyltransferase activity is inhibited in the nucleus via its association with nucleosomes: interacts with the acidic patch of histones H2A and H2B, thereby blocking DNA-binding and subsequent activation (By similarity). CGAS is also inactive when associated with mitotic chromatin (By similarity). Chromatin-bound CGAS cannot be activated by exogenous DNA in mitotic cells: phosphorylation of the N-terminal disordered part by AURKB during the G2-M transition blocks CGAS liquid phase separation and activation (By similarity). Activity toward self-DNA is inhibited by BANF1/BAF upon acute loss of nuclear membrane integrity: BANF1/BAF acts by outcompeting CGAS for DNA-binding, thereby preventing CGAS activation (By similarity). DNA-induced activation at micronuclei is also limited by TREX1, which degrades micronuclear DNA upon nuclear envelope rupture, thereby preventing CGAS activation. Acetylation at Lys-359, Lys-369 and Lys-389 inhibits the cyclic GMP-AMP synthase activity. Acetylation by KAT5 increases the cyclic GMP-AMP synthase activity by promoting DNA-binding and subsequent activation (By similarity). Phosphorylation at Ser-278 suppresses the nucleotidyltransferase activity. Phosphorylation at Ser-410 promotes the cyclic GMP-AMP synthase activity (By similarity). Phosphorylation at Ser-188 inhibits its cyclic GMP-AMP synthase activity. Ubiquitination at Lys-359 via 'Lys-27'-linked polyubiquitination enhances the cyclic GMP-AMP synthase activity (By similarity). Monoubiquitination at Lys-322 promotes olig…
messages: Ubiquitinated at Lys-389 via 'Lys-48'-linked polyubiquitin chains, leading to its SQSTM1-mediated autophagic degradation. Interaction with TRIM14 promotes recruitment of USP14, leading to deubiquitinate Lys-389 and stabilize CGAS. Ubiquitinated at Lys-359 by RNF185 via 'Lys-27'-linked polyubiquitination, promoting CGAS cyclic GMP-AMP synthase activity (By similarity). Monoubiquitination at Lys-322 by TRIM56 promotes oligomerization and subsequent activation (By similarity). Monoubiquitination by TRIM41 promotes CGAS activation (By similarity). Ubiquitination at Lys-260 via 'Lys-48'-linked polyubiquitination promotes its degradation. Deubiquitination at Lys-260 by USP29 promotes its stabilization. Deubiquitinated by USP27X, promoting its stabilization (By similarity).
messages: Undergoes a liquid-like phase transition after binding to DNA, which is dependent on zinc.
messages: cytosol

9823:RAB5A
gene id: 9823:RAB5A
uniprot id: Q06AU6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Early endosome membrane
messages: Endosome membrane
messages: Interacts with GDI1; this promotes dissociation from membranes; phosphorylation at Ser-84 disrupts this interaction (By similarity). Interacts with GDI2; phosphorylation at Ser-84 disrupts the interaction (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with PIK3CB. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with RINL. Interacts with ALS2CL, SUN2, ZFYVE20 and RUFY1. Interacts with RABEP1; one RABEP1 homodimer binds two RAB5A chains, but at opposite sides of the dimer. Interacts with OCRL and INPP5F. May be a component of a complex composed of RAB5A, DYN2 and PIK3C3. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4). Interacts with CLN5. Interacts with APPL2 (By similarity). Interacts with F8A1/F8A2/F8A3 (By similarity). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity).
messages: Melanosome
messages: Membrane
messages: Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
messages: cytosol
messages: phagosome membrane
messages: ruffle

9823:DPH5
gene id: 9823:DPH5
uniprot id: A0A4X1TRW2
uniprot id: F1S569
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9823:FGG
gene id: 9823:FGG
uniprot id: A0A4X1SSS2
uniprot id: A0A5G2QUU1
uniprot id: A0A8D1U5L7
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9823:CEP55
gene id: 9823:CEP55
uniprot id: A0A4X1UUU8
uniprot id: F1SC81
names: Subcellular Location Annotation
messages: Cytoplasm

9823:SELENBP1
gene id: 9823:SELENBP1
uniprot id: A0A5G2R8J3
uniprot id: A0A8D0SVL5
uniprot id: A0A8D1SHN4
uniprot id: A0A8D1Z7M0
uniprot id: F1ST01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9823:CLDN25
gene id: 9823:CLDN25
uniprot id: A0A8D1CQI5
uniprot id: F1SM66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9823:GLO1
gene id: 9823:GLO1
uniprot id: A0A8D0PDF1
uniprot id: I3LDM7
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9823:RPL9
gene id: 9823:RPL9
uniprot id: A0A4X1V3Z6
uniprot id: I3LP78
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

9823:NSUN4
gene id: 9823:NSUN4
uniprot id: A0A8D1JPK7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9823:FBP1
gene id: 9823:FBP1
uniprot id: P00636
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
messages: Homotetramer.
messages: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. AMP binding affects the turnover of bound substrate and not the affinity for substrate. Fructose 2,6-bisphosphate acts as competitive inhibitor. Fructose 2,6-bisphosphate and AMP have synergistic effects.
messages: The molecule has a highly reactive cysteine residue (Cys-117 or Cys-129), which tends to form mixed disulfides (e.g. with homocystine) but is not essential for enzyme activity.

9823:WNT9A
gene id: 9823:WNT9A
uniprot id: A0A4X1UJI2
uniprot id: I3LTN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:LOC733635
gene id: 9823:LOC733635
uniprot id: Q1KLB3
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9823:SLCO1A2
gene id: 9823:SLCO1A2
uniprot id: A0A4X1VET9
uniprot id: A0A5K1U410
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:DKC1
gene id: 9823:DKC1
uniprot id: B7TJ11
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9823:LOC100624226
gene id: 9823:LOC100624226
uniprot id: A0A286ZQG3
uniprot id: F1RM98
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:GGCX
gene id: 9823:GGCX
uniprot id: A0A4X1W535
uniprot id: A0A5G2QEB8
names: Subcellular Location Annotation
messages: Membrane

9823:FRG1
gene id: 9823:FRG1
uniprot id: A0A480VFE7
uniprot id: A0A4X1U2Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9823:MRPL16
gene id: 9823:MRPL16
uniprot id: A0A480MAF3
uniprot id: A0A8D1RWV1
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9823:RPS11
gene id: 9823:RPS11
uniprot id: A0A4X1VTS2
uniprot id: F2Z4Y8
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9823:ERP29
gene id: 9823:ERP29
uniprot id: A0A4X1TD86
uniprot id: F1RJM2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: Melanosome

9823:IL16
gene id: 9823:IL16
uniprot id: Q76KI7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

9823:DUOX2
gene id: 9823:DUOX2
uniprot id: Q8HZK2
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: By forskolin and down-regulated by iodide (at protein level). By insulin.
messages: Cell junction
messages: Expressed in thyroid, and the digestive tract especially in stomach, cecum and sigmoidal colon (at protein level). Expressed in thyroid.
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: Heterodimer with DUOXA2; disulfide-linked. Interacts with TXNDC11, TPO and CYBA.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: N-glycosylated.
messages: The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide (By similarity).

9823:ATP6V0A1
gene id: 9823:ATP6V0A1
uniprot id: A0A287BC33
uniprot id: A0A480IX08
uniprot id: A0A4X1U3I6
uniprot id: A0A4X1U3K4
uniprot id: F1S1D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9823:PEBP1
gene id: 9823:PEBP1
uniprot id: A0A4X1TTH9
uniprot id: F1RKG8
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9823:UBE2F
gene id: 9823:UBE2F
uniprot id: A0A4X1T4L2
uniprot id: A0A4X1T7P4
uniprot id: A0A5G2Q7M6
uniprot id: A0A5G2Q7S5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:LOC100736663
gene id: 9823:LOC100736663
uniprot id: A0A4X1UYE2
uniprot id: F1SAN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:KIF16B
gene id: 9823:KIF16B
uniprot id: A0A5G2QMV1
uniprot id: A0A8D1KLH3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:LHPP
gene id: 9823:LHPP
uniprot id: A0A480STU2
uniprot id: A0A8D0R573
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9823:ALDH3A1
gene id: 9823:ALDH3A1
uniprot id: A0A4X1SZM1
uniprot id: F1SDC4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9823:LOC100517855
gene id: 9823:LOC100517855
uniprot id: A0A287ACH8
uniprot id: A0A4X1SMK3
names: Similarity
messages: Belongs to the SCO1/2 family.

9823:SPMI
gene id: 9823:SPMI
uniprot id: A0A8D0XIF2
uniprot id: I7HJH6
names: Caution
names: Similarity
messages: Belongs to the spermadhesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DDX49
gene id: 9823:DDX49
uniprot id: A0A4X1U6Y4
uniprot id: F1S7D9
names: Similarity
messages: Belongs to the DEAD box helicase family.

9823:MCHR1
gene id: 9823:MCHR1
uniprot id: Q5QPY1
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

9823:CFL2
gene id: 9823:CFL2
uniprot id: B2CZR7
uniprot id: Q5G6V9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).
messages: Nucleus matrix
messages: The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
messages: cytoskeleton

9823:TOMM7
gene id: 9823:TOMM7
uniprot id: A1XQS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom7 family.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).
messages: Mitochondrion outer membrane
messages: Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity).

9823:SREBF1
gene id: 9823:SREBF1
uniprot id: O97676
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SREBP family.
messages: COPII-coated vesicle membrane
messages: Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein (By similarity). Interacts with CEBPA, the interaction produces a transcriptional synergy. Interacts with LMNA (By similarity).
messages: Endoplasmic reticulum membrane
messages: Forms a tight complex with SCAP, the SCAP-SREBP complex, in the endoplasmic reticulum membrane.
messages: Golgi apparatus membrane
messages: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation.
messages: Nucleus
messages: Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-403 by SIK1 represses activity possibly by inhibiting DNA-binding.
messages: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (By similarity). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity).
messages: Processed in the Golgi apparatus, releasing the protein from the membrane. At low cholesterol the SCAP-SREBP complex is recruited into COPII vesicles for export from the endoplasmic reticulum. In the Golgi, complex SREBPs are cleaved sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain, releasing the transcription factor from the Golgi membrane.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Ubiquitinated; the nuclear form has a rapid turnover and is rapidly ubiquitinated and degraded by the proteasome in the nucleus.

9823:CCL19
gene id: 9823:CCL19
uniprot id: A0A8D1GKZ3
uniprot id: D0Z5W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:SFN
gene id: 9823:SFN
uniprot id: Q1W2G0
names: Similarity
messages: Belongs to the 14-3-3 family.

9823:FIGN
gene id: 9823:FIGN
uniprot id: A0A480UT36
uniprot id: A0A4X1VPL1
names: Similarity
messages: Belongs to the AAA ATPase family.

9823:IL2
gene id: 9823:IL2
uniprot id: A8D5G2
uniprot id: P26891
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9823:WLS
gene id: 9823:WLS
uniprot id: A0A4X1U8B3
uniprot id: A0A5G2QGA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9823:SLC6A19
gene id: 9823:SLC6A19
uniprot id: A0A4X1TH85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9823:PSMA1
gene id: 9823:PSMA1
uniprot id: A0A8D1EBK4
uniprot id: F2Z5L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9823:CDC37L1
gene id: 9823:CDC37L1
uniprot id: A0A4X1W8Y5
uniprot id: F1SK44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9823:PKIG
gene id: 9823:PKIG
uniprot id: Q7YQJ4
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9823:DEGS1
gene id: 9823:DEGS1
uniprot id: A0A8D1JYY1
uniprot id: I3LKA2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Membrane

9823:PRND
gene id: 9823:PRND
uniprot id: A0A286ZPV1
uniprot id: A0A4X1UG45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9823:PCMT1
gene id: 9823:PCMT1
uniprot id: P80895
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (By similarity). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
messages: Monomer.
messages: cytosol

9823:CTSH
gene id: 9823:CTSH
uniprot id: B2D1T2
uniprot id: O46427
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Composed of cathepsin H and mini chain; disulfide-linked. Cathepsin H may be split into heavy and light chain. All chains are held together by disulfide bonds.
messages: Important for the overall degradation of proteins in lysosomes.
messages: Lysosome

9823:RAD1
gene id: 9823:RAD1
uniprot id: A0A4X1TFI6
uniprot id: F1SND5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9823:GHRH
gene id: 9823:GHRH
uniprot id: A0A4X1TLW2
uniprot id: E0Y439
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9823:RMND1
gene id: 9823:RMND1
uniprot id: A0A287AVV0
uniprot id: A0A8D1QZ60
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9823:CRTC2
gene id: 9823:CRTC2
uniprot id: A0A8D2A0K4
uniprot id: F1SFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9823:CTSD
gene id: 9823:CTSD
uniprot id: Q4U1U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

9823:TMX2
gene id: 9823:TMX2
uniprot id: A0A8D0I5I8
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9823:MEOX2
gene id: 9823:MEOX2
uniprot id: Q95JA6
names: Subcellular Location Annotation
messages: Nucleus

9823:EMG1
gene id: 9823:EMG1
uniprot id: A0A4X1UWG9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9823:DYNLL2
gene id: 9823:DYNLL2
uniprot id: A0A4X1SJK3
uniprot id: F2Z536
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9823:TARBP2
gene id: 9823:TARBP2
uniprot id: A0A287BSF9
uniprot id: A0A4X1WAY9
uniprot id: A0A8D0S1W2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9823:GATM
gene id: 9823:GATM
uniprot id: P50441
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity).
messages: Expressed in placenta on days 75 and 90 of gestation.
messages: Homodimer.
messages: Kidney. Expressed biallelically in placenta.
messages: Mitochondrion inner membrane

9823:TRAPPC2
gene id: 9823:TRAPPC2
uniprot id: F1SRI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Nucleus
messages: Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with ENO1, PITX1, SF1, TRAPPC2L and TRAPPC3.
messages: Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity).
messages: perinuclear region

9823:MRPL4
gene id: 9823:MRPL4
uniprot id: A0A287B2W3
uniprot id: A0A287B9C4
uniprot id: A0A4X1V0L2
uniprot id: A0A4X1V5X9
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9823:EXOC3L1
gene id: 9823:EXOC3L1
uniprot id: A0A4X1UM37
uniprot id: F1RFW4
names: Similarity
messages: Belongs to the SEC6 family.

9823:INTS10
gene id: 9823:INTS10
uniprot id: A0A480KC81
uniprot id: A0A480KGS2
uniprot id: A0A4X1UBF9
uniprot id: A0A4X1UD89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9823:ZDHHC9
gene id: 9823:ZDHHC9
uniprot id: A0A4X1W997
uniprot id: F1RTH7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:NAGA
gene id: 9823:NAGA
uniprot id: B1PK16
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9823:GFOD1
gene id: 9823:GFOD1
uniprot id: A0A287B7W3
uniprot id: A0A4X1VRB7
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9823:LOC100524975
gene id: 9823:LOC100524975
uniprot id: A0A4X1V0K4
uniprot id: F1SA00
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:VPS72
gene id: 9823:VPS72
uniprot id: A0A287B4J5
uniprot id: A0A4X1W120
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9823:BNIP1
gene id: 9823:BNIP1
uniprot id: A0A4X1UAX1
uniprot id: F1SJY7
names: Subcellular Location Annotation
messages: Membrane

9823:HNRNPA1
gene id: 9823:HNRNPA1
uniprot id: A0A286ZPE3
uniprot id: A0A4X1W4Q9
uniprot id: A0A4X1WAJ4
uniprot id: Q06A94
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:KCNJ1
gene id: 9823:KCNJ1
uniprot id: A0A8D1DW95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9823:BMPR2
gene id: 9823:BMPR2
uniprot id: A0A4X1V8C6
uniprot id: F1SI16
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9823:LOC106504121
gene id: 9823:LOC106504121
uniprot id: A0A4X1VKV5
uniprot id: F1RVA0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:JAK2
gene id: 9823:JAK2
uniprot id: O19064
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813. Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity. Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity. Also phosphorylated by TEC (By similarity). Phosphorylated on tyrosine residues in response to interferon gamma signaling. Phosphorylated on tyrosine residues in response to a signaling cascade that is activated by increased cellular retinol (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Cytoplasm
messages: Endomembrane system
messages: Interacts with IL23R, SKB1 and STAM2 (By similarity). Interacts with EPOR. Interacts with LYN. Interacts with SIRPA. Interacts with SH2B1. Interacts with TEC (By similarity). Interacts with IFNGR2 (via intracellular domain) (By similarity). Interacts with LEPR (Isoform B) (By similarity). Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner. Interacts with STRA6 (By similarity). Interacts with ASB2; the interaction targets JAK2 for Notch-induced proteasomal degradation (By similarity).
messages: Mn(2+) was used in the in vitro kinase assay but Mg(2+) is likely to be the in vivo cofactor.
messages: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
messages: Nucleus
messages: Regulated by autophosphorylation, can both activate or decrease activity. Heme regulates its activity by enhancing the phosphorylation on Tyr-1007 and Tyr-1008.
messages: The N-terminal domain of JAKs mediates their interaction with cytokine/interferon/growth hormone receptors. Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1 (By similarity).
messages: Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes.

9823:TFAP2B
gene id: 9823:TFAP2B
uniprot id: A0A4X1UZ81
names: Similarity
messages: Belongs to the AP-2 family.

9823:ANPEP
gene id: 9823:ANPEP
uniprot id: A0A4X1U246
uniprot id: K7GMF9
uniprot id: P15145
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner.
messages: (Microbial infection) Interacts with TGEV and PRCoV spike glycoprotein.
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met-enkephalin but not cholecystokinin CCK8, neuromedin C (GRP-10), somatostatin-14, substance P and vasoactive intestinal peptide (PubMed:8963385). May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
messages: Cell membrane
messages: Homodimer. Interacts with SLC6A19 (By similarity).
messages: May undergo proteolysis and give rise to a soluble form.
messages: Membrane
messages: N- and O-glycosylated.
messages: Sulfated.

9823:RPL18A
gene id: 9823:RPL18A
uniprot id: A0A8D1UYD5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9823:NUDT2
gene id: 9823:NUDT2
uniprot id: P50584
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (PubMed:9147133). Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity).
messages: Divalent metal ions.
messages: Inhibited by fluoride ions.

9823:MAP4K2
gene id: 9823:MAP4K2
uniprot id: A0A287A9F0
uniprot id: A0A8D1LXC3
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9823:CD63
gene id: 9823:CD63
uniprot id: A0A4X1W430
uniprot id: F1SPK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9823:LOC100736633
gene id: 9823:LOC100736633
uniprot id: A0A8D1DCJ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:PBX2
gene id: 9823:PBX2
uniprot id: A0A4X1V7G0
uniprot id: A5A8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9823:TRPV2
gene id: 9823:TRPV2
uniprot id: F1SDE4
names: Subcellular Location Annotation
messages: Membrane

9823:VPS45
gene id: 9823:VPS45
uniprot id: A0A4X1SHS6
uniprot id: F1SDG5
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9823:OSBPL6
gene id: 9823:OSBPL6
uniprot id: A0A287BGE9
uniprot id: A0A287BP28
uniprot id: A0A8D0RXG1
uniprot id: A0A8D1VER8
names: Similarity
messages: Belongs to the OSBP family.

9823:ASPH
gene id: 9823:ASPH
uniprot id: A0A4X1V4I1
names: Subcellular Location Annotation
messages: Membrane

9823:CD3D
gene id: 9823:CD3D
uniprot id: Q764N2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells.
messages: Cell membrane
messages: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with coreceptors CD4 and CD8.

9823:STAM2
gene id: 9823:STAM2
uniprot id: A0A4X1SUT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9823:CCDC39
gene id: 9823:CCDC39
uniprot id: A0A4X1UYN7
uniprot id: F1SGC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: cilium axoneme

9823:CBR2
gene id: 9823:CBR2
uniprot id: Q29529
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Allosteric enzyme exhibiting negative cooperativity. Activated 2-5 fold by fatty acids.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: By glucocorticoids.
messages: Homotetramer.
messages: Lung (ciliated cells, non-ciliated bronchiolar cells and type-II alveolar pneumocytes). Low expression in all extrapulmonary tissues, including adipose tissue.
messages: May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism.
messages: Mitochondrion matrix
messages: Uses both NADP and NAD as substrates. Has a strong preference for NADP.

9823:KCNK10
gene id: 9823:KCNK10
uniprot id: A0A287AIG4
uniprot id: A0A287B930
uniprot id: A0A4X1SZF9
uniprot id: A0A4X1SZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:ADORA3
gene id: 9823:ADORA3
uniprot id: A0A8D0LQ04
uniprot id: F1SBN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9823:EIF3A
gene id: 9823:EIF3A
uniprot id: A0A8D1ETP6
uniprot id: F1S4P6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with EIF4G1. Also interacts with KRT7 and PIWIL2.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

9823:LOC100737385
gene id: 9823:LOC100737385
uniprot id: A0A8D0R355
uniprot id: F1SA36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLA-5
gene id: 9823:SLA-5
uniprot id: Q9TSW6
names: Similarity
messages: Belongs to the MHC class I family.

9823:NAP1L1
gene id: 9823:NAP1L1
uniprot id: A0A287AFP4
uniprot id: A0A4X1VU95
uniprot id: A0A8D1TYI9
uniprot id: F1SGD7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9823:KIF2B
gene id: 9823:KIF2B
uniprot id: A0A8D1QPI7
uniprot id: F1RSG0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:KCNJ11
gene id: 9823:KCNJ11
uniprot id: A0A5G2QCH2
uniprot id: A0A8D1KDB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9823:LOC100514941
gene id: 9823:LOC100514941
uniprot id: A0A4X1VS42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ADSS
gene id: 9823:ADSS
uniprot id: A4Z6H1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited competitively by AMP and IMP and non-competitively by fructose 1,6-bisphosphate.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Widely expressed.

9823:NR5A2
gene id: 9823:NR5A2
uniprot id: H9DUR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9823:TRUB1
gene id: 9823:TRUB1
uniprot id: A0A8D1KPG9
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9823:SESN2
gene id: 9823:SESN2
uniprot id: A0A4X1TPR3
uniprot id: A0A5G2QR10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9823:DDR1
gene id: 9823:DDR1
uniprot id: A0A287A959
uniprot id: A0A4X1VHZ5
uniprot id: A0A4X1VJ08
uniprot id: A0A4X1VJ19
uniprot id: Q767M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9823:RABGGTB
gene id: 9823:RABGGTB
uniprot id: A0A4X1ULX5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9823:CTBP2
gene id: 9823:CTBP2
uniprot id: A0A287AIK8
uniprot id: A0A4X1VAK6
uniprot id: A0A8D1ZZ14
uniprot id: F1SDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9823:KEF22 p11
gene id: 9823:KEF22_p11
uniprot id: O79876
uniprot id: Q71KK5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9823:ITIH1
gene id: 9823:ITIH1
uniprot id: Q29052
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITIH family.
messages: Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
messages: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin. Interacts with TNFAIP6 (via Link and CUB domains).
messages: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
messages: Secreted
messages: The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal.

9823:PAPOLG
gene id: 9823:PAPOLG
uniprot id: A0A287AHP5
uniprot id: A0A4X1WBM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

9823:CMC4
gene id: 9823:CMC4
uniprot id: A0A4X1T8D6
names: Similarity
messages: Belongs to the CMC4 family.

9823:GRM1
gene id: 9823:GRM1
uniprot id: A0A4X1VP89
uniprot id: F1S737
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9823:OAZ2
gene id: 9823:OAZ2
uniprot id: A0A8D2C852
uniprot id: B2CR16
names: Similarity
messages: Belongs to the ODC antizyme family.

9823:CDC37
gene id: 9823:CDC37
uniprot id: A0A4X1V502
uniprot id: Q684M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9823:LOC100516295
gene id: 9823:LOC100516295
uniprot id: A0A4X1TWR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9823:RPL15
gene id: 9823:RPL15
uniprot id: A0A286ZL65
uniprot id: A0A4X1UNF3
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9823:POPDC2
gene id: 9823:POPDC2
uniprot id: B8Q0B3
names: Similarity
messages: Belongs to the popeye family.

9823:LOC100513390
gene id: 9823:LOC100513390
uniprot id: A0A5G2QF43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:VPS11
gene id: 9823:VPS11
uniprot id: A0A4X1SIU4
uniprot id: F1SAH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9823:STAT1
gene id: 9823:STAT1
uniprot id: Q764M5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with African swine fever virus (ASFV) MGF360-9L; this interaction mediates degradation of STAT1 through apoptosis.
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Has been shown to be mono-ADP-ribosylated at Glu-657 and Glu-705 by PARP14 which prevents phosphorylation at Tyr-701 (By similarity). However, the role of ADP-ribosylation in the prevention of phosphorylation has been called into question (By similarity). It has been suggested that the lack of phosphorylation may be due to sumoylation of Lys-703 (By similarity).
messages: Homodimerizes upon IFN-gamma induced phosphorylation. Heterodimer with STAT2 upon IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9. Interacts (phosphorylated at Ser-727) with PIAS1; the interaction results in release of STAT1 from its target gene. Interacts with IFNAR1. Interacts with IFNAR2. Found in a complex with NMI and CREBBP/CBP. Interacts with NMI which is required for CREBBP/CBP recruitment to the complex. Interacts with PTK2/FAK1. Interacts with SRC. Interacts with ERBB4 (phosphorylated). Interacts with PARP9 and DTX3L independently of IFN-beta or IFN-gamma-mediated STAT1 'Tyr-701' phosphorylation. Interacts with histone acetyltransferase EP300/p300 in response to INF-gamma stimulation. Interacts with OTOP1. Interacts with IFNGR1 (By similarity). Interacts with STAT4 (By similarity).
messages: ISGylated.
messages: Mono-ADP-ribosylated at Glu-657 and Glu-705 by PARP14; ADP-riboslyation prevents phosphorylation at Tyr-701. However, the role of ADP-ribosylation in the prevention of phosphorylation has been called into question and the lack of phosphorylation may be due to sumoylation of Lys-703.
messages: Monomethylated at Lys-525 by SETD2; monomethylation is necessary for phosphorylation at Tyr-701, translocation into the nucleus and activation of the antiviral defense.
messages: Nucleus
messages: Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via JAK2. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMK2/CAMKII in response to IFN-gamma stimulation, is required for maximal transcriptional activity. Phosphorylated on Ser-727 by CAMK2/CAMKII in response to IFN-gamma stimulation and calcium mobilization, promoting activity. Phosphorylated by CAMK2/CAMKII in response to IFN-beta stimulation and calcium mobilization in epithelial cells, promoting activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with PIAS. Phosphorylation on Ser-727 by PRKCD induces apoptosis in response to DNA-damaging agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC family kinase. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates interferon-mediated signaling. Upon viral infection or IFN induction, phosphorylation on Ser-708 occurs much later than phosphorylation on Tyr-701 and is required for the binding of ISGF3 on the ISREs of a subset of IFN-stimulated genes IKBKE-dependent. Phosphorylation at Tyr-701 and Ser-708 are mutually exclusive, phosphorylation at Ser-708 requires previous dephosphorylation of Tyr-701.
messages: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
messages: Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727, and by interaction with PIAS proteins. Enhances the transactivation activity.

9823:MMP23B
gene id: 9823:MMP23B
uniprot id: A0A480QKX0
names: Caution
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CD36
gene id: 9823:CD36
uniprot id: A0A4X1SIV0
uniprot id: Q3HUX1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

9823:VNN1
gene id: 9823:VNN1
uniprot id: Q9BDJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
messages: Cell membrane
messages: Detected in kidney (at protein level).
messages: Monomer.

9823:SCRN1
gene id: 9823:SCRN1
uniprot id: A0A287B8Z9
uniprot id: A0A8D0ZJX2
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9823:SH3GLB1
gene id: 9823:SH3GLB1
uniprot id: A0A288CG11
uniprot id: A0A4X1UB53
uniprot id: A0A4X1UCY7
uniprot id: A0A4X1UE41
uniprot id: A0A5G2QNQ3
uniprot id: A0A8D0QM53
uniprot id: D0G7F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9823:DSC1
gene id: 9823:DSC1
uniprot id: A0A8D1AR94
uniprot id: F1SAM0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9823:PPP4R3B
gene id: 9823:PPP4R3B
uniprot id: A0A4X1WBW1
uniprot id: F1SQL1
names: Similarity
messages: Belongs to the SMEK family.

9823:KCNC3
gene id: 9823:KCNC3
uniprot id: A0A287AXA6
uniprot id: A0A4X1VUW0
uniprot id: A0A8D2C8F5
uniprot id: F1RH35
names: Subcellular Location Annotation
messages: Membrane

9823:ZUFSP
gene id: 9823:ZUFSP
uniprot id: A0A4X1TE28
uniprot id: I3LH67
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9823:MRPL33
gene id: 9823:MRPL33
uniprot id: A0A286ZU68
uniprot id: A0A4X1TLP9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9823:C3H16orf91
gene id: 9823:C3H16orf91
uniprot id: A0A287B3G9
uniprot id: A0A8D1P905
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCSMST1 family.
messages: Membrane

9823:TCIRG1
gene id: 9823:TCIRG1
uniprot id: A0A8D1D0A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9823:RTN1
gene id: 9823:RTN1
uniprot id: A0A4X1WCX0
uniprot id: I3LBH0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:CHMP1A
gene id: 9823:CHMP1A
uniprot id: A0A4X1TD22
uniprot id: I3LU89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9823:LOC100156339
gene id: 9823:LOC100156339
uniprot id: A0A4X1UV01
uniprot id: A0A5G2R6A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LAMTOR1
gene id: 9823:LAMTOR1
uniprot id: A0A4X1V3R0
uniprot id: F2Z5W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9823:TMEM168
gene id: 9823:TMEM168
uniprot id: A0A4X1W654
uniprot id: F1SJB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

9823:WNT2B
gene id: 9823:WNT2B
uniprot id: A0A4X1T8G1
uniprot id: F1SBP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:TLR2
gene id: 9823:TLR2
uniprot id: A0A8D0TKU7
uniprot id: Q59HI8
uniprot id: Q6TN21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides.
messages: Membrane
messages: Membrane raft
messages: phagosome membrane

9823:ATP2C2
gene id: 9823:ATP2C2
uniprot id: A0A5G2QSB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:MAN2B1
gene id: 9823:MAN2B1
uniprot id: K9J4R3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9823:WDR62
gene id: 9823:WDR62
uniprot id: Q8HXL3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Can form homodimers (via C-terminus). Interacts (via C-terminus) with MAPKBP1 (via C-terminus). Interacts with CDK5RAP2, CEP152, CEP63 and KIAA0753. CEP63, CDK5RAP2, CEP152, WDR62 are proposed to form a stepwise assembled complex at the centrosome forming a ring near parental centrioles.
messages: Nucleus
messages: Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (By similarity). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity).
messages: centriole
messages: centrosome
messages: spindle pole

9823:RBP7
gene id: 9823:RBP7
uniprot id: A0A4X1W9N4
uniprot id: B9P3U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9823:TPRG1
gene id: 9823:TPRG1
uniprot id: A0A4X1UEG7
uniprot id: A0A8D0QKV4
uniprot id: F1SFH6
names: Similarity
messages: Belongs to the TPRG1 family.

9823:LOC100627324
gene id: 9823:LOC100627324
uniprot id: A0A4X1TY10
uniprot id: A0A5G2QE79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CACNG1
gene id: 9823:CACNG1
uniprot id: Q2MJQ7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: N-glycosylated.
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

9823:SEC24C
gene id: 9823:SEC24C
uniprot id: A0A286ZQ28
uniprot id: A0A8D1MF20
uniprot id: A0A8D1MFU5
uniprot id: F1SU53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9823:MED12
gene id: 9823:MED12
uniprot id: F1RSV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

9823:FURIN
gene id: 9823:FURIN
uniprot id: A0A8D1TM49
uniprot id: F1RMJ1
names: Similarity
messages: Belongs to the peptidase S8 family.

9823:IFN-ALPHA-10
gene id: 9823:IFN-ALPHA-10
uniprot id: Q304V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:APOOL
gene id: 9823:APOOL
uniprot id: A0A4X1W4W5
uniprot id: A0A5G2QPN0
uniprot id: A0A8D1RYM2
uniprot id: F1S1Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9823:ST3GAL1
gene id: 9823:ST3GAL1
uniprot id: A0A4X1SP39
uniprot id: F1RRV7
uniprot id: Q02745
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:19820709, PubMed:8288606). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:19820709, PubMed:8288606). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans (PubMed:19820709, PubMed:8288606). As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8288606). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8288606) (By similarity).
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Secreted
messages: Seems to lack a 40 residues internal segment.
messages: The long isoform is abundant in salivary gland, liver, lung, and colon mucosa. Both long and short forms are detected in submaxillary salivary glands.
messages: The soluble form derives from the membrane form by proteolytic processing.
messages: trans-Golgi network membrane

9823:EID1
gene id: 9823:EID1
uniprot id: A0A4X1SKU0
uniprot id: F1SQG2
names: Subcellular Location Annotation
messages: Nucleus

9823:TIPARP
gene id: 9823:TIPARP
uniprot id: A0A4X1SJL9
uniprot id: I3LQD6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9823:ESR1
gene id: 9823:ESR1
uniprot id: Q29040
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with coactivator NCOA5. Interacts with PELP1, the interaction is enhanced by 17-beta-estradiol; the interaction increases ESR1 transcriptional activity (By similarity). Interacts with NCOA7; the interaction is ligand-inducible. Interacts with AKAP13, CUEDC2, HEXIM1, KDM5A, MAP1S, SMARD1, and UBE1C. Interacts with MUC1; the interaction is stimulated by 7 beta-estradiol (E2) and enhances ESR1-mediated transcription. Interacts with DNTTIP2, and UIMC1. Interacts with KMT2D/MLL2. Interacts with ATAD2; the interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via its C-terminus). Interacts with MACROD1. Interacts with SH2D4A and PLCG. Interacts with SH2D4A; the interaction blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62; the interaction requires estradiol and appears to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with DNAAF4. Interacts with PRMT2. Interacts with RBFOX2. Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent. Interacts with FAM120B, FOXL2, PHB2 and SLC30A9. Interacts with coactivators NCOA3 and NCOA6. Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D. Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy. Interacts with DDX5. Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions. Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3. Interacts with NRIP1. Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts with CLOCK and the interaction is stimulated by…
messages: Cell membrane
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).
messages: Cytoplasm
messages: Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-260.
messages: Golgi apparatus
messages: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades.Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
messages: Nucleus
messages: Palmitoylated at Cys-447 by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor (By similarity).
messages: Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity (By similarity). Phosphorylated by LMTK3 (in vitro) (By similarity).
messages: Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1.

9823:ZNF397
gene id: 9823:ZNF397
uniprot id: A0A287B716
uniprot id: A0A4X1VCD0
names: Subcellular Location Annotation
messages: Nucleus

9823:KRT84
gene id: 9823:KRT84
uniprot id: A0A4X1WD65
names: Similarity
messages: Belongs to the intermediate filament family.

9823:LOC100153925
gene id: 9823:LOC100153925
uniprot id: A0A287AYE6
uniprot id: A0A8D0MQW1
uniprot id: A0A8D1F6T7
uniprot id: F1RK97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9823:HSPA8
gene id: 9823:HSPA8
uniprot id: A0A480ECX1
uniprot id: A0A4X1VJ17
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9823:STX2
gene id: 9823:STX2
uniprot id: A0A287BKT9
uniprot id: A0A8D0Z9W1
uniprot id: A0A8D1L671
uniprot id: F1RFQ6
names: Similarity
messages: Belongs to the syntaxin family.

9823:IFN-DELTA-5
gene id: 9823:IFN-DELTA-5
uniprot id: A0A4X1WC14
uniprot id: C8CKB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:UPK2
gene id: 9823:UPK2
uniprot id: Q95L04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the uroplakin-2 family.
messages: Cell membrane
messages: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).
messages: Expressed only in the urothelium. Localizes to urothelial superficial cells.
messages: Interacts with uroplakin-1a (UPK1A).

9823:NAPEPLD
gene id: 9823:NAPEPLD
uniprot id: A0A4X1VBA4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

9823:ZPR1
gene id: 9823:ZPR1
uniprot id: A0A4X1T2A9
uniprot id: F6QAP8
names: Similarity
messages: Belongs to the ZPR1 family.

9823:NDUFA12
gene id: 9823:NDUFA12
uniprot id: A0A4X1SJF2
uniprot id: F1SQP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:POLR3G
gene id: 9823:POLR3G
uniprot id: A0A4X1TD65
uniprot id: A0A8D0RL15
uniprot id: I3LJE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9823:KPNA7
gene id: 9823:KPNA7
uniprot id: C6K7I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin alpha family.
messages: Binds to importin subunit beta-1/KPNB1 via the IBB domain; this complex dissociates in the presence of RAN-GTP.
messages: Functions in nuclear protein import.
messages: Nucleus

9823:SYNDIG1L
gene id: 9823:SYNDIG1L
uniprot id: A0A4X1THB5
uniprot id: A0A4X1TJE8
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:ACSL5
gene id: 9823:ACSL5
uniprot id: D3K5K4
uniprot id: F1S5J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9823:C3H2orf40
gene id: 9823:C3H2orf40
uniprot id: A0A8D1KNN7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9823:LOC100521949
gene id: 9823:LOC100521949
uniprot id: A0A5G2QHN6
uniprot id: A0A8D1DQB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:WASHC1
gene id: 9823:WASHC1
uniprot id: A0A480TN39
uniprot id: A0A4X1ULF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WASH1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9823:KIF4A
gene id: 9823:KIF4A
uniprot id: A0A4X1VZK4
uniprot id: F1RTL0
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:APOC3
gene id: 9823:APOC3
uniprot id: P27917
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the apolipoprotein C3 family.
messages: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
messages: Secreted
messages: Synthesized predominantly in liver and to a lesser degree in intestine.

9823:PLAG1
gene id: 9823:PLAG1
uniprot id: A0A4X1SU15
uniprot id: F1RT54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9823:LOC100525745
gene id: 9823:LOC100525745
uniprot id: A0A8D1RVC8
names: Similarity
messages: Belongs to the intermediate filament family.

9823:CYP19A1
gene id: 9823:CYP19A1
uniprot id: Q29624
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
messages: Membrane

9823:NEU1
gene id: 9823:NEU1
uniprot id: A5PF10
uniprot id: B9TSS6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A C-terminal internalization signal (YGTL) appears to allow the targeting of plasma membrane proteins to endosomes.
messages: Belongs to the glycosyl hydrolase 33 family.
messages: Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity).
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with cathepsin A (protective protein), beta-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.
messages: Lysosome lumen
messages: Lysosome membrane
messages: N-glycosylated.
messages: Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane.

9823:THRSP
gene id: 9823:THRSP
uniprot id: A0A286ZQX5
uniprot id: A0A4X1UDV8
uniprot id: F8UX46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9823:SRP54
gene id: 9823:SRP54
uniprot id: A0A4X1T8Z2
uniprot id: F2Z5M9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle

9823:HR
gene id: 9823:HR
uniprot id: A3RGC0
names: Subcellular Location Annotation
messages: Nucleus

9823:SCNN1G
gene id: 9823:SCNN1G
uniprot id: A0A8D1WXS6
uniprot id: F1RPF1
names: Subcellular Location Annotation
messages: Membrane

9823:GALK1
gene id: 9823:GALK1
uniprot id: A0A4X1UWR1
uniprot id: F1RVY7
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9823:LOC100153325
gene id: 9823:LOC100153325
uniprot id: A0A4X1WC40
uniprot id: Q304W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:MYH1
gene id: 9823:MYH1
uniprot id: Q9TV61
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9823:HSPA13
gene id: 9823:HSPA13
uniprot id: A0A4X1UEW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

9823:LOC100524598
gene id: 9823:LOC100524598
uniprot id: A0A8D1HMZ8
uniprot id: F1SG16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9823:PHYKPL
gene id: 9823:PHYKPL
uniprot id: A0A287BCJ7
uniprot id: A0A4X1VWT8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9823:SPATS2L
gene id: 9823:SPATS2L
uniprot id: D5K895
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

9823:TAF11
gene id: 9823:TAF11
uniprot id: A0A4X1T4L0
uniprot id: A0A4X1T4L5
uniprot id: A0A5G2QQA7
uniprot id: F1RZ14
names: Similarity
messages: Belongs to the TAF11 family.

9823:POMGNT1
gene id: 9823:POMGNT1
uniprot id: A0A287AMB9
uniprot id: A0A4X1WAD9
uniprot id: A0A8D0W5S0
uniprot id: F1S3V2
uniprot id: Q0KKC1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9823:FKBP6
gene id: 9823:FKBP6
uniprot id: A0A480JS54
names: Function
names: Similarity
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

9823:EFNB3
gene id: 9823:EFNB3
uniprot id: A0A8D0YA40
uniprot id: A0A8D1L793
uniprot id: B0LDT4
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:HSD17B4
gene id: 9823:HSD17B4
uniprot id: Q28956
names: Subcellular Location Annotation
messages: Peroxisome

9823:ACSM5
gene id: 9823:ACSM5
uniprot id: A0A8D2A1H2
uniprot id: I3L882
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:HNMT
gene id: 9823:HNMT
uniprot id: A0A287AA45
uniprot id: A0A4X1SYB7
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9823:LOC100624150
gene id: 9823:LOC100624150
uniprot id: A0A287BHL8
uniprot id: A0A4X1U1T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TSHZ2
gene id: 9823:TSHZ2
uniprot id: A5GFT6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Interacts (via homeobox domain) with APBB1 (via PID domain 1).
messages: Nucleus
messages: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
messages: Sumoylated.

9823:ACSL6
gene id: 9823:ACSL6
uniprot id: A0A287ALQ2
uniprot id: A0A287BLC7
uniprot id: A0A480ZTJ9
uniprot id: A0A4X1UQB3
uniprot id: A0A4X1URX6
uniprot id: A0A8D0SIH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

9823:MAP3K14
gene id: 9823:MAP3K14
uniprot id: A0A8D1TWS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9823:SLC25A26
gene id: 9823:SLC25A26
uniprot id: A0A4X1VD62
uniprot id: F1SFS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:UBE2L3
gene id: 9823:UBE2L3
uniprot id: A0A8D1H6A2
uniprot id: A0A8D1NAI5
uniprot id: B8Y648
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:GRIK1
gene id: 9823:GRIK1
uniprot id: A0A286ZXH5
uniprot id: A0A286ZZZ7
uniprot id: A0A480ZRX9
uniprot id: A0A4X1U9Z3
uniprot id: A0A8D0ZAJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9823:MRPS18C
gene id: 9823:MRPS18C
uniprot id: A0A0M3KL54
uniprot id: A0A8D0T668
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9823:TMEM129
gene id: 9823:TMEM129
uniprot id: A0A287BLX0
uniprot id: A0A4X1T2H5
uniprot id: A0A4X1T2I2
uniprot id: F1S8S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9823:UCHL5
gene id: 9823:UCHL5
uniprot id: Q06AT3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by ADRM1. Inhibited by interaction with NFRKB (By similarity).
messages: Belongs to the peptidase C12 family.
messages: Component of the 19S (PA700) regulatory complex of the 26S proteasome. Interacts with ADRM1 and NFRKB. Component of the INO80 complex; specifically part of a complex module associated with N-terminus of INO80 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity).

9823:CRX
gene id: 9823:CRX
uniprot id: A0A4X1W2N1
names: Subcellular Location Annotation
messages: Nucleus

9823:MYOZ1
gene id: 9823:MYOZ1
uniprot id: Q4PS85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myozenin family.
messages: Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT (By similarity).
messages: Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity).
messages: Nucleus
messages: pseudopodium

9823:C7H6orf125
gene id: 9823:C7H6orf125
uniprot id: A0A287B747
uniprot id: A0A4X1T8G3
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9823:E2F8
gene id: 9823:E2F8
uniprot id: A0A287AUT3
uniprot id: A0A8D1Y9P1
uniprot id: A0A8D2C563
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9823:LOC100520042
gene id: 9823:LOC100520042
uniprot id: A0A8D0IF48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:GRPEL1
gene id: 9823:GRPEL1
uniprot id: A0A8D0PZ52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9823:IGFBP6
gene id: 9823:IGFBP6
uniprot id: A0A480VX05
uniprot id: A0A4X1WBI4
uniprot id: A6ZIC9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:KRT36
gene id: 9823:KRT36
uniprot id: A0A5G2R1F9
uniprot id: A0A8D0ZEJ1
names: Similarity
messages: Belongs to the intermediate filament family.

9823:INHA
gene id: 9823:INHA
uniprot id: P04087
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein.
messages: Secreted

9823:CRLS1
gene id: 9823:CRLS1
uniprot id: A0A4X1UGI3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9823:PLCD4
gene id: 9823:PLCD4
uniprot id: Q8SPR7
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 5 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity).
messages: Interacts with GRIP1 (By similarity). Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunit GNAI3 (inactive GDP-bound form); low-affinity interaction (By similarity).
messages: Membrane
messages: Nucleus
messages: The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.
messages: The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).
messages: The PDZ-binding motif mediates the interaction with GRIP1.
messages: The PH domain is not a critical determinant of the membrane localization.

9823:DGAT1
gene id: 9823:DGAT1
uniprot id: Q8MHZ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9823:NPM2
gene id: 9823:NPM2
uniprot id: A0A4X1VH60
uniprot id: D3K5P0
names: Similarity
messages: Belongs to the nucleoplasmin family.

9823:YIPF2
gene id: 9823:YIPF2
uniprot id: A0A481CLA2
uniprot id: A0A4X1VD29
uniprot id: F1S589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9823:CYP20A1
gene id: 9823:CYP20A1
uniprot id: A0A0H4IRA9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:LOC106504900
gene id: 9823:LOC106504900
uniprot id: A0A4X1TMU9
uniprot id: A0A5G2QGW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CRHBP
gene id: 9823:CRHBP
uniprot id: D3K5L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9823:TARS2
gene id: 9823:TARS2
uniprot id: A0A480WLU7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9823:MYO1E
gene id: 9823:MYO1E
uniprot id: A0A287BEA3
uniprot id: A0A4X1TQX9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9823:RAD21
gene id: 9823:RAD21
uniprot id: A0A4X1T8I2
uniprot id: F1S1K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9823:PLK3
gene id: 9823:PLK3
uniprot id: A0A4X1W400
uniprot id: F1S348
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9823:PPP1CC
gene id: 9823:PPP1CC
uniprot id: A0A4X1U451
uniprot id: Q2EHH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cleavage furrow
messages: Midbody
messages: microtubule organizing center
messages: nucleolus
messages: nucleoplasm

9823:LOC100515649
gene id: 9823:LOC100515649
uniprot id: A0A5G2R5D4
uniprot id: A0A8D0YC59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RPS6KA6
gene id: 9823:RPS6KA6
uniprot id: A0A480L5M3
uniprot id: A0A4X1W4I4
uniprot id: A0A8D1G9J3
uniprot id: F1S1R0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9823:UBE2D1
gene id: 9823:UBE2D1
uniprot id: A0A4X1VCP6
uniprot id: Q06AA8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:ABL1
gene id: 9823:ABL1
uniprot id: A0A287BB27
uniprot id: A0A8D1H808
uniprot id: A0A8D1HDM8
uniprot id: F1S0X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:EFNB2
gene id: 9823:EFNB2
uniprot id: B0LDS8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:GNMT
gene id: 9823:GNMT
uniprot id: Q29555
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in liver.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.
messages: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate (PubMed:8281755). Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine (By similarity).
messages: Cytoplasm
messages: Homotetramer.
messages: Inhibited by 5-methyltetrahydrofolate monoglutamate and by 5-methyltetrahydrofolate pentaglutamate, inhibition is much more effective by the pentaglutamate form than by the monoglutamate form. Two molecules of 5-methyltetrahydrofolate are bound per tetramer. The binding sites are localized between subunits. Inhibitor binding may preclude movements of the polypeptide chain that are necessary for enzyme activity.

9823:ENPP2
gene id: 9823:ENPP2
uniprot id: A0A286ZKF8
uniprot id: A0A287ATY3
uniprot id: A0A287B762
uniprot id: A0A480K6K5
uniprot id: A0A480R8I2
uniprot id: A0A8D0KAI0
uniprot id: A0A8D0UAP6
uniprot id: A0A8D1GXZ9
uniprot id: A0A8D1H3Q0
uniprot id: A0A8D1K9V8
uniprot id: A0A8D1YLB5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

9823:SPRY1
gene id: 9823:SPRY1
uniprot id: A0A4X1V8S7
uniprot id: F1RRA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

9823:NME1
gene id: 9823:NME1
uniprot id: A0A287AS29
uniprot id: A0A4X1V8M9
names: Similarity
messages: Belongs to the NDK family.

9823:PGM3
gene id: 9823:PGM3
uniprot id: F1RQM2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.
messages: Inhibited by Mn(2+), Cd(2+), Zn(2+), Cu(2+) and Be(2+).

9823:AHCYL2
gene id: 9823:AHCYL2
uniprot id: A0A287A100
uniprot id: A0A4X1VYW3
uniprot id: A0A4X1W051
uniprot id: A0A8D1H5S6
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9823:MMP19
gene id: 9823:MMP19
uniprot id: A0A4X1WB09
names: Similarity
messages: Belongs to the peptidase M10A family.

9823:EDN1
gene id: 9823:EDN1
uniprot id: P09558
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides (PubMed:2451132). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
messages: Secreted

9823:RNF13
gene id: 9823:RNF13
uniprot id: A0A287AZC7
uniprot id: A0A4X1SZC3
names: Subcellular Location Annotation
messages: Membrane

9823:CHST3
gene id: 9823:CHST3
uniprot id: A0A4X1T9E4
uniprot id: I3LU13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9823:MT3
gene id: 9823:MT3
uniprot id: P55944
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).
messages: Brain.

9823:CDC45
gene id: 9823:CDC45
uniprot id: A0A480WYQ3
uniprot id: A0A4X1UT27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9823:INSIG2
gene id: 9823:INSIG2
uniprot id: D2DXL3
uniprot id: Q6PQZ3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with RNF139. Interacts with RNF145.
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane
messages: Oxidized at Cys-215 in differentiated myotubes, preventing ubiquitination at the same site, and resulting in protein stabilization.
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139.
messages: Phosphorylation at Ser-151 by PCK1 reduces binding to oxysterol, disrupting the interaction between INSIG2 and SCAP, thereby promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes.
messages: Polyubiquitinated by AMFR/gp78 at Cys-215 in some tissues such as adipose tissues, undifferentiated myoblasts and liver, leading to its degradation. In differentiated myotubes, Cys-215 oxidation prevents ubiquitination at the same site, resulting in protein stabilization.
messages: The KxHxx motif mediates association with the coatomer complex.

9823:ELF1
gene id: 9823:ELF1
uniprot id: A0A286ZTG6
uniprot id: A0A287A1F3
uniprot id: A0A8D1AHQ5
uniprot id: A0A8D1AJK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:ART4
gene id: 9823:ART4
uniprot id: A0A8D1A5N2
uniprot id: A0A8D1I2Z6
uniprot id: Q95KR5
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9823:TLR8
gene id: 9823:TLR8
uniprot id: A0A4X1TK68
uniprot id: B3XXC2
uniprot id: Q865R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9823:ARRDC3
gene id: 9823:ARRDC3
uniprot id: A0A480YTQ3
uniprot id: A0A4X1TE19
names: Similarity
messages: Belongs to the arrestin family.

9823:TNFSF9
gene id: 9823:TNFSF9
uniprot id: A0A4X1VSK8
uniprot id: F1SBT1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:NTN1
gene id: 9823:NTN1
uniprot id: Q2HXW4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D. Binds to its receptor; DSCAM (By similarity). Interacts with APP (By similarity).
messages: Cytoplasm
messages: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity).
messages: Secreted

9823:ANXA5
gene id: 9823:ANXA5
uniprot id: A0A4X1VBD0
uniprot id: F2Z5C1
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9823:LOC100156793
gene id: 9823:LOC100156793
uniprot id: A0A8D1RE35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100519299
gene id: 9823:LOC100519299
uniprot id: A0A286ZQ83
uniprot id: A0A8D0PAJ7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100524254
gene id: 9823:LOC100524254
uniprot id: A0A8D0ZJL5
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9823:UIMC1
gene id: 9823:UIMC1
uniprot id: A0P8Z5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAP80 family.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1. Interacts with UBE2I. Interacts with NR6A1. Interacts with ESR1 (By similarity). Interacts with TSP57 (By similarity). Interacts with TRAIP (By similarity).
messages: Nucleus
messages: Phosphorylated upon DNA damage by ATM or ATR.
messages: Sumoylated.
messages: The Abraxas-interacting region (AIR) mediates the interaction with ABRAXAS1.
messages: The tandem UIM domains form a continuous 60 Angstrom-long alpha-helix and mediate binding to 'Lys-63'-linked ubiquitins. UIM1 and UIM2 bind to the proximal and distal ubiquitin moieties and recognize an 'Ile-44'-centered hydrophobic patch. Since UIMs don't interact with the 'Lys-63' isopeptide bond the UIM-linker region between the 2 UIM domains determines the selectivity for 'Lys-63'-linkage, and its length is very important for specificity.
messages: Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

9823:LOC100523452
gene id: 9823:LOC100523452
uniprot id: A0A4X1TJ43
uniprot id: F1S7F0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SPIN1
gene id: 9823:SPIN1
uniprot id: D3K5M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

9823:TERF1
gene id: 9823:TERF1
uniprot id: A0A286ZMS0
uniprot id: A0A287ALL2
uniprot id: A0A4X1UIZ8
uniprot id: A0A4X1UL63
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

9823:EWSR1
gene id: 9823:EWSR1
uniprot id: A0A4X1VEY0
uniprot id: A0A4X1VHL7
uniprot id: A0A8D0PSR4
uniprot id: G8ENL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9823:SV2A
gene id: 9823:SV2A
uniprot id: A0A4X1SJE0
uniprot id: F1SDF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9823:LOC100623656
gene id: 9823:LOC100623656
uniprot id: A0A4X1VUM5
uniprot id: I3L648
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:TSC22D1
gene id: 9823:TSC22D1
uniprot id: A0A480VYK0
uniprot id: A0A4X1SDK8
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9823:DBP
gene id: 9823:DBP
uniprot id: A0A4X1VUT2
uniprot id: F1RIP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9823:LOC100510917
gene id: 9823:LOC100510917
uniprot id: A0A4X1TGN8
uniprot id: I3LBL7
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9823:GCNT7
gene id: 9823:GCNT7
uniprot id: A5GFW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 14 family.
messages: Glycosyltransferase.
messages: Golgi apparatus membrane

9823:GREM2
gene id: 9823:GREM2
uniprot id: A0A4X1TI36
uniprot id: F1S9G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9823:LIMS2
gene id: 9823:LIMS2
uniprot id: A0A480W7H2
uniprot id: A0A4X1VR23
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9823:PIM2
gene id: 9823:PIM2
uniprot id: A0A4X1VJM5
uniprot id: I3L8X4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9823:TRIM72
gene id: 9823:TRIM72
uniprot id: A0A1W6R2B4
uniprot id: A0A4X1TGS5
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle membrane
messages: sarcolemma

9823:ABT1
gene id: 9823:ABT1
uniprot id: A0A287B3X6
uniprot id: A0A8D0LZW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

9823:NCBP2
gene id: 9823:NCBP2
uniprot id: A0A4X1TVZ8
uniprot id: F2Z5Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9823:PIP4K2A
gene id: 9823:PIP4K2A
uniprot id: O13010
names: Activity Regulation
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer. Interacts with PIP4K2B; the interaction may regulate localization to the nucleus (By similarity). Probably interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity (By similarity).
messages: In rod outer segments, activated by light.
messages: Lysosome
messages: Nucleus
messages: Phosphorylated in tyrosines. Phosphorylation is induced by light and increases kinase activity.
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9823:COX5B
gene id: 9823:COX5B
uniprot id: Q5S3G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5B family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9823:SYN1
gene id: 9823:SYN1
uniprot id: A0A4X1T9Y1
uniprot id: A0A8D2ABL6
uniprot id: B7TY10
uniprot id: B7TY11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synapsin family.
messages: Golgi apparatus
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: synaptic vesicle

9823:MRPS17
gene id: 9823:MRPS17
uniprot id: A0A8D1UDM1
uniprot id: F1RIU0
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9823:LOC100512568
gene id: 9823:LOC100512568
uniprot id: A0A8D1XG61
uniprot id: F1RR91
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9823:RAD51
gene id: 9823:RAD51
uniprot id: A0A4X1UVK9
uniprot id: B0M1M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9823:GABRA5
gene id: 9823:GABRA5
uniprot id: A0A286ZS36
uniprot id: A0A4X1UE24
uniprot id: A0A4X1UE43
uniprot id: A0A8D0RZL5
uniprot id: F1SR89
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:LOC100737531
gene id: 9823:LOC100737531
uniprot id: A0A4X1V7K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ITGB3
gene id: 9823:ITGB3
uniprot id: A0A4X1T8N7
uniprot id: Q95JH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9823:DNAL4
gene id: 9823:DNAL4
uniprot id: A4F4L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein light chain family.
messages: Consists of at least two heavy chains and a number of intermediate and light chains.
messages: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).
messages: cilium axoneme

9823:SLC31A1
gene id: 9823:SLC31A1
uniprot id: Q8WNR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Cell membrane
messages: High-affinity, saturable copper transporter involved in dietary copper uptake.
messages: Homotrimer.

9823:LOC100515562
gene id: 9823:LOC100515562
uniprot id: A0A286ZWN1
uniprot id: A0A8D1AFX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CYB561
gene id: 9823:CYB561
uniprot id: Q95245
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 2 heme b groups non-covalently.
messages: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes.
messages: chromaffin granule membrane

9823:MINPP1
gene id: 9823:MINPP1
uniprot id: A0A8D1WBH6
uniprot id: F1SCZ6
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

9823:GPRASP2
gene id: 9823:GPRASP2
uniprot id: A0A4X1VZ99
uniprot id: F1RYE7
names: Similarity
messages: Belongs to the GPRASP family.

9823:UGT1A6
gene id: 9823:UGT1A6
uniprot id: A0A481D317
uniprot id: A0A4X1TFL0
uniprot id: F1SM20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9823:UBE2C
gene id: 9823:UBE2C
uniprot id: A0A4X1U068
uniprot id: F1SC78
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:MOXD1
gene id: 9823:MOXD1
uniprot id: A0A8D1CCD9
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9823:ATG9A
gene id: 9823:ATG9A
uniprot id: A0A480SYV2
uniprot id: A0A8D0PA50
uniprot id: D7RA26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9823:DUSP27
gene id: 9823:DUSP27
uniprot id: A0A5K1V146
uniprot id: A0A8D1QFF7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9823:SMIM19
gene id: 9823:SMIM19
uniprot id: A0A287B4P4
uniprot id: A0A4X1U937
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9823:LIPT2
gene id: 9823:LIPT2
uniprot id: A0A4X1UQK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

9823:AFF2
gene id: 9823:AFF2
uniprot id: A0A480K3V4
uniprot id: A0A8D1A9C9
names: Similarity
messages: Belongs to the AF4 family.

9823:AMELY
gene id: 9823:AMELY
uniprot id: P45561
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: A number of other isoforms are produced by carboxy-terminal processing.
messages: Belongs to the amelogenin family.
messages: Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.
messages: extracellular matrix

9823:ATF7IP
gene id: 9823:ATF7IP
uniprot id: A0A286ZST1
uniprot id: A0A287A8A1
uniprot id: A0A4X1V8L9
uniprot id: A0A4X1V8N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9823:IL2RA
gene id: 9823:IL2RA
uniprot id: O02733
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9823:ADRB3
gene id: 9823:ADRB3
uniprot id: A0A8J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
messages: Cell membrane
messages: Interacts with ARRDC3.
messages: Membrane

9823:PEX16
gene id: 9823:PEX16
uniprot id: A0A480PCT8
uniprot id: A0A4X1SEG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9823:PMP2
gene id: 9823:PMP2
uniprot id: P86412
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol (By similarity).
messages: Monomer.
messages: P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.

9823:LAMP1
gene id: 9823:LAMP1
uniprot id: A0A8D1DTS3
uniprot id: Q5K4G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9823:LOC100736710
gene id: 9823:LOC100736710
uniprot id: F1SQC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TFIP11
gene id: 9823:TFIP11
uniprot id: A0A480XBS3
uniprot id: Q06AK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2 (By similarity).
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9823:IRF5
gene id: 9823:IRF5
uniprot id: K9J6J1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:SLC39A3
gene id: 9823:SLC39A3
uniprot id: A0A4X1VMY9
uniprot id: F1S8G7
names: Subcellular Location Annotation
messages: Membrane

9823:THAP1
gene id: 9823:THAP1
uniprot id: A0A287AAN9
uniprot id: A0A4X1UB65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9823:TOMM40L
gene id: 9823:TOMM40L
uniprot id: A0A8D1IS56
uniprot id: F1S1B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:LOC106504154
gene id: 9823:LOC106504154
uniprot id: Q5I921
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRY family.
messages: Cytoplasm
messages: Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its DNA-binding activity. The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form. Interaction with PARP1 impaired its DNA-binding activity.
messages: Nucleus speckle
messages: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.

9823:ITGA2B
gene id: 9823:ITGA2B
uniprot id: Q9TUN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9823:ACE
gene id: 9823:ACE
uniprot id: A0A480IQM9
uniprot id: A0A8D1QGW8
uniprot id: A0A8D1QK76
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.

9823:CFP
gene id: 9823:CFP
uniprot id: A0A5G2QHH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:ADAM2
gene id: 9823:ADAM2
uniprot id: A0A4X1VWX2
uniprot id: Q866A8
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with ADAM1/fertilin subunit alpha.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

9823:MLF2
gene id: 9823:MLF2
uniprot id: A0A4X1UTZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9823:GATA5
gene id: 9823:GATA5
uniprot id: A0A8D1QB79
names: Subcellular Location Annotation
messages: Nucleus

9823:SAE1
gene id: 9823:SAE1
uniprot id: A0A4X1W187
uniprot id: F1RM03
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9823:ACSL1
gene id: 9823:ACSL1
uniprot id: A0A287BMY7
uniprot id: A0A480QCC9
uniprot id: A0A4X1VRQ6
uniprot id: A0A4X1VWL0
uniprot id: Q6B339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9823:FAM208A
gene id: 9823:FAM208A
uniprot id: A0A287B2V7
uniprot id: A0A8D0WZE9
names: Similarity
messages: Belongs to the TASOR family.

9823:TMEM106A
gene id: 9823:TMEM106A
uniprot id: A0A480WV09
uniprot id: A0A480ZC76
uniprot id: A0A4X1TU65
uniprot id: A0A8D1GZV4
names: Similarity
messages: Belongs to the TMEM106 family.

9823:MRPL32
gene id: 9823:MRPL32
uniprot id: A0A287B1Q6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9823:ACMSD
gene id: 9823:ACMSD
uniprot id: A0A4X1SS84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9823:PALM
gene id: 9823:PALM
uniprot id: Q2MJV8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apicolateral cell membrane
messages: Basolateral cell membrane
messages: Belongs to the paralemmin family.
messages: Cell membrane
messages: Interacts with dopamine receptor DRD3.
messages: Involved in plasma membrane dynamics and cell process formation. Necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner (By similarity).
messages: Phosphorylated.
messages: axon
messages: dendrite
messages: dendritic spine
messages: filopodium membrane

9823:TM9SF3
gene id: 9823:TM9SF3
uniprot id: A0A4X1UB50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9823:FSHR
gene id: 9823:FSHR
uniprot id: A0A8D1R806
uniprot id: I3L9Z2
uniprot id: P49059
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (By similarity).
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation.
messages: Membrane
messages: N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.
messages: Sulfated.

9823:ABRA
gene id: 9823:ABRA
uniprot id: B5SNZ6
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
messages: Binds F-actin and ABLIM1, ABLIM2 and ABLIM3. Interaction with ABLIM2 and ABLIM3 enhances activity (By similarity).
messages: Expression increase gradually from 33 dpc (days post-coitum) to postnatal muscles, and peaks at 28 days postnatal.
messages: Specifically expressed in heart and skeletal muscles.
messages: The actin-binding domain 1 (ABD1) is intrinsically disordered, and binds to F-actin with higher affinity than ABD2.
messages: cytoskeleton
messages: sarcomere

9823:LOC100627234
gene id: 9823:LOC100627234
uniprot id: A0A287BB81
uniprot id: A0A8D0K8I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ZSCAN20
gene id: 9823:ZSCAN20
uniprot id: A0A8D1BHJ2
uniprot id: F1SV80
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9823:LOC100523964
gene id: 9823:LOC100523964
uniprot id: A0A4X1W9L8
uniprot id: F1SPJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9823:SLC35A5
gene id: 9823:SLC35A5
uniprot id: A0A8D0YQ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9823:ZDHHC7
gene id: 9823:ZDHHC7
uniprot id: A0A4X1T3L7
uniprot id: F1S5W3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:RPS6KA3
gene id: 9823:RPS6KA3
uniprot id: A0A4X1VBK6
uniprot id: F1SQN4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9823:SLC25A31
gene id: 9823:SLC25A31
uniprot id: F1RRA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9823:RPL26
gene id: 9823:RPL26
uniprot id: A0A4X1V977
uniprot id: I3L7Y1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9823:RRM2B
gene id: 9823:RRM2B
uniprot id: A0A480TJS0
uniprot id: A0A4X1TTB9
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

9823:SFXN1
gene id: 9823:SFXN1
uniprot id: A5A761
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine.
messages: Belongs to the sideroflexin family.
messages: Mitochondrion inner membrane

9823:LOC100513601
gene id: 9823:LOC100513601
uniprot id: D6C4F8
uniprot id: F1S1N1
names: Similarity
messages: Belongs to the MHC class I family.

9823:KCNA2
gene id: 9823:KCNA2
uniprot id: A0A4X1TD15
uniprot id: Q1AP78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

9823:AMER1
gene id: 9823:AMER1
uniprot id: A0A4X1VHL9
uniprot id: A0A5K1UCI1
names: Similarity
messages: Belongs to the Amer family.

9823:KRT3
gene id: 9823:KRT3
uniprot id: A0A5G2QSE8
names: Similarity
messages: Belongs to the intermediate filament family.

9823:MAS1
gene id: 9823:MAS1
uniprot id: A0A480DGN1
uniprot id: A0A4X1VX06
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:AKAP8
gene id: 9823:AKAP8
uniprot id: A0A8D1AXB0
names: Similarity
messages: Belongs to the AKAP95 family.

9823:FGD1
gene id: 9823:FGD1
uniprot id: A0A8D0SVY8
uniprot id: F1RUG2
names: Subcellular Location Annotation
messages: cytoskeleton

9823:GPC4
gene id: 9823:GPC4
uniprot id: A0A4X1WA83
uniprot id: F1RTE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9823:KCNB1
gene id: 9823:KCNB1
uniprot id: O18868
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Acetylation occurs in pancreatic beta cells in response to stimulation by incretin hormones in a histone acetyltransferase (HAT)/histone deacetylase (HDAC)-dependent signaling pathway, promoting beta cell survival.
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Cell membrane
messages: Homotetramer or heterotetramer with KCNB2. Heterotetramer with non-conducting channel-forming alpha subunits such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1. Channel activity is regulated by association with ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3. Self-associates (via N-terminus and C-terminus); self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel. Interacts (via C-terminus) with STX1A (via C-terminus); this decreases the rate of channel activation and increases the rate of channel inactivation in pancreatic beta cells, induces also neuronal apoptosis in response to oxidative injury as well as pore-independent enhancement of exocytosis in neuroendocrine cells, chromaffin cells, pancreatic beta cells and from the soma of dorsal root ganglia (DRG) neurons. Interacts (via N-terminus) with SNAP25; this decreases the rate of channel inactivation in pancreatic beta cells and also increases interaction during neuronal apoptosis in a N-methyl-D-aspartate receptor (NMDAR)-dependent manner. Interacts (via N-terminus and C-terminus) with VAMP2 (via N-terminus); stimulates channel inactivation rate. Interacts with CREB1; this promotes channel acetylation in response to stimulation by incretin hormones. Interacts (via N-terminus and C-terminus) with MYL12B. Interacts (via N-terminus) with PIAS3; this increases the number of functional channels at the cell surface. Interacts with SUMO1. Interacts (via phosphorylated form) with PTPRE; this reduces phosphorylation and channel activity in heterologous cells.
messages: Inhibited by 12.7 nM stromatoxin 1 (ScTx1), a spider venom toxin of the tarantula S.calceata. Inhibited by 42 nM hanatoxin 1 (HaTx1), a spider venom toxin of the tarantula G.spatulata. Modestly sensitive to millimolar levels of tetraethylammonium (TEA). Modestly sensitive to millimolar levels of 4-aminopyridine (4-AP). Completely insensitive to toxins such as dendrotoxin (DTX) and charybdotoxin (CTX).
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Phosphorylated. Differential C-terminal phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating in hippocampal neurons. Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/dephosphorylation activities. Tyr-128 can be phosphorylated by Src and dephosphorylated by cytoplasmic form of the phosphatase PTPRE. CDK5-induced Ser-607 phosphorylation increases in response to acute blockade of neuronal activity. Phosphorylated on Tyr-128 by Src and on Ser-805 by MAPK14/P38MAPK; phosphorylations are necessary and sufficient for an increase in plasma membrane insertion, apoptotic potassium current surge and completion of the neuronal cell death program. Phosphorylated on Ser-520, Ser-607, Ser-656 and Ser-805 by CDK5; phosphorylation is necessary for KCNB1 channel clustering formation. The Ser-607 phosphorylation state differs between KCNB1-containing clusters on the proximal and distal portions of the axon initial segment (AIS). Highly phosphorylated on serine residues in the C-terminal cytoplasmic tail in resting neurons. Phosphorylated in pancreatic beta cells in response to incretin hormones stimulation in a PKA- and RPS6KA5/MSK1-dependent signaling pathway, promoting beta cell survival. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5; levels then increase to reach adult levels by P14. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are sensitive to calcineurin-mediated dephosphorylation contributing to the modulation of the voltage-dependent gating properties. Dephosphorylation by phosphatase PTPRE confers neuroprotection by its inhibitory influence on the neuronal apoptotic potassium current surge in a Zn(2+)-dependent manner. Dephosphorylated at Ser-607 by protein phosphatase PPP1CA. Hypoxia-, seizure- or glutamate-induced neuronal activity promote calcium/calcineurin-dependent dep…
messages: Postsynaptic cell membrane
messages: Sumoylated on Lys-475, preferentially with SUMO1; sumoylation induces a positive shift in the voltage-dependence of activation and inhibits channel activity. Sumoylation increases the frequency of repetitive action potential firing at the cell surface of hippocampal neurons and decreases its frequency in pancreatic beta cells. Desumoylated by SENP1.
messages: Synapse
messages: The N-terminal and C-terminal cytoplasmic regions mediate homooligomerization; self-association is required to regulate trafficking, gating and C-terminal phosphorylation-dependent modulation of the channel. The N-terminal cytoplasmic region is important for interaction with other channel-forming alpha subunits and with ancillary beta subunits. The C-terminus is necessary and sufficient for the restricted localization to, and clustering within, both in soma and proximal portions of dendrite of neurons and in lateral membrane of non-neuronal polarized cells. The C-terminus is both necessary and sufficient as a mediator of cholinergic and calcium-stimulated modulation of channel cell membrane clustering localization and activity in hippocampal neurons.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Also plays a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (By similarity). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Channel properties are also modulated by cytoplasmic ancillary beta subunits, such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assig…
messages: axon
messages: dendrite
messages: sarcolemma
messages: synaptosome

9823:SYNGR1
gene id: 9823:SYNGR1
uniprot id: A0A4X1VUI9
uniprot id: I3LLM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9823:COX17
gene id: 9823:COX17
uniprot id: A0A4X1T3X0
uniprot id: D2XUP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9823:AIF1
gene id: 9823:AIF1
uniprot id: A0A4X1VFT5
uniprot id: A0A8D0PI58
uniprot id: A5D9N3
uniprot id: Q9GK84
names: Subcellular Location Annotation
messages: ruffle membrane

9823:RPS17
gene id: 9823:RPS17
uniprot id: Q6QAP7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9823:ABHD2
gene id: 9823:ABHD2
uniprot id: A0A286ZYT1
uniprot id: A0A4X1U5A9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9823:TCF19
gene id: 9823:TCF19
uniprot id: Q9TSV4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

9823:HPCAL4
gene id: 9823:HPCAL4
uniprot id: A0A4X1VW14
uniprot id: A0A5K1VBW2
uniprot id: Q06AS4
names: Function
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

9823:EMP1
gene id: 9823:EMP1
uniprot id: A6N1V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9823:DOK4
gene id: 9823:DOK4
uniprot id: A0A480SYL8
uniprot id: A0A4X1UYW0
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9823:LOC100738112
gene id: 9823:LOC100738112
uniprot id: A0A8D1QGR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PPP1R14D
gene id: 9823:PPP1R14D
uniprot id: A0A4X1UR88
uniprot id: A0A8D0R085
uniprot id: F1SST3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9823:TMEM150C
gene id: 9823:TMEM150C
uniprot id: A0A480YWH4
uniprot id: A0A4X1TDF9
uniprot id: A0A4X1TDG4
uniprot id: I3L597
names: Subcellular Location Annotation
messages: Membrane

9823:POLR1B
gene id: 9823:POLR1B
uniprot id: A0A480EKA2
uniprot id: A0A4X1V7F6
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9823:SLA-DMA
gene id: 9823:SLA-DMA
uniprot id: A0A4X1V162
uniprot id: Q9BEA4
names: Similarity
messages: Belongs to the MHC class II family.

9823:DLAT
gene id: 9823:DLAT
uniprot id: Q95N04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9823:MTCH1
gene id: 9823:MTCH1
uniprot id: A0A8D1Q830
uniprot id: F1RVS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:MRPS33
gene id: 9823:MRPS33
uniprot id: A0A287AAU7
uniprot id: A0A4X1V7Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9823:NEIL3
gene id: 9823:NEIL3
uniprot id: A0A287BGY1
uniprot id: A0A4X1VS65
uniprot id: A0A4X1VX30
uniprot id: F1RT18
names: Similarity
messages: Belongs to the FPG family.

9823:RPRM
gene id: 9823:RPRM
uniprot id: A0A287BPY9
uniprot id: A0A4X1VRB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Cytoplasm
messages: Membrane

9823:SPPL2B
gene id: 9823:SPPL2B
uniprot id: A0A287BCL8
uniprot id: A0A480EN37
uniprot id: A0A4X1VN26
uniprot id: A0A8D1E4T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9823:PNRC2
gene id: 9823:PNRC2
uniprot id: A0A4X1VXM2
uniprot id: I3LST4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Nucleus
messages: P-body

9823:LOC100510930
gene id: 9823:LOC100510930
uniprot id: A0A8D0MRN3
uniprot id: F1RK98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9823:RAB32
gene id: 9823:RAB32
uniprot id: Q06AU5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Interacts with ANKRD27. A decreased interaction with ANKRD27 seen in the presence of SGSM2 (By similarity).
messages: Melanosome
messages: Melanosome membrane
messages: Mitochondrion
messages: Mitochondrion outer membrane
messages: Regulated by a guanine nucleotide-exchange factor (GEF) and a GTPase-activating protein (GAP) and alternates between an inactive GDP-bound and an active GTP-bound form. The BLOC-3 complex composed of HPS1 and HPS4 acts as its GEF, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. SGSM2 acts as its GAP and inactivates it by stimulating its GTPase activity.
messages: phagosome
messages: phagosome membrane

9823:AMZ1
gene id: 9823:AMZ1
uniprot id: A0A4X1TKR9
uniprot id: D3K5N1
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9823:MFAP1
gene id: 9823:MFAP1
uniprot id: A0A287AJC7
uniprot id: A0A4X1VC88
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9823:TMEM134
gene id: 9823:TMEM134
uniprot id: A0A8D1GJR2
uniprot id: F1RUZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

9823:LOC100737265
gene id: 9823:LOC100737265
uniprot id: A0A287BKM7
uniprot id: A0A4X1U4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9823:ZSCAN23
gene id: 9823:ZSCAN23
uniprot id: A0A4X1VKI8
uniprot id: A0A8D0W5G6
names: Subcellular Location Annotation
messages: Nucleus

9823:CDC42SE2
gene id: 9823:CDC42SE2
uniprot id: A0A287ABZ0
uniprot id: A0A4X1UMB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9823:LOC100525311
gene id: 9823:LOC100525311
uniprot id: A0A287A3F2
uniprot id: A0A4X1TGD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9823:KCNG1
gene id: 9823:KCNG1
uniprot id: A0A4X1UL71
uniprot id: A5GFZ3
names: Subcellular Location Annotation
messages: Membrane

9823:ALX1
gene id: 9823:ALX1
uniprot id: A0A287AYX1
uniprot id: A0A8D1B4G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9823:GGT6
gene id: 9823:GGT6
uniprot id: A0A8D0WIB5
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9823:IDH1
gene id: 9823:IDH1
uniprot id: A0A4X1UZU9
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9823:SEC23A
gene id: 9823:SEC23A
uniprot id: A0A4X1TF27
uniprot id: F1SHL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9823:RPL5
gene id: 9823:RPL5
uniprot id: B0FWK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9823:SLC22A5
gene id: 9823:SLC22A5
uniprot id: A0A286ZXK3
uniprot id: A0A8D0NE01
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9823:DBNDD1
gene id: 9823:DBNDD1
uniprot id: A0A8D0RIG3
names: Similarity
messages: Belongs to the dysbindin family.

9823:RPL22L1
gene id: 9823:RPL22L1
uniprot id: A0A4X1V8X4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9823:UCK1
gene id: 9823:UCK1
uniprot id: A0A4X1T9P1
uniprot id: A0A5G2R1J1
uniprot id: A0A8D1UXN6
uniprot id: F1S0W2
names: Similarity
messages: Belongs to the uridine kinase family.

9823:BPIFA1
gene id: 9823:BPIFA1
uniprot id: A0A8D1D3G3
uniprot id: K7GS01
uniprot id: Q5XW65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
messages: Expressed in lung and trachea.
messages: Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils.
messages: Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC (By similarity).
messages: Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.
messages: Reported to bind to bacterial lipopolysaccharide (LPS) in vitro. However, the in vivo significance of this is uncertain since other studies indicate little or no specificity for LPS.
messages: Secreted

9823:EGFL8
gene id: 9823:EGFL8
uniprot id: A5A8Y8
uniprot id: B9TSS1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:SEMA4F
gene id: 9823:SEMA4F
uniprot id: A0A287AF71
uniprot id: A0A287BS05
uniprot id: A0A4X1W6S8
uniprot id: A0A4X1W863
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:KLHL40
gene id: 9823:KLHL40
uniprot id: A0A4X1TK38
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

9823:CD27
gene id: 9823:CD27
uniprot id: A0A4X1UUI8
uniprot id: F1SL30
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CST6
gene id: 9823:CST6
uniprot id: A0A4X1UDP8
uniprot id: F1RU34
names: Subcellular Location Annotation
messages: Cytoplasm

9823:LOC100518623
gene id: 9823:LOC100518623
uniprot id: A0A4X1SHH2
uniprot id: A0A5G2QFL3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CCL21
gene id: 9823:CCL21
uniprot id: Q6EKW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:VAMP2
gene id: 9823:VAMP2
uniprot id: A0A4X1VAA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane

9823:LXN
gene id: 9823:LXN
uniprot id: A0A4X1SH17
uniprot id: I3LN84
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9823:SETD3
gene id: 9823:SETD3
uniprot id: A0A4X1TJH9
uniprot id: A0A5K1UVT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Interacts with MYOD1.

9823:ARRDC2
gene id: 9823:ARRDC2
uniprot id: A0A287AMQ8
uniprot id: A0A4X1UBD4
uniprot id: A0A8D1RZJ8
uniprot id: F1S922
names: Similarity
messages: Belongs to the arrestin family.

9823:LOC100525099
gene id: 9823:LOC100525099
uniprot id: A0A480EIC9
uniprot id: A0A4X1TZY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

9823:CDKN1B
gene id: 9823:CDKN1B
uniprot id: A0A4X1V4V1
uniprot id: Q9BDC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

9823:LOC100514452
gene id: 9823:LOC100514452
uniprot id: A0A4X1TUQ8
uniprot id: I3LJF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ELL3
gene id: 9823:ELL3
uniprot id: A0A480EEG8
uniprot id: A0A4X1VBU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9823:SERPINA7
gene id: 9823:SERPINA7
uniprot id: Q9TT35
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Expressed by the liver and secreted in plasma.
messages: Major thyroid hormone transport protein in serum.
messages: Secreted
messages: The allele with Asn-245 has a significantly greater affinity for thyroxine than the His-245 allele found in Meishan boars. This polymorphism is a candidate for the causative variation affecting testis size in boars.

9823:TRAPPC4
gene id: 9823:TRAPPC4
uniprot id: A0A4X1SKI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9823:RPS12
gene id: 9823:RPS12
uniprot id: A0A480QPE7
uniprot id: P46405
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS12 family.
messages: Cytoplasm

9823:PIGH
gene id: 9823:PIGH
uniprot id: A0A481AC83
uniprot id: A0A4X1U3F7
uniprot id: A0A8D0P9T4
names: Similarity
messages: Belongs to the PIGH family.

9823:TBX5
gene id: 9823:TBX5
uniprot id: A0A4X1TJK0
uniprot id: F1RKD2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:SRXN1
gene id: 9823:SRXN1
uniprot id: A0A8D1VMI3
names: Similarity
messages: Belongs to the sulfiredoxin family.

9823:COPS3
gene id: 9823:COPS3
uniprot id: A0A480PTM7
uniprot id: A0A4X1SRI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN3 family.
messages: Cytoplasm
messages: Nucleus

9823:WNT10B
gene id: 9823:WNT10B
uniprot id: U5XKA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:AGXT2
gene id: 9823:AGXT2
uniprot id: A0A8D0PY34
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9823:CD180
gene id: 9823:CD180
uniprot id: A0A4X1UM95
uniprot id: Q7YRL4
names: Similarity
messages: Belongs to the Toll-like receptor family.

9823:IFI44L
gene id: 9823:IFI44L
uniprot id: A0A8D1B5X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI44 family.
messages: Cytoplasm

9823:CYP2E1
gene id: 9823:CYP2E1
uniprot id: P79383
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9823:HCN3
gene id: 9823:HCN3
uniprot id: A0A4X1VZD0
uniprot id: F1RLJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9823:HTR2B
gene id: 9823:HTR2B
uniprot id: A0A4X1THR3
uniprot id: F1SMV8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via C-terminus) with MPDZ.
messages: Membrane
messages: synaptosome

9823:PTH1R
gene id: 9823:PTH1R
uniprot id: A0A480JVN1
uniprot id: P50133
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8688470). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

9823:CPB1
gene id: 9823:CPB1
uniprot id: P09955
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Secreted
messages: Zymogen granule lumen

9823:SLC19A3
gene id: 9823:SLC19A3
uniprot id: A0A8D0Z7H4
uniprot id: I3LRJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

9823:ADNP
gene id: 9823:ADNP
uniprot id: A0A286ZTL6
uniprot id: A0A4X1UH91
uniprot id: A0A4X1UJE1
uniprot id: A5GHK7
names: Subcellular Location Annotation
messages: Nucleus

9823:C1H15orf65
gene id: 9823:C1H15orf65
uniprot id: A0A287AA69
uniprot id: A0A4X1TH04
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9823:SMAD7
gene id: 9823:SMAD7
uniprot id: A0A287ASU5
uniprot id: A0A4X1UKJ4
uniprot id: A0A4X1UM82
uniprot id: A0A8D1CF02
uniprot id: F1CK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9823:CRY1
gene id: 9823:CRY1
uniprot id: A0A480LD13
uniprot id: A0A4X1SJC5
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9823:OXT
gene id: 9823:OXT
uniprot id: P01177
names: Function
names: Similarity
names: Subunit
messages: Belongs to the vasopressin/oxytocin family.
messages: Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).
messages: Neurophysin 1 specifically binds oxytocin.
messages: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity).

9823:LOC100523054
gene id: 9823:LOC100523054
uniprot id: A0A287AHG6
uniprot id: A0A8D0RXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:ADAM19
gene id: 9823:ADAM19
uniprot id: A0A8D1I4L9
uniprot id: F1RQF1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LOC100737613
gene id: 9823:LOC100737613
uniprot id: A0A4X1TWI5
uniprot id: F1S6N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ME1
gene id: 9823:ME1
uniprot id: A0A4X1V1B8
uniprot id: A0A5G2RAJ8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9823:S100A10
gene id: 9823:S100A10
uniprot id: A0A4X1W024
uniprot id: F2Z5M2
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9823:STRIP1
gene id: 9823:STRIP1
uniprot id: A0A4X1TD37
uniprot id: F1S614
names: Similarity
messages: Belongs to the STRIP family.

9823:SQLE
gene id: 9823:SQLE
uniprot id: A0A8D1HQ11
uniprot id: A7L861
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9823:PSMD9
gene id: 9823:PSMD9
uniprot id: A0A286ZLP7
uniprot id: A0A4X1UAE8
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9823:IL4I1
gene id: 9823:IL4I1
uniprot id: A0A287APE6
uniprot id: A0A287BPT0
uniprot id: A0A4X1VWF2
uniprot id: A0A4X1VYN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

9823:VKORC1L1
gene id: 9823:VKORC1L1
uniprot id: A0A4X1SYC2
uniprot id: A0A5K1VIT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC100624648
gene id: 9823:LOC100624648
uniprot id: A0A4X1TYS3
uniprot id: K7GP27
names: Similarity
messages: Belongs to the WD repeat EBI family.

9823:LOC100738720
gene id: 9823:LOC100738720
uniprot id: A0A286ZKC0
uniprot id: A0A8D1H255
names: Subcellular Location Annotation
messages: Membrane

9823:DNAJA2
gene id: 9823:DNAJA2
uniprot id: A0A4X1TXQ3
uniprot id: F1RP05
names: Subcellular Location Annotation
messages: Membrane

9823:CD81
gene id: 9823:CD81
uniprot id: Q007T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:MGP
gene id: 9823:MGP
uniprot id: D3Y2W1
uniprot id: Q8MJ39
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9823:SCFD2
gene id: 9823:SCFD2
uniprot id: A0A4X1U9Q4
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9823:MRPS11
gene id: 9823:MRPS11
uniprot id: A0A286ZJJ6
uniprot id: A0A4X1WCN2
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9823:DST
gene id: 9823:DST
uniprot id: A0A287A0I5
names: Subcellular Location Annotation
messages: cytoskeleton

9823:B3GAT1
gene id: 9823:B3GAT1
uniprot id: A0A286ZTI9
uniprot id: A0A8D1MS48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:DCN
gene id: 9823:DCN
uniprot id: Q9XSD9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).
messages: May affect the rate of fibrils formation.
messages: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
messages: extracellular matrix

9823:GBF1
gene id: 9823:GBF1
uniprot id: A0A480X8U4
uniprot id: A0A8D0TLB1
names: Subcellular Location Annotation
messages: Golgi apparatus

9823:HPCAL1
gene id: 9823:HPCAL1
uniprot id: Q06AT0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
messages: Membrane
messages: Probably binds two or three calcium ions.

9823:DDX58
gene id: 9823:DDX58
uniprot id: B9WZD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9823:LOC100525476
gene id: 9823:LOC100525476
uniprot id: A0A5G2QVW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:YWHAH
gene id: 9823:YWHAH
uniprot id: A0A4X1V4V6
uniprot id: F2Z4Y1
names: Similarity
messages: Belongs to the 14-3-3 family.

9823:GAS6
gene id: 9823:GAS6
uniprot id: M1TFP4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:YIF1A
gene id: 9823:YIF1A
uniprot id: A0A286ZZB6
uniprot id: A0A4X1TTT0
uniprot id: A0A4X1TTW2
uniprot id: F1RU41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:CAV2
gene id: 9823:CAV2
uniprot id: Q2QLE2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
messages: Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).
messages: caveola

9823:PLA2G4A
gene id: 9823:PLA2G4A
uniprot id: A0A287AQ26
uniprot id: A0A4X1TRG4
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9823:ADAMTS13
gene id: 9823:ADAMTS13
uniprot id: A0A4X1SZQ6
uniprot id: A0A4X1T118
uniprot id: I3LKV5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:PSMD2
gene id: 9823:PSMD2
uniprot id: A0A480JRT9
uniprot id: A0A8D1WG70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9823:GOSR1
gene id: 9823:GOSR1
uniprot id: A0A286ZK62
uniprot id: A0A4X1U194
uniprot id: A0A8D0P3W6
uniprot id: F1RN67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9823:ZNF496
gene id: 9823:ZNF496
uniprot id: A0A4X1TWT2
uniprot id: A0A5G2QNP2
names: Subcellular Location Annotation
messages: Nucleus

9823:TMEM200B
gene id: 9823:TMEM200B
uniprot id: A0A4X1SX25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9823:TLR5
gene id: 9823:TLR5
uniprot id: A0A8D0LVU9
uniprot id: C0L925
uniprot id: Q59HI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9823:RAD9A
gene id: 9823:RAD9A
uniprot id: A0A8D1P0F0
names: Similarity
messages: Belongs to the rad9 family.

9823:S1PR3
gene id: 9823:S1PR3
uniprot id: A0A4X1SGB4
uniprot id: F1RN19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9823:ACKR3
gene id: 9823:ACKR3
uniprot id: A0A4X1T9Z1
uniprot id: F1SM08
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:MANBAL
gene id: 9823:MANBAL
uniprot id: A0A8D0K6E2
uniprot id: I3L5E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9823:PLAA
gene id: 9823:PLAA
uniprot id: A0A4X1WDK2
uniprot id: A0A5G2R0I9
uniprot id: A0A5G2R9S8
uniprot id: A0A8D1F343
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9823:LOC102162486
gene id: 9823:LOC102162486
uniprot id: A0A480YA88
uniprot id: A0A4X1V4S9
uniprot id: A0A4X1V4T9
uniprot id: A0A4X1V930
uniprot id: A0A4X1V960
uniprot id: A0A5G2QA69
names: Similarity
messages: Belongs to the Luc7 family.

9823:EFNA4
gene id: 9823:EFNA4
uniprot id: A0A286ZW63
uniprot id: A0A4X1W227
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:TBL1XR1
gene id: 9823:TBL1XR1
uniprot id: A0A4X1V1Q3
uniprot id: F1SGD0
names: Similarity
messages: Belongs to the WD repeat EBI family.

9823:SLCO1B3
gene id: 9823:SLCO1B3
uniprot id: A0A4X1VA05
uniprot id: A0A5K1VT10
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:MMP13
gene id: 9823:MMP13
uniprot id: A0A481A6Z6
uniprot id: A0A4X1TQT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
messages: Secreted

9823:PFDN4
gene id: 9823:PFDN4
uniprot id: A0A4X1UNU8
uniprot id: A5GHK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9823:LOC100152848
gene id: 9823:LOC100152848
uniprot id: A0A4X1VXG0
uniprot id: F1RNC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:XPC
gene id: 9823:XPC
uniprot id: A0A4X1U8S8
uniprot id: F1SPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

9823:BCL2L14
gene id: 9823:BCL2L14
uniprot id: G3M5H3
names: Similarity
messages: Belongs to the Bcl-2 family.

9823:LRP10
gene id: 9823:LRP10
uniprot id: B8XY20
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:REXO4
gene id: 9823:REXO4
uniprot id: A0A4X1SZW9
uniprot id: I3L751
names: Similarity
messages: Belongs to the REXO4 family.

9823:LOC100737113
gene id: 9823:LOC100737113
uniprot id: A0A8D0U4A9
names: Similarity
messages: Belongs to the intermediate filament family.

9823:DGKK
gene id: 9823:DGKK
uniprot id: F1RW19
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9823:ICMT
gene id: 9823:ICMT
uniprot id: A0A481C9N4
uniprot id: A0A4X1W840
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:HMBOX1
gene id: 9823:HMBOX1
uniprot id: A0A287AMR0
uniprot id: A0A4X1VB68
uniprot id: A0A4X1VB75
uniprot id: A0A8D0RZA0
uniprot id: A0A8D1BW61
uniprot id: F1RJQ0
names: Subcellular Location Annotation
messages: Nucleus

9823:EED
gene id: 9823:EED
uniprot id: A0A287B4M4
uniprot id: A0A4X1U5N3
uniprot id: A0A4X1U5Q1
uniprot id: F1STS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

9823:HAT1
gene id: 9823:HAT1
uniprot id: A0A480SKM4
uniprot id: A0A4X1V891
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9823:PTMA
gene id: 9823:PTMA
uniprot id: A0A4X1TDP1
uniprot id: C3VVV8
names: Similarity
messages: Belongs to the pro/parathymosin family.

9823:QTRT2
gene id: 9823:QTRT2
uniprot id: A0A481CD28
uniprot id: A0A4X1SX99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9823:FAM129A
gene id: 9823:FAM129A
uniprot id: A0A4X1TW79
uniprot id: K7GRN9
names: Similarity
messages: Belongs to the Niban family.

9823:FAM133B
gene id: 9823:FAM133B
uniprot id: A0A480JGJ3
uniprot id: A0A4X1U0P4
names: Similarity
messages: Belongs to the FAM133 family.

9823:ADIG
gene id: 9823:ADIG
uniprot id: Q30C86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adipogenin family.
messages: Membrane
messages: Nucleus
messages: Plays a role in stimulating adipocyte differentiation and development.

9823:AKR1B1
gene id: 9823:AKR1B1
uniprot id: A0A4X1VTL4
uniprot id: P80276
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls).
messages: Cytoplasm
messages: Monomer.

9823:SMARCD2
gene id: 9823:SMARCD2
uniprot id: A0A4X1T1C6
uniprot id: M3VH55
names: Similarity
messages: Belongs to the SMARCD family.

9823:CLU
gene id: 9823:CLU
uniprot id: Q29549
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 and PON1. Interacts with the complement complex. Interacts (via alpha chain) with XRCC6. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not interact with BAX in unstressed cells. Found in a complex with LTF, CLU, EPPIN and SEMG1. Interacts (immaturely glycosylated pre-secreted form) with HSPA5; this interaction promotes CLU stability and facilitates stress-induced CLU retrotranslocation from the secretory pathway to the mitochondria, thereby reducing stress-induced apoptosis by stabilizing mitochondrial membrane integrity. Interacts with BCL2L1; this interaction releases and activates BAX and promotes cell death. Interacts with TGFBR2 and ACVR1 (By similarity). Interacts (secreted form) with STMN3; this interaction may act as an important modulator during neuronal differentiation (By similarity). Interacts with VLDLR and LRP8 (By similarity).
messages: Belongs to the clusterin family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity).
messages: Heavily N-glycosylated. About 30% of the protein mass is comprised of complex N-linked carbohydrate. Endoplasmic reticulum (ER) stress induces changes in glycosylation status and increases level of hypoglycosylated forms. Core carbohydrates are essential for chaperone activity. Non-secreted forms are hypoglycosylated or unglycosylated.
messages: Highest levels in brain and liver; lower levels are detected in other tissues, including the aorta. Abundant in senescent porcine pituitary colloids.
messages: Microsome
messages: Mitochondrion
messages: Mitochondrion membrane
messages: Nucleus
messages: Polyubiquitinated, leading to proteasomal degradation. Under cellular stress, the intracellular level of cleaved form is reduced due to proteasomal degradation.
messages: Proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen. Proteolytic cleavage is not necessary for its chaperone activity. All non-secreted forms are not proteolytically cleaved. Chaperone activity of uncleaved forms is dependent on a non-reducing envoronment.
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9823:MLH1
gene id: 9823:MLH1
uniprot id: D3K5L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9823:IFT46
gene id: 9823:IFT46
uniprot id: A0A480U4I5
uniprot id: A0A4X1SPN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9823:HEPHL1
gene id: 9823:HEPHL1
uniprot id: I3LGG0
names: Similarity
messages: Belongs to the multicopper oxidase family.

9823:PSMB4
gene id: 9823:PSMB4
uniprot id: A0A287B088
uniprot id: A0A4X1W0Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9823:IFN-DELTA-7
gene id: 9823:IFN-DELTA-7
uniprot id: A0A4X1W6K1
uniprot id: C8CKB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:HS3ST3B1
gene id: 9823:HS3ST3B1
uniprot id: A0A8D0RV86
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:EEF2
gene id: 9823:EEF2
uniprot id: A0A287AWI9
uniprot id: A0A4X1VST4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

9823:ZNRD1
gene id: 9823:ZNRD1
uniprot id: A0A8D1SHH1
uniprot id: B6ICU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

9823:HSF5
gene id: 9823:HSF5
uniprot id: A0A8D1W7P6
uniprot id: I3LFB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9823:CCDC43
gene id: 9823:CCDC43
uniprot id: A0A480TVB8
uniprot id: A0A4X1THW7
names: Similarity
messages: Belongs to the CCDC43 family.

9823:CIAPIN1
gene id: 9823:CIAPIN1
uniprot id: A0A8D0K9J6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9823:PTPN4
gene id: 9823:PTPN4
uniprot id: A0A8D0HUI4
uniprot id: F1RXW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9823:DUOXA2
gene id: 9823:DUOXA2
uniprot id: A0A8D0M8J7
uniprot id: F1SN41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9823:NR3C2
gene id: 9823:NR3C2
uniprot id: A0A8D1SP41
uniprot id: K7GP51
names: Subcellular Location Annotation
messages: Nucleus

9823:DAZL
gene id: 9823:DAZL
uniprot id: A0A1B2TT46
uniprot id: A0A4X1UPF4
names: Subcellular Location Annotation
messages: Cytoplasm

9823:ZDHHC8
gene id: 9823:ZDHHC8
uniprot id: A0A480WNM2
uniprot id: A0A4X1UQJ5
uniprot id: A0A8D1CFG5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:IP6K3
gene id: 9823:IP6K3
uniprot id: A0A286ZTI7
uniprot id: A0A8D0U3U2
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9823:PPAG3
gene id: 9823:PPAG3
uniprot id: Q9BGG5
names: Similarity
messages: Belongs to the peptidase A1 family.

9823:IRF6
gene id: 9823:IRF6
uniprot id: A0A4X1TG90
uniprot id: E9LK28
uniprot id: Q8WNQ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:MPG
gene id: 9823:MPG
uniprot id: A0A287A8J6
uniprot id: A0A8D2CD68
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

9823:LOC100521433
gene id: 9823:LOC100521433
uniprot id: A0A4X1U0G5
uniprot id: A0A5G2R1Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:HSPB2
gene id: 9823:HSPB2
uniprot id: A0A480KM31
uniprot id: A0A4X1TBV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9823:TMEM14A
gene id: 9823:TMEM14A
uniprot id: A0A480JHW3
uniprot id: P56984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM14 family.
messages: Endoplasmic reticulum membrane
messages: Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
messages: Mitochondrion membrane

9823:ACO2
gene id: 9823:ACO2
uniprot id: P16276
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Binding of a [3Fe-4S] cluster leads to an inactive enzyme.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.
messages: Mitochondrion
messages: Monomer.

9823:SLC25A53
gene id: 9823:SLC25A53
uniprot id: A0A4X1W591
uniprot id: F1RYB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:DUSP4
gene id: 9823:DUSP4
uniprot id: A0A4X1VTP4
uniprot id: F1RX60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9823:FAM105A
gene id: 9823:FAM105A
uniprot id: A0A287AVS5
uniprot id: A0A4X1TLI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9823:CLN3
gene id: 9823:CLN3
uniprot id: A9UHP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

9823:ENTPD7
gene id: 9823:ENTPD7
uniprot id: A0A8D1LB91
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9823:IL12B
gene id: 9823:IL12B
uniprot id: Q28938
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Secreted

9823:CLDN19
gene id: 9823:CLDN19
uniprot id: A0A4X1W7E7
uniprot id: C3VMW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:GDF15
gene id: 9823:GDF15
uniprot id: A0A4X1U9F3
uniprot id: D3Y269
names: Similarity
messages: Belongs to the TGF-beta family.

9823:NSF
gene id: 9823:NSF
uniprot id: A0A287AYL9
uniprot id: A0A4X1TAC2
uniprot id: A0A4X1TE64
uniprot id: A0A8D1JA75
uniprot id: F1RRS3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9823:TULP3
gene id: 9823:TULP3
uniprot id: A0A287BTI9
uniprot id: A0A480JWW4
uniprot id: A0A4X1UKF7
uniprot id: A0A4X1UM45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9823:SLC22A6
gene id: 9823:SLC22A6
uniprot id: Q8MK48
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Glycosylated. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane (By similarity).
messages: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (By similarity). Also mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate. Mediates the sodium-independent uptake of p-aminohippurate (PAH). PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity). PAH uptake is inhibited by probenecid and alpha-ketoglutarate.
messages: Multiple cysteine residues are necessary for proper targeting to the plasma membrane.

9823:SAR1A
gene id: 9823:SAR1A
uniprot id: Q52NJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Interacts with B3GAT1.
messages: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity).

9823:KCNMB1
gene id: 9823:KCNMB1
uniprot id: A0A8D0R9C7
uniprot id: F1RRX5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9823:LOC100523829
gene id: 9823:LOC100523829
uniprot id: A0A4X1UVG8
uniprot id: F1SSI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ANXA1
gene id: 9823:ANXA1
uniprot id: P19619
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Detected in lung and spleen (at protein level).
messages: Early endosome
messages: Endosome
messages: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
messages: Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation. Homodimers linked by transglutamylation are observed in placenta, but not in other tissues. Interacts with S100A11. Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (By similarity). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: Phosphorylated by EGFR (PubMed:3020049). Phosphorylated by protein kinase C and TRPM7 (By similarity). Phosphorylated in response to EGF treatment (PubMed:3020049).
messages: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (PubMed:12595246). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:8885232). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
messages: Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26.
messages: Secreted
messages: Sumoylated.
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9823:C14H12orf49
gene id: 9823:C14H12orf49
uniprot id: A0A480VC18
uniprot id: A0A4X1TRP6
uniprot id: A0A4X1TRQ7
uniprot id: A0A8D1DJX6
uniprot id: A0A8D1DKP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

9823:LVRN
gene id: 9823:LVRN
uniprot id: A0A5G2QQR1
uniprot id: A0A8D0S272
uniprot id: A0A8D1XGG9
uniprot id: F1RLE3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9823:PER1
gene id: 9823:PER1
uniprot id: A0A8D1RLF4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:PPM1G
gene id: 9823:PPM1G
uniprot id: A0A287BJ42
uniprot id: A0A4X1TLS0
names: Similarity
messages: Belongs to the PP2C family.

9823:TMEM231
gene id: 9823:TMEM231
uniprot id: A0A8D1L287
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

9823:DHRS7C
gene id: 9823:DHRS7C
uniprot id: A0A8D1APZ6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:CNOT9
gene id: 9823:CNOT9
uniprot id: A0A4X1UK79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9823:OLFM2
gene id: 9823:OLFM2
uniprot id: I3L7A4
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9823:CD200
gene id: 9823:CD200
uniprot id: A0A286ZHZ7
uniprot id: A0A287A9T6
uniprot id: A0A4X1SUV8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:CNPY2
gene id: 9823:CNPY2
uniprot id: A0A4X1W9B8
uniprot id: F1SLY7
names: Similarity
messages: Belongs to the canopy family.

9823:APOD
gene id: 9823:APOD
uniprot id: A0A4X1U1N6
uniprot id: F1SQX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.
messages: Secreted

9823:CD82
gene id: 9823:CD82
uniprot id: A0A4X1SFI7
uniprot id: B7ZEQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:CLDN10
gene id: 9823:CLDN10
uniprot id: A0A4X1UXL7
uniprot id: F1RP52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:IL12A
gene id: 9823:IL12A
uniprot id: Q29053
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12. Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
messages: Secreted

9823:ANKRD34B
gene id: 9823:ANKRD34B
uniprot id: A0A8D1ZXH1
uniprot id: F1RF21
names: Similarity
messages: Belongs to the ANKRD34 family.

9823:PLA2G2F
gene id: 9823:PLA2G2F
uniprot id: A0A8D1QDW1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9823:PQLC3
gene id: 9823:PQLC3
uniprot id: A0A4X1U8X0
uniprot id: F1SAA6
names: Subcellular Location Annotation
messages: Membrane

9823:DEFB123
gene id: 9823:DEFB123
uniprot id: A0A4X1SP61
uniprot id: F1S7H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9823:ATRAID
gene id: 9823:ATRAID
uniprot id: A0A480LCP7
uniprot id: A0A4X1TSH5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:ACTA2
gene id: 9823:ACTA2
uniprot id: A0A4X1V3S0
uniprot id: C7AI81
names: Similarity
messages: Belongs to the actin family.

9823:PDHB
gene id: 9823:PDHB
uniprot id: A0A4X1VIG0
uniprot id: F1SGH5
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9823:TUSC5
gene id: 9823:TUSC5
uniprot id: A0A8D1PQW6
uniprot id: A8D9X0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:RPS29
gene id: 9823:RPS29
uniprot id: Q6QAP6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9823:LOC106509345
gene id: 9823:LOC106509345
uniprot id: A0A8D0RHW1
uniprot id: F1RMF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100520009
gene id: 9823:LOC100520009
uniprot id: A0A4X1V337
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PIGM
gene id: 9823:PIGM
uniprot id: A0A287A5F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9823:RAB39B
gene id: 9823:RAB39B
uniprot id: A0A4X1TA44
uniprot id: F2Z552
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9823:ADPRH
gene id: 9823:ADPRH
uniprot id: A0A4X1T2M5
uniprot id: F1SPB1
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9823:SLC4A5
gene id: 9823:SLC4A5
uniprot id: A0A8D1QT65
uniprot id: L0N3Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9823:RIBC1
gene id: 9823:RIBC1
uniprot id: A0A5G2R4Y0
uniprot id: A0A8D0YSQ9
names: Similarity
messages: Belongs to the RIB43A family.

9823:SLC1A3
gene id: 9823:SLC1A3
uniprot id: A0A287BI76
uniprot id: A0A4X1TA36
uniprot id: A0A4X1TC18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9823:IMP3
gene id: 9823:IMP3
uniprot id: A0A8D0X6D5
uniprot id: F1SJ73
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9823:STAT6
gene id: 9823:STAT6
uniprot id: A0A4X1W175
uniprot id: E1U8C5
uniprot id: E5F1H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9823:LOC100738859
gene id: 9823:LOC100738859
uniprot id: A0A287BID4
uniprot id: A0A4X1SJ54
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:CLDN15
gene id: 9823:CLDN15
uniprot id: A0A8D0YXD8
uniprot id: C3VMK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:CCDC124
gene id: 9823:CCDC124
uniprot id: A0A4X1UBM2
uniprot id: F1S924
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

9823:C7H6orf89
gene id: 9823:C7H6orf89
uniprot id: A0A481BEW9
uniprot id: A0A8D0U617
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9823:TXK
gene id: 9823:TXK
uniprot id: A0A4X1UHV6
uniprot id: A0A4X1UJL4
uniprot id: F1SEA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9823:DHRS4
gene id: 9823:DHRS4
uniprot id: A0A480VYS5
uniprot id: Q8WNV7
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Detected in heart, kidney, liver and small intestine. Detected at lower levels in brain, lung, stomach and spleen.
messages: Homotetramer.
messages: Inhibited by kaempferol, quercetin, genistein and myristic acid.
messages: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones (PubMed:12604222, PubMed:19056333). Reduces all-trans-retinal and 9-cis retinal (Probable). Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin (PubMed:19056333). In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency (PubMed:19056333). Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds (PubMed:12604222, PubMed:19056333).
messages: Peroxisome
messages: Primate DHRS4s display different stereoselectivity and catalytic efficiency in the oxidoreduction of some substrates as compared to other mammal DHRS4s due to a difference in conserved amino acid residues.
messages: The C-terminus peroxisomal targeting signal tripeptide is important for peroxisomal import. Once in the peroxisome, it is involved in intersubunit interactions.
messages: Three specific residues, Phe-177, Leu-180 and Asn-196 are conserved between non-primate mammals whereas the respective residues are serine, phenylalanine and threonine in primates (PubMed:19056333). The two residues at positions 177 and 180 are molecular determinants responsible for the stereoselective reduction of 3-ketosteroids and benzil (PubMed:19056333). The presence of an asparagine at position 196 is important for the maintenance of the quaternary structure resulting in stability at cold temperature and improved catalytic activity toward retinal (PubMed:19056333).

9823:CLK3
gene id: 9823:CLK3
uniprot id: A0A4X1TKM3
uniprot id: F1SIE6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:LOC100524554
gene id: 9823:LOC100524554
uniprot id: A0A4X1W253
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9823:SLC25A27
gene id: 9823:SLC25A27
uniprot id: A0A480X2I8
uniprot id: A0A4X1V4Z9
uniprot id: A0A8D0W2M8
uniprot id: D9IZY8
uniprot id: I3LSK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:SPOCK1
gene id: 9823:SPOCK1
uniprot id: A0A286ZS89
uniprot id: A0A4X1V4C9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:NDUFB1
gene id: 9823:NDUFB1
uniprot id: A0A8D2CGH8
uniprot id: F1SD73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:FOXL2
gene id: 9823:FOXL2
uniprot id: A0A480Z083
uniprot id: Q6VFT6
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ESR1. Interacts with UBE2I/UBC9. Interacts with SMAD3. Interacts with DDX20.
messages: Nucleus
messages: Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
messages: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates transcription of OSR2 (By similarity). Is a regulator of CYP19 expression (By similarity). Is a transcriptional repressor of STAR (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity).

9823:LGI1
gene id: 9823:LGI1
uniprot id: A0A8D0X5U1
uniprot id: F1SC71
names: Subcellular Location Annotation
messages: Secreted

9823:POSTN
gene id: 9823:POSTN
uniprot id: A0A4X1STN4
uniprot id: A0A4X1SVF9
uniprot id: D3K5K1
uniprot id: F1RS37
uniprot id: I3LDM1
names: Subcellular Location Annotation
messages: extracellular matrix

9823:HSPA6
gene id: 9823:HSPA6
uniprot id: Q04967
names: Domain
names: Function
names: Induction
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: By heat shock.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.

9823:RBM8A
gene id: 9823:RBM8A
uniprot id: A0A4X1SJG3
uniprot id: I3LI59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9823:COMP
gene id: 9823:COMP
uniprot id: A0A8D1U7D8
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:PSP-I
gene id: 9823:PSP-I
uniprot id: P35495
uniprot id: Q4R0H6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the spermadhesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer or heterodimer with PSP-II (depending on the type of glycosylation of PSP-I).
messages: Not yet identified, major porcine seminal plasma protein. Can bind soybean trypsin inhibitor after deglycosylation.
messages: Secreted
messages: Seminal plasma or sperm.

9823:CACYBP
gene id: 9823:CACYBP
uniprot id: A0A4X1U960
uniprot id: A0A4X1UEL0
uniprot id: A0A5G2QG77
uniprot id: F1S710
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9823:SRPRA
gene id: 9823:SRPRA
uniprot id: A0A8D0U477
uniprot id: K9IVR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

9823:SRD5A2
gene id: 9823:SRD5A2
uniprot id: O18765
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity).
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9823:INO80
gene id: 9823:INO80
uniprot id: A0A4X1UTT6
uniprot id: F1SSV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9823:LOC100620470
gene id: 9823:LOC100620470
uniprot id: A0A4X1W6H0
uniprot id: I3LHQ6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:GATA3
gene id: 9823:GATA3
uniprot id: Q0ZHH4
names: Subcellular Location Annotation
messages: Nucleus

9823:NCF2
gene id: 9823:NCF2
uniprot id: A0A480TE35
uniprot id: A0A8D1X9Z6
uniprot id: B1PK10
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9823:EN1
gene id: 9823:EN1
uniprot id: A0A4X1SM98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

9823:IFI44
gene id: 9823:IFI44
uniprot id: F4ZS17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI44 family.
messages: Cytoplasm

9823:SF3B1
gene id: 9823:SF3B1
uniprot id: A0A286ZHW0
uniprot id: A0A4X1VGU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9823:HCST
gene id: 9823:HCST
uniprot id: A0A5S6FW47
uniprot id: A0A8D0NFP4
uniprot id: Q9GJR5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DAP10 family.
messages: Expressed predominantly in lymphohematopoietic tissues.
messages: Homodimer; Disulfide-linked. Heterohexamer composed of four subunits of HCST/DAP10 and two subunits of KLRK1. Interacts (via transmembrane domain) with KLRK1 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Interacts with PIK3R1 and GRB2. Interacts with CLEC5A. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP (By similarity). Interacts with KLRK1. Interacts with CD300H (By similarity).
messages: Membrane
messages: O-glycosylated.
messages: Phosphorylated; PIK3R1 and GRB2 associate specifically with tyrosine-phosphorylated HCST.
messages: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity).

9823:PABPC4
gene id: 9823:PABPC4
uniprot id: A0A287BQ02
uniprot id: A0A4X1VV02
uniprot id: A0A4X1VW37
uniprot id: A0A8D1UNY1
uniprot id: F1SV06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9823:C7H15orf40
gene id: 9823:C7H15orf40
uniprot id: A0A8D0IZB8
uniprot id: F1RIB1
names: Similarity
messages: Belongs to the UPF0235 family.

9823:CLDN3
gene id: 9823:CLDN3
uniprot id: C3VPJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:UGP2
gene id: 9823:UGP2
uniprot id: P79303
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Cytoplasm
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9823:PRSS12
gene id: 9823:PRSS12
uniprot id: F1S153
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

9823:LOC100516632
gene id: 9823:LOC100516632
uniprot id: A0A8D1LNZ3
uniprot id: I3LLI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RAMP1
gene id: 9823:RAMP1
uniprot id: Q867C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAMP family.
messages: Heterodimer of CALCRL and RAMP1.
messages: Membrane
messages: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL (By similarity).

9823:RAG2
gene id: 9823:RAG2
uniprot id: A0A4X1SJH9
uniprot id: Q867B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9823:CLRN2
gene id: 9823:CLRN2
uniprot id: A0A4X1V8B3
uniprot id: I3LUJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9823:TRPT1
gene id: 9823:TRPT1
uniprot id: A0A8D0VL97
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

9823:ADAMTS9
gene id: 9823:ADAMTS9
uniprot id: A0A4X1VEL0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:FAM199X
gene id: 9823:FAM199X
uniprot id: A0A4X1W440
uniprot id: K7GS69
names: Similarity
messages: Belongs to the FAM199 family.

9823:APEH
gene id: 9823:APEH
uniprot id: P19205
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

9823:MAP1LC3B
gene id: 9823:MAP1LC3B
uniprot id: A0A4X1T8W3
uniprot id: D7RA29
names: Similarity
messages: Belongs to the ATG8 family.

9823:GABRA6
gene id: 9823:GABRA6
uniprot id: A0A4X1TXJ7
uniprot id: F1RR70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:TLR7
gene id: 9823:TLR7
uniprot id: A4LAL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane
messages: phagosome

9823:CAPG
gene id: 9823:CAPG
uniprot id: A0A8D1U9S4
uniprot id: F1SVB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
messages: Cytoplasm
messages: Melanosome
messages: Nucleus
messages: lamellipodium
messages: ruffle

9823:CMAH
gene id: 9823:CMAH
uniprot id: A8WAC5
names: Function
names: Similarity
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

9823:DBH
gene id: 9823:DBH
uniprot id: A0A4X1SZ01
uniprot id: F1S041
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Conversion of dopamine to noradrenaline.
messages: Homotetramer; composed of two disulfide-linked dimers.
messages: chromaffin granule lumen
messages: chromaffin granule membrane
messages: secretory vesicle lumen
messages: secretory vesicle membrane

9823:LOC100154081
gene id: 9823:LOC100154081
uniprot id: A0A287AYP1
uniprot id: A0A4X1VF47
names: Similarity
messages: Belongs to the NipSnap family.

9823:RPS24
gene id: 9823:RPS24
uniprot id: A0A4X1SJJ2
uniprot id: A0A4X1SJK8
uniprot id: A0A4X1V4V5
uniprot id: A0A5G2QXQ1
uniprot id: A0A5G2R1Y0
uniprot id: A0A8D0T6Q4
uniprot id: I3LJP6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9823:TCEANC2
gene id: 9823:TCEANC2
uniprot id: A0A480K3P7
uniprot id: A0A4X1WAX2
names: Subcellular Location Annotation
messages: Nucleus

9823:HMMR
gene id: 9823:HMMR
uniprot id: A0A5G2RBP4
uniprot id: A0A8D0ZZB4
names: Subcellular Location Annotation
messages: spindle

9823:PDK1
gene id: 9823:PDK1
uniprot id: A0A8D1EH84
uniprot id: F1S069
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9823:WEE1
gene id: 9823:WEE1
uniprot id: A0A4X1TU94
uniprot id: F1S6U8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

9823:PTPN13
gene id: 9823:PTPN13
uniprot id: A0A4X1U3A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9823:CCR7
gene id: 9823:CCR7
uniprot id: A0A8D1CVB1
uniprot id: Q861S1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:PRPH
gene id: 9823:PRPH
uniprot id: A0A8D1D2E4
uniprot id: F1SHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon

9823:BCO1
gene id: 9823:BCO1
uniprot id: B6UV63
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9823:DECR2
gene id: 9823:DECR2
uniprot id: A0A287BS11
uniprot id: A0A4X1UK46
uniprot id: A0A4X1UNX2
uniprot id: F1RGV4
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

9823:NCBP3
gene id: 9823:NCBP3
uniprot id: A0A8D0WJB2
uniprot id: F1RGS3
names: Similarity
messages: Belongs to the NCBP3 family.

9823:EBF2
gene id: 9823:EBF2
uniprot id: A0A4X1V8U1
uniprot id: F2Z510
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9823:ENPP4
gene id: 9823:ENPP4
uniprot id: A0A8D1QZ30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

9823:JPH4
gene id: 9823:JPH4
uniprot id: A0A8D1WR17
uniprot id: F1SS43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9823:MSN
gene id: 9823:MSN
uniprot id: A0A287BED9
uniprot id: A0A4X1VJQ8
uniprot id: P26042
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
messages: Apical cell membrane
messages: Binds SLC9A3R1. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Interacts with PPP1R16B. Interacts with PDZD8. Interacts with SELPLG and SYK; mediates the activation of SYK by SELPLG. Interacts with PDPN (via cytoplasmic domain); activates RHOA and promotes epithelial-mesenchymal transition. Interacts with SPN/CD43 cytoplasmic tail, CD44 and ICAM2 (By similarity).
messages: Cell membrane
messages: Membrane
messages: Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization (By similarity).
messages: Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation.
messages: S-nitrosylation of Cys-117 is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) implicating the iNOS-S100A8/9 transnitrosylase complex.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: cytoskeleton
messages: microvillus
messages: microvillus membrane

9823:LOC100525869
gene id: 9823:LOC100525869
uniprot id: A0A287AZF9
uniprot id: A0A4X1UNI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Membrane
messages: Mitochondrion inner membrane

9823:LOC100624836
gene id: 9823:LOC100624836
uniprot id: A0A4X1VCJ4
uniprot id: F1RXT1
names: Similarity
messages: Belongs to the FAM47 family.

9823:CMC1
gene id: 9823:CMC1
uniprot id: A0A4X1UHR4
uniprot id: A0A5G2QBF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9823:CBFA2T2
gene id: 9823:CBFA2T2
uniprot id: A0A4X1T2W3
uniprot id: A0A8D1MV45
uniprot id: I3LQB8
names: Similarity
messages: Belongs to the CBFA2T family.

9823:CALCB
gene id: 9823:CALCB
uniprot id: A0A4X1TFF8
uniprot id: A0A8D0M1S4
uniprot id: A6P7L6
uniprot id: A6P7L7
uniprot id: Q862B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calcitonin family.
messages: Mainly expressed in the thyroid gland and CNS. Found in the nerve cells of cerebrum, hippocampus, hypothalamus, pons/midbrain and thalamus.
messages: Secreted
messages: Stimulates cAMP production in porcine kidney cell line LLC-PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor.

9823:MRPL36
gene id: 9823:MRPL36
uniprot id: A0A8D0S053
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9823:DCTD
gene id: 9823:DCTD
uniprot id: A0A4X1VYR1
uniprot id: F1RT14
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9823:DCPS
gene id: 9823:DCPS
uniprot id: Q8MIZ3
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus
messages: The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping activity. The N-terminus is necessary but not sufficient for binding cap structures.
messages: The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping scavenger activity and acts as a competitive inhibitor in vitro. Inhibited by 2,4-diaminoquinazoline.

9823:MAT1A
gene id: 9823:MAT1A
uniprot id: A0A4X1SHI9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9823:LOC100738814
gene id: 9823:LOC100738814
uniprot id: A0A0G3VRU7
uniprot id: A0A4X1TNG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:RSAD2
gene id: 9823:RSAD2
uniprot id: Q9MZU4
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Lys-6'-linked polyubiquitination at Lys-207 leads to RSAD2 protein degradation.
messages: Acetylated by HAT1. HAT1-mediated acetylation of Lys-198 in turn recruits UBE4A that stimulates RSAD2 polyubiquitination leading to proteasomal degradation.
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: By interferon type I, type II and LPS.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Homodimer. Interacts with IRAK1 and TRAF6. Interacts with FPPS. Interacts with HADHB. Interacts (via C-terminus) with VAPA/VAP33 (via C-terminus).
messages: IRAK1 and TRAF6 synergistically activate RSAD2 increasing its activity with CTP as substrate about 10-fold.
messages: Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses (PubMed:32719955, PubMed:31517388). Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins (By similarity).
messages: Lipid droplet
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: The N-terminal region (1-42) is necessary for its localization to the endoplasmic reticulum membrane and lipid droplet.

9823:FERMT3
gene id: 9823:FERMT3
uniprot id: A0A480K0R6
uniprot id: A0A4X1VGB7
names: Similarity
messages: Belongs to the kindlin family.

9823:MIP
gene id: 9823:MIP
uniprot id: A0A4X1W841
uniprot id: F1SLB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:GINS2
gene id: 9823:GINS2
uniprot id: A0A287A814
uniprot id: A0A8D1J2B2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9823:TEX261
gene id: 9823:TEX261
uniprot id: A0A4X1W993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9823:ATPAF1
gene id: 9823:ATPAF1
uniprot id: A0A8D1F5W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

9823:PPARD
gene id: 9823:PPARD
uniprot id: A0A4X1T1Q5
uniprot id: A9XAM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:CDH5
gene id: 9823:CDH5
uniprot id: B4YYE0
uniprot id: O02840
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity).
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4 (By similarity). Interacts with KRIT1 (By similarity). Interacts with PARD3 (By similarity). Interacts with RTN4 (isoform B) (By similarity). Interacts with PALS1; the interaction promotes PALS1 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell (By similarity).
messages: Membrane
messages: O-glycosylated.
messages: Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9823:FLOT1
gene id: 9823:FLOT1
uniprot id: A0A480IKJ2
uniprot id: A0A8D0N671
uniprot id: Q767L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Melanosome
messages: Membrane
messages: Membrane raft
messages: caveola

9823:BTNL9
gene id: 9823:BTNL9
uniprot id: A0A8D0YN28
uniprot id: I3LLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9823:CD2
gene id: 9823:CD2
uniprot id: Q764N3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SFRP5
gene id: 9823:SFRP5
uniprot id: A0A4X1U966
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:KCNJ10
gene id: 9823:KCNJ10
uniprot id: A0A287B806
uniprot id: A0A8D0QMI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9823:PARD6G
gene id: 9823:PARD6G
uniprot id: A0A4X1SD12
uniprot id: I3LSR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9823:PARP2
gene id: 9823:PARP2
uniprot id: A0A4X1UUM0
uniprot id: F1S8F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9823:HEXA
gene id: 9823:HEXA
uniprot id: B1PK15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9823:KRT79
gene id: 9823:KRT79
uniprot id: I3LLY8
names: Similarity
messages: Belongs to the intermediate filament family.

9823:CDK5R1
gene id: 9823:CDK5R1
uniprot id: A7LNG6
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

9823:UGCG
gene id: 9823:UGCG
uniprot id: A0A4X1V638
uniprot id: I3LPG3
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9823:PDIA6
gene id: 9823:PDIA6
uniprot id: A0A4X1UE18
uniprot id: E1CAJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

9823:LOC100519930
gene id: 9823:LOC100519930
uniprot id: A0A4X1UAI6
uniprot id: F1SK09
names: Similarity
messages: Belongs to the histone H2B family.

9823:HSP90AB1
gene id: 9823:HSP90AB1
uniprot id: A0A4X1V534
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9823:TYK2
gene id: 9823:TYK2
uniprot id: A0A8D1VBB5
uniprot id: Q684M7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9823:APH1A
gene id: 9823:APH1A
uniprot id: A0A4X1SIA7
uniprot id: I3L8R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9823:MRPL40
gene id: 9823:MRPL40
uniprot id: A0A286ZP98
uniprot id: A0A4X1UTT8
uniprot id: A0A5G2R2V2
uniprot id: A0A8D0SU37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9823:POLR3F
gene id: 9823:POLR3F
uniprot id: A0A4X1V161
uniprot id: A0A8D0ML72
uniprot id: F1SBH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9823:TNFAIP3
gene id: 9823:TNFAIP3
uniprot id: A0A4X1VL00
uniprot id: F1S6A4
uniprot id: G9M4M9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:ACTN2
gene id: 9823:ACTN2
uniprot id: A0A8D0XC36
uniprot id: F1RHL9
names: Similarity
messages: Belongs to the alpha-actinin family.

9823:GABRQ
gene id: 9823:GABRQ
uniprot id: K7GR83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:LOC100625080
gene id: 9823:LOC100625080
uniprot id: A0A8D0WZI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:B2M
gene id: 9823:B2M
uniprot id: B2NJ26
uniprot id: Q07717
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

9823:KRT2
gene id: 9823:KRT2
uniprot id: A0A8D1AGQ1
uniprot id: A5A759
names: Similarity
messages: Belongs to the intermediate filament family.

9823:DSTN
gene id: 9823:DSTN
uniprot id: P60982
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
messages: Belongs to the actin-binding proteins ADF family.
messages: ISGylated.
messages: Widely distributed in various tissues.

9823:CCL22
gene id: 9823:CCL22
uniprot id: G8XRI5
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9823:PRICKLE3
gene id: 9823:PRICKLE3
uniprot id: A0A4X1SYC1
uniprot id: F1RW44
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9823:PPP3CB
gene id: 9823:PPP3CB
uniprot id: A0A8D1H101
uniprot id: A0A8D1XDF9
uniprot id: F1SU57
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9823:DUOXA1
gene id: 9823:DUOXA1
uniprot id: A0A4X1VEG9
uniprot id: F1SN40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9823:LCLAT1
gene id: 9823:LCLAT1
uniprot id: A0A4X1TGC3
uniprot id: B7U2H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9823:TMED5
gene id: 9823:TMED5
uniprot id: A0A287A5G3
uniprot id: A0A4X1U2C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with TMED9 and TMED10.
messages: Membrane
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.
messages: cis-Golgi network membrane

9823:GLI2
gene id: 9823:GLI2
uniprot id: A0A8D0QV02
uniprot id: F1RXX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9823:TSPAN17
gene id: 9823:TSPAN17
uniprot id: A0A287AQI5
uniprot id: A0A4X1SIL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:CRYL1
gene id: 9823:CRYL1
uniprot id: Q8SQ26
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Cytoplasm
messages: Has high L-gulonate 3-dehydrogenase activity. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate.
messages: Homodimer.
messages: Inhibited by malonate.

9823:GPR180
gene id: 9823:GPR180
uniprot id: A0A287AT35
uniprot id: A0A287BQ92
uniprot id: A0A4X1UZM7
names: Subcellular Location Annotation
messages: Membrane

9823:DCTN6
gene id: 9823:DCTN6
uniprot id: A0A4X1VN73
uniprot id: D0G6S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9823:YPEL2
gene id: 9823:YPEL2
uniprot id: A0A287AI02
uniprot id: A0A4X1SQP7
names: Similarity
messages: Belongs to the yippee family.

9823:C6H19orf54
gene id: 9823:C6H19orf54
uniprot id: A0A286ZWY2
uniprot id: A0A4X1SPP7
names: Similarity
messages: Belongs to the UPF0692 family.

9823:SMG8
gene id: 9823:SMG8
uniprot id: A0A8D1ABR3
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

9823:TBX3
gene id: 9823:TBX3
uniprot id: A0A4X1TM24
uniprot id: A0A8D1BL22
uniprot id: F1RKD4
uniprot id: I3LVI3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:DRD1
gene id: 9823:DRD1
uniprot id: P50130
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Endoplasmic reticulum membrane
messages: Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD2 (By similarity).
messages: dendrite
messages: dendritic spine

9823:DCK
gene id: 9823:DCK
uniprot id: A0A4X1TA10
uniprot id: F1RUN9
names: Similarity
messages: Belongs to the DCK/DGK family.

9823:DCLRE1A
gene id: 9823:DCLRE1A
uniprot id: A0A8D0R7I6
uniprot id: F1S5H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9823:TSPAN6
gene id: 9823:TSPAN6
uniprot id: A0A4X1U084
uniprot id: A0A5G2QQQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:OAZ1
gene id: 9823:OAZ1
uniprot id: B2CR15
names: Similarity
messages: Belongs to the ODC antizyme family.

9823:HSDL1
gene id: 9823:HSDL1
uniprot id: A0A286ZT08
uniprot id: A0A4X1T2G6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:PORCN
gene id: 9823:PORCN
uniprot id: A0A287A5T7
uniprot id: A0A287B2I9
uniprot id: A0A4X1VEY2
uniprot id: A0A4X1VKA3
uniprot id: A0A4X1VLP4
uniprot id: A0A8D1P6V5
uniprot id: I3LFC9
uniprot id: I3LRY6
names: Subcellular Location Annotation
messages: Membrane

9823:GPHA2
gene id: 9823:GPHA2
uniprot id: A0A8D1VV97
names: Caution
names: Function
names: Similarity
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9823:SEPT2
gene id: 9823:SEPT2
uniprot id: A0A4X1SZY0
uniprot id: F1SIP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9823:RPL31
gene id: 9823:RPL31
uniprot id: P62901
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9823:NAPB
gene id: 9823:NAPB
uniprot id: A0A480DU21
uniprot id: A0A4X1V0Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9823:SLC44A2
gene id: 9823:SLC44A2
uniprot id: A0A286ZZB8
uniprot id: A0A4X1V6Z0
uniprot id: F1S584
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Interacts with COCH.
messages: Membrane
messages: N-glycosylated.

9823:PIWIL1
gene id: 9823:PIWIL1
uniprot id: D9YJ48
names: Similarity
messages: Belongs to the argonaute family.

9823:CNOT11
gene id: 9823:CNOT11
uniprot id: A0A4X1VWP1
uniprot id: F1STG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

9823:GALE
gene id: 9823:GALE
uniprot id: A0A480P9F6
uniprot id: A0A4X1VTU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9823:B3GALT1
gene id: 9823:B3GALT1
uniprot id: A0A287B819
uniprot id: A0A4X1VGL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:IFN-OMEGA-7
gene id: 9823:IFN-OMEGA-7
uniprot id: B3VSC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:LOC100522686
gene id: 9823:LOC100522686
uniprot id: A0A4X1VJ80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:HSPA4
gene id: 9823:HSPA4
uniprot id: A0A4X1UY89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9823:LOC100152708
gene id: 9823:LOC100152708
uniprot id: A0A4X1VFH9
uniprot id: F1S7N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:HNRNPK
gene id: 9823:HNRNPK
uniprot id: A0A8D1XIB0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9823:IFN-ALPHA-15
gene id: 9823:IFN-ALPHA-15
uniprot id: C8CKA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:SCG2
gene id: 9823:SCG2
uniprot id: Q5FZP5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Binds calcium with a low-affinity.
messages: Interacts with Secretogranin III/SCG3.
messages: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
messages: Secreted

9823:ECHDC1
gene id: 9823:ECHDC1
uniprot id: A0A286ZZC3
uniprot id: A0A4X1UF11
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9823:PHACTR1
gene id: 9823:PHACTR1
uniprot id: A0A287BEZ9
uniprot id: A0A8D0SGJ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

9823:SH2D1A
gene id: 9823:SH2D1A
uniprot id: Q06AA1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (By similarity).
messages: Interacts with CD84, CD244, LY9, SLAMF1 and FYN. Interacts with NTRK1, NTRK2 and NTRK3 (By similarity).

9823:IRF2BPL
gene id: 9823:IRF2BPL
uniprot id: A0A480TTF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9823:MYH7
gene id: 9823:MYH7
uniprot id: P79293
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with ECPAS. Interacts (via C-terminus) with LRRC39.
messages: Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).
messages: The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Four skip residues (Skip1: Thr-1188, Skip2: Glu-1385, Skip3: Glu-1582 and Skip4: Gly-1807) introduce discontinuities in the coiled-coil heptad repeats. The first three skip residues are structurally comparable and induce a unique local relaxation of the coiled-coil superhelical pitch and the fourth skip residue lies within a highly flexible molecular hinge that is necessary for myosin incorporation in the bare zone of sarcomeres.
messages: myofibril
messages: sarcomere

9823:TPI1
gene id: 9823:TPI1
uniprot id: Q29371
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9823:LOC100522627
gene id: 9823:LOC100522627
uniprot id: F1RNG2
names: Subcellular Location Annotation
messages: Membrane

9823:LOC100521984
gene id: 9823:LOC100521984
uniprot id: A0A4X1TEG1
uniprot id: A0A5G2QHG3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SNPH
gene id: 9823:SNPH
uniprot id: A0A8D0VED3
names: Subcellular Location Annotation
messages: Membrane

9823:CAMK2N2
gene id: 9823:CAMK2N2
uniprot id: A0A8D0S7X2
uniprot id: I3LU01
names: Similarity
messages: Belongs to the CAMK2N family.

9823:C3
gene id: 9823:C3
uniprot id: P01025
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a chemoattractant for neutrophils in chronic inflammation.
messages: Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in post-prandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-internalization and recycling of C5AR2 (By similarity).
messages: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (By similarity).
messages: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). Forms the pro-C3-convertase enzyme complex by binding to Complement factor B Bb fragment (Bb), which is then stabilized by binding CFP, allowing the complex to become active (By similarity). The interaction with Bb is dependent on Mg2+ (By similarity). C3b interacts with CR1 (via Sushi 8 and Sushi 9 domains). C3b interacts with CFH. C3d interacts with CFH. C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with VSIG4. Interacts with S.aureus immunoglobulin-binding protein sbi, this prevents interaction between C3dg and CR2. Interacts with S.aureus fib. Interacts (both C3a and ASP) with C5AR2; the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of C5AR2, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.
messages: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxylases to release the C-termianl arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin and dietary chylomicrons (By similarity).
messages: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity).
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Secreted

9823:DPPA5
gene id: 9823:DPPA5
uniprot id: A0A8D1ZBD4
uniprot id: C3U2T0
names: Similarity
messages: Belongs to the KHDC1 family.

9823:HIGD1A
gene id: 9823:HIGD1A
uniprot id: A0A4X1TJ06
uniprot id: F1SRE7
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9823:HYAL2
gene id: 9823:HYAL2
uniprot id: A0A4X1SK14
uniprot id: A0A5K1TZ96
uniprot id: Q6RHW3
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9823:TRAM1
gene id: 9823:TRAM1
uniprot id: A0A287BDF6
uniprot id: A0A4X1UPH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9823:HNRNPAB
gene id: 9823:HNRNPAB
uniprot id: A9ED96
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:SLC6A13
gene id: 9823:SLC6A13
uniprot id: A0A8D0YZT0
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Membrane

9823:LOC100511983
gene id: 9823:LOC100511983
uniprot id: A0A8D1UA78
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:IZUMO4
gene id: 9823:IZUMO4
uniprot id: A0A287BKY5
uniprot id: A0A8D0R5M2
names: Similarity
messages: Belongs to the Izumo family.

9823:TMED4
gene id: 9823:TMED4
uniprot id: A0A8D1PZN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:ST7
gene id: 9823:ST7
uniprot id: A0A8D0Y057
uniprot id: Q2QLD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9823:LOC100516454
gene id: 9823:LOC100516454
uniprot id: A0A8D1FAF9
uniprot id: F1S808
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:AURKA
gene id: 9823:AURKA
uniprot id: A4UTN8
uniprot id: A5GFW1
uniprot id: Q4R1K4
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment (By similarity). Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase (By similarity). Autophosphorylated at Thr-288 upon TPX2 binding (By similarity). Thr-288 can be phosphorylated by several kinases, including PAK and PKA (By similarity). Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis (By similarity). Phosphorylation at Ser-342 decreases the kinase activity (By similarity). PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis (By similarity).
messages: Activation of CDK1, appears to be an upstream event of AURKA activation (By similarity). Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators (By similarity). Inactivated by the G2 checkpoint (By similarity). Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1) (By similarity). MLN8054 is also a potent and selective inhibitor (By similarity). Activated during the early phase of cilia disassembly in the presence of PIFO (By similarity). Inhibited by the small molecule inhibitor VX-680 (By similarity).
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (By similarity). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (By similarity). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for initial activation of CDK1 at centrosomes (By similarity). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (By similarity). Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation (By similarity). Plays a role in microtubule remodeling during neurite extension (By similarity). Important for microtubule formation and/or stabilization (By similarity). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (By similarity). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (By similarity).
messages: Part of a complex composed of NEDD9, AURKA and CTTN; within the complex NEDD9 acts as a scaffold protein and is required for complex formation (By similarity). Identified in a complex with AUNIP and NIN (By similarity). Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts also with its substrates ARHGEF2, BORA, KIF2A, PARD3, and p53/TP53 (By similarity). Interaction with BORA promotes phosphorylation of PLK1 (By similarity). Interacts with PIFO (By similarity). Interacts with GADD45A, competing with its oligomerization (By similarity). Interacts (via C-terminus) with AUNIP (via C-terminus) (By similarity). Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation (By similarity). Interacts with SIRT2 (By similarity). Interacts with MYCN; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN (By similarity). Interacts with HNRNPU (By similarity). Interacts with AAAS (By similarity). Interacts with KLHL18 and CUL3 (By similarity). Interacts with FOXP1 (By similarity). Interacts with HDAC6; AURKA-mediated phosphorylation of HDAC6 promotes deacetylation of alpha-tubulin (By similarity).
messages: Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome (By similarity). Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the CUL3-KLHL18 ligase leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). Ubiquitination mediated by CUL3-KLHL18 ligase does not lead to its degradation by the proteasome (By similarity).
messages: centriole
messages: centrosome
messages: cilium
messages: cilium basal body
messages: neuron projection
messages: spindle pole

9823:ZSCAN10
gene id: 9823:ZSCAN10
uniprot id: I3LSX1
names: Subcellular Location Annotation
messages: Nucleus

9823:WNT16
gene id: 9823:WNT16
uniprot id: A0A8D0PVA1
uniprot id: F1SJF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:GPC3
gene id: 9823:GPC3
uniprot id: A0A8D1DTY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9823:C3H2orf68
gene id: 9823:C3H2orf68
uniprot id: A0A4X1W7B1
uniprot id: F1SVB5
names: Similarity
messages: Belongs to the UPF0561 family.

9823:PI4KA
gene id: 9823:PI4KA
uniprot id: A0A480IQK1
uniprot id: A0A8D1S7Q5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9823:APOBEC1
gene id: 9823:APOBEC1
uniprot id: F1SLW4
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9823:SUMF1
gene id: 9823:SUMF1
uniprot id: A0A480WFL8
uniprot id: A0A8D0ZT85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9823:LTB
gene id: 9823:LTB
uniprot id: A0A4X1VFT3
uniprot id: A5D9N6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:TCTN1
gene id: 9823:TCTN1
uniprot id: A0A480JQD0
uniprot id: A0A4X1U4H6
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9823:GALNT11
gene id: 9823:GALNT11
uniprot id: A0A287B5N4
uniprot id: A0A4X1UHW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9823:GGT1
gene id: 9823:GGT1
uniprot id: A0A4X1V1S5
uniprot id: A0A5K1UGB8
uniprot id: P20735
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by autocatalytic cleavage.
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cell membrane
messages: Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme.
messages: Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Heterodimer composed of the light and heavy chains. The active site is located in the light chain.
messages: Highly expressed in kidney. Detected at lower levels in liver, lung, plexus choroideus and brain capillary endothelial cells.
messages: Membrane
messages: N-glycosylated on both chains.

9823:ZNF703
gene id: 9823:ZNF703
uniprot id: A0A8D0ZTG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

9823:TUBB
gene id: 9823:TUBB
uniprot id: A0A480TK33
uniprot id: Q767L7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Heterodimer of alpha and beta chains (PubMed:7225365). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with PIFO. Interacts with DIAPH1 (By similarity). Interacts with MX1 (By similarity). May interact with RNABP10 (By similarity). Interacts with CFAP157 (By similarity). Nascent tubulin polypeptide interacts (via beta-tubulin MREI motif) with TTC5/STRAP; this interaction results in tubulin mRNA-targeted degradation (By similarity).
messages: Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:7225365). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:7225365). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:7225365).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:LOC100156937
gene id: 9823:LOC100156937
uniprot id: A0A480K1G1
uniprot id: A0A4X1VJL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:FAM19A3
gene id: 9823:FAM19A3
uniprot id: A0A4X1T5X2
uniprot id: A0A5G2RD17
names: Similarity
messages: Belongs to the TAFA family.

9823:HSD3B7
gene id: 9823:HSD3B7
uniprot id: A0A286ZXF3
uniprot id: A0A480VXZ1
uniprot id: A0A8D1UNE6
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9823:SLC5A8
gene id: 9823:SLC5A8
uniprot id: A0A4X1SYJ9
uniprot id: F1SRH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9823:DCAF13
gene id: 9823:DCAF13
uniprot id: A0A480V443
uniprot id: A0A8D1RCH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

9823:ETFRF1
gene id: 9823:ETFRF1
uniprot id: A0A287BTM9
uniprot id: A0A4X1VK04
names: Similarity
messages: Belongs to the complex I LYR family.

9823:HEBP1
gene id: 9823:HEBP1
uniprot id: Q5ISC6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEBP family.
messages: Cytoplasm
messages: Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
messages: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity).
messages: Monomer.

9823:DHDH
gene id: 9823:DHDH
uniprot id: A0A481C3F0
uniprot id: Q9TV69
names: Activity Regulation
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the Gfo/Idh/MocA family.
messages: Homodimer.
messages: Liver, lens, spleen, kidney and small intestine.
messages: Strongly inhibited by isoascorbic acid, 4-hydroxyacetophenone and chloromercuriphenylsulphonate. Stimulated by various salts.

9823:ATP6V1G1
gene id: 9823:ATP6V1G1
uniprot id: A0A287AKZ9
uniprot id: A0A4X1UZN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9823:DIO1
gene id: 9823:DIO1
uniprot id: Q6QN13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iodothyronine deiodinase family.
messages: Endoplasmic reticulum membrane
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

9823:RIPOR3
gene id: 9823:RIPOR3
uniprot id: A0A5K1UU14
uniprot id: A0A8D1UFL5
names: Similarity
messages: Belongs to the RIPOR family.

9823:CPNE3
gene id: 9823:CPNE3
uniprot id: A0A4X1UBQ4
uniprot id: F1RXD5
names: Similarity
messages: Belongs to the copine family.

9823:GALNS
gene id: 9823:GALNS
uniprot id: Q8WNQ7
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Homodimer.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9823:JPT2
gene id: 9823:JPT2
uniprot id: I7KJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9823:NIT2
gene id: 9823:NIT2
uniprot id: A0A4X1UWI9
uniprot id: F1SKY2
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9823:CLDN18
gene id: 9823:CLDN18
uniprot id: A0A4X1TI41
uniprot id: C3VMW4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:CD47
gene id: 9823:CD47
uniprot id: A8VKH9
uniprot id: Q9GKE8
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Membrane
messages: Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2 (By similarity). Interacts with THBS1 and fibrinogen.
messages: Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Plays an important role in memory formation and synaptic plasticity in the hippocampus. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. May play a role in memory formation (By similarity). Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.
messages: Widely expressed, detected in kidney, liver, platelets, thymus, spleen, macrophages, bone marrow and peripheral blood mononuclear cells.

9823:EMC6
gene id: 9823:EMC6
uniprot id: A0A4X1UAQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:EEF1A1
gene id: 9823:EEF1A1
uniprot id: A0A4X1U102
uniprot id: Q0PY11
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9823:HYAL3
gene id: 9823:HYAL3
uniprot id: A0A480XR39
uniprot id: A0A4X1SKF7
uniprot id: A0A4X1SLH4
uniprot id: Q6RHW2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.
messages: Highly expressed in bladder, spleen and liver. Expressed at low levels in the kidney.
messages: Membrane
messages: N-glycosylated.
messages: Secreted
messages: acrosome

9823:HOGA1
gene id: 9823:HOGA1
uniprot id: A0A4X1UAM4
uniprot id: F1S8X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9823:ESRP1
gene id: 9823:ESRP1
uniprot id: A0A286ZV42
uniprot id: A0A480JEY8
uniprot id: A0A4X1U0A3
uniprot id: A0A5G2R387
uniprot id: A0A8D1P4H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus

9823:SLC25A13
gene id: 9823:SLC25A13
uniprot id: A0A4X1TR24
uniprot id: A0A8D1VA14
uniprot id: M3VH80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9823:RAB11FIP4
gene id: 9823:RAB11FIP4
uniprot id: A0A287ALE5
uniprot id: A0A4X1TL09
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

9823:AGO1
gene id: 9823:AGO1
uniprot id: A0A8D0ZC34
uniprot id: D9YJ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9823:TMEM41B
gene id: 9823:TMEM41B
uniprot id: A0A286ZID7
uniprot id: A0A8D1JS71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9823:NSA2
gene id: 9823:NSA2
uniprot id: A0A4X1SRK5
uniprot id: A0A5G2QRK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9823:LHX9
gene id: 9823:LHX9
uniprot id: A0A287AJK3
uniprot id: A0A480K424
uniprot id: A0A4X1SPP8
uniprot id: A0A8D0K3A2
uniprot id: A0A8D0N9S0
uniprot id: F1S5F5
names: Subcellular Location Annotation
messages: Nucleus

9823:MMP14
gene id: 9823:MMP14
uniprot id: Q9XT90
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.
messages: Highly expressed in developing tooth tissues.
messages: Interacts (via C-terminal cytoplasmic tail) with BST2. Interacts with DLL1; inhibits DLL1-induced Notch signaling.
messages: Melanosome
messages: Membrane
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: Tyrosine phosphorylated by PKDCC/VLK.

9823:RPS6KB1
gene id: 9823:RPS6KB1
uniprot id: A0A481C7T7
uniprot id: A0A4X1STL0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9823:ERLEC1
gene id: 9823:ERLEC1
uniprot id: A0A287ARF1
uniprot id: A0A287B0P2
uniprot id: A0A8D0TM32
uniprot id: A0A8D1VYY1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9823:KREMEN1
gene id: 9823:KREMEN1
uniprot id: A0A480W7P4
uniprot id: A0A8D1YCT1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

9823:ECH1
gene id: 9823:ECH1
uniprot id: Q3Y5G5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9823:FTH1
gene id: 9823:FTH1
uniprot id: A0A287AL10
uniprot id: A0A4X1VGP9
uniprot id: P19130
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with Porcine circovirus 2 ORF4 protein.
messages: (Microbial infection) Interacts with classical swine fever virus protein NS4B.
messages: (Microbial infection) Is unable to assume its function upon interaction with viral proteins, thereby increasing Fe concentration in the cytoplasm. This would inhibit the accumulation of reactive oxygen in host cells, leading to reduced apoptosis and increasing the survival of virus infected cell.
messages: Belongs to the ferritin family.
messages: Cytoplasm
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9823:PDSS1
gene id: 9823:PDSS1
uniprot id: A0A8D1D4I1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9823:AGPAT3
gene id: 9823:AGPAT3
uniprot id: A0A4X1TE98
uniprot id: B8XTR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9823:GRK5
gene id: 9823:GRK5
uniprot id: A0A4X1SV29
uniprot id: F1S417
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9823:MYMK
gene id: 9823:MYMK
uniprot id: A0A4X1SZ95
uniprot id: I3LUN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9823:ANGPT1
gene id: 9823:ANGPT1
uniprot id: Q9BDY8
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity).
messages: Glycosylated.
messages: Secreted

9823:LYRM1
gene id: 9823:LYRM1
uniprot id: A0A480UD68
uniprot id: A0A8D0Z678
uniprot id: A0A8D2A5P9
names: Similarity
messages: Belongs to the complex I LYR family.

9823:B4GALT7
gene id: 9823:B4GALT7
uniprot id: A0A4X1VRF9
uniprot id: D1H0P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9823:ZNF174
gene id: 9823:ZNF174
uniprot id: A0A4X1VNH3
uniprot id: A0A5G2R6E2
names: Subcellular Location Annotation
messages: Nucleus

9823:TUB
gene id: 9823:TUB
uniprot id: A0A8D1K5X5
uniprot id: F1RNI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9823:TMEM167A
gene id: 9823:TMEM167A
uniprot id: A0A4X1T901
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

9823:LTB4R
gene id: 9823:LTB4R
uniprot id: A0A4X1SRI3
uniprot id: I3LE30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:KEF22 p01
gene id: 9823:KEF22_p01
uniprot id: A0A4X1WDE0
uniprot id: P24964
uniprot id: Q1HBG9
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9823:TMEM170A
gene id: 9823:TMEM170A
uniprot id: A0A4X1SX53
uniprot id: F1S453
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9823:GBA
gene id: 9823:GBA
uniprot id: A0A4X1W0Q8
uniprot id: F1RGS2
uniprot id: Q70KH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose. Plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol. GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide. Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers. Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside.
messages: Interacts with saposin-C. Interacts with SCARB2. Interacts with TCP1. Interacts with GRN; this interaction prevents aggregation of GBA1-SCARB2 complex via interaction with HSPA1A upon stress (By similarity).
messages: Lysosome membrane

9823:KIF18A
gene id: 9823:KIF18A
uniprot id: A0A8D0T2F9
uniprot id: F1SGM6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:COX7A2
gene id: 9823:COX7A2
uniprot id: A1XQV6
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9823:GFRA3
gene id: 9823:GFRA3
uniprot id: A0A480PSU1
names: Similarity
messages: Belongs to the GDNFR family.

9823:STRIP2
gene id: 9823:STRIP2
uniprot id: A0A4X1VZZ4
names: Similarity
messages: Belongs to the STRIP family.

9823:CD70
gene id: 9823:CD70
uniprot id: Q3ZDR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
messages: Homotrimer.
messages: Membrane
messages: N-glycosylated.

9823:LOC100157987
gene id: 9823:LOC100157987
uniprot id: A0A4X1TM30
uniprot id: F1RKD3
names: Subcellular Location Annotation
messages: Nucleus

9823:HOXD13
gene id: 9823:HOXD13
uniprot id: A0A4X1UKC8
uniprot id: F1RZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9823:ATP6V1H
gene id: 9823:ATP6V1H
uniprot id: A0A8D0PCE0
uniprot id: F1RSG6
uniprot id: Q9TVC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with AP2M1 (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.
messages: clathrin-coated vesicle membrane

9823:TMPRSS7
gene id: 9823:TMPRSS7
uniprot id: A0A5G2QNS7
uniprot id: A0A8D1IJE7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:IL17F
gene id: 9823:IL17F
uniprot id: A0A4X1TI16
uniprot id: K7GQP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9823:MAP2K6
gene id: 9823:MAP2K6
uniprot id: A0A4X1SME1
uniprot id: A0A5K1UKA4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:SEPT3
gene id: 9823:SEPT3
uniprot id: A0A173G6G5
uniprot id: A0A8D0MSK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:LOC100524022
gene id: 9823:LOC100524022
uniprot id: A0A4X1W6A9
names: Similarity
messages: Belongs to the intermediate filament family.

9823:RPLP2
gene id: 9823:RPLP2
uniprot id: A0A287B7U0
uniprot id: A0A4X1VXC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9823:AGTPBP1
gene id: 9823:AGTPBP1
uniprot id: A0A286ZZU0
uniprot id: F1S4H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9823:ESR2
gene id: 9823:ESR2
uniprot id: Q9XSW2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with UBE1C and AKAP13. Interacts with DNTTIP2. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with DNAAF4. Interacts with PRMT2. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with RBM39, in the presence of estradiol (E2).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
messages: Nucleus
messages: Phosphorylation at Ser-84 and Ser-102 recruits NCOA1.

9823:PDP1
gene id: 9823:PDP1
uniprot id: A0A287A5F9
uniprot id: A0A4X1U5W8
uniprot id: A0A4X1U8I2
uniprot id: A0A4X1U8P1
uniprot id: F1RY43
names: Similarity
messages: Belongs to the PP2C family.

9823:FAM212B
gene id: 9823:FAM212B
uniprot id: A0A5G2QF54
uniprot id: A0A8D0ZQB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9823:ETF1
gene id: 9823:ETF1
uniprot id: A0A4X1V8F0
uniprot id: A0A8D0HZG3
uniprot id: F2Z505
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9823:PTGIS
gene id: 9823:PTGIS
uniprot id: A0A8D0ZAZ2
uniprot id: F1SBE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
messages: Endoplasmic reticulum membrane

9823:MAN2B2
gene id: 9823:MAN2B2
uniprot id: Q28949
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.
messages: Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida.
messages: Processed into a 27 kDa fragment localized on the equatorial segment and the apical rim of the head of mature sperm.
messages: Secreted
messages: Specific to the caput and corpus of the epididymis.

9823:PET100
gene id: 9823:PET100
uniprot id: A1XQS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PET100 family.
messages: Interacts with COX7A2.
messages: Membrane
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial complex IV assembly.

9823:NRM
gene id: 9823:NRM
uniprot id: A0A4X1VI68
uniprot id: A0A5S6GV83
uniprot id: Q767L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9823:SUPT4H1
gene id: 9823:SUPT4H1
uniprot id: A0A480VIE8
uniprot id: A0A4X1SL69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9823:SH2B3
gene id: 9823:SH2B3
uniprot id: A0A8D1D8T9
uniprot id: F1RMZ2
names: Similarity
messages: Belongs to the SH2B adapter family.

9823:MTRF1
gene id: 9823:MTRF1
uniprot id: F1RJ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9823:LOC100157017
gene id: 9823:LOC100157017
uniprot id: A0A287A5X0
uniprot id: A0A287BKR9
uniprot id: A0A4X1SD82
uniprot id: A0A8D1JSD5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9823:LOC100154647
gene id: 9823:LOC100154647
uniprot id: A0A480DLH8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:LOC100739859
gene id: 9823:LOC100739859
uniprot id: A0A8D0LEC0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ACOX1
gene id: 9823:ACOX1
uniprot id: A7J0B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9823:FAM26D
gene id: 9823:FAM26D
uniprot id: A0A4X1V2M0
uniprot id: F1RX92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9823:GTF2I
gene id: 9823:GTF2I
uniprot id: A0A480HY11
uniprot id: A0A480I447
uniprot id: A0A480SDW2
uniprot id: A0A480WNN3
uniprot id: A0A4X1SK02
uniprot id: A0A4X1SKK1
uniprot id: A0A5K1VLI8
uniprot id: A0A8D1AB35
uniprot id: A0A8D1E3Z3
uniprot id: A0A8D1VYM6
uniprot id: A0A8D1XB59
uniprot id: F1RJL2
names: Subcellular Location Annotation
messages: Nucleus

9823:CD109
gene id: 9823:CD109
uniprot id: A0A8D1AXL6
uniprot id: K7GKY0
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

9823:AP4B1
gene id: 9823:AP4B1
uniprot id: A0A4X1T215
uniprot id: F1SBR2
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9823:SLC25A24
gene id: 9823:SLC25A24
uniprot id: A0A8D1H5U9
uniprot id: B2MUB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9823:LOC106510297
gene id: 9823:LOC106510297
uniprot id: A0A4X1W9V6
uniprot id: F1SR41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:POLR2H
gene id: 9823:POLR2H
uniprot id: A0A4X1UHM0
uniprot id: A0A4X1ULF2
uniprot id: A0A5G2R6C5
uniprot id: I3LCB2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9823:RAB11A
gene id: 9823:RAB11A
uniprot id: Q52NJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with RAB11FIP5 (By similarity). Interacts with STXBP6 (By similarity). Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39. Interacts with EXOC6 in a GTP-dependent manner. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5. Interacts (GDP-bound form) with RELCH (By similarity). Found in a complex composed of RELCH, OSBP1 and RAB11A (By similarity). Interacts with DEF6 (By similarity).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity).
messages: phagosome

9823:BET1L
gene id: 9823:BET1L
uniprot id: A0A4X1VTQ2
uniprot id: F1RGD1
names: Subcellular Location Annotation
messages: Membrane

9823:SNRPD3
gene id: 9823:SNRPD3
uniprot id: A0A4X1V3C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9823:ANAPC10
gene id: 9823:ANAPC10
uniprot id: A0A5G2Q7B5
uniprot id: A0A8D0Q8K0
uniprot id: D5L7X1
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9823:NR2F1
gene id: 9823:NR2F1
uniprot id: A0A4X1TCJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:CD9
gene id: 9823:CD9
uniprot id: Q8WMQ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (By similarity). Interacts with integrin ITGA6:ITGB1; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). Part of integrin-tetraspanin complexes composed of CD81, beta-1 and beta-2 integrins in the membrane of monocyte/macrophages (By similarity). Interacts with CD63; identified in a complex with CD63 and ITGB3. Associates with CR2/CD21 and with PTGFRN/CD9P1. Part of a complex composed of CD9, CD81, PTGFRN and IGSF8 (By similarity). Interacts directly with IGSF8. Interacts with PDPN; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Interacts (on T cell side) with CD81 at immunological synapses between antigen-presenting cells and T cells (By similarity).
messages: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity).
messages: Membrane
messages: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion.
messages: Ubiquitous.
messages: extracellular exosome

9823:ABHD16A
gene id: 9823:ABHD16A
uniprot id: B9TSQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

9823:NUTF2
gene id: 9823:NUTF2
uniprot id: A0A4X1UHL0
uniprot id: F1S2K3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9823:CREB1
gene id: 9823:CREB1
uniprot id: Q5I240
names: Subcellular Location Annotation
messages: Nucleus

9823:FAM83F
gene id: 9823:FAM83F
uniprot id: A0A480E6T4
uniprot id: A0A8D1XPV8
names: Similarity
messages: Belongs to the FAM83 family.

9823:ACLY
gene id: 9823:ACLY
uniprot id: A7UIU7
uniprot id: H9BYW4
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9823:SRPK3
gene id: 9823:SRPK3
uniprot id: B8Y466
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily.
messages: Highly expressed in skeletal muscle, heart, uterus and parorchis. Weakly expressed in brain, stomach, small intestine and ovary.
messages: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).

9823:FAM98B
gene id: 9823:FAM98B
uniprot id: A0A8D1PRK4
uniprot id: F1SS16
names: Similarity
messages: Belongs to the FAM98 family.

9823:TRPC4
gene id: 9823:TRPC4
uniprot id: C0JJ16
names: Subcellular Location Annotation
messages: Membrane

9823:F11R
gene id: 9823:F11R
uniprot id: A0A4X1VMT6
uniprot id: B2ZI35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9823:PMVK
gene id: 9823:PMVK
uniprot id: Q29081
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.
messages: Monomer.
messages: Was originally thought to be located in the peroxisome. However, was later shown to be cytosolic.
messages: cytosol

9823:LMBR1L
gene id: 9823:LMBR1L
uniprot id: A0A4X1WCW1
uniprot id: F1SJ09
names: Similarity
messages: Belongs to the LIMR family.

9823:PSMA3
gene id: 9823:PSMA3
uniprot id: A0A4X1W7L8
uniprot id: F1SSL6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9823:NARFL
gene id: 9823:NARFL
uniprot id: A0A480TWG4
uniprot id: A0A4X1SX73
names: Similarity
messages: Belongs to the NARF family.

9823:PSMB6
gene id: 9823:PSMB6
uniprot id: A0A4X1UYL6
uniprot id: F1RFV5
uniprot id: G3DRF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:SOX2
gene id: 9823:SOX2
uniprot id: B1Q0D1
names: Subcellular Location Annotation
messages: Nucleus

9823:RPL26L1
gene id: 9823:RPL26L1
uniprot id: B7TJ03
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9823:GDF2
gene id: 9823:GDF2
uniprot id: A0A8D1NGR3
names: Similarity
messages: Belongs to the TGF-beta family.

9823:ALDH9A1
gene id: 9823:ALDH9A1
uniprot id: A0A8D0RIX3
uniprot id: F1S232
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9823:STRA6
gene id: 9823:STRA6
uniprot id: A0A8D0SFA5
uniprot id: F1SIE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SARDH
gene id: 9823:SARDH
uniprot id: A0A287B4Z6
names: Similarity
messages: Belongs to the GcvT family.

9823:MTTP
gene id: 9823:MTTP
uniprot id: A0A480UDD3
uniprot id: Q865F1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (By similarity). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Heterodimer; heterodimerizes with the protein disulfide isomerase (P4HB/PDI). Interacts with APOB (By similarity). Interacts with PRAP1 (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:CYB5B
gene id: 9823:CYB5B
uniprot id: A0A480PFJ9
uniprot id: A0A8D0IUJ8
names: Similarity
messages: Belongs to the cytochrome b5 family.

9823:ZBED9
gene id: 9823:ZBED9
uniprot id: A0A8D0V179
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100525684
gene id: 9823:LOC100525684
uniprot id: A0A4X1UZD7
uniprot id: A0A5G2RBM4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:AKT2
gene id: 9823:AKT2
uniprot id: A0A8D0Y1T1
uniprot id: G9BWQ2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9823:LOC100525034
gene id: 9823:LOC100525034
uniprot id: A0A4X1UYT5
uniprot id: F1SCA5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:VPS26A
gene id: 9823:VPS26A
uniprot id: A0A4X1TIN3
uniprot id: A0A5G2R334
uniprot id: A0A5G2R839
names: Similarity
messages: Belongs to the VPS26 family.

9823:IFN-ALPHA-17
gene id: 9823:IFN-ALPHA-17
uniprot id: A0A4X1WCB6
uniprot id: C8CKA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:SERPINE2
gene id: 9823:SERPINE2
uniprot id: A0A4X1U5V7
uniprot id: Q8WNW8
names: Similarity
messages: Belongs to the serpin family.

9823:TMOD2
gene id: 9823:TMOD2
uniprot id: A0A287BG70
uniprot id: A0A4X1T3P0
uniprot id: A0A8D0QY88
names: Subcellular Location Annotation
messages: cytoskeleton

9823:LOC100738684
gene id: 9823:LOC100738684
uniprot id: A0A286ZJU5
uniprot id: A0A8D0RBI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9823:LOC100624329
gene id: 9823:LOC100624329
uniprot id: A0A8D0IR41
names: Subcellular Location Annotation
messages: Nucleus

9823:PLET1
gene id: 9823:PLET1
uniprot id: Q7YQE5
names: Caution
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: For human, rat and golden hamster orthologs, a GPI-anchor has been predicted. However, in the case of pig and bovine, no GPI-anchor motifs have been detected, but it does not rule out the possibility of a GPI-anchor instead of a single-pass type I membrane protein.
messages: Highly expressed in placenta.
messages: Membrane
messages: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).

9823:GAD2
gene id: 9823:GAD2
uniprot id: P48321
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the production of GABA.
messages: Cytoplasmic vesicle
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Palmitoylated; which is required for presynaptic clustering.
messages: Phosphorylated; which does not affect kinetic parameters or subcellular location.
messages: Presynaptic cell membrane
messages: cytosol

9823:ISCU
gene id: 9823:ISCU
uniprot id: A0A4X1SPQ0
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

9823:ACP5
gene id: 9823:ACP5
uniprot id: P09889
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 2 iron ions per subunit.
messages: Secreted
messages: Uteroferrin is a phosphoprotein phosphatase, synthesized in response to progesterone. It appears to function in transplacental transport of iron in pig.

9823:WNT5A
gene id: 9823:WNT5A
uniprot id: A0A287A1J0
uniprot id: A0A4X1VKW8
uniprot id: A0A4X1VLY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:ATP2A2
gene id: 9823:ATP2A2
uniprot id: A0A480M6X9
uniprot id: P11607
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Detected in heart left ventricle (at protein level) (PubMed:30777856). Isoform 2 is highly expressed in heart and slow twitch skeletal muscle. Isoform 1 is widely expressed.
messages: Endoplasmic reticulum membrane
messages: Has different conformational states with differential Ca2+ affinity. The E1 conformational state (active form) shows high Ca(2+) affinity, while the E2 state exhibits low Ca(2+) affinity. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Inhibited by sarcolipin (SLN) and myoregulin (MRLN). The inhibition is blocked by VMP1 (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Stabilizes SERCA2 in its E2 state (By similarity).
messages: Interacts with TRAM2 (via C-terminus).
messages: Interacts with sarcolipin (SLN); the interaction inhibits ATP2A2 Ca(2+) affinity. Interacts with phospholamban (PLN); the interaction inhibits ATP2A2 Ca(2+) affinity (By similarity). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Interacts with HAX1 (By similarity). Interacts with S100A8 and S100A9 (By similarity). Interacts with SLC35G1 and STIM1. Interacts with TMEM203 (By similarity). Interacts with TMEM64 and PDIA3 (By similarity). Interacts with TMX2 (By similarity). Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with ULK1 (By similarity). Interacts with S100A1 in a Ca(2+)-dependent manner (By similarity). Interacts with TUNAR (By similarity).
messages: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity.
messages: PLN and SLN both have a single transmembrane helix; both occupy a similar binding site that is situated between the ATP2A2 transmembrane helices.
messages: Sarcoplasmic reticulum membrane
messages: Serotonylated on Gln residues by TGM2 in response to hypoxia, leading to its inactivation.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes.

9823:LOC100515171
gene id: 9823:LOC100515171
uniprot id: A0A286ZLY4
uniprot id: A0A287AUP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9823:CRK
gene id: 9823:CRK
uniprot id: B6DX82
names: Similarity
messages: Belongs to the CRK family.

9823:CLVS1
gene id: 9823:CLVS1
uniprot id: A0A4X1V3N5
uniprot id: F1RT89
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9823:C1S
gene id: 9823:C1S
uniprot id: Q69DK8
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain (By similarity).
messages: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity).
messages: Inhibited by SERPING1.
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

9823:MAP3K8
gene id: 9823:MAP3K8
uniprot id: A0A287AAP3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9823:ACSM2B
gene id: 9823:ACSM2B
uniprot id: A0A8D0YVA5
uniprot id: F1RPB0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:PPYR1
gene id: 9823:PPYR1
uniprot id: A0A4X1VG83
uniprot id: O97505
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9823:TG
gene id: 9823:TG
uniprot id: F1RRV3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:7021557). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (PubMed:7021557). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity).
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Expressed in thyroid epithelial cells.
messages: Iodinated on tyrosine residues by TPO (PubMed:12325367). There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-24 is coupled to donor Tyr-149 or Tyr-234, acceptor Tyr-2500 is coupled to donor Tyr-2467, acceptor Tyr-2690 in monomer 1 is coupled to donor Tyr-2690 in monomer 2 and acceptor Tyr-1241 in monomer 1 is coupled to donor Tyr-108 in monomer 2 (By similarity).
messages: Monomer (By similarity). Homodimer (via ChEL region); occurs in the endoplasmic reticulum and is required for export to the Golgi apparatus (By similarity). Homooligomer; disulfide-linked; stored in this form in the thyroid follicle lumen (By similarity).
messages: Secreted
messages: Sulfated tyrosines are desulfated during iodination.
messages: The cholinesterase-like (ChEL) region is required for dimerization and export from the endoplasmic reticulum.
messages: The cholinesterase-like (ChEL) region lacks the Ser residue of the catalytic triad suggesting that it has no esterase activity.
messages: Undergoes sequential proteolysis by cathepsins to release thyroxine (T4) and triiodothyronine (T3) hormones (By similarity). In the thyroid follicle lumen, cross-linked TG (storage form) is solubilized by limited proteolysis mediated by cathepsins CTSB and/or CTSL (By similarity). Partially cleaved TG is further processed by CTSK/cathepsin K and/or CTSL resulting in the release of T4 (PubMed:11082042). Following endocytosis, further processing occurs leading to the release of T3 and more T4 hormones (By similarity).

9823:GJB1
gene id: 9823:GJB1
uniprot id: A0A8D0LP06
uniprot id: F1RSW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9823:USH1G
gene id: 9823:USH1G
uniprot id: A0A4X1SGT8
uniprot id: F1RVV1
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9823:ITGA4
gene id: 9823:ITGA4
uniprot id: A0A8D1BHC3
uniprot id: K9IVL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9823:SFRP2
gene id: 9823:SFRP2
uniprot id: A0A4X1STF2
uniprot id: F1RX31
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:AP1B1
gene id: 9823:AP1B1
uniprot id: A0A287B5G9
uniprot id: A0A480J4P8
uniprot id: A0A480UCY7
uniprot id: A0A4X1VG84
uniprot id: A0A4X1VG89
uniprot id: A0A8D0Z3T0
uniprot id: F1RFI2
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9823:NME6
gene id: 9823:NME6
uniprot id: A0A8D1RAL0
uniprot id: F1SKM8
names: Similarity
messages: Belongs to the NDK family.

9823:DMRTA1
gene id: 9823:DMRTA1
uniprot id: A0A4X1WCD4
uniprot id: F1SNK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9823:TNNT3
gene id: 9823:TNNT3
uniprot id: Q75NG9
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9823:ADPRHL1
gene id: 9823:ADPRHL1
uniprot id: A0A4X1U197
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9823:TMEM88B
gene id: 9823:TMEM88B
uniprot id: A0A287B8A0
uniprot id: A0A4X1W8Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9823:RIPOR1
gene id: 9823:RIPOR1
uniprot id: A0A287AA53
uniprot id: A0A4X1UL60
uniprot id: A0A4X1UMG9
uniprot id: A0A8D1Q0K3
names: Similarity
messages: Belongs to the RIPOR family.

9823:TIRAP
gene id: 9823:TIRAP
uniprot id: A0A287A8A9
uniprot id: A0A8D1DAN0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

9823:ZPBP
gene id: 9823:ZPBP
uniprot id: Q29108
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Expressed in testis. Detected in sperm cells.
messages: N-glycosylated.
messages: Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization.
messages: Secreted
messages: acrosome
messages: acrosome membrane

9823:NPEPPS
gene id: 9823:NPEPPS
uniprot id: A0A480TTS7
uniprot id: A0A4X1UNB9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9823:BCL9L
gene id: 9823:BCL9L
uniprot id: A0A8D2A3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9823:PHC1
gene id: 9823:PHC1
uniprot id: A0A8D1VZJ0
names: Subcellular Location Annotation
messages: Nucleus

9823:LDLRAD4
gene id: 9823:LDLRAD4
uniprot id: A0A4X1VTW1
uniprot id: I3LQ52
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:BMS1
gene id: 9823:BMS1
uniprot id: A0A4X1U1W8
names: Subcellular Location Annotation
messages: nucleolus

9823:LOC100156148
gene id: 9823:LOC100156148
uniprot id: A0A4X1VKS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:AIDA
gene id: 9823:AIDA
uniprot id: A0A4X1TLZ0
uniprot id: F1S9H0
names: Similarity
messages: Belongs to the AIDA family.

9823:FBXL5
gene id: 9823:FBXL5
uniprot id: A0A8D1CBI3
uniprot id: F1S5E2
names: Subcellular Location Annotation
messages: perinuclear region

9823:SH3KBP1
gene id: 9823:SH3KBP1
uniprot id: A0A4X1V8Z6
uniprot id: A0A8D0T9S2
names: Subcellular Location Annotation
messages: focal adhesion

9823:DNTT
gene id: 9823:DNTT
uniprot id: A0A4X1UFW0
uniprot id: F1SBG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

9823:SPAG11
gene id: 9823:SPAG11
uniprot id: Q1RLJ2
names: Subcellular Location Annotation
messages: Secreted

9823:PNPLA6
gene id: 9823:PNPLA6
uniprot id: A0A4X1VPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:GPER1
gene id: 9823:GPER1
uniprot id: A0A8D0ZN56
uniprot id: I3LSZ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:LRP3
gene id: 9823:LRP3
uniprot id: A0A8D1JEJ1
uniprot id: A0A8D1P1T5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:OOEP
gene id: 9823:OOEP
uniprot id: A0A4X1VKC4
uniprot id: E2IUK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDC1 family.
messages: Cytoplasm
messages: Nucleus

9823:METTL8
gene id: 9823:METTL8
uniprot id: A0A8D1YWM1
uniprot id: F1S1U3
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9823:CDR2L
gene id: 9823:CDR2L
uniprot id: A0A4X1V3T1
uniprot id: F1RVV7
names: Similarity
messages: Belongs to the CDR2 family.

9823:LOC106508617
gene id: 9823:LOC106508617
uniprot id: A0A4X1TUW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:E2F5
gene id: 9823:E2F5
uniprot id: A0A4X1UDJ9
uniprot id: F1RXB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9823:ST8SIA4
gene id: 9823:ST8SIA4
uniprot id: A0A4X1TQ81
uniprot id: Q30E19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:FGD2
gene id: 9823:FGD2
uniprot id: A0A8D0JPZ7
names: Subcellular Location Annotation
messages: cytoskeleton

9823:MED17
gene id: 9823:MED17
uniprot id: A0A287BDX9
uniprot id: A0A4X1TVK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:SDHC
gene id: 9823:SDHC
uniprot id: D0VWV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Detected in heart muscle (at protein level).
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane
messages: The heme b is bound between the two transmembrane subunits SDHC and SDHD.

9823:RNF182
gene id: 9823:RNF182
uniprot id: A0A480DHP1
uniprot id: A0A8D1E796
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9823:SAT1
gene id: 9823:SAT1
uniprot id: Q28999
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Also acts on 1,3-diaminopropane and 1,5-diaminopentane.
messages: Homodimer.
messages: cytosol

9823:PLCD1
gene id: 9823:PLCD1
uniprot id: A0A480F1A1
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9823:SLC2A4
gene id: 9823:SLC2A4
uniprot id: B2LWF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9823:VGLL3
gene id: 9823:VGLL3
uniprot id: A0A4X1UMY1
uniprot id: A0A4X1UNS4
uniprot id: A0A5G2QGL6
uniprot id: A0A8D0PJX7
uniprot id: B8Y4S7
uniprot id: B8Y4S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9823:FAM234A
gene id: 9823:FAM234A
uniprot id: A0A8D1L062
uniprot id: F1RGX2
names: Similarity
messages: Belongs to the FAM234 family.

9823:PGM2L1
gene id: 9823:PGM2L1
uniprot id: A0A286ZWR7
uniprot id: A0A4X1UQV2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9823:LOC100155138
gene id: 9823:LOC100155138
uniprot id: A0A8D0MRN3
uniprot id: F1RK98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9823:IL4R
gene id: 9823:IL4R
uniprot id: Q863Z5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
messages: Membrane
messages: On IL4 binding, phosphorylated on C-terminal tyrosine residues.
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling. Interacts with JAK3. Interacts with CLM1.

9823:LGALSL
gene id: 9823:LGALSL
uniprot id: A0A5G2RJ56
uniprot id: A0A8D0V1W3
uniprot id: A0A8D1TPN1
uniprot id: I3L8J2
names: Function
messages: Does not bind lactose, and may not bind carbohydrates.

9823:LOC100156741
gene id: 9823:LOC100156741
uniprot id: A0A286ZJQ0
uniprot id: A0A8D1E1K4
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:CEP57L1
gene id: 9823:CEP57L1
uniprot id: A0A5G2QJE9
uniprot id: A0A8D0LRF4
uniprot id: F1RT09
names: Similarity
messages: Belongs to the translokin family.

9823:RAP2B
gene id: 9823:RAP2B
uniprot id: Q06AU2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by the guanine nucleotide-exchange factors RAPGEF3 and RAPGEF4 in a cAMP-dependent manner. Nucleotide exchange is also specifically stimulated by RAPGEF5, RASGEF1A and RASGEF1B (By similarity).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Interacts (GTP-bound form) with RUNDC3A. Interacts with PLCE1. Interacts with ARHGAP29, SGSM1, SGSM2 and SGSM3. Interacts (GTP-bound form preferentially) with TNIK (via the CNH domain); the interaction is direct and recruits RAP2A to the E3 ubiquitin ligase NEDD4. Interacts with MINK1. Interacts (GTP-bound form preferentially) with MAP4K4. Interacts with cytoskeletal actin. Interacts with RGS14; the interaction is GTP-dependent (By similarity).
messages: Midbody
messages: Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity).
messages: The effector domain mediates the interaction with RUNDC3A.
messages: Ubiquitinated; undergoes 'Lys-63' monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A (By similarity).

9823:IBSP
gene id: 9823:IBSP
uniprot id: K7GP14
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9823:TLL2
gene id: 9823:TLL2
uniprot id: A0A287AKC2
uniprot id: A0A4X1UGP7
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:PLEKHA8
gene id: 9823:PLEKHA8
uniprot id: A0A480MFC9
uniprot id: A0A8D0ZEJ3
names: Subcellular Location Annotation
messages: Membrane
messages: trans-Golgi network membrane

9823:RIMKLB
gene id: 9823:RIMKLB
uniprot id: A0A480EQP4
uniprot id: A0A4X1U2S6
names: Similarity
messages: Belongs to the RimK family.

9823:OPALIN
gene id: 9823:OPALIN
uniprot id: A0A287ATF4
uniprot id: A0A287B0U7
uniprot id: A0A4X1UFS3
uniprot id: A0A4X1UH25
uniprot id: A0A4X1UH48
uniprot id: Q29102
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Cytoplasm
messages: Membrane
messages: Specifically expressed in brain.

9823:ENTPD3
gene id: 9823:ENTPD3
uniprot id: A0A480S040
uniprot id: A0A8D1XV51
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9823:APOC2
gene id: 9823:APOC2
uniprot id: A0A4X1W295
uniprot id: D3Y264
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
messages: Secreted

9823:INPP5J
gene id: 9823:INPP5J
uniprot id: A0A8D1PZW0
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9823:ADAM9
gene id: 9823:ADAM9
uniprot id: A0A4X1VWW2
uniprot id: F1RZL4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:HSPB8
gene id: 9823:HSPB8
uniprot id: A0A4X1TV19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9823:GTF2A2
gene id: 9823:GTF2A2
uniprot id: A0A480PU90
uniprot id: A0A4X1TRI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9823:B3GALT2
gene id: 9823:B3GALT2
uniprot id: A0A4X1TRV1
uniprot id: F1SAB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:DYDC1
gene id: 9823:DYDC1
uniprot id: A0A4X1SH76
names: Similarity
messages: Belongs to the dpy-30 family.

9823:LOC100524517
gene id: 9823:LOC100524517
uniprot id: A0A8D1JBG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9823:RIOK1
gene id: 9823:RIOK1
uniprot id: A0A8D1VCF9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9823:TAS1R3
gene id: 9823:TAS1R3
uniprot id: A0A4X1W3A9
uniprot id: F1RJE6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:SQSTM1
gene id: 9823:SQSTM1
uniprot id: A0A480K284
uniprot id: A0A8D0YZY4
uniprot id: A0A8D1YAK0
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9823:DDX3X
gene id: 9823:DDX3X
uniprot id: A0A8D0ZIA5
uniprot id: F1RX16
uniprot id: F4ZS18
names: Similarity
messages: Belongs to the DEAD box helicase family.

9823:TLCD1
gene id: 9823:TLCD1
uniprot id: A0A286ZY47
uniprot id: A0A4X1TRJ7
names: Subcellular Location Annotation
messages: Membrane

9823:TEAD4
gene id: 9823:TEAD4
uniprot id: B7SFP7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

9823:RPL24
gene id: 9823:RPL24
uniprot id: A0A4X1SH42
uniprot id: F2Z5Q2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9823:B3GALT4
gene id: 9823:B3GALT4
uniprot id: A0A4X1TE92
uniprot id: F1RZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:LOC100523167
gene id: 9823:LOC100523167
uniprot id: A0A5G2QSG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SNRPG
gene id: 9823:SNRPG
uniprot id: A0A4X1W3U9
uniprot id: F2Z5V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9823:GRAMD1C
gene id: 9823:GRAMD1C
uniprot id: A0A8D1Q4H3
uniprot id: A0A8D1XGN7
uniprot id: F1SP95
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:SLC9A3R1
gene id: 9823:SLC9A3R1
uniprot id: A0A4X1SHQ2
uniprot id: B8XH67
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
messages: filopodium
messages: microvillus
messages: ruffle

9823:LHFPL4
gene id: 9823:LHFPL4
uniprot id: A0A4X1UXX6
uniprot id: F1SR30
names: Subcellular Location Annotation
messages: Membrane

9823:SLC10A7
gene id: 9823:SLC10A7
uniprot id: A0A4X1SG26
uniprot id: B6EAV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9823:LOC100512154
gene id: 9823:LOC100512154
uniprot id: A0A8D1JLG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CHMP4A
gene id: 9823:CHMP4A
uniprot id: A0A4X1SRC3
names: Similarity
messages: Belongs to the SNF7 family.

9823:LOC100512910
gene id: 9823:LOC100512910
uniprot id: A0A4X1UYS6
uniprot id: I3LED0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ACVR2B
gene id: 9823:ACVR2B
uniprot id: A0A287BJX6
uniprot id: A0A4X1TWT8
uniprot id: Q66T47
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Forms an activin receptor complex with activin type II receptors such as ACVR1B. Interacts with VPS39. Interacts with DYNLT1.
messages: Membrane
messages: Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity (By similarity).
messages: Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity).

9823:OBP
gene id: 9823:OBP
uniprot id: A0A8D0YLM7
uniprot id: Q8WMH1
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9823:APOE
gene id: 9823:APOE
uniprot id: P18650
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: APOE exists as multiple glycosylated and sialylated glycoforms within cells and in plasma. The extent of glycosylation and sialylation are tissue and context specific.
messages: APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Extracellular vesicle
messages: Glycated in plasma VLDL.
messages: Homotetramer. May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs. May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear. May interact with MAPT. May interact with MAP2. In the cerebrospinal fluid, interacts with secreted SORL1. Interacts with PMEL; this allows the loading of PMEL luminal fragment on ILVs to induce fibril nucleation.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Secreted
messages: extracellular matrix
messages: extracellular space
messages: multivesicular body

9823:TRPC6
gene id: 9823:TRPC6
uniprot id: A0A8D1IRE0
names: Subcellular Location Annotation
messages: Membrane

9823:HENMT1
gene id: 9823:HENMT1
uniprot id: A0A480TM63
uniprot id: A0A8D1ENA2
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9823:LOC100622479
gene id: 9823:LOC100622479
uniprot id: A0A5G2QV83
uniprot id: A0A8D1AB39
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:DMAP1
gene id: 9823:DMAP1
uniprot id: A0A287B017
uniprot id: A0A4X1W961
names: Subcellular Location Annotation
messages: Nucleus

9823:MDH1
gene id: 9823:MDH1
uniprot id: A0A480JV95
uniprot id: P11708
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation.
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation.
messages: Cytoplasm
messages: Homodimer.
messages: ISGylated.

9823:INPP5A
gene id: 9823:INPP5A
uniprot id: A0A480L6F1
uniprot id: A0A4X1V3A7
uniprot id: A0A8D1V1M3
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

9823:ETFA
gene id: 9823:ETFA
uniprot id: A0A287A4T2
uniprot id: A0A4X1TY75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9823:LYZ
gene id: 9823:LYZ
uniprot id: P12068
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
messages: Monomer.
messages: Secreted

9823:TDRD3
gene id: 9823:TDRD3
uniprot id: A0A480PRD9
uniprot id: A0A4X1VEY8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

9823:CASP9
gene id: 9823:CASP9
uniprot id: A0A4X1W1Y9
uniprot id: A0A4X1W839
uniprot id: F1SUV9
uniprot id: I3L9A3
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:LOC100514097
gene id: 9823:LOC100514097
uniprot id: A0A8D1BVI8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100620188
gene id: 9823:LOC100620188
uniprot id: A0A8D1S4E3
uniprot id: I3LR01
names: Subcellular Location Annotation
messages: Nucleus

9823:CRABP2
gene id: 9823:CRABP2
uniprot id: C6YXH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9823:NR1H4
gene id: 9823:NR1H4
uniprot id: A0A4X1SVU3
uniprot id: F1SRH0
uniprot id: V5M0Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:APITD1
gene id: 9823:APITD1
uniprot id: A0A8D0WPN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: Nucleus
messages: kinetochore

9823:TAF7L
gene id: 9823:TAF7L
uniprot id: A0A4X1W3R0
uniprot id: A0A5G2QH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9823:USP4
gene id: 9823:USP4
uniprot id: A0A287AEJ8
uniprot id: A0A480JWP0
uniprot id: A0A480T9G5
uniprot id: A0A4X1STE2
uniprot id: A0A4X1SV45
uniprot id: A0A4X1SVE6
uniprot id: A0A8D1M141
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9823:MED19
gene id: 9823:MED19
uniprot id: A0A8D1L1F6
uniprot id: F1SJY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:RHBDF2
gene id: 9823:RHBDF2
uniprot id: A0A8D1WHF2
uniprot id: F1RZ68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

9823:INPPL1
gene id: 9823:INPPL1
uniprot id: D7PF45
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane. Enzymatic activity is enhanced in the presence of phosphatidylserine.
messages: Basal cell membrane
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Expressed abundantly in skeletal muscle tissue.
messages: Interacts with tyrosine phosphorylated form of SHC1 (By similarity). Interacts with EGFR (By similarity). Upon stimulation by the EGF signaling pathway, it forms a complex with SHC1 and EGFR (By similarity). Interacts with cytoskeletal protein SORBS3/vinexin, promoting its localization to the periphery of cells (By similarity). Forms a complex with filamin (FLNA or FLNB), actin, GPIb (GP1BA or GP1BB) that regulates cortical and submembraneous actin (By similarity). Interacts with c-Met/MET, when c-Met/MET is phosphorylated on 'Tyr-1356' (By similarity). Interacts with p130Cas/BCAR1 (By similarity). Interacts with CENTD3/ARAP3 via its SAM domain (By similarity). Interacts with c-Cbl/CBL and CAP/SORBS1 (By similarity). Interacts with activated EPHA2 receptor (By similarity). Interacts with receptor FCGR2A (By similarity). Interacts with receptor FCGR2B (By similarity). Interacts with tyrosine kinase ABL1 (By similarity). Interacts with tyrosine kinase TEC (By similarity). Interacts with CSF1R (By similarity). Interacts (via N-terminus) with SH3YL1 (via SH3 domain). Interacts with FCRL6 (tyrosine phosphorylated form) (By similarity). Interacts (via SH2 domain) with tyrosine phosphorylated KLRC1 (via ITIM) (By similarity). Interacts with NEDD9/HEF1 (By similarity).
messages: Membrane
messages: Nucleus
messages: Nucleus speckle
messages: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:12847108). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (By similarity). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (By similarity). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (By similarity). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (By similarity). Regulates cell adhesion and cell spreading (By similarity). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (By similarity). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (By similarity). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (By similarity). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hema…
messages: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain.
messages: The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or FCGR2A (By similarity). It also mediates the interaction with p130Cas/BCAR1 (By similarity).
messages: Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as insulin, growth factors such as EGF or PDGF, chemokines, integrin ligands and hypertonic and oxidative stress. May be phosphorylated upon IgG receptor FCGR2B-binding. Phosphorylated at Tyr-988 following cell attachment and spreading. Phosphorylated at Tyr-1164 following EGF signaling pathway stimulation.
messages: cytoskeleton
messages: cytosol
messages: filopodium
messages: lamellipodium
messages: spindle pole

9823:SNED1
gene id: 9823:SNED1
uniprot id: A0A8D0V1R5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:GSX2
gene id: 9823:GSX2
uniprot id: A0A4X1UAB5
uniprot id: F1SE61
names: Subcellular Location Annotation
messages: Nucleus

9823:CLDN23
gene id: 9823:CLDN23
uniprot id: A0A8D0N0M7
uniprot id: C3VMW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:CAPNS1
gene id: 9823:CAPNS1
uniprot id: A0A480VEK3
uniprot id: P04574
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: EF-hand domains are paired. EF-hand 1 is paired with EF-hand 2 and EF-hand 3 is paired with EF-hand 4. The fifth EF-hand domain, left unpaired, does not bind the calcium but is responsible of the dimerization by EF-embrace. The first four EF-hand domains bind calcium, however it is not sure if the binding of EF-hand 4 to calcium is physiologically relevant.
messages: Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates.
messages: Membrane
messages: Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity).
messages: The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer.

9823:LOC106509346
gene id: 9823:LOC106509346
uniprot id: A0A5G2QUK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CYP4A24
gene id: 9823:CYP4A24
uniprot id: Q95JF8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9823:NR2E1
gene id: 9823:NR2E1
uniprot id: A0A4X1V8U6
uniprot id: I3LU21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:FCER1G
gene id: 9823:FCER1G
uniprot id: Q9XSZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production b basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (By similarity). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer of CD247 and FCER1G, associates with the ligand binding subunit FCGR3A to form a functional receptor complex (By similarity). Associates with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with common beta chain of interleukin 3 receptor CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (By similarity). Interacts with CD300LH; the interaction may be indirect. Interacts with CD300LD (By similarity). Interacts with TARM1 (By similarity).

9823:C2H19orf70
gene id: 9823:C2H19orf70
uniprot id: A1XQR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, MICOS13/MIC13, APOOL/MIC27 and IMMT/MIC60. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.
messages: Mitochondrion inner membrane

9823:SRM
gene id: 9823:SRM
uniprot id: A0A480SJI2
uniprot id: A0A8D0WJV1
uniprot id: A0A8D1QJC2
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9823:PDIK1L
gene id: 9823:PDIK1L
uniprot id: A0A286ZSE0
uniprot id: A0A4X1VS38
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:MPEG1
gene id: 9823:MPEG1
uniprot id: I3Y4E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9823:MAP3K12
gene id: 9823:MAP3K12
uniprot id: A0A8D0RZV2
uniprot id: A0A8D1Y1T9
uniprot id: F1SFP4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9823:TSPAN2
gene id: 9823:TSPAN2
uniprot id: A0A8D0XAH8
uniprot id: A0A8D1GY01
uniprot id: F1SAW5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:CHMP5
gene id: 9823:CHMP5
uniprot id: A0A4X1UQ22
uniprot id: F1SE87
names: Similarity
messages: Belongs to the SNF7 family.

9823:CFLAR
gene id: 9823:CFLAR
uniprot id: A0A286ZZW1
uniprot id: A0A4X1VD43
uniprot id: Q6QN97
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:MAPK14
gene id: 9823:MAPK14
uniprot id: A0A4X1SVG2
uniprot id: A0A4X1SWQ7
uniprot id: A0A5G2QSG6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9823:MEA1
gene id: 9823:MEA1
uniprot id: A0A1B2TT57
uniprot id: Q95313
names: Caution
names: Function
messages: It is uncertain whether Met-1 or Met-11 is the initiator.
messages: May play an important role in spermatogenesis and/or testis development.

9823:NCOA7
gene id: 9823:NCOA7
uniprot id: A0A5K1U8K2
uniprot id: A0A8D0YHB8
uniprot id: A0A8D1CCK3
uniprot id: F1S2V5
names: Similarity
messages: Belongs to the OXR1 family.

9823:FOXI2
gene id: 9823:FOXI2
uniprot id: A0A4X1V8D8
uniprot id: F1SDK7
names: Subcellular Location Annotation
messages: Nucleus

9823:EIF4A1
gene id: 9823:EIF4A1
uniprot id: A0A4X1V5A1
uniprot id: A6M928
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9823:CASS4
gene id: 9823:CASS4
uniprot id: A0A4X1UQ43
uniprot id: A5GFW5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAS family.
messages: Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity).
messages: Interacts (via SH3 domain) with PTK2/FAK1 (via C-terminus).
messages: Phosphorylated on tyrosines by SRC.
messages: The SH3 domain interacts with the C-terminal region of PTK2/FAK1.
messages: cytoskeleton
messages: focal adhesion

9823:LOC102161030
gene id: 9823:LOC102161030
uniprot id: A0A287B7A8
uniprot id: A0A4X1SXM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9823:RNPC3
gene id: 9823:RNPC3
uniprot id: A0A4X1TI31
uniprot id: A0A4X1TMC8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

9823:KCNV1
gene id: 9823:KCNV1
uniprot id: A0A4X1TC90
uniprot id: F1S1I3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9823:LOC100620442
gene id: 9823:LOC100620442
uniprot id: A0A286ZSZ8
uniprot id: A0A8D1IA24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9823:TNFRSF11B
gene id: 9823:TNFRSF11B
uniprot id: A0A480Z5F1
uniprot id: A0A8D1H0K7
names: Caution
names: Function
names: Subunit
messages: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DMRTA2
gene id: 9823:DMRTA2
uniprot id: A0A4X1WAM5
uniprot id: I3L9S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9823:PPBP
gene id: 9823:PPBP
uniprot id: P43030
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemoattractant factor for neutrophils.
messages: Secreted

9823:CYP21A2
gene id: 9823:CYP21A2
uniprot id: A0A5G2QLE9
uniprot id: A0A8D2C404
uniprot id: P15540
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane.

9823:ERGIC2
gene id: 9823:ERGIC2
uniprot id: A0A4X1V1E8
uniprot id: A0A5G2RKB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9823:LOC100515166
gene id: 9823:LOC100515166
uniprot id: A0A5G2RAS7
uniprot id: A0A8D1XJT1
names: Similarity
messages: Belongs to the intermediate filament family.

9823:FAM46A
gene id: 9823:FAM46A
uniprot id: A0A4X1V4L2
uniprot id: F1RQL4
names: Similarity
messages: Belongs to the TENT family.

9823:TEX13B
gene id: 9823:TEX13B
uniprot id: F1RXI9
names: Similarity
messages: Belongs to the TEX13 family.

9823:DOLPP1
gene id: 9823:DOLPP1
uniprot id: A0A287BKI5
uniprot id: A0A4X1TJ37
uniprot id: A0A4X1TLI0
uniprot id: A0A5G2QW58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9823:HK2
gene id: 9823:HK2
uniprot id: Q1W674
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hexokinase family.
messages: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
messages: Hexokinase activity is specifically inhibited by 2,6-disubstituted glucosamines.
messages: Mitochondrion outer membrane
messages: Monomer (By similarity). Interacts with TIGAR; the interaction increases hexokinase activity in a hypoxia- and HIF1A-dependent manner (By similarity).
messages: The N- and C-terminal halves of the protein contain a hexokinase domain. In contrast to hexokinase-1 and -3 (HK1 and HK3, respectively), both hexokinase domains display catalytic activity. The region connecting the two hexokinase domains is required for the catalytic activity of the N-terminal hexokinase domain. The N-terminal half regulates stability of the whole enzyme.
messages: cytosol

9823:PLPPR1
gene id: 9823:PLPPR1
uniprot id: A0A480RSD9
uniprot id: A0A4X1VFS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

9823:HEATR5B
gene id: 9823:HEATR5B
uniprot id: A0A4X1T2S3
names: Similarity
messages: Belongs to the HEATR5 family.

9823:TRIM26
gene id: 9823:TRIM26
uniprot id: O77666
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction.
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.
messages: Interacts with TBK1; this interaction bridges together TBK1 and NEMO in order to activate TBK1. Interacts with INCA1.
messages: Nucleus

9823:LOC100522011
gene id: 9823:LOC100522011
uniprot id: A0A4X1TCM8
uniprot id: K7GQI7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9823:C14H10orf99
gene id: 9823:C14H10orf99
uniprot id: I3LGZ3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus.
messages: Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (By similarity).
messages: Interacts with SUSD2; the interaction is direct.
messages: Secreted

9823:C14H22orf39
gene id: 9823:C14H22orf39
uniprot id: A0A4X1UTP8
names: Similarity
messages: Belongs to the UPF0545 family.

9823:CDC42EP3
gene id: 9823:CDC42EP3
uniprot id: A0A4X1T096
uniprot id: F1S4Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9823:DEF8
gene id: 9823:DEF8
uniprot id: A0A4X1TF08
names: Similarity
messages: Belongs to the DEF8 family.

9823:GBP2
gene id: 9823:GBP2
uniprot id: B2XWS2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9823:SLC35D1
gene id: 9823:SLC35D1
uniprot id: A0A4X1U6K1
names: Subcellular Location Annotation
messages: Membrane

9823:KIAA1324
gene id: 9823:KIAA1324
uniprot id: A0A8D1Z3V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9823:LOC100154303
gene id: 9823:LOC100154303
uniprot id: A0A4X1UWQ5
uniprot id: F1S8J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LOC100515886
gene id: 9823:LOC100515886
uniprot id: A0A5G2R2J2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PLAGL1
gene id: 9823:PLAGL1
uniprot id: Q2I689
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator. Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Interacts with THRSP.
messages: Nucleus

9823:PRKAR2A
gene id: 9823:PRKAR2A
uniprot id: A0A4X1T0V7
uniprot id: C1PIG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9823:SEZ6L2
gene id: 9823:SEZ6L2
uniprot id: A0A480TLM4
uniprot id: A0A4X1U052
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:LAMB1
gene id: 9823:LAMB1
uniprot id: A0A8D1XZJ0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9823:CCL11
gene id: 9823:CCL11
uniprot id: G8XRI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9823:GCLC
gene id: 9823:GCLC
uniprot id: A0A480K1F4
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9823:ENY2
gene id: 9823:ENY2
uniprot id: A0A286ZK95
uniprot id: A0A4X1TFA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9823:PTP4A2
gene id: 9823:PTP4A2
uniprot id: A0A4X1VZM7
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9823:RNPS1
gene id: 9823:RNPS1
uniprot id: A0A287BFS1
uniprot id: A0A480JVL5
uniprot id: A0A4X1VUG5
uniprot id: A0A4X1VW60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus speckle

9823:PLA1A
gene id: 9823:PLA1A
uniprot id: A0A287BC40
uniprot id: A0A481CXY7
uniprot id: A0A4X1T2R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9823:LOX
gene id: 9823:LOX
uniprot id: A0A4X1U750
uniprot id: F1RLC4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9823:EPHB3
gene id: 9823:EPHB3
uniprot id: A0A8D0S116
uniprot id: A0A8D1CZD4
uniprot id: D3K5K6
uniprot id: F1SG86
names: Subcellular Location Annotation
messages: Membrane

9823:VPS4B
gene id: 9823:VPS4B
uniprot id: A0A287BA12
uniprot id: A0A4X1TUZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Late endosome membrane

9823:NDUFA13
gene id: 9823:NDUFA13
uniprot id: A0A8D1NRT6
uniprot id: F1S6Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

9823:EIF3J
gene id: 9823:EIF3J
uniprot id: A0A4X1VCB2
uniprot id: A0A5G2R3H6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9823:TBX22
gene id: 9823:TBX22
uniprot id: A0A8D1XEK5
uniprot id: F1RPF2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:SLC25A20
gene id: 9823:SLC25A20
uniprot id: A0A4X1SZ37
uniprot id: F1SKK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:C2H5orf30
gene id: 9823:C2H5orf30
uniprot id: A0A4X1TVL4
uniprot id: I3LQ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9823:CHAC2
gene id: 9823:CHAC2
uniprot id: A0A287B4W3
uniprot id: A0A4X1WC75
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9823:GPR183
gene id: 9823:GPR183
uniprot id: F1RP27
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:ELP6
gene id: 9823:ELP6
uniprot id: A0A5G2R8N0
names: Similarity
messages: Belongs to the ELP6 family.

9823:LOC100627836
gene id: 9823:LOC100627836
uniprot id: A0A287BN52
uniprot id: A0A4X1VTZ2
names: Similarity
messages: Belongs to the peptidase C14A family.

9823:PLSCR3
gene id: 9823:PLSCR3
uniprot id: A0A8D1AJD8
uniprot id: I3LHI3
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9823:SPRP
gene id: 9823:SPRP
uniprot id: A0A4X1VVG8
uniprot id: I3LSW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9823:STK38L
gene id: 9823:STK38L
uniprot id: A0A8D0WXD3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:BVES
gene id: 9823:BVES
uniprot id: B8Q0B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the popeye family.
messages: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Important for skeletal muscle and heart development. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (By similarity).
messages: Homodimer. Homodimerization requires the C-terminus cytoplasmic region. Interacts (via the C-terminus cytoplasmic tail) with TJP1. Interacts (via the C-terminus cytoplasmic tail) with ARHGEF25/GEFT (via the DH domain). Interacts (via the C-terminus cytoplasmic tail) with VAMP3 (By similarity). Interacts with KCNK2; the interaction enhances KCNK2 surface expression (By similarity). Interacts with CAV3 (By similarity).
messages: Lateral cell membrane
messages: Membrane
messages: caveola
messages: sarcolemma
messages: tight junction

9823:INPP1
gene id: 9823:INPP1
uniprot id: A0A4X1TID0
uniprot id: F1SN51
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9823:FAM46B
gene id: 9823:FAM46B
uniprot id: A0A4X1UN47
names: Similarity
messages: Belongs to the TENT family.

9823:ADAM22
gene id: 9823:ADAM22
uniprot id: A0A287BFS0
uniprot id: A0A480ZR16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:RPS8
gene id: 9823:RPS8
uniprot id: A0A4X1W9K0
uniprot id: F2Z5F5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9823:MCEE
gene id: 9823:MCEE
uniprot id: A0A4X1UB35
uniprot id: A1XQS7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9823:TPM4
gene id: 9823:TPM4
uniprot id: A0A5S6HGR0
uniprot id: A0A8D0P6L0
uniprot id: D0G7F7
uniprot id: P67937
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
messages: Expression is increased in smooth muscle cells during dedifferentiation from the contractile to the synthetic phenotype.
messages: Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

9823:DPPA2
gene id: 9823:DPPA2
uniprot id: A0A4X1T959
uniprot id: I3LA40
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC494564
gene id: 9823:LOC494564
uniprot id: A0A4X1TI82
uniprot id: Q5IR81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9823:EEF1G
gene id: 9823:EEF1G
uniprot id: A0A8D1XL45
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9823:KCNAB3
gene id: 9823:KCNAB3
uniprot id: A0A287BA57
uniprot id: A0A8D0JV74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

9823:ACSL4
gene id: 9823:ACSL4
uniprot id: A0A287BK93
uniprot id: A0A4X1W4H3
uniprot id: A0A4X1W5F7
uniprot id: Q2QC87
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9823:LOC100516891
gene id: 9823:LOC100516891
uniprot id: K7GSD3
names: Similarity
messages: Belongs to the FAM122 family.

9823:MBL1
gene id: 9823:MBL1
uniprot id: Q5U9S1
names: Caution
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine on bacteria, including strains of A.suis, H.parasuis and A.pleuropneumoniae, and activates the lectin complement pathway. According to some authors, it only binds mannose (PubMed:8602463).
messages: Detected in blood serum (at protein level) (PubMed:16480769, PubMed:16518621). Expressed in liver. Weakly expressed in lung, testis and brain. Not detected in bone marrow and heart.
messages: Hydroxylated on lysine and proline residues within the collagen-like domain.
messages: Incorrectly identified as MBL2 by PubMed:11063327.
messages: Interacts with MASP1 and MASP2 (By similarity). Forms oligomeric complexes of 3, 4, 5 or, predominantly, 6 homotrimers. The homotrimers appear as globular heads that are connected to a central hub by thin stalks.
messages: O-glycosylated. O-linked glycans on hydroxylysine residues consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
messages: Secreted
messages: The helical collagen-like domains from three protein chains assemble into a coiled coil and mediate trimerization.

9823:LOC100511905
gene id: 9823:LOC100511905
uniprot id: A0A4X1UDC9
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9823:SUV39H2
gene id: 9823:SUV39H2
uniprot id: A0A287A6I1
uniprot id: A0A8D0NXY6
uniprot id: A0A8D0WCK3
uniprot id: Q27I49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9823:USP39
gene id: 9823:USP39
uniprot id: A0A4X1W038
uniprot id: A0A5G2RBP5
names: Subcellular Location Annotation
messages: Nucleus

9823:CSNK2A1
gene id: 9823:CSNK2A1
uniprot id: A0A480PD02
uniprot id: A0A4X1SPI6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:LOC106504185
gene id: 9823:LOC106504185
uniprot id: A0A4X1SV90
uniprot id: A0A5G2R0N2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PTGER2
gene id: 9823:PTGER2
uniprot id: A0A4X1WDD2
uniprot id: F1SFF0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:HNRNPH1
gene id: 9823:HNRNPH1
uniprot id: A0A480UJK5
uniprot id: A0A480W1S1
uniprot id: A0A4X1VVA1
uniprot id: A0A4X1VWG0
uniprot id: A0A8D1Y762
uniprot id: A0A8D1YED5
uniprot id: I3L816
names: Subcellular Location Annotation
messages: nucleoplasm

9823:PCYOX1L
gene id: 9823:PCYOX1L
uniprot id: A0A480VKE5
uniprot id: A0A8D1WVR6
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9823:UBL4A
gene id: 9823:UBL4A
uniprot id: A0A480JSN3
uniprot id: A0A4X1T7Z6
names: Subcellular Location Annotation
messages: cytosol

9823:POPDC3
gene id: 9823:POPDC3
uniprot id: B8Q0B5
names: Similarity
messages: Belongs to the popeye family.

9823:SLC2A2
gene id: 9823:SLC2A2
uniprot id: A1YWG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9823:FYTTD1
gene id: 9823:FYTTD1
uniprot id: A0A4X1TLY8
uniprot id: A0A8D1UF20
uniprot id: I3LCE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

9823:TSPAN12
gene id: 9823:TSPAN12
uniprot id: A0A480XES4
uniprot id: A0A4X1W2C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:CEP70
gene id: 9823:CEP70
uniprot id: A0A480T6Y8
uniprot id: A0A4X1TD85
uniprot id: A0A4X1TDC5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

9823:ATP6V1G3
gene id: 9823:ATP6V1G3
uniprot id: A0A287BRQ6
uniprot id: A0A8D1ERN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9823:EEF2K
gene id: 9823:EEF2K
uniprot id: A0A8D1ABQ6
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9823:RIOX1
gene id: 9823:RIOX1
uniprot id: A0A287A2W8
uniprot id: A0A8D1N2Y9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. NO66 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
messages: nucleolus

9823:EGFL6
gene id: 9823:EGFL6
uniprot id: A0A4X1USN2
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:RORA
gene id: 9823:RORA
uniprot id: A0A286ZJH8
uniprot id: A0A4X1TNF7
uniprot id: A0A8D1QKE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:GOLT1A
gene id: 9823:GOLT1A
uniprot id: A0A4X1UXU7
uniprot id: F1S377
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9823:JAK3
gene id: 9823:JAK3
uniprot id: A0A8D1I8T6
uniprot id: K7GSE8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9823:DDR2
gene id: 9823:DDR2
uniprot id: A0A4X1VMV8
names: Subcellular Location Annotation
messages: Membrane

9823:PARP11
gene id: 9823:PARP11
uniprot id: A0A286ZV63
uniprot id: A0A4X1UMS3
uniprot id: A0A4X1UQW7
uniprot id: A0A4X1UQZ1
uniprot id: F1SKY8
uniprot id: I3LAD0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9823:LRRC8D
gene id: 9823:LRRC8D
uniprot id: A0A286ZWM5
uniprot id: A0A4X1U3K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9823:SRSF1
gene id: 9823:SRSF1
uniprot id: Q3YLA6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Asymmetrically dimethylated at arginines, probably by PRMT1, methylation promotes localization to nuclear speckles.
messages: Belongs to the splicing factor SR family.
messages: Consists of two polypeptides of p32 and p33. Identified in the spliceosome C complex. Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as splicing regulator ARVCF. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus). Interacts with SRPK1 and a sliding docking interaction is essential for its sequential and processive phosphorylation by SRPK1. Interacts with NXF1. Interacts with CCNL1, CCNL2 and CDK11B. Interacts with RRP1B. Interacts (when phosphorylated in its RS domain) with TNPO3; promoting nuclear import. Interacts with ILDR1 (via C-terminus) and ILDR2.
messages: Cytoplasm
messages: Nucleus speckle
messages: Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Phosphorylated by SRPK1 at multiple serines in its RS domain via a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds to a docking groove in the large lobe of the kinase domain of SRPK1 and this induces certain structural changes in SRPK1 and/or RRM 2 domain of SRSF1, allowing RRM 2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM 2, which then docks at the docking groove of SRPK1. This also signals RRM 2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed (By similarity).
messages: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway (By similarity).
messages: The RRM 2 domain plays an important role in governing both the binding mode and the phosphorylation mechanism of the RS domain by SRPK1. RS domain and RRM 2 are uniquely positioned to initiate a highly directional (C-terminus to N-terminus) phosphorylation reaction in which the RS domain slides through an extended electronegative channel separating the docking groove of SRPK1 and the active site. RRM 2 binds toward the periphery of the active site and guides the directional phosphorylation mechanism. Both the RS domain and an RRM domain are required for nucleocytoplasmic shuttling (By similarity).

9823:LOC100621954
gene id: 9823:LOC100621954
uniprot id: A0A5G2R433
uniprot id: A0A8D0RN57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLC25A22
gene id: 9823:SLC25A22
uniprot id: A0A4X1VXK5
uniprot id: F1RYY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9823:SELENOM
gene id: 9823:SELENOM
uniprot id: C4PK53
names: Similarity
messages: Belongs to the selenoprotein M/F family.

9823:PDIA3
gene id: 9823:PDIA3
uniprot id: A0A8D0IPP9
uniprot id: E1CAJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9823:CHRM2
gene id: 9823:CHRM2
uniprot id: P06199
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
messages: Cell membrane
messages: Interacts with ARRB1 and ARRB2 (By similarity). Interacts with RACK1; the interaction regulates CHRM2 internalization.
messages: Phosphorylated in response to agonist treatment.
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

9823:ATP1B1
gene id: 9823:ATP1B1
uniprot id: P05027
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Glutathionylated (By similarity). N-glycosylated (By similarity).
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic subunit ATP12A (By similarity). Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (By similarity). Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (By similarity). Interacts with TRAF3 and TRAF6 (By similarity).
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1.
messages: sarcolemma

9823:IFN-ALPHA-5
gene id: 9823:IFN-ALPHA-5
uniprot id: C8CK96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:PADI3
gene id: 9823:PADI3
uniprot id: A0A4X1W7D6
uniprot id: F1SUR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9823:NOL11
gene id: 9823:NOL11
uniprot id: A0A480K148
uniprot id: A0A4X1SX68
names: Subcellular Location Annotation
messages: nucleolus

9823:GATA2
gene id: 9823:GATA2
uniprot id: A0A8D1WX80
uniprot id: Q865U9
names: Subcellular Location Annotation
messages: Nucleus

9823:TLR9
gene id: 9823:TLR9
uniprot id: Q865R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
messages: Lysosome
messages: Membrane
messages: phagosome

9823:HTR4
gene id: 9823:HTR4
uniprot id: Q6Q253
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

9823:ATP13A2
gene id: 9823:ATP13A2
uniprot id: A0A8D1L3V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9823:DOLK
gene id: 9823:DOLK
uniprot id: A0A4X1TP87
names: Similarity
messages: Belongs to the polyprenol kinase family.

9823:HTR1D
gene id: 9823:HTR1D
uniprot id: A0A4X1VZL4
uniprot id: I3L844
uniprot id: Q9N263
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9823:DPM2
gene id: 9823:DPM2
uniprot id: A0A287B2D7
uniprot id: A0A4X1U6E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9823:SIM1
gene id: 9823:SIM1
uniprot id: A0A4X1VGH0
uniprot id: D3KAY4
names: Subcellular Location Annotation
messages: Nucleus

9823:CWF19L1
gene id: 9823:CWF19L1
uniprot id: A0A4X1U4C8
uniprot id: F1S8V2
names: Similarity
messages: Belongs to the CWF19 family.

9823:CACNG6
gene id: 9823:CACNG6
uniprot id: A0A8D1T738
uniprot id: F1RNI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

9823:CXCL11
gene id: 9823:CXCL11
uniprot id: A0A4X1SX03
uniprot id: B3GDY9
uniprot id: F1RYT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9823:TPPP
gene id: 9823:TPPP
uniprot id: A0A4X1TI72
uniprot id: B1Q0K1
names: Similarity
messages: Belongs to the TPPP family.

9823:LOC106508078
gene id: 9823:LOC106508078
uniprot id: A0A4X1UI59
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MED4
gene id: 9823:MED4
uniprot id: A0A286ZZ81
uniprot id: A0A8D2BUW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:SUMO2
gene id: 9823:SUMO2
uniprot id: C7S2Z6
uniprot id: P61958
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
messages: Interacts with SAE2 and UBE2I. Interacts with ZNF451. Identified in a complex with ZNF451 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains). Interacts with MTA1 (By similarity). Interacts with HINT1 (By similarity). Interacts with GCNA (via SIM domains); this interaction allows the GCNA recruitment to DPCs sites (By similarity).
messages: Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
messages: Nucleus
messages: PML body
messages: Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 (By similarity).
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity).

9823:LOC100520389
gene id: 9823:LOC100520389
uniprot id: A0A8D1BP59
names: Subcellular Location Annotation
messages: Nucleus

9823:PPP1R15B
gene id: 9823:PPP1R15B
uniprot id: A0A4X1UZ41
uniprot id: I3LIA2
names: Similarity
messages: Belongs to the PPP1R15 family.

9823:MS4A4A
gene id: 9823:MS4A4A
uniprot id: A0A4X1VML0
names: Similarity
messages: Belongs to the MS4A family.

9823:ACTC1
gene id: 9823:ACTC1
uniprot id: A0A4X1UL06
uniprot id: B6VNT8
names: Similarity
messages: Belongs to the actin family.

9823:PRTFDC1
gene id: 9823:PRTFDC1
uniprot id: A0A8D0XQ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9823:VPS18
gene id: 9823:VPS18
uniprot id: A0A8D1AUZ5
uniprot id: F1SSU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9823:ASF1A
gene id: 9823:ASF1A
uniprot id: A0A4X1TG55
uniprot id: F1SF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9823:ARHGEF18
gene id: 9823:ARHGEF18
uniprot id: A0A286ZWT3
names: Subcellular Location Annotation
messages: Cytoplasm

9823:CAB39L
gene id: 9823:CAB39L
uniprot id: A0A4X1SLB8
uniprot id: F1RK18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9823:CPT1A
gene id: 9823:CPT1A
uniprot id: A0A8D1A2C9
uniprot id: Q95JG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:NUP188
gene id: 9823:NUP188
uniprot id: A0A480WX19
uniprot id: A0A4X1TP64
names: Subcellular Location Annotation
messages: nuclear pore complex

9823:CD40
gene id: 9823:CD40
uniprot id: Q8SQ34
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).
messages: Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).

9823:EVL
gene id: 9823:EVL
uniprot id: A0A480KZG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: lamellipodium
messages: stress fiber

9823:GNAS
gene id: 9823:GNAS
uniprot id: A0A480UPA5
uniprot id: A0A4X1UVC6
uniprot id: A0A4X1UWE8
uniprot id: A0A8D0WIW3
uniprot id: A5GFU5
uniprot id: A5GFU6
uniprot id: A5GFU7
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9823:SFTPD
gene id: 9823:SFTPD
uniprot id: A0A287BPZ1
uniprot id: A0A4X1SIT2
uniprot id: Q9N1X4
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPD family.
messages: Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties (By similarity).
messages: Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
messages: Oligomeric complex of 4 set of homotrimers.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
messages: extracellular matrix
messages: surface film

9823:TRIM2
gene id: 9823:TRIM2
uniprot id: A0A8D1G8G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9823:EML3
gene id: 9823:EML3
uniprot id: A0A4X1VGG4
uniprot id: A0A8D1EG87
uniprot id: F1RPX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9823:ACADSB
gene id: 9823:ACADSB
uniprot id: A0A4X1SFV4
uniprot id: F1SED0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9823:HDAC1
gene id: 9823:HDAC1
uniprot id: A0A4X1VYK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

9823:TVP23B
gene id: 9823:TVP23B
uniprot id: A0A287BIS8
uniprot id: A0A5K1VLD8
uniprot id: A0A8D1EAE9
uniprot id: A0A8D1U9C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9823:CAMKK2
gene id: 9823:CAMKK2
uniprot id: A0A480WNA1
uniprot id: A0A8D0M9W4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:GLI1
gene id: 9823:GLI1
uniprot id: A0A8D0JJA6
uniprot id: H6WJF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9823:NUP133
gene id: 9823:NUP133
uniprot id: A0A481BDT0
uniprot id: A0A4X1U7F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

9823:KCNN1
gene id: 9823:KCNN1
uniprot id: A0A287BKI2
uniprot id: A0A8D0S5X8
names: Subcellular Location Annotation
messages: Membrane

9823:HTT
gene id: 9823:HTT
uniprot id: Q9GM99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

9823:RIPPLY2
gene id: 9823:RIPPLY2
uniprot id: A0A4X1V6G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9823:RHO
gene id: 9823:RHO
uniprot id: O18766
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.
messages: Homodimer (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts with GRK1 (By similarity). Interacts (phosphorylated form) with SAG. Interacts with GNAT1. Interacts with GNAT3. SAG and G-proteins compete for a common binding site (By similarity). Interacts with PRCD; the interaction promotes PRCD stability.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (PubMed:9335046). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
messages: photoreceptor outer segment

9823:NOC3L
gene id: 9823:NOC3L
uniprot id: A0A4X1USA5
uniprot id: B8Y7D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

9823:GKN1
gene id: 9823:GKN1
uniprot id: Q8HYA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the gastrokine family.
messages: Cytoplasmic granule
messages: Golgi apparatus
messages: Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
messages: Highly expressed specifically in surface cells of the antrum mucosa from where it is secreted.
messages: Secreted

9823:MAN1A2
gene id: 9823:MAN1A2
uniprot id: A0A480JM90
uniprot id: A0A4X1SUB0
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9823:CPNE5
gene id: 9823:CPNE5
uniprot id: A0A287A2T7
uniprot id: A0A287AMN8
uniprot id: A0A4X1SSP6
uniprot id: A0A4X1SSR5
names: Similarity
messages: Belongs to the copine family.

9823:HRH2
gene id: 9823:HRH2
uniprot id: A0A4X1SL18
uniprot id: A0A5G2RG47
uniprot id: A0A8D1GHH8
uniprot id: I3L760
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:COQ10B
gene id: 9823:COQ10B
uniprot id: A0A8D1P741
uniprot id: F1SMZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9823:FAM172A
gene id: 9823:FAM172A
uniprot id: A0A8D1GPV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: Nucleus

9823:LOC100524011
gene id: 9823:LOC100524011
uniprot id: A0A5G2QUE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MTMR4
gene id: 9823:MTMR4
uniprot id: A0A4X1SM89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9823:GRK1
gene id: 9823:GRK1
uniprot id: A0A4X1U1R4
uniprot id: F1RN35
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9823:NDUFB2
gene id: 9823:NDUFB2
uniprot id: A0A287BQ62
uniprot id: A0A4X1V766
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9823:SLC34A1
gene id: 9823:SLC34A1
uniprot id: Q3LUR7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9823:LOC100522678
gene id: 9823:LOC100522678
uniprot id: A0A480EHC1
uniprot id: A0A4X1TWD8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9823:SBF1
gene id: 9823:SBF1
uniprot id: A0A287AUI1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9823:TXNIP
gene id: 9823:TXNIP
uniprot id: A0A480K2Q0
uniprot id: Q2HY40
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arrestin family.
messages: Cytoplasm
messages: Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (By similarity). Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4 (By similarity).
messages: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity).
messages: Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.

9823:PRDM1
gene id: 9823:PRDM1
uniprot id: A0A287BLU1
uniprot id: A0A4X1VA80
uniprot id: A0A4X1VE21
uniprot id: A0A4X1VE26
uniprot id: F1RYP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9823:LSM2
gene id: 9823:LSM2
uniprot id: A0A4X1V9D9
uniprot id: A5A8V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9823:GCLM
gene id: 9823:GCLM
uniprot id: A0A4X1U0N2
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

9823:WDYHV1
gene id: 9823:WDYHV1
uniprot id: A0A8D0XEU2
uniprot id: F1RR17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9823:ARGLU1
gene id: 9823:ARGLU1
uniprot id: A0A4X1U8P3
uniprot id: F2Z517
names: Similarity
messages: Belongs to the UPF0430 family.

9823:FOXM1
gene id: 9823:FOXM1
uniprot id: A0A287AG20
uniprot id: A0A4X1ULX6
uniprot id: A0A4X1UN77
uniprot id: A0A8D0QLN1
uniprot id: I3LTP4
names: Subcellular Location Annotation
messages: Nucleus

9823:ARF2
gene id: 9823:ARF2
uniprot id: B9V4E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9823:GADD45A
gene id: 9823:GADD45A
uniprot id: Q15B93
names: Similarity
messages: Belongs to the GADD45 family.

9823:SF3B6
gene id: 9823:SF3B6
uniprot id: A0A4X1TZT5
uniprot id: F2Z5F1
names: Subcellular Location Annotation
messages: Nucleus

9823:EOMES
gene id: 9823:EOMES
uniprot id: A0A8D1AAM8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:EIF1
gene id: 9823:EIF1
uniprot id: A0A4X1U8Q2
uniprot id: F2Z553
names: Similarity
messages: Belongs to the SUI1 family.

9823:NDUFA10
gene id: 9823:NDUFA10
uniprot id: F1SIS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

9823:SERPINB10
gene id: 9823:SERPINB10
uniprot id: A0A4X1TSR5
uniprot id: F1SMW8
names: Similarity
messages: Belongs to the serpin family.

9823:DUSP1
gene id: 9823:DUSP1
uniprot id: A0A8D0WSA6
uniprot id: F1RS00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9823:ROCK1
gene id: 9823:ROCK1
uniprot id: A0A4X1VPV6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

9823:LYVE1
gene id: 9823:LYVE1
uniprot id: A0A8D1ZLE8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:PTPN1
gene id: 9823:PTPN1
uniprot id: A5GHK9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9823:LTC4S
gene id: 9823:LTC4S
uniprot id: A0A4X1VVE8
uniprot id: I3LEI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:FOXN3
gene id: 9823:FOXN3
uniprot id: Q33BP8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (By similarity).
messages: Interacts through its C-terminus with the C-terminus of SNW1/SKIP.
messages: Nucleus

9823:HOXA5
gene id: 9823:HOXA5
uniprot id: E1U314
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:TRIP10
gene id: 9823:TRIP10
uniprot id: A0A4X1VQC1
uniprot id: A0A8D1TP62
uniprot id: F1SCM9
uniprot id: I3LAS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Lysosome
messages: Membrane
messages: cell cortex

9823:KRTCAP2
gene id: 9823:KRTCAP2
uniprot id: A0A8D1HYE7
uniprot id: F1RGR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9823:NKIRAS1
gene id: 9823:NKIRAS1
uniprot id: A0A4X1UMA3
uniprot id: I3L911
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9823:LOC100627422
gene id: 9823:LOC100627422
uniprot id: A0A480JHP1
uniprot id: A0A8D0TMC9
names: Subcellular Location Annotation
messages: Nucleus

9823:PKD2
gene id: 9823:PKD2
uniprot id: A0A4X1U842
uniprot id: F2VYA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane

9823:ACTL7A
gene id: 9823:ACTL7A
uniprot id: A0A8D0ZMQ0
uniprot id: F1SP29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

9823:SLC7A1
gene id: 9823:SLC7A1
uniprot id: A0A8D1WAE7
uniprot id: Q5DT24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9823:ZSCAN31
gene id: 9823:ZSCAN31
uniprot id: A0A4X1VF73
uniprot id: I3LQQ7
names: Subcellular Location Annotation
messages: Nucleus

9823:CBL
gene id: 9823:CBL
uniprot id: A0A286ZQE1
uniprot id: A0A8D1S6Y7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9823:TRMT10C
gene id: 9823:TRMT10C
uniprot id: A0A4X1UZ56
uniprot id: F1SL15
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9823:RRAGA
gene id: 9823:RRAGA
uniprot id: A0A4X1WBE4
uniprot id: F2Z5Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9823:PPP1CA
gene id: 9823:PPP1CA
uniprot id: A0A4X1T6I4
uniprot id: Q2EHH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9823:GLP1R
gene id: 9823:GLP1R
uniprot id: A0A4X1SP80
uniprot id: F1RVR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9823:SYPL2
gene id: 9823:SYPL2
uniprot id: A0A8D0WHT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9823:YPEL4
gene id: 9823:YPEL4
uniprot id: A0A480PG35
uniprot id: A0A4X1VPK4
names: Similarity
messages: Belongs to the yippee family.

9823:IGF1R
gene id: 9823:IGF1R
uniprot id: A0A4X1UKG1
uniprot id: F1CK17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9823:PTGFR
gene id: 9823:PTGFR
uniprot id: A0A4X1UTM0
uniprot id: Q95L06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:RMI1
gene id: 9823:RMI1
uniprot id: A0A8D1XHI9
uniprot id: F1S4G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9823:TMEM47
gene id: 9823:TMEM47
uniprot id: A0A4X1VH18
uniprot id: F2Z5B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9823:PIH1D1
gene id: 9823:PIH1D1
uniprot id: A0A4X1VZR4
uniprot id: F1RHZ8
names: Similarity
messages: Belongs to the PIH1 family.

9823:SLC24A4
gene id: 9823:SLC24A4
uniprot id: A0A8D2BLJ6
uniprot id: F1SD72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9823:MED25
gene id: 9823:MED25
uniprot id: A0A480SBS6
uniprot id: A0A8D1Q9G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 25 family.
messages: Nucleus

9823:TSNAX
gene id: 9823:TSNAX
uniprot id: A0A287B8Q8
uniprot id: A0A4X1U8N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9823:SLCO4C1
gene id: 9823:SLCO4C1
uniprot id: A0A8D1C7W9
uniprot id: F1RN62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9823:IFNAR1
gene id: 9823:IFNAR1
uniprot id: Q764M8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Heterodimer with IFNAR2; forming the receptor for type I interferon. Interacts with TYK2. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-482. Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Interacts with SHMT2; this promotes interaction with ABRAXAS2 and the BRISC complex. Interacts with TRIM10; this interaction prevents association between IFNAR1 and TYK2.
messages: Late endosome
messages: Lysosome
messages: Palmitoylation at Cys-464 is required for the activation of STAT1 and STAT2.
messages: Phosphorylated on tyrosine residues in response to interferon-binding: phosphorylation by TYK2 tyrosine kinase creates docking sites for STAT proteins. Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination.
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
messages: Ubiquitinated, leading to its internalization and degradation. Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex.

9823:PPP2CA
gene id: 9823:PPP2CA
uniprot id: A0A1B2TT50
uniprot id: P67776
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family.
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with NXN; the interaction is direct (By similarity). Interacts with KCTD20 (By similarity). Interacts with BTBD10 (By similarity). Interacts with SGO1 and SGO2. Interacts with TP53. Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3. Interacts with RAF1. Interaction with IGBP1 protects unassembled PPP2CA from degradative ubiquitination. Interacts with GSK3B (via C2 domain). Interacts with MFHAS1; retains PPP2CA into the cytoplasm and excludes it from the nucleus. Interacts with PABIR1/FAM122A. Interacts with ADCY8; interaction is phosphatase activity-dependent; antagonizes interaction between ADCY8 and calmodulin. Interacts with CRTC3 (when phosphorylated at 'Ser-391'). Interacts with SPRY2; the interaction is inhibited by TESK1 interaction with SPRY2, possibly by vesicular sequestration of SPRY2. Interacts with TRAF3IP3. Interacts with AMBRA1 (via PxP motifs); enhancing interaction between PPP2CA and MYC or FOXO3 (By similarity). Forms a complex with AMBRA1 and BECN1; AMBRA1 and BECN1 components of the complex regulate MYC stability via different pathways (By similarity).
messages: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (By similarity). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (By similarity). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (By similarity).
messages: Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation (By similarity).
messages: Polyubiquitinated, leading to its degradation by the proteasome.
messages: Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity).
messages: centromere
messages: spindle pole

9823:CACUL1
gene id: 9823:CACUL1
uniprot id: A0A4X1SY46
uniprot id: A0A5G2QXL2
names: Similarity
messages: Belongs to the cullin family.

9823:HSPA5
gene id: 9823:HSPA5
uniprot id: A0A480UES1
uniprot id: A0A4X1UFV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen

9823:STAT4
gene id: 9823:STAT4
uniprot id: A0A8D1H9E6
uniprot id: E1U8C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9823:MBP
gene id: 9823:MBP
uniprot id: Q6J2R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

9823:CBR1
gene id: 9823:CBR1
uniprot id: I3RWJ1
uniprot id: Q28960
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Expressed in kidney (at protein level).
messages: Highly expressed in testis from newborns. After 30 days the levels are markedly decreased.
messages: Monomer.
messages: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha (PubMed:1377683, PubMed:1597188). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity).

9823:RPS19
gene id: 9823:RPS19
uniprot id: A0A8D0JAI4
uniprot id: A0A8D1XF00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

9823:EPHA3
gene id: 9823:EPHA3
uniprot id: A0A4X1UPW4
uniprot id: D3K5K5
names: Subcellular Location Annotation
messages: Membrane

9823:GDI1
gene id: 9823:GDI1
uniprot id: A0A4X1T6D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9823:CD6
gene id: 9823:CD6
uniprot id: A0A8D0RYW7
uniprot id: A0A8D1WL46
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:FLVCR1
gene id: 9823:FLVCR1
uniprot id: B7U652
names: Subcellular Location Annotation
messages: Membrane

9823:ZFP36L1
gene id: 9823:ZFP36L1
uniprot id: A0A286ZLK6
uniprot id: A0A4X1U1G3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9823:S100A8
gene id: 9823:S100A8
uniprot id: A0A4X1VVF8
uniprot id: C3S7K5
names: Similarity
messages: Belongs to the S-100 family.

9823:LOC100152911
gene id: 9823:LOC100152911
uniprot id: A0A4X1SIT3
uniprot id: F1SP69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:POLR2G
gene id: 9823:POLR2G
uniprot id: A0A4X1VKG7
uniprot id: I3LJZ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

9823:CSN2
gene id: 9823:CSN2
uniprot id: B5KLC4
uniprot id: P39037
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-casein family.
messages: Important role in determination of the surface properties of the casein micelles.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9823:GOT2
gene id: 9823:GOT2
uniprot id: A0A480XZ96
uniprot id: P00506
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
messages: Cell membrane
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
messages: Mitochondrion matrix

9823:HPGD
gene id: 9823:HPGD
uniprot id: A0A4X1V850
uniprot id: D0G6X9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:TOMM40
gene id: 9823:TOMM40
uniprot id: A0A8D1K2F8
uniprot id: D0V557
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9823:GLS2
gene id: 9823:GLS2
uniprot id: A0A8D0P4A7
uniprot id: A0A8D1Q6Y5
uniprot id: F1SLB4
names: Similarity
messages: Belongs to the glutaminase family.

9823:FAU
gene id: 9823:FAU
uniprot id: P55812
names: Miscellaneous
names: Similarity
messages: Belongs to the ubiquitin family.
messages: This protein is synthesized with ribosomal S30 as its C-terminal extension.

9823:KIFC1
gene id: 9823:KIFC1
uniprot id: A0A4X1TA32
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:PSMA5
gene id: 9823:PSMA5
uniprot id: A0A4X1TE96
uniprot id: F2Z5K2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9823:C5
gene id: 9823:C5
uniprot id: Q6VPV1
names: Subcellular Location Annotation
messages: Secreted

9823:ADD3
gene id: 9823:ADD3
uniprot id: A0A287AQ41
uniprot id: A0A287BSU1
uniprot id: A0A4X1TEQ8
uniprot id: A0A4X1TIC1
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9823:NDUFAF4
gene id: 9823:NDUFAF4
uniprot id: A0A4X1VJT3
uniprot id: F1RY01
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9823:SPIN2B
gene id: 9823:SPIN2B
uniprot id: A0A286ZXD6
uniprot id: A0A4X1VL59
uniprot id: A0A8D1B164
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

9823:NPC2
gene id: 9823:NPC2
uniprot id: O97763
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NPC2 family.
messages: Binds cholesterol in a hydrophobic pocket; there are no hydrogen bonds between the sterol and the protein.
messages: Endoplasmic reticulum
messages: Found in the fluid from the distal caput to cauda epididymis, not detected in the rete testis and the proximal and middle caput epididymal fluids (at protein level).
messages: Interacts with NPC1 (via the second lumenal domain) in a cholestrol-dependent manner. Interacts with NUS1/NgBR, the interaction stabilizes NCP2 and regulates cholesterol trafficking. Interacts with DHDDS. Interacts with NEDD4L (via C2 domain). Interacts with NPC1L1.
messages: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes (By similarity). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:10366780). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
messages: Lysosome
messages: N-glycosylated. Found in the epididymal fluid as a 19 kDa glycoprotein that is processed during its passage through the epididymis into a 16 kDa protein.
messages: Secreted

9823:AREG
gene id: 9823:AREG
uniprot id: A0A4X1T4E6
uniprot id: Q9BDH4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:OPN4
gene id: 9823:OPN4
uniprot id: A0A8D1E3Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9823:ACAA1
gene id: 9823:ACAA1
uniprot id: A0A480UJ69
uniprot id: A0A8D0K0L4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9823:PIWIL2
gene id: 9823:PIWIL2
uniprot id: D9YJ49
uniprot id: I3LE69
names: Similarity
messages: Belongs to the argonaute family.

9823:ANXA10
gene id: 9823:ANXA10
uniprot id: A0A8D1CYU2
uniprot id: I3LFK6
names: Similarity
messages: Belongs to the annexin family.

9823:TAS2R41
gene id: 9823:TAS2R41
uniprot id: A0A8D1ZWS9
uniprot id: F1SSI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9823:NR1H3
gene id: 9823:NR1H3
uniprot id: A0A287B056
uniprot id: A0A480WYK6
uniprot id: A0A4X1VT52
uniprot id: Q4TU03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9823:MED11
gene id: 9823:MED11
uniprot id: A0A4X1UXV1
uniprot id: F1RFT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9823:GLUD1
gene id: 9823:GLUD1
uniprot id: A0A4X1VHE8
uniprot id: F1SEN2
uniprot id: P42174
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity. Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Endoplasmic reticulum
messages: Homohexamer (By similarity). Interacts with HADH; this interaction inhibits the activation of GLUD1 (By similarity).
messages: Liver, brain and thyroid.
messages: Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:8240242). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
messages: Mitochondrion
messages: Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme. Inhibited by SIRT4 (By similarity). Inhibited by HADH (By similarity).

9823:HSPA1L
gene id: 9823:HSPA1L
uniprot id: A5A8V7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Interacts with PRKN.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.

9823:POLE2
gene id: 9823:POLE2
uniprot id: A0A4X1SII8
uniprot id: F1SHZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

9823:ACTR2
gene id: 9823:ACTR2
uniprot id: A0A4X1WA58
uniprot id: A0A5G2RE71
uniprot id: A0A8D1KVK4
uniprot id: B5APU3
names: Similarity
messages: Belongs to the actin family.

9823:SLC39A5
gene id: 9823:SLC39A5
uniprot id: A0A480S7M3
uniprot id: A0A4X1W3N1
names: Subcellular Location Annotation
messages: Membrane

9823:RRP15
gene id: 9823:RRP15
uniprot id: A0A287AR18
uniprot id: A0A4X1TN88
names: Similarity
messages: Belongs to the RRP15 family.

9823:POLA2
gene id: 9823:POLA2
uniprot id: A0A8D1HH88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

9823:NMI
gene id: 9823:NMI
uniprot id: A0A8D1G870
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9823:LPCAT4
gene id: 9823:LPCAT4
uniprot id: A0A5G2R2A1
uniprot id: A0A8D1CSV5
uniprot id: C0KEG5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:MNAT1
gene id: 9823:MNAT1
uniprot id: A0A4X1WCT0
uniprot id: C9K507
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9823:HSD17B1
gene id: 9823:HSD17B1
uniprot id: A0A4X1TVP1
uniprot id: B2X0A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Favors the reduction of estrogens and androgens. Uses preferentially NADH.

9823:ATP13A5
gene id: 9823:ATP13A5
uniprot id: A0A4X1UAS6
uniprot id: I3LUR3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:SLC39A13
gene id: 9823:SLC39A13
uniprot id: A0A480PWP8
uniprot id: A0A4X1VQF4
names: Subcellular Location Annotation
messages: Membrane

9823:TATDN1
gene id: 9823:TATDN1
uniprot id: A0A287A0F5
uniprot id: A0A4X1T073
uniprot id: A0A8D0ZR77
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9823:CRYZ
gene id: 9823:CRYZ
uniprot id: A0A8D1BUV9
uniprot id: Q19QT8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9823:NAA10
gene id: 9823:NAA10
uniprot id: A0A8D1A442
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9823:ATP5L
gene id: 9823:ATP5L
uniprot id: A0A4X1SQX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9823:COASY
gene id: 9823:COASY
uniprot id: Q8MIR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
messages: Cytoplasm
messages: In the central section; belongs to the eukaryotic CoaD family.
messages: Mitochondrion matrix
messages: Monomer.
messages: The N-terminus is blocked.

9823:GCNT1
gene id: 9823:GCNT1
uniprot id: A0A4X1W1G4
uniprot id: F1SIN0
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9823:DCP1B
gene id: 9823:DCP1B
uniprot id: A0A4X1UEQ7
uniprot id: A0A8D1Y1T4
names: Similarity
messages: Belongs to the DCP1 family.

9823:ACTL9
gene id: 9823:ACTL9
uniprot id: A0A4X1VLN3
uniprot id: F1SA46
names: Similarity
messages: Belongs to the actin family.

9823:SPECC1L
gene id: 9823:SPECC1L
uniprot id: A0A287A9V0
uniprot id: A0A4X1V4F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9823:CHEK1
gene id: 9823:CHEK1
uniprot id: A0A4X1VFW9
uniprot id: F1S774
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9823:ASIC3
gene id: 9823:ASIC3
uniprot id: A0A8D1YS29
names: Subcellular Location Annotation
messages: Membrane

9823:S1PR2
gene id: 9823:S1PR2
uniprot id: A0A4X1V5P1
uniprot id: F1S3I6
names: Subcellular Location Annotation
messages: Membrane

9823:IFN-OMEGA-2
gene id: 9823:IFN-OMEGA-2
uniprot id: C8CKC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:RIC8A
gene id: 9823:RIC8A
uniprot id: A0A4X1VZI9
uniprot id: F1RGD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9823:LOC100524873
gene id: 9823:LOC100524873
uniprot id: A0A480S4Z8
uniprot id: A0A4X1W4V4
uniprot id: A0A4X1WAF4
uniprot id: F1S3W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9823:SULT4A1
gene id: 9823:SULT4A1
uniprot id: A0A4X1W4F6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:TCP1
gene id: 9823:TCP1
uniprot id: A0A8D1SZI5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9823:KCNK3
gene id: 9823:KCNK3
uniprot id: A0A8D2C2P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:UBIAD1
gene id: 9823:UBIAD1
uniprot id: A0A287B839
uniprot id: A0A8D1U5K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9823:WT1
gene id: 9823:WT1
uniprot id: A0A4X1SVX2
uniprot id: O62651
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. Starting from the N-terminus, the second zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-carboxylcytosine.
messages: Cytoplasm
messages: Expressed during kidney development.
messages: Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP, AMER1 and SRY. Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with U2AF2. Interacts with HNRNPU via the zinc-finger region. Interacts with CITED2. Interacts with RBM4 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Partially edited.
messages: Presence of the KTS motif hinders interactions between DNA and zinc-finger 4.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
messages: nucleolus
messages: nucleoplasm

9823:UBE2E2
gene id: 9823:UBE2E2
uniprot id: Q06AB0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9823:STAT5A
gene id: 9823:STAT5A
uniprot id: Q9TUZ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcription factor STAT family.
messages: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity).
messages: Cytoplasm
messages: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7. Interacts with ERBB4 (By similarity). Interacts with EBF4.
messages: ISGylated.
messages: Nucleus
messages: Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (By similarity). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-699 (By similarity).

9823:AMIGO1
gene id: 9823:AMIGO1
uniprot id: A0A286ZN55
uniprot id: A0A8D0LLU8
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9823:PDK4
gene id: 9823:PDK4
uniprot id: A0A4X1TQ11
uniprot id: C1IHT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9823:HSPB7
gene id: 9823:HSPB7
uniprot id: A0A287A0M1
uniprot id: A0A4X1W7Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9823:SETD6
gene id: 9823:SETD6
uniprot id: A0A4X1UXW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

9823:ANAPC16
gene id: 9823:ANAPC16
uniprot id: A0A480E6G8
uniprot id: A0A4X1T7C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9823:BOLA3
gene id: 9823:BOLA3
uniprot id: A0A4X1W6F2
names: Similarity
messages: Belongs to the BolA/IbaG family.

9823:ARL2BP
gene id: 9823:ARL2BP
uniprot id: A0A4X1SDE4
uniprot id: A0A5G2QXD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9823:ICAM2
gene id: 9823:ICAM2
uniprot id: A0A4X1SYT5
uniprot id: Q6VY03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9823:ALG6
gene id: 9823:ALG6
uniprot id: A0A8D1M5U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:FEZ2
gene id: 9823:FEZ2
uniprot id: A0A8D1WLV8
uniprot id: A0A8D2BSS3
names: Similarity
messages: Belongs to the zygin family.

9823:FAM76B
gene id: 9823:FAM76B
uniprot id: A0A4X1TWG2
uniprot id: F1STI7
names: Similarity
messages: Belongs to the FAM76 family.

9823:KCNK5
gene id: 9823:KCNK5
uniprot id: A0A8D1T572
uniprot id: F1RVQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9823:ITIH2
gene id: 9823:ITIH2
uniprot id: O02668
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITIH family.
messages: Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
messages: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin.
messages: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Secreted

9823:TMEM18
gene id: 9823:TMEM18
uniprot id: A0A4X1UM98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Membrane
messages: Nucleus membrane

9823:LRRFIP1
gene id: 9823:LRRFIP1
uniprot id: A0A286ZZI6
uniprot id: A0A480IUI5
uniprot id: A0A8D1H6P3
names: Similarity
messages: Belongs to the LRRFIP family.

9823:EXTL2
gene id: 9823:EXTL2
uniprot id: A0A287BCT9
uniprot id: A0A4X1TSB0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:ALCAM
gene id: 9823:ALCAM
uniprot id: A0A4X1SHK9
uniprot id: A0A5K1UB62
uniprot id: A0A8D1UMV5
uniprot id: K7GLE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9823:AGRP
gene id: 9823:AGRP
uniprot id: Q9TU18
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Golgi apparatus lumen
messages: Interacts with melanocortin receptors MC3R, MC4R and MC5R.
messages: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
messages: Secreted
messages: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

9823:FAM167B
gene id: 9823:FAM167B
uniprot id: A0A4X1VZD3
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9823:PCYOX1
gene id: 9823:PCYOX1
uniprot id: A0A8D1RI20
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9823:SPDYA
gene id: 9823:SPDYA
uniprot id: Q4R1K5
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9823:LPCAT1
gene id: 9823:LPCAT1
uniprot id: A0A4X1TM25
uniprot id: F1S029
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9823:WNT2
gene id: 9823:WNT2
uniprot id: A0A287B4Y7
uniprot id: A0A4X1W5H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:PHB2
gene id: 9823:PHB2
uniprot id: A0A4X1UWE0
uniprot id: I3LQN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9823:LOC100524475
gene id: 9823:LOC100524475
uniprot id: A0A287AMQ0
uniprot id: A0A480U313
uniprot id: A0A4X1VZT1
uniprot id: A0A8D1RV76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9823:FBN1
gene id: 9823:FBN1
uniprot id: Q9TV36
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibrillin family.
messages: Cleavage of N- and C-terminus by furin is required for incorporation into the extracellular matrix and assembly into microfibrils. The C-terminus, which corresponds to the Asprosin chain, was initially thought to constitute a propeptide. Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin, an essential step for incorporation of Fibrillin-1 into the nascent microfibrils.
messages: Forms intermolecular disulfide bonds either with other fibrillin-1 molecules or with other components of the microfibrils.
messages: Hormone that targets the liver to increase plasma glucose levels. Secreted by white adipose tissue and circulates in the plasma. Acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepatocytes. Promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation.
messages: Interacts with COL16A1. Interacts with integrin alpha-V/beta-3. Interacts with ADAMTS10; this interaction promotes microfibril assembly. Interacts with THSD4; this interaction promotes fibril formation. Interacts (via N-terminal domain) with FBLN2 and FBLN5. Interacts with ELN. Forms a ternary complex with ELN and FBLN2 or FBLN5 and a significant interaction with ELN seen only in the presence of FBLN2 or FBLN5. Interacts (via N-terminal domain) with LTBP2 (via C-terminal domain) in a Ca(+2)-dependent manner. Interacts (via N-terminal domain) with LTBP1 (via C-terminal domain). Interacts with integrins ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. Interacts (via N-terminal domain) with BMP2, BMP4, BMP7, BMP10 and GDF5. Interacts (via N-terminal domain) with MFAP2 and MFAP5. Interacts with ADAMTSL5. Interacts with MFAP4. Interacts (via N-terminal domain) with TNFSF11 in a Ca(+2)-dependent manner. Interacts (via N-terminal domain) with EFEMP2; this interaction inhibits EFEMP2 binding to LOX and ELN (By similarity).
messages: O-glycosylated on serine residues by POGLUT2 and POGLUT3 which is necessary for efficient protein secretion.
messages: Secreted
messages: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function. Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils.
messages: extracellular matrix

9823:AKR1CL1
gene id: 9823:AKR1CL1
uniprot id: Q2TJA5
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9823:HAX1
gene id: 9823:HAX1
uniprot id: A0A481BZY7
uniprot id: A0A8D0XZN0
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

9823:GPBP1
gene id: 9823:GPBP1
uniprot id: A0A4X1SH74
uniprot id: A0A5G2QDA7
uniprot id: A0A8D1EWD9
uniprot id: F1SLJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9823:ZNF687
gene id: 9823:ZNF687
uniprot id: A0A8D0MH80
uniprot id: F1SSZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9823:HOXA4
gene id: 9823:HOXA4
uniprot id: A0A4X1TUD9
uniprot id: F1SHT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:S100A16
gene id: 9823:S100A16
uniprot id: A0A8D1VNY4
uniprot id: F2Z5M4
names: Similarity
messages: Belongs to the S-100 family.

9823:GRIA3
gene id: 9823:GRIA3
uniprot id: A0A4X1W0Q9
uniprot id: A0A4X1W7X5
uniprot id: K7GKW9
uniprot id: K7GPI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9823:LEPR
gene id: 9823:LEPR
uniprot id: O02671
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Kidney, liver, spleen, lung, brain, testis, uterus, ovary, corpus luteum, theca and granulosa cells.
messages: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Phosphorylation of Tyr-1079 has a more accessory role.
messages: Present as a mixture of monomers and dimers. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (By similarity).
messages: Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.

9823:RPL39
gene id: 9823:RPL39
uniprot id: A0A4X1VIM4
uniprot id: K7GP63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9823:DNASE2
gene id: 9823:DNASE2
uniprot id: O62855
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase II family.
messages: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells.
messages: Lysosome

9823:LOC100523805
gene id: 9823:LOC100523805
uniprot id: A0A4X1TIF6
uniprot id: F1S5X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SMC1A
gene id: 9823:SMC1A
uniprot id: A0A287B9V7
uniprot id: A0A4X1SXG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9823:DYNC1I2
gene id: 9823:DYNC1I2
uniprot id: A0A4X1VH50
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9823:IL15RA
gene id: 9823:IL15RA
uniprot id: A0A4X1T6U0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:EIF2S1
gene id: 9823:EIF2S1
uniprot id: A0A287A096
uniprot id: A0A4X1U4D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9823:LOC100517166
gene id: 9823:LOC100517166
uniprot id: A0A480ZG93
uniprot id: A0A4X1SG73
names: Similarity
messages: Belongs to the TMEM14 family.

9823:LOC100624358
gene id: 9823:LOC100624358
uniprot id: A0A8D1RET2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SNAP91
gene id: 9823:SNAP91
uniprot id: A0A4X1V5R8
uniprot id: A0A8D0IND4
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9823:ARF4
gene id: 9823:ARF4
uniprot id: A0A4X1VJ91
uniprot id: Q56P20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9823:FLT3
gene id: 9823:FLT3
uniprot id: A0A4X1TMR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Membrane

9823:ADH5
gene id: 9823:ADH5
uniprot id: A0A4X1UEX6
uniprot id: F1S0C1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9823:HSPH1
gene id: 9823:HSPH1
uniprot id: A4UTN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9823:ERO1A
gene id: 9823:ERO1A
uniprot id: B6CVD7
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: Enzyme activity is tightly regulated to prevent the accumulation of reactive oxygen species in the endoplasmic reticulum. Reversibly down-regulated by the formation of disulfide bonds between the active site Cys-94 and Cys-131, and between Cys-99 and Cys-104. Glutathione may be required to regulate its activity in the endoplasmic reticulum (By similarity).
messages: Golgi apparatus lumen
messages: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
messages: Phosphorylated on Ser-145 by FAM20C in the Golgi which increases its enzymatic activity (By similarity). Phosphorylation is induced by lactation (By similarity). It is also induced by hypoxia and reductive stress (By similarity).
messages: Predominantly monomer. May function both as a monomer and a homodimer. Interacts with PDILT. Interacts with ERP44; the interaction results in retention of ERO1A in the endoplasmic reticulum.
messages: Secreted
messages: The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397. The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-131 (By similarity).
messages: dendrite

9823:EGF
gene id: 9823:EGF
uniprot id: Q00968
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
messages: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity). Interacts with RHBDF2 (By similarity).
messages: Membrane

9823:IFITM1
gene id: 9823:IFITM1
uniprot id: A9QW81
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:EEF2KMT
gene id: 9823:EEF2KMT
uniprot id: A0A480JY15
uniprot id: A0A4X1VRN1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

9823:CALCRL
gene id: 9823:CALCRL
uniprot id: A0A287A7L3
uniprot id: A0A4X1TUL8
uniprot id: Q8WN93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Detected in lung and coronary artery.
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2 (By similarity).
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9823:HHEX
gene id: 9823:HHEX
uniprot id: A0A286ZN76
uniprot id: A0A4X1UY77
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100359361
gene id: 9823:LOC100359361
uniprot id: A0A8D1DVY9
uniprot id: D3K5K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9823:PRPF38B
gene id: 9823:PRPF38B
uniprot id: A0A480K054
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9823:EMC7
gene id: 9823:EMC7
uniprot id: A0A4X1US46
uniprot id: I3LRK6
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

9823:ECSIT
gene id: 9823:ECSIT
uniprot id: A0A4X1VMR6
uniprot id: A0A8D1MF45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

9823:PGAP3
gene id: 9823:PGAP3
uniprot id: A0A480QBF6
uniprot id: A0A4X1UFA8
uniprot id: A0A8D0WV04
uniprot id: F1RWL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:ALOX5AP
gene id: 9823:ALOX5AP
uniprot id: A0A4X1TIT9
uniprot id: F1RST5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LOC102167894
gene id: 9823:LOC102167894
uniprot id: A0A0G3VQE0
uniprot id: A0A4X1TRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:ATP2B1
gene id: 9823:ATP2B1
uniprot id: P23220
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.
messages: Cell membrane
messages: Monomer. Dimer. Oligomer. Calmodulin binding. Interacts with PDZD11. Interacts with SLC35G1 and STIM1. Interacts with YWHAE; interacts with the monomeric and dimeric forms of the YWHAE but prefer the monomer form; this interaction inhibits calcium-transporting ATPase activity (By similarity). Interacts with NPTN; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation. Interacts with EPB41; regulates small intestinal calcium absorption through regulation of membrane expression of ATP2B1 (By similarity).
messages: Presynaptic cell membrane
messages: Synapse
messages: synaptic vesicle membrane

9823:ANP32A
gene id: 9823:ANP32A
uniprot id: A0A4X1T6H6
uniprot id: F1SIV3
names: Similarity
messages: Belongs to the ANP32 family.

9823:LOC100525388
gene id: 9823:LOC100525388
uniprot id: A0A287AP42
uniprot id: A0A4X1SNJ4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:PIGV
gene id: 9823:PIGV
uniprot id: A0A4X1UQU6
uniprot id: F1STS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9823:PRMT5
gene id: 9823:PRMT5
uniprot id: A0A4X1V2M8
uniprot id: A0A8D0I970
uniprot id: C3RZ98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9823:GIMAP6
gene id: 9823:GIMAP6
uniprot id: A0A8D0RWE0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9823:TP23
gene id: 9823:TP23
uniprot id: Q95JC9
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acinar cells and secretory granules of the parotid gland.
messages: Secreted
messages: The parotid hormone stimulates dentinal fluid transport in teeth.

9823:NCOA2
gene id: 9823:NCOA2
uniprot id: B0FRD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9823:PLA2G5
gene id: 9823:PLA2G5
uniprot id: A0A286ZX54
uniprot id: A0A4X1W493
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9823:ARSK
gene id: 9823:ARSK
uniprot id: A0A8D1XHU3
uniprot id: F1REY9
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9823:SCN3B
gene id: 9823:SCN3B
uniprot id: A0A480L113
uniprot id: A0A4X1VHU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9823:MRPL18
gene id: 9823:MRPL18
uniprot id: A0A0R4J8D5
uniprot id: A0A4X1VQG2
uniprot id: A0A4X1VX01
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9823:RPS5
gene id: 9823:RPS5
uniprot id: A0A4X1W3K3
uniprot id: F2Z5E6
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9823:CAVIN2
gene id: 9823:CAVIN2
uniprot id: A0A4X1SGA2
uniprot id: I3LDR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9823:HMGB3
gene id: 9823:HMGB3
uniprot id: A0A287BHQ2
uniprot id: A0A4X1SYN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9823:PIK3R1
gene id: 9823:PIK3R1
uniprot id: A0A4X1UM36
uniprot id: F1SKR9
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9823:TADA3
gene id: 9823:TADA3
uniprot id: A0A4X1UWQ3
uniprot id: F1SQF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9823:CLIC6
gene id: 9823:CLIC6
uniprot id: A0A8D1I5J4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9823:CCR1
gene id: 9823:CCR1
uniprot id: A0A8D0TYM0
uniprot id: Q6YST0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9823:RHOT2
gene id: 9823:RHOT2
uniprot id: Q864R5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (By similarity). Interacts with ARMCX3 (By similarity). Found in a complex with KIF5B, OGT, RHOT1 and TRAK1 (By similarity).
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.

9823:CXXC1
gene id: 9823:CXXC1
uniprot id: A0A4X1UJF4
uniprot id: A0A4X1UKR5
uniprot id: F1RPP3
names: Subcellular Location Annotation
messages: Nucleus

9823:GABRA2
gene id: 9823:GABRA2
uniprot id: A0A4X1ULV0
uniprot id: A0A5G2R7L6
uniprot id: A0A8D1B5M6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9823:MTX1
gene id: 9823:MTX1
uniprot id: Q27HK4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metaxin family.
messages: Interacts with MTX2/metaxin-2 (By similarity). Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13 (By similarity). This complex was also known under the names MINOS or MitOS complex (By similarity). The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity). Interacts with ARMC1 (By similarity).
messages: Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

9823:SUPT5H
gene id: 9823:SUPT5H
uniprot id: A0A8D1JAK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9823:CCNI
gene id: 9823:CCNI
uniprot id: A0A4X1SUM8
uniprot id: F1RYS4
names: Similarity
messages: Belongs to the cyclin family.

9823:PDZD11
gene id: 9823:PDZD11
uniprot id: Q6QA76
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with ATP2B1, ATP2B2, ATP2B3, ATP2B4 and ATP7A (By similarity). Interacts with PLEKHA7 (via WW domains) at zonula adherens; this interaction is essential for the interaction between PLEKHA7 and the ADAM10-binding protein TSPAN33 (By similarity). Interacts with SLC5A6 (By similarity).
messages: Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.
messages: adherens junction

9823:OSTC
gene id: 9823:OSTC
uniprot id: A0A4X1UWE1
uniprot id: F2Z5C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9823:VPS16
gene id: 9823:VPS16
uniprot id: A0A480V3F0
uniprot id: A0A4X1SGW4
uniprot id: A0A8D0U823
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9823:CFAP36
gene id: 9823:CFAP36
uniprot id: A0A4X1WBS2
uniprot id: F1SQK9
names: Similarity
messages: Belongs to the CFAP36 family.

9823:WNT7A
gene id: 9823:WNT7A
uniprot id: A0A287AGQ6
uniprot id: A0A8D2C3X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:PIGK
gene id: 9823:PIGK
uniprot id: Q4KRV1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity).
messages: The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity.

9823:MEPCE
gene id: 9823:MEPCE
uniprot id: A0A480IT56
uniprot id: A0A4X1U8N9
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9823:FUT2A
gene id: 9823:FUT2A
uniprot id: A0A286ZSY8
uniprot id: A0A287AFT2
uniprot id: A0A8D0R283
uniprot id: A0A8D0R5Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9823:BCO2
gene id: 9823:BCO2
uniprot id: A0A8D1QGF1
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9823:HAO1
gene id: 9823:HAO1
uniprot id: A0A4X1UK18
uniprot id: I3LVF1
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9823:RPS25
gene id: 9823:RPS25
uniprot id: A0A4X1SLJ1
uniprot id: F2Z5G8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

9823:TRIM9
gene id: 9823:TRIM9
uniprot id: A0A4X1SDQ9
uniprot id: A0A4X1SDS7
uniprot id: A0A4X1SDU8
uniprot id: A0A8D0PV30
uniprot id: F1SFF7
names: Subcellular Location Annotation
messages: cytoskeleton

9823:LOXL1
gene id: 9823:LOXL1
uniprot id: A0A4X1TM40
uniprot id: F1SIC9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9823:LOC100512836
gene id: 9823:LOC100512836
uniprot id: A0A8D1LVN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLC1A2
gene id: 9823:SLC1A2
uniprot id: A0A287AK79
uniprot id: A0A4X1SM79
uniprot id: A0A4X1SNF2
uniprot id: A0A8D0KDN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9823:MARVELD2
gene id: 9823:MARVELD2
uniprot id: A0A8D1IQC5
uniprot id: F1SKR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9823:BDKRB2
gene id: 9823:BDKRB2
uniprot id: A0A8D1LZD7
uniprot id: Q9GLX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1 (By similarity).
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9823:XRN2
gene id: 9823:XRN2
uniprot id: A0A4X1V3A4
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9823:ADRA1D
gene id: 9823:ADRA1D
uniprot id: Q9TTM9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Palmitoylated. Palmitoylation by ZDHHC21 may increase the expression of the receptor and regulate downstream signaling.
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9823:LPAR3
gene id: 9823:LPAR3
uniprot id: A0A4X1UZI6
uniprot id: C5G5X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:ARF5
gene id: 9823:ARF5
uniprot id: A0A4X1W2D8
uniprot id: B9V4F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9823:LOC100512888
gene id: 9823:LOC100512888
uniprot id: A0A286ZR67
uniprot id: A0A8D1FP05
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:RPP30
gene id: 9823:RPP30
uniprot id: A0A5G2QIB1
uniprot id: A0A8D1R6B1
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9823:RNF8
gene id: 9823:RNF8
uniprot id: A0A4X1SS01
uniprot id: A0A4X1SSS0
uniprot id: A0A4X1SST0
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9823:METTL11B
gene id: 9823:METTL11B
uniprot id: A0A287B4H2
uniprot id: A0A4X1UK40
uniprot id: A0A8D1IP54
uniprot id: F1RSD2
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9823:NDFIP2
gene id: 9823:NDFIP2
uniprot id: A0A4X1V1A8
uniprot id: F1RP69
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9823:ATP6V0C
gene id: 9823:ATP6V0C
uniprot id: A0A4X1VUN6
uniprot id: A0A5G2QWF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9823:AK3
gene id: 9823:AK3
uniprot id: A0A4X1W814
uniprot id: A0A5G2QPK4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9823:STX5
gene id: 9823:STX5
uniprot id: A0A480M212
uniprot id: A0A4X1VMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9823:CD28
gene id: 9823:CD28
uniprot id: A0A4X1V5B4
uniprot id: I3LKR6
names: Subcellular Location Annotation
messages: Membrane

9823:XRCC4
gene id: 9823:XRCC4
uniprot id: A0A4X1T9C8
uniprot id: A0A4X1TA24
uniprot id: A0A8D0X3J2
uniprot id: F1REZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

9823:KRR1
gene id: 9823:KRR1
uniprot id: A0A287BCI5
uniprot id: A0A8D1Y528
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9823:ATP6V0A2
gene id: 9823:ATP6V0A2
uniprot id: A0A480UG97
uniprot id: A0A4X1UMB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9823:SPOPL
gene id: 9823:SPOPL
uniprot id: A0A287AS40
uniprot id: A0A287BRB8
uniprot id: A0A4X1SXV1
uniprot id: A0A4X1T001
names: Similarity
messages: Belongs to the Tdpoz family.

9823:XIRP2
gene id: 9823:XIRP2
uniprot id: A0A287AHZ3
uniprot id: A0A8D0S7S9
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9823:PAQR8
gene id: 9823:PAQR8
uniprot id: A0A481C806
uniprot id: Q865K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Cell membrane
messages: Membrane
messages: Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity).

9823:KPNA5
gene id: 9823:KPNA5
uniprot id: A0A4X1TCK2
uniprot id: A0A4X1TD58
uniprot id: F1RTU5
uniprot id: I3LUT7
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9823:MGAT2
gene id: 9823:MGAT2
uniprot id: O19071
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.

9823:GDF7
gene id: 9823:GDF7
uniprot id: I3LB35
names: Similarity
messages: Belongs to the TGF-beta family.

9823:ADD1
gene id: 9823:ADD1
uniprot id: K9J6I7
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9823:LSM14A
gene id: 9823:LSM14A
uniprot id: A0A8D0P6Z5
uniprot id: R4JU57
names: Similarity
messages: Belongs to the LSM14 family.

9823:PLA2G1B
gene id: 9823:PLA2G1B
uniprot id: P00592
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
messages: Acylation causes dimerization.
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Loss of activity upon alkylation of His-70 with p-bromo phenacyl bromide; Ca(2+) and Ba(2+) protect against inactivation.
messages: Monomer or homodimer.
messages: Regulated by bile acid salts. Up-regulated by cholate and down-regulated by taurochenodeoxycholate.
messages: Secreted
messages: Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (By similarity). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).

9823:FAM163B
gene id: 9823:FAM163B
uniprot id: A0A4X1SY60
uniprot id: I3LTY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9823:SHQ1
gene id: 9823:SHQ1
uniprot id: A0A4X1V8R1
uniprot id: F1SFN0
names: Similarity
messages: Belongs to the SHQ1 family.

9823:HOXB13
gene id: 9823:HOXB13
uniprot id: A0A4X1UR05
uniprot id: F1RWF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9823:CD14
gene id: 9823:CD14
uniprot id: A7BG66
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft
messages: Secreted

9823:DHH
gene id: 9823:DHH
uniprot id: A0A4X1WCP1
uniprot id: F1SJ10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9823:LOC100515945
gene id: 9823:LOC100515945
uniprot id: A0A4X1SS04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ATP6V1A
gene id: 9823:ATP6V1A
uniprot id: Q29048
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP hydrolysis occurs at the interface between the nucleotide-binding domains of subunits A and B (By similarity). ATP hydrolysis triggers a conformational change in the subunits D and F, which induces a shift of subunit d (By similarity). The c-ring is subsequently rotated and results in a continuous proton translocation across the membrane (By similarity).
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity).
messages: Cytoplasm
messages: Lysosome
messages: Phosphorylation at Ser-384 by AMPK down-regulates its enzyme activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with the V0 complex V-ATPase subunit a4 ATP6V0A4 (By similarity). Interacts with WFS1 (By similarity). Interacts with alpha-crystallin B chain/CRYAB and with MTOR, forming a ternary complex (By similarity).
messages: clathrin-coated vesicle membrane
messages: cytosol
messages: secretory vesicle

9823:TNFSF12
gene id: 9823:TNFSF12
uniprot id: A0A4X1V0D2
uniprot id: A9Q749
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:CMTM7
gene id: 9823:CMTM7
uniprot id: A0A8D1AA82
names: Subcellular Location Annotation
messages: Membrane

9823:CLDN7
gene id: 9823:CLDN7
uniprot id: A0A4X1V1Z7
uniprot id: C3VPJ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9823:DACT3
gene id: 9823:DACT3
uniprot id: I3LKG3
names: Similarity
messages: Belongs to the dapper family.

9823:RAB14
gene id: 9823:RAB14
uniprot id: A0A4X1UKV3
uniprot id: Q52NJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with KIF16B. Interacts with ZFYVE20 (By similarity).
messages: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity).
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9823:TMEM107
gene id: 9823:TMEM107
uniprot id: A0A8D0JTK5
uniprot id: I3LUH9
names: Subcellular Location Annotation
messages: Membrane

9823:METAP2
gene id: 9823:METAP2
uniprot id: A0A4X1SJM8
uniprot id: I3LSP1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9823:KIF5C
gene id: 9823:KIF5C
uniprot id: A0A480PZV2
uniprot id: A0A4X1THT2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:ATP6V1B2
gene id: 9823:ATP6V1B2
uniprot id: A0A480UKG6
uniprot id: A0A4X1VDG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9823:ZNF24
gene id: 9823:ZNF24
uniprot id: A0A4X1VB65
uniprot id: I3LAF2
names: Subcellular Location Annotation
messages: Nucleus

9823:PROX1
gene id: 9823:PROX1
uniprot id: A0A4X1TJW3
uniprot id: B3F172
uniprot id: F1S2Y2
names: Subcellular Location Annotation
messages: Nucleus

9823:TRAPPC3
gene id: 9823:TRAPPC3
uniprot id: A0A480T9W5
uniprot id: A0A4X1VS55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9823:ZC2HC1C
gene id: 9823:ZC2HC1C
uniprot id: A0A4X1T926
uniprot id: F1S2Q5
names: Similarity
messages: Belongs to the ZC2HC1 family.

9823:SH3GL2
gene id: 9823:SH3GL2
uniprot id: A0A8D0SB37
uniprot id: F1SNE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9823:SCGB1D1
gene id: 9823:SCGB1D1
uniprot id: Q863D3
names: Subcellular Location Annotation
messages: Secreted

9823:ADAMTS20
gene id: 9823:ADAMTS20
uniprot id: H9BR48
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:RPL35A
gene id: 9823:RPL35A
uniprot id: A0A286ZLH8
uniprot id: A0A4X1TPT1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9823:ATG9B
gene id: 9823:ATG9B
uniprot id: D7RA33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9823:CYP1A2
gene id: 9823:CYP1A2
uniprot id: A0A4X1TKW5
uniprot id: F1SJ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9823:MEMO1
gene id: 9823:MEMO1
uniprot id: A0A4X1T9V9
uniprot id: F2Z5F8
names: Similarity
messages: Belongs to the MEMO1 family.

9823:EIF4E1B
gene id: 9823:EIF4E1B
uniprot id: A0A480EPA0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9823:MUM1L1
gene id: 9823:MUM1L1
uniprot id: A0A4X1STR3
uniprot id: F1RXM4
names: Similarity
messages: Belongs to the PWWP3A family.

9823:HK3
gene id: 9823:HK3
uniprot id: A0A287AE54
uniprot id: A0A4X1SIK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9823:SLC30A6
gene id: 9823:SLC30A6
uniprot id: A0A4X1TAP4
uniprot id: B6V6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9823:PDCD5
gene id: 9823:PDCD5
uniprot id: A0A481D4P9
uniprot id: A0A4X1TUT8
names: Similarity
messages: Belongs to the PDCD5 family.

9823:SETD7
gene id: 9823:SETD7
uniprot id: I3LI15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9823:AKR1A1
gene id: 9823:AKR1A1
uniprot id: P50578
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Displays no reductase activity towards retinoids (PubMed:12732097).
messages: Monomer.
messages: cytosol

9823:IFN-DELTA-9
gene id: 9823:IFN-DELTA-9
uniprot id: C8CKB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:FAM131A
gene id: 9823:FAM131A
uniprot id: A0A4X1UIP4
uniprot id: A0A4X1UNU6
names: Similarity
messages: Belongs to the FAM131 family.

9823:RAD18
gene id: 9823:RAD18
uniprot id: A0A4X1V2L4
uniprot id: B7TJ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9823:PLK4
gene id: 9823:PLK4
uniprot id: A0A480V3H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cleavage furrow
messages: centriole

9823:SDC4
gene id: 9823:SDC4
uniprot id: A0A480JRC1
uniprot id: Q8HZJ6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
messages: Cell surface proteoglycan.
messages: Homodimer. Interacts with CDCP1 and SDCBP. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity).
messages: Membrane
messages: Secreted
messages: Shedding, cleavage of the extracellular domain to release a soluble form, is enhanced by a number of factors such as heparanase, growth factor receptor action for example by thrombin or EGF. Physiological events such as stress or wound healing can activate the shedding. PMA-mediated shedding is inhibited by TIMP3 (By similarity).

9823:EFHB
gene id: 9823:EFHB
uniprot id: A0A8D1W322
uniprot id: F1RS61
names: Subcellular Location Annotation
messages: cilium axoneme

9823:KIAA1024
gene id: 9823:KIAA1024
uniprot id: A0A8D1L4W4
uniprot id: F1RKQ2
names: Similarity
messages: Belongs to the MINAR family.

9823:LIG4
gene id: 9823:LIG4
uniprot id: A0A8D1Q102
uniprot id: F1RLP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9823:MYL9
gene id: 9823:MYL9
uniprot id: P29269
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin heavy chain MYO19.
messages: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity).
messages: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is required for myotube formation.
messages: Smooth muscle tissues and in some, but not all, nonmuscle cells.
messages: This chain binds calcium.
messages: cell cortex
messages: cytoskeleton

9823:BORCS8
gene id: 9823:BORCS8
uniprot id: A0A4X1U346
uniprot id: A0A4X1U5U8
uniprot id: A0A5G2QFU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9823:SPIN3
gene id: 9823:SPIN3
uniprot id: A0A480RFK2
uniprot id: A0A4X1VJK4
names: Similarity
messages: Belongs to the SPIN/STSY family.

9823:LOC100513868
gene id: 9823:LOC100513868
uniprot id: A0A4X1SU74
uniprot id: A0A4X1SUH9
uniprot id: K7N7E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9823:CDH1
gene id: 9823:CDH1
uniprot id: C6EVT4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
messages: Membrane
messages: trans-Golgi network

9823:RNASEK
gene id: 9823:RNASEK
uniprot id: A0A4X1V086
uniprot id: F1RF51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Membrane

9823:BCAN
gene id: 9823:BCAN
uniprot id: A0A8D0QRR0
uniprot id: F1RP38
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9823:FAM49B
gene id: 9823:FAM49B
uniprot id: A0A8D0HXM4
uniprot id: F1RRT3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9823:BMP4
gene id: 9823:BMP4
uniprot id: A0A4X1WD52
uniprot id: A7LJT9
names: Similarity
messages: Belongs to the TGF-beta family.

9823:GPR4
gene id: 9823:GPR4
uniprot id: P50132
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)/H(+).

9823:CCL2
gene id: 9823:CCL2
uniprot id: B3GDZ4
uniprot id: P42831
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Monomer or homodimer; in equilibrium. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Interacts with TNFAIP6 (via Link domain).
messages: N-Glycosylated.
messages: Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).
messages: Secreted

9823:TAF13
gene id: 9823:TAF13
uniprot id: A0A4X1TGR0
uniprot id: F1S5Y9
names: Subcellular Location Annotation
messages: Nucleus

9823:PSMC6
gene id: 9823:PSMC6
uniprot id: A0A286ZXG4
uniprot id: A0A4X1W7V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9823:NIP7
gene id: 9823:NIP7
uniprot id: Q56P27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NIP7 family.
messages: Expressed in muscle, heart, liver, fat, kidney and lung. Weakly expressed in small intestine, ovary and spleen.
messages: Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 (By similarity).
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9823:DES
gene id: 9823:DES
uniprot id: P02540
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylation prevents ability to form intermediate filaments.
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Homomer. Interacts with DST. Interacts with MTM1. Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament. Interacts with CRYAB. Interacts with NEB (via nebulin repeats 160-164). Interacts (via rod region) with NEBL (via nebulin repeats 1-5). Interacts with ASB2; the interaction targets DES for proteasomal degradation (By similarity). Interacts with PKP1 (By similarity).
messages: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin.
messages: Nucleus
messages: Phosphorylation at Ser-7, Ser-28 and Ser-32 by CDK1 and phosphorylation at Ser-60 by AURKB contribute to efficient separation of desmin intermediate filaments during mitosis.
messages: Ubiquitination by a SCF-like complex containing ASB2 leads to proteasomal degradation.
messages: Z line
messages: sarcolemma

9823:NME3
gene id: 9823:NME3
uniprot id: A0A4X1VZ23
uniprot id: A0A8D1WEU5
uniprot id: F1RG17
names: Similarity
messages: Belongs to the NDK family.

9823:NSFL1C
gene id: 9823:NSFL1C
uniprot id: A0A4X1SK04
uniprot id: A0A4X1SL19
uniprot id: A0A5G2R8G1
uniprot id: A0A8D1VX36
uniprot id: F1S880
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9823:MMAB
gene id: 9823:MMAB
uniprot id: A0A481CLS2
uniprot id: A0A4X1T125
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

9823:BTG1
gene id: 9823:BTG1
uniprot id: A0A4X1SGU2
uniprot id: A5YRP0
names: Function
names: Similarity
messages: Anti-proliferative protein.
messages: Belongs to the BTG family.

9823:NTN4
gene id: 9823:NTN4
uniprot id: F1SQR3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:EXOSC2
gene id: 9823:EXOSC2
uniprot id: A0A480QLF8
uniprot id: A0A4X1TET0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9823:NUCB1
gene id: 9823:NUCB1
uniprot id: A0A286ZVT6
uniprot id: A0A4X1W1D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobindin family.
messages: Cytoplasm
messages: Secreted
messages: cis-Golgi network membrane

9823:SGCA
gene id: 9823:SGCA
uniprot id: A0A4X1URV3
uniprot id: B8Y4S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton

9823:LTN1
gene id: 9823:LTN1
uniprot id: A0A8D0UBX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

9823:APPL1
gene id: 9823:APPL1
uniprot id: A0A4X1VJU7
uniprot id: B5LX40
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9823:SERPINA3-2
gene id: 9823:SERPINA3-2
uniprot id: Q9GMA6
names: Similarity
messages: Belongs to the serpin family.

9823:WNT1
gene id: 9823:WNT1
uniprot id: A0A4X1WCQ6
uniprot id: F1SJ15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9823:PCYT1A
gene id: 9823:PCYT1A
uniprot id: A0A287AI63
uniprot id: A0A287B3H6
uniprot id: A0A4X1TX36
uniprot id: A0A8D0RSH4
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9823:AKAP5
gene id: 9823:AKAP5
uniprot id: A0A4X1UEK5
uniprot id: F1SA75
names: Subcellular Location Annotation
messages: Membrane

9823:CCNK
gene id: 9823:CCNK
uniprot id: A0A480QNH9
names: Similarity
messages: Belongs to the cyclin family.

9823:PRF1
gene id: 9823:PRF1
uniprot id: A0A4X1TDP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9823:MTHFD1
gene id: 9823:MTHFD1
uniprot id: A0A4X1UGR4
uniprot id: F1SA74
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9823:CENPC
gene id: 9823:CENPC
uniprot id: A0A8D1WY36
uniprot id: A0A8D2BVG7
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

9823:LSM1
gene id: 9823:LSM1
uniprot id: A0A287B8U6
uniprot id: A0A4X1VW00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9823:LOC100515394
gene id: 9823:LOC100515394
uniprot id: A0A8D1IIM8
uniprot id: I3LC60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9823:LOC100520248
gene id: 9823:LOC100520248
uniprot id: A0A4X1STM9
names: Subcellular Location Annotation
messages: Nucleus

9823:PAX6
gene id: 9823:PAX6
uniprot id: A0A287AAF3
uniprot id: A0A4X1SV95
uniprot id: A0A4X1SWS9
uniprot id: F2Z5M7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:MYH4
gene id: 9823:MYH4
uniprot id: Q9TV62
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-4 (MYO4).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9823:TXNRD2
gene id: 9823:TXNRD2
uniprot id: D2K6G0
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

9823:MAP2K4
gene id: 9823:MAP2K4
uniprot id: A0A5G2QJE6
uniprot id: A0A8D1CWD0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:RAB1A
gene id: 9823:RAB1A
uniprot id: Q52NJ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: May interact with YIPF5. Interacts with C9orf72; the interaction mediates recruitment of RAB1A to the ATG1/ULK1 kinase complex. Interacts with GDI1; this promotes dissociation from membranes.
messages: Melanosome
messages: Membrane
messages: Phosphorylated by CDK1 kinase during mitosis.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Required to modulate the compacted morphology of the Golgi (By similarity). Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity).
messages: cytosol

9823:STX7
gene id: 9823:STX7
uniprot id: A0A5G2QD51
names: Similarity
messages: Belongs to the syntaxin family.

9823:DUSP6
gene id: 9823:DUSP6
uniprot id: A0A287AJD2
uniprot id: A0A4X1SDH2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9823:RAB9B
gene id: 9823:RAB9B
uniprot id: A0A287BH53
uniprot id: A0A4X1W519
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9823:SNUPN
gene id: 9823:SNUPN
uniprot id: A0A4X1TQ71
uniprot id: A0A8D1F4K3
uniprot id: F1SJ72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

9823:NDUFS1
gene id: 9823:NDUFS1
uniprot id: A0A4X1V1H9
uniprot id: F1SHD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

9823:TNFRSF9
gene id: 9823:TNFRSF9
uniprot id: A0A288CFZ9
uniprot id: A0A4X1W2S3
uniprot id: A0A5K1VKG5
uniprot id: A0A8D2CEL2
uniprot id: F1RII3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:PSMG2
gene id: 9823:PSMG2
uniprot id: A0A286ZXX4
uniprot id: A0A4X1VNT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9823:NEMF
gene id: 9823:NEMF
uniprot id: A0A4X1SIJ6
uniprot id: F1SHY2
names: Similarity
messages: Belongs to the NEMF family.

9823:PRPF31
gene id: 9823:PRPF31
uniprot id: A0A287AMS8
uniprot id: A0A4X1VPB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

9823:MTFR2
gene id: 9823:MTFR2
uniprot id: A0A8D1Y5F9
uniprot id: F1S3R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9823:NPG1
gene id: 9823:NPG1
uniprot id: P32194
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.
messages: Secreted

9823:RNASEH2A
gene id: 9823:RNASEH2A
uniprot id: A0A8D1L2G4
uniprot id: F1SDX8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9823:KIF19
gene id: 9823:KIF19
uniprot id: I3LEH8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9823:GLTP
gene id: 9823:GLTP
uniprot id: P68266
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (By similarity).
messages: Belongs to the GLTP family.
messages: Cytoplasm
messages: Monomer.

9823:ST8SIA2
gene id: 9823:ST8SIA2
uniprot id: A0A4X1UGP8
uniprot id: M1FW61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:POLL
gene id: 9823:POLL
uniprot id: A0A8D1ZJX7
uniprot id: F1S8U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9823:TMED3
gene id: 9823:TMED3
uniprot id: A0A8D0YZV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9823:B3GNT8
gene id: 9823:B3GNT8
uniprot id: A0A286ZLM1
uniprot id: A0A8D0QP03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:GDF11
gene id: 9823:GDF11
uniprot id: E7ECV9
uniprot id: Q647I3
uniprot id: Q9BG54
names: Similarity
messages: Belongs to the TGF-beta family.

9823:GPR87
gene id: 9823:GPR87
uniprot id: A0A287AN17
uniprot id: A0A4X1SV96
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:COX6B
gene id: 9823:COX6B
uniprot id: A0A287A808
uniprot id: A0A4X1TG97
uniprot id: A1XQT1
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9823:PSMB9
gene id: 9823:PSMB9
uniprot id: A0A4X1V0J8
uniprot id: Q2PYM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:FAM198B
gene id: 9823:FAM198B
uniprot id: A0A480ZIZ9
uniprot id: A0A4X1U4G4
names: Similarity
messages: Belongs to the GASK family.

9823:CXCL12
gene id: 9823:CXCL12
uniprot id: A0A4X1VBG4
uniprot id: A0A5G2QQD0
uniprot id: A0A8D0V261
uniprot id: A0A8D1V9V4
uniprot id: Q6EKW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9823:MYL6
gene id: 9823:MYL6
uniprot id: P60662
names: Function
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with SPATA6.
messages: Regulatory light chain of myosin. Does not bind calcium.

9823:VIPR1
gene id: 9823:VIPR1
uniprot id: A0A4X1TLQ5
uniprot id: D9IWB9
uniprot id: D9IWC2
uniprot id: D9IWC4
uniprot id: Q28992
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane
messages: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).

9823:TP53
gene id: 9823:TP53
uniprot id: A0A1B2TT48
uniprot id: Q9TUB2
names: Cofactor
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of Lys-375 by CREBBP enhances transcriptional activity. Acetylation of Lys-375 by EP300. Deacetylation of Lys-375 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-374 increases stability. Deacetylation at Lys-374 by SIRT6 decreases its stability, thereby regulating cell senescence.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-375) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interactio…
messages: Mitochondrion matrix
messages: Monomethylated at Lys-365 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-363 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-365 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-363. Dimethylated at Lys-366 by EHMT1 and EHMT2. Monomethylated at Lys-375 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-363 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-326 and dimethylated at Arg-328 and Arg-330 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).
messages: Nucleus
messages: PML body
messages: Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-385 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-47, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-47 in response to genotoxic stress. Phosphorylated at Ser-308 and Ser-385 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).
messages: Sumoylated with SUMO1. Sumoylated at Lys-379 by UBC9 (By similarity).
messages: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
messages: Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (By similarity).
messages: centrosome
messages: p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.

9823:COQ5
gene id: 9823:COQ5
uniprot id: A0A4X1T6M2
uniprot id: F1RJK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9823:POU5F1
gene id: 9823:POU5F1
uniprot id: Q9TSV5
names: Biotechnology
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Cytoplasm
messages: ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.
messages: Interacts with PKM. Interacts with WWP2. Interacts with UBE2I and ZSCAN10. Interacts with PCGF1. Interacts with ESRRB; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter; the interaction is DNA independent. Interacts with ZNF322. Interacts with MAPK8 and MAPK9; the interaction allows MAPK8 and MAPK9 to phosphorylate POU5F1 on Ser-355. Interacts (when phosphorylated on Ser-355) with FBXW8. Interacts with FBXW4. Interacts with SOX2 and SOX15; binds synergistically with either SOX2 or SOX15 to DNA (By similarity). Interacts with DDX56 (By similarity).
messages: Nucleus
messages: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
messages: Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The POU-specific domain mediates interaction with PKM.
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
messages: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation.

9823:CALU
gene id: 9823:CALU
uniprot id: A0A480YTG3
uniprot id: A0A4X1W0N3
uniprot id: A0A4X1W352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

9823:DNMT1
gene id: 9823:DNMT1
uniprot id: Q4TTV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9823:PTGR1
gene id: 9823:PTGR1
uniprot id: Q29073
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Down-regulated by nonsteroidal anti-inflammatory drugs diclofenac, indomethacin and niflumic acid.
messages: Monomer or homodimer.
messages: NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:8576264, PubMed:9461497, PubMed:10837478, PubMed:11688989). Preferentially uses NADPH over NADH as cofactor (PubMed:9461497). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:9461497, PubMed:11688989). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (PubMed:8576264, PubMed:8394361). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4 and may promote neutrophil recruitment at the inflammatory site (PubMed:10837478, PubMed:11688989). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity).
messages: Ubiquitously distributed in various tissues and leukocytes, the kidney and liver had the highest enzyme activities.

9823:ING2
gene id: 9823:ING2
uniprot id: A0A4X1VYP4
uniprot id: I3LVN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9823:PSMA2
gene id: 9823:PSMA2
uniprot id: A0A4X1UL20
uniprot id: I3LAB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9823:GDF9
gene id: 9823:GDF9
uniprot id: A0A4X1UVS7
uniprot id: Q6GUA6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9823:BAX
gene id: 9823:BAX
uniprot id: A0A286ZTT0
uniprot id: A0A4X1W1A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9823:CRP
gene id: 9823:CRP
uniprot id: O19062
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).
messages: Found in plasma.
messages: Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).
messages: Secreted
messages: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

9823:FAM221B
gene id: 9823:FAM221B
uniprot id: A0A4X1VT10
uniprot id: F1STB1
names: Similarity
messages: Belongs to the FAM221 family.

9823:GARS
gene id: 9823:GARS
uniprot id: A0A4X1T5Y1
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9823:YPEL5
gene id: 9823:YPEL5
uniprot id: A0A4X1TCI2
uniprot id: F2Z5F6
names: Similarity
messages: Belongs to the yippee family.

9823:LOC100621915
gene id: 9823:LOC100621915
uniprot id: A0A480RS85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:MSRB1
gene id: 9823:MSRB1
uniprot id: A1E952
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
messages: Nucleus
messages: Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(FEM1C) E3 ubiquitin-protein ligase complex.
messages: cytoskeleton

9823:TAC4
gene id: 9823:TAC4
uniprot id: A0A8D1R6X6
uniprot id: I4IYB5
names: Similarity
messages: Belongs to the tachykinin family.

9823:HTR1B
gene id: 9823:HTR1B
uniprot id: Q9GLP5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

9823:LOC100624788
gene id: 9823:LOC100624788
uniprot id: A0A8D0RBI2
uniprot id: A0A8D0RC72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9823:TPMT
gene id: 9823:TPMT
uniprot id: A0A480S0B0
uniprot id: A0A8D1QZ04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9823:FBLN5
gene id: 9823:FBLN5
uniprot id: A0A480ZQ94
uniprot id: A0A4X1SQM2
uniprot id: A0A4X1SRI1
uniprot id: F1SD87
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:MOG
gene id: 9823:MOG
uniprot id: E2JL22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9823:AMHR2
gene id: 9823:AMHR2
uniprot id: A0A480M865
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

9823:PEX3
gene id: 9823:PEX3
uniprot id: A0A287B530
uniprot id: A0A287B8M9
uniprot id: A0A4X1VNE6
uniprot id: A0A4X1VP96
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9823:KEF22 p02
gene id: 9823:KEF22_p02
uniprot id: O79882
uniprot id: Q7IIC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9823:MTRF1L
gene id: 9823:MTRF1L
uniprot id: A0A8D0YTZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9823:KCNAB2
gene id: 9823:KCNAB2
uniprot id: A0A286ZW35
uniprot id: A0A8D1ZFC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: synaptosome

9823:PDLIM3
gene id: 9823:PDLIM3
uniprot id: A0A480QG05
uniprot id: A0A4X1VW11
uniprot id: D3GGC5
uniprot id: Q6QGC0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ACTN2 (By similarity). Forms a heterodimer with PDLIM4 (via LIM domain) (By similarity).
messages: May play a role in the organization of actin filament arrays within muscle cells.
messages: Z line

9823:DERL3
gene id: 9823:DERL3
uniprot id: A0A287B4M0
uniprot id: A0A4X1V0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9823:TMEM80
gene id: 9823:TMEM80
uniprot id: A0A4X1W071
uniprot id: F1RYY4
names: Subcellular Location Annotation
messages: Membrane

9823:ASPA
gene id: 9823:ASPA
uniprot id: B1PK17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus

9823:FAM131B
gene id: 9823:FAM131B
uniprot id: A0A480PUJ1
uniprot id: A0A4X1V0A8
names: Similarity
messages: Belongs to the FAM131 family.

9823:MRPL2
gene id: 9823:MRPL2
uniprot id: A0A287A143
uniprot id: A0A8D0ZZU0
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9823:CAPZA3
gene id: 9823:CAPZA3
uniprot id: A0A4X1V6F2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9823:NDUFAB1
gene id: 9823:NDUFAB1
uniprot id: A0A4X1V0C8
uniprot id: D0G781
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9823:CALR3
gene id: 9823:CALR3
uniprot id: A0A4X1UTP0
uniprot id: F1S9W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9823:CLPTM1
gene id: 9823:CLPTM1
uniprot id: A0A8D0W5V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9823:CDC20
gene id: 9823:CDC20
uniprot id: Q5H7C0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C) (By similarity).
messages: Belongs to the WD repeat CDC20/Fizzy family.
messages: Component of a complex with CDC20, CDC27, SPATC1 and TUBG1 (By similarity). Interacts with NEUROD2 (By similarity). Interacts with dimeric MAD2L1 in its closed conformation form (By similarity). Interacts with BUB1B (By similarity). The phosphorylated form interacts with APC/C (By similarity). Interacts with NINL (By similarity). May interact with MAD2L2 (By similarity). Interacts with CDK5RAP2 (By similarity). Interacts with SIRT2 (By similarity). Interacts with isoform 1 of NEK2 (By similarity). Interacts with HSF1 (via phosphorylated form); this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex (By similarity). Interacts (via the N-terminal substrate-binding domain) with FBXO5 (By similarity). Interacts with CCNF (By similarity).
messages: Dephosphorylated by CTDP1.
messages: Phosphorylated during mitosis (By similarity). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161 (By similarity). Phosphorylated by NEK2 (By similarity).
messages: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity).
messages: Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex (By similarity).
messages: centrosome
messages: spindle pole

9823:GAL3ST1
gene id: 9823:GAL3ST1
uniprot id: A0A287BRU9
uniprot id: A0A4X1VA83
uniprot id: A0A8D1BYN5
uniprot id: F1RPE6
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9823:KCNE3
gene id: 9823:KCNE3
uniprot id: A0A4X1UQL6
uniprot id: Q8MIS1
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9823:HCFC1
gene id: 9823:HCFC1
uniprot id: A0A480J3L4
names: Subcellular Location Annotation
messages: Nucleus

9823:FAM126A
gene id: 9823:FAM126A
uniprot id: A0A4X1T577
uniprot id: A0A4X1T583
uniprot id: F1SBZ3
uniprot id: I3LJX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9823:BID
gene id: 9823:BID
uniprot id: A0A287AYM3
uniprot id: Q4JHS0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2. Interacts with PLEKHN1.
messages: Induces caspase activation and apoptosis (By similarity). Allows the release of cytochrome c (By similarity).
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Interacts with ITCH (By similarity). Interacts with MTCH2 (By similarity).
messages: Membrane
messages: Mitochondrion membrane
messages: Mitochondrion outer membrane
messages: TNF-alpha induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products (By similarity). Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis (By similarity).
messages: Ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.

9823:DDX6
gene id: 9823:DDX6
uniprot id: A0A287AZJ4
uniprot id: A0A4X1SLL7
uniprot id: A0A4X1SMT0
uniprot id: F1SAJ5
names: Similarity
messages: Belongs to the DEAD box helicase family.

9823:CEP19
gene id: 9823:CEP19
uniprot id: A0A4X1TSU1
uniprot id: I3LFS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9823:AMD1
gene id: 9823:AMD1
uniprot id: A0A4X1VBX0
uniprot id: F1RT08
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9823:CNOT6
gene id: 9823:CNOT6
uniprot id: A0A287A1V1
uniprot id: A0A287B6C8
uniprot id: A0A4X1VVT4
uniprot id: A0A8D0Q4J7
uniprot id: A0A8D1XGJ1
uniprot id: F1S5Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9823:MT-2B
gene id: 9823:MT-2B
uniprot id: P79379
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Interacts with EOLA1.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

9823:RALY
gene id: 9823:RALY
uniprot id: A0A286ZYT0
uniprot id: A0A287BLC1
uniprot id: A0A4X1T3Z3
uniprot id: A0A4X1T4P6
uniprot id: A0A8D0SFP1
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9823:NKX2-5
gene id: 9823:NKX2-5
uniprot id: A0A287AD23
uniprot id: A0A4X1UCP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

9823:CHAT
gene id: 9823:CHAT
uniprot id: P13222
names: Function
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

9823:DKK3
gene id: 9823:DKK3
uniprot id: A0A4X1TS89
uniprot id: Q2HWR5
names: Similarity
messages: Belongs to the dickkopf family.

9823:LOC100520753
gene id: 9823:LOC100520753
uniprot id: K9J6L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9823:FASLG
gene id: 9823:FASLG
uniprot id: Q9BEA8
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: By IL-18.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:11429161, PubMed:12371937). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:11429161, PubMed:12371937). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarity).
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Homotrimer. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.
messages: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.
messages: Lysosome lumen
messages: Monoubiquitinated.
messages: N-glycosylated. Glycosylation enhances apoptotic activity.
messages: Nucleus
messages: Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.

9823:FBXO9
gene id: 9823:FBXO9
uniprot id: A0A4X1TFG6
uniprot id: F1S7C6
names: Subcellular Location Annotation
messages: Cytoplasm

9823:HKDC1
gene id: 9823:HKDC1
uniprot id: A0A286ZQ27
uniprot id: A0A4X1TKL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9823:MED7
gene id: 9823:MED7
uniprot id: A0A480SYR1
uniprot id: Q2F7Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

9823:TMEM59
gene id: 9823:TMEM59
uniprot id: A0A287A223
uniprot id: A0A480WJN6
uniprot id: A0A8D0JZY9
uniprot id: A0A8D0K160
uniprot id: A0A8D1E1V2
uniprot id: Q2F7Z7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
messages: Belongs to the TMEM59 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Interacts with ATG16L1 (via WD repeats).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: N-glycosylated.
messages: The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.

9823:OLFML2B
gene id: 9823:OLFML2B
uniprot id: A0A287B7K8
uniprot id: A0A8D0UDB4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:TSPAN4
gene id: 9823:TSPAN4
uniprot id: A0A4X1VZD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9823:GSS
gene id: 9823:GSS
uniprot id: A0A8D1TEU2
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9823:DPP4
gene id: 9823:DPP4
uniprot id: A0A480UDQ9
uniprot id: P22411
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:14719797). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity).
messages: Inhibited by GPC3 and diprotin A.
messages: Membrane raft
messages: Monomer. Homodimer (PubMed:12690074). Heterodimer with Seprase (FAP) (By similarity). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation (By similarity). Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (By similarity). Associates with collagen (By similarity). Interacts with PTPRC; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (By similarity). Interacts (via extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity (By similarity). Interacts with CAV1 (via the N-terminus); the interaction is direct (By similarity). Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11 (By similarity). Interacts with IGF2R; the interaction is direct (By similarity). Interacts with GPC3 (By similarity).
messages: N- and O-Glycosylated.
messages: Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation (By similarity).
messages: Secreted
messages: The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
messages: invadopodium membrane
messages: lamellipodium membrane

9823:SEPT12
gene id: 9823:SEPT12
uniprot id: A0A4X1VLP5
uniprot id: F1RK75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9823:VPS33A
gene id: 9823:VPS33A
uniprot id: A0A4X1U903
uniprot id: A5A780
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9823:TFF2
gene id: 9823:TFF2
uniprot id: A0A4X1TI83
uniprot id: I3LMK2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:PPP1R14C
gene id: 9823:PPP1R14C
uniprot id: A0A4X1VL95
uniprot id: A0A5G2RL03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Inhibitor of PPP1CA.
messages: Membrane

9823:GUSB
gene id: 9823:GUSB
uniprot id: Q4FAT7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

9823:SLC35B4
gene id: 9823:SLC35B4
uniprot id: A0A8D1SHV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9823:GPATCH11
gene id: 9823:GPATCH11
uniprot id: A0A4X1T1R0
uniprot id: A0A5G2QRJ3
names: Similarity
messages: Belongs to the GPATCH11 family.

9823:ACADVL
gene id: 9823:ACADVL
uniprot id: A0A480K129
uniprot id: A0A4X1V0U7
uniprot id: A0A8D0SMK4
uniprot id: F1ST43
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9823:SYT17
gene id: 9823:SYT17
uniprot id: A0A287B306
uniprot id: A0A4X1VNJ6
uniprot id: I3L5Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9823:SMG9
gene id: 9823:SMG9
uniprot id: A0A8D1RV96
uniprot id: F1RMV1
names: Similarity
messages: Belongs to the SMG9 family.

9823:LOC100524789
gene id: 9823:LOC100524789
uniprot id: A0A8D0Z750
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:SLC28A1
gene id: 9823:SLC28A1
uniprot id: O62667
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Cell membrane
messages: Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs.

9823:THBS2
gene id: 9823:THBS2
uniprot id: A0A480QMZ4
uniprot id: A0A4X1VX85
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:BAZ1A
gene id: 9823:BAZ1A
uniprot id: A0A4X1T7N5
uniprot id: F1SHI5
names: Subcellular Location Annotation
messages: Nucleus

9823:B3GAT2
gene id: 9823:B3GAT2
uniprot id: A0A8D1YBK7
uniprot id: I3LR31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:GTF2H5
gene id: 9823:GTF2H5
uniprot id: A0A4X1VPK7
uniprot id: F2Z5A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9823:PKN1
gene id: 9823:PKN1
uniprot id: A0A287BRF6
uniprot id: A0A4X1V4I5
uniprot id: A0A4X1V693
uniprot id: F1SCG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9823:ENSA
gene id: 9823:ENSA
uniprot id: P68211
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Interacts (when phosphorylated at Ser-67) with PPP2R2D. Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109 (By similarity).
messages: Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA (By similarity).
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity).
messages: The N-terminus is blocked.

9823:SGSM1
gene id: 9823:SGSM1
uniprot id: A0A287B2S2
uniprot id: A0A287BIP3
uniprot id: A0A8D0N4E2
uniprot id: A0A8D0WR47
names: Similarity
messages: Belongs to the RUTBC family.

9823:CYP3A46
gene id: 9823:CYP3A46
uniprot id: A7KZR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9823:GORASP1
gene id: 9823:GORASP1
uniprot id: A0A4X1TUQ3
names: Similarity
messages: Belongs to the GORASP family.

9823:PPAT
gene id: 9823:PPAT
uniprot id: A0A4X1TU40
uniprot id: F1RTV1
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9823:FMO3
gene id: 9823:FMO3
uniprot id: A0A4X1V7C5
uniprot id: I3LS94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Microsome membrane

9823:TEKT1
gene id: 9823:TEKT1
uniprot id: A0A8D1EF23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9823:SLC26A11
gene id: 9823:SLC26A11
uniprot id: B6EAV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane

9823:TERF2IP
gene id: 9823:TERF2IP
uniprot id: A0A8D0PU77
uniprot id: F1S459
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9823:MTMR8
gene id: 9823:MTMR8
uniprot id: A0A286ZZ52
uniprot id: A0A8D0UQ79
uniprot id: A0A8D1ZP82
uniprot id: I3LJL9
uniprot id: I3LK82
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9823:ZNF202
gene id: 9823:ZNF202
uniprot id: A0A4X1VHT3
uniprot id: I3LE10
names: Subcellular Location Annotation
messages: Nucleus

9823:PI4KB
gene id: 9823:PI4KB
uniprot id: A0A4X1W0B2
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9823:CDC42EP1
gene id: 9823:CDC42EP1
uniprot id: A0A480P3R5
uniprot id: A0A4X1UTJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9823:TNFSF13
gene id: 9823:TNFSF13
uniprot id: A0A4X1V4X0
uniprot id: A9Q6C0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:GYS2
gene id: 9823:GYS2
uniprot id: E0X6R4
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9823:LOC100513346
gene id: 9823:LOC100513346
uniprot id: A0A4X1VS99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle
messages: cytosol
messages: trans-Golgi network

9823:STEAP3
gene id: 9823:STEAP3
uniprot id: A0A286ZKM1
uniprot id: A0A287AW93
uniprot id: A0A4X1SMD0
uniprot id: A0A4X1SNA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9823:LOC100511653
gene id: 9823:LOC100511653
uniprot id: A0A4X1UNL0
uniprot id: A0A5G2QNV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CFTR
gene id: 9823:CFTR
uniprot id: Q6PQZ2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer (PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).
messages: N-glycosylated.
messages: Nucleus
messages: Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.
messages: Recycling endosome membrane
messages: The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.
messages: The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.
messages: Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity).

9823:FAM46D
gene id: 9823:FAM46D
uniprot id: A0A4X1W2X7
uniprot id: F1S1S5
names: Similarity
messages: Belongs to the TENT family.

9823:IGF2
gene id: 9823:IGF2
uniprot id: G9BFT5
uniprot id: P23695
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Interacts with MYORG; this interaction is required for IGF2 secretion. Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.
messages: Secreted
messages: The IGF2 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is imprinted, hence silenced.
messages: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).
messages: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate.

9823:SEC24A
gene id: 9823:SEC24A
uniprot id: A0A287AWQ7
uniprot id: A0A4X1UXF5
uniprot id: A0A4X1V002
uniprot id: A0A4X1V021
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9823:TAMM41
gene id: 9823:TAMM41
uniprot id: A0A480MCC2
uniprot id: A0A4X1UGZ8
uniprot id: A0A8D0QDG4
uniprot id: F1SQA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9823:NAIF1
gene id: 9823:NAIF1
uniprot id: A0A8D0PD34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

9823:TMEM91
gene id: 9823:TMEM91
uniprot id: A0A8D0LMB5
uniprot id: A0A8D0R4T0
uniprot id: F1RH85
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:NAAA
gene id: 9823:NAAA
uniprot id: A0A8D1BMU0
uniprot id: F1RYU7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9823:PPP1R3B
gene id: 9823:PPP1R3B
uniprot id: A0A5G2QRJ8
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9823:DDX21
gene id: 9823:DDX21
uniprot id: A0A8D1LWS8
uniprot id: F1SUG7
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9823:GABRA1
gene id: 9823:GABRA1
uniprot id: A0A480NP21
uniprot id: A0A4X1U2W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:AZIN2
gene id: 9823:AZIN2
uniprot id: A0A8D1VWG4
uniprot id: B2CRH7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9823:PPIF
gene id: 9823:PPIF
uniprot id: A0A287AP21
uniprot id: A0A4X1SIE5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9823:LOC100737983
gene id: 9823:LOC100737983
uniprot id: A0A4X1W7L0
uniprot id: F1SFB2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FAM3A
gene id: 9823:FAM3A
uniprot id: A0A8D1F0E2
uniprot id: A0A8D1F4G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9823:FXYD6
gene id: 9823:FXYD6
uniprot id: A0A4X1SVR1
names: Similarity
messages: Belongs to the FXYD family.

9823:MAPK8
gene id: 9823:MAPK8
uniprot id: A0A480EHQ8
uniprot id: A0A4X1VFI4
uniprot id: A0A5G2Q9X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9823:C4H8orf37
gene id: 9823:C4H8orf37
uniprot id: A0A287BAN6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9823:DICER1
gene id: 9823:DICER1
uniprot id: E2JE26
names: Function
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

9823:ATP5O
gene id: 9823:ATP5O
uniprot id: Q2EN81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

9823:DBX1
gene id: 9823:DBX1
uniprot id: A0A8D0T972
uniprot id: F1SFY4
names: Subcellular Location Annotation
messages: Nucleus

9823:RIPK3
gene id: 9823:RIPK3
uniprot id: F1SGQ6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9823:SERPINA6
gene id: 9823:SERPINA6
uniprot id: A0A8D0PK69
uniprot id: F1SCF1
uniprot id: Q9GK37
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
messages: Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids (By similarity).
messages: Secreted

9823:GLIPR1
gene id: 9823:GLIPR1
uniprot id: F1SGE0
names: Similarity
messages: Belongs to the CRISP family.

9823:VSTM5
gene id: 9823:VSTM5
uniprot id: A0A4X1TYN1
uniprot id: F1STK6
names: Subcellular Location Annotation
messages: Membrane

9823:VARS
gene id: 9823:VARS
uniprot id: A0A8D1SAD4
uniprot id: B9TSR5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9823:LOC100157935
gene id: 9823:LOC100157935
uniprot id: A0A4X1SL06
uniprot id: F1SD52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9823:SPNS3
gene id: 9823:SPNS3
uniprot id: A0A4X1UMA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9823:SAA3
gene id: 9823:SAA3
uniprot id: Q2HXZ9
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9823:ING3
gene id: 9823:ING3
uniprot id: A0A287A6F4
uniprot id: A0A4X1W373
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9823:OTUB1
gene id: 9823:OTUB1
uniprot id: A0A4X1VGV7
uniprot id: C5H0C6
names: Similarity
messages: Belongs to the peptidase C65 family.

9823:F2
gene id: 9823:F2
uniprot id: Q19AZ8
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5. In plasma, interacts (via N-terminus) with alpha-1-microglobulin; this interaction does not prevent the activation of prothrombin to thrombin.
messages: Inhibited by SERPINA5.
messages: Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin (By similarity).
messages: The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin (By similarity).
messages: Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).

9823:ATP2C1
gene id: 9823:ATP2C1
uniprot id: A0A4X1V4J2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

9823:MUL1
gene id: 9823:MUL1
uniprot id: A0A4X1W528
names: Subcellular Location Annotation
messages: Membrane

9823:TMED6
gene id: 9823:TMED6
uniprot id: A0A4X1SF79
uniprot id: F1S389
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:HDDC2
gene id: 9823:HDDC2
uniprot id: A0A8D1RTL1
uniprot id: F1S2V3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

9823:MEOX1
gene id: 9823:MEOX1
uniprot id: A0A8D1RSY1
uniprot id: A0A8D2CGI1
uniprot id: F1S1H4
names: Subcellular Location Annotation
messages: Nucleus

9823:CFAP126
gene id: 9823:CFAP126
uniprot id: A0A480EN68
uniprot id: A0A8D1L7G5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9823:SEC61B
gene id: 9823:SEC61B
uniprot id: A0A287BMU4
uniprot id: A0A4X1SH59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9823:SYP
gene id: 9823:SYP
uniprot id: A0A480MAK8
uniprot id: A0A4X1SYD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane
messages: synaptosome

9823:EBP
gene id: 9823:EBP
uniprot id: A0A4X1VJ04
uniprot id: D0G6S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:KIAA0907
gene id: 9823:KIAA0907
uniprot id: A0A480JWI4
uniprot id: A0A4X1VU75
names: Similarity
messages: Belongs to the KHDC4 family.

9823:PARP3
gene id: 9823:PARP3
uniprot id: A0A8D1BNC0
uniprot id: I3LJ55
uniprot id: I3LTD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9823:CHUK
gene id: 9823:CHUK
uniprot id: A0A4X1U511
uniprot id: B0LXP6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9823:GYS1
gene id: 9823:GYS1
uniprot id: E0X6R2
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9823:MS4A2
gene id: 9823:MS4A2
uniprot id: A0A8D1IHT8
uniprot id: Q8MJ38
names: Similarity
messages: Belongs to the MS4A family.

9823:PPP2R5D
gene id: 9823:PPP2R5D
uniprot id: A0A4X1SEK7
uniprot id: A5GFQ9
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9823:CAPZA1
gene id: 9823:CAPZA1
uniprot id: A0A4X1T8I3
uniprot id: A0PFK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9823:WDR55
gene id: 9823:WDR55
uniprot id: A0A8D1D656
uniprot id: F1RGE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9823:TMEM251
gene id: 9823:TMEM251
uniprot id: Q6QA74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LYSET family.
messages: Golgi apparatus membrane
messages: Interacts with GNPTAB; this interaction is important for proper localization of GNPTAB in Golgi stacks. Interacts with MBTPS1.
messages: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases.

9823:VEGFA
gene id: 9823:VEGFA
uniprot id: A0A4X1V7P2
uniprot id: A0A5G2R854
uniprot id: P49151
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (By similarity). Interacts with BSG (By similarity).
messages: Secreted

9823:SLC25A3
gene id: 9823:SLC25A3
uniprot id: A0A4X1SQC1
uniprot id: C8C420
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9823:ETV4
gene id: 9823:ETV4
uniprot id: A0A480JQF4
uniprot id: A0A480XKI0
uniprot id: A0A4X1TNR5
uniprot id: A0A8D1ZUH6
uniprot id: F1S1H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9823:SIRT3
gene id: 9823:SIRT3
uniprot id: A0A8D1CYA5
uniprot id: A0A8D1P6H0
uniprot id: A8CYZ2
uniprot id: B7U9B0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

9823:PIGF
gene id: 9823:PIGF
uniprot id: A0A4X1SH27
uniprot id: F1S5M1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:FAM19A4
gene id: 9823:FAM19A4
uniprot id: A0A287B8Y1
uniprot id: A0A4X1VCI7
names: Similarity
messages: Belongs to the TAFA family.

9823:SSR1
gene id: 9823:SSR1
uniprot id: A0A480W9A0
uniprot id: A0A8D1FWK9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9823:SELENOK
gene id: 9823:SELENOK
uniprot id: Q2EN82
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenoprotein K family.
messages: Cell membrane
messages: Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity (By similarity).
messages: Endoplasmic reticulum membrane
messages: Interacts with DERL1, DERL2, DERL3 and SELENOS. The SELENOK-SELENOS complex interacts with VCP. Interacts with ZDHHC6.
messages: Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).
messages: Truncated SELENOK proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) complex, which recognizes the diglycine (Gly-Gly) at the C-terminus of truncated SELENOK proteins.

9823:IER5L
gene id: 9823:IER5L
uniprot id: A0A4X1TIH1
names: Similarity
messages: Belongs to the IER family.

9823:S100A11
gene id: 9823:S100A11
uniprot id: P31950
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.
messages: Cytoplasm
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.
messages: Nucleus
messages: Phosphorylation at Thr-8 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.

9823:LOC100519082
gene id: 9823:LOC100519082
uniprot id: A0A5G2QWL4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9823:GPR182
gene id: 9823:GPR182
uniprot id: A0A287ARV3
uniprot id: A0A4X1W8F6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:ATAT1
gene id: 9823:ATAT1
uniprot id: A0A4X1VE66
uniprot id: A0A4X1VJE9
uniprot id: A0A5G2R9W6
uniprot id: A0A8D0IG44
uniprot id: I3L925
uniprot id: Q767K7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

9823:CACNA2D1
gene id: 9823:CACNA2D1
uniprot id: A0A287AP40
uniprot id: A0A480T791
uniprot id: A0A4X1SKZ9
uniprot id: A0A4X1SL12
uniprot id: A0A8D0IYJ4
uniprot id: A0A8D0J0B3
uniprot id: A0A8D0ZLH1
uniprot id: O77773
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9823:ATP6V1F
gene id: 9823:ATP6V1F
uniprot id: A0A8D1H0W9
uniprot id: F1SMN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9823:CITED1
gene id: 9823:CITED1
uniprot id: A0A287ALJ7
uniprot id: A0A287B8H9
uniprot id: A0A4X1VW13
uniprot id: A0A4X1W323
uniprot id: A0A8D1CUE4
uniprot id: Q2VIU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9823:TMEM59L
gene id: 9823:TMEM59L
uniprot id: A0A4X1U390
uniprot id: F1S907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9823:AQP7
gene id: 9823:AQP7
uniprot id: A0A4X1UQS3
uniprot id: A0A4X1URD6
uniprot id: A9Y007
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9823:ACY1
gene id: 9823:ACY1
uniprot id: A0A480XYA6
uniprot id: P37111
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-acetylated amino acids to acetate and free amino acids.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with SPHK1 (By similarity).

9823:IGFBP1
gene id: 9823:IGFBP1
uniprot id: A0A4X1UAL4
uniprot id: E0A8P1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9823:IGF2BP2
gene id: 9823:IGF2BP2
uniprot id: A0A4X1UIF2
uniprot id: F1SFK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9823:ATP6V0D2
gene id: 9823:ATP6V0D2
uniprot id: A0A4X1UE85
uniprot id: F1RXD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9823:SCG5
gene id: 9823:SCG5
uniprot id: A0A8D1I734
uniprot id: A7YB33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9823:PCMTD1
gene id: 9823:PCMTD1
uniprot id: A0A287BAK7
uniprot id: A0A4X1THL2
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9823:NIPAL1
gene id: 9823:NIPAL1
uniprot id: A0A287AD64
uniprot id: A0A4X1UI07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9823:AGTR1
gene id: 9823:AGTR1
uniprot id: P30555
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: C-terminal Ser or Thr residues may be phosphorylated.
messages: Cell membrane
messages: Interacts with MAS1 (By similarity). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:8491254). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (By similarity).

9823:PSMB5
gene id: 9823:PSMB5
uniprot id: A0A480WQB6
uniprot id: A0A4X1V3T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9823:PFDN2
gene id: 9823:PFDN2
uniprot id: A0A4X1VSI5
uniprot id: F1S192
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9823:LOC100156674
gene id: 9823:LOC100156674
uniprot id: A0A8D1JBR2
names: Subcellular Location Annotation
messages: Membrane

9823:MCHR2
gene id: 9823:MCHR2
uniprot id: A0A8D1VDP7
uniprot id: Q2UV90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:STAR
gene id: 9823:STAR
uniprot id: A0A4X1VUU5
uniprot id: Q5Q0U1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9823:CENPQ
gene id: 9823:CENPQ
uniprot id: A0A8D0I8X6
uniprot id: F1RQ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9823:MED27
gene id: 9823:MED27
uniprot id: Q6Q7J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
messages: Nucleus

9823:CMPK1
gene id: 9823:CMPK1
uniprot id: A0A4X1WAJ2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9823:RBM42
gene id: 9823:RBM42
uniprot id: A0A286ZXI3
uniprot id: A0A4X1TII9
uniprot id: A0A8D1WAD4
uniprot id: F1RM56
names: Similarity
messages: Belongs to the RRM RBM42 family.

9823:OTULIN
gene id: 9823:OTULIN
uniprot id: A0A4X1TR93
uniprot id: A0A5G2QLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9823:GUCY1B3
gene id: 9823:GUCY1B3
uniprot id: Q4ZHR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9823:CFI
gene id: 9823:CFI
uniprot id: A0A287AQ20
uniprot id: A0A8D0K381
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:RBPJ
gene id: 9823:RBPJ
uniprot id: A0A287A324
uniprot id: A0A287A3B7
uniprot id: A0A4X1V8S0
uniprot id: A0A4X1V9N0
uniprot id: A0A4X1VAW4
uniprot id: A0A4X1VAZ3
uniprot id: K9J4T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9823:GPR119
gene id: 9823:GPR119
uniprot id: A0A4X1W3U5
uniprot id: F1RTG3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9823:CTSB
gene id: 9823:CTSB
uniprot id: A0A480YY66
uniprot id: A1E295
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Directly interacts with SHKBP1.
messages: Expressed in heart (at protein level).
messages: Lysosome
messages: Melanosome
messages: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).
messages: extracellular space

9823:APP
gene id: 9823:APP
uniprot id: A0A286ZTE6
uniprot id: A0A480E073
uniprot id: A0A4X1UC79
uniprot id: A0A4X1UE02
uniprot id: A0A4X1UF49
uniprot id: A0A8D1XLW3
uniprot id: P79307
uniprot id: Q2XQ99
uniprot id: Q2XQA0
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Amyloid-beta peptides are degraded by IDE.
messages: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron (By similarity).
messages: Belongs to the APP family.
messages: Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1 and NUMB and DAB1 (By similarity). Binding to DAB1 inhibits its serine phosphorylation (By similarity). Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Also interacts with GPCR-like protein BPP, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts, through a C-terminal domain, with GNAO1. Amyloid-beta protein 42 binds CHRNA7 in hippocampal neurons (By similarity). Amyloid-beta associates with HADH2 (By similarity). Interacts with CPEB1, ANKS1B, TNFRSF21 and AGER (By similarity). Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; dimerization is enhanced in the presence of Cu(2+) ions. Can form homodimers; this is promoted by heparin binding (By similarity). Amyloid-beta protein 40 interacts with S100A9 (By similarity). CTF-alpha product of APP interacts with GSAP (By similarity). Interacts with SORL1 (via N-terminal ectodomain); this interaction retains APP in the trans-Golgi network and reduces processing into soluble APP-alpha and amyloid-beta peptides (By similarity). The C99 fragment also interacts with SORL1 (By similarity). Interacts with PLD3 (By similarity). Interacts with VDAC1 (By similarity). Interacts with NSG1; could regulate APP processing (By similarity). Amyloid-beta protein 42 interacts with FPR2 (By similarity). Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity). Interacts with LRRK2 (By similarity). Interacts (via cytoplasmic domain) with KIF5B (By similarity). Interacts (via C-terminus) with APBB2/FE65L1 (via C-terminus) (By similarity). Interacts (via intracell…
messages: Cell membrane
messages: Cell surface
messages: Chelation of metal ions, notably copper, iron and zinc, can induce histidine-bridging between amyloid-beta molecules resulting in amyloid-beta-metal aggregates. Extracellular zinc-binding increases binding of heparin to APP and inhibits collagen-binding.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Extracellular binding and reduction of copper, results in a corresponding oxidation of Cys-144 and Cys-158, and the formation of a disulfide bond.
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity). Inhibits G(o)-alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N- and O-glycosylated.
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific. Phosphorylation can affect APP processing, neuronal differentiation and interaction with other proteins. Phosphorylated on Thr-743 in neuronal cells by Cdc5 kinase and Mapk10, in dividing cells by Cdc2 kinase in a cell-cycle dependent manner with maximal levels at the G2/M phase and, in vitro, by GSK-3-beta. The Thr-743 phosphorylated form causes a conformational change which reduces binding of Fe65 family members. In dopaminergic (DA) neurons, phosphorylation on Thr-743 by LRKK2 promotes the production and the nuclear translocation of the APP intracellular domain (AICD) which induces DA neuron apoptosis. Phosphorylation on Tyr-757 is required for SHC binding. Phosphorylated in the extracellular domain by casein kinases on both soluble and membrane-bound APP. This phosphorylation is inhibited by heparin.
messages: Proteolytically cleaved by caspases during neuronal apoptosis. Cleavage at Asp-739 by either caspase-3, -8 or -9 results in the production of the neurotoxic C31 peptide and the increased production of amyloid-beta peptides.
messages: Proteolytically processed under normal cellular conditions. Cleavage either by alpha-secretase, beta-secretase or theta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, and the retention of corresponding membrane-anchored C-terminal fragments, C80, C83 and C99. Subsequent processing of C80 and C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is non-amyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid-beta proteins, amyloid-beta protein 40 and amyloid-beta protein 42, major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59). PSEN1 cleavage is more efficient with C83 than with C99 as substrate (in vitro). Amyloid-beta protein 40 and Amyloid-beta protein 42 are cleaved by ACE. Many other minor amyloid-beta peptides, amyloid-beta 1-X peptides, are found in cerebral spinal fluid (CSF) including the amyloid-beta X-15 peptides, produced from the cleavage by alpha-secretase.
messages: Secreted
messages: Sulfated on tyrosine residues.
messages: The C-terminal region can bind zinc ions; this favors dimerization and formation of higher oligomers.
messages: The GFLD subdomain binds Cu(2+) ions; this promotes homodimerization.
messages: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The PID domain-containing proteins which bind APP require the YENPTY motif for full interaction. These interactions are independent of phosphorylation on the terminal tyrosine residue. The YENPXY site is also involved in clathrin-mediated endocytosis.
messages: The OX-2 motif shows some similarity to a region in the N-terminus of CD200/MOX2.
messages: The basolateral sorting signal (BaSS) is required for sorting of membrane proteins to the basolateral surface of epithelial cells.
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: The transmembrane helix undergoes a conformation change and unravels partially when bound to PSEN1, facilitating cleavage by PSEN1.
messages: Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP).
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9823:CENPH
gene id: 9823:CENPH
uniprot id: A0A4X1UK66
uniprot id: I3LPJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9823:ATP5D
gene id: 9823:ATP5D
uniprot id: A0A286ZYL7
uniprot id: A0A4X1VPE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

9823:C5H12orf10
gene id: 9823:C5H12orf10
uniprot id: A0A8D1Y7E6
uniprot id: F1SFR1
names: Similarity
messages: Belongs to the MYG1 family.

9823:FA2H
gene id: 9823:FA2H
uniprot id: A0A480VWF2
uniprot id: A0A4X1SSW8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:INMT
gene id: 9823:INMT
uniprot id: A0A480ZLY1
uniprot id: A0A4X1SZZ4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9823:COQ2
gene id: 9823:COQ2
uniprot id: A0A287B031
uniprot id: A0A4X1TL08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

9823:HOXB2
gene id: 9823:HOXB2
uniprot id: A0A8D0ZNI3
uniprot id: F1RWG7
names: Subcellular Location Annotation
messages: Nucleus

9823:RPS16
gene id: 9823:RPS16
uniprot id: B6V8C7
uniprot id: Q29201
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9823:SHOX2
gene id: 9823:SHOX2
uniprot id: A0A4X1SHY9
uniprot id: A0A8D0PD01
uniprot id: I3L828
names: Subcellular Location Annotation
messages: Nucleus

9823:CCRL2
gene id: 9823:CCRL2
uniprot id: Q75ZH0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
messages: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity).

9823:LOC100152714
gene id: 9823:LOC100152714
uniprot id: A0A4X1UGB0
uniprot id: F1RXC0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9823:TRMT6
gene id: 9823:TRMT6
uniprot id: A0A480WZS9
uniprot id: A0A8D0UXI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9823:LOC106505477
gene id: 9823:LOC106505477
uniprot id: A0A5G2QIQ5
uniprot id: A0A8D1CSU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CLCN2
gene id: 9823:CLCN2
uniprot id: A0A480UNX6
uniprot id: A0A8D1E7M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

9823:KRT20
gene id: 9823:KRT20
uniprot id: A0A4X1UC07
uniprot id: F1RXG4
names: Similarity
messages: Belongs to the intermediate filament family.

9823:NUDT7
gene id: 9823:NUDT7
uniprot id: A0A5G2QLN6
uniprot id: A0A8D1UEH6
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9823:NR5A1
gene id: 9823:NR5A1
uniprot id: P79387
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation stimulates the transcriptional activity.
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with NR0B2, NCOA2 and PPARGC1A. Interacts with DGKQ and CDK7. Binds to and activated by HIPK3 (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity).
messages: Sumoylation reduces CDK7-mediated phosphorylation on Ser-203.
messages: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity).

9823:LOC100737844
gene id: 9823:LOC100737844
uniprot id: A0A8D1YWD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:LAMTOR5
gene id: 9823:LAMTOR5
uniprot id: Q66X52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.
messages: Belongs to the LAMTOR5 family.
messages: Homodimer. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1.
messages: Lysosome
messages: cytosol

9823:PSMD4
gene id: 9823:PSMD4
uniprot id: A0A288CG47
uniprot id: A0A4X1W0B7
uniprot id: A0A8D1Q155
uniprot id: Q32YV9
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9823:POMGNT2
gene id: 9823:POMGNT2
uniprot id: A0A4X1TGU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:LMCD1
gene id: 9823:LMCD1
uniprot id: Q5PXT2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Highly expressed in both skeletal muscle and cardiac muscle.
messages: Interacts with beta-dystroglycan. Interacts with GATA1, GATA4 and GATA6 (By similarity).
messages: Nucleus
messages: The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6.
messages: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway (By similarity).

9823:SFR1
gene id: 9823:SFR1
uniprot id: A0A4X1TNL3
uniprot id: F1S5P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9823:IL17A
gene id: 9823:IL17A
uniprot id: Q60I29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IL-17 family.
messages: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance. Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation. Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis. As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutroph…
messages: Highly expressed in adult heart, skin, and intestinal tissues, such as jejunum and ileum.
messages: Homodimer. Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule. IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex. IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer. Heterodimer with IL17F. IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer. IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes.
messages: Secreted

9823:USE1
gene id: 9823:USE1
uniprot id: A0A4X1UGC1
uniprot id: F1S960
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:OXR1
gene id: 9823:OXR1
uniprot id: A0A287A1K0
uniprot id: A0A287AV42
uniprot id: A0A480JWV7
uniprot id: A0A8D1RS59
uniprot id: A0A8D1RSX4
uniprot id: A0A8D1UA10
names: Similarity
messages: Belongs to the OXR1 family.

9823:LOC100525298
gene id: 9823:LOC100525298
uniprot id: A0A4X1VDK4
uniprot id: F1S9N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CSRNP1
gene id: 9823:CSRNP1
uniprot id: A0A8D2AC51
uniprot id: F1SJR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9823:IRF9
gene id: 9823:IRF9
uniprot id: Q0GFA1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:NT5C3A
gene id: 9823:NT5C3A
uniprot id: A0A287A1I0
uniprot id: A0A287BPC7
uniprot id: A0A4X1SP24
uniprot id: A0A4X1SQB0
uniprot id: A0A8D1FDL2
uniprot id: I3LCJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9823:LOC100623441
gene id: 9823:LOC100623441
uniprot id: A0A8D1PZR9
uniprot id: I3LC84
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:MSL3
gene id: 9823:MSL3
uniprot id: A0A480TMJ2
uniprot id: A0A8D0XSY0
uniprot id: A0A8D1CJF7
uniprot id: K7GS61
names: Subcellular Location Annotation
messages: Nucleus

9823:ATP6AP2
gene id: 9823:ATP6AP2
uniprot id: A0A287AJK1
uniprot id: A0A8D1Y888
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9823:LOC100156107
gene id: 9823:LOC100156107
uniprot id: A0A286ZM51
uniprot id: A0A4X1UYM7
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9823:SLC35E4
gene id: 9823:SLC35E4
uniprot id: A0A4X1VA66
uniprot id: F1RPE3
names: Subcellular Location Annotation
messages: Membrane

9823:TTC26
gene id: 9823:TTC26
uniprot id: A0A287ARA1
uniprot id: A0A287BF54
uniprot id: A0A8D0ZYC3
uniprot id: A0A8D2C6B2
names: Similarity
messages: Belongs to the IFT56 family.

9823:HSP90B1
gene id: 9823:HSP90B1
uniprot id: A0A4X1T658
uniprot id: Q29092
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Endoplasmic reticulum lumen
messages: Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9 (By similarity). Interacts with CNPY3; this interaction is disrupted in the presence of ATP. Interacts with several TLRs, including TLR4 and TLR9, but not with TLR3 (By similarity). Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23 (By similarity). Interacts with IL1B; the interaction facilitates cargo translocation into the ERGIC (By similarity).
messages: Melanosome
messages: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity).
messages: Phosphorylated.
messages: Sarcoplasmic reticulum lumen

9823:IFN-ALPHA-8
gene id: 9823:IFN-ALPHA-8
uniprot id: A0A8D0SHB6
uniprot id: Q0GC46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9823:LOC100517331
gene id: 9823:LOC100517331
uniprot id: F1S6M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:FGF1
gene id: 9823:FGF1
uniprot id: A0A4X1STD1
uniprot id: F1RM38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9823:FAM46C
gene id: 9823:FAM46C
uniprot id: A0A076V3E9
uniprot id: A0A287AN43
uniprot id: A0A4X1STW6
names: Similarity
messages: Belongs to the TENT family.

9823:SLC30A5
gene id: 9823:SLC30A5
uniprot id: B6ECZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9823:RAB27B
gene id: 9823:RAB27B
uniprot id: A0A4X1UFY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9823:CCDC126
gene id: 9823:CCDC126
uniprot id: A0A286ZZT8
uniprot id: A0A4X1T3R3
names: Subcellular Location Annotation
messages: Secreted

9823:CTSK
gene id: 9823:CTSK
uniprot id: Q9GLE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Expressed in the thyroid epithelial cells.
messages: Lysosome
messages: Secreted
messages: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

9823:CASQ1
gene id: 9823:CASQ1
uniprot id: A0A4X1VUN1
uniprot id: F1RJW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9823:SSU72
gene id: 9823:SSU72
uniprot id: A0A4X1W394
uniprot id: F1RJC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9823:SMIM15
gene id: 9823:SMIM15
uniprot id: A0A287BL25
uniprot id: A0A4X1UVU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9823:PDX1
gene id: 9823:PDX1
uniprot id: A0A287B9A1
uniprot id: A0A4X1TIC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9823:CCNT1
gene id: 9823:CCNT1
uniprot id: A0A8D0II06
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

9823:EIF3I
gene id: 9823:EIF3I
uniprot id: A0A480TXZ6
uniprot id: A0A4X1VY66
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9823:RAB33B
gene id: 9823:RAB33B
uniprot id: A0A4X1VH23
uniprot id: I3LK86
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9823:KDELR1
gene id: 9823:KDELR1
uniprot id: A0A4X1W1X6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9823:FAM3C
gene id: 9823:FAM3C
uniprot id: A0A480TAV6
uniprot id: A0A8D0I7J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9823:EIF4A2
gene id: 9823:EIF4A2
uniprot id: A0A4X1UDW6
uniprot id: A6M930
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9823:SLC46A2
gene id: 9823:SLC46A2
uniprot id: A0A8D0TY53
uniprot id: F1SNA4
names: Subcellular Location Annotation
messages: Membrane

9823:RCE1
gene id: 9823:RCE1
uniprot id: A0A287A799
uniprot id: A0A4X1TD43
uniprot id: A0A4X1TD88
uniprot id: A0A8D1YL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:SF3A3
gene id: 9823:SF3A3
uniprot id: A0A4X1VWI8
uniprot id: F1SV40
names: Similarity
messages: Belongs to the SF3A3 family.

9823:SULT1E1
gene id: 9823:SULT1E1
uniprot id: Q95MF8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9823:WDR46
gene id: 9823:WDR46
uniprot id: A0A287BMA8
uniprot id: A0A8D0JDR8
names: Subcellular Location Annotation
messages: nucleolus

9823:FAM161A
gene id: 9823:FAM161A
uniprot id: A0A287B6Q9
uniprot id: A0A4X1WBM4
uniprot id: A0A8D1IQN2
names: Similarity
messages: Belongs to the FAM161 family.

9823:SOX3
gene id: 9823:SOX3
uniprot id: A0A8D0VFP9
uniprot id: I3LG51
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100154128
gene id: 9823:LOC100154128
uniprot id: F1SAC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:NR2C1
gene id: 9823:NR2C1
uniprot id: A0A8D0QAH0
uniprot id: A0A8D1T6A0
uniprot id: F1SQP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9823:PADI1
gene id: 9823:PADI1
uniprot id: A0A8D1CS67
uniprot id: K7GNB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9823:SPPL2C
gene id: 9823:SPPL2C
uniprot id: F1RRS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9823:FXR1
gene id: 9823:FXR1
uniprot id: A0A480PRJ6
uniprot id: A0A480SQ27
uniprot id: A0A4X1V102
uniprot id: A0A4X1V2E1
names: Similarity
messages: Belongs to the FMR1 family.

9823:TACR2
gene id: 9823:TACR2
uniprot id: A0A4X1TFX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:LOC100156932
gene id: 9823:LOC100156932
uniprot id: A0A480K1G1
uniprot id: A0A4X1VJL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9823:LOC100519511
gene id: 9823:LOC100519511
uniprot id: A0A5G2R7E2
uniprot id: A0A8D1K596
names: Similarity
messages: Belongs to the CFAP97 family.

9823:KCNE4
gene id: 9823:KCNE4
uniprot id: A0A286ZPX1
uniprot id: A0A4X1UBB8
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9823:DCTPP1
gene id: 9823:DCTPP1
uniprot id: A0A8D1HZY4
uniprot id: F1RG63
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9823:PLAU
gene id: 9823:PLAU
uniprot id: P04185
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Forms heterodimer with SERPINA5. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR. In complex with SERPINE1, interacts with PLAUR/uPAR. Interacts with SORL1 and LRP1, either alone or in complex with SERPINE1; these interactions are abolished in the presence of LRPAP1/RAP. The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORLA.
messages: Inhibited by SERPINA5.
messages: Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4.
messages: Secreted
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9823:LOC100157689
gene id: 9823:LOC100157689
uniprot id: A0A5G2QWK8
uniprot id: A0A8D1R5L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:MTMR1
gene id: 9823:MTMR1
uniprot id: A0A8D1V330
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9823:RANGRF
gene id: 9823:RANGRF
uniprot id: A0A287AY47
uniprot id: A0A4X1V932
uniprot id: A0A8D1DNT5
names: Similarity
messages: Belongs to the MOG1 family.

9823:EML4
gene id: 9823:EML4
uniprot id: A0A287AHD3
uniprot id: A0A8D0WAP0
uniprot id: A0A8D1LSN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9823:SLC2A8
gene id: 9823:SLC2A8
uniprot id: A0A480HHY7
uniprot id: A0A4X1U9S2
uniprot id: A0A8D1HFS4
uniprot id: F1RS19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane

9823:ARPP19
gene id: 9823:ARPP19
uniprot id: Q712U6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Interacts (when phosphorylated at Ser-62) with PPP2R2D. Interacts with SNCA (By similarity).
messages: Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA (By similarity).
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity).
messages: Ubiquitously expressed.

9823:DLL4
gene id: 9823:DLL4
uniprot id: A0A287BFQ3
uniprot id: A0A4X1URL1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9823:RBP2
gene id: 9823:RBP2
uniprot id: P50121
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: Intracellular transport of retinol.

9823:DHRS7
gene id: 9823:DHRS7
uniprot id: A0A4X1W7G7
uniprot id: F1SSI2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9823:MTM1
gene id: 9823:MTM1
uniprot id: A0A286ZR95
uniprot id: A0A287A329
uniprot id: A0A4X1SXZ1
uniprot id: A0A4X1SY68
uniprot id: A0A8D0TC74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

9823:TUBB4A
gene id: 9823:TUBB4A
uniprot id: A0A480UV25
uniprot id: A0A8D1HA58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9823:AMZ2
gene id: 9823:AMZ2
uniprot id: A0A287AUC9
uniprot id: A0A4X1SRD4
uniprot id: A0A4X1SRE1
uniprot id: A0A8D1DFZ5
uniprot id: F1RV19
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9823:PLP2
gene id: 9823:PLP2
uniprot id: A0A4X1SYJ3
uniprot id: F1RW43
names: Subcellular Location Annotation
messages: Membrane

9823:BMPR1A
gene id: 9823:BMPR1A
uniprot id: A0A4X1VGM2
uniprot id: E9M2M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9823:MRPL1
gene id: 9823:MRPL1
uniprot id: A0A4X1STH0
names: Subcellular Location Annotation
messages: Mitochondrion

9823:RCAN1
gene id: 9823:RCAN1
uniprot id: A0A286ZTF9
uniprot id: A0A4X1TV21
uniprot id: A0A8D1WPN6
uniprot id: F1SGX6
names: Similarity
messages: Belongs to the RCAN family.

9823:DESI2
gene id: 9823:DESI2
uniprot id: A0A287AFM2
uniprot id: A0A4X1T448
uniprot id: A0A4X1T4C3
uniprot id: A0A8D1Q0Z4
uniprot id: A3QRX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DeSI family.
messages: Cytoplasm
messages: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization.
messages: Interacts with RPS7.

9823:SGTB
gene id: 9823:SGTB
uniprot id: A0A286ZNJ9
uniprot id: A0A287A0P2
uniprot id: A0A4X1UQM5
uniprot id: A0A8D2BN54
names: Similarity
messages: Belongs to the SGT family.

9823:TBX4
gene id: 9823:TBX4
uniprot id: F8SIP7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9823:SPP1
gene id: 9823:SPP1
uniprot id: D0G7G0
uniprot id: P14287
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
messages: Belongs to the osteopontin family.
messages: Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif (By similarity). The phosphorylated form inhibits hydroxyapatite crystallization. Dephosphorylation via a mechanism involving ALPL/TNAP promotes hydroxyapatite crystallization (By similarity).
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers, increasing its collagen binding properties.
messages: Ligand for integrin alpha-V/beta-3.
messages: Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
messages: O-glycosylated.
messages: Secreted

9823:FAM206A
gene id: 9823:FAM206A
uniprot id: A0A4X1TH84
uniprot id: F1SP28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9823:PURG
gene id: 9823:PURG
uniprot id: A0A287BDW9
uniprot id: A0A4X1VTE3
uniprot id: A0A4X1VV68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9823:PIM1
gene id: 9823:PIM1
uniprot id: A0A8D1NTU1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9823:IRF2BP1
gene id: 9823:IRF2BP1
uniprot id: A0A8D1AUE3
uniprot id: F1RM42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9823:OLFM4
gene id: 9823:OLFM4
uniprot id: A0A8D1XEM5
uniprot id: F1RJ68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:DDB2
gene id: 9823:DDB2
uniprot id: A0A8D0U1T9
uniprot id: A0A8D0VU03
uniprot id: F1SIC1
uniprot id: I3LK94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

9823:VIM
gene id: 9823:VIM
uniprot id: A0A4X1UCD8
uniprot id: P02543
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Homomer assembled from elementary dimers (By similarity). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity). Interacts with BCAS3 (By similarity). Interacts with LGSN (By similarity). Interacts with SYNM (By similarity). Interacts (via rod region) with PLEC (via CH 1 domain) (By similarity). Interacts with STK33 (By similarity). Interacts with LARP6 (By similarity). Interacts with RAB8B (By similarity). Interacts with TOR1A; the interaction associates TOR1A with the cytoskeleton. Interacts with TOR1AIP1 (By similarity). Interacts with TOR1AIP1 (By similarity). Interacts with DIAPH1 (By similarity). Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament (By similarity). Interacts with the non-receptor tyrosine kinase SRMS; the interaction leads to phosphorylation of VIM (By similarity). Interacts with NOD2 (By similarity). Interacts (via head region) with CORO1C (By similarity). Interacts with HDGF (By similarity). Interacts with PRKCE (via phorbol-ester/DAG-type 2 domain) (By similarity). Interacts with BFSP2 (By similarity). Interacts with PPL (By similarity). Interacts with PKP1 and PKP2 (By similarity).
messages: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
messages: Membrane
messages: Nucleus matrix
messages: One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33. Phosphorylated on tyrosine residues by SRMS.
messages: S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: The central alpha-helical coiled-coil IF rod domain mediates elementary homodimerization.
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
messages: cytoskeleton

9823:ACTR1A
gene id: 9823:ACTR1A
uniprot id: A0A8D1PMN0
names: Similarity
messages: Belongs to the actin family.

9823:GABRE
gene id: 9823:GABRE
uniprot id: A0A8D1J1C9
uniprot id: F1S2D3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9823:GINS3
gene id: 9823:GINS3
uniprot id: A0A4X1UVK0
uniprot id: F1RFT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9823:POLG
gene id: 9823:POLG
uniprot id: A0A8D0TNL2
uniprot id: F1SK24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

9823:DDX50
gene id: 9823:DDX50
uniprot id: A0A481C1W3
uniprot id: A0A4X1TLH4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9823:SAA2
gene id: 9823:SAA2
uniprot id: P0DSO0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apolipoprotein of the HDL complex.
messages: Belongs to the SAA family.
messages: Major acute phase reactant.
messages: Secreted

9823:FTHL17
gene id: 9823:FTHL17
uniprot id: A0A8D1VZ62
uniprot id: F1RXU3
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9823:SPG21
gene id: 9823:SPG21
uniprot id: A0A4X1U0H4
uniprot id: A0A5K1UIX3
names: Function
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9823:EMC9
gene id: 9823:EMC9
uniprot id: A0A8D1IIX8
uniprot id: F1SGM2
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9823:ACR
gene id: 9823:ACR
uniprot id: P08001
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
messages: Belongs to the peptidase S1 family.
messages: Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with SERPINA5 (By similarity).
messages: Inhibited by SERPINA5.

9823:LOC100523049
gene id: 9823:LOC100523049
uniprot id: A0A8D1EL40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:ACAA2
gene id: 9823:ACAA2
uniprot id: A0A8D1PTL2
uniprot id: D0G0B3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9823:LOC100154946
gene id: 9823:LOC100154946
uniprot id: A0A5G2RGI8
names: Similarity
messages: Belongs to the TEX13 family.

9823:GPR18
gene id: 9823:GPR18
uniprot id: A0A286ZWE5
uniprot id: A0A4X1UD68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9823:C1H9orf78
gene id: 9823:C1H9orf78
uniprot id: A0A4X1TFY0
uniprot id: F1RQE0
names: Similarity
messages: Belongs to the TLS1 family.

9823:ARL14
gene id: 9823:ARL14
uniprot id: A0A8D1Q775
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9823:TMED9
gene id: 9823:TMED9
uniprot id: A0A4X1VRG3
uniprot id: F1S3E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:FHL5
gene id: 9823:FHL5
uniprot id: A0A4X1VD49
uniprot id: F1RY03
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9823:IL28B
gene id: 9823:IL28B
uniprot id: A0A8D0R842
uniprot id: D0FHA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9823:GOT1
gene id: 9823:GOT1
uniprot id: A0A1B2TT55
uniprot id: P00503
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:4634443). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity).
messages: Cytoplasm
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9823:CDS2
gene id: 9823:CDS2
uniprot id: A0A4X1UHZ2
uniprot id: D0G6R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9823:ABCG4
gene id: 9823:ABCG4
uniprot id: A0A4X1SFS0
uniprot id: F1SAH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9823:TRPC1
gene id: 9823:TRPC1
uniprot id: A0A4X1T6N8
uniprot id: C0JJ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9823:DDT
gene id: 9823:DDT
uniprot id: A0A4X1V3D9
names: Similarity
messages: Belongs to the MIF family.

9823:EPHA1
gene id: 9823:EPHA1
uniprot id: A0A8D0UYY4
uniprot id: F1SRW1
names: Subcellular Location Annotation
messages: Membrane

9823:MDM1
gene id: 9823:MDM1
uniprot id: A0A4X1VY08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9823:COX10
gene id: 9823:COX10
uniprot id: A0A4X1SQZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

9823:PKM
gene id: 9823:PKM
uniprot id: A0A480JGH8
uniprot id: A0A8D1XH64
uniprot id: A0A8D1XHU8
names: Similarity
messages: Belongs to the pyruvate kinase family.

9823:RIDA
gene id: 9823:RIDA
uniprot id: A0A286ZNH3
uniprot id: A0A4X1TZT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9823:TGM5
gene id: 9823:TGM5
uniprot id: A0A4X1V5M8
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9823:YDJC
gene id: 9823:YDJC
uniprot id: A0A4X1V0J3
uniprot id: F1RKY7
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

9823:NPPC
gene id: 9823:NPPC
uniprot id: P18104
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Degraded by IDE (in vitro).
messages: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By similarity).
messages: Secreted

9823:LYRM2
gene id: 9823:LYRM2
uniprot id: A0A4X1VJB3
uniprot id: F1S0C3
names: Similarity
messages: Belongs to the complex I LYR family.

9823:SLC10A2
gene id: 9823:SLC10A2
uniprot id: A0A287AWP6
uniprot id: A0A4X1U8Z4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

9823:MESDC2
gene id: 9823:MESDC2
uniprot id: A0A4X1UQU5
uniprot id: F1RIE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9823:ACOX2
gene id: 9823:ACOX2
uniprot id: A0A4X1VH96
uniprot id: A0A8D1YSH2
uniprot id: F1SGH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9823:GPR83
gene id: 9823:GPR83
uniprot id: I3RLE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9823:F2R
gene id: 9823:F2R
uniprot id: A7UGA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9823:XKRX
gene id: 9823:XKRX
uniprot id: A0A4X1W3I3
uniprot id: A0A5G2RDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9823:TIMM22
gene id: 9823:TIMM22
uniprot id: A0A8D0P855
uniprot id: F1RHK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9823:SARAF
gene id: 9823:SARAF
uniprot id: A0A287AGS1
uniprot id: A0A8D0SMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9823:TCL1B
gene id: 9823:TCL1B
uniprot id: A0A480Y4S1
uniprot id: A0A4X1SDB8
uniprot id: F1SAR4
names: Similarity
messages: Belongs to the TCL1 family.

9823:EXO1
gene id: 9823:EXO1
uniprot id: A0A4X1T6P3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9823:TNKS
gene id: 9823:TNKS
uniprot id: A0A286ZY03
uniprot id: A0A4X1VTN7
names: Function
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9823:INSL5
gene id: 9823:INSL5
uniprot id: A0A480EQQ5
uniprot id: A0A4X1TZH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9823:LIX1
gene id: 9823:LIX1
uniprot id: A0A8D0TW15
names: Similarity
messages: Belongs to the LIX1 family.

9823:CLCN5
gene id: 9823:CLCN5
uniprot id: Q9GKE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:10978325). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable).
messages: Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.

9823:LOC100153697
gene id: 9823:LOC100153697
uniprot id: A0A0K0KW08
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9823:SCD5
gene id: 9823:SCD5
uniprot id: A0A4X1TFD0
uniprot id: B0FPB3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9823:AFP
gene id: 9823:AFP
uniprot id: A0A480DJQ4
uniprot id: Q8MJ76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin.
messages: Dimeric and trimeric forms have been found in addition to the monomeric form.
messages: Plasma. Synthesized by the fetal liver and yolk sac.
messages: Secreted

9823:C3H16orf71
gene id: 9823:C3H16orf71
uniprot id: F1RK72
names: Function
messages: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.

9823:REEP5
gene id: 9823:REEP5
uniprot id: A0A8D1SAX9
uniprot id: F1RLG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9823:FBXW9
gene id: 9823:FBXW9
uniprot id: F1SEX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9823:CPB2
gene id: 9823:CPB2
uniprot id: A0A4X1SEJ1
uniprot id: F1RK01
names: Similarity
messages: Belongs to the peptidase M14 family.

9823:CENPM
gene id: 9823:CENPM
uniprot id: A0A4X1W3K9
uniprot id: C1K0H9
names: Subcellular Location Annotation
messages: Nucleus

9823:CUL5
gene id: 9823:CUL5
uniprot id: A0A4X1VMQ4
uniprot id: A0A4X1VNP2
uniprot id: I3LFR2
names: Similarity
messages: Belongs to the cullin family.

9823:SOD1
gene id: 9823:SOD1
uniprot id: D9D839
uniprot id: P04178
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.
messages: Nucleus
messages: Palmitoylation helps nuclear targeting and decreases catalytic activity.
messages: Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.

9823:ERH
gene id: 9823:ERH
uniprot id: A0A8D1UEG1
uniprot id: F2Z5J5
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9823:LIN7C
gene id: 9823:LIN7C
uniprot id: A0A8D0YQY9
uniprot id: F2Z5M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9823:LSM5
gene id: 9823:LSM5
uniprot id: A0A286ZSU0
uniprot id: A0A4X1SQM6
uniprot id: A0A8D1D312
uniprot id: I3LM25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9823:PPP3CC
gene id: 9823:PPP3CC
uniprot id: A0A481CE02
uniprot id: A0A4X1VFL0
uniprot id: A0A4X1VGK6
uniprot id: A0A8D0PBE4
uniprot id: A0A8D1BQN9
uniprot id: A0A8D1NXA8
uniprot id: F1RMA8
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9823:VPS41
gene id: 9823:VPS41
uniprot id: A0A4X1UMY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9823:FAM173A
gene id: 9823:FAM173A
uniprot id: A0A4X1SVX7
uniprot id: F1RG48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9823:ARF1
gene id: 9823:ARF1
uniprot id: A0A4X1UMF7
uniprot id: C4MXZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9823:C6H1orf174
gene id: 9823:C6H1orf174
uniprot id: A0A4X1W8Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9823:PRLR
gene id: 9823:PRLR
uniprot id: A0A8D0ZCE3
uniprot id: Q6JTA8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9823:ADA2
gene id: 9823:ADA2
uniprot id: P58780
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity).
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Binds 1 zinc ion per subunit.
messages: High-affinity binding to heparin/glycosaminoclycan (GAG) is mediated by a large, highly positively charged surface at the interface of dimer's subunits involving approximately residues 25-40, 386-393, and 419-425.
messages: Homodimer. Interacts with adenosine receptors. Binds heparin (By similarity).
messages: Secreted
messages: The PRB domain is involved in receptor binding, and may be responsible for the cytokine-like growth factor activity due to it's sharing of several structural properties with chemokines.

9823:FASN
gene id: 9823:FASN
uniprot id: A5YV76
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

9823:SNCB
gene id: 9823:SNCB
uniprot id: A0A4X1SIN8
uniprot id: A8QW48
names: Similarity
messages: Belongs to the synuclein family.

9823:HMX3
gene id: 9823:HMX3
uniprot id: A0A287BAL6
uniprot id: A0A8D1WEB6
names: Subcellular Location Annotation
messages: Nucleus

9823:LOC100151901
gene id: 9823:LOC100151901
uniprot id: A0A4X1V1L8
uniprot id: F1RL35
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9823:ABCD3
gene id: 9823:ABCD3
uniprot id: A0A480TDD6
uniprot id: A0A4X1TYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9823:MAP2
gene id: 9823:MAP2
uniprot id: A0A286ZLW8
uniprot id: A0A287B3S9
uniprot id: A0A4X1UTD5
uniprot id: A0A8D0YQA1
uniprot id: A0A8D1VPX4
uniprot id: A0A8D1ZII2
uniprot id: A0A8D2CD15
uniprot id: F1SSS6
names: Subcellular Location Annotation
messages: cytoskeleton

9823:TNFSF4
gene id: 9823:TNFSF4
uniprot id: A0A8D0SK41
uniprot id: Q4QTJ8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9823:UBLCP1
gene id: 9823:UBLCP1
uniprot id: A0A287BNL3
uniprot id: A0A4X1U0B0
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9823:ITGB8
gene id: 9823:ITGB8
uniprot id: A4GUC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9823:C18H7orf25
gene id: 9823:C18H7orf25
uniprot id: F1SSE3
names: Similarity
messages: Belongs to the UPF0415 family.

9823:MUT
gene id: 9823:MUT
uniprot id: Q8MI68
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.
messages: Cytoplasm
messages: Homodimer. Interacts (the apoenzyme form) with MMAA; the interaction is GTP dependent.
messages: Inhibited by itaconyl-CoA, a metabolite that inactivates the coenzyme B12 cofactor.
messages: Mitochondrion
messages: Mitochondrion matrix

9823:SUMO1
gene id: 9823:SUMO1
uniprot id: A7WLH8
uniprot id: B0M1N0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
messages: Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (By similarity). Interacts with SAE2, RANBP2, PIAS1 and PIAS2 (By similarity). Interacts with PRKN (By similarity). Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG (By similarity). Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25 (By similarity). Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains) (By similarity). Interacts with BHLHE40/DEC1 (By similarity). Interacts with RWDD3 (By similarity). Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (By similarity). Interacts with MTA1 (By similarity). Interacts with SENP2 (By similarity). Interacts with HINT1 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Polymeric SUMO1 chains undergo polyubiquitination by RNF4.
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3.

9823:GATA6
gene id: 9823:GATA6
uniprot id: A0A4X1VNF0
uniprot id: F1SBC0
uniprot id: Q95JA5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with LMCD1.
messages: Nucleus
messages: The GATA-type zinc fingers mediate interaction with LMCD1.
messages: Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.

9823:HPRT1
gene id: 9823:HPRT1
uniprot id: B0LXK8
uniprot id: Q45FY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.
messages: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
messages: Cytoplasm
messages: Homotetramer.

9823:VTN
gene id: 9823:VTN
uniprot id: P48819
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
messages: Monomer. Interacts with SERPINE1/PAI1 and C1QBP (By similarity).
messages: N- and O-glycosylated.
messages: Plasma.
messages: Sulfated on tyrosine residues.
messages: The SMB domain mediates interaction with SERPINE1/PAI1.
messages: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity).
messages: extracellular space

9823:NMBR
gene id: 9823:NMBR
uniprot id: A0A8D1SFR2
uniprot id: B2ZI34
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: During the sow estrus cycle, highest levels are found in the hypothalamus at proestrus and estrus with a significant drop at metestrus and an increase at diestrus. In the pituitary gland, expression increases from proestrus to estrus, drops at metestrus and increases at diestrus. In the ovary, expression increases from proestrus to estrus, drops at metestrus and remains at a similar level at diestrus. During boar postnatal development, expression peaks in the hypothalamus at day 30 and decreases thereafter. In the pituitary gland, expression peaks at day 60, drops slightly at day 90 and increases again at day 120. In the testis, expression drops from day 3 to day 30 with peak levels at day 90 and a decrease at day 120.
messages: Highly expressed in peripheral tissues where it is detected in the respiratory system, circulatory system, digestive system, urogenital system, lymphatic organs and endocrine system (at protein level) (PubMed:27010315). In the testis, expressed mainly in Leydig cells (at protein level) (PubMed:29632025).
messages: Membrane
messages: Receptor for neuromedin-B (By similarity). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (By similarity). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).

9823:ILK
gene id: 9823:ILK
uniprot id: A0A480Q0Y5
uniprot id: A0A4X1SGZ5
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9823:BTG3
gene id: 9823:BTG3
uniprot id: A4UTQ2
names: Function
names: Similarity
messages: Belongs to the BTG family.
messages: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.

9823:STOML1
gene id: 9823:STOML1
uniprot id: A0A8D1I1I8
uniprot id: A0A8D1M8E1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9823:CCL25
gene id: 9823:CCL25
uniprot id: Q4PR21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).
messages: Secreted

9823:RPS3A
gene id: 9823:RPS3A
uniprot id: B6V8C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9823:KCNJ13
gene id: 9823:KCNJ13
uniprot id: A0A4X1U1W9
uniprot id: I3LPQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9823:CDH12
gene id: 9823:CDH12
uniprot id: A0A4X1TLK8
uniprot id: F1SRL7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9823:PLA2G4B
gene id: 9823:PLA2G4B
uniprot id: A0A4X1V0R9
uniprot id: F1SSW8
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9823:SLC46A3
gene id: 9823:SLC46A3
uniprot id: A0A4X1TKX8
uniprot id: M3UZC6
names: Subcellular Location Annotation
messages: Membrane

9823:PRDM12
gene id: 9823:PRDM12
uniprot id: A0A4X1TCS3
uniprot id: F1S0X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

9823:CTPS1
gene id: 9823:CTPS1
uniprot id: A0A287B3Y5
uniprot id: A0A4X1W5M1
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9823:GPR39
gene id: 9823:GPR39
uniprot id: B2ZHY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).

9823:DPAGT1
gene id: 9823:DPAGT1
uniprot id: A0A4X1SFQ6
uniprot id: F1SAH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9823:P4HA2
gene id: 9823:P4HA2
uniprot id: A0A4X1UQU2
uniprot id: A0A4X1UR01
uniprot id: I3L5Y0
uniprot id: I3L769
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9823:PVALB
gene id: 9823:PVALB
uniprot id: F1SKJ8
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9823:FES
gene id: 9823:FES
uniprot id: A0A4X1UGS1
uniprot id: F1RMJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

9823:SLITRK5
gene id: 9823:SLITRK5
uniprot id: A0A8D1X532
names: Similarity
messages: Belongs to the SLITRK family.

9823:EIPR1
gene id: 9823:EIPR1
uniprot id: A0A480LI92
uniprot id: A0A8D1NZ97
uniprot id: A0A8D1TRG7
uniprot id: I3LHX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

9823:NRN1
gene id: 9823:NRN1
uniprot id: A0A4X1SJ65
uniprot id: A0A4X1SKJ6
uniprot id: A0A5G2RN46
uniprot id: F1RW81
names: Similarity
messages: Belongs to the neuritin family.

9823:RETNLB
gene id: 9823:RETNLB
uniprot id: A0A4X1SQJ0
uniprot id: A7XNM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9823:NDUFB11
gene id: 9823:NDUFB11
uniprot id: A0A8D1EYI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

9823:MAN2A2
gene id: 9823:MAN2A2
uniprot id: A0A8D0PX15
uniprot id: A0A8D0Q4L9
uniprot id: F1RMI9
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9823:PLLP
gene id: 9823:PLLP
uniprot id: A0A4X1SDQ5
uniprot id: F1RF33
names: Subcellular Location Annotation
messages: Membrane

9823:SLA-3
gene id: 9823:SLA-3
uniprot id: Q8MHT9
names: Similarity
messages: Belongs to the MHC class I family.

9823:KAT8
gene id: 9823:KAT8
uniprot id: A0A4X1TIU6
uniprot id: F1RIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9823:TMSB10
gene id: 9823:TMSB10
uniprot id: P21753
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
messages: cytoskeleton

9823:NME5
gene id: 9823:NME5
uniprot id: A0A8D0HQU0
uniprot id: A0A8D0ZP73
uniprot id: I3LN92
names: Similarity
messages: Belongs to the NDK family.

9823:OPN1SW
gene id: 9823:OPN1SW
uniprot id: Q8MIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9823:LPAR2
gene id: 9823:LPAR2
uniprot id: A0A286ZX94
uniprot id: A0A4X1U1Q6
uniprot id: C5G5X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9823:EMX2
gene id: 9823:EMX2
uniprot id: A0A8D1NRH5
names: Subcellular Location Annotation
messages: Nucleus

9823:SERPING1
gene id: 9823:SERPING1
uniprot id: A0A8D1R369
uniprot id: A0PA00
uniprot id: F1SJW8
names: Similarity
messages: Belongs to the serpin family.

9823:LOC100510971
gene id: 9823:LOC100510971
uniprot id: A0A4X1V733
uniprot id: F1RHR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:TMEM53
gene id: 9823:TMEM53
uniprot id: A0A4X1W9T2
uniprot id: A0A5G2RAB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9823:IGF2R
gene id: 9823:IGF2R
uniprot id: F8UQW4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9823:FOXE1
gene id: 9823:FOXE1
uniprot id: A0A8D1AD46
uniprot id: F1SSG9
names: Subcellular Location Annotation
messages: Nucleus

9823:TMEM38B
gene id: 9823:TMEM38B
uniprot id: A0A286ZVK0
uniprot id: A0A4X1VCW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9823:HEXIM1
gene id: 9823:HEXIM1
uniprot id: A0A5G2RFM4
uniprot id: A0A8D0RYW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9823:PCSK1
gene id: 9823:PCSK1
uniprot id: Q28959
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9823:TTYH2
gene id: 9823:TTYH2
uniprot id: A0A287BMC9
uniprot id: A0A480XSM7
uniprot id: A0A8D0XYH2
uniprot id: A0A8D0Y1C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9823:NOSIP
gene id: 9823:NOSIP
uniprot id: A0A4X1VYM4
uniprot id: A0A5G2QVZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

9823:NACC1
gene id: 9823:NACC1
uniprot id: A0A4X1T1D9
uniprot id: F1SD83
names: Subcellular Location Annotation
messages: Nucleus

9823:MAGI3
gene id: 9823:MAGI3
uniprot id: A0A287BIU8
uniprot id: A0A4X1T4I1
uniprot id: A0A4X1T4L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9823:TXLNB
gene id: 9823:TXLNB
uniprot id: A0A287A996
uniprot id: A0A8D1CRE1
names: Similarity
messages: Belongs to the taxilin family.

9823:SELENOW
gene id: 9823:SELENOW
uniprot id: Q95KL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SelWTH family. Selenoprotein W subfamily.
messages: Cytoplasm
messages: Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.
messages: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

9823:ST6GALNAC1
gene id: 9823:ST6GALNAC1
uniprot id: A0A8D1Q1S8
uniprot id: F1RZ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9823:ZDHHC23
gene id: 9823:ZDHHC23
uniprot id: A0A4X1SX72
uniprot id: A0A5G2QJZ2
uniprot id: A0A8D1Q3V4
uniprot id: F1SP96
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9823:LOC100152489
gene id: 9823:LOC100152489
uniprot id: A0A287A6J1
uniprot id: A0A4X1VEA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9823:CNDP2
gene id: 9823:CNDP2
uniprot id: A0A4X1U2W5
uniprot id: F1SNL7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9823:TPRKB
gene id: 9823:TPRKB
uniprot id: A0A4X1W6R1
uniprot id: A0A8D1U1Z8
uniprot id: B8Y649
uniprot id: F6QAE4
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9823:MDK
gene id: 9823:MDK
uniprot id: A0A8D1BER4
uniprot id: A0A8D1BSI8
uniprot id: D3K5N3
names: Similarity
messages: Belongs to the pleiotrophin family.

9823:LHB
gene id: 9823:LHB
uniprot id: P01232
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
messages: Secreted

9823:CALB1
gene id: 9823:CALB1
uniprot id: A0A4X1UCH9
uniprot id: B3VFB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

9823:PSMB11
gene id: 9823:PSMB11
uniprot id: A0A4X1V3X5
uniprot id: F1S9C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus