9796:GTF2A1L
gene id: 9796:GTF2A1L
uniprot id: A0A3Q2HH64
uniprot id: F6QVL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9796:TOB2
gene id: 9796:TOB2
uniprot id: F7DRN7
names: Similarity
messages: Belongs to the BTG family.

9796:CXCL1
gene id: 9796:CXCL1
uniprot id: F6R8V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9796:ATP6V1C1
gene id: 9796:ATP6V1C1
uniprot id: F6RUH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9796:CPSF2
gene id: 9796:CPSF2
uniprot id: F6YTB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9796:NKX2-2
gene id: 9796:NKX2-2
uniprot id: F7A4A4
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100065192
gene id: 9796:LOC100065192
uniprot id: A0A3Q2HCU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9796:RBM48
gene id: 9796:RBM48
uniprot id: A0A5F5PUW9
names: Similarity
messages: Belongs to the RBM48 family.

9796:PTGER2
gene id: 9796:PTGER2
uniprot id: B2KNE0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:PTGDR2
gene id: 9796:PTGDR2
uniprot id: F6TM20
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:FOXJ2
gene id: 9796:FOXJ2
uniprot id: F7DC87
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100068580
gene id: 9796:LOC100068580
uniprot id: F6U7Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100630862
gene id: 9796:LOC100630862
uniprot id: A0A3Q2HUL7
names: Similarity
messages: Belongs to the pro/parathymosin family.

9796:CYBB
gene id: 9796:CYBB
uniprot id: F7DA90
names: Subcellular Location Annotation
messages: Membrane

9796:ENDOU
gene id: 9796:ENDOU
uniprot id: A0A3Q2L888
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

9796:NR0B1
gene id: 9796:NR0B1
uniprot id: F6RS99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9796:ITGB1
gene id: 9796:ITGB1
uniprot id: A0A3Q2IDL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Cell surface
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9796:MFN1
gene id: 9796:MFN1
uniprot id: F6VTU8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9796:SEPSECS
gene id: 9796:SEPSECS
uniprot id: F6Q7N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9796:CHGA
gene id: 9796:CHGA
uniprot id: F7BS54
uniprot id: Q9XS63
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Binds calcium with a low-affinity.
messages: Highly expressed in adrenal medulla and pituitary gland. Weaker expression detected in cerebrum, cerebellum, spinal cord, liver, thyroid gland, striated muscle, lung, spleen, kidney, parotid gland, and sublingual gland.
messages: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.
messages: Interacts with SCG3.
messages: O-glycosylated.
messages: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
messages: Secreted
messages: Strongly inhibits glucose induced insulin release from the pancreas.
messages: neuronal dense core vesicle
messages: secretory vesicle

9796:LGI3
gene id: 9796:LGI3
uniprot id: F7CJB5
names: Subcellular Location Annotation
messages: Secreted

9796:C20H6orf89
gene id: 9796:C20H6orf89
uniprot id: A0A3Q2GW88
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9796:TNP1
gene id: 9796:TNP1
uniprot id: F7DPN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Nucleus

9796:HTR3A
gene id: 9796:HTR3A
uniprot id: F7D7A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9796:FMO2
gene id: 9796:FMO2
uniprot id: A0A5F5PML4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

9796:THG1L
gene id: 9796:THG1L
uniprot id: F7AGP0
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

9796:CA5B
gene id: 9796:CA5B
uniprot id: A0A3Q2LE53
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9796:NCAPG
gene id: 9796:NCAPG
uniprot id: F7E010
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9796:SLC2A12
gene id: 9796:SLC2A12
uniprot id: F7DHN3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9796:KCNH8
gene id: 9796:KCNH8
uniprot id: F6TKX5
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9796:SLC15A1
gene id: 9796:SLC15A1
uniprot id: F6SG69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9796:MTFP1
gene id: 9796:MTFP1
uniprot id: F6RQS3
names: Similarity
messages: Belongs to the MTFP1 family.

9796:GUCA2B
gene id: 9796:GUCA2B
uniprot id: F6S6Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9796:FRAS1
gene id: 9796:FRAS1
uniprot id: F6W7F3
names: Similarity
messages: Belongs to the FRAS1 family.

9796:UFM1
gene id: 9796:UFM1
uniprot id: A0A5F5PS47
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9796:TAF11
gene id: 9796:TAF11
uniprot id: F6YGQ1
names: Similarity
messages: Belongs to the TAF11 family.

9796:LOC100060387
gene id: 9796:LOC100060387
uniprot id: F6QWE5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TFIP11
gene id: 9796:TFIP11
uniprot id: F6TXE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9796:LOC100069622
gene id: 9796:LOC100069622
uniprot id: F6WW72
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:KRT15
gene id: 9796:KRT15
uniprot id: F6PJX6
names: Similarity
messages: Belongs to the intermediate filament family.

9796:AP1B1
gene id: 9796:AP1B1
uniprot id: A0A3Q2L5B6
uniprot id: F7CLY2
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9796:BATF
gene id: 9796:BATF
uniprot id: F6W196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9796:EPO
gene id: 9796:EPO
uniprot id: Q867B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Secreted

9796:LOC100068387
gene id: 9796:LOC100068387
uniprot id: F6UP85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HOXA9
gene id: 9796:HOXA9
uniprot id: F6U6C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9796:EIF4EBP1
gene id: 9796:EIF4EBP1
uniprot id: A0A3Q2HCV3
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9796:OTUB2
gene id: 9796:OTUB2
uniprot id: F6Y8Y0
names: Similarity
messages: Belongs to the peptidase C65 family.

9796:DHRS7B
gene id: 9796:DHRS7B
uniprot id: A0A3Q2LHN3
uniprot id: A0A5F5PRL2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:PPP4C
gene id: 9796:PPP4C
uniprot id: F6X854
names: Similarity
messages: Belongs to the PPP phosphatase family.

9796:LOC100034197
gene id: 9796:LOC100034197
uniprot id: Q95182
names: Allergen
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Analysis of the sugar composition shows the presence of GalNAc, Gal, NeuAc, GlcNAc, and Man. May be also O-glycosylated.
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Causes an allergic reaction in human. Potent allergen responsible for about 80% of anti-horse IgE antibody response in patients who are chronically exposed to horse allergens.
messages: Expressed in liver and in sublingual and submaxillary salivary glands. Highly concentrated in secretory fluid such as saliva and urine as well as in hair dandruff extract.
messages: Homodimer.
messages: Secreted
messages: Several N-terminal ends may be due to cleavage by signal peptidase at different sites or may be generated by proteolytic processing of the secreted protein.

9796:ALDH1A3
gene id: 9796:ALDH1A3
uniprot id: F6Y0Q6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9796:KEF40 p13
gene id: 9796:KEF40_p13
uniprot id: P48652
uniprot id: Q6J6X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9796:FRRS1
gene id: 9796:FRRS1
uniprot id: A0A3Q2ILR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9796:NODAL
gene id: 9796:NODAL
uniprot id: F6Y3I3
names: Similarity
messages: Belongs to the TGF-beta family.

9796:HEXIM1
gene id: 9796:HEXIM1
uniprot id: F7DSW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9796:TNFAIP6
gene id: 9796:TNFAIP6
uniprot id: Q29XY3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:ANXA2
gene id: 9796:ANXA2
uniprot id: B2B9I8
uniprot id: K9K271
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
messages: Membrane
messages: basement membrane

9796:CSF1R
gene id: 9796:CSF1R
uniprot id: Q4W447
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9796:CENPJ
gene id: 9796:CENPJ
uniprot id: A0A3Q2HEL6
uniprot id: F7BLW8
names: Similarity
messages: Belongs to the TCP10 family.

9796:ZNF277
gene id: 9796:ZNF277
uniprot id: F7CFG6
names: Similarity
messages: Belongs to the ZNF277 family.

9796:SLA
gene id: 9796:SLA
uniprot id: A0A3Q2GZ94
names: Subcellular Location Annotation
messages: Cytoplasm

9796:LOC100066505
gene id: 9796:LOC100066505
uniprot id: A0A3Q2L1G7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:MPZ
gene id: 9796:MPZ
uniprot id: Q6WEB5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Homodimer and homotetramer.
messages: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
messages: N-glycosylated; contains sulfate-substituted glycan.

9796:ATP1A1
gene id: 9796:ATP1A1
uniprot id: A0A3Q2GSX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9796:FAM162B
gene id: 9796:FAM162B
uniprot id: F7B149
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9796:MARF1
gene id: 9796:MARF1
uniprot id: F7BA19
names: Subcellular Location Annotation
messages: Peroxisome

9796:STARD6
gene id: 9796:STARD6
uniprot id: F7AEQ6
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9796:SPATA6
gene id: 9796:SPATA6
uniprot id: F7CZ71
names: Similarity
messages: Belongs to the SPATA6 family.

9796:LOC100062796
gene id: 9796:LOC100062796
uniprot id: A0A3Q2L7S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:IFNB1
gene id: 9796:IFNB1
uniprot id: A0A7R8C3S1
uniprot id: P05012
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family.
messages: Monomer.
messages: Secreted
messages: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).

9796:TLE3
gene id: 9796:TLE3
uniprot id: F7DDI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9796:ODF2
gene id: 9796:ODF2
uniprot id: F6U2V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9796:KATNAL2
gene id: 9796:KATNAL2
uniprot id: F6PIY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

9796:LOC100067905
gene id: 9796:LOC100067905
uniprot id: F6QZX8
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:DDX6
gene id: 9796:DDX6
uniprot id: F7CXI1
names: Similarity
messages: Belongs to the DEAD box helicase family.

9796:LOC100052445
gene id: 9796:LOC100052445
uniprot id: F6TI41
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:LIN52
gene id: 9796:LIN52
uniprot id: F6VSX0
names: Similarity
messages: Belongs to the lin-52 family.

9796:NAPG
gene id: 9796:NAPG
uniprot id: F6ZPN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9796:CDKAL1
gene id: 9796:CDKAL1
uniprot id: F6PJ52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9796:LOC100058685
gene id: 9796:LOC100058685
uniprot id: F7DY67
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9796:OPALIN
gene id: 9796:OPALIN
uniprot id: A0A3Q2HXY6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9796:ALDH18A1
gene id: 9796:ALDH18A1
uniprot id: F6PT43
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9796:OSBPL1A
gene id: 9796:OSBPL1A
uniprot id: F7CW96
names: Similarity
messages: Belongs to the OSBP family.

9796:RBKS
gene id: 9796:RBKS
uniprot id: F6VST9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9796:IL4R
gene id: 9796:IL4R
uniprot id: Q6WG24
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
messages: On IL4 binding, phosphorylated on tyrosine residues in the cytoplasmic domain.
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity).
messages: Secreted
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling. Interacts with JAK3. Interacts with CLM1.

9796:MYH7
gene id: 9796:MYH7
uniprot id: F6YJN7
uniprot id: Q8MJU9
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with ECPAS. Interacts (via C-terminus) with LRRC39.
messages: Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).
messages: The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Four skip residues (Skip1: Thr-1188, Skip2: Glu-1385, Skip3: Glu-1582 and Skip4: Gly-1807) introduce discontinuities in the coiled-coil heptad repeats. The first three skip residues are structurally comparable and induce a unique local relaxation of the coiled-coil superhelical pitch and the fourth skip residue lies within a highly flexible molecular hinge that is necessary for myosin incorporation in the bare zone of sarcomeres.
messages: myofibril
messages: sarcomere

9796:SF3A1
gene id: 9796:SF3A1
uniprot id: F6Y642
names: Subcellular Location Annotation
messages: Nucleus

9796:USP21
gene id: 9796:USP21
uniprot id: F6XCS2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9796:CAMK2A
gene id: 9796:CAMK2A
uniprot id: A0A3Q2H2A7
uniprot id: F7CJA9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9796:SH3YL1
gene id: 9796:SH3YL1
uniprot id: A0A3Q2I5L5
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9796:LOC100061262
gene id: 9796:LOC100061262
uniprot id: F6WNR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DNASE1L1
gene id: 9796:DNASE1L1
uniprot id: F6QK77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Nucleus envelope
messages: Zymogen granule

9796:KRTCAP2
gene id: 9796:KRTCAP2
uniprot id: F6VN82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9796:IFNE
gene id: 9796:IFNE
uniprot id: A0A7R8C517
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:NBR1
gene id: 9796:NBR1
uniprot id: A0A3Q2H8U4
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9796:RNF40
gene id: 9796:RNF40
uniprot id: F7BI96
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9796:MPHOSPH10
gene id: 9796:MPHOSPH10
uniprot id: F7B222
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9796:STOML1
gene id: 9796:STOML1
uniprot id: F7BUI0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9796:IL17B
gene id: 9796:IL17B
uniprot id: F6ZF52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9796:TMEM192
gene id: 9796:TMEM192
uniprot id: F7BA32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9796:KRT81
gene id: 9796:KRT81
uniprot id: F6ST15
names: Similarity
messages: Belongs to the intermediate filament family.

9796:ATP6V0B
gene id: 9796:ATP6V0B
uniprot id: F6XRF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9796:CHST3
gene id: 9796:CHST3
uniprot id: F6WF01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9796:PHB2
gene id: 9796:PHB2
uniprot id: F6XXH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9796:DDX21
gene id: 9796:DDX21
uniprot id: F6ZZU6
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9796:PRKAB2
gene id: 9796:PRKAB2
uniprot id: Q2LGF6
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9796:RPS6KB2
gene id: 9796:RPS6KB2
uniprot id: F6Q7I1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:BCCIP
gene id: 9796:BCCIP
uniprot id: F6QQH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

9796:MSRB2
gene id: 9796:MSRB2
uniprot id: F6SG40
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9796:NOL10
gene id: 9796:NOL10
uniprot id: F6U0I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9796:NUS1
gene id: 9796:NUS1
uniprot id: F7DQU7
names: Similarity
messages: Belongs to the UPP synthase family.

9796:ITIH1
gene id: 9796:ITIH1
uniprot id: F6QX36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9796:HOXB7
gene id: 9796:HOXB7
uniprot id: F7AGE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9796:NUP62
gene id: 9796:NUP62
uniprot id: F6Z9U7
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

9796:SYNPR
gene id: 9796:SYNPR
uniprot id: F6ZN38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9796:PATL1
gene id: 9796:PATL1
uniprot id: A0A3Q2IFT8
uniprot id: F6ZK93
names: Similarity
messages: Belongs to the PAT1 family.

9796:PHOX2A
gene id: 9796:PHOX2A
uniprot id: F6XD52
names: Subcellular Location Annotation
messages: Nucleus

9796:PARPBP
gene id: 9796:PARPBP
uniprot id: F6YLY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9796:GDPD1
gene id: 9796:GDPD1
uniprot id: F6U0M2
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9796:CFAP36
gene id: 9796:CFAP36
uniprot id: F6YD57
names: Similarity
messages: Belongs to the CFAP36 family.

9796:SAA1
gene id: 9796:SAA1
uniprot id: F6ZL17
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9796:SPSB1
gene id: 9796:SPSB1
uniprot id: A0A3Q2LMQ2
names: Similarity
messages: Belongs to the SPSB family.

9796:TATDN2
gene id: 9796:TATDN2
uniprot id: A0A5F5Q2T4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9796:PARP14
gene id: 9796:PARP14
uniprot id: F6S1K6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9796:IZUMO3
gene id: 9796:IZUMO3
uniprot id: F7BAE4
names: Similarity
messages: Belongs to the Izumo family.

9796:AMBP
gene id: 9796:AMBP
uniprot id: A0A5F5PEG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9796:LOC100070801
gene id: 9796:LOC100070801
uniprot id: F7CW37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:STAT2
gene id: 9796:STAT2
uniprot id: F6U1D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9796:ANG
gene id: 9796:ANG
uniprot id: Q5VI84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pancreatic ribonuclease family.
messages: Homodimer. Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur (By similarity).
messages: Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
messages: Secreted
messages: nucleolus
messages: secretory vesicle lumen

9796:TSPYL1
gene id: 9796:TSPYL1
uniprot id: F6WJS9
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9796:B2M
gene id: 9796:B2M
uniprot id: K9K497
uniprot id: P30441
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

9796:SFXN5
gene id: 9796:SFXN5
uniprot id: A0A3Q2H1I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9796:USP26
gene id: 9796:USP26
uniprot id: F7DAL9
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9796:RPL27A
gene id: 9796:RPL27A
uniprot id: F7B3L3
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9796:LOC100067320
gene id: 9796:LOC100067320
uniprot id: F6VDB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:IL6R
gene id: 9796:IL6R
uniprot id: F6Y7E0
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9796:GADL1
gene id: 9796:GADL1
uniprot id: A0A3Q2GYW5
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9796:BORCS7
gene id: 9796:BORCS7
uniprot id: A0A5K1UV87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Membrane

9796:AQP1
gene id: 9796:AQP1
uniprot id: F6WM25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
messages: Membrane

9796:SGSM3
gene id: 9796:SGSM3
uniprot id: F7AXJ3
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

9796:SLC7A11
gene id: 9796:SLC7A11
uniprot id: F6SEZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9796:STMN2
gene id: 9796:STMN2
uniprot id: F7CII9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Membrane
messages: lamellipodium

9796:LOC100064915
gene id: 9796:LOC100064915
uniprot id: F6R411
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SURF6
gene id: 9796:SURF6
uniprot id: F6T8R5
names: Similarity
messages: Belongs to the SURF6 family.

9796:CCNB1
gene id: 9796:CCNB1
uniprot id: F6T9K2
names: Similarity
messages: Belongs to the cyclin family.

9796:SH3RF2
gene id: 9796:SH3RF2
uniprot id: F6YV64
names: Similarity
messages: Belongs to the SH3RF family.

9796:ACP1
gene id: 9796:ACP1
uniprot id: A0A5F5PM56
uniprot id: F6RLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9796:NEFL
gene id: 9796:NEFL
uniprot id: F6W6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: cytoskeleton

9796:PPP1R1C
gene id: 9796:PPP1R1C
uniprot id: F6YZP0
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9796:USH1G
gene id: 9796:USH1G
uniprot id: F6UQZ1
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9796:CLPS
gene id: 9796:CLPS
uniprot id: F6SDT9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9796:SENP2
gene id: 9796:SENP2
uniprot id: A0A3Q2H6N7
names: Similarity
messages: Belongs to the peptidase C48 family.

9796:LOC100059831
gene id: 9796:LOC100059831
uniprot id: A0A3Q2HXW7
names: Similarity
messages: Belongs to the DEAD box helicase family.

9796:IFN-ALPHA2
gene id: 9796:IFN-ALPHA2
uniprot id: A0A3Q2KSE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:CDH7
gene id: 9796:CDH7
uniprot id: F6U735
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9796:CDC25C
gene id: 9796:CDC25C
uniprot id: A0A3Q2IEC0
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9796:TLR8
gene id: 9796:TLR8
uniprot id: A8QM58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9796:SCFD1
gene id: 9796:SCFD1
uniprot id: F7CTQ1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9796:CD2
gene id: 9796:CD2
uniprot id: P37998
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
messages: Cell membrane
messages: Expressed in spleen and thymus.
messages: Interacts with CD48 (By similarity). Interacts with CD58 (LFA-3) (By similarity). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (By similarity). Interacts with FCGR3A; this interaction modulates NK cell activation and cytotoxicity.

9796:ABCG5
gene id: 9796:ABCG5
uniprot id: F7BX14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9796:LOC100058670
gene id: 9796:LOC100058670
uniprot id: F7AB75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100054211
gene id: 9796:LOC100054211
uniprot id: A0A3Q2ID58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:CLTRN
gene id: 9796:CLTRN
uniprot id: A0A5F5PUR2
uniprot id: F7DYY2
names: Subcellular Location Annotation
messages: Membrane

9796:CLDN14
gene id: 9796:CLDN14
uniprot id: F7AHT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:LOC100068425
gene id: 9796:LOC100068425
uniprot id: F6TVP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100068026
gene id: 9796:LOC100068026
uniprot id: F6SNT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9796:PLA2G1B
gene id: 9796:PLA2G1B
uniprot id: F6YYL8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9796:PFDN6
gene id: 9796:PFDN6
uniprot id: F6SFR8
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9796:CFAP97D1
gene id: 9796:CFAP97D1
uniprot id: F6T0K7
names: Similarity
messages: Belongs to the CFAP97 family.

9796:SGMS1
gene id: 9796:SGMS1
uniprot id: A0A3Q2HBE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9796:EDN2
gene id: 9796:EDN2
uniprot id: Q867D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides.
messages: Secreted

9796:LOC100058940
gene id: 9796:LOC100058940
uniprot id: F6PVD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9796:MINDY1
gene id: 9796:MINDY1
uniprot id: F6Y5P3
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9796:MDH2
gene id: 9796:MDH2
uniprot id: F6TYW4
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

9796:KPNA2
gene id: 9796:KPNA2
uniprot id: A0A3Q2H8G1
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9796:POT1
gene id: 9796:POT1
uniprot id: A0A3Q2I778
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9796:KIF15
gene id: 9796:KIF15
uniprot id: F6V4Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: spindle

9796:EAF2
gene id: 9796:EAF2
uniprot id: A0A3Q2HKI0
names: Similarity
messages: Belongs to the EAF family.

9796:MME
gene id: 9796:MME
uniprot id: F7B8E7
names: Cofactor
messages: Binds 1 zinc ion per subunit.

9796:UBA52
gene id: 9796:UBA52
uniprot id: A0A0B4J1C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Ribosomal protein L40 is part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).

9796:GBE1
gene id: 9796:GBE1
uniprot id: Q6EAS5
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Binds its carbohydrate substrate close to the active site, but also via regions close to the N-terminus; this may result in increased affinity and therefore increased catalytic efficiency.
messages: Defects in GBE1 are the cause of glycogen storage disease IV (GSD-IV). GSD-IV is recessive fatal fetal and neonatal disease in American Quarter horses.
messages: Monomer.
messages: Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule.

9796:STAC3
gene id: 9796:STAC3
uniprot id: F6XWB7
names: Subcellular Location Annotation
messages: sarcolemma

9796:GJB6
gene id: 9796:GJB6
uniprot id: A0A654IDL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:RNASEH2A
gene id: 9796:RNASEH2A
uniprot id: F7CGP4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9796:UCP3
gene id: 9796:UCP3
uniprot id: F6Y401
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:KCND1
gene id: 9796:KCND1
uniprot id: F7DN78
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9796:LOC100059182
gene id: 9796:LOC100059182
uniprot id: A0A3Q2IID6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9796:FOXP1
gene id: 9796:FOXP1
uniprot id: A0A3Q2GZ26
uniprot id: F6X5A7
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100068519
gene id: 9796:LOC100068519
uniprot id: F6W803
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:STARD8
gene id: 9796:STARD8
uniprot id: F7ADU9
names: Subcellular Location Annotation
messages: Cytoplasm

9796:DDIT3
gene id: 9796:DDIT3
uniprot id: F7DZI6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9796:SLC25A24
gene id: 9796:SLC25A24
uniprot id: F6Z4N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9796:TRAP1
gene id: 9796:TRAP1
uniprot id: A0A3Q2HWR4
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9796:LY5
gene id: 9796:LY5
uniprot id: F6T5S3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:PSMC2
gene id: 9796:PSMC2
uniprot id: F6YWS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9796:DUSP10
gene id: 9796:DUSP10
uniprot id: F6S237
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9796:MTX2
gene id: 9796:MTX2
uniprot id: F7BK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9796:HPX
gene id: 9796:HPX
uniprot id: F6X1I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

9796:CALB1
gene id: 9796:CALB1
uniprot id: F7D4N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

9796:LOC100071438
gene id: 9796:LOC100071438
uniprot id: F6Y447
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CHL1
gene id: 9796:CHL1
uniprot id: A0A3Q2I4G5
uniprot id: A0A3Q2IJM1
uniprot id: F6QXE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9796:GJB5
gene id: 9796:GJB5
uniprot id: F6RSJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:LOC100146678
gene id: 9796:LOC100146678
uniprot id: F6X172
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DYNC1I2
gene id: 9796:DYNC1I2
uniprot id: F6WDD0
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9796:LOC100051878
gene id: 9796:LOC100051878
uniprot id: F7B5B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9796:IGFBP6
gene id: 9796:IGFBP6
uniprot id: F7DEB1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:ZSCAN25
gene id: 9796:ZSCAN25
uniprot id: F7E2K6
names: Subcellular Location Annotation
messages: Nucleus

9796:LIN7C
gene id: 9796:LIN7C
uniprot id: F6VRM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9796:NUTF2
gene id: 9796:NUTF2
uniprot id: F6XJB0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9796:STAC
gene id: 9796:STAC
uniprot id: F6TFM8
names: Subcellular Location Annotation
messages: sarcolemma

9796:RBP5
gene id: 9796:RBP5
uniprot id: F7DWR8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9796:SLC16A3
gene id: 9796:SLC16A3
uniprot id: A5JST7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9796:RPS25
gene id: 9796:RPS25
uniprot id: F6TXZ9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

9796:CD244
gene id: 9796:CD244
uniprot id: F7B7X4
names: Subcellular Location Annotation
messages: Membrane

9796:CASR
gene id: 9796:CASR
uniprot id: F6SIB8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:GDAP2
gene id: 9796:GDAP2
uniprot id: F7CCH4
names: Similarity
messages: Belongs to the GDAP2 family.

9796:MTERF3
gene id: 9796:MTERF3
uniprot id: F6RJ14
names: Similarity
messages: Belongs to the mTERF family.

9796:SIRT4
gene id: 9796:SIRT4
uniprot id: F7AG27
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

9796:WBP4
gene id: 9796:WBP4
uniprot id: F6VHH0
names: Subcellular Location Annotation
messages: Nucleus

9796:DIAPH3
gene id: 9796:DIAPH3
uniprot id: A0A3Q2HP41
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

9796:RGS4
gene id: 9796:RGS4
uniprot id: F7AWM3
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9796:VIRMA
gene id: 9796:VIRMA
uniprot id: A0A3Q2HG25
uniprot id: F6R0Z7
names: Similarity
messages: Belongs to the vir family.

9796:GLOD4
gene id: 9796:GLOD4
uniprot id: F6Z1U4
names: Similarity
messages: Belongs to the glyoxalase I family.

9796:LOC100061882
gene id: 9796:LOC100061882
uniprot id: F6YJ50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ACKR3
gene id: 9796:ACKR3
uniprot id: F7D7T0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:TRAPPC1
gene id: 9796:TRAPPC1
uniprot id: F7AL43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9796:TIMM22
gene id: 9796:TIMM22
uniprot id: F6Y1N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9796:TAC1
gene id: 9796:TAC1
uniprot id: A0A3Q2KWQ8
uniprot id: A0A5F5PYB9
uniprot id: F6X7J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9796:TGFB2
gene id: 9796:TGFB2
uniprot id: F6WJJ3
uniprot id: F6YX31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9796:TGM1
gene id: 9796:TGM1
uniprot id: F6PW39
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9796:KIF11
gene id: 9796:KIF11
uniprot id: F7DF61
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:CCNT1
gene id: 9796:CCNT1
uniprot id: Q9XT26
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylation on serine residues by PARP1 in response to DNA damage disrupts the phase separation activity of CCNT1, thereby preventing activation of CDK9.
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with BRD4, targets chromatin binding. Interacts with JMJD6. Interacts with MDFIC. Interacts with HSF1. Interacts with HTATSF1. Interacts with TBX21.
messages: Nucleus
messages: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II.
messages: The histidine-rich domain (HRD) region is intrinsically disordered and promotes the formation of phase-separated liquid droplets that enhance binding of the P-TEFb complex to the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).

9796:NOL6
gene id: 9796:NOL6
uniprot id: A0A3Q2H7T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

9796:HCRT
gene id: 9796:HCRT
uniprot id: F6TU74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

9796:EXOSC9
gene id: 9796:EXOSC9
uniprot id: F6RLU8
names: Subcellular Location Annotation
messages: Cytoplasm

9796:LOC102149570
gene id: 9796:LOC102149570
uniprot id: A0A3Q2GYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tigger transposable element derived protein family.
messages: Nucleus

9796:SUCLA2
gene id: 9796:SUCLA2
uniprot id: F6ZY52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9796:CDK2AP2
gene id: 9796:CDK2AP2
uniprot id: F7CR29
names: Similarity
messages: Belongs to the CDK2AP family.

9796:POR
gene id: 9796:POR
uniprot id: B1PL89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9796:CNTFR
gene id: 9796:CNTFR
uniprot id: F7ACW5
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9796:EIF2B1
gene id: 9796:EIF2B1
uniprot id: F6R6B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9796:SULT2A1
gene id: 9796:SULT2A1
uniprot id: D9IPW3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:RIPK2
gene id: 9796:RIPK2
uniprot id: A0A3Q2GV29
uniprot id: A0A3Q2HFQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.

9796:ELF2
gene id: 9796:ELF2
uniprot id: F6X830
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:GRB7
gene id: 9796:GRB7
uniprot id: F6Q2Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9796:EXTL2
gene id: 9796:EXTL2
uniprot id: A0A3Q2HTR4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:LOC100057334
gene id: 9796:LOC100057334
uniprot id: F7AT54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:S100A9
gene id: 9796:S100A9
uniprot id: F6T046
names: Similarity
messages: Belongs to the S-100 family.

9796:IMMT
gene id: 9796:IMMT
uniprot id: A0A3Q2GV85
uniprot id: F6R6I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9796:UTP6
gene id: 9796:UTP6
uniprot id: F7AXG5
names: Similarity
messages: Belongs to the UTP6 family.

9796:HACL1
gene id: 9796:HACL1
uniprot id: F6WII8
names: Similarity
messages: Belongs to the TPP enzyme family.

9796:ADRA1A
gene id: 9796:ADRA1A
uniprot id: A0A3Q2HHL6
uniprot id: F6UTQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9796:FAM212A
gene id: 9796:FAM212A
uniprot id: F6T7P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9796:LOC100061127
gene id: 9796:LOC100061127
uniprot id: A0A3Q2GUZ4
names: Similarity
messages: Belongs to the MHC class II family.

9796:ANAPC11
gene id: 9796:ANAPC11
uniprot id: F7C530
names: Similarity
messages: Belongs to the RING-box family.

9796:RBX1
gene id: 9796:RBX1
uniprot id: A0A3Q2H592
names: Similarity
messages: Belongs to the RING-box family.

9796:C14H5orf24
gene id: 9796:C14H5orf24
uniprot id: A0A3Q2LG91
names: Similarity
messages: Belongs to the UPF0461 family.

9796:TRIQK
gene id: 9796:TRIQK
uniprot id: A0A3Q2HHL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:EHF
gene id: 9796:EHF
uniprot id: A0A3Q2HVS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:CDCA8
gene id: 9796:CDCA8
uniprot id: F6TAI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9796:MMP27
gene id: 9796:MMP27
uniprot id: F6UI50
names: Similarity
messages: Belongs to the peptidase M10A family.

9796:LOC102147636
gene id: 9796:LOC102147636
uniprot id: F6W5J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CLDN16
gene id: 9796:CLDN16
uniprot id: F6XTZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:BCL2L1
gene id: 9796:BCL2L1
uniprot id: A0A3Q2H0F6
uniprot id: F6WQI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9796:MYC
gene id: 9796:MYC
uniprot id: A0A3Q2I924
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.
messages: nucleolus
messages: nucleoplasm

9796:KCNE2
gene id: 9796:KCNE2
uniprot id: A0A5F5PS77
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9796:FAM118B
gene id: 9796:FAM118B
uniprot id: F7A4Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

9796:B4GALT4
gene id: 9796:B4GALT4
uniprot id: F7B8Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9796:LOC100071756
gene id: 9796:LOC100071756
uniprot id: F7B6F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GNB2
gene id: 9796:GNB2
uniprot id: F6WQ61
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9796:EQUCABV1R924
gene id: 9796:EQUCABV1R924
uniprot id: A0A3Q2GS82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:PHKG1
gene id: 9796:PHKG1
uniprot id: F6U196
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9796:PRPS1L1
gene id: 9796:PRPS1L1
uniprot id: F6TAG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9796:LOC100629205
gene id: 9796:LOC100629205
uniprot id: A0A3Q2I071
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100059515
gene id: 9796:LOC100059515
uniprot id: F6WV74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DOCK8
gene id: 9796:DOCK8
uniprot id: A0A3Q2KRH1
names: Similarity
messages: Belongs to the DOCK family.

9796:VPS36
gene id: 9796:VPS36
uniprot id: K9K218
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9796:HMOX2
gene id: 9796:HMOX2
uniprot id: F6Z702
names: Similarity
messages: Belongs to the heme oxygenase family.

9796:STK17B
gene id: 9796:STK17B
uniprot id: A0A3Q2GXD2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:ADGRG7
gene id: 9796:ADGRG7
uniprot id: F6YF06
names: Subcellular Location Annotation
messages: Membrane

9796:GJB1
gene id: 9796:GJB1
uniprot id: A0A654ICR5
uniprot id: Q6WGK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:TMED5
gene id: 9796:TMED5
uniprot id: F6XCR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with TMED9 and TMED10.
messages: Membrane
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.
messages: cis-Golgi network membrane

9796:KRR1
gene id: 9796:KRR1
uniprot id: F6SPC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9796:LOC100073120
gene id: 9796:LOC100073120
uniprot id: F6ZGI0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:LTF
gene id: 9796:LTF
uniprot id: F6XLB1
names: Similarity
messages: Belongs to the transferrin family.

9796:MIP
gene id: 9796:MIP
uniprot id: F6T7W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9796:TACR2
gene id: 9796:TACR2
uniprot id: A0A3Q2LP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:ARF2
gene id: 9796:ARF2
uniprot id: A0A3Q2IE61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9796:BBS7
gene id: 9796:BBS7
uniprot id: A0A3Q2H7W6
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9796:LOC100052105
gene id: 9796:LOC100052105
uniprot id: A0A3Q2GZN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9796:IFNG
gene id: 9796:IFNG
uniprot id: A0A7R8C3S7
uniprot id: P42160
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Released primarily from activated T lymphocytes.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9796:LOC100071761
gene id: 9796:LOC100071761
uniprot id: F7AE50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ATP2B4
gene id: 9796:ATP2B4
uniprot id: A0A3Q2HNP9
uniprot id: A0A3Q2LS25
uniprot id: F7B024
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:YIPF1
gene id: 9796:YIPF1
uniprot id: F7A1P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9796:EXT1
gene id: 9796:EXT1
uniprot id: F6TQG8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.
messages: Membrane
messages: cis-Golgi network membrane

9796:NUTM2F
gene id: 9796:NUTM2F
uniprot id: F6YCV2
names: Similarity
messages: Belongs to the NUT family.

9796:TAT
gene id: 9796:TAT
uniprot id: F6YST0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9796:LOC100054896
gene id: 9796:LOC100054896
uniprot id: A0A3Q2I2W9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CRBN
gene id: 9796:CRBN
uniprot id: A0A3Q2IC00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9796:PCMTD1
gene id: 9796:PCMTD1
uniprot id: F6WHD4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9796:EIF4ENIF1
gene id: 9796:EIF4ENIF1
uniprot id: A0A3Q2H0T8
names: Subcellular Location Annotation
messages: Cytoplasm

9796:LOC100071974
gene id: 9796:LOC100071974
uniprot id: A0A3Q2HC98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PAM
gene id: 9796:PAM
uniprot id: Q28390
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9796:FABP2
gene id: 9796:FABP2
uniprot id: Q673L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9796:LOC100072171
gene id: 9796:LOC100072171
uniprot id: F6Z787
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SAR1B
gene id: 9796:SAR1B
uniprot id: F6QPV3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9796:TOMM22
gene id: 9796:TOMM22
uniprot id: A0A3Q2LEX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9796:GUCY2C
gene id: 9796:GUCY2C
uniprot id: F7AV13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9796:DRA
gene id: 9796:DRA
uniprot id: K9MCF1
names: Similarity
messages: Belongs to the MHC class II family.

9796:TBX20
gene id: 9796:TBX20
uniprot id: F7CIF3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9796:TPPP3
gene id: 9796:TPPP3
uniprot id: F7CMU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: cytoskeleton

9796:RDX
gene id: 9796:RDX
uniprot id: A0A5F5PP99
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9796:SEC23A
gene id: 9796:SEC23A
uniprot id: A0A3Q2H5Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9796:LOC100061533
gene id: 9796:LOC100061533
uniprot id: A0A3Q2HMQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HARS
gene id: 9796:HARS
uniprot id: F6ZCG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9796:TMEM205
gene id: 9796:TMEM205
uniprot id: F7CLB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9796:PRKCG
gene id: 9796:PRKCG
uniprot id: F7CH66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane

9796:FAM208B
gene id: 9796:FAM208B
uniprot id: A0A3Q2HGT6
names: Similarity
messages: Belongs to the TASOR family.

9796:DHODH
gene id: 9796:DHODH
uniprot id: F7C5A0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9796:RBM3
gene id: 9796:RBM3
uniprot id: F6YEU3
names: Subcellular Location Annotation
messages: Cytoplasm

9796:FUNDC1
gene id: 9796:FUNDC1
uniprot id: F6U1Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9796:CYCS
gene id: 9796:CYCS
uniprot id: F7D4V9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9796:TMEM173
gene id: 9796:TMEM173
uniprot id: F7AI13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9796:MTHFD1
gene id: 9796:MTHFD1
uniprot id: F6YIU8
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9796:IRAK4
gene id: 9796:IRAK4
uniprot id: F7BZX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9796:LY49C
gene id: 9796:LY49C
uniprot id: Q75XR9
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100067649
gene id: 9796:LOC100067649
uniprot id: A0A3Q2I1X0
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9796:HTR1E
gene id: 9796:HTR1E
uniprot id: F6YL63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:KRT20
gene id: 9796:KRT20
uniprot id: F6T114
names: Similarity
messages: Belongs to the intermediate filament family.

9796:POLR1C
gene id: 9796:POLR1C
uniprot id: F7CQE0
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9796:PPM1G
gene id: 9796:PPM1G
uniprot id: F6Z8G6
names: Similarity
messages: Belongs to the PP2C family.

9796:PARP3
gene id: 9796:PARP3
uniprot id: F7BPU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9796:GAR1
gene id: 9796:GAR1
uniprot id: F7BNM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9796:TM4SF18
gene id: 9796:TM4SF18
uniprot id: A0A3Q2HL31
uniprot id: A0A3Q2ICI9
uniprot id: F7A0Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9796:TBCB
gene id: 9796:TBCB
uniprot id: F6UNW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

9796:LOC100070651
gene id: 9796:LOC100070651
uniprot id: F7B6T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ZNF330
gene id: 9796:ZNF330
uniprot id: F7DJQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

9796:BBS2
gene id: 9796:BBS2
uniprot id: F6PM46
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9796:SAT1
gene id: 9796:SAT1
uniprot id: F6X9A1
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Homodimer.

9796:ZNF622
gene id: 9796:ZNF622
uniprot id: F7E4N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9796:UBE2N
gene id: 9796:UBE2N
uniprot id: F6ZNY8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9796:LOC100062763
gene id: 9796:LOC100062763
uniprot id: F6VLY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:IL12A
gene id: 9796:IL12A
uniprot id: F6SRN5
uniprot id: Q9XSQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12. Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

9796:MVP
gene id: 9796:MVP
uniprot id: F6Q698
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9796:ANAPC15
gene id: 9796:ANAPC15
uniprot id: F6VWZ3
names: Similarity
messages: Belongs to the APC15 family.

9796:PKIG
gene id: 9796:PKIG
uniprot id: F7CQ12
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9796:BAK1
gene id: 9796:BAK1
uniprot id: F6XWS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9796:LOC100067701
gene id: 9796:LOC100067701
uniprot id: F6TQ35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ALDH8A1
gene id: 9796:ALDH8A1
uniprot id: F6Y7A5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9796:PCSK2
gene id: 9796:PCSK2
uniprot id: F6W2D5
names: Similarity
messages: Belongs to the peptidase S8 family.

9796:IGF2BP1
gene id: 9796:IGF2BP1
uniprot id: F6RV24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9796:SLC7A8
gene id: 9796:SLC7A8
uniprot id: A0A5F5PP90
uniprot id: F6ZQE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9796:UGP2
gene id: 9796:UGP2
uniprot id: A0A3Q2I375
uniprot id: F6Y4I1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9796:NSA2
gene id: 9796:NSA2
uniprot id: F7AN99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9796:TGFB1
gene id: 9796:TGFB1
uniprot id: O19011
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction.
messages: Homodimer; disulfide-linked. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling and the HTRA protease activity is required for this inhibition. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with CD109, DPT and ASPN. Interacts with EFEMP2. Interacts with TSKU; the interaction contributes to regulation of the hair cycle.
messages: Homodimer; disulfide-linked. Interacts with transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains TGF-beta-1 in a latent state; each latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Interacts with LTBP1; leading to regulation of TGF-beta-1 activation. Interacts with LRRC32/GARP; leading to regulation of TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Interacts with LRRC33/NRROS; leading to regulation of TGF-beta-1 activation in macrophages and microglia. Interacts (via cell attachment site) with integrins ITGAV and ITGB6 (ITGAV:ITGB6), leading to release of the active TGF-beta-1. Latency-associated peptide: Interacts with NREP; the interaction results in a decrease in TGFB1 autoinduction. Interacts with HSP90AB1; inhibits latent TGFB1 activation.
messages: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'. Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 ce…
messages: N-glycosylated. Deglycosylation leads to activation of Transforming growth factor beta-1 (TGF-beta-1); mechanisms triggering deglycosylation-driven activation of TGF-beta-1 are however unclear.
messages: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.
messages: Secreted
messages: The 'straitjacket' and 'arm' domains encircle the Transforming growth factor beta-1 (TGF-beta-1) monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104.
messages: The cell attachment site motif mediates binding to integrins (ITGAV:ITGB6 or ITGAV:ITGB8). The motif locates to a long loop in the arm domain called the bowtie tail. Integrin-binding stabilizes an alternative conformation of the bowtie tail. Activation by integrin requires force application by the actin cytoskeleton, which is resisted by the 'milieu molecules' (such as LTBP1, LRRC32/GARP and/or LRRC33/NRROS), resulting in distortion of the prodomain and release of the active TGF-beta-1.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
messages: extracellular matrix

9796:CES3
gene id: 9796:CES3
uniprot id: A0A3Q2HQC5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9796:ZDHHC16
gene id: 9796:ZDHHC16
uniprot id: A0A3Q2GU14
uniprot id: A0A3Q2HVM6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9796:NDST4
gene id: 9796:NDST4
uniprot id: A0A3Q2HV39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9796:LOC100053322
gene id: 9796:LOC100053322
uniprot id: F7C3U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ALOX5AP
gene id: 9796:ALOX5AP
uniprot id: A0A3Q2HEW0
uniprot id: A0A3Q2HTJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:CDC42
gene id: 9796:CDC42
uniprot id: K9K202
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: centrosome

9796:BCKDK
gene id: 9796:BCKDK
uniprot id: A0A3Q2GSP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9796:LOC100051914
gene id: 9796:LOC100051914
uniprot id: F7BVF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RPRD1B
gene id: 9796:RPRD1B
uniprot id: A0A3Q2HIY4
uniprot id: F6SLS3
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9796:CGA
gene id: 9796:CGA
uniprot id: A0A0F7RPW0
uniprot id: P01220
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9796:PPARA
gene id: 9796:PPARA
uniprot id: F7DSM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
messages: Nucleus

9796:LOC100147227
gene id: 9796:LOC100147227
uniprot id: F6V0X8
names: Similarity
messages: Belongs to the FAM47 family.

9796:ATG9B
gene id: 9796:ATG9B
uniprot id: F7BL31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9796:PAX7
gene id: 9796:PAX7
uniprot id: A0A5K1UQD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9796:CALCA
gene id: 9796:CALCA
uniprot id: Q9N0T2
uniprot id: Q9N0V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity).
messages: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
messages: Secreted

9796:UGT2A2
gene id: 9796:UGT2A2
uniprot id: A0A3Q2IG22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9796:TNFSF14
gene id: 9796:TNFSF14
uniprot id: F6SZH4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9796:PIGG
gene id: 9796:PIGG
uniprot id: A0A3Q2LB38
uniprot id: A0A3Q2LE92
uniprot id: F6T8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:SLCO1B3
gene id: 9796:SLCO1B3
uniprot id: A0A0E8PL88
uniprot id: F6SUK0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:LOC100057940
gene id: 9796:LOC100057940
uniprot id: A0A3Q2HUE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ZSCAN9
gene id: 9796:ZSCAN9
uniprot id: F7CA80
names: Subcellular Location Annotation
messages: Nucleus

9796:APOM
gene id: 9796:APOM
uniprot id: F6UEG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9796:GPAT2
gene id: 9796:GPAT2
uniprot id: F7C287
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

9796:CLN3
gene id: 9796:CLN3
uniprot id: F6R2F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

9796:AGXT
gene id: 9796:AGXT
uniprot id: F6VWR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisome

9796:LOC102147612
gene id: 9796:LOC102147612
uniprot id: A0A3Q2H4V1
names: Subcellular Location Annotation
messages: Nucleus

9796:CNR2
gene id: 9796:CNR2
uniprot id: F7CUS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:FAR2
gene id: 9796:FAR2
uniprot id: A0A3Q2HEK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9796:DDX53
gene id: 9796:DDX53
uniprot id: F7AAA3
names: Similarity
messages: Belongs to the DEAD box helicase family.

9796:LOC100051901
gene id: 9796:LOC100051901
uniprot id: F6YRE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9796:TAAR4
gene id: 9796:TAAR4
uniprot id: F7BPI5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:SCGB1C1
gene id: 9796:SCGB1C1
uniprot id: A0A5F5PND6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9796:TOR1AIP2
gene id: 9796:TOR1AIP2
uniprot id: F6U4U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9796:TRAK1
gene id: 9796:TRAK1
uniprot id: A0A5F5PNM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9796:SUPT20H
gene id: 9796:SUPT20H
uniprot id: A0A3Q2I4P8
uniprot id: F7DU55
names: Similarity
messages: Belongs to the SPT20 family.

9796:CD68
gene id: 9796:CD68
uniprot id: Q6UBQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9796:SEC23B
gene id: 9796:SEC23B
uniprot id: F6Q638
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9796:RAP2C
gene id: 9796:RAP2C
uniprot id: K9K4A9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9796:SLFN5
gene id: 9796:SLFN5
uniprot id: F6Z717
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9796:BORCS5
gene id: 9796:BORCS5
uniprot id: F6TND5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9796:PDE5A
gene id: 9796:PDE5A
uniprot id: F7CZ40
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9796:RPS15A
gene id: 9796:RPS15A
uniprot id: F7BLU1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.

9796:SLC39A1
gene id: 9796:SLC39A1
uniprot id: F6T5M8
names: Subcellular Location Annotation
messages: Membrane

9796:PTGES3
gene id: 9796:PTGES3
uniprot id: F6ZQ56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9796:LOC100070737
gene id: 9796:LOC100070737
uniprot id: F6QK41
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PPY
gene id: 9796:PPY
uniprot id: A0A5F5Q2D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
messages: Secreted

9796:LOC100629859
gene id: 9796:LOC100629859
uniprot id: A0A7R8GUY2
uniprot id: F6ZD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:EQUCABV1R928
gene id: 9796:EQUCABV1R928
uniprot id: A0A3Q2GX22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:SLC39A13
gene id: 9796:SLC39A13
uniprot id: F6QPE4
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100072447
gene id: 9796:LOC100072447
uniprot id: F7B192
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CFLAR
gene id: 9796:CFLAR
uniprot id: F6RFJ8
names: Similarity
messages: Belongs to the peptidase C14A family.

9796:PRRX1
gene id: 9796:PRRX1
uniprot id: A0A3Q2LDV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9796:DEFB126
gene id: 9796:DEFB126
uniprot id: F7BFE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9796:LANCL1
gene id: 9796:LANCL1
uniprot id: F6X0A7
names: Similarity
messages: Belongs to the LanC-like protein family.

9796:POU6F1
gene id: 9796:POU6F1
uniprot id: F6WRV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9796:TAX1BP3
gene id: 9796:TAX1BP3
uniprot id: F6WIC5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9796:PCSK5
gene id: 9796:PCSK5
uniprot id: A0A3Q2H267
uniprot id: A0A3Q2LAW7
uniprot id: F6VT99
names: Similarity
messages: Belongs to the peptidase S8 family.

9796:SCFD2
gene id: 9796:SCFD2
uniprot id: F6R8P0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9796:GNPAT
gene id: 9796:GNPAT
uniprot id: F7DJC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9796:FAM174A
gene id: 9796:FAM174A
uniprot id: A0A0D3QJ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9796:PRPF19
gene id: 9796:PRPF19
uniprot id: F7CE01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9796:ZMPSTE24
gene id: 9796:ZMPSTE24
uniprot id: F6WEU3
uniprot id: K9KEX5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9796:CPA4
gene id: 9796:CPA4
uniprot id: F7BP09
names: Similarity
messages: Belongs to the peptidase M14 family.

9796:LOC100147174
gene id: 9796:LOC100147174
uniprot id: A0A5F5PQR3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family.
messages: Monomer.
messages: Secreted

9796:GOT2
gene id: 9796:GOT2
uniprot id: F6YXZ8
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9796:DRD3
gene id: 9796:DRD3
uniprot id: A0A3Q2I4H7
uniprot id: F6X207
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9796:LOC100629823
gene id: 9796:LOC100629823
uniprot id: F6PR72
names: Subcellular Location Annotation
messages: Secreted

9796:DERL2
gene id: 9796:DERL2
uniprot id: A0A3Q2I2B6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:NDUFS7
gene id: 9796:NDUFS7
uniprot id: F7D489
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

9796:ENO1
gene id: 9796:ENO1
uniprot id: I3RM62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9796:RHAG
gene id: 9796:RHAG
uniprot id: F6T1H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9796:ACTR1B
gene id: 9796:ACTR1B
uniprot id: A0A3Q2GZP6
names: Similarity
messages: Belongs to the actin family.

9796:GUCY2F
gene id: 9796:GUCY2F
uniprot id: F6ZZC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9796:LOC100067658
gene id: 9796:LOC100067658
uniprot id: F6UDU3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GJC3
gene id: 9796:GJC3
uniprot id: F6Z9W1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: gap junction

9796:LOC100072086
gene id: 9796:LOC100072086
uniprot id: F6U7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100057471
gene id: 9796:LOC100057471
uniprot id: F6QBF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CFAP206
gene id: 9796:CFAP206
uniprot id: A0A3Q2L722
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme
messages: cilium basal body

9796:GDF3
gene id: 9796:GDF3
uniprot id: F6YWM3
names: Similarity
messages: Belongs to the TGF-beta family.

9796:PITX3
gene id: 9796:PITX3
uniprot id: F6YU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9796:BRS3
gene id: 9796:BRS3
uniprot id: F6TFU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9796:LOC100147487
gene id: 9796:LOC100147487
uniprot id: F7B394
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NME6
gene id: 9796:NME6
uniprot id: A0A3Q2LC87
names: Similarity
messages: Belongs to the NDK family.

9796:IFND2
gene id: 9796:IFND2
uniprot id: B6CGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:ANKRD34B
gene id: 9796:ANKRD34B
uniprot id: F6PK04
names: Similarity
messages: Belongs to the ANKRD34 family.

9796:LOC100058903
gene id: 9796:LOC100058903
uniprot id: F6QKB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CUL7
gene id: 9796:CUL7
uniprot id: F6WY43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9796:HSD3B7
gene id: 9796:HSD3B7
uniprot id: F7BI80
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9796:LOC100068140
gene id: 9796:LOC100068140
uniprot id: A0A3Q2HS62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RNASE12
gene id: 9796:RNASE12
uniprot id: F6TMR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9796:LOC100629841
gene id: 9796:LOC100629841
uniprot id: F6SN30
names: Subcellular Location Annotation
messages: Secreted

9796:CLNS1A
gene id: 9796:CLNS1A
uniprot id: F7DS36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9796:TAP1
gene id: 9796:TAP1
uniprot id: F6TVN9
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9796:AKR1A1
gene id: 9796:AKR1A1
uniprot id: K9K2L1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9796:EMP1
gene id: 9796:EMP1
uniprot id: A0A3Q2HPS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9796:LOC100630193
gene id: 9796:LOC100630193
uniprot id: F6VLA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100062654
gene id: 9796:LOC100062654
uniprot id: A0A3Q2HRQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RRP1
gene id: 9796:RRP1
uniprot id: A0A3Q2I1F4
names: Similarity
messages: Belongs to the RRP1 family.

9796:CD5L
gene id: 9796:CD5L
uniprot id: F7BXD8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:ACTRT1
gene id: 9796:ACTRT1
uniprot id: F6WN44
names: Similarity
messages: Belongs to the actin family.

9796:SELP
gene id: 9796:SELP
uniprot id: F7BMP6
uniprot id: L7MSM7
uniprot id: Q5J3Q6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:CAMK2G
gene id: 9796:CAMK2G
uniprot id: A0A3Q2ID69
uniprot id: A0A3Q2ILE3
uniprot id: A0A3Q2L898
uniprot id: F6TEC0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9796:FIS1
gene id: 9796:FIS1
uniprot id: A0A3Q2H7N6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

9796:NARFL
gene id: 9796:NARFL
uniprot id: F6V0R3
names: Similarity
messages: Belongs to the NARF family.

9796:POLR2I
gene id: 9796:POLR2I
uniprot id: F6ZTX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9796:PPARG
gene id: 9796:PPARG
uniprot id: A0A3Q2HVR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9796:CHD2
gene id: 9796:CHD2
uniprot id: F6Y8P1
names: Subcellular Location Annotation
messages: Nucleus

9796:POLR2F
gene id: 9796:POLR2F
uniprot id: A0A5F5PT01
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9796:MED30
gene id: 9796:MED30
uniprot id: F6YU86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9796:DUSP26
gene id: 9796:DUSP26
uniprot id: F7DRR6
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9796:MED23
gene id: 9796:MED23
uniprot id: F6SJ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

9796:CARMIL2
gene id: 9796:CARMIL2
uniprot id: F6QSM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9796:OTX2
gene id: 9796:OTX2
uniprot id: A0A3Q2HQQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9796:OLFM1
gene id: 9796:OLFM1
uniprot id: A0A3Q2GU19
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9796:SLBP2
gene id: 9796:SLBP2
uniprot id: I2C087
names: Similarity
messages: Belongs to the SLBP family.

9796:WISP3
gene id: 9796:WISP3
uniprot id: F7BDT2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:GFOD1
gene id: 9796:GFOD1
uniprot id: F6ZHY6
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9796:HSD17B12
gene id: 9796:HSD17B12
uniprot id: F6Q4Z8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:DOLK
gene id: 9796:DOLK
uniprot id: F6Y7J6
names: Similarity
messages: Belongs to the polyprenol kinase family.

9796:SLC17A3
gene id: 9796:SLC17A3
uniprot id: F6V7R5
names: Subcellular Location Annotation
messages: Membrane

9796:BLK
gene id: 9796:BLK
uniprot id: F7CU65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9796:LOC100067446
gene id: 9796:LOC100067446
uniprot id: F7CAX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9796:LOC100068750
gene id: 9796:LOC100068750
uniprot id: F7DNK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:IP6K3
gene id: 9796:IP6K3
uniprot id: F6YJJ0
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9796:CSTA
gene id: 9796:CSTA
uniprot id: F6YCC0
names: Similarity
messages: Belongs to the cystatin family.

9796:MSMP
gene id: 9796:MSMP
uniprot id: F6SVX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9796:GLA
gene id: 9796:GLA
uniprot id: F7B6D0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9796:CYP2E1
gene id: 9796:CYP2E1
uniprot id: A8WDL7
uniprot id: F7DJ72
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9796:SDHAF2
gene id: 9796:SDHAF2
uniprot id: F7CLU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9796:SUPT4H1
gene id: 9796:SUPT4H1
uniprot id: F6X649
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9796:GDF2
gene id: 9796:GDF2
uniprot id: F6RLP6
names: Similarity
messages: Belongs to the TGF-beta family.

9796:LOC100053913
gene id: 9796:LOC100053913
uniprot id: F6ZJ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FGF10
gene id: 9796:FGF10
uniprot id: F7CND4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9796:CXCL13
gene id: 9796:CXCL13
uniprot id: F6ZX45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9796:GOSR2
gene id: 9796:GOSR2
uniprot id: A0A3Q2KV03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9796:GRN
gene id: 9796:GRN
uniprot id: F7AB03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

9796:PTGES
gene id: 9796:PTGES
uniprot id: Q8HZJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAPEG family.
messages: Homotrimer.
messages: Membrane
messages: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
messages: perinuclear region

9796:MDM2
gene id: 9796:MDM2
uniprot id: A0A3Q2H2X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9796:HOXA10
gene id: 9796:HOXA10
uniprot id: F6RVJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9796:TTR
gene id: 9796:TTR
uniprot id: F6UL68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9796:MC3R
gene id: 9796:MC3R
uniprot id: F6SBB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9796:LOC100054056
gene id: 9796:LOC100054056
uniprot id: F7CX23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MB21D2
gene id: 9796:MB21D2
uniprot id: F6QNN7
names: Similarity
messages: Belongs to the mab-21 family.

9796:PHF5A
gene id: 9796:PHF5A
uniprot id: F6VHY1
names: Similarity
messages: Belongs to the PHF5 family.

9796:LOC100146413
gene id: 9796:LOC100146413
uniprot id: A0A3Q2HJW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:RPL10
gene id: 9796:RPL10
uniprot id: F7AYR2
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9796:CSF3
gene id: 9796:CSF3
uniprot id: Q8MKE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
messages: Secreted

9796:LUM
gene id: 9796:LUM
uniprot id: A2Q0Z2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

9796:DLGAP4
gene id: 9796:DLGAP4
uniprot id: F6T6X7
uniprot id: F6ZXF6
names: Similarity
messages: Belongs to the SAPAP family.

9796:DLX3
gene id: 9796:DLX3
uniprot id: F7DMX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9796:HSD17B11
gene id: 9796:HSD17B11
uniprot id: F6TBM0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:TRPV2
gene id: 9796:TRPV2
uniprot id: F7A622
names: Subcellular Location Annotation
messages: Membrane

9796:MRPL24
gene id: 9796:MRPL24
uniprot id: F7AKA4
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9796:ZUFSP
gene id: 9796:ZUFSP
uniprot id: F7AGN4
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9796:TMCC2
gene id: 9796:TMCC2
uniprot id: A0A5F5PU54
names: Similarity
messages: Belongs to the TEX28 family.

9796:ISY1
gene id: 9796:ISY1
uniprot id: F7AEY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9796:CPB2
gene id: 9796:CPB2
uniprot id: A0A5F5PLV2
names: Similarity
messages: Belongs to the peptidase M14 family.

9796:OSBPL7
gene id: 9796:OSBPL7
uniprot id: F6VMB7
names: Similarity
messages: Belongs to the OSBP family.

9796:KEF40 p11
gene id: 9796:KEF40_p11
uniprot id: A5JYA3
uniprot id: P48659
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9796:RBBP5
gene id: 9796:RBBP5
uniprot id: F6VVI8
names: Subcellular Location Annotation
messages: Nucleus

9796:PDHB
gene id: 9796:PDHB
uniprot id: F7A900
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9796:ZNF830
gene id: 9796:ZNF830
uniprot id: F6Y5B4
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus speckle

9796:ATP5IF1
gene id: 9796:ATP5IF1
uniprot id: F6ZXT0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9796:CDH8
gene id: 9796:CDH8
uniprot id: A0A5F5PYD5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9796:EDEM3
gene id: 9796:EDEM3
uniprot id: F6ZG02
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9796:LYRM2
gene id: 9796:LYRM2
uniprot id: F6QST0
names: Similarity
messages: Belongs to the complex I LYR family.

9796:ACHE
gene id: 9796:ACHE
uniprot id: F7DYJ5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9796:RND3
gene id: 9796:RND3
uniprot id: F6S6C2
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9796:LOC100630846
gene id: 9796:LOC100630846
uniprot id: A0A3Q2GV49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9796:ANXA4
gene id: 9796:ANXA4
uniprot id: F6S9R7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

9796:LOC100069245
gene id: 9796:LOC100069245
uniprot id: F6V8Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SLC39A9
gene id: 9796:SLC39A9
uniprot id: F7E492
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

9796:MSMB
gene id: 9796:MSMB
uniprot id: A0A5F5PL59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9796:LBH
gene id: 9796:LBH
uniprot id: F7D4C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9796:GLRA3
gene id: 9796:GLRA3
uniprot id: A0A5F5PZC8
uniprot id: F6YBB6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9796:ATG12
gene id: 9796:ATG12
uniprot id: F6SRW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9796:SYNE1
gene id: 9796:SYNE1
uniprot id: F6RHE9
names: Similarity
messages: Belongs to the nesprin family.

9796:CDX4
gene id: 9796:CDX4
uniprot id: A0A3Q2I356
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9796:TGM7
gene id: 9796:TGM7
uniprot id: F7D4E7
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9796:RCAN1
gene id: 9796:RCAN1
uniprot id: F7C0K2
names: Similarity
messages: Belongs to the RCAN family.

9796:HOXB13
gene id: 9796:HOXB13
uniprot id: F6ZTG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9796:ZCCHC8
gene id: 9796:ZCCHC8
uniprot id: F7CGX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

9796:INHA
gene id: 9796:INHA
uniprot id: F6UTU7
uniprot id: P55101
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein.
messages: Secreted

9796:FAN1
gene id: 9796:FAN1
uniprot id: A0A3Q2GUU8
uniprot id: A0A5F5PLV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

9796:SEMA7A
gene id: 9796:SEMA7A
uniprot id: F7C7V8
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:DOLPP1
gene id: 9796:DOLPP1
uniprot id: F7CBS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9796:PSMB7
gene id: 9796:PSMB7
uniprot id: F7CUX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9796:CNRIP1
gene id: 9796:CNRIP1
uniprot id: A0A3Q2I0U1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9796:PNO1
gene id: 9796:PNO1
uniprot id: F7AF47
names: Similarity
messages: Belongs to the PNO1 family.

9796:PLSCR3
gene id: 9796:PLSCR3
uniprot id: F6U0G2
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9796:LOC100065079
gene id: 9796:LOC100065079
uniprot id: F7E0U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GPBP1L1
gene id: 9796:GPBP1L1
uniprot id: A0A3Q2HWI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9796:SPECC1L
gene id: 9796:SPECC1L
uniprot id: A0A5F5PGL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9796:LOC100051301
gene id: 9796:LOC100051301
uniprot id: A0A3Q2HT63
names: Similarity
messages: Belongs to the serpin family.

9796:LOC100071061
gene id: 9796:LOC100071061
uniprot id: A0A3Q2H4N0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9796:LOC100063056
gene id: 9796:LOC100063056
uniprot id: A0A3Q2H1B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:AVPI1
gene id: 9796:AVPI1
uniprot id: F6T5T7
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9796:TMEM218
gene id: 9796:TMEM218
uniprot id: F6ZA06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9796:MAP3K7
gene id: 9796:MAP3K7
uniprot id: F7BAU3
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9796:WASHC5
gene id: 9796:WASHC5
uniprot id: A0A3Q2H5H4
uniprot id: F6RQ92
names: Similarity
messages: Belongs to the strumpellin family.

9796:COG4
gene id: 9796:COG4
uniprot id: F7D287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9796:EMC4
gene id: 9796:EMC4
uniprot id: F6QM30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:SPC24
gene id: 9796:SPC24
uniprot id: F6SZX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9796:GRM3
gene id: 9796:GRM3
uniprot id: F6T9I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9796:EMC7
gene id: 9796:EMC7
uniprot id: F7AME9
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

9796:ENPP4
gene id: 9796:ENPP4
uniprot id: F6RYF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

9796:ADAMTS4
gene id: 9796:ADAMTS4
uniprot id: A8HDQ3
uniprot id: Q95N24
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9796:PSMC3
gene id: 9796:PSMC3
uniprot id: F6R449
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9796:CSN2
gene id: 9796:CSN2
uniprot id: Q9GKK3
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Accounts for 4% of total casein.
messages: Belongs to the beta-casein family.
messages: Important role in determination of the surface properties of the casein micelles.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted
messages: Spontaneous deamidation of Asn-150 produces aspartate or isoaspartate.
messages: There are at least five different forms found in milk, with varying degrees of phosphorylation. These include form 3-P which is phosphorylated at three sites that have not been determined, this form is present in very low amounts, form 4-P which is phosphorylated at four sites, form 5-P which is phosphorylated at five sites, form 6-P which is phosphorylated at six sites, and form 7-P which is phosphorylated at seven sites.

9796:LOC100054146
gene id: 9796:LOC100054146
uniprot id: F7CRV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:NACC2
gene id: 9796:NACC2
uniprot id: A0A5F5PF35
names: Subcellular Location Annotation
messages: Nucleus

9796:YIF1B
gene id: 9796:YIF1B
uniprot id: A0A3Q2I0F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9796:LOC100630758
gene id: 9796:LOC100630758
uniprot id: A0A3Q2KSW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9796:RPL23
gene id: 9796:RPL23
uniprot id: A0A3Q2LDJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9796:PSIP1
gene id: 9796:PSIP1
uniprot id: A1YAF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9796:TMEM106B
gene id: 9796:TMEM106B
uniprot id: F7C586
names: Similarity
messages: Belongs to the TMEM106 family.

9796:SF3B5
gene id: 9796:SF3B5
uniprot id: F6QIH9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9796:SDR9C7
gene id: 9796:SDR9C7
uniprot id: F6ZG36
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:LOC100051498
gene id: 9796:LOC100051498
uniprot id: F7DRB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CAD
gene id: 9796:CAD
uniprot id: A0A3Q2HXE5
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

9796:LOC100052031
gene id: 9796:LOC100052031
uniprot id: F7AAU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TMEM159
gene id: 9796:TMEM159
uniprot id: F6R1K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9796:KCNJ13
gene id: 9796:KCNJ13
uniprot id: F7CJ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9796:LOC100051214
gene id: 9796:LOC100051214
uniprot id: F6RJW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GANC
gene id: 9796:GANC
uniprot id: F6S9C5
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9796:TRAPPC6B
gene id: 9796:TRAPPC6B
uniprot id: F6ZQR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9796:LOC100058507
gene id: 9796:LOC100058507
uniprot id: F7C3K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FOXM1
gene id: 9796:FOXM1
uniprot id: A0A3Q2KSN4
uniprot id: F7A8S4
names: Subcellular Location Annotation
messages: Nucleus

9796:ADORA2B
gene id: 9796:ADORA2B
uniprot id: F6TXR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9796:SCN3B
gene id: 9796:SCN3B
uniprot id: A0A3Q2LA13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9796:SERPINB10
gene id: 9796:SERPINB10
uniprot id: B8K249
names: Similarity
messages: Belongs to the serpin family.

9796:SBDS
gene id: 9796:SBDS
uniprot id: F6VQ59
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9796:LOC100068729
gene id: 9796:LOC100068729
uniprot id: F7AK35
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9796:POLA2
gene id: 9796:POLA2
uniprot id: F6X9Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

9796:RRP12
gene id: 9796:RRP12
uniprot id: F7ANS3
names: Similarity
messages: Belongs to the RRP12 family.

9796:DTNA
gene id: 9796:DTNA
uniprot id: A0A3Q2GSU2
uniprot id: A0A3Q2H8Q0
uniprot id: A0A3Q2KW70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9796:FAM96A
gene id: 9796:FAM96A
uniprot id: A5YBL9
names: Similarity
messages: Belongs to the MIP18 family.

9796:EQUCABV1R919
gene id: 9796:EQUCABV1R919
uniprot id: F7CX76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:LOC102150493
gene id: 9796:LOC102150493
uniprot id: F6SYQ8
names: Subcellular Location Annotation
messages: Secreted

9796:JPT1
gene id: 9796:JPT1
uniprot id: A0A5F5PQK0
uniprot id: F7A978
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9796:TAS2R1
gene id: 9796:TAS2R1
uniprot id: F6PX49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9796:MCHR2
gene id: 9796:MCHR2
uniprot id: F6WED4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:DCTN2
gene id: 9796:DCTN2
uniprot id: A0A3Q2HP50
uniprot id: F7BSK7
names: Function
names: Similarity
messages: Belongs to the dynactin subunit 2 family.
messages: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

9796:GSDME
gene id: 9796:GSDME
uniprot id: Q7YS54
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Cleavage at Asp-270 by CASP3 (mature and uncleaved precursor forms) or granzyme B (GZMB) relieves autoinhibition and is sufficient to initiate pyroptosis.
messages: Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane.
messages: Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain, that is released upon cleavage by CASP3 or granzyme B (GZMB).
messages: Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively. After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukins (IL1B and IL16) and triggering pyroptosis. Binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Cleavage by CASP3 switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity. Cleavage by GZMB promotes tumor suppressor activity by triggering robust anti-tumor immunity. Suppresses tumors by mediating granzyme-mediated pyroptosis in target cells of natural killer (NK) cells: cleavage by granzyme B (GZMB), delivered to target cells from NK-cells, triggers pyroptosis of tumor cells and tumor suppression. May play a role in the p53/TP53-regulated cellular response to DNA damage.
messages: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis.
messages: Succination by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits processing by caspases, and ability to initiate pyroptosis. Succination modification is catalyzed by a non-enzymatic reaction caused by an accumulation of fumarate.
messages: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-E, N-terminal) following cleavage by CASP3 or granzyme B (GZMB). Activated by NLRP1 in the absence of GSDMD expression: NLRP1 cleaves and activates CASP8, promoting downstream activation of CASP3 and subsequent activation of GSDME.
messages: cytosol

9796:COX6A2
gene id: 9796:COX6A2
uniprot id: F7BMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9796:RPL9
gene id: 9796:RPL9
uniprot id: F6YIK2
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

9796:LOC100034005
gene id: 9796:LOC100034005
uniprot id: F7BAL2
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9796:GAL3ST4
gene id: 9796:GAL3ST4
uniprot id: F6QWJ0
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9796:TMEM106C
gene id: 9796:TMEM106C
uniprot id: F7C8L8
names: Similarity
messages: Belongs to the TMEM106 family.

9796:SMG9
gene id: 9796:SMG9
uniprot id: F7CLG6
names: Similarity
messages: Belongs to the SMG9 family.

9796:NARF
gene id: 9796:NARF
uniprot id: F6XAC9
names: Similarity
messages: Belongs to the NARF family.

9796:PEX16
gene id: 9796:PEX16
uniprot id: F6ZXH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9796:FAM219B
gene id: 9796:FAM219B
uniprot id: A0A3Q2HU51
names: Similarity
messages: Belongs to the FAM219 family.

9796:COX4I2
gene id: 9796:COX4I2
uniprot id: F7DTN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9796:ORMDL2
gene id: 9796:ORMDL2
uniprot id: F6VWW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9796:TLL2
gene id: 9796:TLL2
uniprot id: F7DMD5
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:CTU2
gene id: 9796:CTU2
uniprot id: F6W988
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTU2/NCS2 family.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9796:HGF
gene id: 9796:HGF
uniprot id: F6ZWI6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9796:LOC100630489
gene id: 9796:LOC100630489
uniprot id: F6RMK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9796:LOC100057630
gene id: 9796:LOC100057630
uniprot id: A0A3Q2HR31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DNAJC2
gene id: 9796:DNAJC2
uniprot id: A0A3Q2HAE9
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: cytosol

9796:POLR2G
gene id: 9796:POLR2G
uniprot id: F6RG40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

9796:ARL4D
gene id: 9796:ARL4D
uniprot id: F7CXK4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9796:RER1
gene id: 9796:RER1
uniprot id: F6R9T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9796:EQMCE1
gene id: 9796:EQMCE1
uniprot id: Q0R0B5
names: Similarity
messages: Belongs to the MHC class I family.

9796:BCHE
gene id: 9796:BCHE
uniprot id: Q9N1N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9796:EQUCABV1R930
gene id: 9796:EQUCABV1R930
uniprot id: A0A3Q2HJX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:ACSL6
gene id: 9796:ACSL6
uniprot id: A0A3Q2H6X6
uniprot id: A0A3Q2HFB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9796:SLC28A2
gene id: 9796:SLC28A2
uniprot id: F6Q3A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9796:MID1
gene id: 9796:MID1
uniprot id: F7CLC3
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

9796:SEPHS1
gene id: 9796:SEPHS1
uniprot id: F7CD67
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9796:IGF1
gene id: 9796:IGF1
uniprot id: A0A3Q2HFJ3
uniprot id: A0A5K1U714
uniprot id: A7LHD8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.
messages: Secreted

9796:SPACA4
gene id: 9796:SPACA4
uniprot id: F7CIL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9796:ANAPC5
gene id: 9796:ANAPC5
uniprot id: F6X4C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9796:APOA4
gene id: 9796:APOA4
uniprot id: F6RZ27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Extracellular vesicle
messages: Homotetramer. May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs. May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear. May interact with MAPT. May interact with MAP2. In the cerebrospinal fluid, interacts with secreted SORL1. Interacts with PMEL; this allows the loading of PMEL luminal fragment on ILVs to induce fibril nucleation.
messages: Vesicle
messages: extracellular matrix
messages: multivesicular body

9796:MRPL46
gene id: 9796:MRPL46
uniprot id: F7DHL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9796:FAM110B
gene id: 9796:FAM110B
uniprot id: F6QGA6
names: Similarity
messages: Belongs to the FAM110 family.

9796:CA4
gene id: 9796:CA4
uniprot id: F6UPK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Interacts with SLC4A4.
messages: Membrane

9796:COA3
gene id: 9796:COA3
uniprot id: F7CQ91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9796:REXO2
gene id: 9796:REXO2
uniprot id: F6ZER8
names: Similarity
messages: Belongs to the oligoribonuclease family.

9796:LOC100054300
gene id: 9796:LOC100054300
uniprot id: F6WBW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MED11
gene id: 9796:MED11
uniprot id: A0A5F5PLU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9796:MX1
gene id: 9796:MX1
uniprot id: F6QLQ9
uniprot id: Q28379
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By type I and type III interferons.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).
messages: ISGylated.
messages: Interferon-induced dynamin-like GTPase with antiviral activity.
messages: The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
messages: The middle domain mediates self-assembly and oligomerization.
messages: perinuclear region

9796:LOC100058073
gene id: 9796:LOC100058073
uniprot id: F7ACQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CLDN9
gene id: 9796:CLDN9
uniprot id: H9GZR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:RPL11
gene id: 9796:RPL11
uniprot id: F6UB53
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9796:BMP7
gene id: 9796:BMP7
uniprot id: E0A9E2
names: Similarity
messages: Belongs to the TGF-beta family.

9796:CIT
gene id: 9796:CIT
uniprot id: F6T1H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

9796:EIPR1
gene id: 9796:EIPR1
uniprot id: F7BHT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

9796:KRT73
gene id: 9796:KRT73
uniprot id: F7AGY4
names: Similarity
messages: Belongs to the intermediate filament family.

9796:AMZ2
gene id: 9796:AMZ2
uniprot id: F7BML9
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9796:LOC100061733
gene id: 9796:LOC100061733
uniprot id: F6VH52
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100072168
gene id: 9796:LOC100072168
uniprot id: F7BL61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:UCHL1
gene id: 9796:UCHL1
uniprot id: Q9GM50
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.
messages: Monomer. Homodimer. Interacts with COPS5 and SNCA (By similarity).
messages: O-glycosylated.
messages: The homodimer may have ATP-independent ubiquitin ligase activity. However, in another study, UCHL1 was shown to lack ubiquitin ligase activity.
messages: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity).

9796:SLC6A19
gene id: 9796:SLC6A19
uniprot id: A0A3Q2I8K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9796:ACTR10
gene id: 9796:ACTR10
uniprot id: A0A5F5PR33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9796:DSG3
gene id: 9796:DSG3
uniprot id: F6ZT82
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9796:NR4A2
gene id: 9796:NR4A2
uniprot id: A0A3Q2H5S3
uniprot id: F6ZRL4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9796:DHRS4
gene id: 9796:DHRS4
uniprot id: A0A5F5PW50
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:PSMA3
gene id: 9796:PSMA3
uniprot id: L7MS06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9796:ATG101
gene id: 9796:ATG101
uniprot id: F7B4H5
names: Similarity
messages: Belongs to the ATG101 family.

9796:TSPAN11
gene id: 9796:TSPAN11
uniprot id: F7BBY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9796:CTSW
gene id: 9796:CTSW
uniprot id: F6XVA3
names: Similarity
messages: Belongs to the peptidase C1 family.

9796:TMEM168
gene id: 9796:TMEM168
uniprot id: F6VHJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

9796:EIF4A1
gene id: 9796:EIF4A1
uniprot id: A0A5F5PKF3
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9796:SMIM8
gene id: 9796:SMIM8
uniprot id: A0A3Q2HD93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9796:GATA2
gene id: 9796:GATA2
uniprot id: A0A3Q2I432
names: Subcellular Location Annotation
messages: Nucleus

9796:TMEM135
gene id: 9796:TMEM135
uniprot id: F7BTJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane
messages: Peroxisome membrane

9796:RPS13
gene id: 9796:RPS13
uniprot id: F7DS56
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9796:TP63
gene id: 9796:TP63
uniprot id: A0A3Q2GTF8
uniprot id: A0A3Q2HNM1
uniprot id: A0A5F5PIN2
uniprot id: F7B2P6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9796:LIPG
gene id: 9796:LIPG
uniprot id: F6TN81
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:RMND1
gene id: 9796:RMND1
uniprot id: F6SKA3
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9796:LOC100054852
gene id: 9796:LOC100054852
uniprot id: F6WFH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9796:ATP8B4
gene id: 9796:ATP8B4
uniprot id: A0A3Q2H0I9
uniprot id: A0A3Q2I000
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9796:LOC100065752
gene id: 9796:LOC100065752
uniprot id: F6XY78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9796:ERLIN2
gene id: 9796:ERLIN2
uniprot id: F6S8T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9796:EXOC1
gene id: 9796:EXOC1
uniprot id: A0A3Q2HK08
uniprot id: F6WL34
uniprot id: F6WL70
names: Similarity
messages: Belongs to the SEC3 family.

9796:OXCT1
gene id: 9796:OXCT1
uniprot id: H1ADS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Mitochondrion

9796:KCNF1
gene id: 9796:KCNF1
uniprot id: F7E016
names: Subcellular Location Annotation
messages: Membrane

9796:TNF
gene id: 9796:TNF
uniprot id: B1AB92
uniprot id: P29553
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9796:CSN3
gene id: 9796:CSN3
uniprot id: P82187
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9796:MCU
gene id: 9796:MCU
uniprot id: F7A3K4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9796:LOC100054113
gene id: 9796:LOC100054113
uniprot id: A0A5F5PKH1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:CCNG1
gene id: 9796:CCNG1
uniprot id: F7A3B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

9796:RPL37A
gene id: 9796:RPL37A
uniprot id: A0A3Q2HSG5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9796:RACK1
gene id: 9796:RACK1
uniprot id: F7AWX3
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

9796:BDKRB2
gene id: 9796:BDKRB2
uniprot id: F6QJ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9796:IL17A
gene id: 9796:IL17A
uniprot id: B3VH88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9796:HSP90AA1
gene id: 9796:HSP90AA1
uniprot id: Q9GKX7
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer. Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1. Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex. The closed form interacts (via the middle domain and TPR repeat-binding motif) with co-chaperone TSC1 (via C-terminus). Interacts with TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity. Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8. Interacts with KSR1. Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity. May interact with NWD1. Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity. Interacts with co-chaperone AHSA1 (phosphorylated on 'Tyr-223'); the interaction activates HSP90AA1 ATPase activity and results in the dissociation of TSC1 from HSP90AA1. Interacts with FLCN in the presence of FNIP1. Interacts with HSP70, STIP1 and PTGES3. Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase. Interacts with SGTA (via TPR repeats). Interacts with TTC1 (via TPR repeats). Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with HSF1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities. Inte…
messages: ISGylated.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state. Co-chaperone TSC1 promotes ATP binding and inhibits HSP90AA1 ATPase activity. Binding to phosphorylated AHSA1 promotes HSP90AA1 ATPase activity. Inhibited by geldanamycin, Ganetespib (STA-9090) and SNX-2112.
messages: Melanosome
messages: Mitochondrion
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes S…
messages: Nucleus
messages: S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
messages: Ubiquitinated via 'Lys-63'-linked polyubiquitination by HECTD1. Ubiquitination promotes translocation into the cytoplasm away from the membrane and secretory pathways.

9796:CNOT7
gene id: 9796:CNOT7
uniprot id: F7ARZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9796:SLC26A8
gene id: 9796:SLC26A8
uniprot id: F7CWT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9796:MTERF4
gene id: 9796:MTERF4
uniprot id: F7BMB4
names: Similarity
messages: Belongs to the mTERF family.

9796:TAMM41
gene id: 9796:TAMM41
uniprot id: F6ZT16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9796:CACNG1
gene id: 9796:CACNG1
uniprot id: F6Q9C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

9796:CKM
gene id: 9796:CKM
uniprot id: F7BR99
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9796:AOC3
gene id: 9796:AOC3
uniprot id: F6T7X3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9796:KIF3A
gene id: 9796:KIF3A
uniprot id: A0A5F5PSZ1
uniprot id: A0A5F5Q0J3
uniprot id: F6SR05
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:LIN7A
gene id: 9796:LIN7A
uniprot id: F6YJ71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9796:RBM42
gene id: 9796:RBM42
uniprot id: A0A5F5PY96
names: Similarity
messages: Belongs to the RRM RBM42 family.

9796:NUPR1
gene id: 9796:NUPR1
uniprot id: F7C0N3
names: Similarity
messages: Belongs to the NUPR family.

9796:LDHD
gene id: 9796:LDHD
uniprot id: F6QED3
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9796:RDH13
gene id: 9796:RDH13
uniprot id: F6VQ31
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:ADNP
gene id: 9796:ADNP
uniprot id: A0A5F5PIM3
names: Subcellular Location Annotation
messages: Nucleus

9796:FERMT1
gene id: 9796:FERMT1
uniprot id: F7DTI3
names: Similarity
messages: Belongs to the kindlin family.

9796:ALKAL1
gene id: 9796:ALKAL1
uniprot id: A0A3Q2H4U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9796:EXOC4
gene id: 9796:EXOC4
uniprot id: F6T155
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9796:LOC100071886
gene id: 9796:LOC100071886
uniprot id: F6TZX0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RDH5
gene id: 9796:RDH5
uniprot id: F7CLW5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:TMED9
gene id: 9796:TMED9
uniprot id: F6VM62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:LOC100068501
gene id: 9796:LOC100068501
uniprot id: F6WEI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:POLR3C
gene id: 9796:POLR3C
uniprot id: F6Y987
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9796:CMC2
gene id: 9796:CMC2
uniprot id: F7D1X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9796:PON1
gene id: 9796:PON1
uniprot id: F7DTV1
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9796:RNASE10
gene id: 9796:RNASE10
uniprot id: Q70IB3
uniprot id: W0UVF8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pancreatic ribonuclease family.
messages: Male-specific expression in proximal caput of the epididymis.
messages: Secreted
messages: Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).
messages: The N-terminus is blocked. Glycosylated (By similarity).

9796:LOC100058292
gene id: 9796:LOC100058292
uniprot id: A0A3Q2HWI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HTR4
gene id: 9796:HTR4
uniprot id: A0A3Q2I2F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

9796:ART5
gene id: 9796:ART5
uniprot id: F7C7K8
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9796:LOC100057095
gene id: 9796:LOC100057095
uniprot id: F6RDK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9796:LOC100054366
gene id: 9796:LOC100054366
uniprot id: A0A3Q2HPZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9796:SERPINB13
gene id: 9796:SERPINB13
uniprot id: A0A3Q2HSA5
names: Similarity
messages: Belongs to the serpin family.

9796:CYP2F1
gene id: 9796:CYP2F1
uniprot id: A0A3Q2H5D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane
messages: Microsome membrane

9796:CPA6
gene id: 9796:CPA6
uniprot id: F6ZC58
names: Similarity
messages: Belongs to the peptidase M14 family.

9796:CXXC5
gene id: 9796:CXXC5
uniprot id: F6XBC8
names: Subcellular Location Annotation
messages: Cytoplasm

9796:EIF4G3
gene id: 9796:EIF4G3
uniprot id: Q6RZX2
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9796:LOC100050361
gene id: 9796:LOC100050361
uniprot id: A0A5F5PM22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9796:LHX3
gene id: 9796:LHX3
uniprot id: F6YA23
names: Subcellular Location Annotation
messages: Nucleus

9796:SNAPIN
gene id: 9796:SNAPIN
uniprot id: F7C8M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9796:LOC102147820
gene id: 9796:LOC102147820
uniprot id: F6UL34
names: Subcellular Location Annotation
messages: Membrane

9796:KCNH5
gene id: 9796:KCNH5
uniprot id: F7C714
names: Subcellular Location Annotation
messages: Membrane

9796:CREB3L4
gene id: 9796:CREB3L4
uniprot id: F6QMI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:SLC25A51
gene id: 9796:SLC25A51
uniprot id: F6SBU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:NKAPL
gene id: 9796:NKAPL
uniprot id: F7B6T6
names: Similarity
messages: Belongs to the NKAP family.

9796:LOC102149380
gene id: 9796:LOC102149380
uniprot id: F7C0V8
names: Similarity
messages: Belongs to the serpin family.

9796:OLFML1
gene id: 9796:OLFML1
uniprot id: F6QLR9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:LOC100068121
gene id: 9796:LOC100068121
uniprot id: F6UQQ2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GJD2
gene id: 9796:GJD2
uniprot id: F7A2N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:GAD1
gene id: 9796:GAD1
uniprot id: F6ZIC0
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9796:CCNB3
gene id: 9796:CCNB3
uniprot id: K4Q4R0
names: Similarity
messages: Belongs to the cyclin family.

9796:STX19
gene id: 9796:STX19
uniprot id: F6UAH4
names: Similarity
messages: Belongs to the syntaxin family.

9796:EIF3I
gene id: 9796:EIF3I
uniprot id: A0A3Q2I6B9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9796:IL7
gene id: 9796:IL7
uniprot id: A0A5F5Q112
uniprot id: F6U832
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Interacts with IL7R and CSF2RG.
messages: Secreted

9796:S100A2
gene id: 9796:S100A2
uniprot id: A0A5F5PJL0
names: Similarity
messages: Belongs to the S-100 family.

9796:SLC12A9
gene id: 9796:SLC12A9
uniprot id: F7CII4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9796:STIM1
gene id: 9796:STIM1
uniprot id: F6TJL6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:SPATA20
gene id: 9796:SPATA20
uniprot id: F6W2S8
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

9796:ATP13A5
gene id: 9796:ATP13A5
uniprot id: F6SII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9796:DAP3
gene id: 9796:DAP3
uniprot id: K9KAQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

9796:SOD1
gene id: 9796:SOD1
uniprot id: D7PPM2
uniprot id: P00443
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.
messages: Nucleus
messages: Palmitoylation helps nuclear targeting and decreases catalytic activity.
messages: Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.

9796:NTSR1
gene id: 9796:NTSR1
uniprot id: F7BSR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:LOC100056062
gene id: 9796:LOC100056062
uniprot id: Q38RB8
names: Similarity
messages: Belongs to the MHC class I family.

9796:PRKAA1
gene id: 9796:PRKAA1
uniprot id: K9K2H2
uniprot id: Q2LGG0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9796:GPRC5D
gene id: 9796:GPRC5D
uniprot id: A0A3Q2IE57
uniprot id: F6TWK3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:IL23A
gene id: 9796:IL23A
uniprot id: B1AB86
uniprot id: Q64FU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. Interacts with IL23R; this interaction enables recruitment of IL12RB1.
messages: Secreted

9796:PRPS1
gene id: 9796:PRPS1
uniprot id: K9K4A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9796:ANAPC16
gene id: 9796:ANAPC16
uniprot id: F6W110
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9796:TMEM106A
gene id: 9796:TMEM106A
uniprot id: A0A3Q2HB50
names: Similarity
messages: Belongs to the TMEM106 family.

9796:MAP2K5
gene id: 9796:MAP2K5
uniprot id: A0A3Q2HJH1
uniprot id: A0A3Q2HX30
uniprot id: F7BQY5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:TES
gene id: 9796:TES
uniprot id: A0A3Q2IDJ3
uniprot id: Q2QLB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

9796:ADAMTS12
gene id: 9796:ADAMTS12
uniprot id: F6TW13
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9796:SLC17A2
gene id: 9796:SLC17A2
uniprot id: A0A3Q2IFA7
names: Subcellular Location Annotation
messages: Membrane

9796:TARS
gene id: 9796:TARS
uniprot id: F6S5E7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9796:INPP5D
gene id: 9796:INPP5D
uniprot id: F7BUY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane

9796:TAF8
gene id: 9796:TAF8
uniprot id: A0A3Q2H977
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9796:NLGN3
gene id: 9796:NLGN3
uniprot id: A0A3Q2HLW2
uniprot id: A0A3Q2HTM9
uniprot id: F6UIF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9796:HOXC6
gene id: 9796:HOXC6
uniprot id: A0A3Q2IBK8
uniprot id: F6Y566
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9796:MRPS11
gene id: 9796:MRPS11
uniprot id: F7BVG1
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9796:CALB2
gene id: 9796:CALB2
uniprot id: F6SH92
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9796:GPRC6A
gene id: 9796:GPRC6A
uniprot id: A0A3Q2I4I8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:MAGT1
gene id: 9796:MAGT1
uniprot id: F6WDA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:TSPAN12
gene id: 9796:TSPAN12
uniprot id: F6T296
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9796:LOC100629682
gene id: 9796:LOC100629682
uniprot id: F6UF44
names: Subcellular Location Annotation
messages: Secreted

9796:ENO2
gene id: 9796:ENO2
uniprot id: F7CIX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9796:CYB561A3
gene id: 9796:CYB561A3
uniprot id: A0A5F5PJV7
uniprot id: F6QAZ5
names: Subcellular Location Annotation
messages: Membrane

9796:TRIM2
gene id: 9796:TRIM2
uniprot id: F6T4K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9796:PJVK
gene id: 9796:PJVK
uniprot id: F7E1W4
names: Similarity
messages: Belongs to the gasdermin family.

9796:LOC100062521
gene id: 9796:LOC100062521
uniprot id: F6ULN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9796:HNF4A
gene id: 9796:HNF4A
uniprot id: A0A5F5PJZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9796:RBM8A
gene id: 9796:RBM8A
uniprot id: F6XEW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9796:LOC100061341
gene id: 9796:LOC100061341
uniprot id: F7CCD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9796:SEC61G
gene id: 9796:SEC61G
uniprot id: F6XB05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:NMNAT3
gene id: 9796:NMNAT3
uniprot id: F6WRJ5
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9796:ACOX1
gene id: 9796:ACOX1
uniprot id: A0A3Q2I9Y2
uniprot id: F6TRZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9796:LOC100066824
gene id: 9796:LOC100066824
uniprot id: F6V3L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100072182
gene id: 9796:LOC100072182
uniprot id: F7AY46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TOE1
gene id: 9796:TOE1
uniprot id: F6UV52
names: Similarity
messages: Belongs to the CAF1 family.

9796:ERG28
gene id: 9796:ERG28
uniprot id: F7C9C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:DKK1
gene id: 9796:DKK1
uniprot id: I1W670
names: Similarity
messages: Belongs to the dickkopf family.

9796:BMX
gene id: 9796:BMX
uniprot id: A0A3Q2H5T5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9796:MAGOH
gene id: 9796:MAGOH
uniprot id: F6T5G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9796:CPN1
gene id: 9796:CPN1
uniprot id: F6WZA8
names: Similarity
messages: Belongs to the peptidase M14 family.

9796:LOC100069973
gene id: 9796:LOC100069973
uniprot id: F6WXM7
names: Similarity
messages: Belongs to the TTC39 family.

9796:HKDC1
gene id: 9796:HKDC1
uniprot id: A0A3Q2HML6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9796:LOC100072592
gene id: 9796:LOC100072592
uniprot id: F6XLG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9796:CSN1S2
gene id: 9796:CSN1S2
uniprot id: A0A0C5DH76
uniprot id: D2KAS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Secreted

9796:CD53
gene id: 9796:CD53
uniprot id: F6ZTF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9796:ATP5F1E
gene id: 9796:ATP5F1E
uniprot id: F6SMY6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9796:LOC100146589
gene id: 9796:LOC100146589
uniprot id: F7B1M1
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

9796:JRK
gene id: 9796:JRK
uniprot id: F6ZFV2
names: Subcellular Location Annotation
messages: Nucleus

9796:IRX6
gene id: 9796:IRX6
uniprot id: F7CUY6
names: Subcellular Location Annotation
messages: Nucleus

9796:BCAT1
gene id: 9796:BCAT1
uniprot id: A0A3Q2H525
uniprot id: F6T9A6
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9796:STEAP3
gene id: 9796:STEAP3
uniprot id: A0A3Q2I0Q6
uniprot id: F7ACD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9796:SDC4
gene id: 9796:SDC4
uniprot id: A0A3Q2GX12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9796:LOC100073265
gene id: 9796:LOC100073265
uniprot id: F6VYL8
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9796:LOC100062850
gene id: 9796:LOC100062850
uniprot id: F7DJ08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PPIL4
gene id: 9796:PPIL4
uniprot id: F6YB81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9796:LOC100053249
gene id: 9796:LOC100053249
uniprot id: F6VSN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

9796:MRPL2
gene id: 9796:MRPL2
uniprot id: F7CEU2
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9796:ATP6V1G2
gene id: 9796:ATP6V1G2
uniprot id: A0A3Q2I006
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9796:KCNT2
gene id: 9796:KCNT2
uniprot id: A0A5F5Q0L9
uniprot id: A0A5F5Q273
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:BARHL2
gene id: 9796:BARHL2
uniprot id: F6RUK8
names: Subcellular Location Annotation
messages: Nucleus

9796:MPEG1
gene id: 9796:MPEG1
uniprot id: F7D1B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9796:NDUFA3
gene id: 9796:NDUFA3
uniprot id: A0A5F5PFK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9796:DIS3
gene id: 9796:DIS3
uniprot id: F6Y5X4
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9796:SF3A3
gene id: 9796:SF3A3
uniprot id: F6SQ60
names: Similarity
messages: Belongs to the SF3A3 family.

9796:RPL5
gene id: 9796:RPL5
uniprot id: A0A5K1VP18
uniprot id: Q8MIN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9796:CLDN4
gene id: 9796:CLDN4
uniprot id: F6Z8Q3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:CHDH
gene id: 9796:CHDH
uniprot id: F6PXM9
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

9796:ECHDC1
gene id: 9796:ECHDC1
uniprot id: K9K4E3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9796:PDE6G
gene id: 9796:PDE6G
uniprot id: F7BEA5
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9796:ZFHX2
gene id: 9796:ZFHX2
uniprot id: F6ZYQ6
names: Subcellular Location Annotation
messages: Nucleus

9796:CCDC124
gene id: 9796:CCDC124
uniprot id: F7DKX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

9796:DSCC1
gene id: 9796:DSCC1
uniprot id: F6TSE2
names: Similarity
messages: Belongs to the DCC1 family.

9796:GRHL3
gene id: 9796:GRHL3
uniprot id: F6RV42
names: Subcellular Location Annotation
messages: Nucleus

9796:NEUROD1
gene id: 9796:NEUROD1
uniprot id: A0A3Q2LT89
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9796:LOC100066499
gene id: 9796:LOC100066499
uniprot id: F7BYN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SPARC
gene id: 9796:SPARC
uniprot id: B8K2M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

9796:LOC100072092
gene id: 9796:LOC100072092
uniprot id: F7B072
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MVK
gene id: 9796:MVK
uniprot id: A0A5F5PNU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm

9796:PRDX6
gene id: 9796:PRDX6
uniprot id: F7AXI9
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9796:LOC100052505
gene id: 9796:LOC100052505
uniprot id: F7AUH2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:LOC100069529
gene id: 9796:LOC100069529
uniprot id: F6Z3S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TMED7
gene id: 9796:TMED7
uniprot id: A0A3Q2IJW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9796:IL5
gene id: 9796:IL5
uniprot id: O02699
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).
messages: Secreted

9796:SEC16A
gene id: 9796:SEC16A
uniprot id: A0A3Q2HY91
uniprot id: F7E1L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

9796:ERO1B
gene id: 9796:ERO1B
uniprot id: A0A3Q2L3N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9796:CASP3
gene id: 9796:CASP3
uniprot id: F7A730
names: Similarity
messages: Belongs to the peptidase C14A family.

9796:C10H19orf54
gene id: 9796:C10H19orf54
uniprot id: F7BEW5
names: Similarity
messages: Belongs to the UPF0692 family.

9796:LOC102150902
gene id: 9796:LOC102150902
uniprot id: F7A4V1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:CLIC1
gene id: 9796:CLIC1
uniprot id: F6ZHQ5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9796:SSTR5
gene id: 9796:SSTR5
uniprot id: F6RAW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:LOC100065777
gene id: 9796:LOC100065777
uniprot id: A0A3Q2HBX0
names: Subcellular Location Annotation
messages: Membrane

9796:NLGN4X
gene id: 9796:NLGN4X
uniprot id: F7CXJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9796:LOC100057768
gene id: 9796:LOC100057768
uniprot id: F7D9Y6
names: Similarity
messages: Belongs to the threonine aldolase family.

9796:RAPGEF2
gene id: 9796:RAPGEF2
uniprot id: A0A3Q2GWL4
uniprot id: A0A3Q2L7N5
uniprot id: A0A3Q2LRM0
uniprot id: A0A3Q2LT30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAPGEF2 family.
messages: Cell junction
messages: Endosome
messages: Late endosome
messages: perinuclear region

9796:TJAP1
gene id: 9796:TJAP1
uniprot id: F6Q2V5
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100056543
gene id: 9796:LOC100056543
uniprot id: F6T7M3
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9796:GYS1
gene id: 9796:GYS1
uniprot id: B2L109
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9796:EIF2B2
gene id: 9796:EIF2B2
uniprot id: F7C702
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9796:MTCH2
gene id: 9796:MTCH2
uniprot id: F7C2H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:SCGN
gene id: 9796:SCGN
uniprot id: F6VXU6
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9796:PSMA2
gene id: 9796:PSMA2
uniprot id: F6TCI4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9796:CTSK
gene id: 9796:CTSK
uniprot id: F7A8R5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Cell membrane
messages: Lysosome
messages: Secreted

9796:HMGN4
gene id: 9796:HMGN4
uniprot id: F7C3E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9796:DCT
gene id: 9796:DCT
uniprot id: F7CBS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9796:LOC100062893
gene id: 9796:LOC100062893
uniprot id: F6UP52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9796:CAPNS1
gene id: 9796:CAPNS1
uniprot id: F6RLT8
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates.
messages: Membrane

9796:B3GAT3
gene id: 9796:B3GAT3
uniprot id: F7AG73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:KRTAP27-1
gene id: 9796:KRTAP27-1
uniprot id: F6QIG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9796:NR5A1
gene id: 9796:NR5A1
uniprot id: Q9GKL2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation stimulates the transcriptional activity.
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with NR0B2. Interacts with DGKQ and CDK7. Binds to and activated by HIPK3 (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity).
messages: Sumoylation reduces CDK7-mediated phosphorylation on Ser-203.
messages: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity).

9796:GRIA1
gene id: 9796:GRIA1
uniprot id: A0A3Q2GSS3
uniprot id: A0A3Q2KMP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9796:ODF1
gene id: 9796:ODF1
uniprot id: A0A3Q2L7U0
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9796:NDUFA10
gene id: 9796:NDUFA10
uniprot id: F6Q938
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

9796:THY1
gene id: 9796:THY1
uniprot id: F6ZC75
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
messages: Membrane

9796:CAP1
gene id: 9796:CAP1
uniprot id: F6SRP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers.
messages: Membrane

9796:LOC100054696
gene id: 9796:LOC100054696
uniprot id: F6QSF7
names: Subcellular Location Annotation
messages: Membrane

9796:SAP130
gene id: 9796:SAP130
uniprot id: A0A5F5PFQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9796:MMP20
gene id: 9796:MMP20
uniprot id: F7BFH0
names: Similarity
messages: Belongs to the peptidase M10A family.

9796:TIMM8B
gene id: 9796:TIMM8B
uniprot id: F7C619
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9796:LOC100064612
gene id: 9796:LOC100064612
uniprot id: A0A7R8C3G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:SPTY2D1
gene id: 9796:SPTY2D1
uniprot id: F7BWP5
names: Similarity
messages: Belongs to the SPT2 family.

9796:ACSF3
gene id: 9796:ACSF3
uniprot id: F7DM96
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9796:RRP7A
gene id: 9796:RRP7A
uniprot id: F7DM75
names: Similarity
messages: Belongs to the RRP7 family.

9796:CAPZB
gene id: 9796:CAPZB
uniprot id: F6Y014
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

9796:ZCCHC17
gene id: 9796:ZCCHC17
uniprot id: A0A3Q2I1Q5
names: Subcellular Location Annotation
messages: nucleolus

9796:SLC17A4
gene id: 9796:SLC17A4
uniprot id: F7C271
names: Subcellular Location Annotation
messages: Membrane

9796:RRM1
gene id: 9796:RRM1
uniprot id: F6YYG9
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9796:STX5
gene id: 9796:STX5
uniprot id: F6QZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9796:LOC100065223
gene id: 9796:LOC100065223
uniprot id: A0A3Q2HJP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9796:LOC100064003
gene id: 9796:LOC100064003
uniprot id: A0A3Q2LB02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MAP2K6
gene id: 9796:MAP2K6
uniprot id: F6QDN0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:PSMF1
gene id: 9796:PSMF1
uniprot id: F6YY33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9796:LOC100067437
gene id: 9796:LOC100067437
uniprot id: F6TZW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CEP162
gene id: 9796:CEP162
uniprot id: A0A3Q2HB19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

9796:PIH1D1
gene id: 9796:PIH1D1
uniprot id: A0A3Q2HR08
names: Similarity
messages: Belongs to the PIH1 family.

9796:GRK1
gene id: 9796:GRK1
uniprot id: F6TZY4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9796:SSTR2
gene id: 9796:SSTR2
uniprot id: F6RFN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9796:MMS22L
gene id: 9796:MMS22L
uniprot id: A0A3Q2HWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Nucleus

9796:DARS2
gene id: 9796:DARS2
uniprot id: A0A3Q2HM61
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9796:AGPAT3
gene id: 9796:AGPAT3
uniprot id: F6UFK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9796:VIPR1
gene id: 9796:VIPR1
uniprot id: A0A3Q2LAF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9796:S1PR1
gene id: 9796:S1PR1
uniprot id: F7BGR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:RTN4
gene id: 9796:RTN4
uniprot id: A0A5F5PUN9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:IST1
gene id: 9796:IST1
uniprot id: A0A3Q2LC76
uniprot id: F6V407
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9796:MAB21L2
gene id: 9796:MAB21L2
uniprot id: F6RJ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

9796:DDX4
gene id: 9796:DDX4
uniprot id: A0A3Q2HK23
uniprot id: A0A3Q2KY57
names: Similarity
messages: Belongs to the DEAD box helicase family.

9796:LOC100058118
gene id: 9796:LOC100058118
uniprot id: A0A3Q2I5E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ANKRD34C
gene id: 9796:ANKRD34C
uniprot id: F6R3L8
names: Similarity
messages: Belongs to the ANKRD34 family.

9796:FAM241B
gene id: 9796:FAM241B
uniprot id: F6RZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9796:SERINC1
gene id: 9796:SERINC1
uniprot id: A0A3Q2HJC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9796:CYP19A1
gene id: 9796:CYP19A1
uniprot id: O46512
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Clone A1 form may be a splice variant or an artifact.
messages: Contains a I helix thought to serve as the substrate-binding pocket.
messages: Endoplasmic reticulum membrane
messages: Expressed in placenta. Highly expressed in follicles (0 hour:hCG), followed by a drop (12-24 hour:hCG) and by an increase (30-39 hour:hCG). Highly expressed in corpora lutea. Also expressed in granulosa cell layer. Not expressed in theca interna.
messages: Microsome membrane

9796:PSMB6
gene id: 9796:PSMB6
uniprot id: F6W2I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9796:EFNB3
gene id: 9796:EFNB3
uniprot id: B0LDT3
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:MASTL
gene id: 9796:MASTL
uniprot id: F6SH20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Nucleus
messages: centrosome

9796:ERAL1
gene id: 9796:ERAL1
uniprot id: F7AFC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

9796:TSPYL5
gene id: 9796:TSPYL5
uniprot id: F6YC53
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9796:TMEM198
gene id: 9796:TMEM198
uniprot id: F6U6R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9796:SMIM12
gene id: 9796:SMIM12
uniprot id: A0A452GES5
uniprot id: F6USH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM12 family.
messages: Membrane

9796:LEO1
gene id: 9796:LEO1
uniprot id: F7CAA5
names: Similarity
messages: Belongs to the LEO1 family.

9796:TRAM1
gene id: 9796:TRAM1
uniprot id: F7AV40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9796:ITGB8
gene id: 9796:ITGB8
uniprot id: F7BLS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9796:OS9
gene id: 9796:OS9
uniprot id: D0V860
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9796:TMCO1
gene id: 9796:TMCO1
uniprot id: A0A5F5PR90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.
messages: Membrane

9796:MRPL17
gene id: 9796:MRPL17
uniprot id: F6R4H9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9796:ARNTL
gene id: 9796:ARNTL
uniprot id: A0MLS5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-538 by CLOCK during the repression phase of the circadian cycle. Acetylation facilitates recruitment of CRY1 protein and initiates the repression phase of the circadian cycle. Acetylated at Lys-538 by KAT5 during the activation phase of the cycle, leading to recruitment of the positive transcription elongation factor b (P-TEFb) and BRD4, followed by productive elongation of circadian transcripts. Deacetylated by SIRT1, which may result in decreased protein stability.
messages: Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins (By similarity). Forms a heterodimer with CLOCK (By similarity). The CLOCK-BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1 (By similarity). Part of a nuclear complex which also includes RACK1 and PRKCA; RACK1 and PRKCA are recruited to the complex in a circadian manner (By similarity). Interacts with NPAS2 (By similarity). Interacts with EZH2 (By similarity). Interacts with SUMO3 (By similarity). Interacts with SIRT1 (By similarity). Interacts with AHR (By similarity). Interacts with ID1, ID2 and ID3 (By similarity). Interacts with DDX4 (By similarity). Interacts with OGT (By similarity). Interacts with EED and SUZ12 (By similarity). Interacts with MTA1 (By similarity). Interacts with CIART (By similarity). Interacts with HSP90 (By similarity). Interacts with KAT2B and EP300 (By similarity). Interacts with BHLHE40/DEC1 and BHLHE41/DEC2 (By similarity). Interacts with RELB and the interaction is enhanced in the presence of CLOCK (By similarity). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (By similarity). Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation (By similarity). Interaction of the CLOCK-BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (By similarity). The CLOCK-BMAL1 heterodimer interacts with GSK3B (By similarity). Interacts with KDM5A (By similarity). Interacts with KMT2A; in a circadian manner (By similarity). Interacts with UBE3A (By similarity). Interacts with PRKCG (By similarity). Interacts with MAGEL2 (By similarity). Interacts with NCOA2 (By similarity). Interacts with THRAP3 (By similarity). The CLOCK-BMAL1 heterodimer interacts with PASD1 (By similarity)…
messages: Cytoplasm
messages: Nucleus
messages: O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-BMAL1 heterodimer thereby increasing CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2/3 and CRY1/2 (By similarity).
messages: PML body
messages: Phosphorylated upon dimerization with CLOCK. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the CLOCK-BMAL1 heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver with a peak between CT10 to CT14. Phosphorylation at Ser-90 by CK2 is essential for its nuclear localization, its interaction with CLOCK and controls CLOCK nuclear entry. Dephosphorylation at Ser-78 is important for dimerization with CLOCK and transcriptional activity.
messages: Sumoylated on Lys-259 upon dimerization with CLOCK. Predominantly conjugated to poly-SUMO2/3 rather than SUMO1 and the level of these conjugates undergo rhythmic variation, peaking at CT9-CT12. Sumoylation localizes it exclusively to the PML body and promotes its ubiquitination in the PML body, ubiquitin-dependent proteasomal degradation and the transcriptional activity of the CLOCK-BMAL1 heterodimer (By similarity).
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …
messages: Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP9X.
messages: Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.

9796:SENP1
gene id: 9796:SENP1
uniprot id: A0A3Q2I6M0
names: Similarity
messages: Belongs to the peptidase C48 family.

9796:TVP23A
gene id: 9796:TVP23A
uniprot id: F7APC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9796:KIAA1024L
gene id: 9796:KIAA1024L
uniprot id: F7CEH4
names: Similarity
messages: Belongs to the MINAR family.

9796:GFRA2
gene id: 9796:GFRA2
uniprot id: A0A3Q2I6F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

9796:TUSC5
gene id: 9796:TUSC5
uniprot id: A0A3Q2GUS7
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9796:LOC100068578
gene id: 9796:LOC100068578
uniprot id: F6W7A4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HAUS3
gene id: 9796:HAUS3
uniprot id: F6SY08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9796:ALG8
gene id: 9796:ALG8
uniprot id: K9KBB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:CLDN1
gene id: 9796:CLDN1
uniprot id: F6TI11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:RAB18
gene id: 9796:RAB18
uniprot id: K9K3M3
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9796:PPIB
gene id: 9796:PPIB
uniprot id: A5YBL8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9796:LOC100062882
gene id: 9796:LOC100062882
uniprot id: F6WW64
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DKC1
gene id: 9796:DKC1
uniprot id: F7C3C0
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9796:RHBG
gene id: 9796:RHBG
uniprot id: F6ZZ85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9796:MRPS21
gene id: 9796:MRPS21
uniprot id: F6YZN2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9796:HPGD
gene id: 9796:HPGD
uniprot id: A2T0Y1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:ECH1
gene id: 9796:ECH1
uniprot id: F6S8M6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9796:METTL14
gene id: 9796:METTL14
uniprot id: F6XVY2
names: Similarity
messages: Belongs to the MT-A70-like family.

9796:PTGS2
gene id: 9796:PTGS2
uniprot id: O19183
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
messages: Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further …
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Microsome membrane
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
messages: S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.
messages: The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.

9796:RPL7L1
gene id: 9796:RPL7L1
uniprot id: F6Y593
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9796:LOC100060476
gene id: 9796:LOC100060476
uniprot id: F7D0M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CACUL1
gene id: 9796:CACUL1
uniprot id: F6PMA7
names: Similarity
messages: Belongs to the cullin family.

9796:PDE7B
gene id: 9796:PDE7B
uniprot id: A0A3Q2I8T7
uniprot id: F6VVL8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9796:UTP3
gene id: 9796:UTP3
uniprot id: F6QJZ7
names: Similarity
messages: Belongs to the SAS10 family.

9796:SUPT16H
gene id: 9796:SUPT16H
uniprot id: F6WKK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9796:PKM
gene id: 9796:PKM
uniprot id: B3IVM0
uniprot id: B3IVM1
names: Similarity
messages: Belongs to the pyruvate kinase family.

9796:DYNLRB1
gene id: 9796:DYNLRB1
uniprot id: F6U5P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9796:MYOZ2
gene id: 9796:MYOZ2
uniprot id: F6SZT9
names: Similarity
messages: Belongs to the myozenin family.

9796:FRG1
gene id: 9796:FRG1
uniprot id: F6WW10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9796:LOC100050544
gene id: 9796:LOC100050544
uniprot id: A0A5F5PZE8
names: Subcellular Location Annotation
messages: Membrane

9796:TPD52L2
gene id: 9796:TPD52L2
uniprot id: A0A3Q2GST2
uniprot id: A0A3Q2I380
uniprot id: F6WKA8
uniprot id: F6YQS5
names: Similarity
messages: Belongs to the TPD52 family.

9796:POLR2C
gene id: 9796:POLR2C
uniprot id: F6W4V5
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9796:IP6K2
gene id: 9796:IP6K2
uniprot id: A0A3Q2H3P5
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9796:DPEP1
gene id: 9796:DPEP1
uniprot id: F6TJM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
messages: Membrane

9796:LOC100060509
gene id: 9796:LOC100060509
uniprot id: A0A3Q2L8S3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TFF2
gene id: 9796:TFF2
uniprot id: F6QHI0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:PDCD10
gene id: 9796:PDCD10
uniprot id: F6S0Q4
uniprot id: L7MRY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9796:DUS4L
gene id: 9796:DUS4L
uniprot id: F7D7E2
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9796:SMG8
gene id: 9796:SMG8
uniprot id: F7DR34
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

9796:LOC100060524
gene id: 9796:LOC100060524
uniprot id: A0A3Q2I6K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CHMP4C
gene id: 9796:CHMP4C
uniprot id: F6U218
names: Similarity
messages: Belongs to the SNF7 family.

9796:ATP6V1E2
gene id: 9796:ATP6V1E2
uniprot id: F6ZMJ5
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9796:METTL6
gene id: 9796:METTL6
uniprot id: F6QR92
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9796:FAM46C
gene id: 9796:FAM46C
uniprot id: F7DFD9
names: Similarity
messages: Belongs to the TENT family.

9796:ORC4
gene id: 9796:ORC4
uniprot id: A0A3Q2GYH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9796:FGF2
gene id: 9796:FGF2
uniprot id: E0AEV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Nucleus
messages: Secreted

9796:BYSL
gene id: 9796:BYSL
uniprot id: F6RNL5
names: Similarity
messages: Belongs to the bystin family.

9796:SLC26A3
gene id: 9796:SLC26A3
uniprot id: F6XD85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Chloride/bicarbonate exchanger.
messages: Membrane

9796:MRPL33
gene id: 9796:MRPL33
uniprot id: A0A3Q2H5S7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9796:INTS7
gene id: 9796:INTS7
uniprot id: F7AUP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9796:MCIDAS
gene id: 9796:MCIDAS
uniprot id: F6Y7R8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the geminin family.
messages: Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.
messages: Nucleus

9796:TIPRL
gene id: 9796:TIPRL
uniprot id: F6YE97
names: Similarity
messages: Belongs to the TIP41 family.

9796:TPMT
gene id: 9796:TPMT
uniprot id: Q3BCR6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9796:VPS37A
gene id: 9796:VPS37A
uniprot id: F7BV47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9796:KDM4A
gene id: 9796:KDM4A
uniprot id: F7A0K8
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9796:KCNJ2
gene id: 9796:KCNJ2
uniprot id: F7C3Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

9796:FABP6
gene id: 9796:FABP6
uniprot id: F6YZS2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9796:PLPBP
gene id: 9796:PLPBP
uniprot id: A0A3Q2H1A2
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9796:PCMT1
gene id: 9796:PCMT1
uniprot id: F7A5R3
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9796:LOC100071946
gene id: 9796:LOC100071946
uniprot id: F6U6Y2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:RPSA
gene id: 9796:RPSA
uniprot id: B8K1X7
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9796:CCT8
gene id: 9796:CCT8
uniprot id: F6ZQE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

9796:CLUAP1
gene id: 9796:CLUAP1
uniprot id: A0A3Q2GYZ8
uniprot id: F6WNW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9796:FOXC2
gene id: 9796:FOXC2
uniprot id: A2SZB8
names: Subcellular Location Annotation
messages: Nucleus

9796:S1PR2
gene id: 9796:S1PR2
uniprot id: F6S391
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9796:GRB2
gene id: 9796:GRB2
uniprot id: F7BQS3
uniprot id: L7MSX1
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9796:BCL2
gene id: 9796:BCL2
uniprot id: F7CDX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

9796:CENPX
gene id: 9796:CENPX
uniprot id: A0A5F5PNT6
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

9796:THOC5
gene id: 9796:THOC5
uniprot id: A0A3Q2HXL2
uniprot id: A0A3Q2IAG7
uniprot id: A0A3Q2KXM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9796:MAP3K8
gene id: 9796:MAP3K8
uniprot id: F7CNR6
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9796:WLS
gene id: 9796:WLS
uniprot id: A0A3Q2HI43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9796:GPR87
gene id: 9796:GPR87
uniprot id: F7BQM6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:LOC111767417
gene id: 9796:LOC111767417
uniprot id: A0A5F5Q3B6
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

9796:MRPL11
gene id: 9796:MRPL11
uniprot id: F7AQF6
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9796:TMEM182
gene id: 9796:TMEM182
uniprot id: A0A3Q2KSH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9796:KRT82
gene id: 9796:KRT82
uniprot id: F7CJ64
names: Similarity
messages: Belongs to the intermediate filament family.

9796:SENP8
gene id: 9796:SENP8
uniprot id: F6YXM4
names: Similarity
messages: Belongs to the peptidase C48 family.

9796:TRNAU1AP
gene id: 9796:TRNAU1AP
uniprot id: F6R176
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9796:LOC100050867
gene id: 9796:LOC100050867
uniprot id: F6RCI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NDUFA1
gene id: 9796:NDUFA1
uniprot id: F6VHR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9796:RAG1
gene id: 9796:RAG1
uniprot id: F6WSB4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.
messages: Homodimer.
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.

9796:PSMB3
gene id: 9796:PSMB3
uniprot id: F6TV65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9796:TEKT1
gene id: 9796:TEKT1
uniprot id: F6S9H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9796:SLC10A2
gene id: 9796:SLC10A2
uniprot id: F7A9H8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

9796:PALMD
gene id: 9796:PALMD
uniprot id: F6TV06
names: Similarity
messages: Belongs to the paralemmin family.

9796:LOC100068374
gene id: 9796:LOC100068374
uniprot id: F6ZJH1
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9796:TAAR5
gene id: 9796:TAAR5
uniprot id: F6Z9Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9796:C12H11orf49
gene id: 9796:C12H11orf49
uniprot id: A0A3Q2HTF2
uniprot id: F6SJ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: centriolar satellite

9796:LOC100069365
gene id: 9796:LOC100069365
uniprot id: F6YSH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CYP3A96
gene id: 9796:CYP3A96
uniprot id: C9WMG3
uniprot id: D7GB59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:G6PC2
gene id: 9796:G6PC2
uniprot id: A0A3Q2H3S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9796:TXLNA
gene id: 9796:TXLNA
uniprot id: F6VUK6
names: Similarity
messages: Belongs to the taxilin family.

9796:PDGFRA
gene id: 9796:PDGFRA
uniprot id: F7A2X2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9796:LOC100053994
gene id: 9796:LOC100053994
uniprot id: A0A3Q2LL46
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:PRMT7
gene id: 9796:PRMT7
uniprot id: F6ZH13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

9796:LOC100073110
gene id: 9796:LOC100073110
uniprot id: F7AN39
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:GCNT7
gene id: 9796:GCNT7
uniprot id: F7DVB7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9796:LOC100054193
gene id: 9796:LOC100054193
uniprot id: F7DIN7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:PRPH2
gene id: 9796:PRPH2
uniprot id: F6WQU8
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9796:LOC100057267
gene id: 9796:LOC100057267
uniprot id: A0A3Q2HJD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SLC29A1
gene id: 9796:SLC29A1
uniprot id: A0A3Q2HRQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9796:ADCY4
gene id: 9796:ADCY4
uniprot id: F6ZH58
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9796:TAS2R7
gene id: 9796:TAS2R7
uniprot id: F6YL32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Membrane

9796:SNAP23
gene id: 9796:SNAP23
uniprot id: F6XAB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9796:LOC100062409
gene id: 9796:LOC100062409
uniprot id: F6U178
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CMC1
gene id: 9796:CMC1
uniprot id: F6V1Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9796:ELOC
gene id: 9796:ELOC
uniprot id: F7D5C0
names: Similarity
messages: Belongs to the SKP1 family.

9796:TMEM39A
gene id: 9796:TMEM39A
uniprot id: F6T4N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9796:RAB39A
gene id: 9796:RAB39A
uniprot id: F6XUT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9796:NRN1
gene id: 9796:NRN1
uniprot id: F7DF40
names: Similarity
messages: Belongs to the neuritin family.

9796:RPS26
gene id: 9796:RPS26
uniprot id: F6YKH4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9796:TUBA8
gene id: 9796:TUBA8
uniprot id: F6ZRY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9796:LOC100059132
gene id: 9796:LOC100059132
uniprot id: F6RK09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100054849
gene id: 9796:LOC100054849
uniprot id: F6QCG3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:QARS
gene id: 9796:QARS
uniprot id: F6WN90
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9796:BCL2L14
gene id: 9796:BCL2L14
uniprot id: F6PXU1
names: Similarity
messages: Belongs to the Bcl-2 family.

9796:ACSL5
gene id: 9796:ACSL5
uniprot id: A0A3Q2HSE7
uniprot id: A0A3Q2KPY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9796:GSTA1
gene id: 9796:GSTA1
uniprot id: M9ZUR8
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9796:PSMB2
gene id: 9796:PSMB2
uniprot id: F6WL01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9796:STX16
gene id: 9796:STX16
uniprot id: A0A3Q2HVW1
uniprot id: F7AW52
names: Similarity
messages: Belongs to the syntaxin family.

9796:HAX1
gene id: 9796:HAX1
uniprot id: K9K3F5
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

9796:CD3D
gene id: 9796:CD3D
uniprot id: F7CIT2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:RHCG
gene id: 9796:RHCG
uniprot id: F6Q0U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9796:LOC100067483
gene id: 9796:LOC100067483
uniprot id: A0A3Q2KL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9796:THTPA
gene id: 9796:THTPA
uniprot id: A0A3Q2HAN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9796:LOC100071297
gene id: 9796:LOC100071297
uniprot id: F7CI87
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SLC9A5
gene id: 9796:SLC9A5
uniprot id: F6VLD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9796:NEK6
gene id: 9796:NEK6
uniprot id: F6PJ99
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:DHRS11
gene id: 9796:DHRS11
uniprot id: F6Q645
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:MYF6
gene id: 9796:MYF6
uniprot id: F6ZFC9
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100056816
gene id: 9796:LOC100056816
uniprot id: A0A3Q2I9F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CAVIN4
gene id: 9796:CAVIN4
uniprot id: F7A8K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

9796:LOC100072120
gene id: 9796:LOC100072120
uniprot id: A0A3Q2I5Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TFEC
gene id: 9796:TFEC
uniprot id: A0A3Q2GUC0
uniprot id: A0A3Q2HDJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9796:LTN1
gene id: 9796:LTN1
uniprot id: F6ZU08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

9796:TMIGD3
gene id: 9796:TMIGD3
uniprot id: A0A3Q2HI03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9796:GSTO2
gene id: 9796:GSTO2
uniprot id: F6RLD7
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9796:ARF3
gene id: 9796:ARF3
uniprot id: F6TD06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9796:EDC4
gene id: 9796:EDC4
uniprot id: F7BBD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9796:PLSCR5
gene id: 9796:PLSCR5
uniprot id: A0A3Q2HMS4
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9796:VAMP5
gene id: 9796:VAMP5
uniprot id: F7DCD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9796:LOC100072089
gene id: 9796:LOC100072089
uniprot id: F7B4J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RRP15
gene id: 9796:RRP15
uniprot id: F6SAF6
names: Similarity
messages: Belongs to the RRP15 family.

9796:GTPBP8
gene id: 9796:GTPBP8
uniprot id: A0A3Q2H1Q0
uniprot id: A0A3Q2IAW8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9796:ACSL1
gene id: 9796:ACSL1
uniprot id: F6SAH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9796:SPAG7
gene id: 9796:SPAG7
uniprot id: F7DXC6
names: Subcellular Location Annotation
messages: Nucleus

9796:CENPT
gene id: 9796:CENPT
uniprot id: F6PKQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

9796:CCT7
gene id: 9796:CCT7
uniprot id: F6XSN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9796:TMEM176A
gene id: 9796:TMEM176A
uniprot id: A0A3Q2HSZ0
names: Similarity
messages: Belongs to the TMEM176 family.

9796:SMC3
gene id: 9796:SMC3
uniprot id: A0A3Q2HBC4
uniprot id: K9KCG5
uniprot id: L7MRK9
uniprot id: L7MS50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Chromosome
messages: Nucleus
messages: centromere

9796:HTRA2
gene id: 9796:HTRA2
uniprot id: F7DWY7
names: Similarity
messages: Belongs to the peptidase S1C family.

9796:PANX3
gene id: 9796:PANX3
uniprot id: F6TM26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9796:COPS9
gene id: 9796:COPS9
uniprot id: A0A5F5PUK2
names: Similarity
messages: Belongs to the CSN9 family.

9796:CLSTN3
gene id: 9796:CLSTN3
uniprot id: F6VJD0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9796:FNIP2
gene id: 9796:FNIP2
uniprot id: A0A3Q2L9K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9796:POLH
gene id: 9796:POLH
uniprot id: F6SCT4
names: Subcellular Location Annotation
messages: Nucleus

9796:GNPDA1
gene id: 9796:GNPDA1
uniprot id: F6T471
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9796:SESN1
gene id: 9796:SESN1
uniprot id: A0A5F5PFW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9796:CACNG3
gene id: 9796:CACNG3
uniprot id: F6V9P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9796:PSD3
gene id: 9796:PSD3
uniprot id: A0A3Q2H4F2
names: Subcellular Location Annotation
messages: ruffle membrane

9796:LOC100072179
gene id: 9796:LOC100072179
uniprot id: F6UGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TMEM50B
gene id: 9796:TMEM50B
uniprot id: F6VXN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9796:LAMB2
gene id: 9796:LAMB2
uniprot id: F7BK38
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9796:PAICS
gene id: 9796:PAICS
uniprot id: F7D7Z9
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9796:LOC100049851
gene id: 9796:LOC100049851
uniprot id: F6QDH8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9796:LOC100063059
gene id: 9796:LOC100063059
uniprot id: F7A287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9796:LAPTM4A
gene id: 9796:LAPTM4A
uniprot id: F6X1D5
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9796:LOC100056985
gene id: 9796:LOC100056985
uniprot id: F7E310
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MLN
gene id: 9796:MLN
uniprot id: F7BG48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

9796:B3GALNT2
gene id: 9796:B3GALNT2
uniprot id: A0A5F5PGY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:TIMP3
gene id: 9796:TIMP3
uniprot id: Q9TUL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.
messages: Interacts with EFEMP1.
messages: extracellular matrix

9796:RXFP2
gene id: 9796:RXFP2
uniprot id: F7DJQ1
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:HK2
gene id: 9796:HK2
uniprot id: A2PYL6
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hexokinase family.
messages: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
messages: Hexokinase activity is specifically inhibited by 2,6-disubstituted glucosamines.
messages: Mitochondrion outer membrane
messages: Monomer (By similarity). Interacts with TIGAR; the interaction increases hexokinase activity in a hypoxia- and HIF1A-dependent manner (By similarity).
messages: The N- and C-terminal halves of the protein contain a hexokinase domain. In contrast to hexokinase-1 and -3 (HK1 and HK3, respectively), both hexokinase domains display catalytic activity. The region connecting the two hexokinase domains is required for the catalytic activity of the N-terminal hexokinase domain. The N-terminal half regulates stability of the whole enzyme.
messages: cytosol

9796:UCN3
gene id: 9796:UCN3
uniprot id: F6VA03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9796:FAM96B
gene id: 9796:FAM96B
uniprot id: F7DB83
names: Similarity
messages: Belongs to the MIP18 family.

9796:PCYT1B
gene id: 9796:PCYT1B
uniprot id: A0A3Q2HF87
uniprot id: A0A3Q2HJI2
uniprot id: F6YJJ8
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9796:AASDHPPT
gene id: 9796:AASDHPPT
uniprot id: A0A5F5PTV0
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

9796:LOC100067368
gene id: 9796:LOC100067368
uniprot id: F6VQ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9796:LOC100055538
gene id: 9796:LOC100055538
uniprot id: F6WQZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FAM126A
gene id: 9796:FAM126A
uniprot id: A0A3Q2L0S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9796:APP
gene id: 9796:APP
uniprot id: A0A5F5PLP1
uniprot id: A0A5F5PX07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Secreted
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9796:SNCG
gene id: 9796:SNCG
uniprot id: F6ZPR2
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

9796:MLEC
gene id: 9796:MLEC
uniprot id: F6Z049
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:IFI27
gene id: 9796:IFI27
uniprot id: F6WPD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9796:STAMBPL1
gene id: 9796:STAMBPL1
uniprot id: F6VUG1
names: Similarity
messages: Belongs to the peptidase M67C family.

9796:LOC100057625
gene id: 9796:LOC100057625
uniprot id: A0A3Q2GSB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ABI1
gene id: 9796:ABI1
uniprot id: A0A3Q2HIC5
uniprot id: A0A5F5PH88
uniprot id: A0A5F5PHV0
uniprot id: F6VYM9
uniprot id: F6VYP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9796:TTC26
gene id: 9796:TTC26
uniprot id: F7CHH6
names: Similarity
messages: Belongs to the IFT56 family.

9796:LOC100147364
gene id: 9796:LOC100147364
uniprot id: F7A6J6
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

9796:KLHL3
gene id: 9796:KLHL3
uniprot id: F6WHB6
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

9796:LOC100055518
gene id: 9796:LOC100055518
uniprot id: A0A3Q2IBH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RPS11
gene id: 9796:RPS11
uniprot id: F7DU34
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9796:VAMP8
gene id: 9796:VAMP8
uniprot id: F6YR57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9796:LOC100057377
gene id: 9796:LOC100057377
uniprot id: F7D9X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ATP2C1
gene id: 9796:ATP2C1
uniprot id: A0A3Q2IA11
uniprot id: A0A5F5PM75
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

9796:CSGALNACT1
gene id: 9796:CSGALNACT1
uniprot id: F6PHP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9796:IREB2
gene id: 9796:IREB2
uniprot id: F6Z746
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

9796:PPP6R3
gene id: 9796:PPP6R3
uniprot id: A9CS55
names: Similarity
messages: Belongs to the SAPS family.

9796:ICOS
gene id: 9796:ICOS
uniprot id: A0A3Q2HRX2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9796:LOC100052091
gene id: 9796:LOC100052091
uniprot id: F7BS18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:C2H1orf174
gene id: 9796:C2H1orf174
uniprot id: F7E475
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9796:SLC25A20
gene id: 9796:SLC25A20
uniprot id: F7DCX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:SLC25A5
gene id: 9796:SLC25A5
uniprot id: K9KEM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9796:LTV1
gene id: 9796:LTV1
uniprot id: F7DC99
names: Similarity
messages: Belongs to the LTV1 family.

9796:ALG11
gene id: 9796:ALG11
uniprot id: F7DAI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9796:PPIA
gene id: 9796:PPIA
uniprot id: F6X6A6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9796:CAVIN1
gene id: 9796:CAVIN1
uniprot id: A0A3Q2GTR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9796:DNAJC16
gene id: 9796:DNAJC16
uniprot id: F6T037
names: Subcellular Location Annotation
messages: Membrane

9796:ZFP69B
gene id: 9796:ZFP69B
uniprot id: F6T5P9
names: Subcellular Location Annotation
messages: Nucleus

9796:ATP5PD
gene id: 9796:ATP5PD
uniprot id: F6YAZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9796:LOC100054771
gene id: 9796:LOC100054771
uniprot id: A0A3Q2I6J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SNRPB
gene id: 9796:SNRPB
uniprot id: F6VEH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9796:LOC100055813
gene id: 9796:LOC100055813
uniprot id: A0A3Q2IB17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9796:NFS1
gene id: 9796:NFS1
uniprot id: F6VUU0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9796:GTPBP4
gene id: 9796:GTPBP4
uniprot id: A0A3Q2HP98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9796:LOC100067059
gene id: 9796:LOC100067059
uniprot id: F7D1L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HRH1
gene id: 9796:HRH1
uniprot id: F6PS14
uniprot id: Q0PW07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:ZBED4
gene id: 9796:ZBED4
uniprot id: F7D635
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100057150
gene id: 9796:LOC100057150
uniprot id: A0A3Q2H8U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PRMT5
gene id: 9796:PRMT5
uniprot id: F7D2I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9796:EQUCABV1R908
gene id: 9796:EQUCABV1R908
uniprot id: F6WJ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:RPL32
gene id: 9796:RPL32
uniprot id: F7BVJ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9796:IL1A
gene id: 9796:IL1A
uniprot id: F7C3T8
uniprot id: Q28385
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated within its nuclear localization sequence, which impacts subcellular localization.
messages: Belongs to the IL-1 family.
messages: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
messages: Cytoplasm
messages: Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.
messages: Nucleus
messages: Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.
messages: Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.
messages: Secreted
messages: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

9796:RAG2
gene id: 9796:RAG2
uniprot id: F6WS62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9796:LOC100072662
gene id: 9796:LOC100072662
uniprot id: F6UGR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MINDY3
gene id: 9796:MINDY3
uniprot id: F7DRK3
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9796:PLOD1
gene id: 9796:PLOD1
uniprot id: F6V2X7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9796:RBP4
gene id: 9796:RBP4
uniprot id: Q28369
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.
messages: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
messages: Secreted

9796:ITGB6
gene id: 9796:ITGB6
uniprot id: A0A3Q2HZL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9796:PFKFB2
gene id: 9796:PFKFB2
uniprot id: A0A3Q2ID42
uniprot id: F6PPT4
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9796:SEC24D
gene id: 9796:SEC24D
uniprot id: F7A9B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9796:KEF40 p05
gene id: 9796:KEF40_p05
uniprot id: P48658
uniprot id: Q6J6W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9796:ACAD11
gene id: 9796:ACAD11
uniprot id: F7DQ12
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9796:LPGAT1
gene id: 9796:LPGAT1
uniprot id: F7BJG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9796:PRAF2
gene id: 9796:PRAF2
uniprot id: F7DXZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9796:LOC100067873
gene id: 9796:LOC100067873
uniprot id: F7BS24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CHST6
gene id: 9796:CHST6
uniprot id: F6VXD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9796:CD70
gene id: 9796:CD70
uniprot id: F6XHL7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9796:ARMC1
gene id: 9796:ARMC1
uniprot id: F6X3R8
uniprot id: L7MS15
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9796:MRPS15
gene id: 9796:MRPS15
uniprot id: F7D6G0
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9796:LOC100058358
gene id: 9796:LOC100058358
uniprot id: F6PH57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9796:GRIA3
gene id: 9796:GRIA3
uniprot id: A0A3Q2H716
uniprot id: F6SWX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9796:AIFM1
gene id: 9796:AIFM1
uniprot id: A0A5F5PMZ3
uniprot id: F6WXF6
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9796:PTGS1
gene id: 9796:PTGS1
uniprot id: F7BQR7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:FAS
gene id: 9796:FAS
uniprot id: F6ZZH9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

9796:LOC100056754
gene id: 9796:LOC100056754
uniprot id: F6SWS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ENTPD6
gene id: 9796:ENTPD6
uniprot id: F6ZHF7
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9796:HTR5A
gene id: 9796:HTR5A
uniprot id: F7A8C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:LOC100062545
gene id: 9796:LOC100062545
uniprot id: F6VCQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NEMP1
gene id: 9796:NEMP1
uniprot id: F6YYB8
uniprot id: K9KAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9796:LOC100067223
gene id: 9796:LOC100067223
uniprot id: A0A3Q2IGQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100053210
gene id: 9796:LOC100053210
uniprot id: F7A317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:FOLR3
gene id: 9796:FOLR3
uniprot id: A0A3Q2H4A7
names: Similarity
messages: Belongs to the folate receptor family.

9796:GRP
gene id: 9796:GRP
uniprot id: F7DYM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.
messages: Secreted
messages: neuron projection
messages: secretory vesicle lumen

9796:DCST2
gene id: 9796:DCST2
uniprot id: F7DZK9
names: Subcellular Location Annotation
messages: Membrane

9796:BLCAP
gene id: 9796:BLCAP
uniprot id: A0A3Q2IDT5
names: Similarity
messages: Belongs to the BLCAP family.

9796:DLD
gene id: 9796:DLD
uniprot id: F6U3F1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9796:TFDP2
gene id: 9796:TFDP2
uniprot id: F6X5K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9796:ATG5
gene id: 9796:ATG5
uniprot id: F6ZLD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9796:LOC100058205
gene id: 9796:LOC100058205
uniprot id: F7B0W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100054881
gene id: 9796:LOC100054881
uniprot id: A0A3Q2H4I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ALLC
gene id: 9796:ALLC
uniprot id: F7AJG7
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9796:PCOLCE
gene id: 9796:PCOLCE
uniprot id: F6WZ69
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:PTK6
gene id: 9796:PTK6
uniprot id: F6ZIG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9796:LRP6
gene id: 9796:LRP6
uniprot id: F7DHA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:DDC
gene id: 9796:DDC
uniprot id: F6ZPG5
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9796:GNG3
gene id: 9796:GNG3
uniprot id: F6T6I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9796:IP6K1
gene id: 9796:IP6K1
uniprot id: F6XC24
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9796:FAM136A
gene id: 9796:FAM136A
uniprot id: A0A3Q2ICC1
names: Similarity
messages: Belongs to the FAM136 family.

9796:NOP10
gene id: 9796:NOP10
uniprot id: F6PRC7
names: Similarity
messages: Belongs to the NOP10 family.

9796:GPM6B
gene id: 9796:GPM6B
uniprot id: A0A3Q2H9M5
uniprot id: A0A5F5PQE4
uniprot id: F7DYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9796:KAT7
gene id: 9796:KAT7
uniprot id: A0A3Q2HQZ7
uniprot id: F6SN79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9796:CDC26
gene id: 9796:CDC26
uniprot id: A0A3Q2HW45
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9796:CD151
gene id: 9796:CD151
uniprot id: F6RLK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9796:FAM49B
gene id: 9796:FAM49B
uniprot id: F7C871
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9796:CPB1
gene id: 9796:CPB1
uniprot id: F6XIJ7
names: Similarity
messages: Belongs to the peptidase M14 family.

9796:KCNK5
gene id: 9796:KCNK5
uniprot id: F6VJB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9796:DQA
gene id: 9796:DQA
uniprot id: A0A3Q2KS93
uniprot id: A0A5F5PVK7
uniprot id: K9MCE6
uniprot id: Q30457
names: Similarity
messages: Belongs to the MHC class II family.

9796:VDAC2
gene id: 9796:VDAC2
uniprot id: F6TLU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Mitochondrion outer membrane

9796:USP7
gene id: 9796:USP7
uniprot id: A0A3Q2GWN6
names: Similarity
messages: Belongs to the peptidase C19 family.

9796:LMNA
gene id: 9796:LMNA
uniprot id: F6ZY40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9796:NRG1
gene id: 9796:NRG1
uniprot id: A0A3Q2GV63
uniprot id: F6RG52
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9796:TPST2
gene id: 9796:TPST2
uniprot id: A0A3Q2HJR3
uniprot id: F6SNC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9796:KIAA0391
gene id: 9796:KIAA0391
uniprot id: A0A3Q2GSH9
uniprot id: K9KBG0
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9796:TMEM2
gene id: 9796:TMEM2
uniprot id: F6Z4U0
names: Similarity
messages: Belongs to the CEMIP family.

9796:LOC100053403
gene id: 9796:LOC100053403
uniprot id: A0A3Q2IAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:MCM4
gene id: 9796:MCM4
uniprot id: F7DJ41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9796:SPATA18
gene id: 9796:SPATA18
uniprot id: A0A5F5PRS9
uniprot id: F6R2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9796:IL37
gene id: 9796:IL37
uniprot id: A0A5F5PKJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9796:SULF1
gene id: 9796:SULF1
uniprot id: F6PP52
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9796:RPLP0
gene id: 9796:RPLP0
uniprot id: F6TTP1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9796:KNG1
gene id: 9796:KNG1
uniprot id: A0A5F5PUE2
uniprot id: F7C0D9
names: Subcellular Location Annotation
messages: extracellular space

9796:TDRD5
gene id: 9796:TDRD5
uniprot id: A0A3Q2H6T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.

9796:BRMS1L
gene id: 9796:BRMS1L
uniprot id: F7AQW8
names: Subcellular Location Annotation
messages: Nucleus

9796:AMIGO3
gene id: 9796:AMIGO3
uniprot id: F6SQI1
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9796:ACTA1
gene id: 9796:ACTA1
uniprot id: F7CZ92
names: Similarity
messages: Belongs to the actin family.

9796:TROVE2
gene id: 9796:TROVE2
uniprot id: F7AA69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9796:CENPI
gene id: 9796:CENPI
uniprot id: F6ZC44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

9796:KEF40 p01
gene id: 9796:KEF40_p01
uniprot id: P48665
uniprot id: Q53YR5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9796:SLC17A9
gene id: 9796:SLC17A9
uniprot id: F6SRV0
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100070356
gene id: 9796:LOC100070356
uniprot id: F6XMI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CFAP97
gene id: 9796:CFAP97
uniprot id: F7CMA4
names: Similarity
messages: Belongs to the CFAP97 family.

9796:BARHL1
gene id: 9796:BARHL1
uniprot id: F6W4G4
names: Subcellular Location Annotation
messages: Nucleus

9796:ARPC5L
gene id: 9796:ARPC5L
uniprot id: F6ZP76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: May be a component of the Arp2/3 complex in which it may replace ARPC5.
messages: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9796:BTF3
gene id: 9796:BTF3
uniprot id: F6YY47
names: Similarity
messages: Belongs to the NAC-beta family.

9796:LOC100057699
gene id: 9796:LOC100057699
uniprot id: A0A3Q2L7P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PNLIP
gene id: 9796:PNLIP
uniprot id: F7BR43
uniprot id: P29183
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Forms a 1:1 stoichiometric complex with (pro)colipase/CLPS.
messages: Inhibited by bile salts, is reactivated by (pro)colipase/CLPS.
messages: Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
messages: Secreted

9796:APOBEC3Z1B
gene id: 9796:APOBEC3Z1B
uniprot id: C7AGG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Nucleus
messages: P-body

9796:MYLK4
gene id: 9796:MYLK4
uniprot id: A0A3Q2IC91
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:LOC100072621
gene id: 9796:LOC100072621
uniprot id: A0A3Q2H0K2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FOXS1
gene id: 9796:FOXS1
uniprot id: F7C4Y0
names: Subcellular Location Annotation
messages: Nucleus

9796:FAM46A
gene id: 9796:FAM46A
uniprot id: F7AJW0
names: Similarity
messages: Belongs to the TENT family.

9796:CLTA
gene id: 9796:CLTA
uniprot id: A0A5F5PEW2
uniprot id: A0A5F5PF40
uniprot id: C0SW05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9796:TRMT13
gene id: 9796:TRMT13
uniprot id: F6U2I9
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9796:SCG5
gene id: 9796:SCG5
uniprot id: F6VTN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9796:SMAD1
gene id: 9796:SMAD1
uniprot id: F6W0G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9796:FAM167A
gene id: 9796:FAM167A
uniprot id: A0A3Q2I2H8
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9796:CA1
gene id: 9796:CA1
uniprot id: F6ZBG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9796:ABHD16A
gene id: 9796:ABHD16A
uniprot id: F7BM46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

9796:RHBDD3
gene id: 9796:RHBDD3
uniprot id: F6UQN5
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100629714
gene id: 9796:LOC100629714
uniprot id: A0A3Q2H0G3
names: Similarity
messages: Belongs to the KRTAP type 3 family.

9796:AGK
gene id: 9796:AGK
uniprot id: F7DU11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9796:BSCL2
gene id: 9796:BSCL2
uniprot id: F7A3C7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:LOC100061296
gene id: 9796:LOC100061296
uniprot id: F6WN36
names: Similarity
messages: Belongs to the MS4A family.

9796:ZIC4
gene id: 9796:ZIC4
uniprot id: F7CLD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9796:GPD2
gene id: 9796:GPD2
uniprot id: A0A3Q2GVG9
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

9796:PYCR2
gene id: 9796:PYCR2
uniprot id: F7C780
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9796:TMEM136
gene id: 9796:TMEM136
uniprot id: F6ZK18
names: Subcellular Location Annotation
messages: Membrane

9796:HSD17B10
gene id: 9796:HSD17B10
uniprot id: F6V5A0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:DNASE2B
gene id: 9796:DNASE2B
uniprot id: F7BX32
names: Similarity
messages: Belongs to the DNase II family.

9796:SNU13
gene id: 9796:SNU13
uniprot id: F7DTJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9796:EBAG9
gene id: 9796:EBAG9
uniprot id: F6WHY8
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9796:CD93
gene id: 9796:CD93
uniprot id: F6TH29
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:CYSLTR1
gene id: 9796:CYSLTR1
uniprot id: F7DF45
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:MED7
gene id: 9796:MED7
uniprot id: K9K3K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9796:NUDT21
gene id: 9796:NUDT21
uniprot id: F6VD51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

9796:MAN2A1
gene id: 9796:MAN2A1
uniprot id: F6VHV0
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9796:TF
gene id: 9796:TF
uniprot id: P27425
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transferrin family.
messages: Expressed by the liver and secreted in plasma.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

9796:RPL22L1
gene id: 9796:RPL22L1
uniprot id: A0A5F5PTZ3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9796:B3GALT2
gene id: 9796:B3GALT2
uniprot id: F7C2T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:SLC9A1
gene id: 9796:SLC9A1
uniprot id: F7BH15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
messages: Membrane

9796:PLAC8L1
gene id: 9796:PLAC8L1
uniprot id: F6Z2J4
names: Similarity
messages: Belongs to the cornifelin family.

9796:PSENEN
gene id: 9796:PSENEN
uniprot id: F7DGZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9796:PPP2R5C
gene id: 9796:PPP2R5C
uniprot id: F7D9E5
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9796:LOC106780858
gene id: 9796:LOC106780858
uniprot id: F7CI93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:INPP4A
gene id: 9796:INPP4A
uniprot id: A0A3Q2HXC9
uniprot id: F7A9E9
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9796:NKX2-6
gene id: 9796:NKX2-6
uniprot id: A0A3Q2L478
names: Subcellular Location Annotation
messages: Nucleus

9796:FRZB
gene id: 9796:FRZB
uniprot id: F6WNV3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9796:ETFDH
gene id: 9796:ETFDH
uniprot id: A0A3Q2HQA1
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9796:SLC52A3
gene id: 9796:SLC52A3
uniprot id: A0A3Q2HDF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9796:RPS8
gene id: 9796:RPS8
uniprot id: F7DW15
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9796:LIX1
gene id: 9796:LIX1
uniprot id: F6WLP6
names: Similarity
messages: Belongs to the LIX1 family.

9796:LOC100630245
gene id: 9796:LOC100630245
uniprot id: F6VKS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RNASE4
gene id: 9796:RNASE4
uniprot id: W0UVF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9796:VAC14
gene id: 9796:VAC14
uniprot id: F6QTT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9796:HSPB8
gene id: 9796:HSPB8
uniprot id: F7A2F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9796:CHRNG
gene id: 9796:CHRNG
uniprot id: F7AHA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:RPL12
gene id: 9796:RPL12
uniprot id: F6T1A4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9796:EQUCABV1R911
gene id: 9796:EQUCABV1R911
uniprot id: A0A3Q2GZR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:LOC100052108
gene id: 9796:LOC100052108
uniprot id: F7AX17
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9796:CRISP2
gene id: 9796:CRISP2
uniprot id: Q8HX97
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:MAPK6
gene id: 9796:MAPK6
uniprot id: A0A3Q2IAL0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9796:AP4B1
gene id: 9796:AP4B1
uniprot id: F6YPY8
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9796:LOC100051657
gene id: 9796:LOC100051657
uniprot id: Q860N7
names: Similarity
messages: Belongs to the MHC class I family.

9796:BSX
gene id: 9796:BSX
uniprot id: A0A3Q2HG05
names: Subcellular Location Annotation
messages: Nucleus

9796:GSTA3
gene id: 9796:GSTA3
uniprot id: M9ZT87
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9796:CD28
gene id: 9796:CD28
uniprot id: A7LBQ6
names: Subcellular Location Annotation
messages: Membrane

9796:LBR
gene id: 9796:LBR
uniprot id: A0A3Q2GWX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9796:PES1
gene id: 9796:PES1
uniprot id: F6RB00
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

9796:RPL37
gene id: 9796:RPL37
uniprot id: A0A5F5PRZ1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9796:ARMC8
gene id: 9796:ARMC8
uniprot id: A0A3Q2I9A6
uniprot id: F7CYC8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9796:HTR2A
gene id: 9796:HTR2A
uniprot id: Q0EAB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

9796:SCRN3
gene id: 9796:SCRN3
uniprot id: A0A5F5Q0L2
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9796:LOC100071911
gene id: 9796:LOC100071911
uniprot id: F7DZZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LSM8
gene id: 9796:LSM8
uniprot id: F6Z555
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9796:TMEM120B
gene id: 9796:TMEM120B
uniprot id: F6X6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9796:EQUCABV1R933
gene id: 9796:EQUCABV1R933
uniprot id: A0A3Q2HPA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:CNIH4
gene id: 9796:CNIH4
uniprot id: F7CNM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9796:SLC6A9
gene id: 9796:SLC6A9
uniprot id: F7CIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9796:LOC100067502
gene id: 9796:LOC100067502
uniprot id: F6W4P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PHB
gene id: 9796:PHB
uniprot id: F6SXD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9796:ATP2A1
gene id: 9796:ATP2A1
uniprot id: A0A5F5PNX8
uniprot id: A0A5F5PZQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9796:TOMM20
gene id: 9796:TOMM20
uniprot id: F7CMK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9796:LOC102147743
gene id: 9796:LOC102147743
uniprot id: F7BWE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

9796:UBE4B
gene id: 9796:UBE4B
uniprot id: F6RP60
uniprot id: F6RQ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9796:DDI1
gene id: 9796:DDI1
uniprot id: F6SLF4
names: Similarity
messages: Belongs to the DDI1 family.

9796:NPY2R
gene id: 9796:NPY2R
uniprot id: F6X314
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:EZH2
gene id: 9796:EZH2
uniprot id: A0A3Q2IB71
uniprot id: F6WSH0
names: Subcellular Location Annotation
messages: Nucleus

9796:DKK2
gene id: 9796:DKK2
uniprot id: A0A3Q2GWS4
names: Similarity
messages: Belongs to the dickkopf family.

9796:NXPH2
gene id: 9796:NXPH2
uniprot id: F6YNK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9796:UQCC1
gene id: 9796:UQCC1
uniprot id: K9K400
names: Similarity
messages: Belongs to the CBP3 family.

9796:DAZL
gene id: 9796:DAZL
uniprot id: F6ZZT8
names: Subcellular Location Annotation
messages: Cytoplasm

9796:LOC100064468
gene id: 9796:LOC100064468
uniprot id: A0A7R8C3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:LOC100057025
gene id: 9796:LOC100057025
uniprot id: A0A3Q2HBZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:EML1
gene id: 9796:EML1
uniprot id: A0A3Q2GTT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9796:SPAST
gene id: 9796:SPAST
uniprot id: A0A3Q2HCI4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

9796:SFN
gene id: 9796:SFN
uniprot id: F7CIM1
names: Similarity
messages: Belongs to the 14-3-3 family.

9796:VSX2
gene id: 9796:VSX2
uniprot id: F6YMZ7
names: Subcellular Location Annotation
messages: Nucleus

9796:CENPN
gene id: 9796:CENPN
uniprot id: A0A5F5PMQ6
uniprot id: F6TTV5
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9796:TDO2
gene id: 9796:TDO2
uniprot id: F7CRD2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:PLAC8
gene id: 9796:PLAC8
uniprot id: F7D1W3
names: Similarity
messages: Belongs to the cornifelin family.

9796:LOC100071977
gene id: 9796:LOC100071977
uniprot id: F7CLS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SERPINA14
gene id: 9796:SERPINA14
uniprot id: D5SHI5
names: Similarity
messages: Belongs to the serpin family.

9796:COPZ1
gene id: 9796:COPZ1
uniprot id: A0A3Q2KYI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9796:SLC46A3
gene id: 9796:SLC46A3
uniprot id: A0A3Q2HZ33
uniprot id: F7AKM2
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100072099
gene id: 9796:LOC100072099
uniprot id: A0A3Q2I8P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FGB
gene id: 9796:FGB
uniprot id: F6PH38
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9796:BAP1
gene id: 9796:BAP1
uniprot id: F6TYN2
names: Similarity
messages: Belongs to the peptidase C12 family.

9796:UQCC3
gene id: 9796:UQCC3
uniprot id: F6Z6U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9796:GPR34
gene id: 9796:GPR34
uniprot id: F6X145
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:SLC25A46
gene id: 9796:SLC25A46
uniprot id: F6YP83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

9796:LOC100073108
gene id: 9796:LOC100073108
uniprot id: F7AXD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9796:LOC102149276
gene id: 9796:LOC102149276
uniprot id: F6XX53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9796:KCNC4
gene id: 9796:KCNC4
uniprot id: A0A3Q2H5M6
uniprot id: A0A3Q2HKG6
names: Subcellular Location Annotation
messages: Membrane

9796:NTRK2
gene id: 9796:NTRK2
uniprot id: F6QPZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

9796:NPY5R
gene id: 9796:NPY5R
uniprot id: F6TWY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

9796:UBL3
gene id: 9796:UBL3
uniprot id: F7D642
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:KIT
gene id: 9796:KIT
uniprot id: A8E0G5
uniprot id: F5HS93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9796:LOC100064514
gene id: 9796:LOC100064514
uniprot id: F6Z454
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DPY30
gene id: 9796:DPY30
uniprot id: F7DY89
names: Similarity
messages: Belongs to the dpy-30 family.

9796:PEMT
gene id: 9796:PEMT
uniprot id: A0A5F5Q0R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9796:BRK1
gene id: 9796:BRK1
uniprot id: F6R2A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: cytoskeleton

9796:STMN4
gene id: 9796:STMN4
uniprot id: A0A3Q2HFM9
uniprot id: A0A3Q2HNJ6
uniprot id: A0A3Q2HVA9
names: Similarity
messages: Belongs to the stathmin family.

9796:ATP2B2
gene id: 9796:ATP2B2
uniprot id: A0A3Q2L6B7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:NDUFAF4
gene id: 9796:NDUFAF4
uniprot id: F6UT45
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9796:NCK1
gene id: 9796:NCK1
uniprot id: F6WFB5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9796:ADGRD1
gene id: 9796:ADGRD1
uniprot id: A0A3Q2HIE3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:ABLIM1
gene id: 9796:ABLIM1
uniprot id: F6YVV1
names: Subcellular Location Annotation
messages: Cytoplasm

9796:GJA5
gene id: 9796:GJA5
uniprot id: F7BKC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:LBP
gene id: 9796:LBP
uniprot id: F7C0D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

9796:SNURF
gene id: 9796:SNURF
uniprot id: A0A3Q2HS10
names: Similarity
messages: Belongs to the SNURF family.

9796:MYH2
gene id: 9796:MYH2
uniprot id: Q8MJV1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction. Required for cytoskeleton organization (By similarity).
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with GCSAM.
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-2 (MYO2).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9796:PDE1C
gene id: 9796:PDE1C
uniprot id: A0A5F5PGC1
uniprot id: A0A5F5Q383
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9796:CSNK1G1
gene id: 9796:CSNK1G1
uniprot id: F7CMP4
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9796:WNT2
gene id: 9796:WNT2
uniprot id: Q2QLA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

9796:BGN
gene id: 9796:BGN
uniprot id: O46403
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity).
messages: May be involved in collagen fiber assembly.
messages: The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.
messages: extracellular matrix

9796:MKNK1
gene id: 9796:MKNK1
uniprot id: A0A3Q2IEC9
uniprot id: F6TPS7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:HUS1
gene id: 9796:HUS1
uniprot id: A0A3Q2HI31
names: Similarity
messages: Belongs to the HUS1 family.

9796:EQUCABV1R903
gene id: 9796:EQUCABV1R903
uniprot id: A0A3Q2KV06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:LOC100061806
gene id: 9796:LOC100061806
uniprot id: F6WJM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RAMP3
gene id: 9796:RAMP3
uniprot id: A0A3Q2I3B5
names: Similarity
messages: Belongs to the RAMP family.

9796:LOC100055814
gene id: 9796:LOC100055814
uniprot id: A0A5F5PUN0
names: Similarity
messages: Belongs to the LCE family.

9796:MVB12A
gene id: 9796:MVB12A
uniprot id: F6PZ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9796:METTL4
gene id: 9796:METTL4
uniprot id: A0A5F5PS09
names: Similarity
messages: Belongs to the MT-A70-like family.

9796:TNFSF13
gene id: 9796:TNFSF13
uniprot id: A0A3Q2HPH5
uniprot id: A0A3Q2HZM9
uniprot id: F2VR37
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9796:ZDHHC24
gene id: 9796:ZDHHC24
uniprot id: F6ZZE9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9796:LOC100062733
gene id: 9796:LOC100062733
uniprot id: F6YX97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100146186
gene id: 9796:LOC100146186
uniprot id: A0A5F5PUA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DNA2
gene id: 9796:DNA2
uniprot id: F6ZBQ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Mitochondrion
messages: Nucleus

9796:ACSS2
gene id: 9796:ACSS2
uniprot id: A0A3Q2H332
uniprot id: F6WY71
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9796:CETN1
gene id: 9796:CETN1
uniprot id: F6R406
names: Similarity
messages: Belongs to the centrin family.

9796:KCNQ1
gene id: 9796:KCNQ1
uniprot id: W5UPJ3
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Lateral cell membrane
messages: Membrane
messages: Membrane raft

9796:VDR
gene id: 9796:VDR
uniprot id: F6T9M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Nucleus

9796:LOC100052586
gene id: 9796:LOC100052586
uniprot id: F6QI90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9796:PAX5
gene id: 9796:PAX5
uniprot id: I3WD94
names: Subcellular Location Annotation
messages: Nucleus

9796:LGB2
gene id: 9796:LGB2
uniprot id: P07380
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
messages: Monomer.
messages: Secreted

9796:CA12
gene id: 9796:CA12
uniprot id: A5YBM0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9796:NF2
gene id: 9796:NF2
uniprot id: A0A3Q2HBA0
uniprot id: A0A3Q2HH25
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9796:AP3M1
gene id: 9796:AP3M1
uniprot id: F6VZC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9796:NMU
gene id: 9796:NMU
uniprot id: A0A3Q2HSM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9796:FAM171B
gene id: 9796:FAM171B
uniprot id: F6RNK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9796:PNLIPRP3
gene id: 9796:PNLIPRP3
uniprot id: F6RE01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9796:ETV3L
gene id: 9796:ETV3L
uniprot id: F6WKX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:PAX3
gene id: 9796:PAX3
uniprot id: F7DM34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9796:LOC100058979
gene id: 9796:LOC100058979
uniprot id: F6U9J2
uniprot id: F6ZQW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9796:LAMC2
gene id: 9796:LAMC2
uniprot id: Q8HZI9
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
messages: Binds heparin.
messages: Domain IV is globular.
messages: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-2 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein).
messages: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
messages: basement membrane

9796:AHSA1
gene id: 9796:AHSA1
uniprot id: F6UA86
names: Similarity
messages: Belongs to the AHA1 family.

9796:LOC100063976
gene id: 9796:LOC100063976
uniprot id: A0A3Q2HVS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DDX49
gene id: 9796:DDX49
uniprot id: F6RLQ4
names: Similarity
messages: Belongs to the DEAD box helicase family.

9796:LOC100146533
gene id: 9796:LOC100146533
uniprot id: F6ZRI4
names: Similarity
messages: Belongs to the PRAME family.

9796:SLC25A16
gene id: 9796:SLC25A16
uniprot id: F6SAD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:CDKN2AIPNL
gene id: 9796:CDKN2AIPNL
uniprot id: F6V183
names: Similarity
messages: Belongs to the CARF family.

9796:ATP6V0C
gene id: 9796:ATP6V0C
uniprot id: F6STX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9796:LOC100055559
gene id: 9796:LOC100055559
uniprot id: F6YXL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SLITRK1
gene id: 9796:SLITRK1
uniprot id: F6U3L1
names: Similarity
messages: Belongs to the SLITRK family.

9796:FAM161B
gene id: 9796:FAM161B
uniprot id: F6WZP9
names: Similarity
messages: Belongs to the FAM161 family.

9796:CFL1
gene id: 9796:CFL1
uniprot id: F7DXG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: lamellipodium membrane
messages: ruffle membrane

9796:FASLG
gene id: 9796:FASLG
uniprot id: F6YI29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9796:LOC100065392
gene id: 9796:LOC100065392
uniprot id: A0A3Q2HNX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9796:CYP3A93
gene id: 9796:CYP3A93
uniprot id: D7GB55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:ZC3HC1
gene id: 9796:ZC3HC1
uniprot id: F6RR49
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100068100
gene id: 9796:LOC100068100
uniprot id: F7BUG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100065589
gene id: 9796:LOC100065589
uniprot id: A0A3Q2L6I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CCKAR
gene id: 9796:CCKAR
uniprot id: F7AHW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9796:GPC3
gene id: 9796:GPC3
uniprot id: F7B944
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9796:SCN4A
gene id: 9796:SCN4A
uniprot id: Q28371
names: Activity Regulation
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily.
messages: Cell membrane
messages: Channel activity is regulated by the ancillary beta subunit SCN1B. SCN1B strongly enhances the presence of the pore-forming alpha subunit at the cell surface (By similarity). Interaction with SCN1B is required for rapid channel inactivation and rapid recovery after inactivation, and prevents decrease of channel activity in response to repetitive, high-frequency depolarizations. The channel is inhibited by tetrodotoxin (By similarity).
messages: Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits. Interacts with SCN1B (By similarity). Heterooligomer with SCN2B or SCN4B; disulfide-linked (By similarity). Interacts with the PDZ domain of the syntrophins SNTA1, SNTB1 and SNTB2 (By similarity). Interacts with the conotoxin GVIIJ (By similarity).
messages: Defects in SCN4A are the cause of periodic paralysis hyperkalemic (HYPP). HYPP is an autosomal dominant channelopathy characterized by episodic flaccid generalized muscle weakness associated with high levels of serum potassium. HYPP is frequently found in Quarter Horses, the most popular equine breed in the United States.
messages: Phosphorylation at Ser-1325 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
messages: Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states (By similarity). Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels (PubMed:1338908).
messages: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

9796:BABAM1
gene id: 9796:BABAM1
uniprot id: F6WXE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9796:CXCR4
gene id: 9796:CXCR4
uniprot id: F6Y9M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Membrane

9796:IMP3
gene id: 9796:IMP3
uniprot id: A0A3Q2GXM6
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9796:GABRA2
gene id: 9796:GABRA2
uniprot id: F6U3M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9796:ZNF18
gene id: 9796:ZNF18
uniprot id: F6SMT9
names: Subcellular Location Annotation
messages: Nucleus

9796:AURKB
gene id: 9796:AURKB
uniprot id: F7DPL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centromere

9796:LOC100069048
gene id: 9796:LOC100069048
uniprot id: F6U7B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SRSF1
gene id: 9796:SRSF1
uniprot id: F6YHN4
names: Similarity
messages: Belongs to the splicing factor SR family.

9796:TACC2
gene id: 9796:TACC2
uniprot id: A0A3Q2HMY8
uniprot id: A0A3Q2ID30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9796:TRHR
gene id: 9796:TRHR
uniprot id: F6WCI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9796:PRPF18
gene id: 9796:PRPF18
uniprot id: K9K9R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9796:DDX52
gene id: 9796:DDX52
uniprot id: F6SGX9
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9796:GORAB
gene id: 9796:GORAB
uniprot id: F7CLZ6
names: Similarity
messages: Belongs to the GORAB family.

9796:VARS2
gene id: 9796:VARS2
uniprot id: F6UGH0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9796:CALCRL
gene id: 9796:CALCRL
uniprot id: F7BDX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9796:FEN1
gene id: 9796:FEN1
uniprot id: F6RSE3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9796:LOC100054394
gene id: 9796:LOC100054394
uniprot id: F6THX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100146447
gene id: 9796:LOC100146447
uniprot id: F7DI43
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9796:ATG9A
gene id: 9796:ATG9A
uniprot id: F6UM46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9796:CASP4
gene id: 9796:CASP4
uniprot id: F6RH82
names: Similarity
messages: Belongs to the peptidase C14A family.

9796:GPX8
gene id: 9796:GPX8
uniprot id: F6U5X9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9796:LOC100050034
gene id: 9796:LOC100050034
uniprot id: F7CQ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9796:GDPD2
gene id: 9796:GDPD2
uniprot id: F6UF92
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9796:LOC100065500
gene id: 9796:LOC100065500
uniprot id: F6UMA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TMEM200A
gene id: 9796:TMEM200A
uniprot id: F7DA31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9796:ATP6AP2
gene id: 9796:ATP6AP2
uniprot id: K9K9G6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9796:LOC100059683
gene id: 9796:LOC100059683
uniprot id: A0A3Q2LEL7
names: Similarity
messages: Belongs to the folate receptor family.

9796:GLG1
gene id: 9796:GLG1
uniprot id: A0A3Q2IBB5
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

9796:BLVRA
gene id: 9796:BLVRA
uniprot id: K9K3J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

9796:EIF3D
gene id: 9796:EIF3D
uniprot id: F6VVG6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9796:UQCRC2
gene id: 9796:UQCRC2
uniprot id: F6QA35
names: Similarity
messages: Belongs to the peptidase M16 family.

9796:PSMC1
gene id: 9796:PSMC1
uniprot id: F6WJB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9796:AP5M1
gene id: 9796:AP5M1
uniprot id: A0A3Q2GV64
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9796:FAM126B
gene id: 9796:FAM126B
uniprot id: A0A3Q2HXI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9796:TMEM167B
gene id: 9796:TMEM167B
uniprot id: F7AI96
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:SGK1
gene id: 9796:SGK1
uniprot id: A0A3Q2HY27
uniprot id: F7BY67
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:DDX59
gene id: 9796:DDX59
uniprot id: F7CSK5
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

9796:KRT24
gene id: 9796:KRT24
uniprot id: F6W8W3
names: Similarity
messages: Belongs to the intermediate filament family.

9796:NPVF
gene id: 9796:NPVF
uniprot id: F6W416
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9796:CCDC167
gene id: 9796:CCDC167
uniprot id: A0A5F5Q106
names: Subcellular Location Annotation
messages: Membrane

9796:SDR42E1
gene id: 9796:SDR42E1
uniprot id: F7B719
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9796:POU4F2
gene id: 9796:POU4F2
uniprot id: F6U8H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9796:UVSSA
gene id: 9796:UVSSA
uniprot id: F6RPP3
names: Similarity
messages: Belongs to the UVSSA family.

9796:RFC4
gene id: 9796:RFC4
uniprot id: F6VV49
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9796:MICAL1
gene id: 9796:MICAL1
uniprot id: F7DYV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9796:SNRPF
gene id: 9796:SNRPF
uniprot id: F7CC29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9796:PLAG1
gene id: 9796:PLAG1
uniprot id: F6PTT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9796:ADD2
gene id: 9796:ADD2
uniprot id: F6RXJ0
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9796:DCSTAMP
gene id: 9796:DCSTAMP
uniprot id: F7AUM8
names: Subcellular Location Annotation
messages: Membrane

9796:EMC1
gene id: 9796:EMC1
uniprot id: F6U072
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:PARL
gene id: 9796:PARL
uniprot id: A0A5F5PGE3
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100068042
gene id: 9796:LOC100068042
uniprot id: F7CGL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MRPS7
gene id: 9796:MRPS7
uniprot id: F6XZF2
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9796:TUBG2
gene id: 9796:TUBG2
uniprot id: F6RCT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9796:COX15
gene id: 9796:COX15
uniprot id: F7ANX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9796:NPPB
gene id: 9796:NPPB
uniprot id: F6ZWP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.
messages: Secreted

9796:OSBPL11
gene id: 9796:OSBPL11
uniprot id: F6UUN5
names: Similarity
messages: Belongs to the OSBP family.

9796:KHDRBS2
gene id: 9796:KHDRBS2
uniprot id: F6Q1D7
names: Similarity
messages: Belongs to the KHDRBS family.

9796:PRLR
gene id: 9796:PRLR
uniprot id: F6Z164
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9796:LY49E
gene id: 9796:LY49E
uniprot id: Q75XR4
names: Subcellular Location Annotation
messages: Membrane

9796:CAPZA2
gene id: 9796:CAPZA2
uniprot id: Q2QLA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity).

9796:EDNRA
gene id: 9796:EDNRA
uniprot id: A0A3Q2HSI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9796:PLPPR1
gene id: 9796:PLPPR1
uniprot id: A0A3Q2ILT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

9796:YWHAE
gene id: 9796:YWHAE
uniprot id: A0A5F5PYF1
names: Similarity
messages: Belongs to the 14-3-3 family.

9796:CNPY2
gene id: 9796:CNPY2
uniprot id: F7DEN7
names: Similarity
messages: Belongs to the canopy family.

9796:GPRIN2
gene id: 9796:GPRIN2
uniprot id: F7AZG0
names: Function
messages: May be involved in neurite outgrowth.

9796:GRB10
gene id: 9796:GRB10
uniprot id: A0A3Q2I8Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9796:IFNA1
gene id: 9796:IFNA1
uniprot id: P05005
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
messages: Secreted

9796:LOC100049818
gene id: 9796:LOC100049818
uniprot id: A0A3Q2L811
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:PTGER4
gene id: 9796:PTGER4
uniprot id: F6ZUH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9796:LAP3
gene id: 9796:LAP3
uniprot id: F7A676
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9796:TBL3
gene id: 9796:TBL3
uniprot id: F7D8A4
names: Subcellular Location Annotation
messages: nucleolus

9796:XCL1
gene id: 9796:XCL1
uniprot id: F7AEZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Belongs to the intercrine gamma family.
messages: Secreted

9796:CFL2
gene id: 9796:CFL2
uniprot id: F7CT91
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9796:HDX
gene id: 9796:HDX
uniprot id: A0A3Q2HLI7
names: Subcellular Location Annotation
messages: Nucleus

9796:TMSB4X
gene id: 9796:TMSB4X
uniprot id: P62327
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AcSDKP is inactivated by ACE, which removes the dipeptide Lys-Pro from its C-terminus.
messages: Belongs to the thymosin beta family.
messages: Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with SERPINB1 (By similarity).
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: Potent inhibitor of bone marrow derived stem cell differentiation (By similarity). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).
messages: cytoskeleton

9796:TMEM225
gene id: 9796:TMEM225
uniprot id: F6UIT8
names: Subcellular Location Annotation
messages: Membrane

9796:RPF2
gene id: 9796:RPF2
uniprot id: A0A3Q2HHL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

9796:TGIF2
gene id: 9796:TGIF2
uniprot id: A0A3Q2HHM0
names: Subcellular Location Annotation
messages: Nucleus

9796:NGB
gene id: 9796:NGB
uniprot id: A0A3Q2HPU5
names: Similarity
messages: Belongs to the globin family.

9796:RPS28
gene id: 9796:RPS28
uniprot id: F6WVD1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the 40S small ribosomal subunit.

9796:ETV6
gene id: 9796:ETV6
uniprot id: A0A3Q2L532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:PLXNB3
gene id: 9796:PLXNB3
uniprot id: F6VYW6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:VWF
gene id: 9796:VWF
uniprot id: A0A061DBP6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
messages: Multimeric. Interacts with F8.
messages: Secreted
messages: extracellular matrix

9796:IBSP
gene id: 9796:IBSP
uniprot id: F6YPI2
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9796:SEC61B
gene id: 9796:SEC61B
uniprot id: F6RA60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9796:TAF15
gene id: 9796:TAF15
uniprot id: F7DSE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9796:DNAL4
gene id: 9796:DNAL4
uniprot id: A0A5F5PHK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9796:COPS8
gene id: 9796:COPS8
uniprot id: F7B7G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9796:ABL2
gene id: 9796:ABL2
uniprot id: F7B6Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9796:MLH1
gene id: 9796:MLH1
uniprot id: F6YSI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9796:CREB1
gene id: 9796:CREB1
uniprot id: A0A3Q2HGQ8
uniprot id: F7ALB5
uniprot id: I3WD93
names: Subcellular Location Annotation
messages: Nucleus

9796:AGPAT4
gene id: 9796:AGPAT4
uniprot id: A0A3Q2LC06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9796:NCAPH
gene id: 9796:NCAPH
uniprot id: A0A3Q2HVC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

9796:BSP2
gene id: 9796:BSP2
uniprot id: Q70GG5
names: Caution
names: Similarity
messages: Belongs to the seminal plasma protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:APLNR
gene id: 9796:APLNR
uniprot id: F6QWW0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:CLDN19
gene id: 9796:CLDN19
uniprot id: F6RGA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:ALG3
gene id: 9796:ALG3
uniprot id: F6PIM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:NCDN
gene id: 9796:NCDN
uniprot id: A0A3Q2HRX0
uniprot id: F6Q1Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

9796:MEF2C
gene id: 9796:MEF2C
uniprot id: A0A3Q2GZP7
uniprot id: A0A3Q2IEL4
uniprot id: A0A3Q2KSF1
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100064358
gene id: 9796:LOC100064358
uniprot id: A0A3Q2I4I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CLEC12A
gene id: 9796:CLEC12A
uniprot id: A0A3Q2GYH6
uniprot id: A0A3Q2I597
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:LOC100073305
gene id: 9796:LOC100073305
uniprot id: F6TCC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9796:THRSP
gene id: 9796:THRSP
uniprot id: F7AMU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9796:AVPR1B
gene id: 9796:AVPR1B
uniprot id: F7BNU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9796:TRNT1
gene id: 9796:TRNT1
uniprot id: F7CNA6
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9796:THRB
gene id: 9796:THRB
uniprot id: F7E341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9796:ZNF449
gene id: 9796:ZNF449
uniprot id: F6YM96
names: Subcellular Location Annotation
messages: Nucleus

9796:ARSK
gene id: 9796:ARSK
uniprot id: F6PQA7
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9796:CSAD
gene id: 9796:CSAD
uniprot id: A0A3Q2HWH1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9796:ENO3
gene id: 9796:ENO3
uniprot id: F7C959
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9796:SNX20
gene id: 9796:SNX20
uniprot id: A0A3Q2L3E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9796:EQMHCB2
gene id: 9796:EQMHCB2
uniprot id: Q38RB9
names: Similarity
messages: Belongs to the MHC class I family.

9796:UBXN1
gene id: 9796:UBXN1
uniprot id: F6S4B7
names: Subcellular Location Annotation
messages: Cytoplasm

9796:PLBD1
gene id: 9796:PLBD1
uniprot id: F7D2U1
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9796:RNF152
gene id: 9796:RNF152
uniprot id: F7B6P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

9796:DECR2
gene id: 9796:DECR2
uniprot id: F6RNB0
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

9796:KCNJ16
gene id: 9796:KCNJ16
uniprot id: F6W519
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9796:IDNK
gene id: 9796:IDNK
uniprot id: A0A3Q2HI60
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

9796:SEPT11
gene id: 9796:SEPT11
uniprot id: A0A3Q2LM93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9796:SLC5A4
gene id: 9796:SLC5A4
uniprot id: F6XI49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9796:LOC100070660
gene id: 9796:LOC100070660
uniprot id: F7A6P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MRPS10
gene id: 9796:MRPS10
uniprot id: A0A3Q2I3Q3
uniprot id: F7D150
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9796:LMBR1L
gene id: 9796:LMBR1L
uniprot id: F7AR89
names: Similarity
messages: Belongs to the LIMR family.

9796:CDK3
gene id: 9796:CDK3
uniprot id: F6W389
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:VDAC3
gene id: 9796:VDAC3
uniprot id: F7DT77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

9796:CDC42SE1
gene id: 9796:CDC42SE1
uniprot id: F6YQ69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9796:LLPH
gene id: 9796:LLPH
uniprot id: F7AN66
names: Similarity
messages: Belongs to the learning-associated protein family.

9796:LOC100052658
gene id: 9796:LOC100052658
uniprot id: A0A7R8C3U8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family.
messages: Monomer.
messages: Secreted

9796:IL21
gene id: 9796:IL21
uniprot id: A0A3Q2GUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9796:CYBA
gene id: 9796:CYBA
uniprot id: F7DB64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9796:AMPD1
gene id: 9796:AMPD1
uniprot id: F7DRI4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9796:SLC29A3
gene id: 9796:SLC29A3
uniprot id: A0A5F5PQF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9796:LARS
gene id: 9796:LARS
uniprot id: F6YTK4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9796:SAR1A
gene id: 9796:SAR1A
uniprot id: F7BD89
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9796:RPL27
gene id: 9796:RPL27
uniprot id: F7D8K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9796:C3H16orf70
gene id: 9796:C3H16orf70
uniprot id: A0A3Q2L6G1
uniprot id: F7BK96
names: Similarity
messages: Belongs to the PHAF1 family.

9796:PGGT1B
gene id: 9796:PGGT1B
uniprot id: F6W1R0
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9796:CDIPT
gene id: 9796:CDIPT
uniprot id: F6SE67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9796:RNF182
gene id: 9796:RNF182
uniprot id: F6VH97
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9796:NEURL2
gene id: 9796:NEURL2
uniprot id: F6TT21
names: Subcellular Location Annotation
messages: Cytoplasm

9796:KARS
gene id: 9796:KARS
uniprot id: A0A5F5PL33
uniprot id: F6ZYC2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9796:LOC100058795
gene id: 9796:LOC100058795
uniprot id: F6QB81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RTN4IP1
gene id: 9796:RTN4IP1
uniprot id: A0A3Q2I8D0
uniprot id: A0A3Q2LLK9
uniprot id: F6ZDF5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9796:LOC100071802
gene id: 9796:LOC100071802
uniprot id: F7D2M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LDHB
gene id: 9796:LDHB
uniprot id: B7XH74
uniprot id: C6L1J5
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9796:LYZL4
gene id: 9796:LYZL4
uniprot id: F6ZMI7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9796:TNS4
gene id: 9796:TNS4
uniprot id: F6VZB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9796:EQUCABV1R906
gene id: 9796:EQUCABV1R906
uniprot id: A0A3Q2HLF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:DCP1A
gene id: 9796:DCP1A
uniprot id: F6SI49
names: Similarity
messages: Belongs to the DCP1 family.

9796:DSG4
gene id: 9796:DSG4
uniprot id: F7CMD3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9796:TMEM126B
gene id: 9796:TMEM126B
uniprot id: F7DQN7
names: Subcellular Location Annotation
messages: Membrane

9796:TFB2M
gene id: 9796:TFB2M
uniprot id: F6XCH2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

9796:HS3ST3B1
gene id: 9796:HS3ST3B1
uniprot id: F6SM40
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:HNRNPH2
gene id: 9796:HNRNPH2
uniprot id: F6UAN2
names: Subcellular Location Annotation
messages: nucleoplasm

9796:FAM198B
gene id: 9796:FAM198B
uniprot id: F6WNX8
names: Similarity
messages: Belongs to the GASK family.

9796:TIMM17A
gene id: 9796:TIMM17A
uniprot id: F6X4V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9796:RPS14
gene id: 9796:RPS14
uniprot id: F6XLM5
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9796:IFI44
gene id: 9796:IFI44
uniprot id: F6R7P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI44 family.
messages: Cytoplasm

9796:TACO1
gene id: 9796:TACO1
uniprot id: F7DJS0
names: Similarity
messages: Belongs to the TACO1 family.

9796:RPS2
gene id: 9796:RPS2
uniprot id: F6Y739
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.

9796:MRPL34
gene id: 9796:MRPL34
uniprot id: F7B9W7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

9796:ACVR2A
gene id: 9796:ACVR2A
uniprot id: F7CD19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9796:CADM1
gene id: 9796:CADM1
uniprot id: A0A3Q2HKL3
uniprot id: A0A3Q2IAC8
uniprot id: A0A5F5PGJ5
uniprot id: A0A5F5PQK7
uniprot id: A0A5F5Q191
names: Similarity
messages: Belongs to the nectin family.

9796:MMACHC
gene id: 9796:MMACHC
uniprot id: F6U012
names: Similarity
messages: Belongs to the MMACHC family.

9796:HMGCL
gene id: 9796:HMGCL
uniprot id: A0A3Q2HV64
uniprot id: F6Q4C8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9796:BMP10
gene id: 9796:BMP10
uniprot id: F7DLP6
names: Similarity
messages: Belongs to the TGF-beta family.

9796:CCR9
gene id: 9796:CCR9
uniprot id: F6X7N4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:CMTM2
gene id: 9796:CMTM2
uniprot id: F6TWG9
names: Subcellular Location Annotation
messages: Membrane

9796:ILVBL
gene id: 9796:ILVBL
uniprot id: F6QMZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

9796:LOC100059149
gene id: 9796:LOC100059149
uniprot id: F6X3Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9796:UNK
gene id: 9796:UNK
uniprot id: A0A3Q2HGF1
uniprot id: F6SJ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9796:STOM
gene id: 9796:STOM
uniprot id: F6RA08
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9796:PSMC3IP
gene id: 9796:PSMC3IP
uniprot id: F7BQN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9796:ADD1
gene id: 9796:ADD1
uniprot id: A0A3Q2H191
uniprot id: A0A3Q2I4E0
uniprot id: F7AM06
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9796:ANP32E
gene id: 9796:ANP32E
uniprot id: A0A3Q2HZU7
uniprot id: A0A5F5PWG1
names: Similarity
messages: Belongs to the ANP32 family.

9796:ISM1
gene id: 9796:ISM1
uniprot id: F6SEI0
names: Similarity
messages: Belongs to the isthmin family.

9796:HBB
gene id: 9796:HBB
uniprot id: A0A1K0FUE2
names: Similarity
messages: Belongs to the globin family.

9796:RAD17
gene id: 9796:RAD17
uniprot id: F7AF89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9796:PIGH
gene id: 9796:PIGH
uniprot id: F7DTY1
names: Similarity
messages: Belongs to the PIGH family.

9796:LOC102150222
gene id: 9796:LOC102150222
uniprot id: F6ZNY8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9796:SEMA3G
gene id: 9796:SEMA3G
uniprot id: F6ZCL2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:IL12RB2
gene id: 9796:IL12RB2
uniprot id: A0A3Q2GWE9
uniprot id: F6YRY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9796:UBE2L6
gene id: 9796:UBE2L6
uniprot id: A0A3Q2ICB2
uniprot id: F6QT00
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9796:LOC106780854
gene id: 9796:LOC106780854
uniprot id: A0A3Q2I0W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LHFPL5
gene id: 9796:LHFPL5
uniprot id: F7BGZ4
names: Subcellular Location Annotation
messages: Membrane

9796:KCNH2
gene id: 9796:KCNH2
uniprot id: E0ADY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
messages: Membrane

9796:CLEC18B
gene id: 9796:CLEC18B
uniprot id: A0A3Q2HE14
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:PDLIM1
gene id: 9796:PDLIM1
uniprot id: F6U592
names: Subcellular Location Annotation
messages: Z line

9796:CD247
gene id: 9796:CD247
uniprot id: F7DH49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9796:ATP2B3
gene id: 9796:ATP2B3
uniprot id: A0A3Q2I1T2
uniprot id: A0A3Q2L586
uniprot id: F6Y6Q6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:CLVS2
gene id: 9796:CLVS2
uniprot id: F6ZKU2
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9796:VEGFA
gene id: 9796:VEGFA
uniprot id: Q9GKR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (By similarity). Interacts with BSG (By similarity).
messages: Secreted

9796:HS3ST1
gene id: 9796:HS3ST1
uniprot id: F6VH42
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:LOC100049859
gene id: 9796:LOC100049859
uniprot id: F6YTA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9796:LOC100050322
gene id: 9796:LOC100050322
uniprot id: F7DZD2
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9796:IGF2R
gene id: 9796:IGF2R
uniprot id: F6VWA8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:ZBED9
gene id: 9796:ZBED9
uniprot id: F6S057
names: Subcellular Location Annotation
messages: Nucleus

9796:MYOC
gene id: 9796:MYOC
uniprot id: F6QKR7
names: Caution
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion outer membrane
messages: Rough endoplasmic reticulum
messages: cilium
messages: extracellular exosome
messages: extracellular matrix

9796:SERPINF1
gene id: 9796:SERPINF1
uniprot id: B8K250
names: Similarity
messages: Belongs to the serpin family.

9796:MUT
gene id: 9796:MUT
uniprot id: F6V4C7
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

9796:ATG13
gene id: 9796:ATG13
uniprot id: A0A5F5PX34
uniprot id: F6QAI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9796:RABGGTB
gene id: 9796:RABGGTB
uniprot id: F7C914
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9796:CX3CR1
gene id: 9796:CX3CR1
uniprot id: A0A3Q2LEC3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9796:LOC100063722
gene id: 9796:LOC100063722
uniprot id: F7D4Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9796:LSM3
gene id: 9796:LSM3
uniprot id: F7CEU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9796:ARPP19
gene id: 9796:ARPP19
uniprot id: A0A5K1UUV5
uniprot id: F7DHQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9796:METAP2
gene id: 9796:METAP2
uniprot id: A0A3Q2HPK6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9796:UBE2U
gene id: 9796:UBE2U
uniprot id: A0A3Q2GXC2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9796:DPT
gene id: 9796:DPT
uniprot id: F6T2K8
names: Similarity
messages: Belongs to the dermatopontin family.

9796:ADD3
gene id: 9796:ADD3
uniprot id: A0A3Q2LG18
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9796:SLC1A3
gene id: 9796:SLC1A3
uniprot id: F7CMW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9796:PDS5A
gene id: 9796:PDS5A
uniprot id: F6QVB8
names: Similarity
messages: Belongs to the PDS5 family.

9796:CTNS
gene id: 9796:CTNS
uniprot id: F6YJV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9796:SULT1C4
gene id: 9796:SULT1C4
uniprot id: F6WZG9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:BZW2
gene id: 9796:BZW2
uniprot id: A0A3Q2L579
names: Similarity
messages: Belongs to the BZW family.

9796:VEGFD
gene id: 9796:VEGFD
uniprot id: A0A3Q2HIS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9796:LYG2
gene id: 9796:LYG2
uniprot id: F7BRJ1
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9796:PIP4P1
gene id: 9796:PIP4P1
uniprot id: F7DBD6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9796:LGI1
gene id: 9796:LGI1
uniprot id: F6QPB4
names: Subcellular Location Annotation
messages: Secreted

9796:TSPAN5
gene id: 9796:TSPAN5
uniprot id: F7AND6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9796:SLC5A2
gene id: 9796:SLC5A2
uniprot id: F6S4E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9796:LOC100050637
gene id: 9796:LOC100050637
uniprot id: A0A3Q2HBD5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9796:NUBP1
gene id: 9796:NUBP1
uniprot id: F6T7P0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9796:LCA5
gene id: 9796:LCA5
uniprot id: F6TRR5
names: Similarity
messages: Belongs to the LCA5 family.

9796:LOC100066263
gene id: 9796:LOC100066263
uniprot id: F6YHX0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MTIF3
gene id: 9796:MTIF3
uniprot id: F6X1C9
names: Similarity
messages: Belongs to the IF-3 family.

9796:EMG1
gene id: 9796:EMG1
uniprot id: F7BKD4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9796:KEF40 p07
gene id: 9796:KEF40_p07
uniprot id: P48661
uniprot id: Q6J6W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9796:ATP5PO
gene id: 9796:ATP5PO
uniprot id: F6WLI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9796:INSIG1
gene id: 9796:INSIG1
uniprot id: A0A3Q2HPQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9796:MAT1A
gene id: 9796:MAT1A
uniprot id: F6S3W6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9796:GATB
gene id: 9796:GATB
uniprot id: A0A3Q2I4T3
uniprot id: F6SQG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9796:HCCS
gene id: 9796:HCCS
uniprot id: A0A3Q2II97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9796:C9H8orf37
gene id: 9796:C9H8orf37
uniprot id: F6UB70
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9796:CFTR
gene id: 9796:CFTR
uniprot id: Q2QLA3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).
messages: N-glycosylated.
messages: Nucleus
messages: Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.
messages: Recycling endosome membrane
messages: The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.
messages: The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.
messages: Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity).

9796:CENPH
gene id: 9796:CENPH
uniprot id: F6PLT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9796:TNR
gene id: 9796:TNR
uniprot id: F7A2I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9796:COG3
gene id: 9796:COG3
uniprot id: F6QWN5
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9796:FOPNL
gene id: 9796:FOPNL
uniprot id: A0A5F5PJW8
uniprot id: F6Z319
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9796:SNRPG
gene id: 9796:SNRPG
uniprot id: A0A5F5PUN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9796:B9D2
gene id: 9796:B9D2
uniprot id: F6VF72
names: Subcellular Location Annotation
messages: cilium basal body

9796:LOC100054453
gene id: 9796:LOC100054453
uniprot id: F6WX19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:XKRX
gene id: 9796:XKRX
uniprot id: F7A7H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9796:LOC100055944
gene id: 9796:LOC100055944
uniprot id: F7AMR9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PRKAA2
gene id: 9796:PRKAA2
uniprot id: Q2LGF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm

9796:CCT6B
gene id: 9796:CCT6B
uniprot id: F6YEJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9796:SUPT5H
gene id: 9796:SUPT5H
uniprot id: A0A3Q2HQ12
uniprot id: A0A3Q2HTG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9796:FTH1
gene id: 9796:FTH1
uniprot id: Q8MIP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

9796:INSIG2
gene id: 9796:INSIG2
uniprot id: F6V608
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9796:SMIM18
gene id: 9796:SMIM18
uniprot id: A0A3Q2HWP5
names: Subcellular Location Annotation
messages: Membrane

9796:TPRG1
gene id: 9796:TPRG1
uniprot id: F6T3N4
names: Similarity
messages: Belongs to the TPRG1 family.

9796:BDKRB1
gene id: 9796:BDKRB1
uniprot id: F7CTN3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9796:CAB39L
gene id: 9796:CAB39L
uniprot id: K9K392
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9796:HEXDC
gene id: 9796:HEXDC
uniprot id: F7CT58
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

9796:USB1
gene id: 9796:USB1
uniprot id: A0A5F5PYX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9796:LOC100065786
gene id: 9796:LOC100065786
uniprot id: F6PQD3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9796:PPIP5K2
gene id: 9796:PPIP5K2
uniprot id: F6WMW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9796:C13H16orf71
gene id: 9796:C13H16orf71
uniprot id: F7D342
names: Function
messages: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.

9796:FAM32A
gene id: 9796:FAM32A
uniprot id: F6S423
names: Similarity
messages: Belongs to the FAM32 family.

9796:CILP
gene id: 9796:CILP
uniprot id: F7C2J3
names: Subcellular Location Annotation
messages: extracellular matrix

9796:ADGRG6
gene id: 9796:ADGRG6
uniprot id: A0A3Q2LQQ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:TLR7
gene id: 9796:TLR7
uniprot id: A0A3Q2KNZ7
uniprot id: A1XC20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane
messages: phagosome

9796:ACE
gene id: 9796:ACE
uniprot id: F6ZSR4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 2 Zn(2+) ions per subunit.

9796:EBP
gene id: 9796:EBP
uniprot id: F6YVN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:KDM5C
gene id: 9796:KDM5C
uniprot id: F6RKS3
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9796:MPPED2
gene id: 9796:MPPED2
uniprot id: F7DY29
names: Similarity
messages: Belongs to the UPF0046 family.

9796:LOC100050355
gene id: 9796:LOC100050355
uniprot id: F6WKP5
names: Similarity
messages: Belongs to the peptidase C12 family.

9796:BAMBI
gene id: 9796:BAMBI
uniprot id: F6X7H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9796:LOC100071258
gene id: 9796:LOC100071258
uniprot id: A0A3Q2H2M5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TAF1
gene id: 9796:TAF1
uniprot id: F7DCN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

9796:NPR3
gene id: 9796:NPR3
uniprot id: F7DBN8
names: Subcellular Location Annotation
messages: Membrane

9796:TLR3
gene id: 9796:TLR3
uniprot id: A0ENH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9796:CAMK1G
gene id: 9796:CAMK1G
uniprot id: F7DNG7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:LOC100068248
gene id: 9796:LOC100068248
uniprot id: F6UPV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:KXD1
gene id: 9796:KXD1
uniprot id: F7E3P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9796:MIOS
gene id: 9796:MIOS
uniprot id: F6WKN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9796:ITGAX
gene id: 9796:ITGAX
uniprot id: B0F6U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9796:NKIRAS2
gene id: 9796:NKIRAS2
uniprot id: F6R224
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9796:EXOC3
gene id: 9796:EXOC3
uniprot id: F6QLI1
names: Similarity
messages: Belongs to the SEC6 family.

9796:PDIK1L
gene id: 9796:PDIK1L
uniprot id: F6WIE1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:OLFM4
gene id: 9796:OLFM4
uniprot id: A0A3Q2I574
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:CPT2
gene id: 9796:CPT2
uniprot id: F6XKH9
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9796:TAGLN3
gene id: 9796:TAGLN3
uniprot id: F6ZBC3
names: Similarity
messages: Belongs to the calponin family.

9796:ACTL6B
gene id: 9796:ACTL6B
uniprot id: F7DMS1
names: Similarity
messages: Belongs to the actin family.

9796:LTB
gene id: 9796:LTB
uniprot id: F6VWT0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9796:ATAD1
gene id: 9796:ATAD1
uniprot id: F7CB43
names: Similarity
messages: Belongs to the AAA ATPase family.

9796:LOC100057798
gene id: 9796:LOC100057798
uniprot id: F7ABR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TMEM211
gene id: 9796:TMEM211
uniprot id: F7AR42
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100053897
gene id: 9796:LOC100053897
uniprot id: F7CMF9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:LOC100072213
gene id: 9796:LOC100072213
uniprot id: A0A3Q2I5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100059576
gene id: 9796:LOC100059576
uniprot id: F7BSB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9796:NUDT1
gene id: 9796:NUDT1
uniprot id: F6Y6B8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

9796:LOC100053832
gene id: 9796:LOC100053832
uniprot id: F6VHB8
names: Similarity
messages: Belongs to the KRTAP type 3 family.

9796:PLD3
gene id: 9796:PLD3
uniprot id: F6ZRU5
names: Similarity
messages: Belongs to the phospholipase D family.

9796:MANEA
gene id: 9796:MANEA
uniprot id: F6RHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:LOC100146200
gene id: 9796:LOC100146200
uniprot id: F7DB03
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FAM129A
gene id: 9796:FAM129A
uniprot id: F7BTK9
names: Similarity
messages: Belongs to the Niban family.

9796:TMEM167A
gene id: 9796:TMEM167A
uniprot id: L7MSG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

9796:GALNT1
gene id: 9796:GALNT1
uniprot id: F7BR14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9796:TRUB2
gene id: 9796:TRUB2
uniprot id: F7CQF3
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9796:SPC25
gene id: 9796:SPC25
uniprot id: F6SDF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9796:LOC100072616
gene id: 9796:LOC100072616
uniprot id: A0A5F5PGC0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PPP4R2
gene id: 9796:PPP4R2
uniprot id: A0A3Q2LHD1
names: Similarity
messages: Belongs to the PPP4R2 family.

9796:SLC11A1
gene id: 9796:SLC11A1
uniprot id: Q95N75
names: Function
names: Similarity
messages: Belongs to the NRAMP family.
messages: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

9796:MAST4
gene id: 9796:MAST4
uniprot id: A0A3Q2KTK6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9796:LOC100053497
gene id: 9796:LOC100053497
uniprot id: F7CW05
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100051036
gene id: 9796:LOC100051036
uniprot id: Q8MIP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

9796:UNC93A
gene id: 9796:UNC93A
uniprot id: F6SCS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9796:TREX2
gene id: 9796:TREX2
uniprot id: F6UKI1
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9796:TM4SF20
gene id: 9796:TM4SF20
uniprot id: F6S942
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9796:LMOD1
gene id: 9796:LMOD1
uniprot id: F6Y249
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9796:ATP7A
gene id: 9796:ATP7A
uniprot id: F6S3X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9796:FAM168B
gene id: 9796:FAM168B
uniprot id: A0A3Q2HSE6
names: Similarity
messages: Belongs to the FAM168 family.

9796:ATRAID
gene id: 9796:ATRAID
uniprot id: A0A5F5Q2R6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:MARK2
gene id: 9796:MARK2
uniprot id: A0A3Q2H4U4
uniprot id: F6YPV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9796:CHST8
gene id: 9796:CHST8
uniprot id: F6W4B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:LOC100072073
gene id: 9796:LOC100072073
uniprot id: F7D0K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GNL2
gene id: 9796:GNL2
uniprot id: F6TYL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9796:EEF2K
gene id: 9796:EEF2K
uniprot id: F6T489
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9796:FAM57B
gene id: 9796:FAM57B
uniprot id: F6Y1P8
names: Subcellular Location Annotation
messages: Membrane

9796:TBX19
gene id: 9796:TBX19
uniprot id: A0A5F5PTJ6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9796:SDHC
gene id: 9796:SDHC
uniprot id: A0A5F5PEQ5
uniprot id: F7D5F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9796:ESRP1
gene id: 9796:ESRP1
uniprot id: A0A3Q2KPB7
uniprot id: A0A5F5Q3J9
uniprot id: F7DV79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus

9796:MSANTD3
gene id: 9796:MSANTD3
uniprot id: F6UBS3
names: Similarity
messages: Belongs to the MSANTD3 family.

9796:SRPRB
gene id: 9796:SRPRB
uniprot id: A0A3Q2ICY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:TFB1M
gene id: 9796:TFB1M
uniprot id: F6W4I0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9796:LOC100068895
gene id: 9796:LOC100068895
uniprot id: A0A1K0FUK6
names: Similarity
messages: Belongs to the globin family.

9796:DLK2
gene id: 9796:DLK2
uniprot id: F6U2R6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:PPEF2
gene id: 9796:PPEF2
uniprot id: A0A5F5PYG8
names: Similarity
messages: Belongs to the PPP phosphatase family.

9796:LY49B
gene id: 9796:LY49B
uniprot id: Q75XS1
names: Subcellular Location Annotation
messages: Membrane

9796:GALNT5
gene id: 9796:GALNT5
uniprot id: F6SIR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9796:CAPN3
gene id: 9796:CAPN3
uniprot id: A0A3Q2LR15
uniprot id: A0A5F5Q268
uniprot id: F6RX57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9796:UTS2B
gene id: 9796:UTS2B
uniprot id: A0A5F5PHA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9796:MASP2
gene id: 9796:MASP2
uniprot id: A0A5F5PVA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:GK2
gene id: 9796:GK2
uniprot id: F6UEE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9796:ATRX
gene id: 9796:ATRX
uniprot id: A0A3Q2GTI6
uniprot id: A0A3Q2GZL8
uniprot id: A0A3Q2HH61
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9796:BRPF1
gene id: 9796:BRPF1
uniprot id: F6U463
names: Subcellular Location Annotation
messages: Nucleus

9796:SNX17
gene id: 9796:SNX17
uniprot id: F6XSD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9796:S100A8
gene id: 9796:S100A8
uniprot id: F6SN37
names: Similarity
messages: Belongs to the S-100 family.

9796:IL10
gene id: 9796:IL10
uniprot id: B1AB84
uniprot id: Q28374
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-10 family.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Immune regulatory cytokine.
messages: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
messages: Secreted

9796:HOXB1
gene id: 9796:HOXB1
uniprot id: F7BMD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9796:PDSS2
gene id: 9796:PDSS2
uniprot id: A0A3Q2LJH9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9796:LGALS3BP
gene id: 9796:LGALS3BP
uniprot id: A0A3Q2I8H8
names: Function
names: Subcellular Location Annotation
messages: Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
messages: extracellular matrix

9796:POPDC2
gene id: 9796:POPDC2
uniprot id: F6R7A8
names: Similarity
messages: Belongs to the popeye family.

9796:LOC100052508
gene id: 9796:LOC100052508
uniprot id: F6T6A5
names: Similarity
messages: Belongs to the 2-5A synthase family.

9796:LOC100068669
gene id: 9796:LOC100068669
uniprot id: F6VSH0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100629936
gene id: 9796:LOC100629936
uniprot id: F6WF42
names: Subcellular Location Annotation
messages: Secreted

9796:GRWD1
gene id: 9796:GRWD1
uniprot id: F7CC43
names: Subcellular Location Annotation
messages: Nucleus

9796:HAO1
gene id: 9796:HAO1
uniprot id: F6QEA9
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9796:VPS18
gene id: 9796:VPS18
uniprot id: F6XQ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9796:WARS
gene id: 9796:WARS
uniprot id: A0A3Q2KTL8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9796:LZTS2
gene id: 9796:LZTS2
uniprot id: F6ZIR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

9796:ESR1
gene id: 9796:ESR1
uniprot id: Q9TV98
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with coactivator NCOA5. Interacts with PELP1, the interaction is enhanced by 17-beta-estradiol; the interaction increases ESR1 transcriptional activity (By similarity). Interacts with NCOA7; the interaction is ligand-inducible. Interacts with AKAP13, CUEDC2, HEXIM1, KDM5A, MAP1S, SMARD1, and UBE1C. Interacts with MUC1; the interaction is stimulated by 7 beta-estradiol (E2) and enhances ESR1-mediated transcription. Interacts with DNTTIP2, and UIMC1. Interacts with KMT2D/MLL2. Interacts with ATAD2; the interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via its C-terminus). Interacts with MACROD1. Interacts with SH2D4A and PLCG. Interacts with SH2D4A; the interaction blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62; the interaction requires estradiol and appears to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with DNAAF4. Interacts with PRMT2. Interacts with RBFOX2. Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent. Interacts with FAM120B, FOXL2, PHB2 and SLC30A9. Interacts with coactivators NCOA3 and NCOA6. Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D. Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy. Interacts with DDX5. Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions. Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3. Interacts with NRIP1. Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts with CLOCK and the interaction is stimulated by…
messages: Cell membrane
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).
messages: Cytoplasm
messages: Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-260.
messages: Golgi apparatus
messages: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades.Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
messages: Nucleus
messages: Palmitoylated at Cys-447 by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor (By similarity).
messages: Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity (By similarity). Phosphorylated by LMTK3 (in vitro) (By similarity).
messages: Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1.

9796:SELE
gene id: 9796:SELE
uniprot id: F6QAA7
uniprot id: Q95LG1
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Cell-surface glycoprotein having a role in immunoadhesion (PubMed:11529941). Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis (By similarity).
messages: Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Up-regulated in endothelial cells after exposure to bacterial lipopolysaccharide (LPS).

9796:VEPH1
gene id: 9796:VEPH1
uniprot id: F6SN43
names: Similarity
messages: Belongs to the MELT/VEPH family.

9796:CCKBR
gene id: 9796:CCKBR
uniprot id: F6S229
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:TXK
gene id: 9796:TXK
uniprot id: F6Y4C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9796:B4GALT3
gene id: 9796:B4GALT3
uniprot id: F6YFG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9796:FOLH1B
gene id: 9796:FOLH1B
uniprot id: F6TC16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9796:PPP1R14D
gene id: 9796:PPP1R14D
uniprot id: F7DGQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9796:SLC5A11
gene id: 9796:SLC5A11
uniprot id: F7CTM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9796:LOC100066712
gene id: 9796:LOC100066712
uniprot id: F7E3L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TINAGL1
gene id: 9796:TINAGL1
uniprot id: F7CC59
names: Similarity
messages: Belongs to the peptidase C1 family.

9796:LOC100065543
gene id: 9796:LOC100065543
uniprot id: F6Z3A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9796:HIGD1A
gene id: 9796:HIGD1A
uniprot id: F7D0A9
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9796:GSX2
gene id: 9796:GSX2
uniprot id: F7BJ43
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100068228
gene id: 9796:LOC100068228
uniprot id: A0A3Q2HF90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RETNLB
gene id: 9796:RETNLB
uniprot id: A0A3Q2KWM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9796:FST
gene id: 9796:FST
uniprot id: O62650
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
messages: Monomer.
messages: Secreted

9796:SH3BGRL
gene id: 9796:SH3BGRL
uniprot id: F6RMM1
names: Similarity
messages: Belongs to the SH3BGR family.

9796:S100A1
gene id: 9796:S100A1
uniprot id: F6UNB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Mitochondrion

9796:NNAT
gene id: 9796:NNAT
uniprot id: A0A3Q2LHL2
names: Similarity
messages: Belongs to the neuronatin family.

9796:LOC100053695
gene id: 9796:LOC100053695
uniprot id: A0A3Q2HBF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:GLRX
gene id: 9796:GLRX
uniprot id: F6QR81
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9796:PDCD4
gene id: 9796:PDCD4
uniprot id: A0A3Q2I7F1
names: Similarity
messages: Belongs to the PDCD4 family.

9796:SPO11
gene id: 9796:SPO11
uniprot id: F6PUB2
names: Similarity
messages: Belongs to the TOP6A family.

9796:PFN3
gene id: 9796:PFN3
uniprot id: F6SLI0
names: Similarity
messages: Belongs to the profilin family.

9796:UBC
gene id: 9796:UBC
uniprot id: Q8MKD1
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
messages: For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
messages: Interacts with SKP1-KMD2A and SKP1-KMD2B complexes.
messages: Mitochondrion outer membrane
messages: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.
messages: Nucleus
messages: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.
messages: Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

9796:BICD1
gene id: 9796:BICD1
uniprot id: A0A3Q2I6W2
uniprot id: A0A3Q2LER7
names: Similarity
messages: Belongs to the BicD family.

9796:CXCL12
gene id: 9796:CXCL12
uniprot id: A0A5F5Q038
uniprot id: F7DYQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9796:CDH18
gene id: 9796:CDH18
uniprot id: F7BLF0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9796:GART
gene id: 9796:GART
uniprot id: F6UW37
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

9796:IL1RN
gene id: 9796:IL1RN
uniprot id: A0A3Q2HJN8
uniprot id: O18999
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9796:CDC42EP3
gene id: 9796:CDC42EP3
uniprot id: F6VU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9796:AREG
gene id: 9796:AREG
uniprot id: F7AX73
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:HAPLN1
gene id: 9796:HAPLN1
uniprot id: Q28381
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAPLN family.
messages: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
messages: extracellular matrix

9796:PIK3CD
gene id: 9796:PIK3CD
uniprot id: F7DHK6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9796:FAM133B
gene id: 9796:FAM133B
uniprot id: F6ZQ17
names: Similarity
messages: Belongs to the FAM133 family.

9796:LAMTOR2
gene id: 9796:LAMTOR2
uniprot id: F6Z4M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9796:KHDC4
gene id: 9796:KHDC4
uniprot id: F6ZX16
names: Similarity
messages: Belongs to the KHDC4 family.

9796:LOC100072019
gene id: 9796:LOC100072019
uniprot id: A0A3Q2LBH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PSMA5
gene id: 9796:PSMA5
uniprot id: F6VEA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9796:ST6GALNAC1
gene id: 9796:ST6GALNAC1
uniprot id: F6S9S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9796:SLC30A8
gene id: 9796:SLC30A8
uniprot id: F6S343
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cell membrane
messages: Membrane
messages: secretory vesicle membrane

9796:SPDYA
gene id: 9796:SPDYA
uniprot id: A0A3Q2H221
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9796:RPL36A
gene id: 9796:RPL36A
uniprot id: F6TTX8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9796:LOC102148936
gene id: 9796:LOC102148936
uniprot id: A0A3Q2HJ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9796:CKAP2
gene id: 9796:CKAP2
uniprot id: F6PVP2
names: Similarity
messages: Belongs to the CKAP2 family.

9796:MYOD1
gene id: 9796:MYOD1
uniprot id: F6W511
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9796:ITGA2B
gene id: 9796:ITGA2B
uniprot id: Q7YRP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9796:CYP3A89
gene id: 9796:CYP3A89
uniprot id: A7LGW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:GHITM
gene id: 9796:GHITM
uniprot id: K9K4F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9796:FBXO32
gene id: 9796:FBXO32
uniprot id: F6V026
names: Subcellular Location Annotation
messages: Nucleus

9796:NDUFAF3
gene id: 9796:NDUFAF3
uniprot id: F6Z8H7
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9796:A4GNT
gene id: 9796:A4GNT
uniprot id: A0A3Q2HMU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9796:GNG8
gene id: 9796:GNG8
uniprot id: F6R7Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9796:ITGA1
gene id: 9796:ITGA1
uniprot id: A0A3Q2HMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9796:KPNA6
gene id: 9796:KPNA6
uniprot id: F6ZAL1
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9796:SLC4A11
gene id: 9796:SLC4A11
uniprot id: A0A3Q2GVN2
uniprot id: A0A3Q2HLA8
uniprot id: A0A3Q2HQD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9796:CASC1
gene id: 9796:CASC1
uniprot id: F6W570
names: Similarity
messages: Belongs to the DNAI7 family.

9796:RPS6KA1
gene id: 9796:RPS6KA1
uniprot id: A0A3Q2GTT1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9796:ATP6V1E1
gene id: 9796:ATP6V1E1
uniprot id: F6WUU4
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9796:ZDHHC14
gene id: 9796:ZDHHC14
uniprot id: F7CUK4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9796:LGB1
gene id: 9796:LGB1
uniprot id: P02758
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
messages: Monomer.
messages: Secreted

9796:FOLR1
gene id: 9796:FOLR1
uniprot id: F7DI80
names: Similarity
messages: Belongs to the folate receptor family.

9796:AMH
gene id: 9796:AMH
uniprot id: F2YMM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
messages: Secreted

9796:ARL5B
gene id: 9796:ARL5B
uniprot id: F6WTX4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9796:INTS14
gene id: 9796:INTS14
uniprot id: A0A3Q2I539
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9796:SLC30A7
gene id: 9796:SLC30A7
uniprot id: F6ZXQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9796:SEMA3F
gene id: 9796:SEMA3F
uniprot id: A0A3Q2IK27
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:TXN
gene id: 9796:TXN
uniprot id: O97508
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioredoxin family.
messages: Cytoplasm
messages: Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (By similarity).
messages: In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity).
messages: Nucleus
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
messages: Secreted

9796:APH1A
gene id: 9796:APH1A
uniprot id: A0A3Q2LD75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9796:GPCPD1
gene id: 9796:GPCPD1
uniprot id: A0A3Q2ICJ7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9796:ATF2
gene id: 9796:ATF2
uniprot id: F7B0R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a dimer and can form a homodimer in the absence of DNA.
messages: Nucleus
messages: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3').

9796:PGM2
gene id: 9796:PGM2
uniprot id: A0A3Q2GWI8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9796:SH3BP5L
gene id: 9796:SH3BP5L
uniprot id: F7DWH3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9796:TMEM150B
gene id: 9796:TMEM150B
uniprot id: F6PV05
names: Subcellular Location Annotation
messages: Membrane

9796:XIRP2
gene id: 9796:XIRP2
uniprot id: F6WVL9
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9796:EDN1
gene id: 9796:EDN1
uniprot id: F7APB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9796:MSN
gene id: 9796:MSN
uniprot id: F6PUX2
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9796:LOC100067992
gene id: 9796:LOC100067992
uniprot id: F6V5Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:IL1R1
gene id: 9796:IL1R1
uniprot id: Q9TV71
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9796:MLH3
gene id: 9796:MLH3
uniprot id: A0A3Q2HLQ9
uniprot id: A0A5F5PJD7
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9796:PPP1R9A
gene id: 9796:PPP1R9A
uniprot id: A0A3Q2LJI1
names: Subcellular Location Annotation
messages: cytoskeleton

9796:AMER1
gene id: 9796:AMER1
uniprot id: F6WVP3
names: Similarity
messages: Belongs to the Amer family.

9796:GMPPA
gene id: 9796:GMPPA
uniprot id: F7BEM5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9796:LOC100058280
gene id: 9796:LOC100058280
uniprot id: A0A5F5PEK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:COL4A5
gene id: 9796:COL4A5
uniprot id: A0A5F5PXR6
uniprot id: F7C5C2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9796:ACSF2
gene id: 9796:ACSF2
uniprot id: F7DYP0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9796:CELF1
gene id: 9796:CELF1
uniprot id: A0A3Q2GSP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9796:LOC100146423
gene id: 9796:LOC100146423
uniprot id: M1ZMN7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9796:POMT1
gene id: 9796:POMT1
uniprot id: F6RXK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9796:INHBA
gene id: 9796:INHBA
uniprot id: P55102
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9796:LOC100051420
gene id: 9796:LOC100051420
uniprot id: F7AED2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9796:LOC106782093
gene id: 9796:LOC106782093
uniprot id: F7DFF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GINS3
gene id: 9796:GINS3
uniprot id: F6YPP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9796:LOC100057758
gene id: 9796:LOC100057758
uniprot id: F6S4T4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9796:MED28
gene id: 9796:MED28
uniprot id: F6PSC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9796:LOC100056428
gene id: 9796:LOC100056428
uniprot id: F7C973
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9796:PRICKLE1
gene id: 9796:PRICKLE1
uniprot id: F6Z985
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9796:GREM2
gene id: 9796:GREM2
uniprot id: F6XPS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:NQO2
gene id: 9796:NQO2
uniprot id: F6W2T9
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9796:NOL12
gene id: 9796:NOL12
uniprot id: A0A3Q2L071
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

9796:KEF40 p08
gene id: 9796:KEF40_p08
uniprot id: P48662
uniprot id: Q6J6X0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9796:NRF1
gene id: 9796:NRF1
uniprot id: F6RH17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9796:PITX2
gene id: 9796:PITX2
uniprot id: A0A3Q2I2X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9796:NOS2
gene id: 9796:NOS2
uniprot id: Q9BDH6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

9796:DHDH
gene id: 9796:DHDH
uniprot id: F7C081
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9796:PAPPA2
gene id: 9796:PAPPA2
uniprot id: F6R5T7
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:RNMT
gene id: 9796:RNMT
uniprot id: F7BPA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9796:SLC26A1
gene id: 9796:SLC26A1
uniprot id: F6XKP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate.
messages: Membrane

9796:LOC100065612
gene id: 9796:LOC100065612
uniprot id: F7BH81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9796:CYB5A
gene id: 9796:CYB5A
uniprot id: F6S4S4
names: Similarity
messages: Belongs to the cytochrome b5 family.

9796:ST8SIA4
gene id: 9796:ST8SIA4
uniprot id: F7AEM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9796:SLC27A2
gene id: 9796:SLC27A2
uniprot id: F6WIN6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9796:APOC4
gene id: 9796:APOC4
uniprot id: A0A5F5PQA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

9796:LDB2
gene id: 9796:LDB2
uniprot id: A0A3Q2HQK2
names: Similarity
messages: Belongs to the LDB family.

9796:TUBA4A
gene id: 9796:TUBA4A
uniprot id: F7DNT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9796:CPLX4
gene id: 9796:CPLX4
uniprot id: F6WCE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9796:SLC27A6
gene id: 9796:SLC27A6
uniprot id: F7CKE7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9796:POLD3
gene id: 9796:POLD3
uniprot id: A6P7L4
uniprot id: F6SLX9
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100065549
gene id: 9796:LOC100065549
uniprot id: F7D230
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FUT7
gene id: 9796:FUT7
uniprot id: F6YH91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9796:LOC102148861
gene id: 9796:LOC102148861
uniprot id: F7AYX4
names: Similarity
messages: Belongs to the profilin family.

9796:IFRD1
gene id: 9796:IFRD1
uniprot id: F6S173
names: Similarity
messages: Belongs to the IFRD family.

9796:PCYOX1L
gene id: 9796:PCYOX1L
uniprot id: F7CS80
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9796:COPS3
gene id: 9796:COPS3
uniprot id: F6U5X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN3 family.
messages: Cytoplasm
messages: Nucleus

9796:ALDH1A2
gene id: 9796:ALDH1A2
uniprot id: F7CVL4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9796:B4GALNT2
gene id: 9796:B4GALNT2
uniprot id: A0A3Q2ICK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

9796:THRAP3
gene id: 9796:THRAP3
uniprot id: F6U4J8
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9796:LZIC
gene id: 9796:LZIC
uniprot id: F6YZT7
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9796:EXOC7
gene id: 9796:EXOC7
uniprot id: A0A3Q2HSZ2
uniprot id: A0A3Q2I8T4
uniprot id: A0A3Q2KWF7
uniprot id: A0A3Q2L9N3
uniprot id: F7D1R8
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9796:CASP2
gene id: 9796:CASP2
uniprot id: A0A3Q2H985
uniprot id: A0A3Q2HA07
names: Similarity
messages: Belongs to the peptidase C14A family.

9796:USP39
gene id: 9796:USP39
uniprot id: F6WVK2
names: Subcellular Location Annotation
messages: Nucleus

9796:PICALM
gene id: 9796:PICALM
uniprot id: A0A3Q2IB34
uniprot id: F7D8Z8
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9796:PRL
gene id: 9796:PRL
uniprot id: A0A0M6L0Z4
uniprot id: P12420
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the somatotropin/prolactin family.
messages: Interacts with PRLR.
messages: Prolactin acts primarily on the mammary gland by promoting lactation.
messages: Secreted

9796:CLEC16A
gene id: 9796:CLEC16A
uniprot id: F6TYT8
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9796:TRAPPC3
gene id: 9796:TRAPPC3
uniprot id: F6SIS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9796:HPSE
gene id: 9796:HPSE
uniprot id: F7BXT6
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9796:GGH
gene id: 9796:GGH
uniprot id: F7CAQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9796:ATP13A1
gene id: 9796:ATP13A1
uniprot id: F6VB73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9796:ACYP2
gene id: 9796:ACYP2
uniprot id: A0A3Q2HXC0
names: Similarity
messages: Belongs to the acylphosphatase family.

9796:TNFSF10
gene id: 9796:TNFSF10
uniprot id: A0A060GP82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9796:CRB1
gene id: 9796:CRB1
uniprot id: A0A3Q2H002
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:RETN
gene id: 9796:RETN
uniprot id: F6W1S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9796:STEAP4
gene id: 9796:STEAP4
uniprot id: A0A3Q2KVD8
uniprot id: F7A3D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9796:LOC100065342
gene id: 9796:LOC100065342
uniprot id: A0A3Q2GWU4
uniprot id: A0A5F5PGH0
uniprot id: F6Z505
uniprot id: F6Z5R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9796:SPI2
gene id: 9796:SPI2
uniprot id: B5BV00
uniprot id: P38029
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Inhibitor of serine proteases.
messages: N-glycosylated with carbohydrates having biantennary side chains.
messages: Plasma.
messages: Secreted
messages: The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the active site of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).

9796:CCNO
gene id: 9796:CCNO
uniprot id: F6UDG1
names: Similarity
messages: Belongs to the cyclin family.

9796:KLHL22
gene id: 9796:KLHL22
uniprot id: F6UYJ8
names: Subcellular Location Annotation
messages: Lysosome
messages: Nucleus
messages: centrosome
messages: cytosol
messages: spindle

9796:PGM1
gene id: 9796:PGM1
uniprot id: A0A5F5PI91
uniprot id: F6X8Q2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9796:LOC100060690
gene id: 9796:LOC100060690
uniprot id: F6X3A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PKLR
gene id: 9796:PKLR
uniprot id: F7ANK4
names: Similarity
messages: Belongs to the pyruvate kinase family.

9796:CCL11
gene id: 9796:CCL11
uniprot id: Q9TTQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils (By similarity). Binds to CCR3 (By similarity).
messages: Secreted

9796:STAM
gene id: 9796:STAM
uniprot id: F7DIA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9796:FARS2
gene id: 9796:FARS2
uniprot id: F7C7S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

9796:TRPV5
gene id: 9796:TRPV5
uniprot id: A0A5F5PWY0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:RAB3GAP2
gene id: 9796:RAB3GAP2
uniprot id: F7DAH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

9796:LOC100070314
gene id: 9796:LOC100070314
uniprot id: F6Y8M4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CDC42BPA
gene id: 9796:CDC42BPA
uniprot id: A0A3Q2GZX8
uniprot id: A0A3Q2HYF2
uniprot id: A0A3Q2KRM9
uniprot id: A0A3Q2LBI2
uniprot id: A0A5F5PG40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9796:BEST3
gene id: 9796:BEST3
uniprot id: F6TI80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9796:LOC100071565
gene id: 9796:LOC100071565
uniprot id: A0A3Q2I425
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:IFNK
gene id: 9796:IFNK
uniprot id: F6XJ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:C5H1orf74
gene id: 9796:C5H1orf74
uniprot id: F6X708
names: Similarity
messages: Belongs to the UPF0739 family.

9796:TNFSF13B
gene id: 9796:TNFSF13B
uniprot id: F2VR36
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9796:KRT34
gene id: 9796:KRT34
uniprot id: F6YSL6
names: Similarity
messages: Belongs to the intermediate filament family.

9796:SFR1
gene id: 9796:SFR1
uniprot id: F6SSL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9796:GANAB
gene id: 9796:GANAB
uniprot id: A0A3Q2HNI5
uniprot id: F7C4H8
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9796:GBA
gene id: 9796:GBA
uniprot id: F6WDY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Lysosome membrane

9796:SMAD5
gene id: 9796:SMAD5
uniprot id: F7A120
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9796:LOC100072117
gene id: 9796:LOC100072117
uniprot id: F7A855
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PCNX3
gene id: 9796:PCNX3
uniprot id: F7A1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9796:ATP5PB
gene id: 9796:ATP5PB
uniprot id: A0A3Q2ICH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9796:LOC102149062
gene id: 9796:LOC102149062
uniprot id: F7C9U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9796:PARP2
gene id: 9796:PARP2
uniprot id: A0A3Q2HR55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9796:LSM1
gene id: 9796:LSM1
uniprot id: F6Q4X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9796:LOC100063146
gene id: 9796:LOC100063146
uniprot id: A0A3Q2H1G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9796:TMEM230
gene id: 9796:TMEM230
uniprot id: F6PLK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9796:LOC100061154
gene id: 9796:LOC100061154
uniprot id: A0A3Q2HQ75
names: Function
names: Similarity
messages: Belongs to the MS4A family.
messages: May be involved in signal transduction as a component of a multimeric receptor complex.

9796:AMOT
gene id: 9796:AMOT
uniprot id: F6TAL1
names: Similarity
messages: Belongs to the angiomotin family.

9796:LOC100070570
gene id: 9796:LOC100070570
uniprot id: A0A3Q2GTH2
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9796:LOC100052276
gene id: 9796:LOC100052276
uniprot id: F6RI16
names: Subcellular Location Annotation
messages: Nucleus

9796:NLGN1
gene id: 9796:NLGN1
uniprot id: A0A5F5PER0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9796:LOC100072639
gene id: 9796:LOC100072639
uniprot id: A0A3Q2H044
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9796:LOC100068606
gene id: 9796:LOC100068606
uniprot id: F6V4F6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9796:HSDL2
gene id: 9796:HSDL2
uniprot id: F6PQF9
names: Subcellular Location Annotation
messages: Peroxisome

9796:STEAP1
gene id: 9796:STEAP1
uniprot id: F6TQN7
names: Subcellular Location Annotation
messages: Membrane

9796:TFAP2B
gene id: 9796:TFAP2B
uniprot id: A0A5F5Q2L0
uniprot id: F6VFE2
names: Similarity
messages: Belongs to the AP-2 family.

9796:CALCR
gene id: 9796:CALCR
uniprot id: F6YHG4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

9796:GDNF
gene id: 9796:GDNF
uniprot id: A0A3Q2LC49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9796:LOC100068123
gene id: 9796:LOC100068123
uniprot id: A0A3Q2HZC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:IFN-OMEGA1
gene id: 9796:IFN-OMEGA1
uniprot id: P05001
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:MCM2
gene id: 9796:MCM2
uniprot id: F7DDB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9796:CUZD1
gene id: 9796:CUZD1
uniprot id: F7D2L3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:CER1
gene id: 9796:CER1
uniprot id: F7DS65
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:SYS1
gene id: 9796:SYS1
uniprot id: F6U493
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9796:CREBL2
gene id: 9796:CREBL2
uniprot id: A0A5F5PFE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9796:RP2
gene id: 9796:RP2
uniprot id: F6RL28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9796:LOC100055645
gene id: 9796:LOC100055645
uniprot id: A0A3Q2LSD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100066541
gene id: 9796:LOC100066541
uniprot id: F6PK34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TSC22D1
gene id: 9796:TSC22D1
uniprot id: A0A3Q2HCK7
uniprot id: A0A3Q2I7D9
uniprot id: A0A5F5PWK9
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9796:PRKCH
gene id: 9796:PRKCH
uniprot id: F7BA26
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9796:LOC100050266
gene id: 9796:LOC100050266
uniprot id: A0A3Q2LBK1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:NMUR2
gene id: 9796:NMUR2
uniprot id: F7DC92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9796:HMGCS2
gene id: 9796:HMGCS2
uniprot id: F7CBP9
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9796:LOC100629761
gene id: 9796:LOC100629761
uniprot id: A0A3Q2LE54
names: Similarity
messages: Belongs to the KRTAP type 3 family.

9796:SUMF1
gene id: 9796:SUMF1
uniprot id: A0A5F5PLM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9796:DGAT2L6
gene id: 9796:DGAT2L6
uniprot id: F7B020
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:IRF7
gene id: 9796:IRF7
uniprot id: F6YQ51
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9796:OPN1LW
gene id: 9796:OPN1LW
uniprot id: O18912
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: The three color pigments are found in the cone photoreceptor cells. Expressed in retina (PubMed:10511567).
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

9796:LOC100063279
gene id: 9796:LOC100063279
uniprot id: F6W5M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CAPN13
gene id: 9796:CAPN13
uniprot id: F6YBE6
names: Similarity
messages: Belongs to the peptidase C2 family.

9796:LOC100059997
gene id: 9796:LOC100059997
uniprot id: A0A3Q2H821
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9796:STOML2
gene id: 9796:STOML2
uniprot id: F6R2L2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9796:ASIC3
gene id: 9796:ASIC3
uniprot id: E1A463
names: Subcellular Location Annotation
messages: Membrane

9796:SEC24C
gene id: 9796:SEC24C
uniprot id: A0A3Q2GZ08
uniprot id: F6XTW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9796:RAB9A
gene id: 9796:RAB9A
uniprot id: F6QIK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9796:LOC100071766
gene id: 9796:LOC100071766
uniprot id: F7A928
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TRIM10
gene id: 9796:TRIM10
uniprot id: F6XN17
names: Similarity
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2.

9796:LOC100060483
gene id: 9796:LOC100060483
uniprot id: F6QGE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.

9796:LOC100146955
gene id: 9796:LOC100146955
uniprot id: F7BYJ1
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9796:CUL2
gene id: 9796:CUL2
uniprot id: A0A3Q2L9D5
names: Similarity
messages: Belongs to the cullin family.

9796:SLC4A1
gene id: 9796:SLC4A1
uniprot id: Q2Z1P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9796:RASGRP3
gene id: 9796:RASGRP3
uniprot id: F6QDS7
names: Similarity
messages: Belongs to the RASGRP family.

9796:ADGRB3
gene id: 9796:ADGRB3
uniprot id: A0A3Q2H5C7
names: Subcellular Location Annotation
messages: Membrane

9796:CUTA
gene id: 9796:CUTA
uniprot id: F6TVZ7
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9796:THPO
gene id: 9796:THPO
uniprot id: F7BPK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9796:LOC100061342
gene id: 9796:LOC100061342
uniprot id: F6XXM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LIAS
gene id: 9796:LIAS
uniprot id: F6TSL6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9796:TACC1
gene id: 9796:TACC1
uniprot id: F7DMN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9796:LOC100054762
gene id: 9796:LOC100054762
uniprot id: F6QK06
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ORC2
gene id: 9796:ORC2
uniprot id: F6WIM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9796:CYB5RL
gene id: 9796:CYB5RL
uniprot id: A0A3Q2I724
uniprot id: A0A5F5PPS7
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9796:ORC5
gene id: 9796:ORC5
uniprot id: A0A3Q2IA91
uniprot id: A0A3Q2LSU9
uniprot id: F6V340
names: Subcellular Location Annotation
messages: Nucleus

9796:LHX4
gene id: 9796:LHX4
uniprot id: F7C7F3
names: Subcellular Location Annotation
messages: Nucleus

9796:MTRF1L
gene id: 9796:MTRF1L
uniprot id: F6WJR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9796:ENTPD5
gene id: 9796:ENTPD5
uniprot id: A0A3Q2I7T6
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9796:CCR2
gene id: 9796:CCR2
uniprot id: B3SPX1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:HSD17B1
gene id: 9796:HSD17B1
uniprot id: A3QRK1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:ATP6V1D
gene id: 9796:ATP6V1D
uniprot id: F6SBI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9796:NCAPD2
gene id: 9796:NCAPD2
uniprot id: F7CU59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

9796:DPH1
gene id: 9796:DPH1
uniprot id: F6YVY5
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.

9796:ST7L
gene id: 9796:ST7L
uniprot id: A0A3Q2LNG2
uniprot id: A0A5F5PK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9796:CPA5
gene id: 9796:CPA5
uniprot id: F7E0P9
names: Similarity
messages: Belongs to the peptidase M14 family.

9796:KAT5
gene id: 9796:KAT5
uniprot id: A0A3Q2I554
uniprot id: A0A3Q2KTV4
uniprot id: F6UXD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9796:LOC100069376
gene id: 9796:LOC100069376
uniprot id: F6WV11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ZNF287
gene id: 9796:ZNF287
uniprot id: F6Z3M1
names: Subcellular Location Annotation
messages: Nucleus

9796:FLI1
gene id: 9796:FLI1
uniprot id: F6WG81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:ARMCX3
gene id: 9796:ARMCX3
uniprot id: F6TMP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9796:PLPPR2
gene id: 9796:PLPPR2
uniprot id: F6PH20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9796:LGMN
gene id: 9796:LGMN
uniprot id: F6QSX9
names: Similarity
messages: Belongs to the peptidase C13 family.

9796:LOC100072071
gene id: 9796:LOC100072071
uniprot id: A0A3Q2HY78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DNAJC27
gene id: 9796:DNAJC27
uniprot id: F6QPG4
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9796:TMBIM1
gene id: 9796:TMBIM1
uniprot id: F6TF18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9796:LOC106781464
gene id: 9796:LOC106781464
uniprot id: A0A5F5PWY7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:IGFBP1
gene id: 9796:IGFBP1
uniprot id: F7DMX6
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:SHCBP1L
gene id: 9796:SHCBP1L
uniprot id: F6SKW3
names: Subcellular Location Annotation
messages: spindle

9796:CHRNA1
gene id: 9796:CHRNA1
uniprot id: F7E1H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:CLTC
gene id: 9796:CLTC
uniprot id: A0A3Q2GYQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9796:LAMTOR3
gene id: 9796:LAMTOR3
uniprot id: F6ZMH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9796:CLIC5
gene id: 9796:CLIC5
uniprot id: A0A3Q2I8W6
uniprot id: A0A5F5PJ72
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9796:LOC100057021
gene id: 9796:LOC100057021
uniprot id: F7CSG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ZC3HAV1
gene id: 9796:ZC3HAV1
uniprot id: A0A3Q2H0Z6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9796:RGS1
gene id: 9796:RGS1
uniprot id: K9KEW5
uniprot id: Q6RG78
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with GNAI1 and GNAQ.
messages: Membrane
messages: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity).
messages: cytosol

9796:CLDN12
gene id: 9796:CLDN12
uniprot id: F7B304
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9796:BCS1L
gene id: 9796:BCS1L
uniprot id: F7CCP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9796:PSKH1
gene id: 9796:PSKH1
uniprot id: F6X9W0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:BPNT1
gene id: 9796:BPNT1
uniprot id: A0A3Q2HBV4
uniprot id: F6UIC2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9796:TRAPPC13
gene id: 9796:TRAPPC13
uniprot id: A0A3Q2LMT0
uniprot id: F6QR15
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9796:LOC100146503
gene id: 9796:LOC100146503
uniprot id: F7BSE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100052921
gene id: 9796:LOC100052921
uniprot id: P05006
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
messages: Secreted

9796:LOC100053424
gene id: 9796:LOC100053424
uniprot id: F6Z592
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9796:ADAM9
gene id: 9796:ADAM9
uniprot id: F7D9Z8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:CHRND
gene id: 9796:CHRND
uniprot id: F6VC36
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:ERAP1
gene id: 9796:ERAP1
uniprot id: F7BLK5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9796:GSDMD
gene id: 9796:GSDMD
uniprot id: F7CWF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9796:MRPL49
gene id: 9796:MRPL49
uniprot id: F6YVM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

9796:FAM53C
gene id: 9796:FAM53C
uniprot id: F6VCW1
names: Similarity
messages: Belongs to the FAM53 family.

9796:URM1
gene id: 9796:URM1
uniprot id: A0A5F5PVE5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9796:COMT
gene id: 9796:COMT
uniprot id: Q5H879
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
messages: Cell membrane
messages: Cytoplasm

9796:TCTA
gene id: 9796:TCTA
uniprot id: F7AIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9796:SKAP2
gene id: 9796:SKAP2
uniprot id: F7DBH3
names: Similarity
messages: Belongs to the SKAP family.

9796:PRKCQ
gene id: 9796:PRKCQ
uniprot id: F6WA17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9796:ANXA3
gene id: 9796:ANXA3
uniprot id: F6ZAK1
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9796:B3GALT1
gene id: 9796:B3GALT1
uniprot id: F6TWA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:GRAP2
gene id: 9796:GRAP2
uniprot id: F7E1F5
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9796:RETREG3
gene id: 9796:RETREG3
uniprot id: F6UMD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9796:POLR1E
gene id: 9796:POLR1E
uniprot id: F7DSI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9796:PHTF1
gene id: 9796:PHTF1
uniprot id: F6S517
names: Subcellular Location Annotation
messages: Membrane

9796:CDC45
gene id: 9796:CDC45
uniprot id: H9GZX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9796:SQLE
gene id: 9796:SQLE
uniprot id: F6ZRA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9796:SNX32
gene id: 9796:SNX32
uniprot id: A0A3Q2IAI2
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9796:HCN3
gene id: 9796:HCN3
uniprot id: F7D898
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9796:MRPL32
gene id: 9796:MRPL32
uniprot id: F6Y3H3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9796:STK40
gene id: 9796:STK40
uniprot id: F6VRI4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9796:SLC52A2
gene id: 9796:SLC52A2
uniprot id: F6UD01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9796:BMP15
gene id: 9796:BMP15
uniprot id: F6V249
names: Similarity
messages: Belongs to the TGF-beta family.

9796:LOC100053601
gene id: 9796:LOC100053601
uniprot id: A0A3Q2HX90
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9796:CCDC47
gene id: 9796:CCDC47
uniprot id: F7CNB5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Rough endoplasmic reticulum membrane

9796:FAH
gene id: 9796:FAH
uniprot id: F6U354
names: Similarity
messages: Belongs to the FAH family.

9796:GDF5
gene id: 9796:GDF5
uniprot id: F7BKJ7
names: Similarity
messages: Belongs to the TGF-beta family.

9796:FUNDC2
gene id: 9796:FUNDC2
uniprot id: F6RA93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9796:IGFBP5
gene id: 9796:IGFBP5
uniprot id: F7ALY5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:LOC100051428
gene id: 9796:LOC100051428
uniprot id: F6W9S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ATP5MG
gene id: 9796:ATP5MG
uniprot id: F7BYD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9796:GPT2
gene id: 9796:GPT2
uniprot id: F6YQI3
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9796:SAA
gene id: 9796:SAA
uniprot id: Q9N0Y1
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9796:PGAP2
gene id: 9796:PGAP2
uniprot id: A0A3Q2HNJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9796:LOC100630350
gene id: 9796:LOC100630350
uniprot id: F6SFN4
names: Similarity
messages: Belongs to the TMEM14 family.

9796:RRAGA
gene id: 9796:RRAGA
uniprot id: A0A3Q2H8X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9796:C15H2orf68
gene id: 9796:C15H2orf68
uniprot id: F7DN55
names: Similarity
messages: Belongs to the UPF0561 family.

9796:CALCB
gene id: 9796:CALCB
uniprot id: Q9N0T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (By similarity).
messages: Secreted

9796:PSMD5
gene id: 9796:PSMD5
uniprot id: F7BBH3
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9796:GPR171
gene id: 9796:GPR171
uniprot id: F6VN40
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:RPL18
gene id: 9796:RPL18
uniprot id: F6YJR6
uniprot id: Q0QEV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Rough endoplasmic reticulum

9796:PLXNA4
gene id: 9796:PLXNA4
uniprot id: F6R9W9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:LOC100062768
gene id: 9796:LOC100062768
uniprot id: F7ADT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:SPOP
gene id: 9796:SPOP
uniprot id: F7A1J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9796:TATDN1
gene id: 9796:TATDN1
uniprot id: L7MRM1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9796:LOC100067128
gene id: 9796:LOC100067128
uniprot id: F7C517
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MEIG1
gene id: 9796:MEIG1
uniprot id: A0A3Q2LTT9
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9796:PRAME
gene id: 9796:PRAME
uniprot id: A0A3Q2IGS7
names: Similarity
messages: Belongs to the PRAME family.

9796:LOC100056283
gene id: 9796:LOC100056283
uniprot id: F6TCR6
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9796:DCTD
gene id: 9796:DCTD
uniprot id: F6RWS3
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9796:NCF2
gene id: 9796:NCF2
uniprot id: F6T8Y6
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9796:YARS2
gene id: 9796:YARS2
uniprot id: F6ZTM2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9796:LOC100058884
gene id: 9796:LOC100058884
uniprot id: A0A5F5PIT3
uniprot id: F7AKZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9796:STAT6
gene id: 9796:STAT6
uniprot id: F6WTW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9796:LOC102149981
gene id: 9796:LOC102149981
uniprot id: F6T3P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TCAF1
gene id: 9796:TCAF1
uniprot id: A0A5F5PQS6
names: Similarity
messages: Belongs to the TCAF family.

9796:GCN1
gene id: 9796:GCN1
uniprot id: F6R2I7
names: Similarity
messages: Belongs to the GCN1 family.

9796:LIG3
gene id: 9796:LIG3
uniprot id: A0A3Q2IKK5
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

9796:TRIP10
gene id: 9796:TRIP10
uniprot id: A0A3Q2HU88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Lysosome
messages: Membrane
messages: cell cortex

9796:LOC100057251
gene id: 9796:LOC100057251
uniprot id: A0A5F5Q2Q9
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9796:MRPS23
gene id: 9796:MRPS23
uniprot id: F6QPW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

9796:NUDT17
gene id: 9796:NUDT17
uniprot id: F6U597
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

9796:MFSD6
gene id: 9796:MFSD6
uniprot id: F6RZH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9796:DSCR3
gene id: 9796:DSCR3
uniprot id: F7CJJ6
names: Similarity
messages: Belongs to the VPS26 family.

9796:C7H19orf53
gene id: 9796:C7H19orf53
uniprot id: F6SUF8
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9796:SIDT2
gene id: 9796:SIDT2
uniprot id: A0A3Q2HJX8
uniprot id: F6Y6L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9796:CPNE4
gene id: 9796:CPNE4
uniprot id: A0A3Q2GX48
names: Similarity
messages: Belongs to the copine family.

9796:EMC6
gene id: 9796:EMC6
uniprot id: F6QQ51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:BAAT
gene id: 9796:BAAT
uniprot id: F6Q5W5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9796:LOC100071373
gene id: 9796:LOC100071373
uniprot id: F6TEU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

9796:LOC100056271
gene id: 9796:LOC100056271
uniprot id: F6XY61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ABCC1
gene id: 9796:ABCC1
uniprot id: Q0NXS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9796:ABRAXAS2
gene id: 9796:ABRAXAS2
uniprot id: A0A3Q2H0Z7
names: Subcellular Location Annotation
messages: Nucleus

9796:POP5
gene id: 9796:POP5
uniprot id: F7B3D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9796:HBZ
gene id: 9796:HBZ
uniprot id: P13787
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two zeta chains and beta-type chains.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

9796:NCK2
gene id: 9796:NCK2
uniprot id: A0A3Q2H3S9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9796:RBPJ
gene id: 9796:RBPJ
uniprot id: F7E3E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9796:LOC100050329
gene id: 9796:LOC100050329
uniprot id: F6VIF4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:C21H5orf22
gene id: 9796:C21H5orf22
uniprot id: F6ZX30
names: Similarity
messages: Belongs to the UPF0489 family.

9796:LAMTOR5
gene id: 9796:LAMTOR5
uniprot id: F6Y761
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

9796:ZNF165
gene id: 9796:ZNF165
uniprot id: F6ZJD1
names: Subcellular Location Annotation
messages: Nucleus

9796:GSPT2
gene id: 9796:GSPT2
uniprot id: A0A5F5Q1J0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9796:KCNK17
gene id: 9796:KCNK17
uniprot id: F6QYK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9796:PSME3
gene id: 9796:PSME3
uniprot id: A0A3Q2H5V3
uniprot id: F6QVK5
names: Similarity
messages: Belongs to the PA28 family.

9796:DNAJB12
gene id: 9796:DNAJB12
uniprot id: F6PMT4
names: Subcellular Location Annotation
messages: Membrane

9796:SLC2A4
gene id: 9796:SLC2A4
uniprot id: Q8MJ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9796:SLC25A29
gene id: 9796:SLC25A29
uniprot id: F6ZES9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:MRAP
gene id: 9796:MRAP
uniprot id: A0A5F5PZ89
uniprot id: F6SGP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:MAGI3
gene id: 9796:MAGI3
uniprot id: A0A3Q2GVZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9796:HOXA7
gene id: 9796:HOXA7
uniprot id: F7ASR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9796:LOC106781434
gene id: 9796:LOC106781434
uniprot id: F7DFI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:UBE2D1
gene id: 9796:UBE2D1
uniprot id: A0A3Q2KWY6
uniprot id: A0A5F5PPN9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9796:GOSR1
gene id: 9796:GOSR1
uniprot id: F6YYT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9796:PTH
gene id: 9796:PTH
uniprot id: Q27IM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
messages: Secreted

9796:PARN
gene id: 9796:PARN
uniprot id: F6Q3J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm
messages: Nucleus

9796:XIAP
gene id: 9796:XIAP
uniprot id: F7BTS0
names: Similarity
messages: Belongs to the IAP family.

9796:PSMD1
gene id: 9796:PSMD1
uniprot id: F6S5X4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9796:LOC100053760
gene id: 9796:LOC100053760
uniprot id: A0A3Q2I6W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:AREL1
gene id: 9796:AREL1
uniprot id: F7BTE5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:LOC100070293
gene id: 9796:LOC100070293
uniprot id: A0A3Q2I527
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CD200
gene id: 9796:CD200
uniprot id: A0A3Q2HAV0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:GLO1
gene id: 9796:GLO1
uniprot id: F7CHI7
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9796:BID
gene id: 9796:BID
uniprot id: F7A8I6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Membrane
messages: Mitochondrion outer membrane

9796:ALCAM
gene id: 9796:ALCAM
uniprot id: A0A3Q2GZ81
uniprot id: F7B5L3
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9796:PPARD
gene id: 9796:PPARD
uniprot id: F6WAT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9796:MED8
gene id: 9796:MED8
uniprot id: F6SFZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9796:IL20
gene id: 9796:IL20
uniprot id: A0A7R8C3Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9796:LOC100050529
gene id: 9796:LOC100050529
uniprot id: F6SUA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9796:RAD52
gene id: 9796:RAD52
uniprot id: F7AVC4
names: Similarity
messages: Belongs to the RAD52 family.

9796:LOC100072254
gene id: 9796:LOC100072254
uniprot id: A0A3Q2HAJ4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SLC22A4
gene id: 9796:SLC22A4
uniprot id: F6YQW8
names: Subunit
messages: Interacts with PDZK1.

9796:LOC100068867
gene id: 9796:LOC100068867
uniprot id: F7C4C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GSG1
gene id: 9796:GSG1
uniprot id: A0A3Q2I270
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9796:GDF9
gene id: 9796:GDF9
uniprot id: F6VWE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9796:PSMA4
gene id: 9796:PSMA4
uniprot id: F6Z688
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9796:LOC100066640
gene id: 9796:LOC100066640
uniprot id: A0A3Q2HZG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RARS
gene id: 9796:RARS
uniprot id: F6YPN7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9796:SCML4
gene id: 9796:SCML4
uniprot id: A0A3Q2HG08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9796:CHAF1B
gene id: 9796:CHAF1B
uniprot id: F6U7T6
names: Subcellular Location Annotation
messages: Nucleus

9796:CAPN6
gene id: 9796:CAPN6
uniprot id: F6ZMP5
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:MTMR3
gene id: 9796:MTMR3
uniprot id: A0A3Q2HWU2
uniprot id: A0A3Q2I8Y5
uniprot id: A0A3Q2IJ92
uniprot id: F7CGU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9796:UTS2R
gene id: 9796:UTS2R
uniprot id: F6RZK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

9796:TCN2
gene id: 9796:TCN2
uniprot id: F6U5V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9796:NOTCH4
gene id: 9796:NOTCH4
uniprot id: F6PHD6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9796:WASF3
gene id: 9796:WASF3
uniprot id: F7D4Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9796:GLRA1
gene id: 9796:GLRA1
uniprot id: F6UQM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

9796:LOC100629456
gene id: 9796:LOC100629456
uniprot id: Q0W9P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria.
messages: Secreted

9796:CCL24
gene id: 9796:CCL24
uniprot id: A0A3Q2KVU7
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9796:RELL1
gene id: 9796:RELL1
uniprot id: A0A3Q2L9I5
uniprot id: F6V8T3
names: Similarity
messages: Belongs to the RELT family.

9796:ECSIT
gene id: 9796:ECSIT
uniprot id: F6YXE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

9796:TFPI2
gene id: 9796:TFPI2
uniprot id: F6V7B1
names: Subcellular Location Annotation
messages: Secreted

9796:TTC3
gene id: 9796:TTC3
uniprot id: F6TK13
names: Subcellular Location Annotation
messages: Cytoplasm

9796:UMOD
gene id: 9796:UMOD
uniprot id: F7BN45
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

9796:BCKDHA
gene id: 9796:BCKDHA
uniprot id: F6REC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of alpha and beta chains.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

9796:NOSIP
gene id: 9796:NOSIP
uniprot id: F6SN22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

9796:KRT23
gene id: 9796:KRT23
uniprot id: A0A3Q2KP58
names: Similarity
messages: Belongs to the intermediate filament family.

9796:GCDH
gene id: 9796:GCDH
uniprot id: F6S9W0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9796:IL18
gene id: 9796:IL18
uniprot id: B1AB85
uniprot id: Q9XSQ7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.

9796:LOC100068322
gene id: 9796:LOC100068322
uniprot id: A0A5F5PKQ2
uniprot id: F7CRD9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9796:ADIPOR1
gene id: 9796:ADIPOR1
uniprot id: F6XSB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9796:MAOA
gene id: 9796:MAOA
uniprot id: Q5NU32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

9796:CXCR3
gene id: 9796:CXCR3
uniprot id: F6U4S6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

9796:CD40LG
gene id: 9796:CD40LG
uniprot id: A0A5F5PNZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

9796:LOC100056905
gene id: 9796:LOC100056905
uniprot id: F6R2Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RAB3IP
gene id: 9796:RAB3IP
uniprot id: A0A5F5PU67
names: Similarity
messages: Belongs to the SEC2 family.

9796:USP45
gene id: 9796:USP45
uniprot id: A0A5F5PUG3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9796:CCDC58
gene id: 9796:CCDC58
uniprot id: F7C2U3
names: Similarity
messages: Belongs to the MIX23 family.

9796:EXTL3
gene id: 9796:EXTL3
uniprot id: A0A3Q2I4P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:AMIGO1
gene id: 9796:AMIGO1
uniprot id: F6X0F6
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9796:LOC100067869
gene id: 9796:LOC100067869
uniprot id: F6XWM5
names: Caution
names: Function
names: Similarity
messages: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:HDAC7
gene id: 9796:HDAC7
uniprot id: A0A3Q2HYC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9796:OLFML3
gene id: 9796:OLFML3
uniprot id: F7BCM8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:LOC100061784
gene id: 9796:LOC100061784
uniprot id: F6Q494
names: Subcellular Location Annotation
messages: Cytoplasm

9796:CNN3
gene id: 9796:CNN3
uniprot id: F7DCH4
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9796:SH3BGRL3
gene id: 9796:SH3BGRL3
uniprot id: A0A0B4J1B8
names: Similarity
messages: Belongs to the SH3BGR family.

9796:APOO
gene id: 9796:APOO
uniprot id: F7AGU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9796:PLAU
gene id: 9796:PLAU
uniprot id: F7BT48
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9796:P2RX1
gene id: 9796:P2RX1
uniprot id: F6S8X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9796:LOC100072392
gene id: 9796:LOC100072392
uniprot id: A0A3Q2IAK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SLC24A5
gene id: 9796:SLC24A5
uniprot id: A0A3Q2HAS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9796:GNG12
gene id: 9796:GNG12
uniprot id: A0A3Q2I997
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9796:SETDB1
gene id: 9796:SETDB1
uniprot id: A0A3Q2L3N4
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9796:PEX14
gene id: 9796:PEX14
uniprot id: F6SDL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

9796:KIF2B
gene id: 9796:KIF2B
uniprot id: F6W9I6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:NAA11
gene id: 9796:NAA11
uniprot id: A0A3Q2HRD2
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9796:PPM1K
gene id: 9796:PPM1K
uniprot id: F6Q474
names: Similarity
messages: Belongs to the PP2C family.

9796:HNRNPUL1
gene id: 9796:HNRNPUL1
uniprot id: F6X440
names: Subcellular Location Annotation
messages: Nucleus

9796:ETS1
gene id: 9796:ETS1
uniprot id: A0A3Q2HHV2
uniprot id: A0A3Q2I2Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9796:EXO1
gene id: 9796:EXO1
uniprot id: A0A3Q2HD49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9796:PLAGL2
gene id: 9796:PLAGL2
uniprot id: F6VAD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9796:PRR5L
gene id: 9796:PRR5L
uniprot id: F7E185
names: Similarity
messages: Belongs to the PROTOR family.

9796:VPS52
gene id: 9796:VPS52
uniprot id: F7CG57
names: Similarity
messages: Belongs to the VPS52 family.

9796:TPH2
gene id: 9796:TPH2
uniprot id: Q0EAB8
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9796:TPRKB
gene id: 9796:TPRKB
uniprot id: F7DJK5
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9796:RPS27
gene id: 9796:RPS27
uniprot id: A0A3Q2KU37
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9796:RIPOR2
gene id: 9796:RIPOR2
uniprot id: A0A3Q2LP96
uniprot id: F6ZKB5
uniprot id: F7BEY0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: stereocilium membrane

9796:LYRM7
gene id: 9796:LYRM7
uniprot id: K9K4D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9796:TSPAN31
gene id: 9796:TSPAN31
uniprot id: F6RUF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9796:LOC100056411
gene id: 9796:LOC100056411
uniprot id: A0A5F5PIR5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9796:LOC100068803
gene id: 9796:LOC100068803
uniprot id: A0A3Q2GU39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FDPS
gene id: 9796:FDPS
uniprot id: A0A5F5PXG1
uniprot id: K9K3N0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9796:GRPEL2
gene id: 9796:GRPEL2
uniprot id: F6YRH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9796:RSPO1
gene id: 9796:RSPO1
uniprot id: A8C9U0
names: Similarity
messages: Belongs to the R-spondin family.

9796:RAB3A
gene id: 9796:RAB3A
uniprot id: F6VA27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9796:ATP6V0A1
gene id: 9796:ATP6V0A1
uniprot id: F7AYG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9796:SCNM1
gene id: 9796:SCNM1
uniprot id: F6WMF6
names: Function
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
messages: nucleoplasm

9796:BPGM
gene id: 9796:BPGM
uniprot id: F7CB51
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9796:FTL
gene id: 9796:FTL
uniprot id: P02791
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: In horse spleen the light chain is the major chain.
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

9796:PLSCR1
gene id: 9796:PLSCR1
uniprot id: F6S4G6
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9796:QKI
gene id: 9796:QKI
uniprot id: Q5W9D6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity).
messages: Methylated by PRMT1.
messages: Nucleus
messages: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
messages: The KH domain and the Qua2 region are involved in RNA binding.
messages: Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).

9796:ACSM4
gene id: 9796:ACSM4
uniprot id: F6XXC2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9796:MRPL51
gene id: 9796:MRPL51
uniprot id: F7AH48
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

9796:BBOX1
gene id: 9796:BBOX1
uniprot id: F6PZ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
messages: Cytoplasm

9796:ITPRIP
gene id: 9796:ITPRIP
uniprot id: F7B7M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Cell membrane
messages: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
messages: Membrane
messages: Nucleus outer membrane

9796:C10H19orf12
gene id: 9796:C10H19orf12
uniprot id: A0A3Q2HA47
uniprot id: A0A3Q2LKJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

9796:POP7
gene id: 9796:POP7
uniprot id: F6S2S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9796:DLX5
gene id: 9796:DLX5
uniprot id: F7DY45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9796:ZNF174
gene id: 9796:ZNF174
uniprot id: A0A5F5PZK1
uniprot id: F6T5P3
names: Subcellular Location Annotation
messages: Nucleus

9796:TMEM107
gene id: 9796:TMEM107
uniprot id: F6ZQI0
names: Subcellular Location Annotation
messages: Membrane

9796:TBCE
gene id: 9796:TBCE
uniprot id: K9K4M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

9796:ALDOC
gene id: 9796:ALDOC
uniprot id: F6ZP69
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9796:TMSB10
gene id: 9796:TMSB10
uniprot id: P63314
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
messages: cytoskeleton

9796:LOC100050632
gene id: 9796:LOC100050632
uniprot id: A0A3Q2HYM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LMF2
gene id: 9796:LMF2
uniprot id: F6TFW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

9796:OSGEP
gene id: 9796:OSGEP
uniprot id: F7C4W2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Cytoplasm
messages: Nucleus

9796:ITIH2
gene id: 9796:ITIH2
uniprot id: F7DAF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9796:PREPL
gene id: 9796:PREPL
uniprot id: F7B4K4
names: Similarity
messages: Belongs to the peptidase S9A family.

9796:LOC100066690
gene id: 9796:LOC100066690
uniprot id: F6WNB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:VAMP7
gene id: 9796:VAMP7
uniprot id: F7AIZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9796:SRRT
gene id: 9796:SRRT
uniprot id: F6SGX1
names: Similarity
messages: Belongs to the ARS2 family.

9796:GDAP1
gene id: 9796:GDAP1
uniprot id: F7BBX2
names: Similarity
messages: Belongs to the GST superfamily.

9796:SCG3
gene id: 9796:SCG3
uniprot id: F6YLI2
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: secretory vesicle membrane

9796:DYNLT3
gene id: 9796:DYNLT3
uniprot id: F6RHT2
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9796:TNPO2
gene id: 9796:TNPO2
uniprot id: F7D587
names: Subcellular Location Annotation
messages: Cytoplasm

9796:SEMA3E
gene id: 9796:SEMA3E
uniprot id: F7DIP3
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:ADPRM
gene id: 9796:ADPRM
uniprot id: F6SNJ9
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9796:PGM2L1
gene id: 9796:PGM2L1
uniprot id: F7B0A8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9796:GFRA3
gene id: 9796:GFRA3
uniprot id: F6WYV4
names: Similarity
messages: Belongs to the GDNFR family.

9796:CWC25
gene id: 9796:CWC25
uniprot id: F7A8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9796:ENOPH1
gene id: 9796:ENOPH1
uniprot id: F7D9G5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9796:MMP26
gene id: 9796:MMP26
uniprot id: A0A3Q2I1S9
names: Similarity
messages: Belongs to the peptidase M10A family.

9796:MRPL36
gene id: 9796:MRPL36
uniprot id: F7DW74
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9796:LOC100071657
gene id: 9796:LOC100071657
uniprot id: F6Z408
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9796:LOC100072707
gene id: 9796:LOC100072707
uniprot id: W0UV07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9796:ZNF280C
gene id: 9796:ZNF280C
uniprot id: A0A3Q2KM00
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9796:C7H19orf70
gene id: 9796:C7H19orf70
uniprot id: F6R4Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9796:PTPN14
gene id: 9796:PTPN14
uniprot id: F6VJ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9796:EDNRB
gene id: 9796:EDNRB
uniprot id: F6PYK5
uniprot id: O62709
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
messages: Cell membrane
messages: Defects in EDNRB are a cause of overo lethal white syndrome (OLWS) also known as lethal white foal syndrome (LWFS). It is an inherited syndrome of foals born to American paint horse parents of the overo coat-pattern lineage. Affected foals are totally or almost totally white and die within days from complications due to intestinal aganglionosis.
messages: Membrane
messages: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9796:OST4
gene id: 9796:OST4
uniprot id: A0A5F5PQR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:GLRA4
gene id: 9796:GLRA4
uniprot id: F6RNW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9796:TSG101
gene id: 9796:TSG101
uniprot id: F6ZA94
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

9796:UBE2H
gene id: 9796:UBE2H
uniprot id: A0A3Q2I9D8
uniprot id: F6TMW7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9796:LOC100056866
gene id: 9796:LOC100056866
uniprot id: F7D0X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GPR180
gene id: 9796:GPR180
uniprot id: A0A3Q2GUR7
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100071714
gene id: 9796:LOC100071714
uniprot id: F6YD73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9796:LIG4
gene id: 9796:LIG4
uniprot id: F6X700
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9796:RPS5
gene id: 9796:RPS5
uniprot id: A0A5F5PQJ7
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9796:THOC6
gene id: 9796:THOC6
uniprot id: F6WVU2
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9796:SERF2
gene id: 9796:SERF2
uniprot id: A0A3Q2KIX4
names: Similarity
messages: Belongs to the SERF family.

9796:TAGLN
gene id: 9796:TAGLN
uniprot id: A8J714
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

9796:CTNNA3
gene id: 9796:CTNNA3
uniprot id: F6TJV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: cytoskeleton

9796:ELOVL5
gene id: 9796:ELOVL5
uniprot id: A0A3Q2I0Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

9796:BCDIN3D
gene id: 9796:BCDIN3D
uniprot id: F6WC50
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9796:LOC100072158
gene id: 9796:LOC100072158
uniprot id: A0A3Q2KXD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:EMSY
gene id: 9796:EMSY
uniprot id: A0A3Q2GUN8
uniprot id: A0A5F5Q4F5
uniprot id: F7DLF3
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100056786
gene id: 9796:LOC100056786
uniprot id: F6SPM5
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9796:MGST1
gene id: 9796:MGST1
uniprot id: F6U8C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9796:ENPP6
gene id: 9796:ENPP6
uniprot id: F7B9I7
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

9796:ITGA8
gene id: 9796:ITGA8
uniprot id: F7BGF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9796:KLK1E2
gene id: 9796:KLK1E2
uniprot id: Q6H321
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S1 family. Kallikrein subfamily.
messages: Detected in prostate and semen.
messages: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
messages: Secreted

9796:LOC100050174
gene id: 9796:LOC100050174
uniprot id: F7CJK2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9796:CYB5R2
gene id: 9796:CYB5R2
uniprot id: A0A3Q2L6D6
uniprot id: F7DV24
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9796:DDX5
gene id: 9796:DDX5
uniprot id: F6ZKZ4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9796:FRK
gene id: 9796:FRK
uniprot id: F6RRJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9796:LOC100059435
gene id: 9796:LOC100059435
uniprot id: F7A6T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ASIC2
gene id: 9796:ASIC2
uniprot id: E1A462
names: Subcellular Location Annotation
messages: Membrane

9796:ZSCAN2
gene id: 9796:ZSCAN2
uniprot id: F6SYS6
uniprot id: F7BK88
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9796:THBS1
gene id: 9796:THBS1
uniprot id: F6YR34
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:HSPA8
gene id: 9796:HSPA8
uniprot id: A2Q0Z1
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated.
messages: Belongs to the heat shock protein 70 family.
messages: Cell membrane
messages: Constitutively synthesized.
messages: Cytoplasm
messages: ISGylated.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Interacts with PACRG (By similarity). Interacts with HSPH1/HSP105 (By similarity). Interacts with IRAK1BP1 and BAG1 (By similarity). Interacts with DNAJC7 (By similarity). Interacts with DNAJB12 (via J domain) (By similarity). Interacts with DNAJB14 (via J domain) (By similarity). Interacts (via C-terminus) with the E3 ligase STUB1 forming a 210 kDa complex of one STUB1 and two HSPA8 molecules (By similarity). Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation (By similarity). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (By similarity). Interacts with TRIM5 (By similarity). Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity). Interacts with METTL21A (By similarity). Following LPS binding, may form a complex with CXCR4, GDF5 and HSP90AA1 (By similarity). Interacts with PRKN (By similarity). Interacts with FOXP3 (By similarity). Interacts with DNAJC9 (via J domain) (By similarity). Interacts with MLLT11 (By similarity). Interacts with RNF207 (By similarity). Interacts with DNAJC21 (By similarity). Interacts with DNAJB2 (By similarity). Interacts with TTC1 (via TPR repeats) (By similarity). Interacts with SGTA (via TPR repeats) (By similarity). Interacts with HSF1 (via transactivation domain) (By similarity). Interacts with HOPX, STUB1, HSP40, HSP901, BAG2 and BAG3 (By similarity). Interacts with HSPC138 (By similarity). Interacts with ZMYND10 (By similarity). Interacts with VGF-derived peptide TLQP-21 (By similarity). Interacts with BCL2L1, GIMAP5 and MC…
messages: Melanosome
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.…
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
messages: Trimethylation at Lys-561 reduces fibrillar SNCA binding.
messages: nucleolus

9796:SH3PXD2A
gene id: 9796:SH3PXD2A
uniprot id: A0A3Q2L334
uniprot id: F6XS93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm
messages: podosome

9796:UBR2
gene id: 9796:UBR2
uniprot id: A0A3Q2HX42
uniprot id: F6U471
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9796:IL1RAP
gene id: 9796:IL1RAP
uniprot id: F7ASE1
uniprot id: F7AWQ9
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9796:TMEM53
gene id: 9796:TMEM53
uniprot id: A0A5F5Q4B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9796:CASTOR2
gene id: 9796:CASTOR2
uniprot id: F6ZCP8
names: Similarity
messages: Belongs to the GATS family.

9796:MAX
gene id: 9796:MAX
uniprot id: A0A3Q2IBA9
names: Similarity
messages: Belongs to the MAX family.

9796:SEMA3A
gene id: 9796:SEMA3A
uniprot id: F6R988
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:TIMM17B
gene id: 9796:TIMM17B
uniprot id: A0A5F5PWK5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

9796:RARG
gene id: 9796:RARG
uniprot id: A0A3Q2I9L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9796:LOC100067396
gene id: 9796:LOC100067396
uniprot id: A0A3Q2HIK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FAM3B
gene id: 9796:FAM3B
uniprot id: A0A3Q2I398
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9796:CYP2C113
gene id: 9796:CYP2C113
uniprot id: W8W0T9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9796:DNAAF4
gene id: 9796:DNAAF4
uniprot id: A0A5F5PL24
uniprot id: F6ZNG0
names: Subcellular Location Annotation
messages: Dynein axonemal particle
messages: neuron projection

9796:C6H12orf57
gene id: 9796:C6H12orf57
uniprot id: F6Q737
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

9796:SLC10A5
gene id: 9796:SLC10A5
uniprot id: F6PK40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9796:HPD
gene id: 9796:HPD
uniprot id: F7BER4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9796:PARVG
gene id: 9796:PARVG
uniprot id: F6VS59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9796:LOC100054214
gene id: 9796:LOC100054214
uniprot id: A0A3Q2L8V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:KCNJ15
gene id: 9796:KCNJ15
uniprot id: F6T921
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9796:NCEH1
gene id: 9796:NCEH1
uniprot id: F6R609
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9796:KIAA1024
gene id: 9796:KIAA1024
uniprot id: A0A3Q2I9N2
names: Similarity
messages: Belongs to the MINAR family.

9796:PDE4B
gene id: 9796:PDE4B
uniprot id: A0A5F5PLJ4
uniprot id: F6ZL60
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9796:LOC100070352
gene id: 9796:LOC100070352
uniprot id: F7DJI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9796:LPAR6
gene id: 9796:LPAR6
uniprot id: F6SPW5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:CLDN34
gene id: 9796:CLDN34
uniprot id: F6Q4B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9796:LOC100050381
gene id: 9796:LOC100050381
uniprot id: F7CR82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SLC2A3
gene id: 9796:SLC2A3
uniprot id: A0A3Q2HM94
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9796:DIMT1
gene id: 9796:DIMT1
uniprot id: F7BAA7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9796:ARHGEF6
gene id: 9796:ARHGEF6
uniprot id: F6REK1
names: Subcellular Location Annotation
messages: lamellipodium

9796:TRAPPC4
gene id: 9796:TRAPPC4
uniprot id: A0A5F5PGX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9796:AGBL5
gene id: 9796:AGBL5
uniprot id: F7BT54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Midbody
messages: Nucleus
messages: cytosol
messages: spindle

9796:LOC100050599
gene id: 9796:LOC100050599
uniprot id: F6Q064
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9796:GSKIP
gene id: 9796:GSKIP
uniprot id: F6WH47
names: Similarity
messages: Belongs to the GSKIP family.

9796:LOC100058927
gene id: 9796:LOC100058927
uniprot id: F6ZGC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:IL4
gene id: 9796:IL4
uniprot id: A7LBR9
uniprot id: P42202
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
messages: Secreted

9796:AIF1
gene id: 9796:AIF1
uniprot id: F7BN52
names: Subcellular Location Annotation
messages: ruffle membrane

9796:MSR1
gene id: 9796:MSR1
uniprot id: A0A3Q2HSD0
names: Subcellular Location Annotation
messages: Membrane

9796:ZFP36L1
gene id: 9796:ZFP36L1
uniprot id: F7AV26
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9796:HMBOX1
gene id: 9796:HMBOX1
uniprot id: A0A5F5PW47
uniprot id: F6V2F8
names: Subcellular Location Annotation
messages: Nucleus

9796:TRIM36
gene id: 9796:TRIM36
uniprot id: A0A3Q2I6N9
names: Subcellular Location Annotation
messages: cytoskeleton

9796:FAM124B
gene id: 9796:FAM124B
uniprot id: F7DQ23
names: Similarity
messages: Belongs to the FAM124 family.

9796:LOC100067439
gene id: 9796:LOC100067439
uniprot id: A0A3Q2KJ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9796:IL17RA
gene id: 9796:IL17RA
uniprot id: F6XT99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:UTP14A
gene id: 9796:UTP14A
uniprot id: F6UWY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9796:PIANP
gene id: 9796:PIANP
uniprot id: F6VYZ6
names: Subcellular Location Annotation
messages: Membrane

9796:PRKCE
gene id: 9796:PRKCE
uniprot id: F6XZ82
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

9796:ZDHHC15
gene id: 9796:ZDHHC15
uniprot id: A0A3Q2L2E6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9796:LOC100052081
gene id: 9796:LOC100052081
uniprot id: F6Q015
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9796:NAGK
gene id: 9796:NAGK
uniprot id: F7AGH6
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9796:PCNA
gene id: 9796:PCNA
uniprot id: F6R950
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9796:HSPB3
gene id: 9796:HSPB3
uniprot id: F6PKL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9796:TPM2
gene id: 9796:TPM2
uniprot id: A0A3Q2H546
uniprot id: A0A3Q2ID93
uniprot id: F7A281
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9796:IFN-OMEGA2
gene id: 9796:IFN-OMEGA2
uniprot id: F7AD69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:SMIM22
gene id: 9796:SMIM22
uniprot id: A0A5F5PNK8
names: Subcellular Location Annotation
messages: Membrane

9796:CDK7
gene id: 9796:CDK7
uniprot id: K9K3U4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9796:ATP6V1H
gene id: 9796:ATP6V1H
uniprot id: A0A3Q2HMJ9
uniprot id: A0A3Q2IGC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9796:MOCS2
gene id: 9796:MOCS2
uniprot id: F6S763
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9796:IL6
gene id: 9796:IL6
uniprot id: Q95181
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).
messages: Secreted

9796:DPEP2
gene id: 9796:DPEP2
uniprot id: F6PT98
names: Subcellular Location Annotation
messages: Membrane

9796:SNRPD2
gene id: 9796:SNRPD2
uniprot id: F7CK08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

9796:HSF4
gene id: 9796:HSF4
uniprot id: F6XGH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9796:ALG5
gene id: 9796:ALG5
uniprot id: F6RYM5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9796:CXCL11
gene id: 9796:CXCL11
uniprot id: F6QHU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9796:CHIT1
gene id: 9796:CHIT1
uniprot id: B7S833
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9796:ALDH6A1
gene id: 9796:ALDH6A1
uniprot id: F6Z1Y2
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9796:NDUFV3
gene id: 9796:NDUFV3
uniprot id: A0A3Q2LSK6
uniprot id: F6YSA4
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

9796:NACC1
gene id: 9796:NACC1
uniprot id: A0A3Q2IAI6
names: Subcellular Location Annotation
messages: Nucleus

9796:LYPLAL1
gene id: 9796:LYPLAL1
uniprot id: F6RMH7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9796:SLC2A1
gene id: 9796:SLC2A1
uniprot id: A0A3Q2HV80
uniprot id: F7CBT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Membrane
messages: Photoreceptor inner segment

9796:LOC100068050
gene id: 9796:LOC100068050
uniprot id: F6QCH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100058290
gene id: 9796:LOC100058290
uniprot id: F6SA20
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9796:TNFAIP1
gene id: 9796:TNFAIP1
uniprot id: F6PH15
names: Similarity
messages: Belongs to the BACURD family.

9796:SLC30A5
gene id: 9796:SLC30A5
uniprot id: A0A3Q2I7W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9796:ADCY8
gene id: 9796:ADCY8
uniprot id: F6R859
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9796:WNT2B
gene id: 9796:WNT2B
uniprot id: F6ZFX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9796:LOC100056182
gene id: 9796:LOC100056182
uniprot id: F7E2N0
names: Similarity
messages: Belongs to the MHC class I family.

9796:NPSR1
gene id: 9796:NPSR1
uniprot id: F6QT90
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:JUNB
gene id: 9796:JUNB
uniprot id: F6Y5A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9796:ANAPC10
gene id: 9796:ANAPC10
uniprot id: F6X9H3
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9796:ACMSD
gene id: 9796:ACMSD
uniprot id: A0A3Q2HMM7
uniprot id: F6PWP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9796:PIP
gene id: 9796:PIP
uniprot id: F6V6R7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.
messages: Secreted

9796:LOC100050719
gene id: 9796:LOC100050719
uniprot id: F6UGQ4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9796:SLX4
gene id: 9796:SLX4
uniprot id: F7CSW5
names: Similarity
messages: Belongs to the SLX4 family.

9796:SMARCD2
gene id: 9796:SMARCD2
uniprot id: F7BEP7
names: Similarity
messages: Belongs to the SMARCD family.

9796:IFT46
gene id: 9796:IFT46
uniprot id: A0A3Q2I0H0
uniprot id: F7CNC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9796:KRT222
gene id: 9796:KRT222
uniprot id: F6S882
names: Similarity
messages: Belongs to the intermediate filament family.

9796:DTX3
gene id: 9796:DTX3
uniprot id: F6TMV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9796:ANAPC13
gene id: 9796:ANAPC13
uniprot id: A0A3Q2IAI5
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9796:INO80
gene id: 9796:INO80
uniprot id: F6UT07
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9796:ATAT1
gene id: 9796:ATAT1
uniprot id: F7DFQ9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

9796:PRM1
gene id: 9796:PRM1
uniprot id: P15341
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Cross-linked by interchain disulfide bonds around the DNA-helix.
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Testis.

9796:DCK
gene id: 9796:DCK
uniprot id: F6X3X8
names: Similarity
messages: Belongs to the DCK/DGK family.

9796:TP53
gene id: 9796:TP53
uniprot id: E9NME8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9796:LOC100070635
gene id: 9796:LOC100070635
uniprot id: F6ZFX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ZFX
gene id: 9796:ZFX
uniprot id: A0A3Q2I0G1
names: Subcellular Location Annotation
messages: Nucleus

9796:NLE1
gene id: 9796:NLE1
uniprot id: F7AQE9
names: Subcellular Location Annotation
messages: nucleolus

9796:ADRA2B
gene id: 9796:ADRA2B
uniprot id: A0A2C9CWS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Membrane

9796:DMRT3
gene id: 9796:DMRT3
uniprot id: F6W2R2
names: Domain
names: Function
names: Miscellaneous
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DMRT family.
messages: DMA domain interacts with ubiquitin.
messages: DMRT3 is a marker for a subset of spinal cord neurons (dI6).
messages: Expressed in the spinal cord, in a small population of neurons located in the ventral horn and around the central canal.
messages: Nucleus
messages: Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.
messages: This sequence corresponds to the wild-type form. A truncated allele, allele A (AC J7FCF0), is linked to the ability to perform alternate gaits, which can be either pace or four-beat ambling gaits. The allele A sequence (AC J7FCF0) has a favorable effect on harness racing performance and on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation. Homozygosity for the mutation is required, but not sufficient for pacing, as many Standardbred trotters and some Icelandic horses that are homozygous for this mutation do not pace. The allele A is not found in the following horse populations: Arabian horse, Gotland pony, North-Swedish draft horse, Przewalski's horse, Shetland pony, Swedish ardennes, Swedish warmblood and Thoroughbred.

9796:LOC100058582
gene id: 9796:LOC100058582
uniprot id: F6PPX7
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9796:TAZ
gene id: 9796:TAZ
uniprot id: F7C1G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9796:COA5
gene id: 9796:COA5
uniprot id: A0A5F5PKV9
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9796:MCM5
gene id: 9796:MCM5
uniprot id: F7D4R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9796:ZDHHC21
gene id: 9796:ZDHHC21
uniprot id: F7CCG8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9796:NAALADL2
gene id: 9796:NAALADL2
uniprot id: A0A3Q2GXA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Membrane

9796:MVD
gene id: 9796:MVD
uniprot id: F6ZMR1
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

9796:SLC12A1
gene id: 9796:SLC12A1
uniprot id: A0A3Q2H8M6
uniprot id: A0A5K1V901
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9796:HSP90B1
gene id: 9796:HSP90B1
uniprot id: F6ZUJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9796:LOC100071999
gene id: 9796:LOC100071999
uniprot id: A0A3Q2IGB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RPTOR
gene id: 9796:RPTOR
uniprot id: F6QCM0
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9796:YWHAQ
gene id: 9796:YWHAQ
uniprot id: F6SP02
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
messages: Belongs to the 14-3-3 family.

9796:LOC100059730
gene id: 9796:LOC100059730
uniprot id: A0A3Q2L5K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100068603
gene id: 9796:LOC100068603
uniprot id: L8B938
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:SIX1
gene id: 9796:SIX1
uniprot id: F6W7Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

9796:CLDN10
gene id: 9796:CLDN10
uniprot id: F6SEC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:ACER2
gene id: 9796:ACER2
uniprot id: F6XSP1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:B3GALNT1
gene id: 9796:B3GALNT1
uniprot id: A0A3Q2HC48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:SARS
gene id: 9796:SARS
uniprot id: A0A3Q2GVC4
uniprot id: F7BTP3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9796:ANKRD13C
gene id: 9796:ANKRD13C
uniprot id: A0A3Q2HAR9
names: Subcellular Location Annotation
messages: Membrane

9796:KDM4C
gene id: 9796:KDM4C
uniprot id: F6XAR3
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9796:MGST2
gene id: 9796:MGST2
uniprot id: F7AUV5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9796:YME1L1
gene id: 9796:YME1L1
uniprot id: F7DPJ7
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9796:PDE6D
gene id: 9796:PDE6D
uniprot id: F7AAZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9796:MYH1
gene id: 9796:MYH1
uniprot id: Q8MJV0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9796:HACD4
gene id: 9796:HACD4
uniprot id: A0A3Q2HZS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:ZDHHC22
gene id: 9796:ZDHHC22
uniprot id: F6SFZ8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9796:SLC37A1
gene id: 9796:SLC37A1
uniprot id: F6VY39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9796:BUD31
gene id: 9796:BUD31
uniprot id: F6XUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9796:TRMT61A
gene id: 9796:TRMT61A
uniprot id: F6RVB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9796:FAM163A
gene id: 9796:FAM163A
uniprot id: F6UBC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9796:HAP1
gene id: 9796:HAP1
uniprot id: A0A3Q2KR03
names: Subcellular Location Annotation
messages: Early endosome
messages: Mitochondrion

9796:DGUOK
gene id: 9796:DGUOK
uniprot id: A0A5F5PN83
uniprot id: F7APZ2
names: Similarity
messages: Belongs to the DCK/DGK family.

9796:LOC100146977
gene id: 9796:LOC100146977
uniprot id: F6Q8W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9796:BSG
gene id: 9796:BSG
uniprot id: A5JST8
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lateral cell membrane

9796:GC
gene id: 9796:GC
uniprot id: F6T0P6
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9796:UGGT2
gene id: 9796:UGGT2
uniprot id: F6TI49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9796:CCS
gene id: 9796:CCS
uniprot id: F6UQH5
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9796:KIF24
gene id: 9796:KIF24
uniprot id: F6PTT0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:ST3GAL1
gene id: 9796:ST3GAL1
uniprot id: F6Q8K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9796:LOC100057054
gene id: 9796:LOC100057054
uniprot id: F6XFQ1
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9796:SH2B1
gene id: 9796:SH2B1
uniprot id: A0A3Q2H328
names: Similarity
messages: Belongs to the SH2B adapter family.

9796:MAPT
gene id: 9796:MAPT
uniprot id: A0A3Q2GRN1
uniprot id: A0A3Q2L6A1
uniprot id: F6Y4B0
names: Subcellular Location Annotation
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol

9796:LOC100057500
gene id: 9796:LOC100057500
uniprot id: A0A3Q2HX18
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

9796:ST3GAL2
gene id: 9796:ST3GAL2
uniprot id: F6Y8U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9796:GPR20
gene id: 9796:GPR20
uniprot id: F7A186
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:CXCL9
gene id: 9796:CXCL9
uniprot id: B1AB89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9796:HOXA1
gene id: 9796:HOXA1
uniprot id: F6YY78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9796:TRAPPC9
gene id: 9796:TRAPPC9
uniprot id: A0A5F5PQ86
uniprot id: A0A5F5Q0P9
uniprot id: F6WZ99
names: Similarity
messages: Belongs to the NIBP family.

9796:NRP2
gene id: 9796:NRP2
uniprot id: A0A3Q2L3R9
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:DLC1
gene id: 9796:DLC1
uniprot id: A0A3Q2H4H8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
messages: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.
messages: Membrane
messages: focal adhesion

9796:ELP6
gene id: 9796:ELP6
uniprot id: F6YY26
names: Similarity
messages: Belongs to the ELP6 family.

9796:SMARCA1
gene id: 9796:SMARCA1
uniprot id: F6SMK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9796:SSR4
gene id: 9796:SSR4
uniprot id: F6V3K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9796:COPS4
gene id: 9796:COPS4
uniprot id: A0A3Q2I1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9796:HR
gene id: 9796:HR
uniprot id: F7BI66
names: Subcellular Location Annotation
messages: Nucleus

9796:NDUFV1
gene id: 9796:NDUFV1
uniprot id: A0A3Q2H8Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9796:LIPH
gene id: 9796:LIPH
uniprot id: F7AM73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9796:RPL35
gene id: 9796:RPL35
uniprot id: A0A5F5PZ86
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9796:SLC6A14
gene id: 9796:SLC6A14
uniprot id: F6WG98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9796:GSTM3
gene id: 9796:GSTM3
uniprot id: F7BKK5
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9796:EQMHCC1
gene id: 9796:EQMHCC1
uniprot id: Q30486
names: Similarity
messages: Belongs to the MHC class I family.

9796:DLAT
gene id: 9796:DLAT
uniprot id: F6XVX2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9796:PPP2CB
gene id: 9796:PPP2CB
uniprot id: F7AEP1
names: Similarity
messages: Belongs to the PPP phosphatase family.

9796:LOC100060186
gene id: 9796:LOC100060186
uniprot id: A0A1W1GCG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9796:MSTO1
gene id: 9796:MSTO1
uniprot id: F6Q188
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

9796:CDPF1
gene id: 9796:CDPF1
uniprot id: F7DQK5
names: Similarity
messages: Belongs to the CDPF1 family.

9796:CLDN2
gene id: 9796:CLDN2
uniprot id: F6YS83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:SPATS2L
gene id: 9796:SPATS2L
uniprot id: A0A5F5PM17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

9796:LOC100070687
gene id: 9796:LOC100070687
uniprot id: F6QNB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100057811
gene id: 9796:LOC100057811
uniprot id: F7DB40
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SLC37A3
gene id: 9796:SLC37A3
uniprot id: A0A3Q2GZM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9796:GRIK2
gene id: 9796:GRIK2
uniprot id: A0A3Q2LM99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9796:AGTR2
gene id: 9796:AGTR2
uniprot id: F7AV47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

9796:GJB3
gene id: 9796:GJB3
uniprot id: A0A654ICQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:CENPBD1
gene id: 9796:CENPBD1
uniprot id: A0A3Q2L6R4
names: Subcellular Location Annotation
messages: Nucleus

9796:RIDA
gene id: 9796:RIDA
uniprot id: F7A6J6
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

9796:ANTXR2
gene id: 9796:ANTXR2
uniprot id: F7AN24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9796:RAB33B
gene id: 9796:RAB33B
uniprot id: F7DEB6
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9796:ARGLU1
gene id: 9796:ARGLU1
uniprot id: F6QJW2
names: Similarity
messages: Belongs to the UPF0430 family.

9796:UTP23
gene id: 9796:UTP23
uniprot id: F6R1A9
names: Subcellular Location Annotation
messages: nucleolus

9796:MAPKAPK3
gene id: 9796:MAPKAPK3
uniprot id: F6UK47
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:CCDC65
gene id: 9796:CCDC65
uniprot id: F6UPA4
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: flagellum axoneme

9796:EARS2
gene id: 9796:EARS2
uniprot id: F7C4S4
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9796:BAG6
gene id: 9796:BAG6
uniprot id: F6ZRP5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: extracellular exosome

9796:ACADVL
gene id: 9796:ACADVL
uniprot id: A0A5F5PZQ2
uniprot id: F6PJ47
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9796:LOC100064329
gene id: 9796:LOC100064329
uniprot id: A0A3Q2L2I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MTG2
gene id: 9796:MTG2
uniprot id: A0A3Q2IL01
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9796:KRT33A
gene id: 9796:KRT33A
uniprot id: F6VDK7
names: Similarity
messages: Belongs to the intermediate filament family.

9796:PIGF
gene id: 9796:PIGF
uniprot id: F6SYH3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:XPO6
gene id: 9796:XPO6
uniprot id: F6Y1V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9796:LOC100072317
gene id: 9796:LOC100072317
uniprot id: F7E3K4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MIF
gene id: 9796:MIF
uniprot id: F6S243
names: Similarity
messages: Belongs to the MIF family.

9796:LOC100068096
gene id: 9796:LOC100068096
uniprot id: F6UQX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:IDUA
gene id: 9796:IDUA
uniprot id: A0A3Q2HYE0
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

9796:OSBPL9
gene id: 9796:OSBPL9
uniprot id: A0A3Q2I5T3
names: Similarity
messages: Belongs to the OSBP family.

9796:SLC16A9
gene id: 9796:SLC16A9
uniprot id: F7C4J8
names: Subcellular Location Annotation
messages: Membrane

9796:CDADC1
gene id: 9796:CDADC1
uniprot id: F6T5C8
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9796:PRKG1
gene id: 9796:PRKG1
uniprot id: A0A3Q2I1N9
uniprot id: F7BM62
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9796:FXYD5
gene id: 9796:FXYD5
uniprot id: A0A3Q2HLX1
names: Similarity
messages: Belongs to the FXYD family.

9796:LOC100060302
gene id: 9796:LOC100060302
uniprot id: F6WXQ1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:NXF1
gene id: 9796:NXF1
uniprot id: F6S7D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9796:CCNH
gene id: 9796:CCNH
uniprot id: F6X7V7
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9796:LOC100068222
gene id: 9796:LOC100068222
uniprot id: A0A3Q2H3M7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:LOC100066329
gene id: 9796:LOC100066329
uniprot id: F6RQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9796:MED6
gene id: 9796:MED6
uniprot id: A0A3Q2I742
uniprot id: F6XBG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9796:RNASE1
gene id: 9796:RNASE1
uniprot id: W0UTH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9796:LOC100073319
gene id: 9796:LOC100073319
uniprot id: F6V5I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:KCNJ8
gene id: 9796:KCNJ8
uniprot id: F6Z3I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9796:TNFRSF14
gene id: 9796:TNFRSF14
uniprot id: Q4G265
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:DCN
gene id: 9796:DCN
uniprot id: O46542
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).
messages: May affect the rate of fibrils formation.
messages: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
messages: extracellular matrix

9796:VWC2
gene id: 9796:VWC2
uniprot id: F7CW74
names: Subcellular Location Annotation
messages: Synapse

9796:TUSC3
gene id: 9796:TUSC3
uniprot id: A0A5F5PG47
uniprot id: F7DTV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:DPAGT1
gene id: 9796:DPAGT1
uniprot id: F7AP50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:ADGRL4
gene id: 9796:ADGRL4
uniprot id: A0A3Q2LPG7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:SIAH1
gene id: 9796:SIAH1
uniprot id: F6WSH9
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9796:MYF5
gene id: 9796:MYF5
uniprot id: F7BTN2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9796:SLC25A34
gene id: 9796:SLC25A34
uniprot id: F7BDE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:LOC100054114
gene id: 9796:LOC100054114
uniprot id: A0A5F5PMR6
names: Similarity
messages: Belongs to the MHC class I family.

9796:CHRM1
gene id: 9796:CHRM1
uniprot id: F6SLG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9796:LOC100050457
gene id: 9796:LOC100050457
uniprot id: A0A3Q2LK10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SERPINB12
gene id: 9796:SERPINB12
uniprot id: F7D7I2
names: Similarity
messages: Belongs to the serpin family.

9796:C22H20orf27
gene id: 9796:C22H20orf27
uniprot id: F6Q0K8
names: Similarity
messages: Belongs to the UPF0687 family.

9796:DEFB119
gene id: 9796:DEFB119
uniprot id: A0A3Q2H9R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9796:LOC100072147
gene id: 9796:LOC100072147
uniprot id: F6XHU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CFB
gene id: 9796:CFB
uniprot id: A0A3Q2IDD2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:MFAP3L
gene id: 9796:MFAP3L
uniprot id: F6THS2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:LOC100067436
gene id: 9796:LOC100067436
uniprot id: A0A5F5PNF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:TOMM40L
gene id: 9796:TOMM40L
uniprot id: F6SFA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9796:CDK10
gene id: 9796:CDK10
uniprot id: A0A3Q2HB58
uniprot id: F6RSU5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:USP3
gene id: 9796:USP3
uniprot id: A5YBM4
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9796:PFDN1
gene id: 9796:PFDN1
uniprot id: A0A3Q2GV13
uniprot id: A0A5F5PPH8
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9796:NRM
gene id: 9796:NRM
uniprot id: F6WIG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9796:NAP1L4
gene id: 9796:NAP1L4
uniprot id: A0A3Q2HV51
uniprot id: F6TPP7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9796:TSHB
gene id: 9796:TSHB
uniprot id: Q28376
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Indispensable for the control of thyroid structure and metabolism.
messages: Secreted

9796:XRCC5
gene id: 9796:XRCC5
uniprot id: F6Z328
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus

9796:IPO4
gene id: 9796:IPO4
uniprot id: F6Q4X9
names: Subcellular Location Annotation
messages: Cytoplasm

9796:DEFB4B
gene id: 9796:DEFB4B
uniprot id: Q865P6
names: Subcellular Location Annotation
messages: Secreted

9796:L3MBTL3
gene id: 9796:L3MBTL3
uniprot id: A0A3Q2LM07
uniprot id: F7BRW8
names: Subcellular Location Annotation
messages: Nucleus

9796:NUMB
gene id: 9796:NUMB
uniprot id: A0A5F5PK46
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9796:PPM1B
gene id: 9796:PPM1B
uniprot id: F6WVS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9796:GJA4
gene id: 9796:GJA4
uniprot id: F7C8J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:ACADSB
gene id: 9796:ACADSB
uniprot id: A0A3Q2HB40
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9796:TNFRSF19
gene id: 9796:TNFRSF19
uniprot id: A0A3Q2HBR8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:NDRG2
gene id: 9796:NDRG2
uniprot id: F6UT17
uniprot id: F6UT73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

9796:LCAT
gene id: 9796:LCAT
uniprot id: F6ZJP9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9796:SNRPA
gene id: 9796:SNRPA
uniprot id: F6ZVU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

9796:LOC100049837
gene id: 9796:LOC100049837
uniprot id: F6TPL7
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9796:HSPB1
gene id: 9796:HSPB1
uniprot id: F7E3Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9796:EDEM2
gene id: 9796:EDEM2
uniprot id: F7BF37
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9796:CNTN1
gene id: 9796:CNTN1
uniprot id: A0A3Q2I6U4
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9796:FOXO4
gene id: 9796:FOXO4
uniprot id: F7DRE4
names: Subcellular Location Annotation
messages: Nucleus

9796:NFYB
gene id: 9796:NFYB
uniprot id: F6XJX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9796:PSMC5
gene id: 9796:PSMC5
uniprot id: A0A3Q2LJS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9796:MYBBP1A
gene id: 9796:MYBBP1A
uniprot id: F6YQZ0
names: Similarity
messages: Belongs to the MYBBP1A family.

9796:NIF3L1
gene id: 9796:NIF3L1
uniprot id: F6UUP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9796:LOC100050473
gene id: 9796:LOC100050473
uniprot id: A0A5F5PPV2
uniprot id: A0A5F5PW08
uniprot id: F7AH72
names: Similarity
messages: Belongs to the MHC class I family.

9796:CYP11A1
gene id: 9796:CYP11A1
uniprot id: O46515
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Interacts with FDX1/adrenodoxin.
messages: Mitochondrion inner membrane

9796:SMIM5
gene id: 9796:SMIM5
uniprot id: F6XTR7
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100072501
gene id: 9796:LOC100072501
uniprot id: A0A3Q2L944
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ROMO1
gene id: 9796:ROMO1
uniprot id: F6RF42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9796:XKR5
gene id: 9796:XKR5
uniprot id: F6RV85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9796:TBRG1
gene id: 9796:TBRG1
uniprot id: F7BZ64
names: Subcellular Location Annotation
messages: Nucleus

9796:RGN
gene id: 9796:RGN
uniprot id: A0A3Q2HW82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

9796:HGD
gene id: 9796:HGD
uniprot id: F6U5B3
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9796:IL36B
gene id: 9796:IL36B
uniprot id: F7CKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9796:IRF6
gene id: 9796:IRF6
uniprot id: A0A3Q2HQB9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9796:ACD
gene id: 9796:ACD
uniprot id: F7CJX5
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9796:LOC100070828
gene id: 9796:LOC100070828
uniprot id: F7A663
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:POSTN
gene id: 9796:POSTN
uniprot id: A0A3Q2H7K2
uniprot id: A0A3Q2HV81
uniprot id: F6Y0G5
names: Subcellular Location Annotation
messages: extracellular matrix

9796:CCT3
gene id: 9796:CCT3
uniprot id: F6V3D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9796:FUCA2
gene id: 9796:FUCA2
uniprot id: A0A3Q2HLY3
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9796:TNP2
gene id: 9796:TNP2
uniprot id: B3LF35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Nucleus
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.

9796:LOC100066863
gene id: 9796:LOC100066863
uniprot id: F6T538
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PTPN6
gene id: 9796:PTPN6
uniprot id: A0A5F5PWB4
uniprot id: F6U9W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9796:SLC10A7
gene id: 9796:SLC10A7
uniprot id: F6RA41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9796:TREX1
gene id: 9796:TREX1
uniprot id: A0A5F5PKY1
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9796:TECR
gene id: 9796:TECR
uniprot id: A0A5F5PGU0
uniprot id: F7A8M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:ELOVL6
gene id: 9796:ELOVL6
uniprot id: A0A3Q2HE08
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9796:LOC106781721
gene id: 9796:LOC106781721
uniprot id: A0A3Q2GS79
names: Subcellular Location Annotation
messages: Membrane

9796:COMTD1
gene id: 9796:COMTD1
uniprot id: F6SJB9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9796:ASPN
gene id: 9796:ASPN
uniprot id: F7E284
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9796:SNUPN
gene id: 9796:SNUPN
uniprot id: F6SNQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

9796:TPK1
gene id: 9796:TPK1
uniprot id: A0A3Q2H2L5
uniprot id: A0A3Q2HD44
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9796:FADS3
gene id: 9796:FADS3
uniprot id: F6PIK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9796:LOC100050904
gene id: 9796:LOC100050904
uniprot id: F7D7T6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9796:UNC119
gene id: 9796:UNC119
uniprot id: A0A3Q2LBC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDE6D/unc-119 family.
messages: spindle

9796:SPIN4
gene id: 9796:SPIN4
uniprot id: F6Z3B6
names: Similarity
messages: Belongs to the SPIN/STSY family.

9796:PDYN
gene id: 9796:PDYN
uniprot id: F7C032
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
messages: Secreted

9796:NUDC
gene id: 9796:NUDC
uniprot id: A0A3Q2HW84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9796:CDC6
gene id: 9796:CDC6
uniprot id: F7B3A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9796:LOC100061569
gene id: 9796:LOC100061569
uniprot id: F6TPA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FCF1
gene id: 9796:FCF1
uniprot id: F6U6H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9796:ADORA1
gene id: 9796:ADORA1
uniprot id: F6RAN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9796:EYA3
gene id: 9796:EYA3
uniprot id: A0A3Q2HT91
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.

9796:GIF
gene id: 9796:GIF
uniprot id: F6TLY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9796:TRAPPC3L
gene id: 9796:TRAPPC3L
uniprot id: F6YFE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9796:YPEL4
gene id: 9796:YPEL4
uniprot id: A0A3Q2I9P5
names: Similarity
messages: Belongs to the yippee family.

9796:GSTZ1
gene id: 9796:GSTZ1
uniprot id: A0A3Q2HHS6
uniprot id: F7AK97
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9796:SERPINB2
gene id: 9796:SERPINB2
uniprot id: F6XHQ3
names: Similarity
messages: Belongs to the serpin family.

9796:CENPL
gene id: 9796:CENPL
uniprot id: F7DPG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9796:WNT7B
gene id: 9796:WNT7B
uniprot id: F6ZTB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9796:LZTFL1
gene id: 9796:LZTFL1
uniprot id: F6PJY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9796:EHHADH
gene id: 9796:EHHADH
uniprot id: F7C8J8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9796:NPR2
gene id: 9796:NPR2
uniprot id: F6TE52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9796:PDE6A
gene id: 9796:PDE6A
uniprot id: F6XG29
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9796:LOC100064221
gene id: 9796:LOC100064221
uniprot id: F6XVR0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:RPS6
gene id: 9796:RPS6
uniprot id: F6V9Q3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9796:DDR2
gene id: 9796:DDR2
uniprot id: A0A3Q2I6H6
names: Subcellular Location Annotation
messages: Membrane

9796:ENKD1
gene id: 9796:ENKD1
uniprot id: F6Y678
names: Subcellular Location Annotation
messages: cilium axoneme

9796:SNRNP200
gene id: 9796:SNRNP200
uniprot id: F7E0H9
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9796:MED1
gene id: 9796:MED1
uniprot id: F6XFN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9796:ARHGEF2
gene id: 9796:ARHGEF2
uniprot id: F7DTZ1
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

9796:BTF3L4
gene id: 9796:BTF3L4
uniprot id: F6WSJ4
names: Similarity
messages: Belongs to the NAC-beta family.

9796:LOC100059532
gene id: 9796:LOC100059532
uniprot id: A0A3Q2HC51
names: Similarity
messages: Belongs to the peptidase A1 family.

9796:RPL30
gene id: 9796:RPL30
uniprot id: F6YBQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9796:CCR6
gene id: 9796:CCR6
uniprot id: F6PP77
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:CYR61
gene id: 9796:CYR61
uniprot id: F6RUJ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:OSGEPL1
gene id: 9796:OSGEPL1
uniprot id: F7A1U7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9796:TMPRSS11D
gene id: 9796:TMPRSS11D
uniprot id: F6QSG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9796:ZFHX3
gene id: 9796:ZFHX3
uniprot id: F6UVC9
names: Subcellular Location Annotation
messages: Nucleus

9796:CAMK1
gene id: 9796:CAMK1
uniprot id: F6YNX6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:PIR
gene id: 9796:PIR
uniprot id: A0A3Q2IDW2
names: Similarity
messages: Belongs to the pirin family.

9796:LOC100057387
gene id: 9796:LOC100057387
uniprot id: F7AD53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PKN2
gene id: 9796:PKN2
uniprot id: F6S2E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9796:LY49F
gene id: 9796:LY49F
uniprot id: Q75XR1
uniprot id: Q75XR2
names: Subcellular Location Annotation
messages: Membrane

9796:SFTPD
gene id: 9796:SFTPD
uniprot id: F7DJE3
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

9796:IL1F10
gene id: 9796:IL1F10
uniprot id: F6X5M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9796:CLUL1
gene id: 9796:CLUL1
uniprot id: F6ZBU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Secreted

9796:TRMT112
gene id: 9796:TRMT112
uniprot id: A0A3Q2LHX2
names: Similarity
messages: Belongs to the TRM112 family.

9796:PDGFC
gene id: 9796:PDGFC
uniprot id: A0A3Q2HV05
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:CLCA1
gene id: 9796:CLCA1
uniprot id: Q2TU62
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CLCR family.
messages: Expressed in mucin-producing cells in the respiratory and intestinal tracts, cutaneous sweat glands, and renal mucous glands (at protein level). Strong overexpression in the airways of horses with recurrent airway obstruction (at protein level).
messages: Glycosylated.
messages: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC (By similarity).
messages: Strongly up-regulated in bronchioles with recurrent airway obstruction (RAO).
messages: The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.
messages: The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
messages: extracellular space

9796:P2RY11
gene id: 9796:P2RY11
uniprot id: F6YAE5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:RAB27B
gene id: 9796:RAB27B
uniprot id: A0A3Q2KTI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9796:CSTF1
gene id: 9796:CSTF1
uniprot id: F6S5J7
names: Subcellular Location Annotation
messages: Nucleus

9796:TYMS
gene id: 9796:TYMS
uniprot id: F6TRC0
names: Similarity
messages: Belongs to the thymidylate synthase family.

9796:PNRC2
gene id: 9796:PNRC2
uniprot id: F6QQ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Nucleus
messages: P-body

9796:LOC100630793
gene id: 9796:LOC100630793
uniprot id: F6PX87
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9796:SPCS2
gene id: 9796:SPCS2
uniprot id: F7C014
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:MDH1
gene id: 9796:MDH1
uniprot id: F7CZS6
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9796:SLC2A5
gene id: 9796:SLC2A5
uniprot id: A0A452GEP2
uniprot id: Q863Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
messages: Membrane
messages: sarcolemma

9796:PRPF3
gene id: 9796:PRPF3
uniprot id: A0A3Q2I021
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9796:EPHA4
gene id: 9796:EPHA4
uniprot id: F7AJ26
names: Subcellular Location Annotation
messages: Membrane

9796:TLR9
gene id: 9796:TLR9
uniprot id: Q2EEY0
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.
messages: Belongs to the Toll-like receptor family.
messages: By mitogen phytohaemagglutinin (PHA) in peripheral blood mononuclear cells (PBMCs) (PubMed:18462806). By lipopolysaccharide (LPS) in cells of the lung septa. This induction is abolished by gadolinium chloride treatment which depletes pulmonary intravascular macrophages (PIMs) (PubMed:19548205). By synthetic class C cytidine-phosphate-guanosine oligodeoxynucleotides (CpG-ODNs) in PBMCs (PubMed:25066759). Synthetic class B CpG-ODN does not induce a significant increase of expression in vitro in neutrophils of foals aged between 2 to 56 days nor in adult horses (PubMed:22197007, PubMed:19819162). Expression level in neutrophils is not significantly changed by virulent strain of R.equi bacterium (PubMed:19819162). Up-regulated by neuropathogenic equine herpesvirus-1 (EHV-1) infection in fully differentiated equine respiratory epithelial cells (ERECs) cultured at the air-fluid interface (AFI) (PubMed:24560592). Up-regulated in gingival tissue in individuals with equine periodontal disease. 16-fold increase in expression at diseased sites of the gums compared to healthy sites of the same animal (PubMed:27270960).
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Expressed in airway epithelium, vascular endothelium and inflammatory cells in blood vessels of the lungs (at protein level). Highly expressed in pulmonary intravascular macrophages (PIMs) and to a lesser extent in alveolar macrophages, neutrophiles, type-II alveolar epithelial cells and bronchial epithelial cells of the lungs (at protein level) (PubMed:19548205). High constitutive intracellular expression in leukocytes including polymorphonuclear leukocytes (PMNs), CD4 and CD8 T cells (at protein level) (PubMed:18462806). Expressed throughout the respiratory tract including larynx, upper, middle and lower trachea, and bronchus in isolated equine respiratory epithelial cells (ERECs) and in fully differentiated ERECs cultured at the air-fluid interface (AFI) (at protein level) (PubMed:21292331). Constitutively expressed in peripheral blood mononuclear cells (PBMCs), lymph nodes and spleen. The level of expression in PBMCs is about 2- to 3-fold higher than that in lymph nodes and spleen. Very low expression in liver, heart, lung, kidney, small intestine, colon and stomach (PubMed:18462806). Low expression in the airway tissue epithelium of the larynx, upper trachea, middle tranchea, lower trachea, bronchus and spleen, and more abundant expression in mesenteric lymph node. Not expressed in fully differentiated bronchus epithelial cells cultured at the AFI for four weeks (PubMed:21292331). Expressed in gingival tissue (PubMed:27270960).
messages: Expression increases with age in neutrophils of an individual foal aged between 2 to 56 days (PubMed:22197007). Expression in neutrophils of a foal at age 1 day, another different foal at age 56 days, and of an adult horse is constitutive at a very low level (PubMed:19819162).
messages: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).
messages: Lysosome
messages: Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (PubMed:25686612). Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (By similarity). Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with SMPDL3B (By similarity).
messages: Nucleus
messages: phagosome

9796:NEUROD2
gene id: 9796:NEUROD2
uniprot id: F6TBQ9
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100063291
gene id: 9796:LOC100063291
uniprot id: A0A5F5PYS1
uniprot id: F7CZN4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9796:CYP2A13
gene id: 9796:CYP2A13
uniprot id: A9UHN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:EPGN
gene id: 9796:EPGN
uniprot id: A0A5F5PZS4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:CLK4
gene id: 9796:CLK4
uniprot id: A0A3Q2GV39
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:ANKRD34A
gene id: 9796:ANKRD34A
uniprot id: F6T9Y5
names: Similarity
messages: Belongs to the ANKRD34 family.

9796:BABAM2
gene id: 9796:BABAM2
uniprot id: F6STU2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9796:SCN2A
gene id: 9796:SCN2A
uniprot id: A0A5K1TVX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9796:GFAP
gene id: 9796:GFAP
uniprot id: A0A5F5PM91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
messages: Interacts with SYNM.

9796:DPYSL5
gene id: 9796:DPYSL5
uniprot id: A0A3Q2GSG2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9796:LOC100072560
gene id: 9796:LOC100072560
uniprot id: F7DVL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PPP2R2A
gene id: 9796:PPP2R2A
uniprot id: F6UHP9
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9796:DNPEP
gene id: 9796:DNPEP
uniprot id: A0A3Q2HPC0
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9796:ZSCAN23
gene id: 9796:ZSCAN23
uniprot id: F6Z334
names: Subcellular Location Annotation
messages: Nucleus

9796:PEX19
gene id: 9796:PEX19
uniprot id: A0A5F5PWG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9796:MHCX1
gene id: 9796:MHCX1
uniprot id: Q30488
names: Similarity
messages: Belongs to the MHC class I family.

9796:C1D
gene id: 9796:C1D
uniprot id: A0A5F5PUP7
uniprot id: K9KCR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9796:NEDD8
gene id: 9796:NEDD8
uniprot id: A0A3Q2HYF4
names: Similarity
messages: Belongs to the ubiquitin family.

9796:RPL6
gene id: 9796:RPL6
uniprot id: K9KFE3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9796:CYP27B1
gene id: 9796:CYP27B1
uniprot id: F6SUV8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9796:LOC100062650
gene id: 9796:LOC100062650
uniprot id: A0A3Q2GY19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

9796:SERPIND1
gene id: 9796:SERPIND1
uniprot id: F7BM31
names: Similarity
messages: Belongs to the serpin family.

9796:LOC100063780
gene id: 9796:LOC100063780
uniprot id: A0A3Q2I893
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NUDT7
gene id: 9796:NUDT7
uniprot id: F6XB22
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9796:KRT71
gene id: 9796:KRT71
uniprot id: F6WMT7
names: Similarity
messages: Belongs to the intermediate filament family.

9796:SLC6A13
gene id: 9796:SLC6A13
uniprot id: A0A5F5PY37
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Membrane

9796:CACNB1
gene id: 9796:CACNB1
uniprot id: A0A3Q2GZ79
uniprot id: A0A3Q2H9X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Membrane
messages: sarcolemma

9796:OVOL1
gene id: 9796:OVOL1
uniprot id: F7AYE5
names: Subcellular Location Annotation
messages: Nucleus

9796:NMD3
gene id: 9796:NMD3
uniprot id: A0A5F5Q146
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9796:EIF6
gene id: 9796:EIF6
uniprot id: F6R0W4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9796:KRT4
gene id: 9796:KRT4
uniprot id: F7D5X8
names: Similarity
messages: Belongs to the intermediate filament family.

9796:ZCCHC4
gene id: 9796:ZCCHC4
uniprot id: A0A3Q2HZB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9796:HARBI1
gene id: 9796:HARBI1
uniprot id: F6Z2K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9796:LOC100072300
gene id: 9796:LOC100072300
uniprot id: F7BTI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:KCNMB1
gene id: 9796:KCNMB1
uniprot id: F6WGD4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9796:SFMBT2
gene id: 9796:SFMBT2
uniprot id: F6R1F6
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100060038
gene id: 9796:LOC100060038
uniprot id: A0A3Q2GZ22
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CCT5
gene id: 9796:CCT5
uniprot id: K9K3Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9796:NTMT1
gene id: 9796:NTMT1
uniprot id: F7CAD0
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9796:TFCP2
gene id: 9796:TFCP2
uniprot id: F6TYZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9796:INSL5
gene id: 9796:INSL5
uniprot id: F6XAA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9796:HADHA
gene id: 9796:HADHA
uniprot id: F6TVY8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9796:SLC24A3
gene id: 9796:SLC24A3
uniprot id: A0A5F5Q4S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9796:MRPS9
gene id: 9796:MRPS9
uniprot id: F7AQB8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9796:UBA2
gene id: 9796:UBA2
uniprot id: F7CZK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

9796:DYRK4
gene id: 9796:DYRK4
uniprot id: F6R5J6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9796:LOC100059658
gene id: 9796:LOC100059658
uniprot id: F6SNY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RAB29
gene id: 9796:RAB29
uniprot id: F7ATF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9796:NR4A1
gene id: 9796:NR4A1
uniprot id: F6XN57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: Cytoplasm
messages: Nucleus

9796:F9
gene id: 9796:F9
uniprot id: F6RFT9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:AP3M2
gene id: 9796:AP3M2
uniprot id: F6Y035
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9796:SCD
gene id: 9796:SCD
uniprot id: F7DN83
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9796:PMP22
gene id: 9796:PMP22
uniprot id: Q6WL85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

9796:RNF121
gene id: 9796:RNF121
uniprot id: F6QT59
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100056789
gene id: 9796:LOC100056789
uniprot id: F6Y7X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ACRBP
gene id: 9796:ACRBP
uniprot id: F6W3D6
names: Subcellular Location Annotation
messages: acrosome

9796:MSH4
gene id: 9796:MSH4
uniprot id: F6PKF0
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9796:PLAA
gene id: 9796:PLAA
uniprot id: F7CG24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9796:HYAL3
gene id: 9796:HYAL3
uniprot id: A0A5F5PVP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Membrane
messages: acrosome

9796:CNOT6
gene id: 9796:CNOT6
uniprot id: F7E2X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9796:NDUFA5
gene id: 9796:NDUFA5
uniprot id: K9KEN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9796:MKS1
gene id: 9796:MKS1
uniprot id: F6RFR4
names: Subcellular Location Annotation
messages: cilium basal body

9796:NUP210L
gene id: 9796:NUP210L
uniprot id: F6SC67
names: Similarity
messages: Belongs to the NUP210 family.

9796:LOC100066846
gene id: 9796:LOC100066846
uniprot id: F6TC71
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FXYD4
gene id: 9796:FXYD4
uniprot id: A0A5F5PKB2
names: Similarity
messages: Belongs to the FXYD family.

9796:LAMP2
gene id: 9796:LAMP2
uniprot id: A0A3Q2H8U6
uniprot id: F6Z9A8
uniprot id: F6ZAT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9796:MTMR6
gene id: 9796:MTMR6
uniprot id: F7CWR6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9796:SDC2
gene id: 9796:SDC2
uniprot id: F6U5M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9796:LOC100629885
gene id: 9796:LOC100629885
uniprot id: A0A5F5PGA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:CWC15
gene id: 9796:CWC15
uniprot id: K9KFW3
names: Similarity
messages: Belongs to the CWC15 family.

9796:MEIS3
gene id: 9796:MEIS3
uniprot id: A0A3Q2HFJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9796:CYP3A97
gene id: 9796:CYP3A97
uniprot id: C9WMG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:LOC100058467
gene id: 9796:LOC100058467
uniprot id: F7A9Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:EBF1
gene id: 9796:EBF1
uniprot id: A0A3Q2HZL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9796:HAMP
gene id: 9796:HAMP
uniprot id: D1KKA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9796:LOC100068732
gene id: 9796:LOC100068732
uniprot id: A0A3Q2GU83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CASQ2
gene id: 9796:CASQ2
uniprot id: F6Z1R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9796:LOC100058373
gene id: 9796:LOC100058373
uniprot id: A0A3Q2HG84
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ARHGDIB
gene id: 9796:ARHGDIB
uniprot id: K9KB03
names: Similarity
messages: Belongs to the Rho GDI family.

9796:LOC100056583
gene id: 9796:LOC100056583
uniprot id: A0A3Q2H7Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:IGF2
gene id: 9796:IGF2
uniprot id: P51459
uniprot id: W8VNM5
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Interacts with MYORG; this interaction is required for IGF2 secretion. Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.
messages: Secreted
messages: The IGF2 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is imprinted, hence silenced.
messages: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).
messages: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate.

9796:S100B
gene id: 9796:S100B
uniprot id: F6RF49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

9796:TARDBP
gene id: 9796:TARDBP
uniprot id: F6WAU6
names: Subcellular Location Annotation
messages: Nucleus

9796:PEX12
gene id: 9796:PEX12
uniprot id: F6UYN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

9796:LOC100630679
gene id: 9796:LOC100630679
uniprot id: F7ABN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DSEL
gene id: 9796:DSEL
uniprot id: F6SII7
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9796:RPL38
gene id: 9796:RPL38
uniprot id: F7AB94
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9796:ANKRD13A
gene id: 9796:ANKRD13A
uniprot id: F7BQL5
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9796:PRUNE1
gene id: 9796:PRUNE1
uniprot id: F7D785
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9796:PKIB
gene id: 9796:PKIB
uniprot id: A0A3Q2HFF9
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9796:LOC100061851
gene id: 9796:LOC100061851
uniprot id: A0A3Q2GVK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PYGM
gene id: 9796:PYGM
uniprot id: B9A9U9
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9796:DMRT1
gene id: 9796:DMRT1
uniprot id: A0A3Q2HC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9796:FIBIN
gene id: 9796:FIBIN
uniprot id: A4UZ23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers (By similarity).
messages: Secreted

9796:MYOZ1
gene id: 9796:MYOZ1
uniprot id: F6YGN8
names: Similarity
messages: Belongs to the myozenin family.

9796:KCNJ11
gene id: 9796:KCNJ11
uniprot id: F6TM38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9796:U2AF2
gene id: 9796:U2AF2
uniprot id: F6RTT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

9796:NMT1
gene id: 9796:NMT1
uniprot id: A0A3Q2I9P9
uniprot id: F7A039
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9796:ECHDC2
gene id: 9796:ECHDC2
uniprot id: A0A5F5PY93
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9796:NOX5
gene id: 9796:NOX5
uniprot id: F6ZC07
names: Subcellular Location Annotation
messages: Membrane

9796:GABRG1
gene id: 9796:GABRG1
uniprot id: F6ZRR6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:DPF3
gene id: 9796:DPF3
uniprot id: F6SJG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the requiem/DPF family.
messages: Nucleus

9796:CORO1C
gene id: 9796:CORO1C
uniprot id: F7DEW5
names: Similarity
messages: Belongs to the WD repeat coronin family.

9796:ATP5MC1
gene id: 9796:ATP5MC1
uniprot id: F7DHX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9796:UFL1
gene id: 9796:UFL1
uniprot id: F7C9V2
uniprot id: K9KFF8
uniprot id: L7MSB8
names: Similarity
messages: Belongs to the UFL1 family.

9796:HAS2
gene id: 9796:HAS2
uniprot id: Q8HZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

9796:STAT3
gene id: 9796:STAT3
uniprot id: A0A3Q2L9H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9796:LOC100062826
gene id: 9796:LOC100062826
uniprot id: A0A3Q2HS38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SFT2D1
gene id: 9796:SFT2D1
uniprot id: F6V6D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9796:LOC100072598
gene id: 9796:LOC100072598
uniprot id: F6X5Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CAV1
gene id: 9796:CAV1
uniprot id: Q2QLB0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: Membrane raft
messages: Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.
messages: caveola

9796:ALB
gene id: 9796:ALB
uniprot id: P35747
names: Allergen
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
messages: Can cause allergic reactions in humans. Binds to IgE.
messages: Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Plasma.
messages: Secreted

9796:PLN
gene id: 9796:PLN
uniprot id: A0A3Q2HEF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

9796:SIM1
gene id: 9796:SIM1
uniprot id: F6X5I8
names: Subcellular Location Annotation
messages: Nucleus

9796:TIMELESS
gene id: 9796:TIMELESS
uniprot id: F6QW70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

9796:ERG
gene id: 9796:ERG
uniprot id: A0A3Q2H4T3
uniprot id: A0A3Q2HMC1
uniprot id: A0A3Q2HQ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:F13A1
gene id: 9796:F13A1
uniprot id: F6UZI2
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9796:FAM162A
gene id: 9796:FAM162A
uniprot id: F7C8W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9796:ACTR1A
gene id: 9796:ACTR1A
uniprot id: F6QXY2
names: Similarity
messages: Belongs to the actin family.

9796:GABRE
gene id: 9796:GABRE
uniprot id: F6XL48
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:TM2D2
gene id: 9796:TM2D2
uniprot id: F6SCH2
names: Subcellular Location Annotation
messages: Membrane

9796:PYGL
gene id: 9796:PYGL
uniprot id: B9A9Y7
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9796:SUGP2
gene id: 9796:SUGP2
uniprot id: F7CNS0
names: Subcellular Location Annotation
messages: Nucleus

9796:KCNV2
gene id: 9796:KCNV2
uniprot id: F6XPZ6
names: Subcellular Location Annotation
messages: Membrane

9796:KIN
gene id: 9796:KIN
uniprot id: F7BIG8
names: Similarity
messages: Belongs to the KIN17 family.

9796:CSPG4
gene id: 9796:CSPG4
uniprot id: F6T201
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:AFP
gene id: 9796:AFP
uniprot id: P49066
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin.
messages: Dimeric and trimeric forms have been found in addition to the monomeric form.
messages: Plasma.
messages: Secreted
messages: Sulfated.

9796:TLCD1
gene id: 9796:TLCD1
uniprot id: F6WSW0
names: Subcellular Location Annotation
messages: Membrane

9796:KCNE3
gene id: 9796:KCNE3
uniprot id: F7E1K1
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9796:PDE2A
gene id: 9796:PDE2A
uniprot id: A0A3Q2IBJ6
uniprot id: F6UGJ6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9796:TUBB
gene id: 9796:TUBB
uniprot id: F6TLD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9796:GMFG
gene id: 9796:GMFG
uniprot id: A0A3Q2LNN5
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9796:LOC100057331
gene id: 9796:LOC100057331
uniprot id: F6QYV5
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9796:SVIL
gene id: 9796:SVIL
uniprot id: A0A3Q2H421
names: Similarity
messages: Belongs to the villin/gelsolin family.

9796:AGBL2
gene id: 9796:AGBL2
uniprot id: A0A3Q2HEA1
uniprot id: F7AV20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9796:LOC102148334
gene id: 9796:LOC102148334
uniprot id: A0A3Q2HUE9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PEX13
gene id: 9796:PEX13
uniprot id: F7DED2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-13 family.
messages: Membrane
messages: Peroxisome membrane

9796:SOD2
gene id: 9796:SOD2
uniprot id: Q9XS41
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
messages: Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.

9796:MED21
gene id: 9796:MED21
uniprot id: F6VIS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9796:RALY
gene id: 9796:RALY
uniprot id: A0A5K1UZZ6
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9796:CMBL
gene id: 9796:CMBL
uniprot id: F6UL42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9796:KATNA1
gene id: 9796:KATNA1
uniprot id: F6PIW9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

9796:NR1H3
gene id: 9796:NR1H3
uniprot id: F6U0L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9796:LOC100066225
gene id: 9796:LOC100066225
uniprot id: F6XNX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GABARAPL2
gene id: 9796:GABARAPL2
uniprot id: F7CYJ4
names: Similarity
messages: Belongs to the ATG8 family.

9796:RPS23
gene id: 9796:RPS23
uniprot id: A0A3Q2GS39
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9796:ABCD3
gene id: 9796:ABCD3
uniprot id: A0A3Q2I8N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9796:PGK2
gene id: 9796:PGK2
uniprot id: Q8MIF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis.
messages: Monomer.

9796:PCSK1
gene id: 9796:PCSK1
uniprot id: F6TCF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9796:FAP
gene id: 9796:FAP
uniprot id: F6RF99
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9796:CRIPT
gene id: 9796:CRIPT
uniprot id: F6RPV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

9796:SKI
gene id: 9796:SKI
uniprot id: Q9TUG2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKI family.
messages: Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes (By similarity).
messages: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling (By similarity).
messages: Nucleus
messages: Ubiquitinated by RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.

9796:IMMP2L
gene id: 9796:IMMP2L
uniprot id: F7DWS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

9796:PSMB10
gene id: 9796:PSMB10
uniprot id: F6SZ35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9796:ZC2HC1C
gene id: 9796:ZC2HC1C
uniprot id: A0A3Q2HRI2
uniprot id: F6QP06
names: Similarity
messages: Belongs to the ZC2HC1 family.

9796:HOXC5
gene id: 9796:HOXC5
uniprot id: F6WR44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9796:LOC100061233
gene id: 9796:LOC100061233
uniprot id: F6T2U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ORC6
gene id: 9796:ORC6
uniprot id: F7CMF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9796:EFNB2
gene id: 9796:EFNB2
uniprot id: B0LDS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:DGKA
gene id: 9796:DGKA
uniprot id: A0A3Q2H790
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9796:LOC100058017
gene id: 9796:LOC100058017
uniprot id: F6QCT3
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100054348
gene id: 9796:LOC100054348
uniprot id: F6VYR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DPY19L4
gene id: 9796:DPY19L4
uniprot id: F6YKF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9796:ASPA
gene id: 9796:ASPA
uniprot id: A0A5F5PM60
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9796:RDH12
gene id: 9796:RDH12
uniprot id: F7BZV2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:TAAR3
gene id: 9796:TAAR3
uniprot id: F7B6M3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:SLC25A38
gene id: 9796:SLC25A38
uniprot id: A0A3Q2H6N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9796:MIOX
gene id: 9796:MIOX
uniprot id: F6VAM9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

9796:PTPN4
gene id: 9796:PTPN4
uniprot id: A0A3Q2HYA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9796:TMEM150A
gene id: 9796:TMEM150A
uniprot id: A0A3Q2L0E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Membrane

9796:FAM3D
gene id: 9796:FAM3D
uniprot id: F7B5J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9796:LOC100070740
gene id: 9796:LOC100070740
uniprot id: F6QIL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TIMP4
gene id: 9796:TIMP4
uniprot id: F7BMM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

9796:LSM5
gene id: 9796:LSM5
uniprot id: F7DLC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9796:BET1
gene id: 9796:BET1
uniprot id: F6X459
names: Subcellular Location Annotation
messages: Membrane

9796:NUF2
gene id: 9796:NUF2
uniprot id: F6WZK8
names: Similarity
messages: Belongs to the NUF2 family.

9796:SF3B6
gene id: 9796:SF3B6
uniprot id: F6T746
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100056712
gene id: 9796:LOC100056712
uniprot id: F6UXT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

9796:LOC100066777
gene id: 9796:LOC100066777
uniprot id: A0A5F5Q1H5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100058417
gene id: 9796:LOC100058417
uniprot id: A0A3Q2H135
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TAAR2
gene id: 9796:TAAR2
uniprot id: F7B625
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:GGA3
gene id: 9796:GGA3
uniprot id: A0A3Q2L844
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9796:NOV
gene id: 9796:NOV
uniprot id: F6TJG2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:MYOG
gene id: 9796:MYOG
uniprot id: A0A090BWQ3
names: Subcellular Location Annotation
messages: Nucleus

9796:SERPINF2
gene id: 9796:SERPINF2
uniprot id: A0A5F5PW18
names: Similarity
messages: Belongs to the serpin family.

9796:ATP7B
gene id: 9796:ATP7B
uniprot id: A0A3Q2KJ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9796:LOC100068820
gene id: 9796:LOC100068820
uniprot id: F7D1Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SLC25A17
gene id: 9796:SLC25A17
uniprot id: A0A5F5Q3X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:LOC100069403
gene id: 9796:LOC100069403
uniprot id: F6YM73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MRPL3
gene id: 9796:MRPL3
uniprot id: F6YS16
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9796:LOC100051073
gene id: 9796:LOC100051073
uniprot id: F7DYB1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9796:FAIM2
gene id: 9796:FAIM2
uniprot id: F6Y5Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9796:CPA1
gene id: 9796:CPA1
uniprot id: A0A3Q2H0M3
names: Similarity
messages: Belongs to the peptidase M14 family.

9796:CA6
gene id: 9796:CA6
uniprot id: B7X749
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide. Its role in saliva is unknown.
messages: Secreted

9796:ELAVL4
gene id: 9796:ELAVL4
uniprot id: A0A3Q2KQJ5
uniprot id: A0A3Q2KRP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9796:PRKCZ
gene id: 9796:PRKCZ
uniprot id: F7DT34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9796:SLC7A3
gene id: 9796:SLC7A3
uniprot id: F6VJA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9796:PIGL
gene id: 9796:PIGL
uniprot id: A0A5F5PJJ4
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9796:PLPP3
gene id: 9796:PLPP3
uniprot id: A0A3Q2H4Q2
uniprot id: F7B3Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9796:SLC26A2
gene id: 9796:SLC26A2
uniprot id: Q65AC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

9796:LOC106783161
gene id: 9796:LOC106783161
uniprot id: F6YWC0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:SAMD8
gene id: 9796:SAMD8
uniprot id: A0A3Q2H204
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9796:IFT122
gene id: 9796:IFT122
uniprot id: F6XD72
names: Subcellular Location Annotation
messages: cilium

9796:HSPB9
gene id: 9796:HSPB9
uniprot id: F6VL99
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

9796:ZFYVE27
gene id: 9796:ZFYVE27
uniprot id: A0A3Q2LP56
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9796:LOC100065075
gene id: 9796:LOC100065075
uniprot id: A0A3Q2L4H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9796:EFHB
gene id: 9796:EFHB
uniprot id: F7DEC2
names: Subcellular Location Annotation
messages: cilium axoneme

9796:LOC100054058
gene id: 9796:LOC100054058
uniprot id: A0A5F5PKH1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:AIP
gene id: 9796:AIP
uniprot id: Q7YRC2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
messages: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

9796:DUOXA2
gene id: 9796:DUOXA2
uniprot id: F7C120
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9796:SNX33
gene id: 9796:SNX33
uniprot id: F6TMS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9796:ACTN3
gene id: 9796:ACTN3
uniprot id: E7D103
names: Similarity
messages: Belongs to the alpha-actinin family.

9796:PYCR1
gene id: 9796:PYCR1
uniprot id: F6Y2T2
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9796:RRM2B
gene id: 9796:RRM2B
uniprot id: F7BM06
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9796:EYA1
gene id: 9796:EYA1
uniprot id: A0A3Q2I578
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9796:BBOF1
gene id: 9796:BBOF1
uniprot id: A0A3Q2IM35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
messages: Belongs to the BBOF1 family.
messages: cilium basal body

9796:GNG11
gene id: 9796:GNG11
uniprot id: F6X563
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9796:CEPT1
gene id: 9796:CEPT1
uniprot id: K9K289
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9796:PSMD4
gene id: 9796:PSMD4
uniprot id: A0A3Q2HYD7
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9796:CAPRIN1
gene id: 9796:CAPRIN1
uniprot id: F7E030
names: Similarity
messages: Belongs to the caprin family.

9796:SEMA4D
gene id: 9796:SEMA4D
uniprot id: F6PIU6
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:DUOX1
gene id: 9796:DUOX1
uniprot id: F6YEX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

9796:LOC102150542
gene id: 9796:LOC102150542
uniprot id: A0A3Q2HLK8
names: Subcellular Location Annotation
messages: Secreted

9796:SAXO1
gene id: 9796:SAXO1
uniprot id: F7BHF5
names: Similarity
messages: Belongs to the FAM154 family.

9796:CENPQ
gene id: 9796:CENPQ
uniprot id: F7BIA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9796:DPH2
gene id: 9796:DPH2
uniprot id: F6QLN2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9796:SCIN
gene id: 9796:SCIN
uniprot id: F6UJD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

9796:RPL13
gene id: 9796:RPL13
uniprot id: F6ZX61
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

9796:CD8A
gene id: 9796:CD8A
uniprot id: F7BJE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:CLCN6
gene id: 9796:CLCN6
uniprot id: F6VRQ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:CNMD
gene id: 9796:CNMD
uniprot id: F7D9D8
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9796:LRP12
gene id: 9796:LRP12
uniprot id: A0A3Q2LTD3
uniprot id: F6YIW6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:GALT
gene id: 9796:GALT
uniprot id: F6Q8J9
uniprot id: F6TXX5
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Binds 1 Fe cation per subunit.

9796:LOC100056023
gene id: 9796:LOC100056023
uniprot id: F7DAP5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RPL21
gene id: 9796:RPL21
uniprot id: F6PTY9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9796:FAM234A
gene id: 9796:FAM234A
uniprot id: A0A3Q2GTB2
uniprot id: F6S1Q2
names: Similarity
messages: Belongs to the FAM234 family.

9796:LOC100052037
gene id: 9796:LOC100052037
uniprot id: F7DIF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MINOS1
gene id: 9796:MINOS1
uniprot id: A0A3Q2L2V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9796:CD3E
gene id: 9796:CD3E
uniprot id: F7CSX8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:CLDN25
gene id: 9796:CLDN25
uniprot id: F7CTQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9796:OASL
gene id: 9796:OASL
uniprot id: Q5MY91
names: Similarity
messages: Belongs to the 2-5A synthase family.

9796:LOC100050835
gene id: 9796:LOC100050835
uniprot id: A0A3Q2HJE7
names: Similarity
messages: Belongs to the cystatin family.

9796:AQP8
gene id: 9796:AQP8
uniprot id: A0A3Q2KRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9796:SKA3
gene id: 9796:SKA3
uniprot id: F7CNU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9796:LOC100068321
gene id: 9796:LOC100068321
uniprot id: F7DLL0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:SCGB1A1
gene id: 9796:SCGB1A1
uniprot id: I1VZ94
uniprot id: I1VZ96
uniprot id: Q8MKG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Antiparallel homodimer; disulfide-linked (By similarity). Interaction with LMBR1L is controversial (By similarity).
messages: Belongs to the secretoglobin family.
messages: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
messages: Club cells (nonciliated cells of the surface epithelium of the pulmonary airways). Expressed in lung, uterus, and prostate.
messages: Secreted

9796:NSUN4
gene id: 9796:NSUN4
uniprot id: F6YMF8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9796:GDPD3
gene id: 9796:GDPD3
uniprot id: A0A3Q2KTV5
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9796:ST6GALNAC4
gene id: 9796:ST6GALNAC4
uniprot id: F6PHY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9796:CCL4
gene id: 9796:CCL4
uniprot id: A0A5F5PT78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9796:MED24
gene id: 9796:MED24
uniprot id: A0A5F5PSS7
uniprot id: F7D947
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9796:LOC100067151
gene id: 9796:LOC100067151
uniprot id: F6VPW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:AK2
gene id: 9796:AK2
uniprot id: F6XJN4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9796:LHB
gene id: 9796:LHB
uniprot id: P08751
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Microheterogeneity at Asn-33. O-glycosylation appears to be responsible for the beta subunit contribution to the difference in LH-receptor binding activity between LSH-B and CG-B.
messages: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
messages: Secreted

9796:ETFRF1
gene id: 9796:ETFRF1
uniprot id: F7AB18
names: Similarity
messages: Belongs to the complex I LYR family.

9796:CRISP1
gene id: 9796:CRISP1
uniprot id: Q8MHX2
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:B3GALT5
gene id: 9796:B3GALT5
uniprot id: F6QMK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:AKR1B1
gene id: 9796:AKR1B1
uniprot id: F7DMQ3
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9796:TFE3
gene id: 9796:TFE3
uniprot id: F6T5E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9796:LOC100054722
gene id: 9796:LOC100054722
uniprot id: F6SB98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DERL1
gene id: 9796:DERL1
uniprot id: F6YNS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9796:GPLD1
gene id: 9796:GPLD1
uniprot id: A0A3Q2LG05
uniprot id: F7A8N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

9796:SNX11
gene id: 9796:SNX11
uniprot id: A0A5F5PNJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9796:GJC1
gene id: 9796:GJC1
uniprot id: F7CQQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:TMEM35A
gene id: 9796:TMEM35A
uniprot id: F6S7R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane
messages: Vesicle

9796:EPHA2
gene id: 9796:EPHA2
uniprot id: F6QAL5
names: Subcellular Location Annotation
messages: Membrane

9796:FGF5
gene id: 9796:FGF5
uniprot id: A0A7U3JWA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted

9796:RRN3
gene id: 9796:RRN3
uniprot id: F6WTE0
names: Similarity
messages: Belongs to the RRN3 family.

9796:CFAP126
gene id: 9796:CFAP126
uniprot id: F7B1U2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9796:SST
gene id: 9796:SST
uniprot id: F6TIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9796:LOC100070856
gene id: 9796:LOC100070856
uniprot id: F7A9K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RBP2
gene id: 9796:RBP2
uniprot id: F7BYU6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9796:CASP1
gene id: 9796:CASP1
uniprot id: Q9TV13
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cell membrane
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NLRP2 and whose function would be the activation of pro-inflammatory caspases. Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis). Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17P/INCA and CARD18. Interacts with SERPINB1; this interaction regulates CASP1 activity.
messages: The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
messages: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.
messages: Ubiquitinated via 'Lys-11'-linked polyubiquitination. Deubiquitinated by USP8.

9796:LOC100053358
gene id: 9796:LOC100053358
uniprot id: A0A3Q2HCD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9796:SMARCA4
gene id: 9796:SMARCA4
uniprot id: F7BQC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9796:GBGT1
gene id: 9796:GBGT1
uniprot id: F6SY78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9796:RPS9
gene id: 9796:RPS9
uniprot id: F7CDJ8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9796:LOC100049890
gene id: 9796:LOC100049890
uniprot id: F6V5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9796:SMIM6
gene id: 9796:SMIM6
uniprot id: A0A5F5PQC5
names: Subcellular Location Annotation
messages: Membrane

9796:PMM1
gene id: 9796:PMM1
uniprot id: F7DK67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9796:KIF2C
gene id: 9796:KIF2C
uniprot id: A0A3Q2I6U5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:CD34
gene id: 9796:CD34
uniprot id: F6S1S0
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100067178
gene id: 9796:LOC100067178
uniprot id: F7D6J7
names: Similarity
messages: Belongs to the mesothelin family.

9796:ADTRP
gene id: 9796:ADTRP
uniprot id: A0A3Q2HFH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9796:RCE1
gene id: 9796:RCE1
uniprot id: A0A3Q2H8L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:DPYSL2
gene id: 9796:DPYSL2
uniprot id: A0A3Q2H363
uniprot id: F7B320
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

9796:LITAF
gene id: 9796:LITAF
uniprot id: Q8MKD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9796:CRP
gene id: 9796:CRP
uniprot id: F6PZG1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9796:PUS3
gene id: 9796:PUS3
uniprot id: F7BZ33
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9796:LOC100054010
gene id: 9796:LOC100054010
uniprot id: F6W778
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RNGTT
gene id: 9796:RNGTT
uniprot id: F6PHA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9796:LOC100073320
gene id: 9796:LOC100073320
uniprot id: F6YLF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100064891
gene id: 9796:LOC100064891
uniprot id: F6R3J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9796:PSMA8
gene id: 9796:PSMA8
uniprot id: F6Q369
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9796:SLC35B4
gene id: 9796:SLC35B4
uniprot id: F6RUW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9796:LOC100063972
gene id: 9796:LOC100063972
uniprot id: A0A3Q2GSF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GATC
gene id: 9796:GATC
uniprot id: F7C1D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9796:DYDC1
gene id: 9796:DYDC1
uniprot id: A0A3Q2LBV0
names: Similarity
messages: Belongs to the dpy-30 family.

9796:BSP1
gene id: 9796:BSP1
uniprot id: Q70GG6
names: Caution
names: Similarity
messages: Belongs to the seminal plasma protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:GPER1
gene id: 9796:GPER1
uniprot id: F7DWI7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:LOC100630823
gene id: 9796:LOC100630823
uniprot id: A0A3Q2IAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:SMDT1
gene id: 9796:SMDT1
uniprot id: F7BCC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9796:MC1R
gene id: 9796:MC1R
uniprot id: P79166
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.
messages: Receptor for MSH (alpha, beta and gamma) and ACTH (By similarity). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity).

9796:TXNL4B
gene id: 9796:TXNL4B
uniprot id: F6S5F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9796:GTF2F2
gene id: 9796:GTF2F2
uniprot id: F6YJV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9796:PLEKHA8
gene id: 9796:PLEKHA8
uniprot id: F7BYB0
names: Subcellular Location Annotation
messages: Membrane
messages: trans-Golgi network membrane

9796:PFDN2
gene id: 9796:PFDN2
uniprot id: F6W739
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9796:EMC3
gene id: 9796:EMC3
uniprot id: F6Z1P7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9796:PXMP4
gene id: 9796:PXMP4
uniprot id: F6SA40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9796:NPY1R
gene id: 9796:NPY1R
uniprot id: F6X0J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:AKR1C1
gene id: 9796:AKR1C1
uniprot id: Q1XAA8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the aldo/keto reductase family.
messages: Cytoplasm
messages: Detected at low levels in preovulatory follicles. Up-regulated in preovulatory follicles during luteinization 12 to 36 hours after stimulation with human chorionic gonadotropin. Up-regulated in granulosa cells 12 to 39 hours after stimulation with human chorionic gonadotropin. Detected at low levels in corpora lutea. Detected at constant low levels in theca interna.
messages: Detected in follicle granulosa cells (at protein level). Detected in heart, lung, liver, kidney, stomach, uterus, testis, skeletal muscle and granulosa cells of the follicle wall.
messages: Monomer.
messages: NADP-dependent oxidoreductase that has 20-alpha-hydroxysteroid dehydrogenase activity.

9796:GALNT15
gene id: 9796:GALNT15
uniprot id: A0A3Q2HH16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9796:FMOD
gene id: 9796:FMOD
uniprot id: A2Q126
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

9796:RAB39B
gene id: 9796:RAB39B
uniprot id: F7E1Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9796:PICK1
gene id: 9796:PICK1
uniprot id: F7DB33
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9796:HTR1B
gene id: 9796:HTR1B
uniprot id: Q0EAB5
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).
messages: Homodimer. Heterodimer with HTR1D (By similarity).
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Palmitoylated.
messages: Phosphorylated.

9796:GPR37
gene id: 9796:GPR37
uniprot id: F6WAE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:SRP72
gene id: 9796:SRP72
uniprot id: F7E174
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

9796:ADAMTS20
gene id: 9796:ADAMTS20
uniprot id: F6PZV0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9796:SLC12A4
gene id: 9796:SLC12A4
uniprot id: A0A3Q2I7X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9796:MAT2B
gene id: 9796:MAT2B
uniprot id: F6WH85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9796:TMBIM4
gene id: 9796:TMBIM4
uniprot id: A0A5F5PH99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9796:ADAMDEC1
gene id: 9796:ADAMDEC1
uniprot id: A0A3Q2HGK3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:PKIA
gene id: 9796:PKIA
uniprot id: A0A3Q2HRB6
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9796:DBT
gene id: 9796:DBT
uniprot id: A0A3Q2I278
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9796:NDUFB8
gene id: 9796:NDUFB8
uniprot id: F6RE30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9796:AGTRAP
gene id: 9796:AGTRAP
uniprot id: A0A3Q2H4U1
names: Subcellular Location Annotation
messages: Membrane

9796:CASP14
gene id: 9796:CASP14
uniprot id: F6RCN7
names: Similarity
messages: Belongs to the peptidase C14A family.

9796:NUP88
gene id: 9796:NUP88
uniprot id: F6PLL3
names: Subcellular Location Annotation
messages: nuclear pore complex

9796:AP2S1
gene id: 9796:AP2S1
uniprot id: F6W1S9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

9796:AKAP3
gene id: 9796:AKAP3
uniprot id: A0A3Q2HIA1
names: Similarity
messages: Belongs to the AKAP110 family.

9796:SPTSSB
gene id: 9796:SPTSSB
uniprot id: F6S733
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:SLC16A13
gene id: 9796:SLC16A13
uniprot id: F7BXB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: Membrane
messages: Vacuole membrane

9796:ACTBL2
gene id: 9796:ACTBL2
uniprot id: F7AHF3
names: Similarity
messages: Belongs to the actin family.

9796:LAMTOR1
gene id: 9796:LAMTOR1
uniprot id: F6XKR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9796:LPIN1
gene id: 9796:LPIN1
uniprot id: A0A3Q2HAE0
names: Similarity
messages: Belongs to the lipin family.

9796:VPS29
gene id: 9796:VPS29
uniprot id: A0A3Q2HL64
uniprot id: F6RYX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9796:NAPA
gene id: 9796:NAPA
uniprot id: F7DE75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9796:TNFRSF11B
gene id: 9796:TNFRSF11B
uniprot id: F7DMU4
names: Caution
names: Function
names: Subunit
messages: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:TMEM41B
gene id: 9796:TMEM41B
uniprot id: F6SEX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9796:SMAD9
gene id: 9796:SMAD9
uniprot id: F6RU71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9796:GPR156
gene id: 9796:GPR156
uniprot id: F6Q9V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9796:EMP2
gene id: 9796:EMP2
uniprot id: F6YYQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9796:LOC100056513
gene id: 9796:LOC100056513
uniprot id: F6TX98
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9796:P2RX6
gene id: 9796:P2RX6
uniprot id: F6RGM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9796:MCEE
gene id: 9796:MCEE
uniprot id: F7ABQ8
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9796:C8H12orf65
gene id: 9796:C8H12orf65
uniprot id: F7CEZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9796:PLG
gene id: 9796:PLG
uniprot id: F6USP9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

9796:FERMT2
gene id: 9796:FERMT2
uniprot id: A0A3Q2HLX7
names: Similarity
messages: Belongs to the kindlin family.

9796:RDH11
gene id: 9796:RDH11
uniprot id: F6VBU9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:ATP5MF
gene id: 9796:ATP5MF
uniprot id: F6TBB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9796:SLCO2B1
gene id: 9796:SLCO2B1
uniprot id: Q30BK7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:GNMT
gene id: 9796:GNMT
uniprot id: F6RBA4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9796:SLIT2
gene id: 9796:SLIT2
uniprot id: F6ZCQ3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:SULT1E1
gene id: 9796:SULT1E1
uniprot id: Q0NXS2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:RPS6KB1
gene id: 9796:RPS6KB1
uniprot id: F7D5V6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9796:LOC100068926
gene id: 9796:LOC100068926
uniprot id: F6RF57
names: Similarity
messages: Belongs to the globin family.

9796:LOC100146890
gene id: 9796:LOC100146890
uniprot id: A0A3Q2GZX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9796:RPL35A
gene id: 9796:RPL35A
uniprot id: F6PTX3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9796:CALHM4
gene id: 9796:CALHM4
uniprot id: F7C5W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9796:LOC100051483
gene id: 9796:LOC100051483
uniprot id: F6RR71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Lysosome

9796:MBOAT1
gene id: 9796:MBOAT1
uniprot id: F7BN22
names: Subcellular Location Annotation
messages: Membrane

9796:KCNK7
gene id: 9796:KCNK7
uniprot id: F6RAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9796:LOC100072007
gene id: 9796:LOC100072007
uniprot id: F6X2F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PLOD3
gene id: 9796:PLOD3
uniprot id: F7B3H1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9796:MTRF1
gene id: 9796:MTRF1
uniprot id: F7C2L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9796:ABLIM3
gene id: 9796:ABLIM3
uniprot id: A0A3Q2HH62
uniprot id: A0A3Q2IAJ7
uniprot id: F6YME5
names: Subcellular Location Annotation
messages: Cytoplasm

9796:MELK
gene id: 9796:MELK
uniprot id: F6T898
uniprot id: F6U4L5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9796:SOAT1
gene id: 9796:SOAT1
uniprot id: A0A3Q2I5P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:HOOK2
gene id: 9796:HOOK2
uniprot id: A0A5F5Q1Y2
uniprot id: F7C4H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9796:LOC100072492
gene id: 9796:LOC100072492
uniprot id: F7ARX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CTC1
gene id: 9796:CTC1
uniprot id: F7CY20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9796:CCL5
gene id: 9796:CCL5
uniprot id: B3VH89
uniprot id: Q8MKD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
messages: Secreted

9796:HS3ST5
gene id: 9796:HS3ST5
uniprot id: F6PP00
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:LOC100069304
gene id: 9796:LOC100069304
uniprot id: F6XVK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FIGNL1
gene id: 9796:FIGNL1
uniprot id: F6X5F5
names: Similarity
messages: Belongs to the AAA ATPase family.

9796:CCK
gene id: 9796:CCK
uniprot id: F7BAG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9796:LOC100052533
gene id: 9796:LOC100052533
uniprot id: F6VJ01
names: Similarity
messages: Belongs to the PRORSD1 family.

9796:ABCD1
gene id: 9796:ABCD1
uniprot id: A0A5F5PK56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9796:LOC100053665
gene id: 9796:LOC100053665
uniprot id: F6UTE8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PHTF2
gene id: 9796:PHTF2
uniprot id: A0A3Q2KRR9
names: Subcellular Location Annotation
messages: Membrane

9796:SLC35E4
gene id: 9796:SLC35E4
uniprot id: F6WCU6
names: Subcellular Location Annotation
messages: Membrane

9796:AOX1
gene id: 9796:AOX1
uniprot id: M1ZMP4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9796:VGLL1
gene id: 9796:VGLL1
uniprot id: F6ZBA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9796:LOC100070786
gene id: 9796:LOC100070786
uniprot id: A0A3Q2GVL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NDP
gene id: 9796:NDP
uniprot id: F6VGL4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:LOC100065063
gene id: 9796:LOC100065063
uniprot id: F6QEU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9796:LOC100056625
gene id: 9796:LOC100056625
uniprot id: A0A3Q2LJZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:BEST1
gene id: 9796:BEST1
uniprot id: F6WEA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9796:HINT1
gene id: 9796:HINT1
uniprot id: K9KBY4
names: Similarity
messages: Belongs to the HINT family.

9796:SLC30A10
gene id: 9796:SLC30A10
uniprot id: F6QZA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9796:LOC100072080
gene id: 9796:LOC100072080
uniprot id: A0A3Q2KR99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:VTI1A
gene id: 9796:VTI1A
uniprot id: A0A3Q2L8R2
uniprot id: F6QEJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9796:NDUFB2
gene id: 9796:NDUFB2
uniprot id: A0A5F5PMU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9796:AQP7
gene id: 9796:AQP7
uniprot id: F7ATW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9796:LOC100071218
gene id: 9796:LOC100071218
uniprot id: F6UGR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:S1PR3
gene id: 9796:S1PR3
uniprot id: F7DUT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9796:CCR5
gene id: 9796:CCR5
uniprot id: A4ZZ54
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:LPL
gene id: 9796:LPL
uniprot id: F6QUF7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9796:IL13
gene id: 9796:IL13
uniprot id: B6C802
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-4/IL-13 family.
messages: Interacts with IL13RA2.
messages: Secreted

9796:LOC100068040
gene id: 9796:LOC100068040
uniprot id: F6UR32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NUDT12
gene id: 9796:NUDT12
uniprot id: F7DVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9796:NMBR
gene id: 9796:NMBR
uniprot id: F6VCY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:LOC100058772
gene id: 9796:LOC100058772
uniprot id: A0A3Q2IAN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GMFB
gene id: 9796:GMFB
uniprot id: F7BW76
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9796:HS2ST1
gene id: 9796:HS2ST1
uniprot id: F6UYS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9796:SLC7A14
gene id: 9796:SLC7A14
uniprot id: F7DMJ2
names: Subcellular Location Annotation
messages: Membrane

9796:SERPINB5
gene id: 9796:SERPINB5
uniprot id: F6YDZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

9796:RPL22
gene id: 9796:RPL22
uniprot id: F6RKM7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9796:ANO10
gene id: 9796:ANO10
uniprot id: A0A3Q2HN93
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:ELOVL4
gene id: 9796:ELOVL4
uniprot id: F6VSU8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9796:ACTL7B
gene id: 9796:ACTL7B
uniprot id: F6RBJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9796:LOC100054332
gene id: 9796:LOC100054332
uniprot id: A0A3Q2IAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:TEC
gene id: 9796:TEC
uniprot id: F6QY61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9796:PTHLH
gene id: 9796:PTHLH
uniprot id: F7CTF0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9796:DRGX
gene id: 9796:DRGX
uniprot id: F6UMR3
names: Subcellular Location Annotation
messages: Nucleus

9796:MUS81
gene id: 9796:MUS81
uniprot id: F7E0I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

9796:OCM2
gene id: 9796:OCM2
uniprot id: F7C7T7
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9796:PPIL3
gene id: 9796:PPIL3
uniprot id: F7D8B0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9796:GJA1
gene id: 9796:GJA1
uniprot id: F6SK35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:APOC2
gene id: 9796:APOC2
uniprot id: F7A1W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
messages: Secreted

9796:TSPAN6
gene id: 9796:TSPAN6
uniprot id: F6T835
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9796:SHC1
gene id: 9796:SHC1
uniprot id: F6ZGT4
names: Subcellular Location Annotation
messages: Cytoplasm

9796:ACTRT2
gene id: 9796:ACTRT2
uniprot id: F7DVW3
names: Similarity
messages: Belongs to the actin family.

9796:ITM2B
gene id: 9796:ITM2B
uniprot id: F6PV25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9796:MRPL42
gene id: 9796:MRPL42
uniprot id: A0A3Q2LMG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9796:YIF1A
gene id: 9796:YIF1A
uniprot id: A8R5L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9796:ELP2
gene id: 9796:ELP2
uniprot id: A0A3Q2H0Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

9796:RSPO3
gene id: 9796:RSPO3
uniprot id: A8C9U2
names: Similarity
messages: Belongs to the R-spondin family.

9796:LOC102150457
gene id: 9796:LOC102150457
uniprot id: F6RHA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

9796:CDK2
gene id: 9796:CDK2
uniprot id: A0A5F5PKM3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:MOG
gene id: 9796:MOG
uniprot id: F6SDU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9796:CDK5R1
gene id: 9796:CDK5R1
uniprot id: F6XY71
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

9796:PRR15
gene id: 9796:PRR15
uniprot id: F6XD11
names: Similarity
messages: Belongs to the PRR15 family.

9796:PIGS
gene id: 9796:PIGS
uniprot id: F7BEJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:FGF7
gene id: 9796:FGF7
uniprot id: F6TLF7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9796:MTFR1
gene id: 9796:MTFR1
uniprot id: A0A3Q2HP72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9796:CD200R1
gene id: 9796:CD200R1
uniprot id: A0A3Q2HUQ6
names: Similarity
messages: Belongs to the CD200R family.

9796:LOC100069113
gene id: 9796:LOC100069113
uniprot id: F7D0X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:KITLG
gene id: 9796:KITLG
uniprot id: A0A5S7PHS1
uniprot id: Q95MD2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form is produced by proteolytic processing of the extracellular domain.
messages: Belongs to the SCF family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity).
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9796:TUBA1A
gene id: 9796:TUBA1A
uniprot id: A0A5F5PZX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9796:MS4A1
gene id: 9796:MS4A1
uniprot id: A0A3Q2L5E5
names: Similarity
messages: Belongs to the MS4A family.

9796:EIF1AD
gene id: 9796:EIF1AD
uniprot id: F6YG42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9796:LOC100071074
gene id: 9796:LOC100071074
uniprot id: F6QB61
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9796:MRGPRF
gene id: 9796:MRGPRF
uniprot id: A4UZ24
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:CAMK2D
gene id: 9796:CAMK2D
uniprot id: A0A3Q2HNM8
uniprot id: A0A3Q2HPA6
uniprot id: A0A3Q2I0K4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9796:MMP7
gene id: 9796:MMP7
uniprot id: F6T7U6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 calcium ions per subunit.

9796:GLS2
gene id: 9796:GLS2
uniprot id: F6YR42
names: Similarity
messages: Belongs to the glutaminase family.

9796:JPT2
gene id: 9796:JPT2
uniprot id: F6ZBI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9796:CCL8
gene id: 9796:CCL8
uniprot id: F6YDU6
uniprot id: Q8MKC8
uniprot id: Q9TTQ2
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9796:TNFSF8
gene id: 9796:TNFSF8
uniprot id: F7D2X3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9796:KRT86
gene id: 9796:KRT86
uniprot id: F6YZV8
names: Similarity
messages: Belongs to the intermediate filament family.

9796:B9D1
gene id: 9796:B9D1
uniprot id: F7BHN1
names: Subcellular Location Annotation
messages: cilium basal body

9796:FBXO25
gene id: 9796:FBXO25
uniprot id: A0A5F5PIP0
uniprot id: F6U5W3
names: Subcellular Location Annotation
messages: Nucleus

9796:FURIN
gene id: 9796:FURIN
uniprot id: F7DHR9
names: Similarity
messages: Belongs to the peptidase S8 family.

9796:WDYHV1
gene id: 9796:WDYHV1
uniprot id: A0A3Q2I1U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9796:SFXN2
gene id: 9796:SFXN2
uniprot id: F6WRD2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9796:IL36RN
gene id: 9796:IL36RN
uniprot id: F7C2V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9796:PLPPR4
gene id: 9796:PLPPR4
uniprot id: F7B3C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9796:WARS2
gene id: 9796:WARS2
uniprot id: K9K3B1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9796:SLC5A1
gene id: 9796:SLC5A1
uniprot id: Q9BDF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9796:NPY
gene id: 9796:NPY
uniprot id: A0A5F5PZX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9796:ZC3H12B
gene id: 9796:ZC3H12B
uniprot id: F6TY57
names: Similarity
messages: Belongs to the ZC3H12 family.

9796:RPS27A
gene id: 9796:RPS27A
uniprot id: F7AUY9
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9796:CALHM5
gene id: 9796:CALHM5
uniprot id: F6U6K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9796:DNTT
gene id: 9796:DNTT
uniprot id: F6V4S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

9796:LGI4
gene id: 9796:LGI4
uniprot id: F6WFY6
names: Subcellular Location Annotation
messages: Secreted

9796:MOGAT1
gene id: 9796:MOGAT1
uniprot id: F7B245
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:ZHX3
gene id: 9796:ZHX3
uniprot id: F6XDA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9796:OLFM3
gene id: 9796:OLFM3
uniprot id: A0A5F5PTA2
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9796:GEM
gene id: 9796:GEM
uniprot id: F7A697
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9796:LOC100065103
gene id: 9796:LOC100065103
uniprot id: A0A3Q2LNJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9796:MMP3
gene id: 9796:MMP3
uniprot id: Q28397
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 4 Ca(2+) ions per subunit.
messages: Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Acts also intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. In addition, plays a role in immune response and possesses antiviral activity against various viruses. Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

9796:VSTM5
gene id: 9796:VSTM5
uniprot id: F7BI72
names: Subcellular Location Annotation
messages: Membrane

9796:FAM20B
gene id: 9796:FAM20B
uniprot id: F7DK06
names: Similarity
messages: Belongs to the FAM20 family.

9796:FSCN3
gene id: 9796:FSCN3
uniprot id: F6S5W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9796:FGD2
gene id: 9796:FGD2
uniprot id: A0A3Q2GRP7
uniprot id: A0A3Q2KLD1
names: Subcellular Location Annotation
messages: cytoskeleton

9796:ETNPPL
gene id: 9796:ETNPPL
uniprot id: F6ZEX8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9796:FMN1
gene id: 9796:FMN1
uniprot id: A0A5F5PP37
names: Similarity
messages: Belongs to the formin homology family. Cappuccino subfamily.

9796:HSD17B13
gene id: 9796:HSD17B13
uniprot id: F6QVI0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:RPRD1A
gene id: 9796:RPRD1A
uniprot id: A0A3Q2H9R9
uniprot id: A0A3Q2HJA0
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9796:LOC100052045
gene id: 9796:LOC100052045
uniprot id: F7E419
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9796:GRM2
gene id: 9796:GRM2
uniprot id: F6YQJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9796:DEGS2
gene id: 9796:DEGS2
uniprot id: F6VWM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:PRKAR1A
gene id: 9796:PRKAR1A
uniprot id: F7DX98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9796:POLG2
gene id: 9796:POLG2
uniprot id: F6T4Z0
names: Subcellular Location Annotation
messages: Mitochondrion

9796:CACNB3
gene id: 9796:CACNB3
uniprot id: A0A3Q2HUK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9796:GPR35
gene id: 9796:GPR35
uniprot id: F6ZR41
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:NIT1
gene id: 9796:NIT1
uniprot id: A0A3Q2I737
uniprot id: F7CY80
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9796:GGNBP2
gene id: 9796:GGNBP2
uniprot id: A0A3Q2HGL4
names: Function
messages: May be involved in spermatogenesis.

9796:PRPF31
gene id: 9796:PRPF31
uniprot id: F6T5B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

9796:DVL2
gene id: 9796:DVL2
uniprot id: F6PSL5
names: Similarity
messages: Belongs to the DSH family.

9796:ARSG
gene id: 9796:ARSG
uniprot id: F6UND9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9796:CPSF4
gene id: 9796:CPSF4
uniprot id: F7DCT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9796:GSDMB
gene id: 9796:GSDMB
uniprot id: F6XW93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9796:TFRC
gene id: 9796:TFRC
uniprot id: Q2V905
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
messages: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Interacts with SH3BP4 (By similarity). Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity).
messages: Melanosome
messages: Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (By similarity). Stearoylation does not affect iron uptake (By similarity).

9796:KIF9
gene id: 9796:KIF9
uniprot id: F6Q4D6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:ELOA
gene id: 9796:ELOA
uniprot id: F7CTT6
names: Subcellular Location Annotation
messages: Nucleus

9796:KEF40 p06
gene id: 9796:KEF40_p06
uniprot id: A5JYA8
uniprot id: P48654
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9796:TLR2
gene id: 9796:TLR2
uniprot id: Q6T752
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
messages: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
messages: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).
messages: Membrane
messages: Membrane raft
messages: The ATG16L1-binding motif mediates interaction with ATG16L1.
messages: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
messages: phagosome membrane

9796:ACTRT3
gene id: 9796:ACTRT3
uniprot id: A0A3Q2HJJ5
names: Similarity
messages: Belongs to the actin family.

9796:GPR50
gene id: 9796:GPR50
uniprot id: F6YWA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:ATP5MC3
gene id: 9796:ATP5MC3
uniprot id: F6TXS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9796:RPS24
gene id: 9796:RPS24
uniprot id: A0A5F5PYV3
uniprot id: F6Z3G3
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9796:ACTB
gene id: 9796:ACTB
uniprot id: P60708
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
messages: Belongs to the actin family.
messages: ISGylated.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-73 by SETD3 (By similarity). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).
messages: Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM (By similarity). Interacts with TBC1D21. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes. Interacts with FAM107A (By similarity).
messages: cytoskeleton

9796:LOC100063866
gene id: 9796:LOC100063866
uniprot id: A0A3Q2IAW4
uniprot id: A0A3Q2IB58
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9796:CACNB2
gene id: 9796:CACNB2
uniprot id: A0A5F5PT19
uniprot id: F7CPA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
messages: sarcolemma

9796:CCL3
gene id: 9796:CCL3
uniprot id: B1AB88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9796:PUS10
gene id: 9796:PUS10
uniprot id: F7A253
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

9796:ENY2
gene id: 9796:ENY2
uniprot id: F7CV71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9796:LOC100059700
gene id: 9796:LOC100059700
uniprot id: F6UU57
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:ACTG2
gene id: 9796:ACTG2
uniprot id: A0A3Q2HBP5
names: Similarity
messages: Belongs to the actin family.

9796:SNX10
gene id: 9796:SNX10
uniprot id: A0A3Q2IC52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9796:ALOX12B
gene id: 9796:ALOX12B
uniprot id: F6PXL3
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:CDC37L1
gene id: 9796:CDC37L1
uniprot id: F7DU75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9796:S100A4
gene id: 9796:S100A4
uniprot id: F6UF75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9796:XPO7
gene id: 9796:XPO7
uniprot id: F7C3B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9796:SSR2
gene id: 9796:SSR2
uniprot id: F7BIU0
uniprot id: K9K263
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9796:LOC100052837
gene id: 9796:LOC100052837
uniprot id: F7B9F5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:ASNA1
gene id: 9796:ASNA1
uniprot id: F7BUE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9796:LOC100061281
gene id: 9796:LOC100061281
uniprot id: F6VAH3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:ACTR2
gene id: 9796:ACTR2
uniprot id: A0A3Q2HMR5
uniprot id: F6WM79
names: Similarity
messages: Belongs to the actin family.

9796:DEDD2
gene id: 9796:DEDD2
uniprot id: A0A3Q2IDD5
names: Subcellular Location Annotation
messages: nucleolus

9796:LOC100055776
gene id: 9796:LOC100055776
uniprot id: F7B0I8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RFTN2
gene id: 9796:RFTN2
uniprot id: F6WFU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9796:ECATH-3
gene id: 9796:ECATH-3
uniprot id: O62842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9796:TSFM
gene id: 9796:TSFM
uniprot id: F6SMB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

9796:LOC100066469
gene id: 9796:LOC100066469
uniprot id: F7DI27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ARG1
gene id: 9796:ARG1
uniprot id: F7CJ82
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9796:TBPL1
gene id: 9796:TBPL1
uniprot id: F7DF13
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9796:LOC100068769
gene id: 9796:LOC100068769
uniprot id: A0A3Q2IBD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HSPA13
gene id: 9796:HSPA13
uniprot id: F6Z4B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

9796:SLC35F6
gene id: 9796:SLC35F6
uniprot id: F6SPB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9796:NCBP3
gene id: 9796:NCBP3
uniprot id: F6VW27
names: Similarity
messages: Belongs to the NCBP3 family.

9796:GAPDH
gene id: 9796:GAPDH
uniprot id: F6YV40
uniprot id: Q9TUX5
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9796:HSCB
gene id: 9796:HSCB
uniprot id: A0A3Q2HTA2
uniprot id: F6WGR2
names: Similarity
messages: Belongs to the HscB family.

9796:LOC106782245
gene id: 9796:LOC106782245
uniprot id: A0A3Q2HEM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:OLFML2B
gene id: 9796:OLFML2B
uniprot id: F6Z1C0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:ALDH16A1
gene id: 9796:ALDH16A1
uniprot id: F7C3N9
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Interacts with SPG21.

9796:G6PC
gene id: 9796:G6PC
uniprot id: F7CY60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9796:FAM213A
gene id: 9796:FAM213A
uniprot id: F6WLE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

9796:FN3K
gene id: 9796:FN3K
uniprot id: F6UZE0
names: Similarity
messages: Belongs to the fructosamine kinase family.

9796:PCK1
gene id: 9796:PCK1
uniprot id: F6ZRM2
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9796:COQ3
gene id: 9796:COQ3
uniprot id: F6Z4C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9796:DZIP3
gene id: 9796:DZIP3
uniprot id: F7DNC4
names: Subcellular Location Annotation
messages: Cytoplasm

9796:SHTN1
gene id: 9796:SHTN1
uniprot id: A0A3Q2HNI7
uniprot id: A0A5F5PMP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9796:TCTEX1D1
gene id: 9796:TCTEX1D1
uniprot id: F7DX03
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9796:GAL3ST3
gene id: 9796:GAL3ST3
uniprot id: F6WHJ6
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9796:SLC25A11
gene id: 9796:SLC25A11
uniprot id: F7A7B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:PRKACA
gene id: 9796:PRKACA
uniprot id: A0A3Q2L0R7
uniprot id: F7AI06
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9796:RNPS1
gene id: 9796:RNPS1
uniprot id: F6U567
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus speckle

9796:ARL5A
gene id: 9796:ARL5A
uniprot id: F7CEL2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9796:TTLL9
gene id: 9796:TTLL9
uniprot id: F7B688
names: Similarity
messages: Belongs to the tubulin--tyrosine ligase family.

9796:SLC31A2
gene id: 9796:SLC31A2
uniprot id: A0A3Q2HRL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9796:CEBPE
gene id: 9796:CEBPE
uniprot id: F6RU48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9796:CPT1A
gene id: 9796:CPT1A
uniprot id: Q68Y62
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A conformation change in the N-terminal region spanning the first 42 residues plays an important role in the regulation of enzyme activity by malonyl-CoA.
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (By similarity). Plays an important role in hepatic triglyceride metabolism (By similarity).
messages: Homohexamer and homotrimer (By similarity). Identified in a complex that contains at least CPT1A, ACSL1 and VDAC1 (By similarity). Also identified in complexes with ACSL1 and VDAC2 and VDAC3 (By similarity).
messages: Mitochondrion outer membrane

9796:ELP3
gene id: 9796:ELP3
uniprot id: F7DT07
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9796:APAF1
gene id: 9796:APAF1
uniprot id: F6R504
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

9796:CNTNAP5
gene id: 9796:CNTNAP5
uniprot id: F6QSR8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.
messages: Membrane

9796:KIAA1324
gene id: 9796:KIAA1324
uniprot id: F6TRZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9796:ASPM
gene id: 9796:ASPM
uniprot id: F6Y6R3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9796:ENPP3
gene id: 9796:ENPP3
uniprot id: F7CLE3
names: Subcellular Location Annotation
messages: Secreted

9796:TMLHE
gene id: 9796:TMLHE
uniprot id: F6SRV8
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

9796:CERS6
gene id: 9796:CERS6
uniprot id: A0A3Q2H6T3
uniprot id: A0A3Q2H814
uniprot id: F7BVU2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9796:MST1
gene id: 9796:MST1
uniprot id: F7BK76
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:LOC100072330
gene id: 9796:LOC100072330
uniprot id: F7E0T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:C18H2orf76
gene id: 9796:C18H2orf76
uniprot id: F6W5M9
names: Similarity
messages: Belongs to the UPF0538 family.

9796:PIK3CA
gene id: 9796:PIK3CA
uniprot id: F6VFI8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9796:SSTR1
gene id: 9796:SSTR1
uniprot id: F6QWD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:ACE2
gene id: 9796:ACE2
uniprot id: F6V9L3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9796:PRPF4B
gene id: 9796:PRPF4B
uniprot id: F7DW09
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

9796:SLC37A2
gene id: 9796:SLC37A2
uniprot id: A0A5F5PIF9
uniprot id: F6R0U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9796:AVPR2
gene id: 9796:AVPR2
uniprot id: F6UX08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Membrane

9796:FBP2
gene id: 9796:FBP2
uniprot id: F6YTD3
names: Similarity
messages: Belongs to the FBPase class 1 family.

9796:NMI
gene id: 9796:NMI
uniprot id: F7DJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9796:ARL8B
gene id: 9796:ARL8B
uniprot id: F6RIG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: spindle

9796:DLGAP1
gene id: 9796:DLGAP1
uniprot id: A0A3Q2IDG6
uniprot id: F6ZYI4
names: Similarity
messages: Belongs to the SAPAP family.

9796:ASZ1
gene id: 9796:ASZ1
uniprot id: Q2QLA4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

9796:ERBB4
gene id: 9796:ERBB4
uniprot id: F6T440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9796:FXYD1
gene id: 9796:FXYD1
uniprot id: F7C0I1
names: Similarity
messages: Belongs to the FXYD family.

9796:NIPA2
gene id: 9796:NIPA2
uniprot id: F7A8V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9796:LOC100049926
gene id: 9796:LOC100049926
uniprot id: A0A3Q2HU76
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:FSHB
gene id: 9796:FSHB
uniprot id: K9NVU5
uniprot id: P01226
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.
messages: Secreted
messages: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.

9796:KIF27
gene id: 9796:KIF27
uniprot id: F6S597
uniprot id: F6S5U9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:LOC100055965
gene id: 9796:LOC100055965
uniprot id: F7DQR5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9796:AQP10
gene id: 9796:AQP10
uniprot id: A0A3Q2HMG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9796:LOC100065548
gene id: 9796:LOC100065548
uniprot id: F6VZE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:STARD9
gene id: 9796:STARD9
uniprot id: A0A3Q2H095
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:RNF20
gene id: 9796:RNF20
uniprot id: A0A3Q2GUF4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9796:TAF5L
gene id: 9796:TAF5L
uniprot id: F6QHX1
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9796:PHOSPHO1
gene id: 9796:PHOSPHO1
uniprot id: A0A3Q2HA82
uniprot id: F6XQJ9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9796:SELL
gene id: 9796:SELL
uniprot id: F7E0Z9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:HIGD1B
gene id: 9796:HIGD1B
uniprot id: F6VHZ9
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9796:MRPL13
gene id: 9796:MRPL13
uniprot id: F6U4D0
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9796:MRPL58
gene id: 9796:MRPL58
uniprot id: F7AGV1
names: Subcellular Location Annotation
messages: Mitochondrion

9796:ESR2
gene id: 9796:ESR2
uniprot id: F6S2G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9796:MARCO
gene id: 9796:MARCO
uniprot id: A0A3Q2I6Q7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:FABP3
gene id: 9796:FABP3
uniprot id: F6Q6W4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9796:MYBL1
gene id: 9796:MYBL1
uniprot id: F6TNL2
names: Subcellular Location Annotation
messages: Nucleus

9796:LRRC14
gene id: 9796:LRRC14
uniprot id: F6ZBU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRAME family. LRRC14 subfamily.
messages: Cytoplasm

9796:KIF16B
gene id: 9796:KIF16B
uniprot id: F6UWF5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:TSPAN8
gene id: 9796:TSPAN8
uniprot id: H9H043
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9796:GPR18
gene id: 9796:GPR18
uniprot id: F6VVV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9796:PHOSPHO2
gene id: 9796:PHOSPHO2
uniprot id: A0A3Q2L3K4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9796:RPS19
gene id: 9796:RPS19
uniprot id: A0A5F5PLG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

9796:FXYD6
gene id: 9796:FXYD6
uniprot id: A0A5F5Q235
names: Similarity
messages: Belongs to the FXYD family.

9796:RTCB
gene id: 9796:RTCB
uniprot id: F6WLX9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9796:LOC100072566
gene id: 9796:LOC100072566
uniprot id: F6WGB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MCM8
gene id: 9796:MCM8
uniprot id: A0A3Q2H7J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9796:ATP6V0A4
gene id: 9796:ATP6V0A4
uniprot id: F6QG54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9796:TYW3
gene id: 9796:TYW3
uniprot id: F6WF67
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9796:LOC100067738
gene id: 9796:LOC100067738
uniprot id: F6W978
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ELL3
gene id: 9796:ELL3
uniprot id: F6VY32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9796:MINDY4
gene id: 9796:MINDY4
uniprot id: F6QHK3
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9796:MAU2
gene id: 9796:MAU2
uniprot id: F6T2G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9796:ADIPOR2
gene id: 9796:ADIPOR2
uniprot id: F6T267
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9796:EXOC6B
gene id: 9796:EXOC6B
uniprot id: A0A3Q2I1K2
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9796:LYZL6
gene id: 9796:LYZL6
uniprot id: F6YHQ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9796:LOC100629331
gene id: 9796:LOC100629331
uniprot id: A0A3Q2ICP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9796:LOC100067990
gene id: 9796:LOC100067990
uniprot id: F6ZR94
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9796:POU2F1
gene id: 9796:POU2F1
uniprot id: A0A3Q2IE04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9796:ZSCAN29
gene id: 9796:ZSCAN29
uniprot id: F6SCD9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9796:SORD
gene id: 9796:SORD
uniprot id: F7A1C3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 1 or 2 Zn(2+) ions per subunit.
messages: Homotetramer.
messages: Mitochondrion membrane
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
messages: flagellum

9796:CLCN4
gene id: 9796:CLCN4
uniprot id: A0A3Q2I449
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9796:LOC100065423
gene id: 9796:LOC100065423
uniprot id: F6WEF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100054063
gene id: 9796:LOC100054063
uniprot id: A0A3Q2KPN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TM6SF2
gene id: 9796:TM6SF2
uniprot id: F6UJB8
names: Subcellular Location Annotation
messages: Membrane

9796:CDS2
gene id: 9796:CDS2
uniprot id: F6SRD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9796:TNFSF12
gene id: 9796:TNFSF12
uniprot id: A0A0U5CJN1
uniprot id: A0A3Q2HDL6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9796:UCK1
gene id: 9796:UCK1
uniprot id: F6W593
names: Similarity
messages: Belongs to the uridine kinase family.

9796:TNFSF15
gene id: 9796:TNFSF15
uniprot id: A0A0U5J7L1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9796:PGAP3
gene id: 9796:PGAP3
uniprot id: F6YBP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Membrane

9796:EIF1
gene id: 9796:EIF1
uniprot id: A0A3Q2LKP7
names: Similarity
messages: Belongs to the SUI1 family.

9796:FABP1
gene id: 9796:FABP1
uniprot id: F6UL59
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9796:ZNF687
gene id: 9796:ZNF687
uniprot id: F7B2F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9796:NCOA2
gene id: 9796:NCOA2
uniprot id: A0A3Q2ICS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9796:POMT2
gene id: 9796:POMT2
uniprot id: F6ZEH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9796:SLC16A1
gene id: 9796:SLC16A1
uniprot id: Q6SJP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9796:OGT
gene id: 9796:OGT
uniprot id: F6Z4I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9796:GPR65
gene id: 9796:GPR65
uniprot id: F6V2Q6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:TIPIN
gene id: 9796:TIPIN
uniprot id: F6SQ20
uniprot id: L7MRU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9796:GCNT1
gene id: 9796:GCNT1
uniprot id: A8CWP2
uniprot id: F7BT86
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9796:PLA2G4B
gene id: 9796:PLA2G4B
uniprot id: F6T946
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9796:TACR1
gene id: 9796:TACR1
uniprot id: F6Z7L5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9796:SLC4A8
gene id: 9796:SLC4A8
uniprot id: A0A3Q2LLP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9796:KIF3C
gene id: 9796:KIF3C
uniprot id: F6UYR5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:DOCK2
gene id: 9796:DOCK2
uniprot id: F6R9H6
names: Similarity
messages: Belongs to the DOCK family.

9796:LOC100054282
gene id: 9796:LOC100054282
uniprot id: F6XKX6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

9796:LOC100057505
gene id: 9796:LOC100057505
uniprot id: F6WFZ5
names: Similarity
messages: Belongs to the serpin family.

9796:KCND2
gene id: 9796:KCND2
uniprot id: F6U3G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9796:BTC
gene id: 9796:BTC
uniprot id: F7B8P3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:LOC100069179
gene id: 9796:LOC100069179
uniprot id: F6XLY5
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9796:CNPY1
gene id: 9796:CNPY1
uniprot id: F6YKG5
names: Similarity
messages: Belongs to the canopy family.

9796:ZPR1
gene id: 9796:ZPR1
uniprot id: F7AQ99
names: Similarity
messages: Belongs to the ZPR1 family.

9796:LOC100066339
gene id: 9796:LOC100066339
uniprot id: A0A5F5PG81
names: Similarity
messages: Belongs to the Luc7 family.

9796:MAB21L1
gene id: 9796:MAB21L1
uniprot id: F6Q0X3
names: Similarity
messages: Belongs to the mab-21 family.

9796:PIM1
gene id: 9796:PIM1
uniprot id: F6UWX4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9796:DUSP13
gene id: 9796:DUSP13
uniprot id: A0A3Q2HCD7
uniprot id: F7CNS5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9796:KRT79
gene id: 9796:KRT79
uniprot id: F6XWG3
names: Similarity
messages: Belongs to the intermediate filament family.

9796:MRPL16
gene id: 9796:MRPL16
uniprot id: F7D2V5
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9796:VOPP1
gene id: 9796:VOPP1
uniprot id: A0A3Q2HBS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
messages: Membrane

9796:FLVCR1
gene id: 9796:FLVCR1
uniprot id: F6PHV8
names: Subcellular Location Annotation
messages: Membrane

9796:LOC106780853
gene id: 9796:LOC106780853
uniprot id: A0A3Q2L2N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SGTB
gene id: 9796:SGTB
uniprot id: F6YHI3
names: Similarity
messages: Belongs to the SGT family.

9796:LOC100065521
gene id: 9796:LOC100065521
uniprot id: A0A3Q2I7D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MB
gene id: 9796:MB
uniprot id: P68082
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9796:NDUFB9
gene id: 9796:NDUFB9
uniprot id: F7CIH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9796:SHQ1
gene id: 9796:SHQ1
uniprot id: F6TT60
names: Similarity
messages: Belongs to the SHQ1 family.

9796:LOC100064378
gene id: 9796:LOC100064378
uniprot id: A0A5F5PW36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Rough endoplasmic reticulum

9796:LOC100054443
gene id: 9796:LOC100054443
uniprot id: F6TWT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:KRTAP24-1
gene id: 9796:KRTAP24-1
uniprot id: F6UYV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KRTAP type 3 family.
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9796:C14H5orf30
gene id: 9796:C14H5orf30
uniprot id: A0A3Q2GZR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9796:SLC30A6
gene id: 9796:SLC30A6
uniprot id: F6XVT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9796:MTERF2
gene id: 9796:MTERF2
uniprot id: K9K4F8
names: Similarity
messages: Belongs to the mTERF family.

9796:SLC25A40
gene id: 9796:SLC25A40
uniprot id: F6Z1G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9796:MMP1
gene id: 9796:MMP1
uniprot id: Q9XSZ5
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 4 Ca(2+) ions per subunit.
messages: Can be activated without removal of the activation peptide.
messages: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: Tyrosine phosphorylated in platelets by PKDCC/VLK.
messages: extracellular matrix

9796:LOC100055688
gene id: 9796:LOC100055688
uniprot id: F6XXL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TMTC4
gene id: 9796:TMTC4
uniprot id: F7D9L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9796:AFM
gene id: 9796:AFM
uniprot id: F7B3I5
names: Subcellular Location Annotation
messages: Secreted

9796:WDFY2
gene id: 9796:WDFY2
uniprot id: F7DXY5
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9796:NNT
gene id: 9796:NNT
uniprot id: F6YLK4
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9796:C3AR1
gene id: 9796:C3AR1
uniprot id: F6YIS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9796:TBX15
gene id: 9796:TBX15
uniprot id: A0A3Q2GZR6
uniprot id: F6VPR5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9796:HPCAL4
gene id: 9796:HPCAL4
uniprot id: F7AZV3
names: Function
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

9796:ARSA
gene id: 9796:ARSA
uniprot id: F7CJW5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9796:LSM4
gene id: 9796:LSM4
uniprot id: A0A5F5PNA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9796:FAM133A
gene id: 9796:FAM133A
uniprot id: A0A3Q2KNL6
names: Similarity
messages: Belongs to the FAM133 family.

9796:RAB3GAP1
gene id: 9796:RAB3GAP1
uniprot id: A0A3Q2I526
uniprot id: F6QUK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm

9796:CRLS1
gene id: 9796:CRLS1
uniprot id: A0A5F5PNU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9796:HNRNPK
gene id: 9796:HNRNPK
uniprot id: F6Q4Q1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9796:MRRF
gene id: 9796:MRRF
uniprot id: A0A5F5PPV3
uniprot id: K9K2A5
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9796:PTP4A2
gene id: 9796:PTP4A2
uniprot id: K9K410
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9796:DOCK4
gene id: 9796:DOCK4
uniprot id: A0A3Q2GUE6
names: Similarity
messages: Belongs to the DOCK family.

9796:LOC100061889
gene id: 9796:LOC100061889
uniprot id: A0A3Q2KXJ9
names: Similarity
messages: Belongs to the PRAME family.

9796:CD38
gene id: 9796:CD38
uniprot id: F6T4L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Membrane

9796:USP9X
gene id: 9796:USP9X
uniprot id: F7CE06
names: Similarity
messages: Belongs to the peptidase C19 family.

9796:LOC106781472
gene id: 9796:LOC106781472
uniprot id: F6S8B6
names: Subcellular Location Annotation
messages: Secreted

9796:AATF
gene id: 9796:AATF
uniprot id: F6URV4
names: Similarity
messages: Belongs to the AATF family.

9796:HAL
gene id: 9796:HAL
uniprot id: A0A3Q2GU92
uniprot id: F6TGW2
names: Similarity
messages: Belongs to the PAL/histidase family.

9796:TARBP2
gene id: 9796:TARBP2
uniprot id: F7BEN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9796:SIN3B
gene id: 9796:SIN3B
uniprot id: A0A3Q2GV33
names: Subcellular Location Annotation
messages: Nucleus

9796:ACADM
gene id: 9796:ACADM
uniprot id: A0A3Q2H5D7
uniprot id: K9K3Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Mitochondrion matrix

9796:CNIH3
gene id: 9796:CNIH3
uniprot id: F7ACZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9796:MRPS31
gene id: 9796:MRPS31
uniprot id: F6YXL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9796:FOXJ3
gene id: 9796:FOXJ3
uniprot id: F6SCJ5
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100051071
gene id: 9796:LOC100051071
uniprot id: F7AAE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GTF2H4
gene id: 9796:GTF2H4
uniprot id: A0A3Q2KYN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9796:ING3
gene id: 9796:ING3
uniprot id: A0A3Q2HY41
uniprot id: F6TZ69
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9796:PARD6A
gene id: 9796:PARD6A
uniprot id: A0A3Q2H243
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9796:PARP11
gene id: 9796:PARP11
uniprot id: F7B5H0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9796:YIPF5
gene id: 9796:YIPF5
uniprot id: F6PLB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9796:ACAD8
gene id: 9796:ACAD8
uniprot id: F6ZTZ5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9796:LOC102147968
gene id: 9796:LOC102147968
uniprot id: F6W7Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MRPS5
gene id: 9796:MRPS5
uniprot id: F6TA96
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9796:ACVR1
gene id: 9796:ACVR1
uniprot id: F7B4G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9796:RIC8A
gene id: 9796:RIC8A
uniprot id: F6QK34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9796:CDK5
gene id: 9796:CDK5
uniprot id: F6YF11
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:ATP1B4
gene id: 9796:ATP1B4
uniprot id: F7AK66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9796:LOC100067067
gene id: 9796:LOC100067067
uniprot id: F7AZC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GNPDA2
gene id: 9796:GNPDA2
uniprot id: A0A3Q2HTN4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9796:ST13
gene id: 9796:ST13
uniprot id: A0A3Q2HLY5
names: Similarity
messages: Belongs to the FAM10 family.

9796:PELO
gene id: 9796:PELO
uniprot id: F6Q4I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: Interacts with PINK1, ABCE1 and CNOT4.
messages: May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
messages: Nucleus

9796:AXL
gene id: 9796:AXL
uniprot id: F6VEV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9796:MRPL19
gene id: 9796:MRPL19
uniprot id: F6ZUG4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9796:FLT1
gene id: 9796:FLT1
uniprot id: F6T133
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9796:RENBP
gene id: 9796:RENBP
uniprot id: F7B0V7
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

9796:DOK6
gene id: 9796:DOK6
uniprot id: A0A5F5PJH3
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9796:MGAT5
gene id: 9796:MGAT5
uniprot id: F7CHI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9796:MTTP
gene id: 9796:MTTP
uniprot id: F6PMI6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:LOC100070767
gene id: 9796:LOC100070767
uniprot id: F7C4X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CYP27A1
gene id: 9796:CYP27A1
uniprot id: F7DXD2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9796:TCEANC2
gene id: 9796:TCEANC2
uniprot id: F6V5Y7
names: Subcellular Location Annotation
messages: Nucleus

9796:SLC29A2
gene id: 9796:SLC29A2
uniprot id: F7AL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9796:DBX1
gene id: 9796:DBX1
uniprot id: F7D891
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100056671
gene id: 9796:LOC100056671
uniprot id: F6ZD83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100058753
gene id: 9796:LOC100058753
uniprot id: F6SL41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CDC5L
gene id: 9796:CDC5L
uniprot id: A0A3Q2KIV9
names: Similarity
messages: Belongs to the CEF1 family.

9796:CD163
gene id: 9796:CD163
uniprot id: F7AC72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:AR
gene id: 9796:AR
uniprot id: F6R5G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9796:SMIM7
gene id: 9796:SMIM7
uniprot id: F6S862
names: Similarity
messages: Belongs to the SMIM7 family.

9796:INHBE
gene id: 9796:INHBE
uniprot id: F6ZTM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9796:HMGB1
gene id: 9796:HMGB1
uniprot id: K9K2L5
uniprot id: Q08IE6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion. Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (By similarity).
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Endosome
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.
messages: HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4. However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance.
messages: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages.
messages: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization. Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM. Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex. Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B c…
messages: In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).
messages: Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by glycyrrhizin. Associates with the TLR4:LY96 receptor complex. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with KPNA1; involved in nuclear import. Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT. Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53. Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response. Interacts with XPO1; mediating nuclear export.
messages: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins.
messages: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding. Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance.
messages: Nucleus
messages: Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion.
messages: Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS (By similarity).
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).
messages: Secreted
messages: The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins.

9796:LOC100053847
gene id: 9796:LOC100053847
uniprot id: A0A3Q2HBF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:LOC100058512
gene id: 9796:LOC100058512
uniprot id: A0A3Q2I4Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PBX1
gene id: 9796:PBX1
uniprot id: A0A3Q2HH85
uniprot id: A0A3Q2HR30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9796:CHURC1
gene id: 9796:CHURC1
uniprot id: A0A5F5Q492
uniprot id: F7A532
names: Similarity
messages: Belongs to the Churchill family.

9796:PSME2
gene id: 9796:PSME2
uniprot id: F7AS57
names: Similarity
messages: Belongs to the PA28 family.

9796:BNIP3L
gene id: 9796:BNIP3L
uniprot id: A0A3Q2LB30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9796:XPO1
gene id: 9796:XPO1
uniprot id: A0A3Q2I6B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9796:NCSTN
gene id: 9796:NCSTN
uniprot id: A0A3Q2LJE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9796:CKAP5
gene id: 9796:CKAP5
uniprot id: F6YL89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

9796:UNC5CL
gene id: 9796:UNC5CL
uniprot id: A0A3Q2HUM3
names: Similarity
messages: Belongs to the unc-5 family.

9796:LOC106780847
gene id: 9796:LOC106780847
uniprot id: F6QTG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:FGF21
gene id: 9796:FGF21
uniprot id: A0A7U3JWE1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9796:MS4A2
gene id: 9796:MS4A2
uniprot id: A0A3Q2HYS4
names: Similarity
messages: Belongs to the MS4A family.

9796:KCNAB3
gene id: 9796:KCNAB3
uniprot id: F7BC63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

9796:LOC100065729
gene id: 9796:LOC100065729
uniprot id: F6Z2U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9796:SH2D1A
gene id: 9796:SH2D1A
uniprot id: A0A3Q2HEL4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9796:GOLGA5
gene id: 9796:GOLGA5
uniprot id: A0A3Q2KJX3
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
messages: Membrane

9796:MTCP1
gene id: 9796:MTCP1
uniprot id: A0A5F5PPG3
names: Similarity
messages: Belongs to the TCL1 family.

9796:KAT8
gene id: 9796:KAT8
uniprot id: F7B2S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9796:GLRA2
gene id: 9796:GLRA2
uniprot id: F7AQJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9796:LYZ
gene id: 9796:LYZ
uniprot id: F7CU94
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

9796:GGCX
gene id: 9796:GGCX
uniprot id: F7DQ43
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
messages: Membrane

9796:SRFBP1
gene id: 9796:SRFBP1
uniprot id: F6U8X7
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9796:XRCC4
gene id: 9796:XRCC4
uniprot id: F7DHF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

9796:PUS7L
gene id: 9796:PUS7L
uniprot id: A0A3Q2KJH1
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9796:SLC13A5
gene id: 9796:SLC13A5
uniprot id: F6RUI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9796:HDC
gene id: 9796:HDC
uniprot id: F6UI58
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9796:LOC100057265
gene id: 9796:LOC100057265
uniprot id: A0A3Q2H9T0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:WASHC3
gene id: 9796:WASHC3
uniprot id: F6RA14
names: Similarity
messages: Belongs to the CCDC53 family.

9796:VPS11
gene id: 9796:VPS11
uniprot id: F7DJ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9796:MEOX1
gene id: 9796:MEOX1
uniprot id: F7AC26
names: Subcellular Location Annotation
messages: Nucleus

9796:EQUCABV1R929
gene id: 9796:EQUCABV1R929
uniprot id: A0A3Q2H8D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:RGS5
gene id: 9796:RGS5
uniprot id: F7C833
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9796:CDH11
gene id: 9796:CDH11
uniprot id: B8K205
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9796:HMGCS1
gene id: 9796:HMGCS1
uniprot id: F6SD16
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9796:LOC100052971
gene id: 9796:LOC100052971
uniprot id: A0A3Q2HLF6
uniprot id: A0A7R8GV06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:UFD1
gene id: 9796:UFD1
uniprot id: H9GZW4
names: Similarity
messages: Belongs to the UFD1 family.

9796:EIF1AX
gene id: 9796:EIF1AX
uniprot id: F7A8G6
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

9796:RAB3C
gene id: 9796:RAB3C
uniprot id: F6ZV39
uniprot id: F7CDC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9796:HOXA6
gene id: 9796:HOXA6
uniprot id: F7CXU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9796:DDIT4
gene id: 9796:DDIT4
uniprot id: F6WW89
names: Similarity
messages: Belongs to the DDIT4 family.

9796:POU3F4
gene id: 9796:POU3F4
uniprot id: F6T3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9796:GPRC5A
gene id: 9796:GPRC5A
uniprot id: F7DS71
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:SLC7A1
gene id: 9796:SLC7A1
uniprot id: F6TT99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9796:BRCC3
gene id: 9796:BRCC3
uniprot id: F6YDI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9796:C18H2orf88
gene id: 9796:C18H2orf88
uniprot id: F6X7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9796:TFEB
gene id: 9796:TFEB
uniprot id: F7E1U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9796:NSUN2
gene id: 9796:NSUN2
uniprot id: F6X1V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9796:MARCH4
gene id: 9796:MARCH4
uniprot id: F7E1M2
names: Subcellular Location Annotation
messages: Membrane

9796:MED19
gene id: 9796:MED19
uniprot id: F7BFP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9796:ACTA2
gene id: 9796:ACTA2
uniprot id: F7CW82
names: Similarity
messages: Belongs to the actin family.

9796:MPC1L
gene id: 9796:MPC1L
uniprot id: F6XQY9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9796:NIM1K
gene id: 9796:NIM1K
uniprot id: F7B2C5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:HIP1
gene id: 9796:HIP1
uniprot id: F6UIN2
names: Similarity
messages: Belongs to the SLA2 family.

9796:LSM12
gene id: 9796:LSM12
uniprot id: F6YE35
names: Similarity
messages: Belongs to the LSM12 family.

9796:LOC100062310
gene id: 9796:LOC100062310
uniprot id: A0A3Q2IAE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LYZL1
gene id: 9796:LYZL1
uniprot id: F7DXW1
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9796:ST6GAL1
gene id: 9796:ST6GAL1
uniprot id: F6SU16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9796:ALKBH8
gene id: 9796:ALKBH8
uniprot id: F7DYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

9796:SF3B1
gene id: 9796:SF3B1
uniprot id: F6WZ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9796:RNF168
gene id: 9796:RNF168
uniprot id: F7DJH7
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with UBE2N/UBC13.
messages: Nucleus
messages: Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
messages: Ubiquitinated.

9796:LOC100057097
gene id: 9796:LOC100057097
uniprot id: F7CH02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MTF2
gene id: 9796:MTF2
uniprot id: F6SPP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9796:SGPL1
gene id: 9796:SGPL1
uniprot id: F6XXU8
names: Similarity
messages: Belongs to the group II decarboxylase family.

9796:ANKZF1
gene id: 9796:ANKZF1
uniprot id: F6YIT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

9796:SDHB
gene id: 9796:SDHB
uniprot id: F6TEX7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9796:NDUFA12
gene id: 9796:NDUFA12
uniprot id: F6UTA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9796:SCAMP4
gene id: 9796:SCAMP4
uniprot id: F6U6S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9796:CDC123
gene id: 9796:CDC123
uniprot id: K9K223
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9796:SOSTDC1
gene id: 9796:SOSTDC1
uniprot id: F6T7A1
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:LOC102149481
gene id: 9796:LOC102149481
uniprot id: F6VUH0
names: Subcellular Location Annotation
messages: Cytoplasm

9796:GLYCTK
gene id: 9796:GLYCTK
uniprot id: F6QH72
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9796:ING4
gene id: 9796:ING4
uniprot id: F6RD70
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9796:CDIP1
gene id: 9796:CDIP1
uniprot id: F7C562
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9796:LOC100059232
gene id: 9796:LOC100059232
uniprot id: A0A3Q2I3V7
names: Similarity
messages: Belongs to the peptidase A1 family.

9796:ZKSCAN5
gene id: 9796:ZKSCAN5
uniprot id: A0A3Q2H1V7
names: Subcellular Location Annotation
messages: Nucleus

9796:KRTAP11-1
gene id: 9796:KRTAP11-1
uniprot id: A0A3Q2HIE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9796:EDC3
gene id: 9796:EDC3
uniprot id: F6S066
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9796:MAOB
gene id: 9796:MAOB
uniprot id: Q5NU31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

9796:PTGFR
gene id: 9796:PTGFR
uniprot id: Q0H0G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:PIGO
gene id: 9796:PIGO
uniprot id: F6XCM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:GRIA2
gene id: 9796:GRIA2
uniprot id: A0A3Q2HK13
uniprot id: A0A3Q2HVY3
uniprot id: F6QNJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9796:LOC100072149
gene id: 9796:LOC100072149
uniprot id: F6ZCX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PMVK
gene id: 9796:PMVK
uniprot id: F6V984
names: Subcellular Location Annotation
messages: cytosol

9796:PTGDS
gene id: 9796:PTGDS
uniprot id: O97921
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: Golgi apparatus
messages: In the male reproductive system, it is expressed in the testis and epididymis, and is secreted into the seminal fluid.
messages: Monomer.
messages: Nucleus membrane
messages: Rough endoplasmic reticulum
messages: Secreted
messages: perinuclear region

9796:DCLK1
gene id: 9796:DCLK1
uniprot id: F7C3P7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9796:GOT1
gene id: 9796:GOT1
uniprot id: A0A5F5Q2J1
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9796:CA3
gene id: 9796:CA3
uniprot id: P07450
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Inhibited by acetazolamide.
messages: Reversible hydration of carbon dioxide.
messages: S-glutathionylated in hepatocytes under oxidative stress.
messages: S-thiolated both by thiol-disulfide exchange with glutathione disulfide and by oxyradical-initiated S-thiolation with reduced glutathione.

9796:APOOL
gene id: 9796:APOOL
uniprot id: K9K206
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9796:PLA2G2F
gene id: 9796:PLA2G2F
uniprot id: F6U5U8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9796:SLCO1C1
gene id: 9796:SLCO1C1
uniprot id: F7E1R5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:ZDHHC9
gene id: 9796:ZDHHC9
uniprot id: A0A3Q2I9T4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9796:TSR1
gene id: 9796:TSR1
uniprot id: F6YAX8
names: Subcellular Location Annotation
messages: nucleolus

9796:ACBD5
gene id: 9796:ACBD5
uniprot id: A0A3Q2HM28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9796:HAUS1
gene id: 9796:HAUS1
uniprot id: F6WUC4
uniprot id: K9K3L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9796:CANT1
gene id: 9796:CANT1
uniprot id: A0A3Q2IF61
names: Similarity
messages: Belongs to the apyrase family.

9796:PFKFB3
gene id: 9796:PFKFB3
uniprot id: A0A3Q2GV94
uniprot id: A0A3Q2HIN2
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9796:AFG1L
gene id: 9796:AFG1L
uniprot id: F6U4W4
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9796:SERINC3
gene id: 9796:SERINC3
uniprot id: F7DKS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9796:MRFAP1
gene id: 9796:MRFAP1
uniprot id: F6WTN4
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9796:LOC100147393
gene id: 9796:LOC100147393
uniprot id: F6V5L6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100067408
gene id: 9796:LOC100067408
uniprot id: F6WVQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MIS12
gene id: 9796:MIS12
uniprot id: F6UU36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9796:SLC6A17
gene id: 9796:SLC6A17
uniprot id: F6YVD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9796:BECN1
gene id: 9796:BECN1
uniprot id: F7AMW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9796:TMEM208
gene id: 9796:TMEM208
uniprot id: F6WAX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9796:DCAF11
gene id: 9796:DCAF11
uniprot id: F6VSE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9796:RPL3
gene id: 9796:RPL3
uniprot id: F6UUX5
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9796:KPNA5
gene id: 9796:KPNA5
uniprot id: F7DMT7
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9796:LOC100055773
gene id: 9796:LOC100055773
uniprot id: A0A5F5PU26
names: Similarity
messages: Belongs to the LCE family.

9796:ANK1
gene id: 9796:ANK1
uniprot id: A0A3Q2H0D3
uniprot id: A0A3Q2H0W2
uniprot id: A0A3Q2I5A9
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9796:LOC106782966
gene id: 9796:LOC106782966
uniprot id: A0A3Q2HP82
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9796:DDAH2
gene id: 9796:DDAH2
uniprot id: F6TY61
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9796:TMEM9B
gene id: 9796:TMEM9B
uniprot id: F6T8G3
names: Similarity
messages: Belongs to the TMEM9 family.

9796:SNRNP27
gene id: 9796:SNRNP27
uniprot id: F6UD79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9796:NOP14
gene id: 9796:NOP14
uniprot id: F6Y0I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9796:INPP1
gene id: 9796:INPP1
uniprot id: F6SRK4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9796:NOS1
gene id: 9796:NOS1
uniprot id: A0A3Q2HV61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOS family.
messages: dendritic spine
messages: sarcolemma

9796:MGP
gene id: 9796:MGP
uniprot id: F6R013
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9796:LMOD3
gene id: 9796:LMOD3
uniprot id: F6UIX7
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9796:GSTA4
gene id: 9796:GSTA4
uniprot id: A0A3Q2HYA5
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9796:LOC100070453
gene id: 9796:LOC100070453
uniprot id: A0A3Q2GVM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ZP3
gene id: 9796:ZP3
uniprot id: F6R6H7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Membrane
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9796:SPOUT1
gene id: 9796:SPOUT1
uniprot id: F6S147
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

9796:CLU
gene id: 9796:CLU
uniprot id: Q29482
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 and PON1. Interacts with the complement complex. Interacts (via alpha chain) with XRCC6. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not interact with BAX in unstressed cells. Found in a complex with LTF, CLU, EPPIN and SEMG1. Interacts (immaturely glycosylated pre-secreted form) with HSPA5; this interaction promotes CLU stability and facilitates stress-induced CLU retrotranslocation from the secretory pathway to the mitochondria, thereby reducing stress-induced apoptosis by stabilizing mitochondrial membrane integrity. Interacts with BCL2L1; this interaction releases and activates BAX and promotes cell death. Interacts with TGFBR2 and ACVR1 (By similarity). Interacts (secreted form) with STMN3; this interaction may act as an important modulator during neuronal differentiation (By similarity). Interacts with VLDLR and LRP8 (By similarity).
messages: Belongs to the clusterin family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity).
messages: Heavily N-glycosylated. About 30% of the protein mass is comprised of complex N-linked carbohydrate. Endoplasmic reticulum (ER) stress induces changes in glycosylation status and increases level of hypoglycosylated forms. Core carbohydrates are essential for chaperone activity. Non-secreted forms are hypoglycosylated or unglycosylated.
messages: Microsome
messages: Mitochondrion
messages: Mitochondrion membrane
messages: Nucleus
messages: Polyubiquitinated, leading to proteasomal degradation. Under cellular stress, the intracellular level of cleaved form is reduced due to proteasomal degradation.
messages: Proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen. Proteolytic cleavage is not necessary for its chaperone activity. All non-secreted forms are not proteolytically cleaved. Chaperone activity of uncleaved forms is dependent on a non-reducing envoronment.
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9796:LOC100070728
gene id: 9796:LOC100070728
uniprot id: F6S0F8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RPAIN
gene id: 9796:RPAIN
uniprot id: F6U2N2
names: Subcellular Location Annotation
messages: Nucleus

9796:SRPRA
gene id: 9796:SRPRA
uniprot id: F7D2J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

9796:OPN1SW
gene id: 9796:OPN1SW
uniprot id: F6U5G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9796:TMED1
gene id: 9796:TMED1
uniprot id: F6YEA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9796:ORMDL1
gene id: 9796:ORMDL1
uniprot id: F6RIL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9796:LRRFIP2
gene id: 9796:LRRFIP2
uniprot id: K9K449
names: Similarity
messages: Belongs to the LRRFIP family.

9796:NUDT5
gene id: 9796:NUDT5
uniprot id: F7BXF9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9796:LOC100059255
gene id: 9796:LOC100059255
uniprot id: F6RWM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100067367
gene id: 9796:LOC100067367
uniprot id: F6V5K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100630858
gene id: 9796:LOC100630858
uniprot id: F7DUC3
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9796:BRINP2
gene id: 9796:BRINP2
uniprot id: F6QRC4
names: Similarity
messages: Belongs to the BRINP family.

9796:NAP1L3
gene id: 9796:NAP1L3
uniprot id: F7APM4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9796:ING2
gene id: 9796:ING2
uniprot id: F6VM00
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9796:FAM192A
gene id: 9796:FAM192A
uniprot id: F6WS27
names: Subcellular Location Annotation
messages: Nucleus

9796:TIMM10
gene id: 9796:TIMM10
uniprot id: F6RDH9
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

9796:LOC100062119
gene id: 9796:LOC100062119
uniprot id: A0A3Q2HJW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LPCAT4
gene id: 9796:LPCAT4
uniprot id: F6U8M0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9796:GSK3B
gene id: 9796:GSK3B
uniprot id: A0A3Q2H039
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

9796:PON2
gene id: 9796:PON2
uniprot id: F6R1T9
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9796:RPL31
gene id: 9796:RPL31
uniprot id: F6YC23
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9796:EQUCABV1R912
gene id: 9796:EQUCABV1R912
uniprot id: A0A3Q2I4X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:SGCG
gene id: 9796:SGCG
uniprot id: F6WMD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

9796:NOX4
gene id: 9796:NOX4
uniprot id: F6RL56
names: Subcellular Location Annotation
messages: Membrane

9796:HSD17B4
gene id: 9796:HSD17B4
uniprot id: Q6RFZ6
names: Subcellular Location Annotation
messages: Peroxisome

9796:GTF2A2
gene id: 9796:GTF2A2
uniprot id: A0A3Q2H461
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9796:LOC100068510
gene id: 9796:LOC100068510
uniprot id: F6SRI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:LOC100070611
gene id: 9796:LOC100070611
uniprot id: A0A3Q2HM82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SSBP1
gene id: 9796:SSBP1
uniprot id: F6RJN1
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9796:RPA3
gene id: 9796:RPA3
uniprot id: F7DBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9796:TMEM265
gene id: 9796:TMEM265
uniprot id: A0A3Q2HW48
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9796:MIP-2BETA
gene id: 9796:MIP-2BETA
uniprot id: B7UBT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9796:SLC25A35
gene id: 9796:SLC25A35
uniprot id: F6TUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:XPNPEP2
gene id: 9796:XPNPEP2
uniprot id: F6X3L0
names: Similarity
messages: Belongs to the peptidase M24B family.

9796:SYNGR4
gene id: 9796:SYNGR4
uniprot id: F6RFA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9796:SARDH
gene id: 9796:SARDH
uniprot id: A0A3Q2I3R6
names: Similarity
messages: Belongs to the GcvT family.

9796:EQUCABV1R901
gene id: 9796:EQUCABV1R901
uniprot id: A0A3Q2I8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:NUSAP1
gene id: 9796:NUSAP1
uniprot id: A0A3Q2I421
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUSAP family.
messages: Cytoplasm

9796:SDE2
gene id: 9796:SDE2
uniprot id: F6V3M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

9796:LOC100063245
gene id: 9796:LOC100063245
uniprot id: F6WLG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9796:GTF2H3
gene id: 9796:GTF2H3
uniprot id: A0A5F5Q3P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9796:UFC1
gene id: 9796:UFC1
uniprot id: F7AEZ6
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9796:PRPF38A
gene id: 9796:PRPF38A
uniprot id: F6UQW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9796:CNOT10
gene id: 9796:CNOT10
uniprot id: A0A5F5PLS9
uniprot id: F6YT67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9796:RPL39
gene id: 9796:RPL39
uniprot id: A0A5F5PP79
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9796:FGR
gene id: 9796:FGR
uniprot id: F7CK20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9796:LOC100066487
gene id: 9796:LOC100066487
uniprot id: F6X3G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HPS6
gene id: 9796:HPS6
uniprot id: F6SBX5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9796:APC
gene id: 9796:APC
uniprot id: A0A3Q2H5U9
uniprot id: A0A3Q2HQN1
uniprot id: F6Y0R6
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9796:MRPL14
gene id: 9796:MRPL14
uniprot id: F6Q6M2
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9796:SEC13
gene id: 9796:SEC13
uniprot id: F6VS25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

9796:LOC100067079
gene id: 9796:LOC100067079
uniprot id: F7DR29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TREM1
gene id: 9796:TREM1
uniprot id: F6PL50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:STK32A
gene id: 9796:STK32A
uniprot id: F7C4R7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:HNRNPA1
gene id: 9796:HNRNPA1
uniprot id: F6YZ44
uniprot id: K9K211
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9796:C15H2orf49
gene id: 9796:C15H2orf49
uniprot id: A0A3Q2H1A1
uniprot id: F7CHE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9796:ZRANB2
gene id: 9796:ZRANB2
uniprot id: A0A5F5PJF2
uniprot id: F7APL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9796:CLCN3
gene id: 9796:CLCN3
uniprot id: A0A3Q2L1L3
uniprot id: F7BZQ7
uniprot id: F7C4U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9796:TSPAN9
gene id: 9796:TSPAN9
uniprot id: F6Y5N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9796:MYT1
gene id: 9796:MYT1
uniprot id: F7BFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9796:TIMP1
gene id: 9796:TIMP1
uniprot id: O02722
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1 (By similarity).
messages: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).
messages: N-glycosylated.
messages: Secreted
messages: The activity of TIMP1 is dependent on the presence of disulfide bonds.

9796:LOC100051359
gene id: 9796:LOC100051359
uniprot id: F7AY78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TRAF1
gene id: 9796:TRAF1
uniprot id: F6ZLL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9796:STEAP2
gene id: 9796:STEAP2
uniprot id: F7DFH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9796:SLC6A1
gene id: 9796:SLC6A1
uniprot id: F6Z3A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9796:TMEM161A
gene id: 9796:TMEM161A
uniprot id: F6ZXN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9796:PFN4
gene id: 9796:PFN4
uniprot id: F7DPL3
names: Similarity
messages: Belongs to the profilin family.

9796:MYADML2
gene id: 9796:MYADML2
uniprot id: F6QK26
names: Subcellular Location Annotation
messages: Membrane

9796:CCDC25
gene id: 9796:CCDC25
uniprot id: F6TDI6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9796:RPP14
gene id: 9796:RPP14
uniprot id: F6ZE73
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9796:TMEM38A
gene id: 9796:TMEM38A
uniprot id: F6RXY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9796:LOC100054253
gene id: 9796:LOC100054253
uniprot id: A0A3Q2IAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:UBE2K
gene id: 9796:UBE2K
uniprot id: F7DTQ9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9796:MCL1
gene id: 9796:MCL1
uniprot id: F7AVA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

9796:CDK1
gene id: 9796:CDK1
uniprot id: K9K3T8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:LOC100034175
gene id: 9796:LOC100034175
uniprot id: P00328
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Dimer of identical or non-identical chains of two types (E and S) coded by 2 separate genes at different loci.

9796:TM4SF4
gene id: 9796:TM4SF4
uniprot id: F6TR36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9796:SLC16A7
gene id: 9796:SLC16A7
uniprot id: F6WT11
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

9796:LDHA
gene id: 9796:LDHA
uniprot id: B7XH73
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9796:PSD4
gene id: 9796:PSD4
uniprot id: A0A3Q2I0L0
names: Subcellular Location Annotation
messages: ruffle membrane

9796:SLC24A2
gene id: 9796:SLC24A2
uniprot id: F7E0G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9796:LALBA
gene id: 9796:LALBA
uniprot id: A0A5K1V2X0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9796:S100A16
gene id: 9796:S100A16
uniprot id: F7C5Z7
names: Similarity
messages: Belongs to the S-100 family.

9796:CTBP2
gene id: 9796:CTBP2
uniprot id: A0A3Q2H467
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9796:PTGER3
gene id: 9796:PTGER3
uniprot id: A0A3Q2GY90
uniprot id: A0A5F5Q247
uniprot id: F7A1L9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:LOC100052568
gene id: 9796:LOC100052568
uniprot id: A0A3Q2ID58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:NUP35
gene id: 9796:NUP35
uniprot id: K9K270
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9796:LOC100058329
gene id: 9796:LOC100058329
uniprot id: F6Z2I7
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9796:LOC100065039
gene id: 9796:LOC100065039
uniprot id: A0A3Q2KMY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9796:S100A10
gene id: 9796:S100A10
uniprot id: F7BKY7
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9796:TMPRSS15
gene id: 9796:TMPRSS15
uniprot id: F7AVP5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMBT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:PLA2G2A
gene id: 9796:PLA2G2A
uniprot id: A0A5K1UTF7
uniprot id: A3RLX2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9796:C2H1orf123
gene id: 9796:C2H1orf123
uniprot id: A0A5F5PET2
names: Similarity
messages: Belongs to the UPF0587 family.

9796:RGS2
gene id: 9796:RGS2
uniprot id: B7X6D7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

9796:FABP9
gene id: 9796:FABP9
uniprot id: F6ZE69
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9796:KCNA6
gene id: 9796:KCNA6
uniprot id: F7DZR3
names: Subcellular Location Annotation
messages: Membrane

9796:EPB42
gene id: 9796:EPB42
uniprot id: F6ZDW1
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

9796:COMP
gene id: 9796:COMP
uniprot id: Q9BG80
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:DMBX1
gene id: 9796:DMBX1
uniprot id: F6R755
names: Subcellular Location Annotation
messages: Nucleus

9796:DLL4
gene id: 9796:DLL4
uniprot id: F7BDL8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9796:ALDH7A1
gene id: 9796:ALDH7A1
uniprot id: F7CZV6
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

9796:BLOC1S2
gene id: 9796:BLOC1S2
uniprot id: F7BCZ6
names: Similarity
messages: Belongs to the BLOC1S2 family.

9796:PPIH
gene id: 9796:PPIH
uniprot id: F6YTQ2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9796:CDK4
gene id: 9796:CDK4
uniprot id: F6QM47
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:RIBC1
gene id: 9796:RIBC1
uniprot id: A0A3Q2LJM4
uniprot id: F7ARN9
names: Similarity
messages: Belongs to the RIB43A family.

9796:NR5A2
gene id: 9796:NR5A2
uniprot id: Q9GKL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9796:FGF9
gene id: 9796:FGF9
uniprot id: F7B6A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
messages: Secreted

9796:SGCD
gene id: 9796:SGCD
uniprot id: F6TWW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9796:GAD2
gene id: 9796:GAD2
uniprot id: F7D4X1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9796:LOC100053645
gene id: 9796:LOC100053645
uniprot id: A0A5F5PTX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:CLRN3
gene id: 9796:CLRN3
uniprot id: F7BXA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9796:LOC100629356
gene id: 9796:LOC100629356
uniprot id: F6TV44
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MYH10
gene id: 9796:MYH10
uniprot id: A0A3Q2I8P4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9796:TBP
gene id: 9796:TBP
uniprot id: F6UBP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9796:CASK
gene id: 9796:CASK
uniprot id: A0A3Q2HV90
uniprot id: F7DK34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9796:DCTN6
gene id: 9796:DCTN6
uniprot id: K9K3S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9796:LOC100050100
gene id: 9796:LOC100050100
uniprot id: A0A3Q2GS71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9796:LOC100053259
gene id: 9796:LOC100053259
uniprot id: F6Y7V5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:CEP44
gene id: 9796:CEP44
uniprot id: A0A5F5PIS2
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9796:AMT
gene id: 9796:AMT
uniprot id: A0A5F5PL15
uniprot id: F6RYP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9796:EHD3
gene id: 9796:EHD3
uniprot id: F7CVS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9796:LOC106782672
gene id: 9796:LOC106782672
uniprot id: A0A3Q2HQ09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9796:ADAM30
gene id: 9796:ADAM30
uniprot id: A0A3Q2HDW8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:KEF40 p03
gene id: 9796:KEF40_p03
uniprot id: G4RIU1
uniprot id: P48656
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9796:PDE6H
gene id: 9796:PDE6H
uniprot id: A0A5F5PJH2
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9796:NUP133
gene id: 9796:NUP133
uniprot id: F6U4N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

9796:DMRTC2
gene id: 9796:DMRTC2
uniprot id: A0A3Q2IAT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9796:ERLIN1
gene id: 9796:ERLIN1
uniprot id: A0A3Q2GVX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9796:ZDHHC7
gene id: 9796:ZDHHC7
uniprot id: F6RLG3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9796:DPM3
gene id: 9796:DPM3
uniprot id: F7E293
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

9796:STMN1
gene id: 9796:STMN1
uniprot id: K9K1Z1
names: Similarity
messages: Belongs to the stathmin family.

9796:CPLX2
gene id: 9796:CPLX2
uniprot id: F7CYS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9796:GDA
gene id: 9796:GDA
uniprot id: F7C708
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9796:EFNA4
gene id: 9796:EFNA4
uniprot id: F6ZGF1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:ACAA1
gene id: 9796:ACAA1
uniprot id: F6R7Z1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9796:LOC100062825
gene id: 9796:LOC100062825
uniprot id: A0A5F5PRK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ZNF396
gene id: 9796:ZNF396
uniprot id: A0A3Q2I8J6
names: Subcellular Location Annotation
messages: Nucleus

9796:TBX18
gene id: 9796:TBX18
uniprot id: F7B1K4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9796:LOC100068268
gene id: 9796:LOC100068268
uniprot id: F6UPS8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:AMPD3
gene id: 9796:AMPD3
uniprot id: F6V9E7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9796:LOC100058710
gene id: 9796:LOC100058710
uniprot id: F7DAQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NCBP1
gene id: 9796:NCBP1
uniprot id: A0A3Q2GT55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9796:LOC100070169
gene id: 9796:LOC100070169
uniprot id: F7D6S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ATP6V0D1
gene id: 9796:ATP6V0D1
uniprot id: F6TST3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9796:LOC102148892
gene id: 9796:LOC102148892
uniprot id: A0A3Q2HPB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9796:LOC100062019
gene id: 9796:LOC100062019
uniprot id: F6YSJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100072638
gene id: 9796:LOC100072638
uniprot id: F7A4U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NPHS2
gene id: 9796:NPHS2
uniprot id: F6WST7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9796:INTS3
gene id: 9796:INTS3
uniprot id: F6U224
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9796:CRYAB
gene id: 9796:CRYAB
uniprot id: F6SYI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9796:HTR6
gene id: 9796:HTR6
uniprot id: F6S7S0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:SKP1
gene id: 9796:SKP1
uniprot id: F6S4R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

9796:PRDM1
gene id: 9796:PRDM1
uniprot id: A0A3Q2GTP0
uniprot id: A0A3Q2LBT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9796:DBR1
gene id: 9796:DBR1
uniprot id: A0A3Q2HBT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

9796:LOC100067462
gene id: 9796:LOC100067462
uniprot id: F6TT29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NDST2
gene id: 9796:NDST2
uniprot id: F7AV98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9796:ITGA10
gene id: 9796:ITGA10
uniprot id: A0A3Q2H7P4
uniprot id: A0A3Q2HRS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9796:CDH10
gene id: 9796:CDH10
uniprot id: F7B2F9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9796:KIF18B
gene id: 9796:KIF18B
uniprot id: F6U8L2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:GORASP2
gene id: 9796:GORASP2
uniprot id: F7BBI4
names: Similarity
messages: Belongs to the GORASP family.

9796:ATG4A
gene id: 9796:ATG4A
uniprot id: A0A3Q2IF01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9796:SLC2A2
gene id: 9796:SLC2A2
uniprot id: Q6KBW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9796:SOAT2
gene id: 9796:SOAT2
uniprot id: F7E413
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:KDELR1
gene id: 9796:KDELR1
uniprot id: F6RT52
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:GPR132
gene id: 9796:GPR132
uniprot id: F6Z8M2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:CXCL2
gene id: 9796:CXCL2
uniprot id: B7UBX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9796:LOC100053409
gene id: 9796:LOC100053409
uniprot id: A0A3Q2I1F8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9796:FGF6
gene id: 9796:FGF6
uniprot id: F6YKX9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9796:LOC100066878
gene id: 9796:LOC100066878
uniprot id: F6VXV6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PRM2
gene id: 9796:PRM2
uniprot id: F7VJL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protamine P2 family.
messages: Interacts with TDRP.
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

9796:ECATH-2
gene id: 9796:ECATH-2
uniprot id: O62841
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9796:ARMCX2
gene id: 9796:ARMCX2
uniprot id: F6XU55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9796:NONO
gene id: 9796:NONO
uniprot id: F6UBF6
names: Subcellular Location Annotation
messages: Nucleus speckle

9796:SPG21
gene id: 9796:SPG21
uniprot id: A0A3Q2ICZ1
names: Function
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9796:LOC100054473
gene id: 9796:LOC100054473
uniprot id: A0A3Q2LQZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:LOC100057541
gene id: 9796:LOC100057541
uniprot id: F7A163
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RPAP1
gene id: 9796:RPAP1
uniprot id: F6R341
names: Similarity
messages: Belongs to the RPAP1 family.

9796:TRIM32
gene id: 9796:TRIM32
uniprot id: F6YCR4
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9796:LOC100072195
gene id: 9796:LOC100072195
uniprot id: A0A3Q2I3X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RLN
gene id: 9796:RLN
uniprot id: P22969
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
messages: Secreted

9796:FAM3A
gene id: 9796:FAM3A
uniprot id: F6ZY43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9796:GNGT1
gene id: 9796:GNGT1
uniprot id: F7B1I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9796:CRKL
gene id: 9796:CRKL
uniprot id: A0A3Q2H3L6
names: Similarity
messages: Belongs to the CRK family.

9796:WISP1
gene id: 9796:WISP1
uniprot id: A0A5F5PHM4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:CACNG7
gene id: 9796:CACNG7
uniprot id: F6QL00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

9796:RNASE11
gene id: 9796:RNASE11
uniprot id: F6TU58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9796:ARRDC3
gene id: 9796:ARRDC3
uniprot id: F7BVB7
names: Similarity
messages: Belongs to the arrestin family.

9796:CXHXorf56
gene id: 9796:CXHXorf56
uniprot id: F6TB37
names: Similarity
messages: Belongs to the STEEP1 family.

9796:GALR1
gene id: 9796:GALR1
uniprot id: F7DSS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9796:GLUL
gene id: 9796:GLUL
uniprot id: F6TAZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Membrane
messages: Microsome

9796:LOC100056800
gene id: 9796:LOC100056800
uniprot id: F6X7Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SFMBT1
gene id: 9796:SFMBT1
uniprot id: F7CSA8
names: Subcellular Location Annotation
messages: Nucleus

9796:PGFS
gene id: 9796:PGFS
uniprot id: Q6W8P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the aldo/keto reductase family.
messages: Cytoplasm
messages: Detected in endometrium surface epithelium (at protein level). Detected in endometrium.
messages: Monomer.
messages: NADP-dependent oxidoreductase involved in steroid metabolism. May act on various hydroxysteroids.

9796:ATP5F1A
gene id: 9796:ATP5F1A
uniprot id: F6XUJ2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9796:LOC100065068
gene id: 9796:LOC100065068
uniprot id: B5BV12
names: Similarity
messages: Belongs to the serpin family.

9796:KDELC1
gene id: 9796:KDELC1
uniprot id: F7BK32
names: Similarity
messages: Belongs to the KDELC family.

9796:RELL2
gene id: 9796:RELL2
uniprot id: F7CFS4
names: Similarity
messages: Belongs to the RELT family.

9796:HSD3B2
gene id: 9796:HSD3B2
uniprot id: O46516
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
messages: Belongs to the 3-beta-HSD family.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane

9796:PRNP
gene id: 9796:PRNP
uniprot id: B5B2G8
uniprot id: B5B2H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane

9796:DLX1
gene id: 9796:DLX1
uniprot id: F6QWX6
names: Subcellular Location Annotation
messages: Nucleus

9796:SNW1
gene id: 9796:SNW1
uniprot id: F7ACV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9796:SULT6B1
gene id: 9796:SULT6B1
uniprot id: F6XSH3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9796:FGGY
gene id: 9796:FGGY
uniprot id: A0A3Q2I3F9
names: Similarity
messages: Belongs to the FGGY kinase family.

9796:ELOVL1
gene id: 9796:ELOVL1
uniprot id: F7DSS8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9796:TSTA3
gene id: 9796:TSTA3
uniprot id: F7B8D4
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9796:ITGAE
gene id: 9796:ITGAE
uniprot id: F6WV98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9796:AURKA
gene id: 9796:AURKA
uniprot id: A0A3Q2LCY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9796:YIPF6
gene id: 9796:YIPF6
uniprot id: F7DUA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9796:GRK7
gene id: 9796:GRK7
uniprot id: F7AW96
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9796:GINS4
gene id: 9796:GINS4
uniprot id: F6VZF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9796:CYP2D50
gene id: 9796:CYP2D50
uniprot id: A8W4X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:REEP4
gene id: 9796:REEP4
uniprot id: F6UY63
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:GAST
gene id: 9796:GAST
uniprot id: F6SYU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9796:HK3
gene id: 9796:HK3
uniprot id: A0A3Q2HQY3
uniprot id: F6Z3G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9796:GLMP
gene id: 9796:GLMP
uniprot id: F6PIM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9796:ACTR6
gene id: 9796:ACTR6
uniprot id: F7AZA0
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

9796:PSEN1
gene id: 9796:PSEN1
uniprot id: F6SAM1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9796:RPL7
gene id: 9796:RPL7
uniprot id: F6Y0N4
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9796:TELO2
gene id: 9796:TELO2
uniprot id: F6S0T2
names: Similarity
messages: Belongs to the TEL2 family.

9796:SLC6A4
gene id: 9796:SLC6A4
uniprot id: F6QG30
uniprot id: Q14UY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: focal adhesion

9796:GABPA
gene id: 9796:GABPA
uniprot id: F7B0D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:CYP17A1
gene id: 9796:CYP17A1
uniprot id: A0A140TAU9
uniprot id: Q95328
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity.

9796:S100Z
gene id: 9796:S100Z
uniprot id: F7CVX9
names: Similarity
messages: Belongs to the S-100 family.

9796:FBXO9
gene id: 9796:FBXO9
uniprot id: A0A3Q2HT68
names: Subcellular Location Annotation
messages: Cytoplasm

9796:DDO
gene id: 9796:DDO
uniprot id: A0A3Q2HTI1
uniprot id: F7DD42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9796:CLVS1
gene id: 9796:CLVS1
uniprot id: F7D5B5
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9796:STARD3NL
gene id: 9796:STARD3NL
uniprot id: A0A3Q2HBZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9796:STX6
gene id: 9796:STX6
uniprot id: A0A3Q2LU00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9796:NDRG3
gene id: 9796:NDRG3
uniprot id: A0A3Q2HW41
uniprot id: F6XGJ6
uniprot id: F6XGK2
names: Similarity
messages: Belongs to the NDRG family.

9796:OXSM
gene id: 9796:OXSM
uniprot id: F7C6A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9796:POU1F1
gene id: 9796:POU1F1
uniprot id: F6X4N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Nucleus

9796:CLDN3
gene id: 9796:CLDN3
uniprot id: A0A3Q2KQG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:TNNI3
gene id: 9796:TNNI3
uniprot id: Q5PYI0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the troponin I family.
messages: Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1 (By similarity).
messages: Phosphorylated at Ser-17 and Ser-18 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-26. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylated at Ser-37 and Ser-39 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity).
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9796:SLCO6A1
gene id: 9796:SLCO6A1
uniprot id: F7CMN7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:CTNNB1
gene id: 9796:CTNNB1
uniprot id: B1MV73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9796:MS4A7
gene id: 9796:MS4A7
uniprot id: A0A3Q2HVL5
names: Similarity
messages: Belongs to the MS4A family.

9796:C7H11orf88
gene id: 9796:C7H11orf88
uniprot id: F6VXR2
names: Similarity
messages: Belongs to the HOATZ family.

9796:NGRN
gene id: 9796:NGRN
uniprot id: F6Q6Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9796:NQO1
gene id: 9796:NQO1
uniprot id: F6W6Z4
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9796:PGBD1
gene id: 9796:PGBD1
uniprot id: F6T8I0
names: Subcellular Location Annotation
messages: Nucleus

9796:TMBIM6
gene id: 9796:TMBIM6
uniprot id: F7BJX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9796:LOC100061689
gene id: 9796:LOC100061689
uniprot id: A0A3Q2LGT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GSPT1
gene id: 9796:GSPT1
uniprot id: F6YDK2
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9796:RNASEK
gene id: 9796:RNASEK
uniprot id: A0A3Q2HLL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Membrane

9796:MMP9
gene id: 9796:MMP9
uniprot id: A8HDR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

9796:AMZ1
gene id: 9796:AMZ1
uniprot id: F6QZ01
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9796:HAPLN2
gene id: 9796:HAPLN2
uniprot id: F6VVF9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9796:CABS1
gene id: 9796:CABS1
uniprot id: A0A5F5PKL5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: acrosome
messages: flagellum

9796:DEDD
gene id: 9796:DEDD
uniprot id: F7BC30
names: Subcellular Location Annotation
messages: nucleolus

9796:COPS5
gene id: 9796:COPS5
uniprot id: F7AU83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9796:FAM19A2
gene id: 9796:FAM19A2
uniprot id: A0A5F5PT35
names: Similarity
messages: Belongs to the TAFA family.

9796:TLR10
gene id: 9796:TLR10
uniprot id: F6VHZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9796:ARID5B
gene id: 9796:ARID5B
uniprot id: A0A5F5PMV3
names: Similarity
messages: Belongs to the ARID5B family.

9796:COPB1
gene id: 9796:COPB1
uniprot id: F6YZP7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9796:TPM3
gene id: 9796:TPM3
uniprot id: A0A3Q2HP43
uniprot id: A0A5F5PGV6
uniprot id: A0A5F5PMP6
uniprot id: A0A5F5PT26
uniprot id: A0A5F5PYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9796:MET
gene id: 9796:MET
uniprot id: A0A3Q2HWY0
uniprot id: Q2QLA9
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9796:ADORA2A
gene id: 9796:ADORA2A
uniprot id: Q6TLI7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (By similarity). May interact with DRD4 (By similarity). Interacts with NECAB2 (By similarity). Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (By similarity).
messages: Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
messages: The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.
messages: Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).

9796:SATB2
gene id: 9796:SATB2
uniprot id: F6PZN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9796:HYAL2
gene id: 9796:HYAL2
uniprot id: A0A3Q2H6H1
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9796:ZKSCAN8
gene id: 9796:ZKSCAN8
uniprot id: F6QT97
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100057421
gene id: 9796:LOC100057421
uniprot id: A0A3Q2HWN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:FLOT1
gene id: 9796:FLOT1
uniprot id: F6Z0M9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: Membrane
messages: caveola

9796:LOC100629951
gene id: 9796:LOC100629951
uniprot id: B3GDZ0
uniprot id: P05003
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
messages: Secreted

9796:TMEFF2
gene id: 9796:TMEFF2
uniprot id: F6VIK8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:CHRNB1
gene id: 9796:CHRNB1
uniprot id: F6SLE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:RSPO4
gene id: 9796:RSPO4
uniprot id: F6VH10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9796:NMNAT1
gene id: 9796:NMNAT1
uniprot id: F6TI31
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9796:DCLRE1B
gene id: 9796:DCLRE1B
uniprot id: F6Z5I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9796:SYNGR3
gene id: 9796:SYNGR3
uniprot id: F7DM65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9796:CEP55
gene id: 9796:CEP55
uniprot id: A0A3Q2HJW7
names: Subcellular Location Annotation
messages: Cytoplasm

9796:C1R
gene id: 9796:C1R
uniprot id: F6Z5L1
names: Caution
names: Function
names: Subunit
messages: C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.
messages: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:LOC100072648
gene id: 9796:LOC100072648
uniprot id: F6VH22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100053791
gene id: 9796:LOC100053791
uniprot id: A0A3Q2KXW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9796:LOC100057631
gene id: 9796:LOC100057631
uniprot id: A0A3Q2GU40
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RAD1
gene id: 9796:RAD1
uniprot id: F6YZW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9796:CORO1A
gene id: 9796:CORO1A
uniprot id: F6Q6X3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

9796:GNLY
gene id: 9796:GNLY
uniprot id: Q8HZQ3
names: Function
names: Subcellular Location Annotation
messages: May be an effector molecule of cytotoxic activity. Has antimicrobial activity (By similarity).
messages: Secreted

9796:FAM91A1
gene id: 9796:FAM91A1
uniprot id: F7ATK2
names: Similarity
messages: Belongs to the FAM91 family.

9796:HSPA1A
gene id: 9796:HSPA1A
uniprot id: F7DW69
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9796:COG1
gene id: 9796:COG1
uniprot id: A0A3Q2IA67
uniprot id: F6WB16
names: Similarity
messages: Belongs to the COG1 family.

9796:C9
gene id: 9796:C9
uniprot id: P48770
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. About 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target membranes.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
messages: Secreted
messages: Target cell membrane
messages: The structure of the human polymeric form indicates the existence of an additional disulfide bond compared to the mouse monomeric form.
messages: Thrombin cleaves factor C9 to produce C9a and C9b.

9796:MCHR1
gene id: 9796:MCHR1
uniprot id: F7B4J6
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

9796:EIF2S1
gene id: 9796:EIF2S1
uniprot id: F7CTS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9796:CPNE8
gene id: 9796:CPNE8
uniprot id: A0A3Q2HGA9
names: Similarity
messages: Belongs to the copine family.

9796:KEF40 p09
gene id: 9796:KEF40_p09
uniprot id: P48663
uniprot id: Q6J6X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9796:MED14
gene id: 9796:MED14
uniprot id: F7C7L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9796:FCER1G
gene id: 9796:FCER1G
uniprot id: A0A0B4J1B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9796:PFDN5
gene id: 9796:PFDN5
uniprot id: A0A3Q2KJ50
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9796:VTA1
gene id: 9796:VTA1
uniprot id: F6ZAQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9796:RPP30
gene id: 9796:RPP30
uniprot id: A0A3Q2LLU6
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9796:LOC100062539
gene id: 9796:LOC100062539
uniprot id: F7DUV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:UBE2E3
gene id: 9796:UBE2E3
uniprot id: F7CH20
uniprot id: L7MRP4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9796:RXFP4
gene id: 9796:RXFP4
uniprot id: A0A5F5PME6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:NANOG
gene id: 9796:NANOG
uniprot id: F6PXN9
names: Subcellular Location Annotation
messages: Nucleus

9796:HFE
gene id: 9796:HFE
uniprot id: A0A3Q2KYQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MHC class I family.
messages: Binds TFR through the extracellular domain in a pH-dependent manner.
messages: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
messages: Cell membrane

9796:NKAIN2
gene id: 9796:NKAIN2
uniprot id: A0A3Q2KQT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9796:LOC100069198
gene id: 9796:LOC100069198
uniprot id: A0A5F5PUF1
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9796:LOC100068520
gene id: 9796:LOC100068520
uniprot id: F6TUQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:BTBD10
gene id: 9796:BTBD10
uniprot id: A0A5F5PNG6
uniprot id: A0A5F5PV62
uniprot id: F6WPF9
names: Subcellular Location Annotation
messages: Cytoplasm

9796:COX7A2L
gene id: 9796:COX7A2L
uniprot id: F7CBF8
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9796:LOC100069426
gene id: 9796:LOC100069426
uniprot id: F6XNV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:UNC5C
gene id: 9796:UNC5C
uniprot id: F7BUW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9796:CTSE
gene id: 9796:CTSE
uniprot id: F6Q1N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Homodimer; disulfide-linked.
messages: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

9796:LOC100058123
gene id: 9796:LOC100058123
uniprot id: F7CSF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HBA
gene id: 9796:HBA
uniprot id: A0A3Q2H875
uniprot id: P01958
names: Function
names: Polymorphism
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Horse has two non-allelic alpha chains, slow and fast. The slow chain sequence is shown.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9796:UBLCP1
gene id: 9796:UBLCP1
uniprot id: F7BKH3
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9796:GABRB3
gene id: 9796:GABRB3
uniprot id: F6ZJU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:RUVBL2
gene id: 9796:RUVBL2
uniprot id: F6X277
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9796:LOC100052624
gene id: 9796:LOC100052624
uniprot id: F7B9F5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:MCM3
gene id: 9796:MCM3
uniprot id: F6VAG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9796:CPSF3
gene id: 9796:CPSF3
uniprot id: F7CPI2
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100052727
gene id: 9796:LOC100052727
uniprot id: A0A3Q2HUK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9796:LOC100057392
gene id: 9796:LOC100057392
uniprot id: F6QRK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:KEF40 p02
gene id: 9796:KEF40_p02
uniprot id: P48657
uniprot id: Q6J6W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9796:PTGR2
gene id: 9796:PTGR2
uniprot id: F6T1P0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9796:NDC1
gene id: 9796:NDC1
uniprot id: F6YIE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

9796:F11R
gene id: 9796:F11R
uniprot id: F7B6C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9796:TRAF3
gene id: 9796:TRAF3
uniprot id: A0A3Q2I5E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9796:LOC100068584
gene id: 9796:LOC100068584
uniprot id: F7D6U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TNFSF4
gene id: 9796:TNFSF4
uniprot id: F6UJR4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9796:OGFOD1
gene id: 9796:OGFOD1
uniprot id: F7E160
names: Similarity
messages: Belongs to the TPA1 family.

9796:FEZ1
gene id: 9796:FEZ1
uniprot id: A4UZ22
uniprot id: F7E280
names: Similarity
messages: Belongs to the zygin family.

9796:GPBP1
gene id: 9796:GPBP1
uniprot id: A0A3Q2H334
uniprot id: A0A3Q2LN23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9796:SLITRK3
gene id: 9796:SLITRK3
uniprot id: F7D5P1
names: Similarity
messages: Belongs to the SLITRK family.

9796:LOC100071445
gene id: 9796:LOC100071445
uniprot id: F6X727
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LIN54
gene id: 9796:LIN54
uniprot id: F6WTY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9796:ANXA7
gene id: 9796:ANXA7
uniprot id: A0A5F5PP70
uniprot id: F7ALC9
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9796:FMC1
gene id: 9796:FMC1
uniprot id: F6RYC9
names: Similarity
messages: Belongs to the FMC1 family.

9796:IL12B
gene id: 9796:IL12B
uniprot id: Q9XSQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Secreted

9796:PDP2
gene id: 9796:PDP2
uniprot id: F7A4F3
names: Similarity
messages: Belongs to the PP2C family.

9796:TAS2R8
gene id: 9796:TAS2R8
uniprot id: F6XMV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9796:PISD
gene id: 9796:PISD
uniprot id: A0A3Q2KYT2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9796:TMEM150C
gene id: 9796:TMEM150C
uniprot id: F6S0W9
names: Subcellular Location Annotation
messages: Membrane

9796:CYP3A94
gene id: 9796:CYP3A94
uniprot id: D7GB57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:PRPH
gene id: 9796:PRPH
uniprot id: F7DQ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon

9796:OAS2
gene id: 9796:OAS2
uniprot id: Q6R757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9796:PPAT
gene id: 9796:PPAT
uniprot id: A0A3Q2HYL9
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9796:EEF1G
gene id: 9796:EEF1G
uniprot id: A2Q127
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9796:FZD4
gene id: 9796:FZD4
uniprot id: A0A3Q2LRA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9796:FMO5
gene id: 9796:FMO5
uniprot id: F6PLR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9796:CASTOR1
gene id: 9796:CASTOR1
uniprot id: F6YEZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

9796:EPHA7
gene id: 9796:EPHA7
uniprot id: F6Z105
names: Subcellular Location Annotation
messages: Membrane

9796:IDH3G
gene id: 9796:IDH3G
uniprot id: A0A5F5PUH0
uniprot id: F7A4P6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9796:GHSR
gene id: 9796:GHSR
uniprot id: F6QF00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

9796:LOC106783049
gene id: 9796:LOC106783049
uniprot id: F7CV46
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9796:LOC100062551
gene id: 9796:LOC100062551
uniprot id: F6Y9I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100053225
gene id: 9796:LOC100053225
uniprot id: F7DHU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ENPP2
gene id: 9796:ENPP2
uniprot id: A0A3Q2H8V4
uniprot id: A0A3Q2HYR4
uniprot id: F6Z7T9
uniprot id: F6Z7X8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

9796:LOC100057747
gene id: 9796:LOC100057747
uniprot id: A0A3Q2H1K4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:EIF2A
gene id: 9796:EIF2A
uniprot id: F6PZJ0
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9796:LOC100052677
gene id: 9796:LOC100052677
uniprot id: A0A5K1U7C0
names: Subcellular Location Annotation
messages: Nucleus

9796:NOXA1
gene id: 9796:NOXA1
uniprot id: F7AD30
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9796:ATP4B
gene id: 9796:ATP4B
uniprot id: F7E4M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9796:DUOXA1
gene id: 9796:DUOXA1
uniprot id: F6YES2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9796:DSE
gene id: 9796:DSE
uniprot id: F6TYR9
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9796:SEC22C
gene id: 9796:SEC22C
uniprot id: A0A5F5Q251
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9796:RAB4B
gene id: 9796:RAB4B
uniprot id: F6VAP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9796:UBE2A
gene id: 9796:UBE2A
uniprot id: F7BNF7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9796:RHBDD1
gene id: 9796:RHBDD1
uniprot id: F7CEC7
names: Subcellular Location Annotation
messages: Membrane

9796:SERPINB9
gene id: 9796:SERPINB9
uniprot id: F6Q892
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9796:ACP5
gene id: 9796:ACP5
uniprot id: F6WFF6
names: Cofactor
messages: Binds 2 iron ions per subunit.

9796:TMEM255A
gene id: 9796:TMEM255A
uniprot id: A0A3Q2H8N1
uniprot id: A0A3Q2LBD0
uniprot id: F6YZ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9796:PNPLA4
gene id: 9796:PNPLA4
uniprot id: A0A3Q2HCH7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:MATN2
gene id: 9796:MATN2
uniprot id: A0A5F5PRJ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:TXNL4A
gene id: 9796:TXNL4A
uniprot id: F7B0J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9796:CRISP3
gene id: 9796:CRISP3
uniprot id: O19010
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CRISP family.
messages: Expressed in the salivary gland, in the ampulla and the seminal vesicle.
messages: Interacts with A1BG.
messages: Secreted

9796:SLC25A30
gene id: 9796:SLC25A30
uniprot id: F7A6C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:FAM167B
gene id: 9796:FAM167B
uniprot id: F6QTQ8
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9796:GDE1
gene id: 9796:GDE1
uniprot id: F6S8V0
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9796:ILK
gene id: 9796:ILK
uniprot id: A0A3Q2H733
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9796:ELF1
gene id: 9796:ELF1
uniprot id: F6QPQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:LOC100630282
gene id: 9796:LOC100630282
uniprot id: F6ZRT3
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9796:ROS1
gene id: 9796:ROS1
uniprot id: F6XJD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9796:CHI3L1
gene id: 9796:CHI3L1
uniprot id: A0A3Q2LG11
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Endoplasmic reticulum
messages: Monomer.
messages: extracellular space
messages: perinuclear region

9796:MED17
gene id: 9796:MED17
uniprot id: F6ZKW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9796:STS
gene id: 9796:STS
uniprot id: F6YUW4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9796:SPATA6L
gene id: 9796:SPATA6L
uniprot id: F6WKS4
names: Similarity
messages: Belongs to the SPATA6 family.

9796:MSTN
gene id: 9796:MSTN
uniprot id: Q9GM97
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted
messages: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

9796:CXCR6
gene id: 9796:CXCR6
uniprot id: F6XQ88
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:ARPC3
gene id: 9796:ARPC3
uniprot id: F6WE31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9796:LOC100066603
gene id: 9796:LOC100066603
uniprot id: F6W6T5
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9796:HRH4
gene id: 9796:HRH4
uniprot id: D6QXZ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:SLC4A2
gene id: 9796:SLC4A2
uniprot id: Q6SJP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (By similarity). Plays an important role in osteoclast differentiation and function (By similarity). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell response (By similarity).

9796:ERMN
gene id: 9796:ERMN
uniprot id: F6Y4D3
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9796:ARF4
gene id: 9796:ARF4
uniprot id: F6S0P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9796:LOC100061995
gene id: 9796:LOC100061995
uniprot id: A0A3Q2HQW8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ROM1
gene id: 9796:ROM1
uniprot id: F6ZI75
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9796:C26H21orf59
gene id: 9796:C26H21orf59
uniprot id: F7BYY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9796:SFTPC
gene id: 9796:SFTPC
uniprot id: F6URC7
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: surface film

9796:SLC35C2
gene id: 9796:SLC35C2
uniprot id: F6Q4W4
names: Subcellular Location Annotation
messages: Membrane

9796:PRND
gene id: 9796:PRND
uniprot id: A2BDI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9796:FGF11
gene id: 9796:FGF11
uniprot id: F6RW88
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9796:EIF4E2
gene id: 9796:EIF4E2
uniprot id: A0A5F5PF28
uniprot id: A0A5F5PTM9
uniprot id: F7DBU9
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9796:LOC100073309
gene id: 9796:LOC100073309
uniprot id: F7CUQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TSN
gene id: 9796:TSN
uniprot id: A0A5F5PHL5
uniprot id: F6UCZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9796:TRHDE
gene id: 9796:TRHDE
uniprot id: F6PTN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Membrane

9796:NPM3
gene id: 9796:NPM3
uniprot id: F7CKP2
names: Similarity
messages: Belongs to the nucleoplasmin family.

9796:ATP6V1A
gene id: 9796:ATP6V1A
uniprot id: A0A3Q2HRX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

9796:LOC100071602
gene id: 9796:LOC100071602
uniprot id: A0A3Q2GZ02
names: Similarity
messages: Belongs to the FAM228 family.

9796:LOC100068986
gene id: 9796:LOC100068986
uniprot id: F6TTF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CALR
gene id: 9796:CALR
uniprot id: F6TQR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen
messages: Monomer.

9796:ZKSCAN1
gene id: 9796:ZKSCAN1
uniprot id: F6RYN5
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100053065
gene id: 9796:LOC100053065
uniprot id: F6Y7V5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:CD79A
gene id: 9796:CD79A
uniprot id: F7CGN8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:BCAN
gene id: 9796:BCAN
uniprot id: F6PNK4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9796:C7H11orf54
gene id: 9796:C7H11orf54
uniprot id: F7DS10
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9796:LOC100054424
gene id: 9796:LOC100054424
uniprot id: A0A3Q2LL46
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:LOC100053499
gene id: 9796:LOC100053499
uniprot id: A0A3Q2HBF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:TPX2
gene id: 9796:TPX2
uniprot id: F7A3W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

9796:LOC100063274
gene id: 9796:LOC100063274
uniprot id: A0A3Q2GUU9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:OAS3
gene id: 9796:OAS3
uniprot id: Q5J0M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9796:KEF40 p04
gene id: 9796:KEF40_p04
uniprot id: P48655
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9796:HBA2
gene id: 9796:HBA2
uniprot id: Q28383
names: Similarity
messages: Belongs to the globin family.

9796:TLL1
gene id: 9796:TLL1
uniprot id: F7A5S8
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:CDKN3
gene id: 9796:CDKN3
uniprot id: A0A3Q2HM40
uniprot id: F6VTZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9796:LOC100056527
gene id: 9796:LOC100056527
uniprot id: F6Z3N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100053545
gene id: 9796:LOC100053545
uniprot id: A0A3Q2LFW2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:TMEM14A
gene id: 9796:TMEM14A
uniprot id: F6TLS2
names: Similarity
messages: Belongs to the TMEM14 family.

9796:DCP2
gene id: 9796:DCP2
uniprot id: A0A3Q2HW60
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9796:LOC100053105
gene id: 9796:LOC100053105
uniprot id: F6XYG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:NUP50
gene id: 9796:NUP50
uniprot id: F6XDP3
names: Subcellular Location Annotation
messages: nuclear pore complex

9796:DDX47
gene id: 9796:DDX47
uniprot id: A0A3Q2KQR1
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9796:CWF19L1
gene id: 9796:CWF19L1
uniprot id: A0A3Q2HBD0
uniprot id: F6X7E1
names: Similarity
messages: Belongs to the CWF19 family.

9796:MEF2A
gene id: 9796:MEF2A
uniprot id: A0A090AMY7
names: Subcellular Location Annotation
messages: Nucleus

9796:ENSA
gene id: 9796:ENSA
uniprot id: F6WVJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9796:LOC100054307
gene id: 9796:LOC100054307
uniprot id: F6YIN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:IMPDH2
gene id: 9796:IMPDH2
uniprot id: F7BT61
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9796:ITGA3
gene id: 9796:ITGA3
uniprot id: F6W8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9796:LPAR4
gene id: 9796:LPAR4
uniprot id: A0A5F5PVC0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:HTR2C
gene id: 9796:HTR2C
uniprot id: F6PSU6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MPDZ. Interacts with ARRB2.
messages: Membrane

9796:SLC35B1
gene id: 9796:SLC35B1
uniprot id: F6Y9G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9796:SPA17
gene id: 9796:SPA17
uniprot id: F6U860
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9796:FAM135B
gene id: 9796:FAM135B
uniprot id: F6ZLZ7
names: Similarity
messages: Belongs to the FAM135 family.

9796:MAEL
gene id: 9796:MAEL
uniprot id: F7DRD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9796:TRIM45
gene id: 9796:TRIM45
uniprot id: F6RUP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9796:GFOD2
gene id: 9796:GFOD2
uniprot id: F7DQN1
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9796:RORB
gene id: 9796:RORB
uniprot id: F6XEI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9796:NLK
gene id: 9796:NLK
uniprot id: F6Q5M6
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9796:SNRPD3
gene id: 9796:SNRPD3
uniprot id: F6TZ46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9796:METTL3
gene id: 9796:METTL3
uniprot id: F7BJ96
names: Similarity
messages: Belongs to the MT-A70-like family.

9796:LOC100065031
gene id: 9796:LOC100065031
uniprot id: F6YXJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9796:KIF3B
gene id: 9796:KIF3B
uniprot id: F7CYC1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:MPV17
gene id: 9796:MPV17
uniprot id: A0A3Q2H0W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9796:TLR4
gene id: 9796:TLR4
uniprot id: Q9MYW3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with MAP3K21; this interaction leads to negative regulation of TLR4 signaling. Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR6. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Interacts with TICAM1 in response to LPS in a WDFY1-dependent manner. Interacts with WDFY1 in response to LPS. Interacts with SMPDL3B. Interacts with CEACAM1; upon lipopolysaccharide stimulation, forms a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Interacts with RFTN1; the interaction occurs in response to lipopolysaccharide stimulation. Interacts with SCIMP; the interaction occurs in response to lipopolysaccharide stimulation and is enhanced by phosphorylation of SCIMP by LYN (By similarity). This interaction facilitates the phosphorylation of TLR4 by LYN which elicits a selective cytokine response in macrophages (By similarity). Interacts with TRAF3IP3 (By similarity). Interacts with TREM1; this interaction enhances TLR4-mediated inflammatory response (By similarity).
messages: Cell membrane
messages: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity). Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation (By similarity).
messages: Early endosome
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Phosphorylated on tyrosine residues by LYN after binding lipopolysaccharide.
messages: The TIR domain mediates interaction with NOX4.
messages: ruffle

9796:LYVE1
gene id: 9796:LYVE1
uniprot id: F6S568
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:RGS8
gene id: 9796:RGS8
uniprot id: A0A3Q2H2B8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: Perikaryon
messages: dendrite

9796:IL2RB
gene id: 9796:IL2RB
uniprot id: F6V1A3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.

9796:TCEAL1
gene id: 9796:TCEAL1
uniprot id: F6U3Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: Nucleus

9796:RAD50
gene id: 9796:RAD50
uniprot id: F7AR56
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9796:TGM2
gene id: 9796:TGM2
uniprot id: F7DA17
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9796:WDR45
gene id: 9796:WDR45
uniprot id: A0A5F5PF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure

9796:KRT83
gene id: 9796:KRT83
uniprot id: F6T2K0
names: Similarity
messages: Belongs to the intermediate filament family.

9796:LOC100063021
gene id: 9796:LOC100063021
uniprot id: A0A3Q2KJ33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:BORCS8
gene id: 9796:BORCS8
uniprot id: F7BZK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9796:IQCD
gene id: 9796:IQCD
uniprot id: F6X5C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9796:P19
gene id: 9796:P19
uniprot id: Q28388
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Binds fatty acids and retinol. Is specialized for the preattachment embryo. May be important to maintain the pregnancy and may transport small hydrophobic ligands from mother to the developing embryo.
messages: Expressed in glandular and lumenal epithelia of the endometrium. Is transferred to the embryonic capsule, the conceptus and the yolk sac.
messages: Secreted

9796:LOC106782337
gene id: 9796:LOC106782337
uniprot id: A0A5F5Q0Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MRPL12
gene id: 9796:MRPL12
uniprot id: F6XAD7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9796:PROX1
gene id: 9796:PROX1
uniprot id: F7A7U8
names: Subcellular Location Annotation
messages: Nucleus

9796:NDC80
gene id: 9796:NDC80
uniprot id: F6XIY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9796:PLD5
gene id: 9796:PLD5
uniprot id: F6VYJ3
names: Similarity
messages: Belongs to the phospholipase D family.

9796:APCS
gene id: 9796:APCS
uniprot id: F7C349
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9796:LOC100055584
gene id: 9796:LOC100055584
uniprot id: F6ULU9
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9796:FGF23
gene id: 9796:FGF23
uniprot id: A0A7U3L5L0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9796:HS6ST2
gene id: 9796:HS6ST2
uniprot id: A0A5F5Q1U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9796:LOC102148675
gene id: 9796:LOC102148675
uniprot id: A0A3Q2I6Q5
uniprot id: A0A5F5PWL0
names: Similarity
messages: Belongs to the NXPE family.

9796:LOC102151065
gene id: 9796:LOC102151065
uniprot id: F7B1B5
names: Subcellular Location Annotation
messages: Nucleus

9796:AMELX
gene id: 9796:AMELX
uniprot id: F6QHS4
names: Similarity
messages: Belongs to the amelogenin family.

9796:SRP9
gene id: 9796:SRP9
uniprot id: A0A3Q2GWW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9796:KCNMB2
gene id: 9796:KCNMB2
uniprot id: A0A3Q2I792
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9796:MYO10
gene id: 9796:MYO10
uniprot id: F6TKJ8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9796:BCAR1
gene id: 9796:BCAR1
uniprot id: A0A3Q2LGL0
uniprot id: F7C5Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9796:TMEM256
gene id: 9796:TMEM256
uniprot id: F7DUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9796:MED4
gene id: 9796:MED4
uniprot id: F6YFK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9796:CSN1S1
gene id: 9796:CSN1S1
uniprot id: Q8SPR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Secreted

9796:RAF1
gene id: 9796:RAF1
uniprot id: F6QHE2
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9796:PAQR8
gene id: 9796:PAQR8
uniprot id: F6SKF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9796:MOSPD1
gene id: 9796:MOSPD1
uniprot id: A0A3Q2HTM4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

9796:TACC3
gene id: 9796:TACC3
uniprot id: F7AEJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9796:TMEM59
gene id: 9796:TMEM59
uniprot id: F7E288
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:YPEL5
gene id: 9796:YPEL5
uniprot id: K9KBL9
names: Similarity
messages: Belongs to the yippee family.

9796:RPL29
gene id: 9796:RPL29
uniprot id: F7DCZ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9796:SEPT9
gene id: 9796:SEPT9
uniprot id: A0A5F5PR46
uniprot id: F6W0T6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9796:PIK3R1
gene id: 9796:PIK3R1
uniprot id: A0A3Q2LU84
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9796:RFFL
gene id: 9796:RFFL
uniprot id: A0A3Q2KVL8
names: Subcellular Location Annotation
messages: Cell membrane

9796:MFAP1
gene id: 9796:MFAP1
uniprot id: F7BNW9
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9796:MARS
gene id: 9796:MARS
uniprot id: A0A3Q2HZ28
uniprot id: A0A3Q2I5M6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9796:LOC100064551
gene id: 9796:LOC100064551
uniprot id: A0A7R8C3T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:SERPINB7
gene id: 9796:SERPINB7
uniprot id: A0A3Q2KMP9
names: Similarity
messages: Belongs to the serpin family.

9796:POLR3G
gene id: 9796:POLR3G
uniprot id: F6QYU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

9796:CRABP2
gene id: 9796:CRABP2
uniprot id: F6XR54
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9796:LOC100629180
gene id: 9796:LOC100629180
uniprot id: A0A3Q2IDV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9796:TCN1
gene id: 9796:TCN1
uniprot id: F6T7K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9796:SVOPL
gene id: 9796:SVOPL
uniprot id: F7DQV6
names: Subcellular Location Annotation
messages: Membrane

9796:B3GNT2
gene id: 9796:B3GNT2
uniprot id: F6XBJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:LOC100070087
gene id: 9796:LOC100070087
uniprot id: A0A3Q2HNU3
names: Caution
names: Similarity
messages: Belongs to the seminal plasma protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:CAP2
gene id: 9796:CAP2
uniprot id: F6VEI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane

9796:PROKR2
gene id: 9796:PROKR2
uniprot id: A0A3Q2HF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9796:BIRC3
gene id: 9796:BIRC3
uniprot id: F6SJV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9796:DBH
gene id: 9796:DBH
uniprot id: F7E2E6
uniprot id: Q9XTA0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Conversion of dopamine to noradrenaline.
messages: Detected in adrenal medulla chromaffin cells.
messages: Homotetramer; composed of two disulfide-linked dimers.
messages: N-glycosylated.
messages: Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.
messages: Secreted
messages: chromaffin granule lumen
messages: chromaffin granule membrane
messages: secretory vesicle lumen
messages: secretory vesicle membrane

9796:APOD
gene id: 9796:APOD
uniprot id: F6XM13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9796:HOGA1
gene id: 9796:HOGA1
uniprot id: F6RPW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9796:CFAP52
gene id: 9796:CFAP52
uniprot id: F6SKR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP52 family.
messages: cilium axoneme
messages: flagellum

9796:NFU1
gene id: 9796:NFU1
uniprot id: F6QV87
names: Similarity
messages: Belongs to the NifU family.

9796:PDC
gene id: 9796:PDC
uniprot id: Q9XS39
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosducin family.
messages: Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with CRX (By similarity).
messages: Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.
messages: May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity).
messages: Nucleus
messages: Photoreceptor inner segment
messages: cytosol
messages: photoreceptor outer segment

9796:THBS2
gene id: 9796:THBS2
uniprot id: F6Y5R3
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:MRPS18B
gene id: 9796:MRPS18B
uniprot id: F6ZJX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

9796:GPHB5
gene id: 9796:GPHB5
uniprot id: F6S8D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9796:CCNT2
gene id: 9796:CCNT2
uniprot id: A0A3Q2HM65
uniprot id: A0A3Q2I916
names: Similarity
messages: Belongs to the cyclin family.

9796:TAS1R3
gene id: 9796:TAS1R3
uniprot id: F7BK68
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:TAF7L
gene id: 9796:TAF7L
uniprot id: F7DGK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9796:LOC100056234
gene id: 9796:LOC100056234
uniprot id: F6PS74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RAB4A
gene id: 9796:RAB4A
uniprot id: F6S7B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9796:PPP6C
gene id: 9796:PPP6C
uniprot id: F6VRC2
names: Similarity
messages: Belongs to the PPP phosphatase family.

9796:RPF1
gene id: 9796:RPF1
uniprot id: F7CBY3
uniprot id: L7MS55
names: Subcellular Location Annotation
messages: nucleolus

9796:SPIC
gene id: 9796:SPIC
uniprot id: F6XL56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:LOC100062476
gene id: 9796:LOC100062476
uniprot id: A0A3Q2HKZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PIP4P2
gene id: 9796:PIP4P2
uniprot id: F6TE00
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9796:STAB1
gene id: 9796:STAB1
uniprot id: F7C1Y3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:FGF1
gene id: 9796:FGF1
uniprot id: F6WDN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9796:HSP90AB1
gene id: 9796:HSP90AB1
uniprot id: Q9GKX8
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cell membrane
messages: Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: ISGylated.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Melanosome
messages: Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylatio…
messages: Monomer. Homodimer (By similarity). Forms a complex with CDK6 and CDC37. Interacts with UNC45A; binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity). Interacts with CHORDC1 (By similarity). Interacts with DNAJC7. Interacts with FKBP4. May interact with NWD1. Interacts with SGTA. Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with STUB1 and SMAD3. Interacts with XPO1 and AHSA1. Interacts with BIRC2. Interacts with KCNQ4; promotes cell surface expression of KCNQ4. Interacts with BIRC2; prevents auto-ubiquitination and degradation of its client protein BIRC2. Interacts with NOS3. Interacts with AHR; interaction is inhibited by HSP90AB1 phosphorylation on Ser-226 and Ser-255. Interacts with STIP1 and CDC37; upon SMYD2-dependent methylation. Interacts with JAK2 and PRKCE; promotes functional activation in a heat shock-dependent manner. Interacts with HSP90AA1; interaction is constitutive. HSP90AB1-CDC37 chaperone complex interacts with inactive MAPK7 (via N-terminal half) in resting cells; the interaction is MAP2K5-independent and prevents from ubiquitination and proteasomal degradation. Interacts with CDC25A; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression. Interacts with TP53 (via DNA binding domain); suppresses TP53 aggregation and prevents from irreversible thermal inactivation. Interacts with TGFB1 processed form (LAP); inhibits latent TGFB1 activation (By similarity). Interacts with TRIM8; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1 (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with TTC4 (via TPR repeats) (By similarity). Interacts with IL1B; the interaction facilitates cargo translocation i…
messages: Nucleus
messages: Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide. Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction.
messages: S-nitrosylated; negatively regulates the ATPase activity.
messages: Secreted
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
messages: Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).

9796:ENTPD8
gene id: 9796:ENTPD8
uniprot id: A0A5F5Q2L5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9796:TMCC3
gene id: 9796:TMCC3
uniprot id: F7AJN5
names: Similarity
messages: Belongs to the TEX28 family.

9796:DAPK2
gene id: 9796:DAPK2
uniprot id: A0A3Q2HPG2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:NLRP14
gene id: 9796:NLRP14
uniprot id: A0A3Q2H3B9
names: Similarity
messages: Belongs to the NLRP family.

9796:SLC10A1
gene id: 9796:SLC10A1
uniprot id: F7CX89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9796:DDX31
gene id: 9796:DDX31
uniprot id: A0A3Q2H7X3
names: Similarity
messages: Belongs to the DEAD box helicase family.

9796:MFSD8
gene id: 9796:MFSD8
uniprot id: F7CKS2
names: Subcellular Location Annotation
messages: Membrane

9796:NFYA
gene id: 9796:NFYA
uniprot id: A0A3Q2HSB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9796:RNF141
gene id: 9796:RNF141
uniprot id: F6W815
names: Function
messages: May be involved in spermatogenesis.

9796:CLCC1
gene id: 9796:CLCC1
uniprot id: F7BIM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

9796:ARL3
gene id: 9796:ARL3
uniprot id: F7DNM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9796:EVA1A
gene id: 9796:EVA1A
uniprot id: A0A3Q2LL98
names: Similarity
messages: Belongs to the EVA1 family.

9796:PON3
gene id: 9796:PON3
uniprot id: F7BR80
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9796:TMX2
gene id: 9796:TMX2
uniprot id: F7DNF2
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9796:PXN
gene id: 9796:PXN
uniprot id: F7D2Z3
names: Subcellular Location Annotation
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

9796:LOC100630794
gene id: 9796:LOC100630794
uniprot id: F7DM22
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9796:RPS29
gene id: 9796:RPS29
uniprot id: F7AJL6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9796:PLA2G15
gene id: 9796:PLA2G15
uniprot id: F7C6I3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9796:C1H10orf53
gene id: 9796:C1H10orf53
uniprot id: F6T880
names: Similarity
messages: Belongs to the UPF0728 family.

9796:CAV2
gene id: 9796:CAV2
uniprot id: Q2QLB1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
messages: Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).
messages: caveola

9796:GPR37L1
gene id: 9796:GPR37L1
uniprot id: F7BKR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9796:E2F7
gene id: 9796:E2F7
uniprot id: A0A3Q2HG98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9796:IFND1
gene id: 9796:IFND1
uniprot id: B6CGU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:LAMP3
gene id: 9796:LAMP3
uniprot id: A0A3Q2I8B7
uniprot id: F6V455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9796:HOXA5
gene id: 9796:HOXA5
uniprot id: F7DK44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9796:GPR83
gene id: 9796:GPR83
uniprot id: F6VZL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9796:TAF13
gene id: 9796:TAF13
uniprot id: F7ADE8
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100068309
gene id: 9796:LOC100068309
uniprot id: F6UPC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HACD3
gene id: 9796:HACD3
uniprot id: F6VAN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:NDUFAF1
gene id: 9796:NDUFAF1
uniprot id: F6R7D5
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9796:LOC100072608
gene id: 9796:LOC100072608
uniprot id: A0A3Q2GZQ0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:B4GALT7
gene id: 9796:B4GALT7
uniprot id: A0A3Q2HPQ5
uniprot id: F7BBC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9796:MYOZ3
gene id: 9796:MYOZ3
uniprot id: F7CA91
names: Similarity
messages: Belongs to the myozenin family.

9796:NECAP1
gene id: 9796:NECAP1
uniprot id: F6T0N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9796:KRTCAP3
gene id: 9796:KRTCAP3
uniprot id: F6SCX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9796:LOC100055155
gene id: 9796:LOC100055155
uniprot id: F6YKD5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:MCM7
gene id: 9796:MCM7
uniprot id: F7C432
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9796:ATP5F1C
gene id: 9796:ATP5F1C
uniprot id: A0A3Q2HP00
uniprot id: F6SJM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9796:CRY1
gene id: 9796:CRY1
uniprot id: F6VMD8
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9796:SPI1
gene id: 9796:SPI1
uniprot id: F6YVX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:PTS
gene id: 9796:PTS
uniprot id: F6VDI5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9796:GRHL2
gene id: 9796:GRHL2
uniprot id: F7BG04
names: Subcellular Location Annotation
messages: Nucleus

9796:CDSN
gene id: 9796:CDSN
uniprot id: A0A3Q2GWT4
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9796:ATP5F1B
gene id: 9796:ATP5F1B
uniprot id: F6U187
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9796:ASB8
gene id: 9796:ASB8
uniprot id: F6YTT0
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9796:VPS4B
gene id: 9796:VPS4B
uniprot id: F7A7E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9796:TRIM67
gene id: 9796:TRIM67
uniprot id: F7CR77
names: Subcellular Location Annotation
messages: cytoskeleton

9796:NDUFA8
gene id: 9796:NDUFA8
uniprot id: F6UMV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9796:ESF1
gene id: 9796:ESF1
uniprot id: F7BLB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9796:CXCL16
gene id: 9796:CXCL16
uniprot id: F7CTX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Membrane

9796:PHACTR4
gene id: 9796:PHACTR4
uniprot id: A0A3Q2HII2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

9796:LOC102149028
gene id: 9796:LOC102149028
uniprot id: A0A3Q2HM80
names: Similarity
messages: Belongs to the serpin family.

9796:HSPB6
gene id: 9796:HSPB6
uniprot id: A0A3Q2HPI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9796:VGLL4
gene id: 9796:VGLL4
uniprot id: A0A3Q2HVT8
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9796:CHRNA6
gene id: 9796:CHRNA6
uniprot id: F7DKD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:SNF8
gene id: 9796:SNF8
uniprot id: F6Z295
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

9796:GSN
gene id: 9796:GSN
uniprot id: Q28372
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the villin/gelsolin family.
messages: Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X (By similarity). Interacts with the inactive form of EIF2AK2/PKR (By similarity).
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity).
messages: Comprises six structurally related gelsolin-like (G1-G6) domains, that, in a calcium-free environment, are packed together to form a compact globular structure in which the putative actin-binding sequences are not sufficiently exposed to enable binding to occur. Binding calcium may release the connections that join the N- and C-terminal halves of gelsolin, enabling each half to bind actin relatively independently. G1 and G4 bind two Ca(2+) in a type I and in a type II manner. G2, G3, G5 and G6 bind only one Ca(2+) in a type II manner. Type I Ca(2+) binding sites are shared between actin and gelsolin-like repeats G1 and G4. Type I binding governs the strength of interactions between gelsolin and actin by direct participation at the binding interface. Ca(2+) binding to G2 and G6 disrupts the interactions between G2 and G6, releases the C-terminal tail, and induces large interdomain rearrangements that result in the exposure of the F-actin-binding site on G2 and contributes to the activation of gelsolin. Binding to phosphoinositides may inhibit the severing and capping properties of gelsolin.
messages: cytoskeleton

9796:TM4SF1
gene id: 9796:TM4SF1
uniprot id: F7A891
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9796:ST7
gene id: 9796:ST7
uniprot id: A0A5K1VEG5
uniprot id: Q2QLA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9796:FUT10
gene id: 9796:FUT10
uniprot id: F7DBI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9796:ACKR1
gene id: 9796:ACKR1
uniprot id: F7DSK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

9796:NMUR1
gene id: 9796:NMUR1
uniprot id: F6SBE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9796:PPP1R11
gene id: 9796:PPP1R11
uniprot id: F7CUN1
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9796:BCAS2
gene id: 9796:BCAS2
uniprot id: F6TRS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

9796:CXHXorf36
gene id: 9796:CXHXorf36
uniprot id: F6XDM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9796:ADGRF5
gene id: 9796:ADGRF5
uniprot id: A0A3Q2H3S5
uniprot id: A0A3Q2LAQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9796:SPDL1
gene id: 9796:SPDL1
uniprot id: A0A3Q2I437
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9796:ALDH3B1
gene id: 9796:ALDH3B1
uniprot id: A0A3Q2HS50
uniprot id: F6TZ61
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9796:LOC100073114
gene id: 9796:LOC100073114
uniprot id: F7A5C0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:TGFA
gene id: 9796:TGFA
uniprot id: A0A3Q2HTA3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:NDUFS2
gene id: 9796:NDUFS2
uniprot id: F6XJY4
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

9796:GJA3
gene id: 9796:GJA3
uniprot id: F6U7L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:CKS1B
gene id: 9796:CKS1B
uniprot id: A0A3Q2HEZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9796:JAK2
gene id: 9796:JAK2
uniprot id: F6RE38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system
messages: Nucleus

9796:ATP6V1G3
gene id: 9796:ATP6V1G3
uniprot id: F6Y1M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9796:AQP2
gene id: 9796:AQP2
uniprot id: F6YNH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9796:TGM3
gene id: 9796:TGM3
uniprot id: F6YMM5
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9796:SLC25A39
gene id: 9796:SLC25A39
uniprot id: A0A3Q2IHW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9796:SFTPA1
gene id: 9796:SFTPA1
uniprot id: Q95L88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPA family.
messages: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
messages: Oligomeric complex of 6 set of homotrimers.
messages: Secreted
messages: extracellular matrix
messages: surface film

9796:BMP4
gene id: 9796:BMP4
uniprot id: F6QG82
names: Similarity
messages: Belongs to the TGF-beta family.

9796:SAP18
gene id: 9796:SAP18
uniprot id: F7AC40
names: Similarity
messages: Belongs to the SAP18 family.

9796:HIBADH
gene id: 9796:HIBADH
uniprot id: F6XXT9
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9796:LOC100146266
gene id: 9796:LOC100146266
uniprot id: A0A5F5PY49
names: Similarity
messages: Belongs to the FAM122 family.

9796:DXO
gene id: 9796:DXO
uniprot id: F7CGF5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9796:HSBP1
gene id: 9796:HSBP1
uniprot id: F6PV50
names: Similarity
messages: Belongs to the HSBP1 family.

9796:DCST1
gene id: 9796:DCST1
uniprot id: F7BVV7
names: Subcellular Location Annotation
messages: Membrane

9796:TM4SF5
gene id: 9796:TM4SF5
uniprot id: F6YH60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9796:PTTG1
gene id: 9796:PTTG1
uniprot id: F6XRS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9796:ETV1
gene id: 9796:ETV1
uniprot id: A0A3Q2HST5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9796:LOC100059285
gene id: 9796:LOC100059285
uniprot id: F6ZSB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9796:NDUFB1
gene id: 9796:NDUFB1
uniprot id: F6XJG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9796:DCPS
gene id: 9796:DCPS
uniprot id: F6RH25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9796:AASDH
gene id: 9796:AASDH
uniprot id: F6Z0S7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9796:GCG
gene id: 9796:GCG
uniprot id: F7ABP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9796:NCBP2
gene id: 9796:NCBP2
uniprot id: F6WBD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9796:LOC100056932
gene id: 9796:LOC100056932
uniprot id: F6TVW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:STAR
gene id: 9796:STAR
uniprot id: F6Q5N5
uniprot id: O46689
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9796:FYTTD1
gene id: 9796:FYTTD1
uniprot id: F7B5A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

9796:NEU1
gene id: 9796:NEU1
uniprot id: F6V6F7
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9796:ZNF24
gene id: 9796:ZNF24
uniprot id: F7CRC8
names: Subcellular Location Annotation
messages: Nucleus

9796:CXCR2
gene id: 9796:CXCR2
uniprot id: F7ACE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:NUBPL
gene id: 9796:NUBPL
uniprot id: F6XC81
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9796:PLRG1
gene id: 9796:PLRG1
uniprot id: A0A3Q2I9L3
uniprot id: K9K2C7
uniprot id: L7MSE9
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9796:NDUFA7
gene id: 9796:NDUFA7
uniprot id: F7DSQ7
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9796:ALG14
gene id: 9796:ALG14
uniprot id: F7CFM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Membrane
messages: Nucleus membrane

9796:CRABP1
gene id: 9796:CRABP1
uniprot id: A0A3Q2HZJ8
names: Function
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

9796:PAM16
gene id: 9796:PAM16
uniprot id: F7BKR4
names: Similarity
messages: Belongs to the TIM16/PAM16 family.

9796:ADCY9
gene id: 9796:ADCY9
uniprot id: F6XFB9
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9796:SERPINB1
gene id: 9796:SERPINB1
uniprot id: P05619
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: Cytolytic granule
messages: Cytoplasm
messages: Early endosome
messages: Monomer. Interacts (via C-terminus) with CASP1; CASP4 (via CARD domain) and CASP5; these interactions regulate the activity of inflammatory caspases. Interacts with PRTN3. Interacts with GZMH (By similarity). Interacts with TMSB4 (PubMed:1551869).
messages: Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function.
messages: Secreted
messages: The N-terminus is blocked.

9796:CNTNAP1
gene id: 9796:CNTNAP1
uniprot id: F6X9P2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9796:REV1
gene id: 9796:REV1
uniprot id: F6T4C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

9796:TAP2
gene id: 9796:TAP2
uniprot id: F7DH87
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9796:LOC100059324
gene id: 9796:LOC100059324
uniprot id: A0A3Q2HP21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:EQUCABV1R907
gene id: 9796:EQUCABV1R907
uniprot id: A0A3Q2H2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:LOC100055686
gene id: 9796:LOC100055686
uniprot id: F7E326
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ARF5
gene id: 9796:ARF5
uniprot id: A0A5F5PFZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9796:MMRN1
gene id: 9796:MMRN1
uniprot id: F7A1S2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:LOC100147577
gene id: 9796:LOC100147577
uniprot id: A0A3Q2GTS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CXCL6
gene id: 9796:CXCL6
uniprot id: F6S9Z1
uniprot id: K9KDT0
uniprot id: Q8MIN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity).
messages: Secreted

9796:RPL26
gene id: 9796:RPL26
uniprot id: F6TSK0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9796:PFKM
gene id: 9796:PFKM
uniprot id: Q867C9
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: GlcNAcylation decreases enzyme activity.
messages: Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (M), PFKL (L) and PFKP (P). The composition of the PFK tetramer differs according to the tissue type it is present in. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable). Interacts (via C-terminus) with HK1 (via N-terminal spermatogenic cell-specific region) (By similarity).

9796:KIF1BP
gene id: 9796:KIF1BP
uniprot id: F7D3N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

9796:NUCB2
gene id: 9796:NUCB2
uniprot id: F6Y426
names: Similarity
messages: Belongs to the nucleobindin family.

9796:LOC100053263
gene id: 9796:LOC100053263
uniprot id: F6WPA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:IL2RA
gene id: 9796:IL2RA
uniprot id: A8VUE0
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9796:NAXE
gene id: 9796:NAXE
uniprot id: A0A3Q2LNW9
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
messages: Homodimer. Interacts with APOA1 and APOA2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

9796:GTF2B
gene id: 9796:GTF2B
uniprot id: F6PJP4
names: Similarity
messages: Belongs to the TFIIB family.

9796:CDH15
gene id: 9796:CDH15
uniprot id: F6WEI6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9796:LYG1
gene id: 9796:LYG1
uniprot id: F6TJC3
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9796:USE1
gene id: 9796:USE1
uniprot id: F7A5U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:FOXP3
gene id: 9796:FOXP3
uniprot id: B2CXY8
names: Subcellular Location Annotation
messages: Nucleus

9796:MTNR1A
gene id: 9796:MTNR1A
uniprot id: F7CZB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9796:AXIN1
gene id: 9796:AXIN1
uniprot id: A0A3Q2GWD2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9796:INTS2
gene id: 9796:INTS2
uniprot id: F6U3W7
names: Similarity
messages: Belongs to the Integrator subunit 2 family.

9796:PATZ1
gene id: 9796:PATZ1
uniprot id: A0A3Q2H1L1
uniprot id: A0A3Q2L0R5
uniprot id: A0A3Q2LPV0
names: Subcellular Location Annotation
messages: Nucleus

9796:CASKIN2
gene id: 9796:CASKIN2
uniprot id: A0A3Q2LT24
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9796:ITGB3
gene id: 9796:ITGB3
uniprot id: Q52MQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9796:IL2
gene id: 9796:IL2
uniprot id: B1AB81
uniprot id: P37997
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9796:HPF1
gene id: 9796:HPF1
uniprot id: A0A3Q2H0A2
uniprot id: F7ARE5
names: Similarity
messages: Belongs to the HPF1 family.

9796:LOC100071922
gene id: 9796:LOC100071922
uniprot id: F6XQE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100629732
gene id: 9796:LOC100629732
uniprot id: A0A3Q2I5A8
names: Similarity
messages: Belongs to the KRTAP type 3 family.

9796:CCL26
gene id: 9796:CCL26
uniprot id: F6ZD18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9796:VPS28
gene id: 9796:VPS28
uniprot id: F6UHG8
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

9796:RGS3
gene id: 9796:RGS3
uniprot id: A0A3Q2KWB2
names: Subcellular Location Annotation
messages: Cytoplasm

9796:TIGD7
gene id: 9796:TIGD7
uniprot id: F7AI66
names: Subcellular Location Annotation
messages: Nucleus

9796:CCL28
gene id: 9796:CCL28
uniprot id: F6VWX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9796:COG2
gene id: 9796:COG2
uniprot id: F6SW28
names: Similarity
messages: Belongs to the COG2 family.

9796:TOX4
gene id: 9796:TOX4
uniprot id: A0A5F5PN64
names: Subcellular Location Annotation
messages: Nucleus

9796:GJA8
gene id: 9796:GJA8
uniprot id: F6VG96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:CLRN1
gene id: 9796:CLRN1
uniprot id: F7C0R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9796:TMEM45B
gene id: 9796:TMEM45B
uniprot id: F7D765
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9796:GPN2
gene id: 9796:GPN2
uniprot id: A0A5F5PF78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9796:LOC100070809
gene id: 9796:LOC100070809
uniprot id: F6TEF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100072408
gene id: 9796:LOC100072408
uniprot id: F7D758
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CRYGS
gene id: 9796:CRYGS
uniprot id: F7DV62
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9796:FGD3
gene id: 9796:FGD3
uniprot id: F6V8R8
names: Subcellular Location Annotation
messages: cytoskeleton

9796:LOC100064281
gene id: 9796:LOC100064281
uniprot id: F7D7N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9796:ODF2L
gene id: 9796:ODF2L
uniprot id: F6X8M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9796:LNPK
gene id: 9796:LNPK
uniprot id: A0A3Q2HTJ9
uniprot id: F6WGZ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9796:EEF1A1
gene id: 9796:EEF1A1
uniprot id: A2Q0Z0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1 and TXK. Interacts with KARS1. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner (By similarity). Interacts with PPP1R16B (By similarity). Interacts with SPHK1 and SPHK2; both interactions increase SPHK1 and SPHK2 kinase activity (By similarity).
messages: ISGylated.
messages: Nucleus
messages: Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.
messages: Trimethylated at Lys-79 by EEF1AKMT1. Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. Trimethylated at Lys-318 by EEF1AKMT2. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs. Trimethylated at Gly-2 by METTL13. Mono- and dimethylated at Lys-55 by METTL13; dimethylated form is predominant.
messages: nucleolus

9796:ATP2A2
gene id: 9796:ATP2A2
uniprot id: Q257U4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9796:S100A7
gene id: 9796:S100A7
uniprot id: Q14ST5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Interacts with RANBP9.
messages: Secreted

9796:LHFPL1
gene id: 9796:LHFPL1
uniprot id: F6TUC7
names: Subcellular Location Annotation
messages: Membrane

9796:LOC102148684
gene id: 9796:LOC102148684
uniprot id: F6WTH5
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100065083
gene id: 9796:LOC100065083
uniprot id: F6TLM4
names: Subcellular Location Annotation
messages: Membrane

9796:DHX9
gene id: 9796:DHX9
uniprot id: F6UTW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9796:CDH3
gene id: 9796:CDH3
uniprot id: F6Z621
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9796:LOC100054164
gene id: 9796:LOC100054164
uniprot id: A0A3Q2IAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:CLCN5
gene id: 9796:CLCN5
uniprot id: F7BAS5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:LOC100070697
gene id: 9796:LOC100070697
uniprot id: F6SP48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TFAP2A
gene id: 9796:TFAP2A
uniprot id: A0A3Q2HWL7
uniprot id: F6RW70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9796:LYRM1
gene id: 9796:LYRM1
uniprot id: F6PVS5
names: Similarity
messages: Belongs to the complex I LYR family.

9796:PSMD12
gene id: 9796:PSMD12
uniprot id: F6PY78
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9796:LOXL4
gene id: 9796:LOXL4
uniprot id: F7ADD3
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9796:LOC100054250
gene id: 9796:LOC100054250
uniprot id: F6TUS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NOX3
gene id: 9796:NOX3
uniprot id: F6RG72
names: Subcellular Location Annotation
messages: Membrane

9796:FGFR1OP2
gene id: 9796:FGFR1OP2
uniprot id: A0A5F5PXJ9
names: Similarity
messages: Belongs to the SIKE family.

9796:TMEM144
gene id: 9796:TMEM144
uniprot id: A0A3Q2HLD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9796:POLG
gene id: 9796:POLG
uniprot id: F6VI74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

9796:ARL1
gene id: 9796:ARL1
uniprot id: F7D482
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9796:LOC102148609
gene id: 9796:LOC102148609
uniprot id: A0A5F5Q2N8
names: Similarity
messages: Belongs to the LCE family.

9796:GPR183
gene id: 9796:GPR183
uniprot id: F6VPM1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:WDR12
gene id: 9796:WDR12
uniprot id: F6YTI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9796:DNASE1
gene id: 9796:DNASE1
uniprot id: Q4AEE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Divalent metal cations. Prefers Ca(2+) or Mg(2+).
messages: Nucleus envelope
messages: Secreted
messages: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (By similarity). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
messages: Zymogen granule

9796:LEAP2
gene id: 9796:LEAP2
uniprot id: A0A3Q2LBF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9796:CLDN17
gene id: 9796:CLDN17
uniprot id: F6VLZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9796:LOC100053156
gene id: 9796:LOC100053156
uniprot id: F7AHT9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:CA8
gene id: 9796:CA8
uniprot id: F6QJF7
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9796:EML4
gene id: 9796:EML4
uniprot id: A0A3Q2I1I5
uniprot id: F6T5V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9796:LOC100058936
gene id: 9796:LOC100058936
uniprot id: A0A3Q2GW09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100067739
gene id: 9796:LOC100067739
uniprot id: F6ZEP5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9796:LOC100066391
gene id: 9796:LOC100066391
uniprot id: F7DVU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100072368
gene id: 9796:LOC100072368
uniprot id: F6W6S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GNRHR
gene id: 9796:GNRHR
uniprot id: O18821
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

9796:EPN1
gene id: 9796:EPN1
uniprot id: A0A5F5PNH6
uniprot id: F6TQ05
names: Similarity
messages: Belongs to the epsin family.

9796:ZSCAN30
gene id: 9796:ZSCAN30
uniprot id: F6PLA5
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100062565
gene id: 9796:LOC100062565
uniprot id: F6PYG6
names: Similarity
messages: Belongs to the FAH family.

9796:LOC100058108
gene id: 9796:LOC100058108
uniprot id: F7CM10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SRSF5
gene id: 9796:SRSF5
uniprot id: A0A3Q2LA32
names: Similarity
messages: Belongs to the splicing factor SR family.

9796:NME7
gene id: 9796:NME7
uniprot id: K9K275
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9796:LOC102149887
gene id: 9796:LOC102149887
uniprot id: A0A3Q2H5Q6
names: Similarity
messages: Belongs to the PPDPF family.

9796:TCP1
gene id: 9796:TCP1
uniprot id: F7AX81
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9796:ALDOB
gene id: 9796:ALDOB
uniprot id: F6ULM3
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9796:CFDP1
gene id: 9796:CFDP1
uniprot id: F6QRX0
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

9796:CRCP
gene id: 9796:CRCP
uniprot id: F7BWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9796:HPDL
gene id: 9796:HPDL
uniprot id: F7CX45
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9796:STON1
gene id: 9796:STON1
uniprot id: A0A3Q2H017
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: May be involved in the endocytic machinery.

9796:PPIE
gene id: 9796:PPIE
uniprot id: F6Z5Z4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

9796:DAZAP2
gene id: 9796:DAZAP2
uniprot id: F7DIR9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9796:TMA16
gene id: 9796:TMA16
uniprot id: F7BZM7
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9796:ZRANB1
gene id: 9796:ZRANB1
uniprot id: F6SWW9
names: Similarity
messages: Belongs to the peptidase C64 family.

9796:CCDC188
gene id: 9796:CCDC188
uniprot id: A0A3Q2GTF7
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100050004
gene id: 9796:LOC100050004
uniprot id: F7C3A9
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

9796:LOC100062990
gene id: 9796:LOC100062990
uniprot id: A0A3Q2ICK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HSPH1
gene id: 9796:HSPH1
uniprot id: A0A5F5PL40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9796:RPS18
gene id: 9796:RPS18
uniprot id: F6T2L8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

9796:CDH19
gene id: 9796:CDH19
uniprot id: A0A3Q2I9J3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9796:COPS2
gene id: 9796:COPS2
uniprot id: F6SI35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

9796:FAM135A
gene id: 9796:FAM135A
uniprot id: F6QGN5
uniprot id: F6RFE4
names: Similarity
messages: Belongs to the FAM135 family.

9796:AKT2
gene id: 9796:AKT2
uniprot id: A0A5F5PYR8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9796:CCDC94
gene id: 9796:CCDC94
uniprot id: F6UPX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

9796:VPS33A
gene id: 9796:VPS33A
uniprot id: F6XZM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9796:LOC100067684
gene id: 9796:LOC100067684
uniprot id: F6VFT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:POLR2K
gene id: 9796:POLR2K
uniprot id: F6WFR2
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9796:VPS45
gene id: 9796:VPS45
uniprot id: F7A212
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9796:FOLR2
gene id: 9796:FOLR2
uniprot id: F7A0H6
names: Similarity
messages: Belongs to the folate receptor family.

9796:SSH2
gene id: 9796:SSH2
uniprot id: A0A3Q2IAT5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9796:HOXD12
gene id: 9796:HOXD12
uniprot id: F7E052
names: Subcellular Location Annotation
messages: Nucleus

9796:SLC16A6
gene id: 9796:SLC16A6
uniprot id: F6XI59
names: Subcellular Location Annotation
messages: Membrane

9796:CPEB4
gene id: 9796:CPEB4
uniprot id: A0A3Q2I6S4
names: Similarity
messages: Belongs to the RRM CPEB family.

9796:ALDH9A1
gene id: 9796:ALDH9A1
uniprot id: F6RI26
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9796:AQP6
gene id: 9796:AQP6
uniprot id: A0A5F5PU32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9796:LOC100062428
gene id: 9796:LOC100062428
uniprot id: F7D0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9796:PIK3C3
gene id: 9796:PIK3C3
uniprot id: A0A3Q2HDM7
uniprot id: A0A3Q2I5U9
uniprot id: F7C203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

9796:LOC100056780
gene id: 9796:LOC100056780
uniprot id: F6UFW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TMEM126A
gene id: 9796:TMEM126A
uniprot id: F6RI92
names: Subcellular Location Annotation
messages: Membrane

9796:FGF12
gene id: 9796:FGF12
uniprot id: A0A7U3JWE0
uniprot id: F6XEK8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9796:DHFR
gene id: 9796:DHFR
uniprot id: F6PUB9
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9796:WNT8B
gene id: 9796:WNT8B
uniprot id: A0A3Q2KV62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9796:EXOSC1
gene id: 9796:EXOSC1
uniprot id: A0A5F5PNC2
names: Subcellular Location Annotation
messages: Cytoplasm

9796:RETREG1
gene id: 9796:RETREG1
uniprot id: A0A5F5Q279
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9796:TBX6
gene id: 9796:TBX6
uniprot id: F6ZBV5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9796:KCNE1
gene id: 9796:KCNE1
uniprot id: F6WR21
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9796:COX6B1
gene id: 9796:COX6B1
uniprot id: F6SD71
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9796:SEPT6
gene id: 9796:SEPT6
uniprot id: F7CIZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9796:PSMD9
gene id: 9796:PSMD9
uniprot id: F7CPI8
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9796:ARL14
gene id: 9796:ARL14
uniprot id: F7DHA6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9796:AQP9
gene id: 9796:AQP9
uniprot id: A0A3Q2I697
uniprot id: F6QVP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9796:GAA
gene id: 9796:GAA
uniprot id: F6W5W1
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:LOC100059213
gene id: 9796:LOC100059213
uniprot id: F6SXX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LY49D
gene id: 9796:LY49D
uniprot id: Q75XR6
names: Subcellular Location Annotation
messages: Membrane

9796:HTR1A
gene id: 9796:HTR1A
uniprot id: Q0EAB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli (By similarity).
messages: Heterodimer; heterodimerizes with GPER1 (By similarity). Interacts with YIF1B (By similarity).
messages: dendrite

9796:CUTC
gene id: 9796:CUTC
uniprot id: F7CSI5
names: Similarity
messages: Belongs to the CutC family.

9796:CPSF4L
gene id: 9796:CPSF4L
uniprot id: F6RD98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9796:PKMYT1
gene id: 9796:PKMYT1
uniprot id: F6VTL4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:MAK16
gene id: 9796:MAK16
uniprot id: F6X0Z4
names: Similarity
messages: Belongs to the MAK16 family.

9796:SLC5A12
gene id: 9796:SLC5A12
uniprot id: F7AKS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9796:FTSJ3
gene id: 9796:FTSJ3
uniprot id: F6SYP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

9796:LECT2
gene id: 9796:LECT2
uniprot id: A0A3Q2HHG3
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9796:ZSCAN16
gene id: 9796:ZSCAN16
uniprot id: F6ZC00
names: Subcellular Location Annotation
messages: Nucleus

9796:POLR2H
gene id: 9796:POLR2H
uniprot id: F7AS10
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9796:FAM189B
gene id: 9796:FAM189B
uniprot id: A0A5F5Q020
uniprot id: F7DCV7
names: Similarity
messages: Belongs to the ENTREP family.

9796:CPLX3
gene id: 9796:CPLX3
uniprot id: F7A668
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9796:SLC39A12
gene id: 9796:SLC39A12
uniprot id: F7DSC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9796:CEP63
gene id: 9796:CEP63
uniprot id: A0A3Q2HY21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: centriolar satellite

9796:PSMB9
gene id: 9796:PSMB9
uniprot id: A0A3Q2GVY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9796:EQUCABV1R910
gene id: 9796:EQUCABV1R910
uniprot id: F7CA32
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:CSF2
gene id: 9796:CSF2
uniprot id: Q95L10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9796:DNASE1L3
gene id: 9796:DNASE1L3
uniprot id: F6V9S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Nucleus envelope
messages: Zymogen granule

9796:BBS4
gene id: 9796:BBS4
uniprot id: A0A3Q2KRP7
uniprot id: F7A6Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

9796:ITK
gene id: 9796:ITK
uniprot id: A0A3Q2HIP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9796:CSNK1A1
gene id: 9796:CSNK1A1
uniprot id: A0A3Q2IA95
uniprot id: A0A3Q2LBA4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9796:PPIL1
gene id: 9796:PPIL1
uniprot id: F6ZB40
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9796:TRUB1
gene id: 9796:TRUB1
uniprot id: F7C027
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9796:PAN2
gene id: 9796:PAN2
uniprot id: F7BTR4
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9796:HTR2B
gene id: 9796:HTR2B
uniprot id: F6V714
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via C-terminus) with MPDZ.
messages: Membrane
messages: synaptosome

9796:LOC100057880
gene id: 9796:LOC100057880
uniprot id: A0A3Q2I694
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MMP13
gene id: 9796:MMP13
uniprot id: O18927
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: N-glycosylated.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion (By similarity).
messages: Secreted
messages: Seems to be specific to breast carcinomas.
messages: The C-terminal region binds to collagen.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme (By similarity).
messages: The proenzyme is activated by removal of the propeptide; this cleavage can be effected by other matrix metalloproteinases, such as MMP2, MMP3 and MMP14 and may involve several cleavage steps. Cleavage can also be autocatalytic, after partial maturation by another protease or after treatment with 4-aminophenylmercuric acetate (APMA) (in vitro) (By similarity).
messages: Tyrosine phosphorylated by PKDCC/VLK.
messages: extracellular matrix

9796:RPS4X
gene id: 9796:RPS4X
uniprot id: F7DFM3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9796:LSM6
gene id: 9796:LSM6
uniprot id: F6THY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9796:WFIKKN1
gene id: 9796:WFIKKN1
uniprot id: F6WEE0
names: Similarity
messages: Belongs to the WFIKKN family.

9796:STX4
gene id: 9796:STX4
uniprot id: F6ZGZ1
names: Similarity
messages: Belongs to the syntaxin family.

9796:LOC100068560
gene id: 9796:LOC100068560
uniprot id: F6W7X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:C13H16orf58
gene id: 9796:C13H16orf58
uniprot id: A0A3Q2HXB5
names: Similarity
messages: Belongs to the RUS1 family.

9796:HK1
gene id: 9796:HK1
uniprot id: A0A3Q2GXD3
uniprot id: F7BA85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9796:DPM1
gene id: 9796:DPM1
uniprot id: F7AEN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9796:LOC100056577
gene id: 9796:LOC100056577
uniprot id: F6QN61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:EGR3
gene id: 9796:EGR3
uniprot id: A0A5F5PJA0
uniprot id: F7BXS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9796:THOC2
gene id: 9796:THOC2
uniprot id: A0A3Q2GWC8
uniprot id: F6PLG3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

9796:LOC100059452
gene id: 9796:LOC100059452
uniprot id: F6UM82
names: Similarity
messages: Belongs to the peptidase A1 family.

9796:GABRQ
gene id: 9796:GABRQ
uniprot id: A0A3Q2HTG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:LOC100056185
gene id: 9796:LOC100056185
uniprot id: F7AHU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TMEM86A
gene id: 9796:TMEM86A
uniprot id: A0A5F5PTB4
uniprot id: F7AQS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9796:LOC100057425
gene id: 9796:LOC100057425
uniprot id: F6YN05
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9796:HM13
gene id: 9796:HM13
uniprot id: A0A3Q2KKI1
uniprot id: F7DY53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9796:APOA2
gene id: 9796:APOA2
uniprot id: F6RM73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein A2 family.
messages: Secreted

9796:C5H1orf52
gene id: 9796:C5H1orf52
uniprot id: F6RKE1
names: Similarity
messages: Belongs to the UPF0690 family.

9796:CHMP3
gene id: 9796:CHMP3
uniprot id: F7DFE3
names: Similarity
messages: Belongs to the SNF7 family.

9796:YIPF7
gene id: 9796:YIPF7
uniprot id: F6XTP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9796:PRDX1
gene id: 9796:PRDX1
uniprot id: F6S6J4
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9796:LOC100058428
gene id: 9796:LOC100058428
uniprot id: F7AW30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LMLN
gene id: 9796:LMLN
uniprot id: F6R7I4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

9796:ERI1
gene id: 9796:ERI1
uniprot id: A0A3Q2GWA9
names: Subcellular Location Annotation
messages: Cytoplasm

9796:SUGP1
gene id: 9796:SUGP1
uniprot id: F7AJT8
names: Subcellular Location Annotation
messages: Nucleus

9796:KEF40 p12
gene id: 9796:KEF40_p12
uniprot id: G4RIT2
uniprot id: P48653
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9796:MYO18A
gene id: 9796:MYO18A
uniprot id: F6T845
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:ABR
gene id: 9796:ABR
uniprot id: A0A3Q2HNI0
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9796:DPCD
gene id: 9796:DPCD
uniprot id: A0A3Q2GU71
names: Similarity
messages: Belongs to the DPCD family.

9796:EQUCABV1R920
gene id: 9796:EQUCABV1R920
uniprot id: F7CF90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:AGRP
gene id: 9796:AGRP
uniprot id: F6XMN7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:LOC100064597
gene id: 9796:LOC100064597
uniprot id: A0A3Q2IA34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100067246
gene id: 9796:LOC100067246
uniprot id: A0A3Q2IDP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TUBB2A
gene id: 9796:TUBB2A
uniprot id: F7E0H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9796:PAG
gene id: 9796:PAG
uniprot id: Q28389
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase A1 family.
messages: Trophoblast and placental tissue.
messages: extracellular space

9796:SLC23A2
gene id: 9796:SLC23A2
uniprot id: F7BZY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9796:LOC100063748
gene id: 9796:LOC100063748
uniprot id: F7DV74
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TYRP1
gene id: 9796:TYRP1
uniprot id: F7BQT4
uniprot id: Q7PCK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9796:ACLY
gene id: 9796:ACLY
uniprot id: A0A3Q2HPV4
uniprot id: F6QDP0
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9796:LOC100051778
gene id: 9796:LOC100051778
uniprot id: F6PTY9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9796:YKT6
gene id: 9796:YKT6
uniprot id: A0A3Q2HFC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9796:SNAP25
gene id: 9796:SNAP25
uniprot id: A0A3Q2KN79
uniprot id: F6VJI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9796:FAM206A
gene id: 9796:FAM206A
uniprot id: F7C0H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9796:AMIGO2
gene id: 9796:AMIGO2
uniprot id: F7CBZ0
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9796:RPL3L
gene id: 9796:RPL3L
uniprot id: F6TCN4
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9796:YPEL2
gene id: 9796:YPEL2
uniprot id: F7AML1
names: Similarity
messages: Belongs to the yippee family.

9796:RUVBL1
gene id: 9796:RUVBL1
uniprot id: A0A3Q2HP89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9796:HIKESHI
gene id: 9796:HIKESHI
uniprot id: F6T775
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9796:KIF20A
gene id: 9796:KIF20A
uniprot id: F6WR77
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9796:CDC14A
gene id: 9796:CDC14A
uniprot id: A0A3Q2H7R5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9796:PDCL3
gene id: 9796:PDCL3
uniprot id: L7MRB2
names: Similarity
messages: Belongs to the phosducin family.

9796:C27H4orf47
gene id: 9796:C27H4orf47
uniprot id: F7A7P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0602 family.
messages: centrosome

9796:LOC100055600
gene id: 9796:LOC100055600
uniprot id: F6Y9H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TAF1D
gene id: 9796:TAF1D
uniprot id: F6RBU1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9796:OPA1
gene id: 9796:OPA1
uniprot id: F6Z1V1
uniprot id: F6Z2C8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9796:LOC100056936
gene id: 9796:LOC100056936
uniprot id: F7C0Y4
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9796:REEP2
gene id: 9796:REEP2
uniprot id: F6UY42
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:UBE2S
gene id: 9796:UBE2S
uniprot id: H9H019
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9796:CSNK1G3
gene id: 9796:CSNK1G3
uniprot id: A0A3Q2HVZ2
uniprot id: A0A3Q2HZS4
uniprot id: F7CH57
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9796:IL6ST
gene id: 9796:IL6ST
uniprot id: F7CFP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9796:EGFL7
gene id: 9796:EGFL7
uniprot id: A0A5F5PIM2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:UTP11
gene id: 9796:UTP11
uniprot id: F6WMD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9796:NME2
gene id: 9796:NME2
uniprot id: F6YY66
names: Similarity
messages: Belongs to the NDK family.

9796:SLC35A2
gene id: 9796:SLC35A2
uniprot id: A0A3Q2HPT9
uniprot id: F7C7T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9796:RIOK3
gene id: 9796:RIOK3
uniprot id: F6Y005
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

9796:SCN1B
gene id: 9796:SCN1B
uniprot id: F7CZ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon

9796:DEFB127
gene id: 9796:DEFB127
uniprot id: A0A3Q2GUX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9796:ARL6IP5
gene id: 9796:ARL6IP5
uniprot id: K9KB55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9796:LOC100070962
gene id: 9796:LOC100070962
uniprot id: A0A3Q2IM25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9796:LOC100070509
gene id: 9796:LOC100070509
uniprot id: A0A3Q2GUS9
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9796:INIP
gene id: 9796:INIP
uniprot id: F6WAD3
uniprot id: L7MS10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9796:NDUFB5
gene id: 9796:NDUFB5
uniprot id: F7CB31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9796:POLR3B
gene id: 9796:POLR3B
uniprot id: F7B4P7
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9796:PSMA1
gene id: 9796:PSMA1
uniprot id: F6WZW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9796:S100G
gene id: 9796:S100G
uniprot id: Q865V3
names: Similarity
messages: Belongs to the S-100 family.

9796:TEFM
gene id: 9796:TEFM
uniprot id: F6WQD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEFM family.
messages: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
messages: mitochondrion nucleoid

9796:CHRNB3
gene id: 9796:CHRNB3
uniprot id: F7D4Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:KCTD10
gene id: 9796:KCTD10
uniprot id: A0A3Q2IFW7
names: Similarity
messages: Belongs to the BACURD family.

9796:SLC46A1
gene id: 9796:SLC46A1
uniprot id: F6UGY6
names: Subcellular Location Annotation
messages: Membrane

9796:CSNK2B
gene id: 9796:CSNK2B
uniprot id: F6UJ03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9796:RPL19
gene id: 9796:RPL19
uniprot id: F6QDH0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9796:GJB4
gene id: 9796:GJB4
uniprot id: F6S785
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9796:PARP15
gene id: 9796:PARP15
uniprot id: A0A3Q2HSB8
uniprot id: F6S617
names: Similarity
messages: Belongs to the ARTD/PARP family.

9796:OPTN
gene id: 9796:OPTN
uniprot id: F6UWD8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Endosome
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9796:LOC100034242
gene id: 9796:LOC100034242
uniprot id: P00327
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Dimer of identical or non-identical chains of two types (E and S) coded by 2 separate genes at different loci.

9796:LOC100062329
gene id: 9796:LOC100062329
uniprot id: F7ASS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CCDC85A
gene id: 9796:CCDC85A
uniprot id: A0A3Q2H423
uniprot id: A0A3Q2HFV8
uniprot id: A0A3Q2HPR2
uniprot id: F6YUD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9796:LOC100072163
gene id: 9796:LOC100072163
uniprot id: A0A3Q2GY32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GUCA2A
gene id: 9796:GUCA2A
uniprot id: F7D0S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9796:OAS1
gene id: 9796:OAS1
uniprot id: Q5MYI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9796:LOC100071738
gene id: 9796:LOC100071738
uniprot id: F7B6R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GPR1
gene id: 9796:GPR1
uniprot id: F7AHQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9796:MEIS1
gene id: 9796:MEIS1
uniprot id: F6ZBX7
uniprot id: F7BRG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9796:KRT1
gene id: 9796:KRT1
uniprot id: F7B7X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9796:CHAC2
gene id: 9796:CHAC2
uniprot id: F7DH59
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9796:ARSJ
gene id: 9796:ARSJ
uniprot id: F6YAQ9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9796:SKA1
gene id: 9796:SKA1
uniprot id: F6UK20
names: Similarity
messages: Belongs to the SKA1 family.

9796:STN1
gene id: 9796:STN1
uniprot id: F7CV85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9796:CDH13
gene id: 9796:CDH13
uniprot id: A0A3Q2I839
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Membrane

9796:GPR161
gene id: 9796:GPR161
uniprot id: F7DDN9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:ERH
gene id: 9796:ERH
uniprot id: F7AUD4
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9796:SLC39A10
gene id: 9796:SLC39A10
uniprot id: F7A8U5
names: Subcellular Location Annotation
messages: Membrane

9796:GCLC
gene id: 9796:GCLC
uniprot id: F6RB82
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9796:SUPV3L1
gene id: 9796:SUPV3L1
uniprot id: F6YJ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9796:BARX2
gene id: 9796:BARX2
uniprot id: F7CBI3
names: Subcellular Location Annotation
messages: Nucleus

9796:SF3B3
gene id: 9796:SF3B3
uniprot id: F7BGG8
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100070749
gene id: 9796:LOC100070749
uniprot id: A0A3Q2I180
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100061835
gene id: 9796:LOC100061835
uniprot id: F6TF97
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ASIP
gene id: 9796:ASIP
uniprot id: Q95MP2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
messages: Secreted
messages: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

9796:FGFR2
gene id: 9796:FGFR2
uniprot id: A0A3Q2GYT7
uniprot id: A0A5F5PN21
uniprot id: F6S6I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9796:KCNJ5
gene id: 9796:KCNJ5
uniprot id: F6RSN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9796:NDUFB3
gene id: 9796:NDUFB3
uniprot id: F6UVC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9796:LOC100057888
gene id: 9796:LOC100057888
uniprot id: A0A3Q2LP95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SLC26A7
gene id: 9796:SLC26A7
uniprot id: A0A3Q2GTL1
uniprot id: A0A3Q2HPA8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:JAKMIP2
gene id: 9796:JAKMIP2
uniprot id: F6ZUD8
uniprot id: F7A013
names: Similarity
messages: Belongs to the JAKMIP family.

9796:PVALB
gene id: 9796:PVALB
uniprot id: C1L371
uniprot id: F6VNV4
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9796:LOC100071971
gene id: 9796:LOC100071971
uniprot id: F7D9A5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:PIPOX
gene id: 9796:PIPOX
uniprot id: F7DBT6
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9796:SLC25A14
gene id: 9796:SLC25A14
uniprot id: A0A3Q2HHI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9796:MED20
gene id: 9796:MED20
uniprot id: F7BTA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9796:TUBD1
gene id: 9796:TUBD1
uniprot id: A0A5F5PWB5
uniprot id: F6ZU39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9796:FAM13A
gene id: 9796:FAM13A
uniprot id: A0A5F5PF39
uniprot id: F7BVR4
uniprot id: F7BVS7
names: Similarity
messages: Belongs to the FAM13 family.

9796:LAMP5
gene id: 9796:LAMP5
uniprot id: A0A5F5PWT5
uniprot id: F6X052
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9796:CA10
gene id: 9796:CA10
uniprot id: F6R9S6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9796:CCDC90B
gene id: 9796:CCDC90B
uniprot id: L7MSF7
names: Similarity
messages: Belongs to the CCDC90 family.

9796:LOC100068626
gene id: 9796:LOC100068626
uniprot id: F6VTI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:DUPD1
gene id: 9796:DUPD1
uniprot id: P0C592
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Cytoplasm
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways (By similarity).
messages: Homodimer (By similarity). Interacts with PRKAA2 (By similarity).
messages: Nucleus

9796:NSDHL
gene id: 9796:NSDHL
uniprot id: F6V9H5
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9796:DGKD
gene id: 9796:DGKD
uniprot id: A0A5F5PZC9
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9796:TIGD6
gene id: 9796:TIGD6
uniprot id: Q4W445
names: Subcellular Location Annotation
messages: Nucleus

9796:HYOU1
gene id: 9796:HYOU1
uniprot id: F7BC94
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9796:TNMD
gene id: 9796:TNMD
uniprot id: Q95M14
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9796:ENTPD3
gene id: 9796:ENTPD3
uniprot id: F6RBQ4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9796:MED18
gene id: 9796:MED18
uniprot id: F7CY64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9796:XYLB
gene id: 9796:XYLB
uniprot id: A0A5F5Q2N9
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9796:AOX4
gene id: 9796:AOX4
uniprot id: M1ZMK5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9796:TRIM46
gene id: 9796:TRIM46
uniprot id: A0A5F5PVS0
names: Subcellular Location Annotation
messages: cytoskeleton

9796:ZSCAN22
gene id: 9796:ZSCAN22
uniprot id: F6THI9
names: Subcellular Location Annotation
messages: Nucleus

9796:PURG
gene id: 9796:PURG
uniprot id: A0A3Q2HXP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9796:MARVELD2
gene id: 9796:MARVELD2
uniprot id: A0A3Q2GVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9796:TOM1
gene id: 9796:TOM1
uniprot id: A0A3Q2IAX1
uniprot id: F6SCH8
names: Similarity
messages: Belongs to the TOM1 family.

9796:LOC100054259
gene id: 9796:LOC100054259
uniprot id: F7AC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9796:TSC22D4
gene id: 9796:TSC22D4
uniprot id: A0A3Q2I4W2
uniprot id: F6TZA6
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9796:CRYAA
gene id: 9796:CRYAA
uniprot id: P02478
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-70 may increase chaperone activity.
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA (By similarity).
messages: Nucleus
messages: Undergoes age-dependent proteolytical cleavage at the C-terminus.

9796:CARMIL1
gene id: 9796:CARMIL1
uniprot id: F6YQ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9796:EIF3E
gene id: 9796:EIF3E
uniprot id: F6R1D6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.

9796:GOLPH3L
gene id: 9796:GOLPH3L
uniprot id: F6X7B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9796:CENPC
gene id: 9796:CENPC
uniprot id: F7DKR0
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

9796:WNT10B
gene id: 9796:WNT10B
uniprot id: A0A3Q2HE93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9796:PIGK
gene id: 9796:PIGK
uniprot id: F7DJT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

9796:CYP2C92
gene id: 9796:CYP2C92
uniprot id: A7LGW8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9796:CDH6
gene id: 9796:CDH6
uniprot id: F6X200
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9796:TMED10
gene id: 9796:TMED10
uniprot id: F6S535
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:LOC100051754
gene id: 9796:LOC100051754
uniprot id: A0A3Q2H613
names: Similarity
messages: Belongs to the pro/parathymosin family.

9796:PRKACB
gene id: 9796:PRKACB
uniprot id: A0A3Q2HWB3
uniprot id: A0A3Q2LGK1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9796:AGL
gene id: 9796:AGL
uniprot id: A8BQB4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Monomer. Interacts with NHLRC1/malin (By similarity).
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
messages: Ubiquitinated.
messages: Ubiquitous. Expressed in striated skeletal muscle, heart, liver, spleen, skin, spinal cord, lung, kidney and testicle.

9796:SPTLC3
gene id: 9796:SPTLC3
uniprot id: F6TDJ5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9796:SCUBE3
gene id: 9796:SCUBE3
uniprot id: F7DUY3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9796:PER1
gene id: 9796:PER1
uniprot id: F7AU00
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9796:PSMB8
gene id: 9796:PSMB8
uniprot id: F6Z8V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9796:EXOG
gene id: 9796:EXOG
uniprot id: A0A5F5PS14
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9796:LOC100068151
gene id: 9796:LOC100068151
uniprot id: F6Y7V5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:TDP1
gene id: 9796:TDP1
uniprot id: F7ACN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9796:SLC50A1
gene id: 9796:SLC50A1
uniprot id: F7D9S0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9796:TPI1
gene id: 9796:TPI1
uniprot id: F6TZS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9796:IDO1
gene id: 9796:IDO1
uniprot id: F6WI76
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9796:CCDC22
gene id: 9796:CCDC22
uniprot id: A0A3Q2I3R5
names: Similarity
messages: Belongs to the CCDC22 family.

9796:LOC100071894
gene id: 9796:LOC100071894
uniprot id: F6VRT3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:NAA10
gene id: 9796:NAA10
uniprot id: F6VM75
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9796:LOC100058575
gene id: 9796:LOC100058575
uniprot id: F6RHU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9796:MMGT1
gene id: 9796:MMGT1
uniprot id: A0A3Q2H0T6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

9796:TMEM88
gene id: 9796:TMEM88
uniprot id: F6ZIM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9796:CTH
gene id: 9796:CTH
uniprot id: F7D1J3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9796:KCNAB1
gene id: 9796:KCNAB1
uniprot id: A0A3Q2H148
uniprot id: F7DLX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9796:EIF3H
gene id: 9796:EIF3H
uniprot id: K9K4A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9796:CTSS
gene id: 9796:CTSS
uniprot id: F6VUW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9796:PCLAF
gene id: 9796:PCLAF
uniprot id: F6PUE8
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

9796:ANXA13
gene id: 9796:ANXA13
uniprot id: F6PT14
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9796:CCL1
gene id: 9796:CCL1
uniprot id: A0A3Q2HK92
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9796:CCL19
gene id: 9796:CCL19
uniprot id: F7BIX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9796:TMEM242
gene id: 9796:TMEM242
uniprot id: F6W8V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9796:SLC7A2
gene id: 9796:SLC7A2
uniprot id: F6WVX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9796:LOC100067529
gene id: 9796:LOC100067529
uniprot id: F6VXS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MTMR4
gene id: 9796:MTMR4
uniprot id: A0A3Q2GSZ1
uniprot id: A0A3Q2H2K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9796:ROCK1
gene id: 9796:ROCK1
uniprot id: F6XUQ9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

9796:LOC102150892
gene id: 9796:LOC102150892
uniprot id: A0A3Q2IE11
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9796:GPM6A
gene id: 9796:GPM6A
uniprot id: A0A3Q2HIR4
uniprot id: F6WJF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9796:APOA1
gene id: 9796:APOA1
uniprot id: F6Z2L5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Extracellular vesicle
messages: Homotetramer. May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs. May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear. May interact with MAPT. May interact with MAP2. In the cerebrospinal fluid, interacts with secreted SORL1. Interacts with PMEL; this allows the loading of PMEL luminal fragment on ILVs to induce fibril nucleation.
messages: Vesicle
messages: extracellular matrix
messages: multivesicular body

9796:PLA2G4F
gene id: 9796:PLA2G4F
uniprot id: F6S266
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9796:INHBC
gene id: 9796:INHBC
uniprot id: F7DPX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9796:TEAD2
gene id: 9796:TEAD2
uniprot id: F7CI50
names: Subcellular Location Annotation
messages: Nucleus

9796:UCHL3
gene id: 9796:UCHL3
uniprot id: F6WKP5
names: Similarity
messages: Belongs to the peptidase C12 family.

9796:LOC100053325
gene id: 9796:LOC100053325
uniprot id: A0A3Q2KJ33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9796:CS
gene id: 9796:CS
uniprot id: F6XMS1
uniprot id: Q0QEK7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

9796:LOC100072184
gene id: 9796:LOC100072184
uniprot id: F7BW98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MS4A3
gene id: 9796:MS4A3
uniprot id: F6W5Q5
names: Similarity
messages: Belongs to the MS4A family.

9796:LOC100070849
gene id: 9796:LOC100070849
uniprot id: F7AWE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GRPR
gene id: 9796:GRPR
uniprot id: F7CVR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:THOC7
gene id: 9796:THOC7
uniprot id: F7C615
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

9796:SCAMP3
gene id: 9796:SCAMP3
uniprot id: A0A5F5PVD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9796:S100A6
gene id: 9796:S100A6
uniprot id: O77691
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Interacts with TPPP; this interaction inhibits TPPP dimerization (By similarity).
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).
messages: Nucleus envelope

9796:MAD1L1
gene id: 9796:MAD1L1
uniprot id: F6ZXL9
names: Similarity
messages: Belongs to the MAD1 family.

9796:BDNF
gene id: 9796:BDNF
uniprot id: Q0EAB7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).
messages: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.
messages: Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).
messages: Monomers and homodimers (By similarity). Binds to NTRK2/TRKB. Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (By similarity). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower affinity for the heterodimer formed by NGFR and SORCS2 (By similarity).
messages: N-glycosylated and glycosulfated, contrary to mature BDNF.
messages: Secreted

9796:ZNF263
gene id: 9796:ZNF263
uniprot id: F6YG67
names: Subcellular Location Annotation
messages: Nucleus

9796:RARB
gene id: 9796:RARB
uniprot id: F6YXU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9796:LOC100056394
gene id: 9796:LOC100056394
uniprot id: A0A3Q2I984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:CD44
gene id: 9796:CD44
uniprot id: A0A3Q2LHJ8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

9796:SLU7
gene id: 9796:SLU7
uniprot id: F6ZLU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9796:MMD2
gene id: 9796:MMD2
uniprot id: F6V502
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9796:MOCS1
gene id: 9796:MOCS1
uniprot id: A0A3Q2LQJ5
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9796:RIPOR3
gene id: 9796:RIPOR3
uniprot id: A0A3Q2HZ36
names: Similarity
messages: Belongs to the RIPOR family.

9796:TTC27
gene id: 9796:TTC27
uniprot id: A0A3Q2GW93
uniprot id: F6T720
names: Similarity
messages: Belongs to the TTC27 family.

9796:CLRN2
gene id: 9796:CLRN2
uniprot id: A0A3Q2I9E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9796:SLC51A
gene id: 9796:SLC51A
uniprot id: F6VI30
names: Subcellular Location Annotation
messages: Membrane

9796:LAMA2
gene id: 9796:LAMA2
uniprot id: F6R9F5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9796:PIGC
gene id: 9796:PIGC
uniprot id: K9K3U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9796:GAPDHS
gene id: 9796:GAPDHS
uniprot id: A0A5F5PLD3
uniprot id: F6RBE2
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9796:RTF2
gene id: 9796:RTF2
uniprot id: F6R4D7
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9796:HNF1B
gene id: 9796:HNF1B
uniprot id: F6WBR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9796:CLP1
gene id: 9796:CLP1
uniprot id: A0A3Q2HKP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9796:LOC100053069
gene id: 9796:LOC100053069
uniprot id: A0A3Q2I1R3
uniprot id: A0A7R8C3D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9796:LOC100072232
gene id: 9796:LOC100072232
uniprot id: F6RWG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TANGO6
gene id: 9796:TANGO6
uniprot id: F6V8P4
names: Similarity
messages: Belongs to the Tango6 family.

9796:CES2
gene id: 9796:CES2
uniprot id: F7BJ10
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9796:FKBP6
gene id: 9796:FKBP6
uniprot id: F6PHZ6
names: Caution
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity.
messages: Belongs to the FKBP6 family.
messages: Chromosome
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
messages: Defects in FKBP6 may be a cause of stallion sterility due to defects in acrosomal reaction. Disease susceptibility is associated with variants affecting the gene represented in this entry (PubMed:23284302).
messages: Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH; leading to inhibit GAPDH catalytic activity. Interacts (via TPR repeats) with HSP90 (By similarity).
messages: Nucleus
messages: Specifically expressed in testis and sperm.
messages: cytosol

9796:HCFC1
gene id: 9796:HCFC1
uniprot id: F6TVL2
names: Subcellular Location Annotation
messages: Nucleus

9796:PDCL2
gene id: 9796:PDCL2
uniprot id: F6SN00
names: Similarity
messages: Belongs to the phosducin family.

9796:ABCG2
gene id: 9796:ABCG2
uniprot id: F6Q6E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

9796:NETO1
gene id: 9796:NETO1
uniprot id: A0A3Q2GV82
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:LOC100066444
gene id: 9796:LOC100066444
uniprot id: A0A5F5PPW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9796:ERBB2
gene id: 9796:ERBB2
uniprot id: A0A3Q2H4E6
uniprot id: F6VNY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9796:RPL15
gene id: 9796:RPL15
uniprot id: F6RMA4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9796:PRRT1
gene id: 9796:PRRT1
uniprot id: F7C1I0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9796:CD40
gene id: 9796:CD40
uniprot id: Q3ZTK5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).
messages: Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).

9796:PIAS3
gene id: 9796:PIAS3
uniprot id: A0A3Q2HDE5
uniprot id: F6RAQ9
names: Similarity
messages: Belongs to the PIAS family.

9796:PDE4D
gene id: 9796:PDE4D
uniprot id: A0A5F5PZW9
uniprot id: A0A5F5Q0J1
uniprot id: F7ANH5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9796:ZNF706
gene id: 9796:ZNF706
uniprot id: F7AGE8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9796:TMC3
gene id: 9796:TMC3
uniprot id: F6TEP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9796:CTNNA2
gene id: 9796:CTNNA2
uniprot id: A0A5F5PNL6
uniprot id: A0A5F5PY68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction
messages: axon
messages: cytoskeleton

9796:ABCC2
gene id: 9796:ABCC2
uniprot id: F6VW89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9796:LOC100063645
gene id: 9796:LOC100063645
uniprot id: F6XJ24
names: Similarity
messages: Belongs to the cytochrome P450 family.

9796:FUT11
gene id: 9796:FUT11
uniprot id: F7A9J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9796:LRRC8A
gene id: 9796:LRRC8A
uniprot id: F7BJ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9796:TRAM2
gene id: 9796:TRAM2
uniprot id: F7C1P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9796:RNASE6
gene id: 9796:RNASE6
uniprot id: F7APT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9796:PANX1
gene id: 9796:PANX1
uniprot id: F7C3W9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9796:CHEK1
gene id: 9796:CHEK1
uniprot id: F6WF09
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9796:KLHL15
gene id: 9796:KLHL15
uniprot id: A0A5F5Q2V4
names: Subcellular Location Annotation
messages: Nucleus

9796:RBL1
gene id: 9796:RBL1
uniprot id: A0A3Q2HLF0
uniprot id: F6X9R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9796:IRAK2
gene id: 9796:IRAK2
uniprot id: F6RIT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9796:TOM1L1
gene id: 9796:TOM1L1
uniprot id: F7AJK0
names: Similarity
messages: Belongs to the TOM1 family.

9796:LOC100057985
gene id: 9796:LOC100057985
uniprot id: F7A8F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:RPS27L
gene id: 9796:RPS27L
uniprot id: F6PMX5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9796:ALAS2
gene id: 9796:ALAS2
uniprot id: A0A5F5PQU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9796:NUDT6
gene id: 9796:NUDT6
uniprot id: F7CAU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

9796:LTA
gene id: 9796:LTA
uniprot id: F7CF70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9796:HMGN2
gene id: 9796:HMGN2
uniprot id: A0A3Q2HB78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9796:TMSB15B
gene id: 9796:TMSB15B
uniprot id: A0A3Q2HW42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9796:LOC100060388
gene id: 9796:LOC100060388
uniprot id: A0A3Q2IDB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids, as well as bile acids, driven by an outward gradient of dicarboxylates such as glutarate or succinate (By similarity). Transports taurocholate, estrone 3-sulfate, and estradiol-17-glucuronide (17beta-estradiol 17-O-(beta-D-glucuronate)), but not androstanediol glucuronide (5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)) (PubMed:31553721).

9796:WWOX
gene id: 9796:WWOX
uniprot id: A0A5F5Q126
uniprot id: F6UD10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9796:CCDC86
gene id: 9796:CCDC86
uniprot id: F6TN71
names: Subcellular Location Annotation
messages: Nucleus

9796:FTCD
gene id: 9796:FTCD
uniprot id: F6RXZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds and promotes bundling of vimentin filaments originating from the Golgi.
messages: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
messages: Golgi apparatus
messages: Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.
messages: In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
messages: In the N-terminal section; belongs to the formiminotransferase family.
messages: centriole

9796:BEST4
gene id: 9796:BEST4
uniprot id: F7DLA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9796:CCNC
gene id: 9796:CCNC
uniprot id: F6WHE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
messages: Nucleus

9796:GPR55
gene id: 9796:GPR55
uniprot id: F7ADZ4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9796:ZW10
gene id: 9796:ZW10
uniprot id: F6TEA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

9796:GK
gene id: 9796:GK
uniprot id: A0A3Q2HIQ2
uniprot id: A0A3Q2I1I3
uniprot id: A0A3Q2IAK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9796:LIMS1
gene id: 9796:LIMS1
uniprot id: A0A5F5PK94
uniprot id: A0A5F5PYK1
uniprot id: A0A5F5Q0X2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9796:SEC11C
gene id: 9796:SEC11C
uniprot id: F6X2P5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:STK4
gene id: 9796:STK4
uniprot id: A0A3Q2HUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9796:MRPL18
gene id: 9796:MRPL18
uniprot id: F6SS95
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9796:MMAB
gene id: 9796:MMAB
uniprot id: A0A3Q2L7N9
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

9796:DARS
gene id: 9796:DARS
uniprot id: F6WZB7
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9796:LOC100069078
gene id: 9796:LOC100069078
uniprot id: F6U0U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:KRT7
gene id: 9796:KRT7
uniprot id: F7DZA2
names: Similarity
messages: Belongs to the intermediate filament family.

9796:PTEN
gene id: 9796:PTEN
uniprot id: A0A024QYT2
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

9796:LOC100062794
gene id: 9796:LOC100062794
uniprot id: F6WEX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:TBC1D7
gene id: 9796:TBC1D7
uniprot id: F6WQA7
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9796:SLCO1A2
gene id: 9796:SLCO1A2
uniprot id: F6R2Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9796:FREM1
gene id: 9796:FREM1
uniprot id: F6T9P2
names: Similarity
messages: Belongs to the FRAS1 family.

9796:OPRL1
gene id: 9796:OPRL1
uniprot id: F7DFS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

9796:SLC16A14
gene id: 9796:SLC16A14
uniprot id: F7A5W5
names: Subcellular Location Annotation
messages: Membrane

9796:EOGT
gene id: 9796:EOGT
uniprot id: A0A3Q2KMX4
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9796:PHF1
gene id: 9796:PHF1
uniprot id: F6W861
uniprot id: F6XCW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9796:EMP3
gene id: 9796:EMP3
uniprot id: F7BCU4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9796:LOC100053672
gene id: 9796:LOC100053672
uniprot id: A0A3Q2LRP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:AGMAT
gene id: 9796:AGMAT
uniprot id: F6TZ97
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

9796:OSBPL6
gene id: 9796:OSBPL6
uniprot id: A0A3Q2HMI2
uniprot id: A0A5F5PRE6
names: Similarity
messages: Belongs to the OSBP family.

9796:P3H2
gene id: 9796:P3H2
uniprot id: F6YCX7
names: Similarity
messages: Belongs to the leprecan family.

9796:COPE
gene id: 9796:COPE
uniprot id: F6Z2I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9796:KRT39
gene id: 9796:KRT39
uniprot id: F6QKF7
names: Similarity
messages: Belongs to the intermediate filament family.

9796:SPRY1
gene id: 9796:SPRY1
uniprot id: F7BIJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

9796:NR1H2
gene id: 9796:NR1H2
uniprot id: F6TR06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9796:CD8B
gene id: 9796:CD8B
uniprot id: A0A3Q2HZW6
names: Subcellular Location Annotation
messages: Membrane

9796:CEL
gene id: 9796:CEL
uniprot id: F7AGV7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9796:MITF
gene id: 9796:MITF
uniprot id: A0A3Q2I515
uniprot id: F7A3Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9796:TADA3
gene id: 9796:TADA3
uniprot id: F7CTJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9796:B3GAT1
gene id: 9796:B3GAT1
uniprot id: F6UN48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:TSEN2
gene id: 9796:TSEN2
uniprot id: F6QV95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9796:IQCG
gene id: 9796:IQCG
uniprot id: F6UBJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9796:LOC100067391
gene id: 9796:LOC100067391
uniprot id: F6U7A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MHCB3
gene id: 9796:MHCB3
uniprot id: Q30484
names: Similarity
messages: Belongs to the MHC class I family.

9796:LOC106781988
gene id: 9796:LOC106781988
uniprot id: F7DAU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:MNAT1
gene id: 9796:MNAT1
uniprot id: F6YP07
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9796:LOC100062625
gene id: 9796:LOC100062625
uniprot id: F6YB97
names: Subcellular Location Annotation
messages: Nucleus

9796:BCL2L13
gene id: 9796:BCL2L13
uniprot id: A0A3Q2IJR1
names: Similarity
messages: Belongs to the Bcl-2 family.

9796:RPL13A
gene id: 9796:RPL13A
uniprot id: A0A3Q2H097
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9796:SMIM15
gene id: 9796:SMIM15
uniprot id: F7B1M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9796:CCL2
gene id: 9796:CCL2
uniprot id: B1AB87
uniprot id: Q9TTQ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Monomer or homodimer; in equilibrium. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Interacts with TNFAIP6 (via Link domain).
messages: N-Glycosylated.
messages: Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).
messages: Secreted

9796:CXCL8
gene id: 9796:CXCL8
uniprot id: F6U909
uniprot id: O62812
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
messages: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
messages: Homodimer.
messages: Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.
messages: Secreted

9796:TMED6
gene id: 9796:TMED6
uniprot id: F6QGX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:LOC100058631
gene id: 9796:LOC100058631
uniprot id: A0A3Q2HRK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:ACAA2
gene id: 9796:ACAA2
uniprot id: K9K2H8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9796:LOC106781987
gene id: 9796:LOC106781987
uniprot id: F6SSI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:GSS
gene id: 9796:GSS
uniprot id: F6WSA6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9796:STRN3
gene id: 9796:STRN3
uniprot id: A0A3Q2HFF7
uniprot id: A0A3Q2LAB0
uniprot id: F7D0E4
uniprot id: F7DGQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9796:ANXA1
gene id: 9796:ANXA1
uniprot id: Q8HZM6
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
messages: Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation. Homodimers linked by transglutamylation are observed in placenta, but not in other tissues. Interacts with S100A11. Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (By similarity). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: Phosphorylated by protein kinase C, EGFR and TRPM7. Phosphorylated in response to EGF treatment.
messages: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
messages: Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26.
messages: Secreted
messages: Sumoylated.
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9796:CMC4
gene id: 9796:CMC4
uniprot id: A0A3Q2H379
names: Similarity
messages: Belongs to the CMC4 family.

9796:DPH3
gene id: 9796:DPH3
uniprot id: A0A5F5PR70
names: Similarity
messages: Belongs to the DPH3 family.

9796:RNASE9
gene id: 9796:RNASE9
uniprot id: W0UV08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Does not exhibit any ribonuclease activity.
messages: Secreted

9796:MRAP2
gene id: 9796:MRAP2
uniprot id: F7BRV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9796:PEBP1
gene id: 9796:PEBP1
uniprot id: F6QXW2
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9796:TMCC1
gene id: 9796:TMCC1
uniprot id: F6U1U7
names: Similarity
messages: Belongs to the TEX28 family.

9796:CAPN5
gene id: 9796:CAPN5
uniprot id: A0A3Q2H6E7
names: Similarity
messages: Belongs to the peptidase C2 family.

9796:IL1B
gene id: 9796:IL1B
uniprot id: A0A5F5Q2Z8
uniprot id: Q28386
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling. Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form. Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC. Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC.
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9796:DR1
gene id: 9796:DR1
uniprot id: F6R635
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9796:KRT42
gene id: 9796:KRT42
uniprot id: A0A3Q2GXH5
names: Similarity
messages: Belongs to the intermediate filament family.

9796:LIN28A
gene id: 9796:LIN28A
uniprot id: F7DH54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9796:SLCO5A1
gene id: 9796:SLCO5A1
uniprot id: A0A3Q2H4X7
uniprot id: F6W2J1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9796:RAD51
gene id: 9796:RAD51
uniprot id: F6SWI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9796:LOC100057466
gene id: 9796:LOC100057466
uniprot id: A0A3Q2H873
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:POLR2J
gene id: 9796:POLR2J
uniprot id: A0A3Q2IGJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9796:GTPBP10
gene id: 9796:GTPBP10
uniprot id: F6QNV9
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9796:TASP1
gene id: 9796:TASP1
uniprot id: A0A3Q2LTZ3
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9796:ATXN3
gene id: 9796:ATXN3
uniprot id: K9K2B3
names: Subcellular Location Annotation
messages: Nucleus

9796:PFKFB4
gene id: 9796:PFKFB4
uniprot id: F6RSD3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9796:FGD4
gene id: 9796:FGD4
uniprot id: A0A3Q2HK59
uniprot id: A0A3Q2HZZ7
names: Subcellular Location Annotation
messages: cytoskeleton

9796:EQUCABV1R931
gene id: 9796:EQUCABV1R931
uniprot id: A0A3Q2GYX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9796:LOC100072227
gene id: 9796:LOC100072227
uniprot id: F7DEG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100071910
gene id: 9796:LOC100071910
uniprot id: F6T2T2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:UROS
gene id: 9796:UROS
uniprot id: F6SZ75
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9796:EPHB6
gene id: 9796:EPHB6
uniprot id: A0A3Q2HJF9
names: Subcellular Location Annotation
messages: Membrane

9796:AKAP5
gene id: 9796:AKAP5
uniprot id: F6YIT2
names: Subcellular Location Annotation
messages: Membrane

9796:LOC100058071
gene id: 9796:LOC100058071
uniprot id: F7AB52
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9796:NPPA
gene id: 9796:NPPA
uniprot id: P27104
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Cleavage by MME initiates degradation of the factor and thereby regulates its activity. Degradation by IDE results in reduced activation of NPR1 (in vitro). During IDE degradation, the resulting products can temporarily stimulate NPR2 to produce cGMP, before the fragments are completely degraded and inactivated by IDE (in vitro).
messages: Degraded by IDE.
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.
messages: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (By similarity). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (By similarity). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity).
messages: May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity).
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Perikaryon
messages: Phosphorylation on Ser-129 decreases vasorelaxant activity.
messages: Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, a heterologous and in vivo expression study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).
messages: Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, an in vivo study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).
messages: Secreted
messages: The precursor molecule is proteolytically cleaved by CORIN at Arg-123 to produce the atrial natriuretic peptide (By similarity). Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide (By similarity). Additional processing gives rise to the auriculin and atriopeptin peptides (By similarity). In the kidneys, alternative processing by an unknown protease results in the peptide urodilatin (By similarity).

9796:HNRNPC
gene id: 9796:HNRNPC
uniprot id: A0A3Q2I630
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9796:GABRB2
gene id: 9796:GABRB2
uniprot id: A0A5F5PJN5
uniprot id: F6WVB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9796:GMNN
gene id: 9796:GMNN
uniprot id: F6YW53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9796:KCNN3
gene id: 9796:KCNN3
uniprot id: F7AWG9
names: Subcellular Location Annotation
messages: Membrane

9796:CNFN
gene id: 9796:CNFN
uniprot id: F6X292
names: Similarity
messages: Belongs to the cornifelin family.

9796:POLR3H
gene id: 9796:POLR3H
uniprot id: A0A3Q2KX14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

9796:LOC100072633
gene id: 9796:LOC100072633
uniprot id: F7AMV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:HOXB6
gene id: 9796:HOXB6
uniprot id: F6QVG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9796:MYT1L
gene id: 9796:MYT1L
uniprot id: A0A3Q2I8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9796:MUSTN1
gene id: 9796:MUSTN1
uniprot id: F6YBP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9796:NUP155
gene id: 9796:NUP155
uniprot id: F7CDY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.
messages: nuclear pore complex

9796:TEAD1
gene id: 9796:TEAD1
uniprot id: A0A3Q2LPX7
names: Subcellular Location Annotation
messages: Nucleus

9796:LOC100065632
gene id: 9796:LOC100065632
uniprot id: F6W002
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:SMIM19
gene id: 9796:SMIM19
uniprot id: F7DTA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9796:CELF3
gene id: 9796:CELF3
uniprot id: A0A3Q2L6U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9796:TMEM94
gene id: 9796:TMEM94
uniprot id: A0A5F5PW04
uniprot id: F6YI77
names: Subcellular Location Annotation
messages: Membrane

9796:TMOD4
gene id: 9796:TMOD4
uniprot id: F6ZCV2
names: Subcellular Location Annotation
messages: cytoskeleton

9796:MEIS2
gene id: 9796:MEIS2
uniprot id: F6X2C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9796:PHYHIP
gene id: 9796:PHYHIP
uniprot id: A0A3Q2HET4
names: Similarity
messages: Belongs to the PHYHIP family.

9796:KEF40 p10
gene id: 9796:KEF40_p10
uniprot id: A5JYB7
uniprot id: P48660
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9796:GH1
gene id: 9796:GH1
uniprot id: P01245
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9796:MFRP
gene id: 9796:MFRP
uniprot id: F6Q3D3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9796:NDUFB4
gene id: 9796:NDUFB4
uniprot id: F6VCX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9796:LOC100063353
gene id: 9796:LOC100063353
uniprot id: F6Q8H5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9796:TMEM229B
gene id: 9796:TMEM229B
uniprot id: A0A3Q2LU88
uniprot id: A0A5F5PQN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9796:FUT8
gene id: 9796:FUT8
uniprot id: F7DPM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9796:RPS16
gene id: 9796:RPS16
uniprot id: F6Q4A3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9796:LOC100061035
gene id: 9796:LOC100061035
uniprot id: L7MRN6
names: Similarity
messages: Belongs to the MHC class II family.

9796:NIPAL1
gene id: 9796:NIPAL1
uniprot id: F7DYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9796:GPX5
gene id: 9796:GPX5
uniprot id: A0A3Q2KSE6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9796:RSPO2
gene id: 9796:RSPO2
uniprot id: A8C9U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9796:C3H4orf22
gene id: 9796:C3H4orf22
uniprot id: F6VCG7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

9796:PERP
gene id: 9796:PERP
uniprot id: F6PQL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9796:HEXA
gene id: 9796:HEXA
uniprot id: F6T7J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9796:PIGN
gene id: 9796:PIGN
uniprot id: A0A5F5PEE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

9796:CXCL10
gene id: 9796:CXCL10
uniprot id: B1AB90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9796:MID1IP1
gene id: 9796:MID1IP1
uniprot id: F6XDI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9796:GPD1
gene id: 9796:GPD1
uniprot id: A0A3Q2HV72
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9796:RPLP2
gene id: 9796:RPLP2
uniprot id: Q6X9Z5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9796:LOC100072221
gene id: 9796:LOC100072221
uniprot id: F7DFI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:POLR2E
gene id: 9796:POLR2E
uniprot id: A0A3Q2LDU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

9796:PKP4
gene id: 9796:PKP4
uniprot id: A0A3Q2HVY2
uniprot id: A0A3Q2IAZ7
uniprot id: A0A5F5PLT2
names: Similarity
messages: Belongs to the beta-catenin family.

9796:PGAM2
gene id: 9796:PGAM2
uniprot id: F7A616
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9796:BRMS1
gene id: 9796:BRMS1
uniprot id: F6RAC3
names: Subcellular Location Annotation
messages: Nucleus

9796:CUEDC2
gene id: 9796:CUEDC2
uniprot id: F7DA38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9796:LOC100072672
gene id: 9796:LOC100072672
uniprot id: F6WLN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9796:DIABLO
gene id: 9796:DIABLO
uniprot id: F7D7B2
names: Subcellular Location Annotation
messages: Mitochondrion

9796:AP2M1
gene id: 9796:AP2M1
uniprot id: A0A5F5PGP7
uniprot id: F7DK60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9796:CHST11
gene id: 9796:CHST11
uniprot id: F7E238
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9796:PROK1
gene id: 9796:PROK1
uniprot id: A0A3Q2HU93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9796:DCAF13
gene id: 9796:DCAF13
uniprot id: F6ZBF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

9796:STAT1
gene id: 9796:STAT1
uniprot id: A0A3Q2L3I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9796:CCND2
gene id: 9796:CCND2
uniprot id: F6SA01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9796:GALE
gene id: 9796:GALE
uniprot id: F6SUZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9796:LOC100071278
gene id: 9796:LOC100071278
uniprot id: F7CTP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:LOC100069259
gene id: 9796:LOC100069259
uniprot id: F6V0S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9796:VAMP1
gene id: 9796:VAMP1
uniprot id: A0A5F5PY81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9796:MPO
gene id: 9796:MPO
uniprot id: F7BZ88
names: Cofactor
messages: Binds 1 Ca(2+) ion per monomer.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.

9796:PLA2G4A
gene id: 9796:PLA2G4A
uniprot id: A0A3Q2H7S2
uniprot id: O77793
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activated by cytosolic calcium, which is necessary for binding to membrane lipids. Activated by phosphorylation in response to mitogenic stimuli.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (By similarity). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity).
messages: Interacts with KAT5.
messages: Nucleus envelope
messages: Phosphorylated at both Ser-505 and Ser-727 in response to mitogenic stimuli.
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic calcium. In the presence of phosphoinositides, regulates phospholipase A2 and lysophospholipase activities in a calcium-independent way.

9796:CLIC2
gene id: 9796:CLIC2
uniprot id: F6UF33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

9796:CTTNBP2
gene id: 9796:CTTNBP2
uniprot id: Q2QLA2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.
messages: Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
messages: cell cortex
messages: dendritic spine

9796:CYP3A95
gene id: 9796:CYP3A95
uniprot id: D7GB58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane