9685:LOC102899058
gene id: 9685:LOC102899058
uniprot id: M3XEQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PLA2G12A
gene id: 9685:PLA2G12A
uniprot id: A0A5F5XI58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Belongs to the phospholipase A2 family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus
messages: Secreted

9685:SLC35B4
gene id: 9685:SLC35B4
uniprot id: M3WHT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9685:SYN1
gene id: 9685:SYN1
uniprot id: M3W948
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synapsin family.
messages: Golgi apparatus
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: synaptic vesicle

9685:CNR1
gene id: 9685:CNR1
uniprot id: O02777
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in cerebral arterial muscle cells and cerebral cortex (at protein level).
messages: G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constituti…
messages: Hemopressin, a peptide derived from hemoglobin subunit alpha (HBA1 and/or HBA2), acts as an antagonist peptide: hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Interacts (via C-terminus) with CNRIP1; this interaction attenuates constitutive, but not agonist-dependent, inhibition of voltage-gated Ca(2+) channels in neurons (By similarity). Associates with G protein alpha subunits, including G(i) alpha-1/GNAI1, G(i) alpha-3/GNAI3 and G(o)-alpha/GNAO1; palmitoylation is important for interaction with GNAI3 and GNAO1 (By similarity).
messages: Membrane raft
messages: Mitochondrion outer membrane
messages: Palmitoylation at Cys-415 is important for recruitment at plasma membrane and lipid rafts and association with G protein alpha subunits.
messages: Presynapse
messages: axon

9685:PLIN5
gene id: 9685:PLIN5
uniprot id: M3WPA9
names: Similarity
messages: Belongs to the perilipin family.

9685:PDP2
gene id: 9685:PDP2
uniprot id: M3W5L0
names: Similarity
messages: Belongs to the PP2C family.

9685:RBFOX3
gene id: 9685:RBFOX3
uniprot id: M3VYQ8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9685:CYBA
gene id: 9685:CYBA
uniprot id: M3W6A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9685:ZDHHC15
gene id: 9685:ZDHHC15
uniprot id: A0A337SM53
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:KATNB1
gene id: 9685:KATNB1
uniprot id: M3VYZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9685:VPS25
gene id: 9685:VPS25
uniprot id: A0A2I2UFC7
names: Similarity
messages: Belongs to the VPS25 family.

9685:GABRE
gene id: 9685:GABRE
uniprot id: M3W4A9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:TRAPPC11
gene id: 9685:TRAPPC11
uniprot id: M3WTQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPPC11 family.
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

9685:ZP1
gene id: 9685:ZP1
uniprot id: I6M4H3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Zona pellucida

9685:TAFA4
gene id: 9685:TAFA4
uniprot id: A0A2I2UXN6
names: Similarity
messages: Belongs to the TAFA family.

9685:FOXP2
gene id: 9685:FOXP2
uniprot id: A9UCM4
names: Subcellular Location Annotation
messages: Nucleus

9685:NUS1
gene id: 9685:NUS1
uniprot id: M3XAC4
names: Similarity
messages: Belongs to the UPP synthase family.

9685:AIDA
gene id: 9685:AIDA
uniprot id: M3VY63
names: Similarity
messages: Belongs to the AIDA family.

9685:STN1
gene id: 9685:STN1
uniprot id: M3XA04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9685:SAP30
gene id: 9685:SAP30
uniprot id: M3WR27
names: Similarity
messages: Belongs to the SAP30 family.

9685:PLA2G4F
gene id: 9685:PLA2G4F
uniprot id: M3XAF2
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9685:SMUG1
gene id: 9685:SMUG1
uniprot id: A0A2I2U349
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9685:CD6
gene id: 9685:CD6
uniprot id: A0A5F5XZ00
uniprot id: M3WJ99
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:MAP1LC3C
gene id: 9685:MAP1LC3C
uniprot id: A0A337S3R3
names: Similarity
messages: Belongs to the ATG8 family.

9685:SUCLA2
gene id: 9685:SUCLA2
uniprot id: M3WQ50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9685:GSTZ1
gene id: 9685:GSTZ1
uniprot id: A0A2I2UUQ5
uniprot id: M3WFN1
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9685:HARS1
gene id: 9685:HARS1
uniprot id: M3VWD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9685:VIP
gene id: 9685:VIP
uniprot id: M3VY16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

9685:LOC101093722
gene id: 9685:LOC101093722
uniprot id: A0A5F5XRU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:FFAR2
gene id: 9685:FFAR2
uniprot id: A0A7G1GES3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9685:GDF11
gene id: 9685:GDF11
uniprot id: M3WSH4
names: Similarity
messages: Belongs to the TGF-beta family.

9685:ZFX
gene id: 9685:ZFX
uniprot id: M3WDG5
names: Subcellular Location Annotation
messages: Nucleus

9685:NR3C2
gene id: 9685:NR3C2
uniprot id: A0A2I2UTD1
uniprot id: M3WTD2
names: Subcellular Location Annotation
messages: Nucleus

9685:CB4H12orf57
gene id: 9685:CB4H12orf57
uniprot id: M3W1X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

9685:BIRC5
gene id: 9685:BIRC5
uniprot id: Q6I6F4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.
messages: Belongs to the IAP family.
messages: Chromosome
messages: Cytoplasm
messages: In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity. Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis.
messages: Midbody
messages: Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8. Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce. Interacts with FBXL7; this interaction facilitates the polyubiquitination and subsequent proteasomal degradation of BIRC5 by the SCF(FBXL7) E3 ubiquitin-protein ligase complex (By similarity).
messages: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity).
messages: Nucleus
messages: The BIR repeat is necessary and sufficient for LAMTOR5 binding.
messages: Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.
messages: centromere
messages: kinetochore
messages: spindle

9685:ARRDC3
gene id: 9685:ARRDC3
uniprot id: M3WPP8
names: Similarity
messages: Belongs to the arrestin family.

9685:VPS28
gene id: 9685:VPS28
uniprot id: M3WKL6
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

9685:SLC5A12
gene id: 9685:SLC5A12
uniprot id: M3WJJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9685:NHSL2
gene id: 9685:NHSL2
uniprot id: A0A2I2USG6
names: Similarity
messages: Belongs to the NHS family.

9685:MS4A7
gene id: 9685:MS4A7
uniprot id: M3W7D8
names: Similarity
messages: Belongs to the MS4A family.

9685:GRIN2B
gene id: 9685:GRIN2B
uniprot id: M3WID6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9685:CSN3
gene id: 9685:CSN3
uniprot id: M3WKE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Secreted

9685:COPG1
gene id: 9685:COPG1
uniprot id: A0A2I2UWG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9685:ISCA2
gene id: 9685:ISCA2
uniprot id: A0A2I2UPN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9685:COX11
gene id: 9685:COX11
uniprot id: A0A2I2UXD4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9685:NR0B1
gene id: 9685:NR0B1
uniprot id: M3WQZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9685:EDA
gene id: 9685:EDA
uniprot id: A0A337S6U3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9685:ALG5
gene id: 9685:ALG5
uniprot id: M3W109
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9685:GATM
gene id: 9685:GATM
uniprot id: M3X5Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.
messages: Homodimer.
messages: Mitochondrion inner membrane

9685:TOM1L1
gene id: 9685:TOM1L1
uniprot id: M3VZB5
names: Similarity
messages: Belongs to the TOM1 family.

9685:SH3GLB1
gene id: 9685:SH3GLB1
uniprot id: A0A2I2UWF0
uniprot id: A0A337S4S3
uniprot id: M3XAM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9685:CYB5R2
gene id: 9685:CYB5R2
uniprot id: M3W5X3
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9685:HOXC10
gene id: 9685:HOXC10
uniprot id: M3WEN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9685:SLC29A2
gene id: 9685:SLC29A2
uniprot id: M3WNX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9685:MASTL
gene id: 9685:MASTL
uniprot id: M3WKC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Nucleus
messages: centrosome

9685:TRAF6
gene id: 9685:TRAF6
uniprot id: A0A337SQ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9685:GPER1
gene id: 9685:GPER1
uniprot id: A0A337SDC2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:LOC101082275
gene id: 9685:LOC101082275
uniprot id: M3X0T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MYF6
gene id: 9685:MYF6
uniprot id: M3WLS1
names: Subcellular Location Annotation
messages: Nucleus

9685:FA2H
gene id: 9685:FA2H
uniprot id: M3WM14
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:CNDP2
gene id: 9685:CNDP2
uniprot id: M3W9A2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9685:GFOD2
gene id: 9685:GFOD2
uniprot id: M3W0F7
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9685:UGT1A1
gene id: 9685:UGT1A1
uniprot id: M3WBX4
uniprot id: O46548
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9685:LIF
gene id: 9685:LIF
uniprot id: A0A2I2UME6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

9685:ACSS1
gene id: 9685:ACSS1
uniprot id: M3WKW5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9685:LOC105259999
gene id: 9685:LOC105259999
uniprot id: M3XEZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CA5B
gene id: 9685:CA5B
uniprot id: M3WVV0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9685:TXNL4B
gene id: 9685:TXNL4B
uniprot id: M3W4S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9685:KCNG4
gene id: 9685:KCNG4
uniprot id: M3WFB4
names: Subcellular Location Annotation
messages: Membrane

9685:MYO5C
gene id: 9685:MYO5C
uniprot id: M3WH72
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9685:RUVBL1
gene id: 9685:RUVBL1
uniprot id: M3WAA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9685:TENT5D
gene id: 9685:TENT5D
uniprot id: M3X0P8
names: Similarity
messages: Belongs to the TENT family.

9685:ITPA
gene id: 9685:ITPA
uniprot id: A0A337S0L8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9685:UBXN1
gene id: 9685:UBXN1
uniprot id: M3WAD2
names: Subcellular Location Annotation
messages: Cytoplasm

9685:CCL19
gene id: 9685:CCL19
uniprot id: M3VZU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:XRN2
gene id: 9685:XRN2
uniprot id: M3W8Q9
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9685:PEX5L
gene id: 9685:PEX5L
uniprot id: A0A2I2U759
uniprot id: A0A2I2U771
uniprot id: A0A337S7H6
uniprot id: A0A337SUN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Membrane

9685:KIF2C
gene id: 9685:KIF2C
uniprot id: A0A2I2US90
uniprot id: A0A337S7F1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:GCG
gene id: 9685:GCG
uniprot id: M3XDH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9685:CENPN
gene id: 9685:CENPN
uniprot id: A0A5F5XWD3
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9685:CCR2
gene id: 9685:CCR2
uniprot id: A5A4S1
uniprot id: A5A4S2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:LOC101099384
gene id: 9685:LOC101099384
uniprot id: M3X8K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MBOAT7
gene id: 9685:MBOAT7
uniprot id: A0A337SSR2
names: Subcellular Location Annotation
messages: Membrane

9685:MED17
gene id: 9685:MED17
uniprot id: A0A2I2UVT9
uniprot id: A0A337S6P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9685:LOC101087365
gene id: 9685:LOC101087365
uniprot id: M3WQ25
names: Similarity
messages: Belongs to the intermediate filament family.

9685:GDPD3
gene id: 9685:GDPD3
uniprot id: A0A5F5XDL4
uniprot id: M3XAE5
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9685:SHOC2
gene id: 9685:SHOC2
uniprot id: A0A337SSD8
names: Function
names: Similarity
messages: Belongs to the SHOC2 family.
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

9685:LOC101099760
gene id: 9685:LOC101099760
uniprot id: M3X6S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:ATP6V1G3
gene id: 9685:ATP6V1G3
uniprot id: A0A2I2UKP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9685:TNFSF10
gene id: 9685:TNFSF10
uniprot id: B4XH67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9685:DTX3L
gene id: 9685:DTX3L
uniprot id: M3VVN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9685:PPM1G
gene id: 9685:PPM1G
uniprot id: M3WP20
names: Similarity
messages: Belongs to the PP2C family.

9685:IFT57
gene id: 9685:IFT57
uniprot id: M3WTC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9685:FAM216B
gene id: 9685:FAM216B
uniprot id: A0A2I2UBY9
names: Similarity
messages: Belongs to the FAM216 family.

9685:TNS2
gene id: 9685:TNS2
uniprot id: A0A5F5XQ99
uniprot id: M3VUH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9685:SLC37A4
gene id: 9685:SLC37A4
uniprot id: A0A2I2U150
uniprot id: A0A5F5XYT0
uniprot id: M3VW29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9685:PTGS2
gene id: 9685:PTGS2
uniprot id: A8QIU4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane
messages: Nucleus inner membrane
messages: Nucleus outer membrane

9685:CSTF2
gene id: 9685:CSTF2
uniprot id: A0A2I2US86
uniprot id: A0A5F5XJN8
uniprot id: M3W6W5
names: Subcellular Location Annotation
messages: Nucleus

9685:GALM
gene id: 9685:GALM
uniprot id: M3WQR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

9685:NUBPL
gene id: 9685:NUBPL
uniprot id: M3WTW9
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9685:KALRN
gene id: 9685:KALRN
uniprot id: A0A5F5XLT6
uniprot id: M3WWH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm

9685:HES7
gene id: 9685:HES7
uniprot id: A0A5F5Y0S1
uniprot id: M3WM48
names: Subunit
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

9685:DEFB123
gene id: 9685:DEFB123
uniprot id: A0A2I2UFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9685:ACTR6
gene id: 9685:ACTR6
uniprot id: A0A337STW7
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

9685:MTCP1
gene id: 9685:MTCP1
uniprot id: M3X1T5
names: Similarity
messages: Belongs to the TCL1 family.

9685:EIF4A2
gene id: 9685:EIF4A2
uniprot id: M3WJN3
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9685:GDPGP1
gene id: 9685:GDPGP1
uniprot id: M3W3S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9685:TRAM2
gene id: 9685:TRAM2
uniprot id: M3VZI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9685:LRRC51
gene id: 9685:LRRC51
uniprot id: M3W3V4
names: Subcellular Location Annotation
messages: Cytoplasm

9685:ADIPOR1
gene id: 9685:ADIPOR1
uniprot id: B5BNW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9685:PSPC1
gene id: 9685:PSPC1
uniprot id: M3X0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSPC family.
messages: Cytoplasm
messages: Nucleus matrix
messages: Nucleus speckle
messages: nucleolus

9685:DNPH1
gene id: 9685:DNPH1
uniprot id: M3WBZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

9685:MIP
gene id: 9685:MIP
uniprot id: M3WG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9685:VIRMA
gene id: 9685:VIRMA
uniprot id: A0A2I2UHJ3
names: Similarity
messages: Belongs to the vir family.

9685:KDELR1
gene id: 9685:KDELR1
uniprot id: M3VVR4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:AZIN1
gene id: 9685:AZIN1
uniprot id: M3WCK7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9685:SKA1
gene id: 9685:SKA1
uniprot id: M3WU02
names: Similarity
messages: Belongs to the SKA1 family.

9685:USP26
gene id: 9685:USP26
uniprot id: M3WQL5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9685:LOC101088501
gene id: 9685:LOC101088501
uniprot id: A0A2I2UNC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:NFX1
gene id: 9685:NFX1
uniprot id: M3WS67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9685:THRA
gene id: 9685:THRA
uniprot id: A0A2I2UWD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9685:MAN2A2
gene id: 9685:MAN2A2
uniprot id: A0A5F5XUG7
uniprot id: M3W597
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9685:ARHGEF3
gene id: 9685:ARHGEF3
uniprot id: A0A2I2U7L5
uniprot id: A0A2I2UNB0
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9685:CENPL
gene id: 9685:CENPL
uniprot id: M3WI40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9685:LOC101091078
gene id: 9685:LOC101091078
uniprot id: M3X708
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RPS20
gene id: 9685:RPS20
uniprot id: M3XBC9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9685:DPF2
gene id: 9685:DPF2
uniprot id: M3X3X4
names: Similarity
messages: Belongs to the requiem/DPF family.

9685:ACTB
gene id: 9685:ACTB
uniprot id: M3WRZ7
names: Similarity
messages: Belongs to the actin family.

9685:MLPH
gene id: 9685:MLPH
uniprot id: M3WHG5
names: Function
names: Polymorphism
names: Subcellular Location Annotation
names: Subunit
messages: An allelic variation in MLPH, resulting in a severely truncated protein, has been shown to be associated with the dilute coat color phenotype. This trait is autosomal recessive.
messages: Binds RAB27A that has been activated by GTP-binding via its N-terminus. Binds MYO5A via its C-terminal coiled coil domain.
messages: Melanosome
messages: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.

9685:BLCAP
gene id: 9685:BLCAP
uniprot id: P62953
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and nuclear factor kappa B (NF-kappaB).
messages: Membrane

9685:NCBP2
gene id: 9685:NCBP2
uniprot id: M3XAX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9685:KRT19
gene id: 9685:KRT19
uniprot id: M3VXK3
names: Similarity
messages: Belongs to the intermediate filament family.

9685:TEX261
gene id: 9685:TEX261
uniprot id: M3WIW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9685:HSPB6
gene id: 9685:HSPB6
uniprot id: M3W5U0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.
messages: Nucleus

9685:LOC101091589
gene id: 9685:LOC101091589
uniprot id: M3X8A5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC109494884
gene id: 9685:LOC109494884
uniprot id: M3WA03
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9685:L3MBTL2
gene id: 9685:L3MBTL2
uniprot id: M3W0R6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9685:SERPINI1
gene id: 9685:SERPINI1
uniprot id: M3W7B6
names: Similarity
messages: Belongs to the serpin family.

9685:ENPP3
gene id: 9685:ENPP3
uniprot id: A0A2I2V568
uniprot id: M3WK44
names: Subcellular Location Annotation
messages: Secreted

9685:PPP2CA
gene id: 9685:PPP2CA
uniprot id: A0A2I2V1P8
names: Similarity
messages: Belongs to the PPP phosphatase family.

9685:MTMR12
gene id: 9685:MTMR12
uniprot id: A0A5F5Y132
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Sarcoplasmic reticulum
messages: sarcomere

9685:LOC101080886
gene id: 9685:LOC101080886
uniprot id: M3XAW8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:ESRRB
gene id: 9685:ESRRB
uniprot id: A0A5F5Y5D6
uniprot id: M3WAK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9685:COA3
gene id: 9685:COA3
uniprot id: M3WIA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9685:LOC101091348
gene id: 9685:LOC101091348
uniprot id: A0A2I2U2J9
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9685:DEFB127
gene id: 9685:DEFB127
uniprot id: A0A2I2UI37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9685:ALG10
gene id: 9685:ALG10
uniprot id: M3XFR9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:FAM83C
gene id: 9685:FAM83C
uniprot id: M3W5W6
names: Similarity
messages: Belongs to the FAM83 family.

9685:GDPD1
gene id: 9685:GDPD1
uniprot id: A0A2I2UXR5
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9685:LOC101087005
gene id: 9685:LOC101087005
uniprot id: A0A2I2U891
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SYNDIG1L
gene id: 9685:SYNDIG1L
uniprot id: M3W5S5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9685:PREP
gene id: 9685:PREP
uniprot id: M3W3E3
names: Similarity
messages: Belongs to the peptidase S9A family.

9685:TRABD2B
gene id: 9685:TRABD2B
uniprot id: M3WQ16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9685:KCNK16
gene id: 9685:KCNK16
uniprot id: M3W5V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9685:LOC101093045
gene id: 9685:LOC101093045
uniprot id: A0A2I2USS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC105259687
gene id: 9685:LOC105259687
uniprot id: A0A337RVC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RAF1
gene id: 9685:RAF1
uniprot id: A0A2I2UIN3
uniprot id: M3XB73
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9685:LOC101093519
gene id: 9685:LOC101093519
uniprot id: M3WY36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:LOC101091338
gene id: 9685:LOC101091338
uniprot id: M3WBG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CDKL4
gene id: 9685:CDKL4
uniprot id: M3X6A6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:YPEL4
gene id: 9685:YPEL4
uniprot id: A0A2I2V302
names: Similarity
messages: Belongs to the yippee family.

9685:PIGB
gene id: 9685:PIGB
uniprot id: M3XDS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9685:C7
gene id: 9685:C7
uniprot id: M3XAV7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:TOLLIP
gene id: 9685:TOLLIP
uniprot id: M3VZP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9685:ANXA3
gene id: 9685:ANXA3
uniprot id: M3WET7
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9685:RPS6KA5
gene id: 9685:RPS6KA5
uniprot id: M3VWX0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9685:OSBPL10
gene id: 9685:OSBPL10
uniprot id: M3W8W3
names: Similarity
messages: Belongs to the OSBP family.

9685:GET3
gene id: 9685:GET3
uniprot id: M3VUU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9685:HOXC5
gene id: 9685:HOXC5
uniprot id: A0A2I2UXE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9685:LOC101089195
gene id: 9685:LOC101089195
uniprot id: A0A337S9P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PREPL
gene id: 9685:PREPL
uniprot id: A0A5F5XLQ5
uniprot id: M3VV38
names: Similarity
messages: Belongs to the peptidase S9A family.

9685:PRNP
gene id: 9685:PRNP
uniprot id: B2LVH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane

9685:G6PC1
gene id: 9685:G6PC1
uniprot id: Q19KA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane
messages: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.

9685:FARSA
gene id: 9685:FARSA
uniprot id: A0A337SST7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

9685:LOC102902259
gene id: 9685:LOC102902259
uniprot id: A0A5F5XZ56
names: Similarity
messages: Belongs to the MS4A family.

9685:B3GNT3
gene id: 9685:B3GNT3
uniprot id: A0A337SI96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:CFAP299
gene id: 9685:CFAP299
uniprot id: M3WXK8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

9685:SQSTM1
gene id: 9685:SQSTM1
uniprot id: M3WL63
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9685:NBL1
gene id: 9685:NBL1
uniprot id: A0A2I2UVF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9685:FAM3C
gene id: 9685:FAM3C
uniprot id: M3WVJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9685:MRPS26
gene id: 9685:MRPS26
uniprot id: M3X130
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9685:PIK3C3
gene id: 9685:PIK3C3
uniprot id: M3XFX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

9685:TM4SF4
gene id: 9685:TM4SF4
uniprot id: A0A2I2UAR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9685:LYVE1
gene id: 9685:LYVE1
uniprot id: M3VUP6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:GPR158
gene id: 9685:GPR158
uniprot id: A0A2I2U5L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9685:AP2A1
gene id: 9685:AP2A1
uniprot id: A0A2I2U4V1
uniprot id: M3W262
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9685:LOC101097798
gene id: 9685:LOC101097798
uniprot id: A0A2I2USR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:NPFFR2
gene id: 9685:NPFFR2
uniprot id: M3WWS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9685:SLC34A1
gene id: 9685:SLC34A1
uniprot id: M3VWU4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9685:LOC101091384
gene id: 9685:LOC101091384
uniprot id: A0A2I2UFU6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9685:FELCATV1R3
gene id: 9685:FELCATV1R3
uniprot id: M3X6N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:PAF1
gene id: 9685:PAF1
uniprot id: M3WDU4
names: Similarity
messages: Belongs to the PAF1 family.

9685:MTRF1L
gene id: 9685:MTRF1L
uniprot id: A0A2I2U1A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9685:CLDN20
gene id: 9685:CLDN20
uniprot id: M3VXB2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:TAC1
gene id: 9685:TAC1
uniprot id: A0A337S4S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9685:PPM1B
gene id: 9685:PPM1B
uniprot id: A0A2I2UN37
uniprot id: M3WYG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9685:TAGLN
gene id: 9685:TAGLN
uniprot id: M3WJ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

9685:OSBPL9
gene id: 9685:OSBPL9
uniprot id: A0A337S5J8
uniprot id: M3WD14
names: Similarity
messages: Belongs to the OSBP family.

9685:SERPINF1
gene id: 9685:SERPINF1
uniprot id: M3W5N1
names: Similarity
messages: Belongs to the serpin family.

9685:CYSTM1
gene id: 9685:CYSTM1
uniprot id: A0A5F5XS44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

9685:ATAT1
gene id: 9685:ATAT1
uniprot id: A0A2I2UZN6
uniprot id: A0A337S138
uniprot id: M3W861
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

9685:NDUFB4
gene id: 9685:NDUFB4
uniprot id: M3X3W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9685:TSFM
gene id: 9685:TSFM
uniprot id: M3X1M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

9685:CADM2
gene id: 9685:CADM2
uniprot id: A0A2I2UUH5
uniprot id: A0A337S526
names: Similarity
messages: Belongs to the nectin family.

9685:FUNDC1
gene id: 9685:FUNDC1
uniprot id: A0A2I2U0L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9685:FAP
gene id: 9685:FAP
uniprot id: M3X4T1
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9685:DZIP1L
gene id: 9685:DZIP1L
uniprot id: M3WL84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

9685:HOMEZ
gene id: 9685:HOMEZ
uniprot id: A0A2I2US91
names: Subcellular Location Annotation
messages: Nucleus

9685:SUSD2
gene id: 9685:SUSD2
uniprot id: M3WBD8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LOC101099477
gene id: 9685:LOC101099477
uniprot id: M3WZD7
names: Similarity
messages: Belongs to the intermediate filament family.

9685:ZFP69B
gene id: 9685:ZFP69B
uniprot id: A0A2I2V2F3
names: Subcellular Location Annotation
messages: Nucleus

9685:SAE1
gene id: 9685:SAE1
uniprot id: M3WUU9
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9685:VPS54
gene id: 9685:VPS54
uniprot id: A0A2I2V3Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

9685:MC4R
gene id: 9685:MC4R
uniprot id: M3W634
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9685:LOC101096931
gene id: 9685:LOC101096931
uniprot id: A0A337RX34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:ADAT2
gene id: 9685:ADAT2
uniprot id: M3WX78
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9685:IRF6
gene id: 9685:IRF6
uniprot id: A0A2I2U4A6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:DRC7
gene id: 9685:DRC7
uniprot id: M3W8B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

9685:UBL4A
gene id: 9685:UBL4A
uniprot id: M3X745
names: Subcellular Location Annotation
messages: cytosol

9685:KCNJ16
gene id: 9685:KCNJ16
uniprot id: M3XAF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9685:GIPC2
gene id: 9685:GIPC2
uniprot id: A0A2I2UF05
names: Similarity
messages: Belongs to the GIPC family.

9685:STEAP2
gene id: 9685:STEAP2
uniprot id: M3WNS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9685:SSBP3
gene id: 9685:SSBP3
uniprot id: A0A2I2URT0
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101093190
gene id: 9685:LOC101093190
uniprot id: M3X6Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101088746
gene id: 9685:LOC101088746
uniprot id: M3X6T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:TVP23B
gene id: 9685:TVP23B
uniprot id: M3WRF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9685:RDH10
gene id: 9685:RDH10
uniprot id: M3WW26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9685:DUOXA2
gene id: 9685:DUOXA2
uniprot id: M3W7X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9685:LOC101083349
gene id: 9685:LOC101083349
uniprot id: M3WX52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:EME1
gene id: 9685:EME1
uniprot id: M3WGQ9
names: Similarity
messages: Belongs to the EME1/MMS4 family.

9685:CACNG3
gene id: 9685:CACNG3
uniprot id: M3WEG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9685:GJA8
gene id: 9685:GJA8
uniprot id: A0A5F5XUZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:TRPC1
gene id: 9685:TRPC1
uniprot id: M3WX01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9685:TMEM168
gene id: 9685:TMEM168
uniprot id: M3XE79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

9685:CLPS
gene id: 9685:CLPS
uniprot id: A0A337SLF4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9685:MRPL22
gene id: 9685:MRPL22
uniprot id: A0A2I2USF6
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9685:CYFIP1
gene id: 9685:CYFIP1
uniprot id: M3WIC1
names: Similarity
messages: Belongs to the CYFIP family.

9685:GIMAP6
gene id: 9685:GIMAP6
uniprot id: A0A337S2L7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9685:AMPD2
gene id: 9685:AMPD2
uniprot id: A0A337S5I4
uniprot id: A0A337STM7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9685:FEN1
gene id: 9685:FEN1
uniprot id: M3WJB0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9685:LOC101082667
gene id: 9685:LOC101082667
uniprot id: A0A5F5XDY1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9685:PSMC2
gene id: 9685:PSMC2
uniprot id: M3VV51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9685:P2RY2
gene id: 9685:P2RY2
uniprot id: A0A2I2UTD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:LOC101097811
gene id: 9685:LOC101097811
uniprot id: A0A5F5XT49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101095347
gene id: 9685:LOC101095347
uniprot id: M3WSM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:RPS3A
gene id: 9685:RPS3A
uniprot id: A0A0A0MQ24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9685:BAG6
gene id: 9685:BAG6
uniprot id: A0A2I2U5J3
uniprot id: A0A337S1C7
uniprot id: A0A337S510
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: extracellular exosome

9685:RDH11
gene id: 9685:RDH11
uniprot id: A0A5F5Y685
uniprot id: M3WK22
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:MARVELD3
gene id: 9685:MARVELD3
uniprot id: A0A337SP56
names: Subcellular Location Annotation
messages: Membrane

9685:SEPTIN9
gene id: 9685:SEPTIN9
uniprot id: A0A2I2UBG2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9685:THOC2
gene id: 9685:THOC2
uniprot id: A0A2I2UKV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

9685:CES1
gene id: 9685:CES1
uniprot id: Q766D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9685:TAS2R9
gene id: 9685:TAS2R9
uniprot id: M3W1M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9685:MOG
gene id: 9685:MOG
uniprot id: A0A337SU08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9685:CLCN2
gene id: 9685:CLCN2
uniprot id: A0A337SIW0
uniprot id: A0A5F5XF95
uniprot id: M3W8E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

9685:SMG9
gene id: 9685:SMG9
uniprot id: A0A337S2M1
names: Similarity
messages: Belongs to the SMG9 family.

9685:FAM219B
gene id: 9685:FAM219B
uniprot id: A0A2I2UJ08
names: Similarity
messages: Belongs to the FAM219 family.

9685:GJC3
gene id: 9685:GJC3
uniprot id: M3XE26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:MEIG1
gene id: 9685:MEIG1
uniprot id: M3X8F5
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9685:CD8B
gene id: 9685:CD8B
uniprot id: P79336
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked heterodimers with CD8A at the cell surface. Interacts with CD3D; this interaction couples TCR-CD3 with CD8. Interacts with LCK.
messages: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.
messages: Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.
messages: Phosphorylated as a consequence of T-cell activation.

9685:SHBG
gene id: 9685:SHBG
uniprot id: A0A5F5Y6V8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:TRIM3
gene id: 9685:TRIM3
uniprot id: A0A2I2U851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9685:LOC101082905
gene id: 9685:LOC101082905
uniprot id: A0A337RYZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9685:TFIP11
gene id: 9685:TFIP11
uniprot id: M3WUA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9685:ITIH2
gene id: 9685:ITIH2
uniprot id: A0A337SQW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9685:LOC101084226
gene id: 9685:LOC101084226
uniprot id: M3WQI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PHYHIP
gene id: 9685:PHYHIP
uniprot id: M3WSE3
names: Similarity
messages: Belongs to the PHYHIP family.

9685:BACE1
gene id: 9685:BACE1
uniprot id: M3VU83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: trans-Golgi network

9685:EDEM2
gene id: 9685:EDEM2
uniprot id: M3VYA1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9685:GAL3ST3
gene id: 9685:GAL3ST3
uniprot id: M3WIL0
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9685:MST1
gene id: 9685:MST1
uniprot id: A0A2I2UAP2
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:NMUR2
gene id: 9685:NMUR2
uniprot id: M3WGI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9685:LOC101082234
gene id: 9685:LOC101082234
uniprot id: M3XAR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CNPY1
gene id: 9685:CNPY1
uniprot id: A0A337SBZ2
names: Similarity
messages: Belongs to the canopy family.

9685:USP51
gene id: 9685:USP51
uniprot id: A0A5F5XDT6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9685:EPS8
gene id: 9685:EPS8
uniprot id: M3WSY6
names: Similarity
messages: Belongs to the EPS8 family.

9685:MSTN
gene id: 9685:MSTN
uniprot id: M3WPT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted

9685:TUBB2B
gene id: 9685:TUBB2B
uniprot id: A0A2I2UXF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9685:BORA
gene id: 9685:BORA
uniprot id: M3WCM8
names: Similarity
messages: Belongs to the BORA family.

9685:EIF3M
gene id: 9685:EIF3M
uniprot id: M3VUI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9685:TMEM165
gene id: 9685:TMEM165
uniprot id: A0A2I2U2M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

9685:SRP68
gene id: 9685:SRP68
uniprot id: M3W4N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9685:MVP
gene id: 9685:MVP
uniprot id: Q18PA2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9685:CLK2
gene id: 9685:CLK2
uniprot id: A0A2I2UHV8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:CEMIP2
gene id: 9685:CEMIP2
uniprot id: M3WDM4
names: Similarity
messages: Belongs to the CEMIP family.

9685:MRPS7
gene id: 9685:MRPS7
uniprot id: A0A2I2V1J0
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9685:OPRM1
gene id: 9685:OPRM1
uniprot id: M3W3Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

9685:BLM
gene id: 9685:BLM
uniprot id: M3W592
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9685:LOC101081667
gene id: 9685:LOC101081667
uniprot id: M3WQY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GAR1
gene id: 9685:GAR1
uniprot id: A0A337S3V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9685:TPRKB
gene id: 9685:TPRKB
uniprot id: A0A337RUZ9
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9685:ITPRIP
gene id: 9685:ITPRIP
uniprot id: A0A5F5XI11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Cell membrane
messages: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
messages: Membrane
messages: Nucleus outer membrane

9685:VARS1
gene id: 9685:VARS1
uniprot id: A0A337S2U8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9685:PDIK1L
gene id: 9685:PDIK1L
uniprot id: M3WZD8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:MED11
gene id: 9685:MED11
uniprot id: A0A2I2U581
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9685:CLCA2
gene id: 9685:CLCA2
uniprot id: M3W960
names: Similarity
messages: Belongs to the CLCR family.

9685:TMEM135
gene id: 9685:TMEM135
uniprot id: A0A337SCC1
uniprot id: A0A5F5XBX8
uniprot id: M3X3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane
messages: Peroxisome membrane

9685:ERCC4
gene id: 9685:ERCC4
uniprot id: M3W1H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9685:B2M
gene id: 9685:B2M
uniprot id: Q5MGS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

9685:RBBP7
gene id: 9685:RBBP7
uniprot id: M3X1K3
names: Subcellular Location Annotation
messages: Nucleus

9685:BMPR2
gene id: 9685:BMPR2
uniprot id: M3WK25
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9685:ING3
gene id: 9685:ING3
uniprot id: M3X266
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9685:ATG13
gene id: 9685:ATG13
uniprot id: A0A2I2U5Y7
uniprot id: A0A2I2ULX5
uniprot id: M3WJ75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9685:GDE1
gene id: 9685:GDE1
uniprot id: M3XBX5
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9685:KCNJ2
gene id: 9685:KCNJ2
uniprot id: K4LND8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

9685:CLRN3
gene id: 9685:CLRN3
uniprot id: A0A2I2UNK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9685:ZFPL1
gene id: 9685:ZFPL1
uniprot id: M3W5J7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

9685:DENR
gene id: 9685:DENR
uniprot id: A0A2I2UPJ8
names: Similarity
messages: Belongs to the DENR family.

9685:LOC101089384
gene id: 9685:LOC101089384
uniprot id: A0A5F5XXQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:BEX5
gene id: 9685:BEX5
uniprot id: M3WI51
names: Similarity
messages: Belongs to the BEX family.

9685:LOC101085463
gene id: 9685:LOC101085463
uniprot id: M3X6T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:EIF3G
gene id: 9685:EIF3G
uniprot id: M3WBC3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9685:TAS2R1
gene id: 9685:TAS2R1
uniprot id: M3WH93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9685:NR1H4
gene id: 9685:NR1H4
uniprot id: A0A2I2U1J3
uniprot id: M3W5Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9685:LOC101101588
gene id: 9685:LOC101101588
uniprot id: M3W476
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:EMC3
gene id: 9685:EMC3
uniprot id: M3WUY6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9685:EGF
gene id: 9685:EGF
uniprot id: Q95ND4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
messages: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity). Interacts with RHBDF2 (By similarity).
messages: Membrane

9685:TSEN2
gene id: 9685:TSEN2
uniprot id: A0A2I2UT31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9685:CHMP2A
gene id: 9685:CHMP2A
uniprot id: M3W0W8
names: Similarity
messages: Belongs to the SNF7 family.

9685:CCND1
gene id: 9685:CCND1
uniprot id: M3W9G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9685:DLST
gene id: 9685:DLST
uniprot id: M3W5T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9685:SLC5A1
gene id: 9685:SLC5A1
uniprot id: E1AWN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9685:VCP
gene id: 9685:VCP
uniprot id: M3VW05
names: Similarity
messages: Belongs to the AAA ATPase family.

9685:CD37
gene id: 9685:CD37
uniprot id: M3VWB3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:ANTXR1
gene id: 9685:ANTXR1
uniprot id: A0A337SQH5
uniprot id: M3W804
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9685:POMT1
gene id: 9685:POMT1
uniprot id: A0A5F5XZ91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9685:PATL1
gene id: 9685:PATL1
uniprot id: M3WMV5
names: Similarity
messages: Belongs to the PAT1 family.

9685:TFAP2B
gene id: 9685:TFAP2B
uniprot id: A0A2I2U397
uniprot id: A0A2I2UT09
uniprot id: M3WMP4
names: Similarity
messages: Belongs to the AP-2 family.

9685:LOC101082261
gene id: 9685:LOC101082261
uniprot id: M3XB67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SHKBP1
gene id: 9685:SHKBP1
uniprot id: M3VVW3
names: Similarity
messages: Belongs to the KCTD3 family.

9685:LOC101097701
gene id: 9685:LOC101097701
uniprot id: A0A2I2V3M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9685:FAM229B
gene id: 9685:FAM229B
uniprot id: M3WVH7
names: Similarity
messages: Belongs to the FAM229 family.

9685:CTSB
gene id: 9685:CTSB
uniprot id: M3WLU0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9685:PRPF4B
gene id: 9685:PRPF4B
uniprot id: M3X311
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

9685:LGI1
gene id: 9685:LGI1
uniprot id: A0A2I2ULQ8
uniprot id: A0A2I2V1N8
uniprot id: A0A337S1Y9
names: Subcellular Location Annotation
messages: Secreted

9685:CDKL1
gene id: 9685:CDKL1
uniprot id: M3WU63
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:SCNN1G
gene id: 9685:SCNN1G
uniprot id: M3W3L6
names: Subcellular Location Annotation
messages: Membrane

9685:CDK2AP2
gene id: 9685:CDK2AP2
uniprot id: A0A337SBV5
names: Similarity
messages: Belongs to the CDK2AP family.

9685:BEX2
gene id: 9685:BEX2
uniprot id: M3W135
names: Similarity
messages: Belongs to the BEX family.

9685:YKT6
gene id: 9685:YKT6
uniprot id: M3WKK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9685:PER1
gene id: 9685:PER1
uniprot id: M3WM49
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9685:NDRG3
gene id: 9685:NDRG3
uniprot id: A0A2I2UN34
uniprot id: A0A2I2UPL8
names: Similarity
messages: Belongs to the NDRG family.

9685:NPC2
gene id: 9685:NPC2
uniprot id: M3X1L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9685:ADH5
gene id: 9685:ADH5
uniprot id: M3W3A3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9685:GPAT4
gene id: 9685:GPAT4
uniprot id: A0A337SQZ9
uniprot id: M3WHX9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9685:ERBB2
gene id: 9685:ERBB2
uniprot id: Q49LT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9685:AMY2B
gene id: 9685:AMY2B
uniprot id: M3X5H0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9685:MC1R
gene id: 9685:MC1R
uniprot id: Q7YSE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9685:PSMD3
gene id: 9685:PSMD3
uniprot id: M3WLR0
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9685:IDUA
gene id: 9685:IDUA
uniprot id: A0A097HWG4
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

9685:IL6
gene id: 9685:IL6
uniprot id: P41683
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).
messages: Secreted

9685:ACTR2
gene id: 9685:ACTR2
uniprot id: A0A2I2UP96
uniprot id: M3W369
names: Similarity
messages: Belongs to the actin family.

9685:LOC101101025
gene id: 9685:LOC101101025
uniprot id: A0A5F5XJU1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:DHODH
gene id: 9685:DHODH
uniprot id: M3WTW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9685:SLC6A13
gene id: 9685:SLC6A13
uniprot id: A0A5F5XLK7
uniprot id: M3WKI9
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Membrane

9685:LOC101080990
gene id: 9685:LOC101080990
uniprot id: A0A337RTK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9685:DRD3
gene id: 9685:DRD3
uniprot id: A0A5F5XXG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9685:SLC9C2
gene id: 9685:SLC9C2
uniprot id: M3WMD3
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9685:AGBL5
gene id: 9685:AGBL5
uniprot id: A0A5F5XS39
uniprot id: A0A5F5XY69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Midbody
messages: Nucleus
messages: cytosol
messages: spindle

9685:LOC101083714
gene id: 9685:LOC101083714
uniprot id: M3VWT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9685:MRPS23
gene id: 9685:MRPS23
uniprot id: M3W4J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

9685:LOC101086986
gene id: 9685:LOC101086986
uniprot id: A0A337S8F5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

9685:CLDN12
gene id: 9685:CLDN12
uniprot id: M3X2V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9685:LAMB1
gene id: 9685:LAMB1
uniprot id: M3W292
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9685:CHRND
gene id: 9685:CHRND
uniprot id: M3W4H9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:CNPY2
gene id: 9685:CNPY2
uniprot id: M3WG69
names: Similarity
messages: Belongs to the canopy family.

9685:SNCG
gene id: 9685:SNCG
uniprot id: M3W8Q2
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

9685:ERLIN2
gene id: 9685:ERLIN2
uniprot id: M3WMT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9685:STAG2
gene id: 9685:STAG2
uniprot id: A0A2I2UUV0
uniprot id: A0A337ST49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9685:UCP3
gene id: 9685:UCP3
uniprot id: M3W3C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:TMEM126A
gene id: 9685:TMEM126A
uniprot id: M3WQ15
names: Subcellular Location Annotation
messages: Membrane

9685:HMGN3
gene id: 9685:HMGN3
uniprot id: A0A337SCE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
messages: Nucleus

9685:HOXA2
gene id: 9685:HOXA2
uniprot id: M3W8N8
names: Subcellular Location Annotation
messages: Nucleus

9685:P3H2
gene id: 9685:P3H2
uniprot id: M3VVE5
names: Similarity
messages: Belongs to the leprecan family.

9685:PICALM
gene id: 9685:PICALM
uniprot id: M3XEB8
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9685:KATNAL1
gene id: 9685:KATNAL1
uniprot id: A0A2I2V0H9
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9685:HTRA2
gene id: 9685:HTRA2
uniprot id: M3W782
names: Similarity
messages: Belongs to the peptidase S1C family.

9685:BRIX1
gene id: 9685:BRIX1
uniprot id: A0A2I2UF52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9685:PEX3
gene id: 9685:PEX3
uniprot id: M3XD19
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9685:DOLK
gene id: 9685:DOLK
uniprot id: M3X6P1
names: Similarity
messages: Belongs to the polyprenol kinase family.

9685:NNAT
gene id: 9685:NNAT
uniprot id: A0A2I2ULK2
names: Similarity
messages: Belongs to the neuronatin family.

9685:PTPN3
gene id: 9685:PTPN3
uniprot id: M3WE86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9685:NPL
gene id: 9685:NPL
uniprot id: A0A337S5Y4
uniprot id: M3WR24
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9685:BANP
gene id: 9685:BANP
uniprot id: M3WYK1
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9685:MRPL53
gene id: 9685:MRPL53
uniprot id: A0A2I2U9A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

9685:PCOLCE
gene id: 9685:PCOLCE
uniprot id: A0A5F5XK05
uniprot id: M3W6K9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:SERPINB10
gene id: 9685:SERPINB10
uniprot id: M3W9H4
names: Similarity
messages: Belongs to the serpin family.

9685:PAX7
gene id: 9685:PAX7
uniprot id: A0A337SMJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9685:EDNRA
gene id: 9685:EDNRA
uniprot id: M3WMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9685:LOC101100398
gene id: 9685:LOC101100398
uniprot id: A0A337S8G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:HDAC1
gene id: 9685:HDAC1
uniprot id: A0A2I2ULD8
uniprot id: A0A2I2UTS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9685:SDC1
gene id: 9685:SDC1
uniprot id: M3W3X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane
messages: extracellular exosome

9685:CYP26A1
gene id: 9685:CYP26A1
uniprot id: M3W7D6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9685:TGM6
gene id: 9685:TGM6
uniprot id: M3WKQ7
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9685:ACTR1A
gene id: 9685:ACTR1A
uniprot id: M3VWA6
names: Similarity
messages: Belongs to the actin family.

9685:CASTOR1
gene id: 9685:CASTOR1
uniprot id: M3WG12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

9685:DENND10
gene id: 9685:DENND10
uniprot id: M3WDN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

9685:PPP2R5A
gene id: 9685:PPP2R5A
uniprot id: M3X5Y6
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9685:TLCD1
gene id: 9685:TLCD1
uniprot id: M3W1E9
names: Subcellular Location Annotation
messages: Membrane

9685:TRAK1
gene id: 9685:TRAK1
uniprot id: A0A337SDJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9685:AGBL3
gene id: 9685:AGBL3
uniprot id: M3WUM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9685:ATP6V0C
gene id: 9685:ATP6V0C
uniprot id: A0A5F5XUE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9685:NAGPA
gene id: 9685:NAGPA
uniprot id: M3W2G0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CLDN3
gene id: 9685:CLDN3
uniprot id: A0A337S9C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:SLC35E3
gene id: 9685:SLC35E3
uniprot id: M3WKG7
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101088902
gene id: 9685:LOC101088902
uniprot id: A0A2I2UVG5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9685:EDIL3
gene id: 9685:EDIL3
uniprot id: A0A2I2U3E6
uniprot id: M3VYL7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:TREX1
gene id: 9685:TREX1
uniprot id: M3X2S3
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9685:PALS1
gene id: 9685:PALS1
uniprot id: M3WEF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: tight junction

9685:LOC101100954
gene id: 9685:LOC101100954
uniprot id: A0A2I2UDK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9685:RTN4
gene id: 9685:RTN4
uniprot id: A0A337SH78
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:TUBGCP3
gene id: 9685:TUBGCP3
uniprot id: M3W0Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9685:PPARG
gene id: 9685:PPARG
uniprot id: A0A337SSZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9685:PIK3CD
gene id: 9685:PIK3CD
uniprot id: M3XAA6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9685:MID1
gene id: 9685:MID1
uniprot id: M3VYS6
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

9685:TCEAL1
gene id: 9685:TCEAL1
uniprot id: M3X2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: Nucleus

9685:NPPB
gene id: 9685:NPPB
uniprot id: Q9GLK4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity).
messages: Secreted
messages: The precursor molecule is proteolytically cleaved, possibly by FURIN or CORIN, to produce the active peptide (By similarity). May undergo further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (By similarity). May be cleaved at Ser-102 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (By similarity). May be degraded by IDE (By similarity). During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (By similarity).

9685:ATXN1
gene id: 9685:ATXN1
uniprot id: M3WEU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9685:DPYSL2
gene id: 9685:DPYSL2
uniprot id: A0A2I2UQR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

9685:SF3B6
gene id: 9685:SF3B6
uniprot id: M3X5D4
names: Subcellular Location Annotation
messages: Nucleus

9685:POLR2I
gene id: 9685:POLR2I
uniprot id: M3X8K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9685:MS4A3
gene id: 9685:MS4A3
uniprot id: A0A2I2UGY8
uniprot id: A0A337SUC4
names: Similarity
messages: Belongs to the MS4A family.

9685:BCL2L11
gene id: 9685:BCL2L11
uniprot id: A0A337SPG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Bcl-2 family.
messages: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.
messages: Induces apoptosis and anoikis.

9685:HSD17B12
gene id: 9685:HSD17B12
uniprot id: M3XF85
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:PKM
gene id: 9685:PKM
uniprot id: A0A337S4I7
names: Similarity
messages: Belongs to the pyruvate kinase family.

9685:PHACTR4
gene id: 9685:PHACTR4
uniprot id: M3WIT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9685:TLR2
gene id: 9685:TLR2
uniprot id: M3X0I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides.
messages: Membrane
messages: Membrane raft
messages: phagosome membrane

9685:RETREG1
gene id: 9685:RETREG1
uniprot id: A0A2I2URS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9685:LAMTOR3
gene id: 9685:LAMTOR3
uniprot id: A0A2I2U2H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9685:PRPF19
gene id: 9685:PRPF19
uniprot id: M3WJ97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9685:SMPD1
gene id: 9685:SMPD1
uniprot id: M3X374
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

9685:GTF2H4
gene id: 9685:GTF2H4
uniprot id: M3WNZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9685:ILDR1
gene id: 9685:ILDR1
uniprot id: M3WA36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9685:LOC101101393
gene id: 9685:LOC101101393
uniprot id: M3X1G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101088440
gene id: 9685:LOC101088440
uniprot id: M3WZS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9685:FAM167A
gene id: 9685:FAM167A
uniprot id: A0A2I2UR49
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9685:DZIP3
gene id: 9685:DZIP3
uniprot id: A0A5F5XKN4
uniprot id: A0A5F5XLB4
names: Subcellular Location Annotation
messages: Cytoplasm

9685:NPR3
gene id: 9685:NPR3
uniprot id: M3W032
names: Subcellular Location Annotation
messages: Membrane

9685:LSM5
gene id: 9685:LSM5
uniprot id: M3X1T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9685:PEX19
gene id: 9685:PEX19
uniprot id: M3W181
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9685:PCSK1
gene id: 9685:PCSK1
uniprot id: M3W5Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9685:OSBPL1A
gene id: 9685:OSBPL1A
uniprot id: A0A5F5XMP9
uniprot id: A0A5F5XTE9
names: Similarity
messages: Belongs to the OSBP family.

9685:CA7
gene id: 9685:CA7
uniprot id: M3WHK2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9685:DDX41
gene id: 9685:DDX41
uniprot id: M3VWU8
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

9685:CD3E
gene id: 9685:CD3E
uniprot id: Q5R1Q1
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6. Interacts with NCK1. Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation.

9685:RPRD1B
gene id: 9685:RPRD1B
uniprot id: M3X7W3
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9685:SPACA3
gene id: 9685:SPACA3
uniprot id: A0A077S1K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Interacts with ASTL.
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.

9685:CLRN1
gene id: 9685:CLRN1
uniprot id: M3WD68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9685:PRKAG1
gene id: 9685:PRKAG1
uniprot id: A0A2I2UK65
names: Similarity
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.

9685:CCT8
gene id: 9685:CCT8
uniprot id: A0A2I2U221
uniprot id: M3WNF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

9685:KITLG
gene id: 9685:KITLG
uniprot id: P79169
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.
messages: Belongs to the SCF family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Secreted
messages: Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity).
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9685:NDUFAF7
gene id: 9685:NDUFAF7
uniprot id: M3WN86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9685:ITGB1
gene id: 9685:ITGB1
uniprot id: P53713
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Cell surface
messages: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, …
messages: Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner (By similarity). Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB, FLNC and RANBP9. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with MYO10. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with DAB2. Interacts with FGR and HCK. Isoform 2 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 2 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (By similarity). ITGA5:ITGB1 interacts with CCN3 (By similarity). ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (By similarity). ITGA5:ITGB1 interacts with FBN1 (By similarity). ITGA5:ITGB1 interacts with IL1B. Interacts with MDK. ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation. ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outg…
messages: Melanosome
messages: Recycling endosome
messages: The cysteine residues are involved in intrachain disulfide bonds.
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle
messages: ruffle membrane

9685:MAPK6
gene id: 9685:MAPK6
uniprot id: M3WH68
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9685:CDH20
gene id: 9685:CDH20
uniprot id: M3VZV0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9685:LOC101093295
gene id: 9685:LOC101093295
uniprot id: M3XG15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:NR2C1
gene id: 9685:NR2C1
uniprot id: M3X424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9685:LOC101101352
gene id: 9685:LOC101101352
uniprot id: M3WH90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IGFL family.
messages: Secreted

9685:LLPH
gene id: 9685:LLPH
uniprot id: M3X158
names: Similarity
messages: Belongs to the learning-associated protein family.

9685:GAST
gene id: 9685:GAST
uniprot id: A0A0A0MQ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9685:LOC101092267
gene id: 9685:LOC101092267
uniprot id: M3X6T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:RPTOR
gene id: 9685:RPTOR
uniprot id: A0A337RX48
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9685:CACNA2D1
gene id: 9685:CACNA2D1
uniprot id: A0A2I2UTD9
uniprot id: A0A337SUK1
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9685:CREBL2
gene id: 9685:CREBL2
uniprot id: M3X0E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9685:SULT1B1
gene id: 9685:SULT1B1
uniprot id: M3W895
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9685:LOC101087594
gene id: 9685:LOC101087594
uniprot id: A0A337SSJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9685:CLUAP1
gene id: 9685:CLUAP1
uniprot id: A0A2I2ULU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9685:ATP7A
gene id: 9685:ATP7A
uniprot id: M3WS99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9685:TAX1BP3
gene id: 9685:TAX1BP3
uniprot id: A0A2I2U8E9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9685:HSF4
gene id: 9685:HSF4
uniprot id: M3WK27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9685:MED28
gene id: 9685:MED28
uniprot id: M3WXV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9685:CCT2
gene id: 9685:CCT2
uniprot id: M3VWY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9685:LOC101099980
gene id: 9685:LOC101099980
uniprot id: A0A2I2U3J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MAPK8
gene id: 9685:MAPK8
uniprot id: A0A2I2V255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9685:RPF1
gene id: 9685:RPF1
uniprot id: M3WXF9
names: Subcellular Location Annotation
messages: nucleolus

9685:FELCATV1R13
gene id: 9685:FELCATV1R13
uniprot id: M3XCI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:SLC25A24
gene id: 9685:SLC25A24
uniprot id: M3VW64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9685:HACD3
gene id: 9685:HACD3
uniprot id: M3WA17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:NCK1
gene id: 9685:NCK1
uniprot id: A0A2I2UF94
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9685:CDH3
gene id: 9685:CDH3
uniprot id: A0A2I2UB75
uniprot id: M3VVY0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9685:VASP
gene id: 9685:VASP
uniprot id: M3W7Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9685:P2RX3
gene id: 9685:P2RX3
uniprot id: A0A337S2N6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9685:ARHGEF9
gene id: 9685:ARHGEF9
uniprot id: A0A2I2UV58
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
messages: Cytoplasm
messages: Interacts with GPHN.
messages: Postsynaptic density

9685:SH3KBP1
gene id: 9685:SH3KBP1
uniprot id: A0A2I2UEU6
uniprot id: A0A337S1J4
names: Subcellular Location Annotation
messages: focal adhesion

9685:EIF3D
gene id: 9685:EIF3D
uniprot id: M3VW18
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9685:TBC1D7
gene id: 9685:TBC1D7
uniprot id: A0A337SET6
uniprot id: M3WKW9
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9685:ANKRD34B
gene id: 9685:ANKRD34B
uniprot id: M3X2M2
names: Similarity
messages: Belongs to the ANKRD34 family.

9685:PIGC
gene id: 9685:PIGC
uniprot id: M3XAC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9685:VPS29
gene id: 9685:VPS29
uniprot id: A0A337SIK8
uniprot id: M3W1M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9685:NFRKB
gene id: 9685:NFRKB
uniprot id: M3W1L1
names: Subcellular Location Annotation
messages: Nucleus

9685:DST
gene id: 9685:DST
uniprot id: A0A337ST32
uniprot id: M3XAY2
names: Subcellular Location Annotation
messages: cytoskeleton

9685:TIMM44
gene id: 9685:TIMM44
uniprot id: M3WLN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

9685:ADGRG5
gene id: 9685:ADGRG5
uniprot id: A0A337S790
names: Subcellular Location Annotation
messages: Membrane

9685:FGF18
gene id: 9685:FGF18
uniprot id: M3W721
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9685:ORMDL3
gene id: 9685:ORMDL3
uniprot id: M3X8M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

9685:GJA1
gene id: 9685:GJA1
uniprot id: M3X8Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:MFSD14A
gene id: 9685:MFSD14A
uniprot id: M3X3C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9685:LIMK2
gene id: 9685:LIMK2
uniprot id: A0A2I2UJQ8
uniprot id: M3VWF3
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9685:LOC101089279
gene id: 9685:LOC101089279
uniprot id: M3WVT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC554344
gene id: 9685:LOC554344
uniprot id: Q5KR53
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9685:RIOK3
gene id: 9685:RIOK3
uniprot id: M3VUX4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

9685:EIF3J
gene id: 9685:EIF3J
uniprot id: A0A337SFB5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9685:LOC101082692
gene id: 9685:LOC101082692
uniprot id: M3WSK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ZSCAN16
gene id: 9685:ZSCAN16
uniprot id: A0A5F5Y1L6
uniprot id: M3W0N4
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101097721
gene id: 9685:LOC101097721
uniprot id: A0A337SKR4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:NCF2
gene id: 9685:NCF2
uniprot id: M3X0B4
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9685:FABP7
gene id: 9685:FABP7
uniprot id: M3W635
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9685:ENKUR
gene id: 9685:ENKUR
uniprot id: A0A2I2USE4
names: Subcellular Location Annotation
messages: cilium axoneme

9685:CFAP97D1
gene id: 9685:CFAP97D1
uniprot id: M3X8Y6
names: Similarity
messages: Belongs to the CFAP97 family.

9685:AASDH
gene id: 9685:AASDH
uniprot id: A0A2I2UUF5
uniprot id: M3W654
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9685:SCAMP4
gene id: 9685:SCAMP4
uniprot id: A0A2I2U1D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9685:FGF21
gene id: 9685:FGF21
uniprot id: A0A7U3JWC1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9685:SHMT1
gene id: 9685:SHMT1
uniprot id: M3WMK4
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9685:CLTCL1
gene id: 9685:CLTCL1
uniprot id: M3WZ57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9685:NIBAN2
gene id: 9685:NIBAN2
uniprot id: M3VWQ9
names: Similarity
messages: Belongs to the Niban family.

9685:MFN2
gene id: 9685:MFN2
uniprot id: M3VU19
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9685:LOC101101145
gene id: 9685:LOC101101145
uniprot id: M3XG37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CNN3
gene id: 9685:CNN3
uniprot id: M3WLX8
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9685:TUBA4A
gene id: 9685:TUBA4A
uniprot id: A0A2I2UZ20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9685:CCDC47
gene id: 9685:CCDC47
uniprot id: M3X4U5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Rough endoplasmic reticulum membrane

9685:POLR1C
gene id: 9685:POLR1C
uniprot id: M3WC04
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9685:IRF1
gene id: 9685:IRF1
uniprot id: M3WIN1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:EFEMP1
gene id: 9685:EFEMP1
uniprot id: M3VVE6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:PLAC8L1
gene id: 9685:PLAC8L1
uniprot id: M3WA37
names: Similarity
messages: Belongs to the cornifelin family.

9685:PTH
gene id: 9685:PTH
uniprot id: Q9GL67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
messages: Secreted

9685:GINS1
gene id: 9685:GINS1
uniprot id: A0A2I2UG70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9685:ADRB2
gene id: 9685:ADRB2
uniprot id: Q9TST5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity).
messages: Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (By similarity). Interacts with USP20 and USP33 (By similarity). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4 (By similarity). Interacts with MARCHF2 (By similarity).
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
messages: Palmitoylated. Mainly palmitoylated at Cys-341. Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi. Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor. Could be depalmitoylated by LYPLA1 at the plasma membrane.
messages: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity).
messages: Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
messages: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
messages: Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity).

9685:LOC101095283
gene id: 9685:LOC101095283
uniprot id: A0A337RZH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101094321
gene id: 9685:LOC101094321
uniprot id: A0A5F5XJY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SERPINA11
gene id: 9685:SERPINA11
uniprot id: M3WCX2
names: Similarity
messages: Belongs to the serpin family.

9685:RRM1
gene id: 9685:RRM1
uniprot id: M3W8F8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9685:HSPB8
gene id: 9685:HSPB8
uniprot id: M3XDU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9685:CLDN7
gene id: 9685:CLDN7
uniprot id: M3WXP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:SLA
gene id: 9685:SLA
uniprot id: A0A2I2U783
names: Subcellular Location Annotation
messages: Cytoplasm

9685:SRSF4
gene id: 9685:SRSF4
uniprot id: A0A5F5Y1F6
names: Similarity
messages: Belongs to the splicing factor SR family.

9685:PORCN
gene id: 9685:PORCN
uniprot id: A0A337S7I9
uniprot id: A0A337SGW0
names: Subcellular Location Annotation
messages: Membrane

9685:PADI6
gene id: 9685:PADI6
uniprot id: A1A438
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9685:UGDH
gene id: 9685:UGDH
uniprot id: M3WBQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9685:KYAT3
gene id: 9685:KYAT3
uniprot id: M3W8I7
names: Subunit
messages: Homodimer.

9685:FKBP6
gene id: 9685:FKBP6
uniprot id: M3WHD0
names: Function
names: Similarity
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

9685:LOC101099942
gene id: 9685:LOC101099942
uniprot id: M3XEU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CDKN2AIPNL
gene id: 9685:CDKN2AIPNL
uniprot id: A0A2I2UUV8
names: Similarity
messages: Belongs to the CARF family.

9685:LOC101095042
gene id: 9685:LOC101095042
uniprot id: M3XB96
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ZDHHC21
gene id: 9685:ZDHHC21
uniprot id: M3W6D1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:GAP43
gene id: 9685:GAP43
uniprot id: Q6S9D9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts (via IQ domain) with calmodulin (By similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).
messages: Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity).
messages: Perikaryon
messages: Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9685:EFHC1
gene id: 9685:EFHC1
uniprot id: M3WF69
names: Subcellular Location Annotation
messages: cilium axoneme

9685:CENPX
gene id: 9685:CENPX
uniprot id: A0A337SG66
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

9685:NDUFV2
gene id: 9685:NDUFV2
uniprot id: A0A337RZR2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9685:FLVCR2
gene id: 9685:FLVCR2
uniprot id: M3WK96
names: Subcellular Location Annotation
messages: Membrane

9685:CMKLR2
gene id: 9685:CMKLR2
uniprot id: M3WTW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9685:CC1H1orf52
gene id: 9685:CC1H1orf52
uniprot id: A0A2I2UYD1
names: Similarity
messages: Belongs to the UPF0690 family.

9685:VAMP5
gene id: 9685:VAMP5
uniprot id: M3WU54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9685:SLC47A1
gene id: 9685:SLC47A1
uniprot id: M3WFX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9685:NTS
gene id: 9685:NTS
uniprot id: M3X5C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9685:CREB3L2
gene id: 9685:CREB3L2
uniprot id: M3VV60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9685:MVB12A
gene id: 9685:MVB12A
uniprot id: A0A337SL83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9685:USP1
gene id: 9685:USP1
uniprot id: M3X7I7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9685:PIGN
gene id: 9685:PIGN
uniprot id: A0A2I2U8X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

9685:LOC101096314
gene id: 9685:LOC101096314
uniprot id: M3WZR5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:NUBP2
gene id: 9685:NUBP2
uniprot id: A0A2I2UA39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9685:SEC61B
gene id: 9685:SEC61B
uniprot id: M3WGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9685:PFN4
gene id: 9685:PFN4
uniprot id: M3W1Z0
names: Similarity
messages: Belongs to the profilin family.

9685:MAP2
gene id: 9685:MAP2
uniprot id: A0A2I2UEF9
uniprot id: M3XEW5
names: Subcellular Location Annotation
messages: cytoskeleton

9685:KARS1
gene id: 9685:KARS1
uniprot id: A0A2I2UD22
uniprot id: M3W9U6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9685:EPG5
gene id: 9685:EPG5
uniprot id: M3WDP9
names: Similarity
messages: Belongs to the EPG5 family.

9685:CLIC1
gene id: 9685:CLIC1
uniprot id: M3WNY6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9685:CRHR1
gene id: 9685:CRHR1
uniprot id: A0A337SCM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
messages: Membrane

9685:SLC13A1
gene id: 9685:SLC13A1
uniprot id: A0A337SGW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9685:KEF43 p02
gene id: 9685:KEF43_p02
uniprot id: A0A0R8CB67
uniprot id: P48926
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9685:CD40LG
gene id: 9685:CD40LG
uniprot id: O97605
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9685:PARP14
gene id: 9685:PARP14
uniprot id: M3XBX0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9685:LOC101100947
gene id: 9685:LOC101100947
uniprot id: M3X7H4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9685:TRUB1
gene id: 9685:TRUB1
uniprot id: M3WVR4
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9685:GH1
gene id: 9685:GH1
uniprot id: P46404
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9685:FN3KRP
gene id: 9685:FN3KRP
uniprot id: M3WFV8
names: Similarity
messages: Belongs to the fructosamine kinase family.

9685:CYP21A2
gene id: 9685:CYP21A2
uniprot id: Q2LA60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
messages: The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane.

9685:IMPDH2
gene id: 9685:IMPDH2
uniprot id: M3WC84
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9685:LOC101082235
gene id: 9685:LOC101082235
uniprot id: M3X6T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:RPS27L
gene id: 9685:RPS27L
uniprot id: A0A2I2UEY8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9685:TDGF1
gene id: 9685:TDGF1
uniprot id: M3WKU3
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:GPX8
gene id: 9685:GPX8
uniprot id: M3X4H0
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9685:MEGF8
gene id: 9685:MEGF8
uniprot id: A0A337RYD6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:GGPS1
gene id: 9685:GGPS1
uniprot id: M3W9L8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9685:SNX7
gene id: 9685:SNX7
uniprot id: A0A2I2UIZ1
names: Similarity
messages: Belongs to the sorting nexin family.

9685:TMOD3
gene id: 9685:TMOD3
uniprot id: M3WH67
names: Subcellular Location Annotation
messages: cytoskeleton

9685:SF3B1
gene id: 9685:SF3B1
uniprot id: M3W3C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9685:ARSB
gene id: 9685:ARSB
uniprot id: P33727
names: Activity Regulation
names: Cofactor
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Defects in ARSB are the cause of mucopolysaccharidosis type VI (MPS-VI). MPS-VI has been described in Siamese cats (PubMed:6794375).
messages: Homodimer.
messages: Inhibited by ethanol (By similarity).
messages: Lysosome
messages: Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9685:CSNK2A1
gene id: 9685:CSNK2A1
uniprot id: A0A337SK77
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:AVPR1B
gene id: 9685:AVPR1B
uniprot id: M3W6E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9685:MCEE
gene id: 9685:MCEE
uniprot id: A0A2I2UYE6
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9685:LOC101092643
gene id: 9685:LOC101092643
uniprot id: A0A2I2V115
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PSMD4
gene id: 9685:PSMD4
uniprot id: A0A2I2V018
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9685:MIOX
gene id: 9685:MIOX
uniprot id: M3WI29
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

9685:DEFB134
gene id: 9685:DEFB134
uniprot id: A0A2I2UIQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9685:HHIPL2
gene id: 9685:HHIPL2
uniprot id: M3VY61
names: Similarity
messages: Belongs to the HHIP family.

9685:DCN
gene id: 9685:DCN
uniprot id: M3X0W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

9685:ATP6V0D1
gene id: 9685:ATP6V0D1
uniprot id: A0A337SG88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9685:GEM
gene id: 9685:GEM
uniprot id: A0A2I2UE29
uniprot id: M3WMR8
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9685:MED24
gene id: 9685:MED24
uniprot id: M3WLR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9685:ATP5MC1
gene id: 9685:ATP5MC1
uniprot id: M3VYC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9685:OXTR
gene id: 9685:OXTR
uniprot id: M3WL83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9685:GMNN
gene id: 9685:GMNN
uniprot id: M3WRI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9685:STX12
gene id: 9685:STX12
uniprot id: M3X2I4
names: Similarity
messages: Belongs to the syntaxin family.

9685:LNPK
gene id: 9685:LNPK
uniprot id: A0A2I2U439
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9685:IRF2
gene id: 9685:IRF2
uniprot id: A0A2I2UD66
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:HIBADH
gene id: 9685:HIBADH
uniprot id: M3X8B5
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9685:ASCC3
gene id: 9685:ASCC3
uniprot id: M3X4E0
names: Similarity
messages: Belongs to the helicase family.

9685:CAMLG
gene id: 9685:CAMLG
uniprot id: M3XG72
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9685:CHAT
gene id: 9685:CHAT
uniprot id: A0A2I2U4U6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9685:SCARB2
gene id: 9685:SCARB2
uniprot id: M3VW08
names: Similarity
messages: Belongs to the CD36 family.

9685:LOC101096439
gene id: 9685:LOC101096439
uniprot id: A0A2I2UWE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9685:STK10
gene id: 9685:STK10
uniprot id: M3VUR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane

9685:GSKIP
gene id: 9685:GSKIP
uniprot id: A0A2I2UQ57
names: Similarity
messages: Belongs to the GSKIP family.

9685:TNNI3
gene id: 9685:TNNI3
uniprot id: Q863B6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the troponin I family.
messages: Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1 (By similarity).
messages: Phosphorylated at Ser-22 and Ser-23 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity).
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9685:DYNLRB1
gene id: 9685:DYNLRB1
uniprot id: M3VY92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9685:CYB5A
gene id: 9685:CYB5A
uniprot id: M3X9M9
names: Similarity
messages: Belongs to the cytochrome b5 family.

9685:MAPRE3
gene id: 9685:MAPRE3
uniprot id: A0A2I2UGV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9685:HBM
gene id: 9685:HBM
uniprot id: M3WAU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9685:RFC4
gene id: 9685:RFC4
uniprot id: M3WJN5
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9685:PRPF3
gene id: 9685:PRPF3
uniprot id: A0A5F5XYH3
uniprot id: M3WJS5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9685:UBLCP1
gene id: 9685:UBLCP1
uniprot id: A0A337SD56
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9685:LOC101099668
gene id: 9685:LOC101099668
uniprot id: A0A5F5XLY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MED30
gene id: 9685:MED30
uniprot id: M3X2K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9685:OSBPL8
gene id: 9685:OSBPL8
uniprot id: A0A2I2UHJ1
names: Similarity
messages: Belongs to the OSBP family.

9685:MLN
gene id: 9685:MLN
uniprot id: Q9XSE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

9685:LOC101093986
gene id: 9685:LOC101093986
uniprot id: A0A2I2UEY8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9685:EPS8L3
gene id: 9685:EPS8L3
uniprot id: M3WMX1
names: Similarity
messages: Belongs to the EPS8 family.

9685:BOK
gene id: 9685:BOK
uniprot id: M3WKE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9685:GNB1
gene id: 9685:GNB1
uniprot id: M3WU86
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9685:ANAPC16
gene id: 9685:ANAPC16
uniprot id: A0A2I2UKW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9685:MICOS13
gene id: 9685:MICOS13
uniprot id: M3WFV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9685:LOC101096317
gene id: 9685:LOC101096317
uniprot id: M3W3Q0
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9685:IL1B
gene id: 9685:IL1B
uniprot id: P41687
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling. Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form. Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC. Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9685:MRPS25
gene id: 9685:MRPS25
uniprot id: M3X9W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9685:SCGN
gene id: 9685:SCGN
uniprot id: M3WL42
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9685:TRMT10C
gene id: 9685:TRMT10C
uniprot id: M3XBQ3
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9685:MYH7
gene id: 9685:MYH7
uniprot id: M3WAS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9685:UNC5C
gene id: 9685:UNC5C
uniprot id: A0A2I2UWZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9685:PRL
gene id: 9685:PRL
uniprot id: P46403
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the somatotropin/prolactin family.
messages: Interacts with PRLR.
messages: Prolactin acts primarily on the mammary gland by promoting lactation.
messages: Secreted

9685:GBA3
gene id: 9685:GBA3
uniprot id: A0A2I2UCJ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9685:LOC101094786
gene id: 9685:LOC101094786
uniprot id: A0A5F5XQ16
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ZSCAN31
gene id: 9685:ZSCAN31
uniprot id: A0A5F5XMM8
uniprot id: M3VUC4
names: Subcellular Location Annotation
messages: Nucleus

9685:BROX
gene id: 9685:BROX
uniprot id: A0A5F5XRG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BROX family.
messages: Membrane

9685:NCBP3
gene id: 9685:NCBP3
uniprot id: A0A5F5XYG5
names: Similarity
messages: Belongs to the NCBP3 family.

9685:HS2ST1
gene id: 9685:HS2ST1
uniprot id: A0A5F5XX19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9685:PPEF1
gene id: 9685:PPEF1
uniprot id: A0A2I2U5S1
names: Similarity
messages: Belongs to the PPP phosphatase family.

9685:KCNK5
gene id: 9685:KCNK5
uniprot id: M3XCY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9685:ARAP3
gene id: 9685:ARAP3
uniprot id: M3XBA3
names: Subcellular Location Annotation
messages: Cytoplasm

9685:MFSD6
gene id: 9685:MFSD6
uniprot id: M3W3M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9685:OST4
gene id: 9685:OST4
uniprot id: A0A337S2V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:HOXA3
gene id: 9685:HOXA3
uniprot id: M3X946
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9685:NIT2
gene id: 9685:NIT2
uniprot id: M3XFS6
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9685:CE3H16orf91
gene id: 9685:CE3H16orf91
uniprot id: A0A2I2UBE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCSMST1 family.
messages: Membrane

9685:DPM2
gene id: 9685:DPM2
uniprot id: M3WRG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9685:PRORP
gene id: 9685:PRORP
uniprot id: M3W232
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9685:RAD1
gene id: 9685:RAD1
uniprot id: A0A2I2U9S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9685:GUSB
gene id: 9685:GUSB
uniprot id: O97524
names: Activity Regulation
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Defects in GUSB are the cause of mucopolysaccharidosis type VII (MPS VII), an inherited disease reported in humans, mice, cats, and dogs.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

9685:TMEM121B
gene id: 9685:TMEM121B
uniprot id: A0A5F5XVV8
names: Similarity
messages: Belongs to the TMEM121 family.

9685:KRT39
gene id: 9685:KRT39
uniprot id: M3VXR5
names: Similarity
messages: Belongs to the intermediate filament family.

9685:CDH12
gene id: 9685:CDH12
uniprot id: M3W8Q0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9685:DOC2A
gene id: 9685:DOC2A
uniprot id: A0A5F5XIJ7
names: Subcellular Location Annotation
messages: Membrane

9685:DOCK4
gene id: 9685:DOCK4
uniprot id: A0A2I2UVR6
uniprot id: M3WHB8
names: Similarity
messages: Belongs to the DOCK family.

9685:AMBP
gene id: 9685:AMBP
uniprot id: E1CJT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9685:MTIF2
gene id: 9685:MTIF2
uniprot id: M3WJ66
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9685:FXN
gene id: 9685:FXN
uniprot id: M3X7T9
names: Similarity
messages: Belongs to the frataxin family.

9685:PRPS1
gene id: 9685:PRPS1
uniprot id: A0A337SDM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9685:CD28
gene id: 9685:CD28
uniprot id: Q9N2I4
names: Subcellular Location Annotation
messages: Membrane

9685:SLC26A10
gene id: 9685:SLC26A10
uniprot id: M3X126
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:MARVELD2
gene id: 9685:MARVELD2
uniprot id: M3XBR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9685:ZNF274
gene id: 9685:ZNF274
uniprot id: A0A5F5Y3C6
uniprot id: M3X6Y2
names: Subcellular Location Annotation
messages: Nucleus

9685:DCLRE1C
gene id: 9685:DCLRE1C
uniprot id: A0A2I2UH99
uniprot id: M3XCG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9685:DDX52
gene id: 9685:DDX52
uniprot id: M3WDI8
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9685:POLA2
gene id: 9685:POLA2
uniprot id: M3VWM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

9685:SBDS
gene id: 9685:SBDS
uniprot id: M3X604
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9685:ANAPC13
gene id: 9685:ANAPC13
uniprot id: M3X5A0
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9685:PPP2R2A
gene id: 9685:PPP2R2A
uniprot id: A0A2I2UVM7
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9685:FAR2
gene id: 9685:FAR2
uniprot id: M3VUC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9685:DYNLL1
gene id: 9685:DYNLL1
uniprot id: A0A2I2UY49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9685:ZDHHC7
gene id: 9685:ZDHHC7
uniprot id: M3X5E5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:RPL35A
gene id: 9685:RPL35A
uniprot id: A0A337SK14
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9685:SLC10A2
gene id: 9685:SLC10A2
uniprot id: M3W5V2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

9685:NRG1
gene id: 9685:NRG1
uniprot id: A0A2I2UUU7
uniprot id: A0A337SJX3
uniprot id: A0A5F5XW86
uniprot id: M3WRB1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9685:GJE1
gene id: 9685:GJE1
uniprot id: A0A337SPI7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:DTX3
gene id: 9685:DTX3
uniprot id: M3VXV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9685:EIF4G1
gene id: 9685:EIF4G1
uniprot id: M3W8E0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9685:PSMG2
gene id: 9685:PSMG2
uniprot id: M3W4P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9685:LOC101099246
gene id: 9685:LOC101099246
uniprot id: M3XF49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TSEN34
gene id: 9685:TSEN34
uniprot id: M3WJZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9685:PSAT1
gene id: 9685:PSAT1
uniprot id: M3X3I1
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

9685:UQCRQ
gene id: 9685:UQCRQ
uniprot id: M3X026
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9685:PPP2R2B
gene id: 9685:PPP2R2B
uniprot id: A0A2I2UC36
uniprot id: A0A2I2UDT3
uniprot id: A0A2I2V279
uniprot id: A0A337S301
uniprot id: A0A337SI73
uniprot id: M3WCM2
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9685:CDK8
gene id: 9685:CDK8
uniprot id: M3WW64
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:DERL1
gene id: 9685:DERL1
uniprot id: M3XA42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9685:LOC101089059
gene id: 9685:LOC101089059
uniprot id: A0A2I2UWZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9685:LOC101088096
gene id: 9685:LOC101088096
uniprot id: A0A2I2UA77
names: Similarity
messages: Belongs to the LCE family.

9685:IL6ST
gene id: 9685:IL6ST
uniprot id: M3WE28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9685:POLR2H
gene id: 9685:POLR2H
uniprot id: M3W8E3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9685:PSMA2
gene id: 9685:PSMA2
uniprot id: M3XAA2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9685:GABRA3
gene id: 9685:GABRA3
uniprot id: M3WNK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:MRPL12
gene id: 9685:MRPL12
uniprot id: M3WHW8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9685:KDM4A
gene id: 9685:KDM4A
uniprot id: M3WLZ4
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9685:ACER2
gene id: 9685:ACER2
uniprot id: M3VYQ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:TUB
gene id: 9685:TUB
uniprot id: M3VVA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9685:CD164
gene id: 9685:CD164
uniprot id: A0A2I2UX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9685:MTCH2
gene id: 9685:MTCH2
uniprot id: M3X0I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:CBR3
gene id: 9685:CBR3
uniprot id: A0A2I2UQU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9685:CASP7
gene id: 9685:CASP7
uniprot id: A0A2I2UIV2
names: Similarity
messages: Belongs to the peptidase C14A family.

9685:CSTF1
gene id: 9685:CSTF1
uniprot id: M3X8P0
names: Subcellular Location Annotation
messages: Nucleus

9685:ADCY7
gene id: 9685:ADCY7
uniprot id: M3X5P3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9685:CPLANE2
gene id: 9685:CPLANE2
uniprot id: A0A2I2U005
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9685:ELAPOR1
gene id: 9685:ELAPOR1
uniprot id: M3WM91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9685:ERLEC1
gene id: 9685:ERLEC1
uniprot id: A0A337S9P7
uniprot id: M3WIQ5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9685:PANX3
gene id: 9685:PANX3
uniprot id: M3VYU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9685:LOC101095121
gene id: 9685:LOC101095121
uniprot id: M3WD92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:OGT
gene id: 9685:OGT
uniprot id: A0A2I2UCU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9685:EPS8L1
gene id: 9685:EPS8L1
uniprot id: M3X4X2
names: Similarity
messages: Belongs to the EPS8 family.

9685:PDCD10
gene id: 9685:PDCD10
uniprot id: M3X9Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9685:DARS1
gene id: 9685:DARS1
uniprot id: A0A5F5Y2Y4
uniprot id: M3WKG0
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9685:MAB21L1
gene id: 9685:MAB21L1
uniprot id: M3WXW7
names: Similarity
messages: Belongs to the mab-21 family.

9685:TOMM7
gene id: 9685:TOMM7
uniprot id: A0A337S2F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9685:CCL5
gene id: 9685:CCL5
uniprot id: Q8SQ40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
messages: Secreted

9685:CRY1
gene id: 9685:CRY1
uniprot id: M3XE84
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9685:ANAPC5
gene id: 9685:ANAPC5
uniprot id: M3WGZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9685:CLASP1
gene id: 9685:CLASP1
uniprot id: A0A337SQX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: centrosome
messages: kinetochore
messages: trans-Golgi network

9685:NOX4
gene id: 9685:NOX4
uniprot id: M3XET3
names: Subcellular Location Annotation
messages: Membrane

9685:PAMR1
gene id: 9685:PAMR1
uniprot id: M3W4X3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:ETNPPL
gene id: 9685:ETNPPL
uniprot id: A0A2I2V1A7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9685:ELF1
gene id: 9685:ELF1
uniprot id: M3WV46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:PBX1
gene id: 9685:PBX1
uniprot id: A0A5F5XPX1
uniprot id: A0A5F5XTL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9685:RAB39A
gene id: 9685:RAB39A
uniprot id: A0A2I2UQL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9685:RIBC1
gene id: 9685:RIBC1
uniprot id: M3WJP5
names: Similarity
messages: Belongs to the RIB43A family.

9685:CH2
gene id: 9685:CH2
uniprot id: P30440
names: Allergen
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the secretoglobin family.
messages: Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.
messages: Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.
messages: Secreted
messages: The long form is preferentially expressed in the salivary gland, while the short form is preferentially expressed in the skin.

9685:SLC14A2
gene id: 9685:SLC14A2
uniprot id: A0A5F5XWY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9685:HMGN4
gene id: 9685:HMGN4
uniprot id: M3WMG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9685:LOC101086721
gene id: 9685:LOC101086721
uniprot id: M3WY36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:LOC101100752
gene id: 9685:LOC101100752
uniprot id: A0A337SWS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:IDH1
gene id: 9685:IDH1
uniprot id: M3W1B8
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9685:CTTNBP2
gene id: 9685:CTTNBP2
uniprot id: A0M8T5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.
messages: Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
messages: cell cortex
messages: dendritic spine

9685:DYNLT3
gene id: 9685:DYNLT3
uniprot id: A0A337SD65
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9685:LOC101100940
gene id: 9685:LOC101100940
uniprot id: M3W153
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PABIR2
gene id: 9685:PABIR2
uniprot id: A0A5F5XKZ8
uniprot id: A0A5F5XLV6
uniprot id: A0A5F5XSY8
uniprot id: M3W2G3
uniprot id: M3X693
names: Similarity
messages: Belongs to the FAM122 family.

9685:SLC50A1
gene id: 9685:SLC50A1
uniprot id: M3XFN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9685:PLBD1
gene id: 9685:PLBD1
uniprot id: M3WDG7
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9685:LOC101098667
gene id: 9685:LOC101098667
uniprot id: M3X3R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LGI4
gene id: 9685:LGI4
uniprot id: A0A2Z5XVT7
names: Subcellular Location Annotation
messages: Secreted

9685:ITGB7
gene id: 9685:ITGB7
uniprot id: M3W4V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9685:TP53
gene id: 9685:TP53
uniprot id: A0A059UCX8
uniprot id: P41685
names: Cofactor
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of Lys-375 by CREBBP enhances transcriptional activity. Acetylation of Lys-375 by EP300. Deacetylation of Lys-375 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-374 increases stability. Deacetylation at Lys-374 by SIRT6 decreases its stability, thereby regulating cell senescence.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-375) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interactio…
messages: Mitochondrion matrix
messages: Monomethylated at Lys-365 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-363 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-365 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-363. Dimethylated at Lys-366 by EHMT1 and EHMT2. Monomethylated at Lys-375 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-363 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-326 and dimethylated at Arg-328 and Arg-330 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).
messages: Nucleus
messages: PML body
messages: Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-385 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-385 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).
messages: Sumoylated with SUMO1. Sumoylated at Lys-379 by UBC9 (By similarity).
messages: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
messages: Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity).
messages: centrosome
messages: p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.

9685:G6PC3
gene id: 9685:G6PC3
uniprot id: M3VY26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9685:PSPH
gene id: 9685:PSPH
uniprot id: A0A337SAC2
uniprot id: M3WT54
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

9685:SRM
gene id: 9685:SRM
uniprot id: M3WN08
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9685:PDE10A
gene id: 9685:PDE10A
uniprot id: A0A2I2UWU4
uniprot id: A0A337SUW8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9685:MRPL49
gene id: 9685:MRPL49
uniprot id: A0A337SFG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

9685:PGBD1
gene id: 9685:PGBD1
uniprot id: A0A2I2UEW8
names: Subcellular Location Annotation
messages: Nucleus

9685:DYNC1LI1
gene id: 9685:DYNC1LI1
uniprot id: M3W8M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9685:DPM3
gene id: 9685:DPM3
uniprot id: M3WRQ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

9685:SLC39A9
gene id: 9685:SLC39A9
uniprot id: A0A2I2UTH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

9685:PACC1
gene id: 9685:PACC1
uniprot id: M3WL04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9685:CHD6
gene id: 9685:CHD6
uniprot id: M3W0K5
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9685:GPR17
gene id: 9685:GPR17
uniprot id: M3WIC9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:TLR1
gene id: 9685:TLR1
uniprot id: A0A5F5XZ29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9685:TNRC6B
gene id: 9685:TNRC6B
uniprot id: A0A2I2V342
names: Similarity
messages: Belongs to the GW182 family.

9685:LOC101095768
gene id: 9685:LOC101095768
uniprot id: M3X512
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LIN9
gene id: 9685:LIN9
uniprot id: A0A5F5XSF8
names: Similarity
messages: Belongs to the lin-9 family.

9685:NDRG2
gene id: 9685:NDRG2
uniprot id: A0A337SPG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

9685:SERPING1
gene id: 9685:SERPING1
uniprot id: M3W683
names: Similarity
messages: Belongs to the serpin family.

9685:PHF1
gene id: 9685:PHF1
uniprot id: A0A337S4E6
uniprot id: A0A5F5Y057
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9685:CYP2R1
gene id: 9685:CYP2R1
uniprot id: M3WF06
names: Similarity
messages: Belongs to the cytochrome P450 family.

9685:CCNY
gene id: 9685:CCNY
uniprot id: M3XBP5
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9685:SLC33A1
gene id: 9685:SLC33A1
uniprot id: M3X228
names: Subcellular Location Annotation
messages: Membrane

9685:SH3BP5L
gene id: 9685:SH3BP5L
uniprot id: M3X7J8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9685:EPHA6
gene id: 9685:EPHA6
uniprot id: A0A337SR05
names: Subcellular Location Annotation
messages: Membrane

9685:RENBP
gene id: 9685:RENBP
uniprot id: M3WNP8
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

9685:MLH3
gene id: 9685:MLH3
uniprot id: M3X1R3
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9685:MYO1D
gene id: 9685:MYO1D
uniprot id: M3WGW9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9685:COPB2
gene id: 9685:COPB2
uniprot id: M3VWP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

9685:KCNE3
gene id: 9685:KCNE3
uniprot id: M3W8P2
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9685:TMEFF2
gene id: 9685:TMEFF2
uniprot id: A0A2I2UBW6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:NCAPD3
gene id: 9685:NCAPD3
uniprot id: A0A337S6P0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

9685:KEF43 p09
gene id: 9685:KEF43_p09
uniprot id: P48896
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrion membrane

9685:GRIN2A
gene id: 9685:GRIN2A
uniprot id: M3WKG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9685:TEX10
gene id: 9685:TEX10
uniprot id: A0A2I2UWT5
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9685:CFTR
gene id: 9685:CFTR
uniprot id: A0M8T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.
messages: Recycling endosome membrane

9685:GAL3ST4
gene id: 9685:GAL3ST4
uniprot id: M3X9U2
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9685:MAP3K8
gene id: 9685:MAP3K8
uniprot id: M3W239
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9685:SULT1C3
gene id: 9685:SULT1C3
uniprot id: M3X2S6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9685:TPM3
gene id: 9685:TPM3
uniprot id: A0A2I2UNA8
uniprot id: A0A337S6S4
uniprot id: A0A337SR60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9685:SAT1
gene id: 9685:SAT1
uniprot id: A0A2I2UEI2
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Homodimer.

9685:RPL36AL
gene id: 9685:RPL36AL
uniprot id: M3WWJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9685:ZRANB1
gene id: 9685:ZRANB1
uniprot id: A0A2I2URP9
names: Similarity
messages: Belongs to the peptidase C64 family.

9685:BTN1A1
gene id: 9685:BTN1A1
uniprot id: M3WR01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9685:COQ7
gene id: 9685:COQ7
uniprot id: M3WJK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9685:LIPA
gene id: 9685:LIPA
uniprot id: A0A5F5XPV2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9685:MAGOH
gene id: 9685:MAGOH
uniprot id: M3X9V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9685:CDKN2AIP
gene id: 9685:CDKN2AIP
uniprot id: M3WU69
names: Similarity
messages: Belongs to the CARF family.

9685:TGM5
gene id: 9685:TGM5
uniprot id: A0A2I2UM78
uniprot id: A0A2I2UX75
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9685:ARFGEF1
gene id: 9685:ARFGEF1
uniprot id: M3WMT3
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9685:LOC101098543
gene id: 9685:LOC101098543
uniprot id: M3X3H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CYP11A1
gene id: 9685:CYP11A1
uniprot id: M3WE36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Interacts with FDX1/adrenodoxin.
messages: Mitochondrion inner membrane

9685:COPS2
gene id: 9685:COPS2
uniprot id: A0A337SLC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

9685:MCM2
gene id: 9685:MCM2
uniprot id: M3WJ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9685:RFTN1
gene id: 9685:RFTN1
uniprot id: M3WU48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9685:TRAF4
gene id: 9685:TRAF4
uniprot id: M3W1F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9685:PPIP5K1
gene id: 9685:PPIP5K1
uniprot id: A0A2I2UZU1
uniprot id: A0A5F5XGZ1
uniprot id: A0A5F5XRT4
uniprot id: A0A5F5XW90
uniprot id: M3W1T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9685:GPR34
gene id: 9685:GPR34
uniprot id: A0A5F5XBZ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:DIABLO
gene id: 9685:DIABLO
uniprot id: A0A2I2UKG3
names: Subcellular Location Annotation
messages: Mitochondrion

9685:IFRD1
gene id: 9685:IFRD1
uniprot id: M3X558
names: Similarity
messages: Belongs to the IFRD family.

9685:STK4
gene id: 9685:STK4
uniprot id: M3WYH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9685:ZC2HC1C
gene id: 9685:ZC2HC1C
uniprot id: A0A5F5XZF1
uniprot id: M3W5T2
names: Similarity
messages: Belongs to the ZC2HC1 family.

9685:NDUFA11
gene id: 9685:NDUFA11
uniprot id: M3WND4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9685:RPA1
gene id: 9685:RPA1
uniprot id: M3W5N4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

9685:IL12B
gene id: 9685:IL12B
uniprot id: O02744
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Secreted

9685:LIN7B
gene id: 9685:LIN7B
uniprot id: M3WP58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9685:RPS13
gene id: 9685:RPS13
uniprot id: A0A2I2U4A9
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9685:RTN1
gene id: 9685:RTN1
uniprot id: A0A337S7R8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:KRT84
gene id: 9685:KRT84
uniprot id: M3VUF7
names: Similarity
messages: Belongs to the intermediate filament family.

9685:ADCK1
gene id: 9685:ADCK1
uniprot id: A0A2I2UZL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Secreted

9685:PPP1R3C
gene id: 9685:PPP1R3C
uniprot id: M3WBI3
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9685:KIF3A
gene id: 9685:KIF3A
uniprot id: A0A2I2U4Q8
uniprot id: M3WJY9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:RBCK1
gene id: 9685:RBCK1
uniprot id: A0A2I2UKQ6
names: Similarity
messages: Belongs to the RBR family.

9685:CUTA
gene id: 9685:CUTA
uniprot id: A0A2I2UJG2
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9685:FHL5
gene id: 9685:FHL5
uniprot id: M3WQD7
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9685:PIGW
gene id: 9685:PIGW
uniprot id: M3WSJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

9685:SLC27A5
gene id: 9685:SLC27A5
uniprot id: M3W0W6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9685:RPL32
gene id: 9685:RPL32
uniprot id: M3WW95
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9685:FAM161B
gene id: 9685:FAM161B
uniprot id: M3WGJ6
names: Similarity
messages: Belongs to the FAM161 family.

9685:FUBP1
gene id: 9685:FUBP1
uniprot id: A0A337S9W3
names: Subcellular Location Annotation
messages: Nucleus

9685:ACO2
gene id: 9685:ACO2
uniprot id: M3WP87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

9685:FAM234A
gene id: 9685:FAM234A
uniprot id: M3WAU7
names: Similarity
messages: Belongs to the FAM234 family.

9685:COPS7B
gene id: 9685:COPS7B
uniprot id: A0A337SR29
uniprot id: M3X9M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9685:NEUROD1
gene id: 9685:NEUROD1
uniprot id: M3W2E4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9685:AFF1
gene id: 9685:AFF1
uniprot id: A0A5F5XXG3
names: Similarity
messages: Belongs to the AF4 family.

9685:RIMKLB
gene id: 9685:RIMKLB
uniprot id: A0A2I2UKB4
names: Similarity
messages: Belongs to the RimK family.

9685:AVL9
gene id: 9685:AVL9
uniprot id: M3W850
names: Subcellular Location Annotation
messages: Endosome
messages: Recycling endosome

9685:LOC101084174
gene id: 9685:LOC101084174
uniprot id: A0A2I2URS3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:UGT8
gene id: 9685:UGT8
uniprot id: M3WVI1
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9685:RELT
gene id: 9685:RELT
uniprot id: M3VZA9
names: Similarity
messages: Belongs to the RELT family.

9685:SHCBP1
gene id: 9685:SHCBP1
uniprot id: M3WFS8
names: Subcellular Location Annotation
messages: spindle

9685:UNC45A
gene id: 9685:UNC45A
uniprot id: M3W599
names: Subcellular Location Annotation
messages: perinuclear region

9685:DENND6B
gene id: 9685:DENND6B
uniprot id: M3WG02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

9685:MYADM
gene id: 9685:MYADM
uniprot id: M3WYP6
names: Subcellular Location Annotation
messages: Membrane

9685:LEP
gene id: 9685:LEP
uniprot id: Q9N2C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP…
messages: Secreted

9685:SERINC2
gene id: 9685:SERINC2
uniprot id: A0A337S134
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9685:PMPCB
gene id: 9685:PMPCB
uniprot id: M3VV49
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Mitochondrion matrix

9685:MYOC
gene id: 9685:MYOC
uniprot id: Q594P2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell projection
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Expressed in optic nerve head, ciliary body and retina.
messages: Glycosylated.
messages: Golgi apparatus
messages: Homodimer (via N-terminus). Can also form higher oligomers. Interacts with OLFM3, FN1, NRCAM, GLDN and NFASC. Interacts (via N-terminus) with MYL2. Interacts with SFRP1, FRZB, FZD7, FZD10, FZD1 and WIF1; regulates Wnt signaling (By similarity). Interacts with SNTA1; regulates muscle hypertrophy. Interacts with ERBB2 and ERBB3; activates ERBB2-ERBB3 signaling pathway. Interacts with SNCG; affects its secretion and its aggregation (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion outer membrane
messages: Palmitoylated.
messages: Rough endoplasmic reticulum
messages: Secreted
messages: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.
messages: Undergoes a calcium-dependent proteolytic cleavage at Arg-212 by CAPN2 in the endoplasmic reticulum. The result is the production of two fragments, one of 35 kDa containing the C-terminal olfactomedin-like domain, and another of 20 kDa containing the N-terminal leucine zipper-like domain (By similarity).
messages: cilium
messages: extracellular exosome
messages: extracellular matrix
messages: extracellular space

9685:BEST2
gene id: 9685:BEST2
uniprot id: M3VUU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9685:TRIM36
gene id: 9685:TRIM36
uniprot id: A0A2I2UWQ5
names: Subcellular Location Annotation
messages: cytoskeleton

9685:ARSJ
gene id: 9685:ARSJ
uniprot id: A0A2I2U9Q5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9685:ITIH1
gene id: 9685:ITIH1
uniprot id: M3WN59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9685:PDC
gene id: 9685:PDC
uniprot id: P41686
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosducin family.
messages: Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.
messages: Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.
messages: Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.
messages: Nucleus
messages: Photoreceptor inner segment
messages: cytosol
messages: photoreceptor outer segment

9685:ATG9B
gene id: 9685:ATG9B
uniprot id: M3WIE1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9685:SNRPB
gene id: 9685:SNRPB
uniprot id: A0A2I2V053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9685:ACOT8
gene id: 9685:ACOT8
uniprot id: M3VXG9
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9685:FSHB
gene id: 9685:FSHB
uniprot id: M3WL17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9685:CREB3L4
gene id: 9685:CREB3L4
uniprot id: M3WH79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:DCTN1
gene id: 9685:DCTN1
uniprot id: A0A2I2UNT0
uniprot id: A0A2I2UWJ5
uniprot id: A0A337SCA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

9685:SLC41A1
gene id: 9685:SLC41A1
uniprot id: M3X7L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9685:NUDT2
gene id: 9685:NUDT2
uniprot id: M3X650
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9685:VDAC2
gene id: 9685:VDAC2
uniprot id: M3X2J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Mitochondrion outer membrane

9685:SLC25A17
gene id: 9685:SLC25A17
uniprot id: A0A2I2UYF3
uniprot id: M3WMM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:RNF141
gene id: 9685:RNF141
uniprot id: M3WTE2
names: Function
messages: May be involved in spermatogenesis.

9685:LOC101088485
gene id: 9685:LOC101088485
uniprot id: M3X6T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:CCN6
gene id: 9685:CCN6
uniprot id: A0A2I2UNS1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:DOK3
gene id: 9685:DOK3
uniprot id: M3X6K9
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9685:NEUROD4
gene id: 9685:NEUROD4
uniprot id: M3WIK7
names: Subcellular Location Annotation
messages: Nucleus

9685:FAM219A
gene id: 9685:FAM219A
uniprot id: A0A2I2U7R5
names: Similarity
messages: Belongs to the FAM219 family.

9685:NFYB
gene id: 9685:NFYB
uniprot id: A0A2I2U0F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9685:EGFLAM
gene id: 9685:EGFLAM
uniprot id: A0A2I2UEP2
uniprot id: M3WDB8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:ONECUT1
gene id: 9685:ONECUT1
uniprot id: M3W213
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9685:ARRDC1
gene id: 9685:ARRDC1
uniprot id: M3XEH2
names: Similarity
messages: Belongs to the arrestin family.

9685:LAMTOR2
gene id: 9685:LAMTOR2
uniprot id: M3XCQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9685:DIPK2A
gene id: 9685:DIPK2A
uniprot id: M3X2C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9685:ATF7IP
gene id: 9685:ATF7IP
uniprot id: M3WRU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9685:IFI6
gene id: 9685:IFI6
uniprot id: A0A2I2UFF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9685:CPSF7
gene id: 9685:CPSF7
uniprot id: A0A2I2UVT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9685:NUCB2
gene id: 9685:NUCB2
uniprot id: M3W7H2
names: Similarity
messages: Belongs to the nucleobindin family.

9685:STEAP1
gene id: 9685:STEAP1
uniprot id: M3X2G9
names: Subcellular Location Annotation
messages: Membrane

9685:RPL39
gene id: 9685:RPL39
uniprot id: A0A2I2UY38
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9685:MLLT11
gene id: 9685:MLLT11
uniprot id: M3WVR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9685:KCNK17
gene id: 9685:KCNK17
uniprot id: M3XBT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9685:COX18
gene id: 9685:COX18
uniprot id: M3WJS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9685:EYA3
gene id: 9685:EYA3
uniprot id: A0A2I2UQC1
uniprot id: A0A337S444
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9685:CSNK1A1
gene id: 9685:CSNK1A1
uniprot id: A0A2I2UKP0
uniprot id: M3X447
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:NCAM1
gene id: 9685:NCAM1
uniprot id: A0A337SS65
uniprot id: Q5G7G8
uniprot id: Q5R1Q0
names: Function
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

9685:APOM
gene id: 9685:APOM
uniprot id: M3W828
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9685:ADORA2A
gene id: 9685:ADORA2A
uniprot id: A0A5F5XV38
uniprot id: M3X6N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9685:SEMA3A
gene id: 9685:SEMA3A
uniprot id: A0A2I2U9R0
uniprot id: A0A2I2UVN1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:BMPR1B
gene id: 9685:BMPR1B
uniprot id: A0A2I2UWR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9685:TMEM229B
gene id: 9685:TMEM229B
uniprot id: A0A5F5Y1W9
uniprot id: M3XDR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9685:FIP1L1
gene id: 9685:FIP1L1
uniprot id: A0A2I2U5G5
uniprot id: A0A2I2UTP6
uniprot id: A0A337SM21
uniprot id: A0A5F5XZX8
uniprot id: M3WSP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9685:GPR108
gene id: 9685:GPR108
uniprot id: A0A5F5XJ50
names: Subcellular Location Annotation
messages: Membrane

9685:SLC13A5
gene id: 9685:SLC13A5
uniprot id: A0A2I2UNR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9685:MRPS12
gene id: 9685:MRPS12
uniprot id: A0A2I2UVJ6
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9685:CROT
gene id: 9685:CROT
uniprot id: M3X8A3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9685:GTF2A2
gene id: 9685:GTF2A2
uniprot id: A0A337SEM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9685:BBOX1
gene id: 9685:BBOX1
uniprot id: M3WKZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
messages: Cytoplasm

9685:PLEKHA8
gene id: 9685:PLEKHA8
uniprot id: M3VYG4
names: Subcellular Location Annotation
messages: Membrane
messages: trans-Golgi network membrane

9685:TXNRD1
gene id: 9685:TXNRD1
uniprot id: M3W0Q4
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

9685:ENO2
gene id: 9685:ENO2
uniprot id: A0A2I2UHT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9685:HDAC3
gene id: 9685:HDAC3
uniprot id: M3W6Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9685:B4GALT3
gene id: 9685:B4GALT3
uniprot id: M3WN80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9685:CCL17
gene id: 9685:CCL17
uniprot id: Q8I021
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity).
messages: Expressed in thymus and also in spleen, lung, lymph node, kidney, small intestine, colon and skin.
messages: Secreted

9685:PDCL
gene id: 9685:PDCL
uniprot id: M3X7C8
names: Similarity
messages: Belongs to the phosducin family.

9685:DGUOK
gene id: 9685:DGUOK
uniprot id: A0A337SML0
names: Similarity
messages: Belongs to the DCK/DGK family.

9685:CRABP2
gene id: 9685:CRABP2
uniprot id: M3WZX3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9685:HTR3E
gene id: 9685:HTR3E
uniprot id: M3W8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9685:CSTF3
gene id: 9685:CSTF3
uniprot id: M3WPX4
names: Subcellular Location Annotation
messages: Nucleus

9685:RNASE11
gene id: 9685:RNASE11
uniprot id: M3X7R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9685:LOC101100332
gene id: 9685:LOC101100332
uniprot id: M3WX64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CLNS1A
gene id: 9685:CLNS1A
uniprot id: M3XFV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9685:GPC4
gene id: 9685:GPC4
uniprot id: M3W6M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9685:RGS5
gene id: 9685:RGS5
uniprot id: M3VZD1
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9685:STOML3
gene id: 9685:STOML3
uniprot id: A0A337S9V5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9685:SLC25A25
gene id: 9685:SLC25A25
uniprot id: A0A2I2UAY0
uniprot id: M3VWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9685:LOC101085428
gene id: 9685:LOC101085428
uniprot id: A0A2I2UP08
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:HYAL2
gene id: 9685:HYAL2
uniprot id: A0A5F5Y3D4
uniprot id: M3W6X5
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9685:UBE3D
gene id: 9685:UBE3D
uniprot id: A0A2I2UAH8
uniprot id: M3WDJ3
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

9685:ACADSB
gene id: 9685:ACADSB
uniprot id: M3W0B5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9685:PGD
gene id: 9685:PGD
uniprot id: M3WKZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9685:MEIS1
gene id: 9685:MEIS1
uniprot id: A0A2I2UH05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9685:VPS33A
gene id: 9685:VPS33A
uniprot id: M3WQ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9685:SEC63
gene id: 9685:SEC63
uniprot id: M3VY59
names: Subcellular Location Annotation
messages: Membrane

9685:ANXA7
gene id: 9685:ANXA7
uniprot id: M3W9B7
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9685:PM20D2
gene id: 9685:PM20D2
uniprot id: M3WKB5
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.

9685:PALMD
gene id: 9685:PALMD
uniprot id: M3VVU7
names: Similarity
messages: Belongs to the paralemmin family.

9685:CTSD
gene id: 9685:CTSD
uniprot id: M3W8G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

9685:LOC101101377
gene id: 9685:LOC101101377
uniprot id: A0A2I2UHU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:NSA2
gene id: 9685:NSA2
uniprot id: M3WG45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9685:SLC4A4
gene id: 9685:SLC4A4
uniprot id: A0A2I2UF62
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:FMO1
gene id: 9685:FMO1
uniprot id: M3W9L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

9685:ABITRAM
gene id: 9685:ABITRAM
uniprot id: A0A2I2UZ38
uniprot id: A0A5F5XKS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9685:DCP1B
gene id: 9685:DCP1B
uniprot id: M3W2X1
names: Similarity
messages: Belongs to the DCP1 family.

9685:KIF5C
gene id: 9685:KIF5C
uniprot id: A0A2I2U7N8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:FOXS1
gene id: 9685:FOXS1
uniprot id: M3VXH9
names: Subcellular Location Annotation
messages: Nucleus

9685:TRAPPC6B
gene id: 9685:TRAPPC6B
uniprot id: M3WUI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9685:SRSF5
gene id: 9685:SRSF5
uniprot id: M3WAB9
names: Similarity
messages: Belongs to the splicing factor SR family.

9685:NUMB
gene id: 9685:NUMB
uniprot id: A0A2I2UNE8
uniprot id: A0A337STB3
uniprot id: M3X6J0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9685:DDX27
gene id: 9685:DDX27
uniprot id: M3VWN4
names: Similarity
messages: Belongs to the DEAD box helicase family.

9685:ARHGEF6
gene id: 9685:ARHGEF6
uniprot id: M3W1P8
names: Subcellular Location Annotation
messages: lamellipodium

9685:MDH1B
gene id: 9685:MDH1B
uniprot id: A0A5F5XM65
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9685:MGAT5
gene id: 9685:MGAT5
uniprot id: M3WN81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9685:BARHL2
gene id: 9685:BARHL2
uniprot id: M3X0Z3
names: Subcellular Location Annotation
messages: Nucleus

9685:SLC2A1
gene id: 9685:SLC2A1
uniprot id: M3W576
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Membrane
messages: Photoreceptor inner segment

9685:FRRS1
gene id: 9685:FRRS1
uniprot id: M3XEV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9685:THAP1
gene id: 9685:THAP1
uniprot id: A0A2I2V3T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9685:LOC101089514
gene id: 9685:LOC101089514
uniprot id: M3XAW8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:GINS2
gene id: 9685:GINS2
uniprot id: M3W810
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9685:CD4
gene id: 9685:CD4
uniprot id: P79355
names: Subcellular Location Annotation
messages: Cell membrane

9685:ALOX12B
gene id: 9685:ALOX12B
uniprot id: M3WM43
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:OTC
gene id: 9685:OTC
uniprot id: M3WE39
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9685:SLC10A3
gene id: 9685:SLC10A3
uniprot id: A0A5F5XRT6
uniprot id: M3XEG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9685:SLC25A15
gene id: 9685:SLC25A15
uniprot id: M3WT65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:CARMIL3
gene id: 9685:CARMIL3
uniprot id: A0A337S417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9685:PPP1R16A
gene id: 9685:PPP1R16A
uniprot id: M3WKM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:CASP4
gene id: 9685:CASP4
uniprot id: Q9MZV6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cell membrane
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NLRP2 and whose function would be the activation of pro-inflammatory caspases. Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis). Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17P/INCA and CARD18. Interacts with SERPINB1; this interaction regulates CASP1 activity.
messages: The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
messages: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.
messages: Ubiquitinated via 'Lys-11'-linked polyubiquitination. Deubiquitinated by USP8.

9685:AARS1
gene id: 9685:AARS1
uniprot id: M3XF55
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9685:TPM4
gene id: 9685:TPM4
uniprot id: M3WAL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9685:TTC21B
gene id: 9685:TTC21B
uniprot id: M3W8I9
names: Similarity
messages: Belongs to the TTC21 family.

9685:LUM
gene id: 9685:LUM
uniprot id: M3W0X1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

9685:FOXJ1
gene id: 9685:FOXJ1
uniprot id: M3W4P0
names: Subcellular Location Annotation
messages: Nucleus

9685:PCLAF
gene id: 9685:PCLAF
uniprot id: M3X1C5
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

9685:SNX10
gene id: 9685:SNX10
uniprot id: A0A337SJJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9685:THPO
gene id: 9685:THPO
uniprot id: C6EMY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9685:PDX1
gene id: 9685:PDX1
uniprot id: A0A2I2UBZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9685:ASPA
gene id: 9685:ASPA
uniprot id: M3X3I5
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9685:CASC3
gene id: 9685:CASC3
uniprot id: M3WLR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

9685:MIEF1
gene id: 9685:MIEF1
uniprot id: M3WU06
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9685:RARB
gene id: 9685:RARB
uniprot id: M3WD77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9685:SLC12A9
gene id: 9685:SLC12A9
uniprot id: M3W6L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9685:TMEM251
gene id: 9685:TMEM251
uniprot id: M3X151
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM251 family.
messages: Membrane

9685:KCNAB2
gene id: 9685:KCNAB2
uniprot id: A0A337SHY7
uniprot id: A0A337SQG1
uniprot id: M3W5P3
uniprot id: M3X635
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: axon
messages: cytoskeleton
messages: synaptosome

9685:DPEP3
gene id: 9685:DPEP3
uniprot id: A0A5F5XE00
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101095517
gene id: 9685:LOC101095517
uniprot id: M3WPW3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:WDR18
gene id: 9685:WDR18
uniprot id: A0A5F5XRD8
uniprot id: M3W7H8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development.
messages: nucleolus
messages: nucleoplasm

9685:TCTN1
gene id: 9685:TCTN1
uniprot id: M3WEL3
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9685:GTF2A1L
gene id: 9685:GTF2A1L
uniprot id: M3X196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9685:GABPA
gene id: 9685:GABPA
uniprot id: M3WWT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:NFXL1
gene id: 9685:NFXL1
uniprot id: M3WQV3
names: Similarity
messages: Belongs to the NFX1 family.

9685:FOXA2
gene id: 9685:FOXA2
uniprot id: M3WGT1
names: Subcellular Location Annotation
messages: Nucleus

9685:LTN1
gene id: 9685:LTN1
uniprot id: M3WJC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

9685:PDK4
gene id: 9685:PDK4
uniprot id: M3WTN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9685:EED
gene id: 9685:EED
uniprot id: M3VWX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

9685:SOSTDC1
gene id: 9685:SOSTDC1
uniprot id: A0A2I2V496
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:SLC25A14
gene id: 9685:SLC25A14
uniprot id: A0A2I2UPM0
uniprot id: M3W9M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:ZNF768
gene id: 9685:ZNF768
uniprot id: M3WC53
names: Subcellular Location Annotation
messages: Nucleus

9685:DDX11
gene id: 9685:DDX11
uniprot id: A0A5F5XNZ2
uniprot id: M3WNC5
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.

9685:CACNG6
gene id: 9685:CACNG6
uniprot id: A0A337SLV0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

9685:ZDHHC16
gene id: 9685:ZDHHC16
uniprot id: A0A2I2UYH9
uniprot id: M3WIU3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:AHCY
gene id: 9685:AHCY
uniprot id: A0A2I2U551
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9685:PAPSS1
gene id: 9685:PAPSS1
uniprot id: A0A2I2U875
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9685:TCP1
gene id: 9685:TCP1
uniprot id: M3VZ89
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9685:PCNA
gene id: 9685:PCNA
uniprot id: M3WAR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9685:FAM72A
gene id: 9685:FAM72A
uniprot id: A0A2I2UAK6
uniprot id: A0A337SFG5
names: Similarity
messages: Belongs to the FAM72 family.

9685:RPN2
gene id: 9685:RPN2
uniprot id: A0A2I2UR06
uniprot id: A0A337SS26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9685:DAG1
gene id: 9685:DAG1
uniprot id: B4XEM8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9685:GRIA1
gene id: 9685:GRIA1
uniprot id: A0A2I2USC9
uniprot id: M3W3P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9685:RFTN2
gene id: 9685:RFTN2
uniprot id: M3X6L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9685:CRLS1
gene id: 9685:CRLS1
uniprot id: M3WV79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9685:ATP5F1B
gene id: 9685:ATP5F1B
uniprot id: M3WG78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9685:LOC105261264
gene id: 9685:LOC105261264
uniprot id: M3WHR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9685:SIRT5
gene id: 9685:SIRT5
uniprot id: M3XGD7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

9685:DDIT4
gene id: 9685:DDIT4
uniprot id: M3WWJ2
names: Similarity
messages: Belongs to the DDIT4 family.

9685:IDH3B
gene id: 9685:IDH3B
uniprot id: A0A5F5XFX5
uniprot id: M3WKR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9685:CHRNB4
gene id: 9685:CHRNB4
uniprot id: M3VXK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:THBS4
gene id: 9685:THBS4
uniprot id: M3W148
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:GNL2
gene id: 9685:GNL2
uniprot id: M3WA66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9685:NDUFB9
gene id: 9685:NDUFB9
uniprot id: A0A337SB28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9685:CLVS1
gene id: 9685:CLVS1
uniprot id: M3WDA1
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9685:SDR16C5
gene id: 9685:SDR16C5
uniprot id: A0A5F5XXP7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:PROX1
gene id: 9685:PROX1
uniprot id: M3WRD3
names: Subcellular Location Annotation
messages: Nucleus

9685:XKRX
gene id: 9685:XKRX
uniprot id: M3W6W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9685:MPO
gene id: 9685:MPO
uniprot id: B1PSN8
names: Cofactor
messages: Binds 1 Ca(2+) ion per monomer.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.

9685:FOXN3
gene id: 9685:FOXN3
uniprot id: M3WHW5
names: Subcellular Location Annotation
messages: Nucleus

9685:LPL
gene id: 9685:LPL
uniprot id: P55031
names: Activity Regulation
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Defects in LPL are a cause of chylomicronemia syndrome, also known as type I hyperlipoproteinemia. Animals exhibit reduced body mass, growth rates, and increased stillbirth rates.
messages: Homodimer. Interacts with GPIHBP1 with 1:1 stoichiometry (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interaction with heparan sulfate proteoglycans is required to protect LPL against loss of activity. Associates with lipoprotein particles in blood plasma. Interacts with LMF1 and SEL1L; interaction with SEL1L is required to prevent aggregation of newly synthesized LPL in the endoplasmic reticulum (ER), and for normal export of LPL from the ER to the extracellular space (By similarity). Interacts with SORL1; SORL1 acts as a sorting receptor, promoting LPL localization to endosomes and later to lysosomes, leading to degradation of newly synthesized LPL (By similarity).
messages: Key enzyme in triglyceride metabolism (By similarity). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:8636438). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity).
messages: Secreted
messages: The apolipoprotein APOC2 acts as a coactivator of LPL activity (By similarity). Ca(2+) binding promotes protein stability and formation of the active homodimer. Interaction with GPIHBP1 protects LPL against inactivation by ANGPTL4 (By similarity).
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9685:LOC101089545
gene id: 9685:LOC101089545
uniprot id: M3XA86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:FAM124B
gene id: 9685:FAM124B
uniprot id: A0A337RZG3
names: Similarity
messages: Belongs to the FAM124 family.

9685:TRAF2
gene id: 9685:TRAF2
uniprot id: M3VUN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9685:PIR
gene id: 9685:PIR
uniprot id: M3WDC7
names: Similarity
messages: Belongs to the pirin family.

9685:RAPSN
gene id: 9685:RAPSN
uniprot id: M3VYP7
names: Similarity
messages: Belongs to the RAPsyn family.

9685:SS18L2
gene id: 9685:SS18L2
uniprot id: M3VZU8
names: Similarity
messages: Belongs to the SS18 family.

9685:EWSR1
gene id: 9685:EWSR1
uniprot id: A0A337ST85
uniprot id: A0A337STI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9685:LOC101082677
gene id: 9685:LOC101082677
uniprot id: M3X918
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9685:SORD
gene id: 9685:SORD
uniprot id: A0A2I2V1M2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 1 or 2 Zn(2+) ions per subunit.
messages: Homotetramer.
messages: Mitochondrion membrane
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
messages: flagellum

9685:RPS7
gene id: 9685:RPS7
uniprot id: Q5RT64
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Binds IPO9 with high affinity (By similarity). Interacts with NEK6 (By similarity). Interacts with DESI2 (By similarity). Interacts with IPO5, IPO7 and KPNB1; these interactions may be involved in RPS7 nuclear import for the assembly of ribosomal subunits (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by NEK6.
messages: Required for rRNA maturation.
messages: centrosome

9685:LOC100302540
gene id: 9685:LOC100302540
uniprot id: C5NM73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:SSBP2
gene id: 9685:SSBP2
uniprot id: A0A337STZ1
uniprot id: M3WFV6
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101090391
gene id: 9685:LOC101090391
uniprot id: M3X3G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MRPL18
gene id: 9685:MRPL18
uniprot id: M3VZ90
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9685:LEPROT
gene id: 9685:LEPROT
uniprot id: A0A337SDW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9685:TMEM138
gene id: 9685:TMEM138
uniprot id: M3XF15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9685:SGK1
gene id: 9685:SGK1
uniprot id: A0A2I2UTB1
uniprot id: A0A2I2V2C0
uniprot id: A0A337S1I1
uniprot id: A0A337SGE8
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9685:KIF18A
gene id: 9685:KIF18A
uniprot id: M3XGD9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:GPN1
gene id: 9685:GPN1
uniprot id: M3WVZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

9685:AXIN2
gene id: 9685:AXIN2
uniprot id: M3XAL0
names: Subcellular Location Annotation
messages: Cytoplasm

9685:ESYT1
gene id: 9685:ESYT1
uniprot id: M3WLH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:SEMA3E
gene id: 9685:SEMA3E
uniprot id: M3WSU4
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LOC101098401
gene id: 9685:LOC101098401
uniprot id: A0A5F5XHY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GNB2
gene id: 9685:GNB2
uniprot id: M3X5T9
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9685:HEATR5A
gene id: 9685:HEATR5A
uniprot id: A0A337SQL6
uniprot id: M3WLA0
names: Similarity
messages: Belongs to the HEATR5 family.

9685:MTAP
gene id: 9685:MTAP
uniprot id: A0A2I2UPB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9685:LOC101080399
gene id: 9685:LOC101080399
uniprot id: A0A2I2UCA7
names: Similarity
messages: Belongs to the multicopper oxidase family.

9685:CCDC103
gene id: 9685:CCDC103
uniprot id: M3WPN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9685:ICOS
gene id: 9685:ICOS
uniprot id: A0A2I2ULM3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9685:CAND1
gene id: 9685:CAND1
uniprot id: M3X6G0
names: Similarity
messages: Belongs to the CAND family.

9685:CENPO
gene id: 9685:CENPO
uniprot id: M3X8I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9685:DDT
gene id: 9685:DDT
uniprot id: M3WBD6
names: Similarity
messages: Belongs to the MIF family.

9685:FAM126B
gene id: 9685:FAM126B
uniprot id: M3WNF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9685:LOC105260540
gene id: 9685:LOC105260540
uniprot id: M3X726
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:LOC101099406
gene id: 9685:LOC101099406
uniprot id: M3WWR4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:GCK
gene id: 9685:GCK
uniprot id: A3EYB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9685:SLC44A3
gene id: 9685:SLC44A3
uniprot id: A0A2I2U953
uniprot id: M3WLX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9685:ZSCAN9
gene id: 9685:ZSCAN9
uniprot id: A0A2I2UHS9
names: Subcellular Location Annotation
messages: Nucleus

9685:BMP5
gene id: 9685:BMP5
uniprot id: M3W2A2
names: Similarity
messages: Belongs to the TGF-beta family.

9685:GPRC5D
gene id: 9685:GPRC5D
uniprot id: A0A337RVG2
uniprot id: M3WJV8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:DVL1
gene id: 9685:DVL1
uniprot id: M3W823
names: Similarity
messages: Belongs to the DSH family.

9685:NDRG1
gene id: 9685:NDRG1
uniprot id: M3VZX9
names: Similarity
messages: Belongs to the NDRG family.

9685:GABARAP
gene id: 9685:GABARAP
uniprot id: M3X7G0
names: Similarity
messages: Belongs to the ATG8 family.

9685:OTOP3
gene id: 9685:OTOP3
uniprot id: M3VVS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9685:PSMC1
gene id: 9685:PSMC1
uniprot id: A0A2I2UUT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9685:LOC101084990
gene id: 9685:LOC101084990
uniprot id: M3X1U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TCN1
gene id: 9685:TCN1
uniprot id: M3W7W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9685:SESN2
gene id: 9685:SESN2
uniprot id: M3WIS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9685:RPL7A
gene id: 9685:RPL7A
uniprot id: A0A2I2U4W2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

9685:ELL
gene id: 9685:ELL
uniprot id: M3WC08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9685:EIPR1
gene id: 9685:EIPR1
uniprot id: M3WAK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

9685:GRID2
gene id: 9685:GRID2
uniprot id: A0A337SF47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9685:B4GALT6
gene id: 9685:B4GALT6
uniprot id: M3WPN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9685:TRMT13
gene id: 9685:TRMT13
uniprot id: M3X3A4
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9685:RNASE13
gene id: 9685:RNASE13
uniprot id: M3X3R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9685:ADRA2A
gene id: 9685:ADRA2A
uniprot id: Q27RP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:SMIM5
gene id: 9685:SMIM5
uniprot id: M3X8J7
names: Subcellular Location Annotation
messages: Membrane

9685:VKORC1
gene id: 9685:VKORC1
uniprot id: M3WW90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:SLC20A1
gene id: 9685:SLC20A1
uniprot id: O97596
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Ectopic expression of feline SLC20A1 in guinea pig cells which are not permissive to Feline leukemia virus subgroup B (FeLV-B) confers susceptibility to FeLV-B infection.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification.

9685:ARPC2
gene id: 9685:ARPC2
uniprot id: M3VYD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9685:GCM1
gene id: 9685:GCM1
uniprot id: A0A2I2UV51
names: Subcellular Location Annotation
messages: Nucleus

9685:ALDH1B1
gene id: 9685:ALDH1B1
uniprot id: A0A2I2V4J8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9685:OSBPL6
gene id: 9685:OSBPL6
uniprot id: A0A2I2U6Z4
names: Similarity
messages: Belongs to the OSBP family.

9685:ELP6
gene id: 9685:ELP6
uniprot id: A0A2I2UBH8
names: Similarity
messages: Belongs to the ELP6 family.

9685:VWC2L
gene id: 9685:VWC2L
uniprot id: A0A337S692
names: Subcellular Location Annotation
messages: Synapse

9685:LOC101090518
gene id: 9685:LOC101090518
uniprot id: M3WBX2
names: Similarity
messages: Belongs to the MHC class II family.

9685:COG7
gene id: 9685:COG7
uniprot id: M3W3L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:IRAK2
gene id: 9685:IRAK2
uniprot id: M3WEQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9685:SLC22A1
gene id: 9685:SLC22A1
uniprot id: A0A337SUE7
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9685:PIK3CB
gene id: 9685:PIK3CB
uniprot id: M3VZ77
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9685:GRHL2
gene id: 9685:GRHL2
uniprot id: M3W372
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101080702
gene id: 9685:LOC101080702
uniprot id: M3X874
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:BRINP1
gene id: 9685:BRINP1
uniprot id: A0A2I2V4R9
names: Similarity
messages: Belongs to the BRINP family.

9685:STAMBP
gene id: 9685:STAMBP
uniprot id: M3WGC0
names: Similarity
messages: Belongs to the peptidase M67C family.

9685:LOC100302541
gene id: 9685:LOC100302541
uniprot id: C5NM74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:APOC4
gene id: 9685:APOC4
uniprot id: M3W2V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

9685:LOC101089133
gene id: 9685:LOC101089133
uniprot id: A0A5F5Y3P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GABRR1
gene id: 9685:GABRR1
uniprot id: M3XEV9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:ADAMTS9
gene id: 9685:ADAMTS9
uniprot id: A0A337S637
uniprot id: M3VWV5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9685:ESRRG
gene id: 9685:ESRRG
uniprot id: M3XCZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9685:FGF19
gene id: 9685:FGF19
uniprot id: A0A2I2V549
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9685:SST
gene id: 9685:SST
uniprot id: M3W6D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9685:CA5A
gene id: 9685:CA5A
uniprot id: A0A337S4J0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9685:GRB7
gene id: 9685:GRB7
uniprot id: M3WCC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9685:RRAGB
gene id: 9685:RRAGB
uniprot id: M3WJR9
uniprot id: M3X5P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9685:MFSD5
gene id: 9685:MFSD5
uniprot id: M3W4V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

9685:CHRNG
gene id: 9685:CHRNG
uniprot id: A0A2I2UZR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:TPP1
gene id: 9685:TPP1
uniprot id: A0A2I2V5I2
names: Cofactor
messages: Binds 1 Ca(2+) ion per subunit.

9685:NPC1L1
gene id: 9685:NPC1L1
uniprot id: A0A2I2U310
uniprot id: M3WCY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9685:TGIF1
gene id: 9685:TGIF1
uniprot id: M3X9E9
names: Subcellular Location Annotation
messages: Nucleus

9685:RPLP2
gene id: 9685:RPLP2
uniprot id: M3W9K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9685:CACNG7
gene id: 9685:CACNG7
uniprot id: M3VWV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

9685:RABGGTB
gene id: 9685:RABGGTB
uniprot id: A0A2I2UUA5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9685:ELOVL4
gene id: 9685:ELOVL4
uniprot id: A0A2I2U7Q6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9685:UNK
gene id: 9685:UNK
uniprot id: A0A5F5XPP6
uniprot id: M3W4M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9685:PGC
gene id: 9685:PGC
uniprot id: M3WL88
names: Function
names: Similarity
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.

9685:LOC101100002
gene id: 9685:LOC101100002
uniprot id: M3WRY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PRDX6
gene id: 9685:PRDX6
uniprot id: A0A2I2UL25
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9685:GABRB2
gene id: 9685:GABRB2
uniprot id: A0A341ZMF7
uniprot id: M3VVX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:CAPZA3
gene id: 9685:CAPZA3
uniprot id: M3W7D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9685:LOC101099146
gene id: 9685:LOC101099146
uniprot id: A0A5F5XRA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TAS1R3
gene id: 9685:TAS1R3
uniprot id: Q49KI5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
messages: Cell membrane
messages: Expressed in taste buds.
messages: Forms homodimers or a heterodimer with TAS1R1.
messages: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) (By similarity).
messages: Unlike most mammals domestic cats do not prefer and are unable to detect the sweetness of sugars. This is due to pseudogenization of the TAS1R2 gene which prevents the formation of the heterodimeric sweet taste receptor TAS1R2/TAS1R3. This molecular change was very likely an important event in the evolution of the cat's carnivorous behavior.

9685:LOC101089637
gene id: 9685:LOC101089637
uniprot id: M3WYZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CCL1
gene id: 9685:CCL1
uniprot id: A0A2I2UC63
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9685:YWHAZ
gene id: 9685:YWHAZ
uniprot id: M3WVC7
names: Similarity
messages: Belongs to the 14-3-3 family.

9685:GALR1
gene id: 9685:GALR1
uniprot id: M3WA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9685:EHD3
gene id: 9685:EHD3
uniprot id: M3X2J9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9685:EXOC2
gene id: 9685:EXOC2
uniprot id: A0A2I2UJ50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9685:GLRX
gene id: 9685:GLRX
uniprot id: M3X3M9
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9685:TAF11
gene id: 9685:TAF11
uniprot id: A0A2I2URS1
uniprot id: M3WTA9
names: Similarity
messages: Belongs to the TAF11 family.

9685:RC3H2
gene id: 9685:RC3H2
uniprot id: A0A337S8A1
names: Subcellular Location Annotation
messages: P-body

9685:KCTD13
gene id: 9685:KCTD13
uniprot id: M3XGC5
names: Similarity
messages: Belongs to the BACURD family.

9685:CSAD
gene id: 9685:CSAD
uniprot id: A0A5F5XGY6
names: Similarity
messages: Belongs to the group II decarboxylase family.

9685:SERPINA12
gene id: 9685:SERPINA12
uniprot id: A0A2I2UZ95
names: Similarity
messages: Belongs to the serpin family.

9685:GPX6
gene id: 9685:GPX6
uniprot id: A0A5F5XKJ5
uniprot id: M3W083
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9685:KIF5B
gene id: 9685:KIF5B
uniprot id: M3WU61
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:GALNT15
gene id: 9685:GALNT15
uniprot id: M3W5R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9685:BLOC1S6
gene id: 9685:BLOC1S6
uniprot id: A0A337S6D6
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9685:RNF121
gene id: 9685:RNF121
uniprot id: M3W3V2
names: Subcellular Location Annotation
messages: Membrane

9685:CLK3
gene id: 9685:CLK3
uniprot id: A0A2I2UMG1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:AKT2
gene id: 9685:AKT2
uniprot id: M3WGH1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9685:IFNE
gene id: 9685:IFNE
uniprot id: I3UJJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9685:GABRG2
gene id: 9685:GABRG2
uniprot id: A0A2I2U2A5
uniprot id: A0A2I2UNR3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:ENPP2
gene id: 9685:ENPP2
uniprot id: A0A2I2V3L7
uniprot id: A0A5F5XFW6
uniprot id: M3WE79
uniprot id: M3XD38
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

9685:STAT6
gene id: 9685:STAT6
uniprot id: M3WKY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9685:LOC101091533
gene id: 9685:LOC101091533
uniprot id: A0A5F5XI95
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:FKBP5
gene id: 9685:FKBP5
uniprot id: M3X0R0
names: Subcellular Location Annotation
messages: Nucleus

9685:CTBP2
gene id: 9685:CTBP2
uniprot id: M3VYH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9685:RBM10
gene id: 9685:RBM10
uniprot id: M3VWK2
names: Subcellular Location Annotation
messages: Nucleus

9685:TYW3
gene id: 9685:TYW3
uniprot id: A0A2I2U834
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9685:LOC101096691
gene id: 9685:LOC101096691
uniprot id: M3X2L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PHACTR1
gene id: 9685:PHACTR1
uniprot id: M3WKW8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

9685:FMR1
gene id: 9685:FMR1
uniprot id: A0A2I2V070
uniprot id: A0A5F5XJT1
uniprot id: M3W7C6
uniprot id: M3WUC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9685:TACR1
gene id: 9685:TACR1
uniprot id: M3W532
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9685:INTS13
gene id: 9685:INTS13
uniprot id: M3W203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

9685:POLR2G
gene id: 9685:POLR2G
uniprot id: M3X707
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

9685:GDF10
gene id: 9685:GDF10
uniprot id: A0A5F5Y1W4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9685:HMOX2
gene id: 9685:HMOX2
uniprot id: M3WGV3
names: Similarity
messages: Belongs to the heme oxygenase family.

9685:PON1
gene id: 9685:PON1
uniprot id: A0A2I2UU74
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9685:ACOX3
gene id: 9685:ACOX3
uniprot id: M3WMB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9685:NOL10
gene id: 9685:NOL10
uniprot id: M3WB31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9685:RNF2
gene id: 9685:RNF2
uniprot id: A0A337S6P8
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

9685:FN3K
gene id: 9685:FN3K
uniprot id: M3WJX9
names: Similarity
messages: Belongs to the fructosamine kinase family.

9685:DDX49
gene id: 9685:DDX49
uniprot id: M3WC25
names: Similarity
messages: Belongs to the DEAD box helicase family.

9685:H2AJ
gene id: 9685:H2AJ
uniprot id: M3X2B2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:GSTK1
gene id: 9685:GSTK1
uniprot id: M3W7F3
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9685:N4BP3
gene id: 9685:N4BP3
uniprot id: M3X8L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Vesicle
messages: axon
messages: dendrite

9685:BTD
gene id: 9685:BTD
uniprot id: M3WEV4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9685:ACAT2
gene id: 9685:ACAT2
uniprot id: M3VZ88
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9685:TRARG1
gene id: 9685:TRARG1
uniprot id: A0A2I2URY2
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9685:LOC101081808
gene id: 9685:LOC101081808
uniprot id: A0A5F5XZ66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9685:IL2
gene id: 9685:IL2
uniprot id: Q07885
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9685:ZDHHC3
gene id: 9685:ZDHHC3
uniprot id: A0A2I2UTX1
uniprot id: A0A5F5XK40
uniprot id: M3W836
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:ST6GAL1
gene id: 9685:ST6GAL1
uniprot id: M3WJN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9685:LOC101093577
gene id: 9685:LOC101093577
uniprot id: M3X4M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PSMD7
gene id: 9685:PSMD7
uniprot id: M3WTN9
names: Similarity
messages: Belongs to the peptidase M67A family.

9685:EML6
gene id: 9685:EML6
uniprot id: M3WNG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
messages: cytoskeleton

9685:COPS5
gene id: 9685:COPS5
uniprot id: A0A5F5XZQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9685:ADAM8
gene id: 9685:ADAM8
uniprot id: A0A2I2V2H3
uniprot id: M3WPQ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LRRC14
gene id: 9685:LRRC14
uniprot id: M3WKM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRAME family. LRRC14 subfamily.
messages: Cytoplasm

9685:BNIP3L
gene id: 9685:BNIP3L
uniprot id: M3XF65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9685:ACOX1
gene id: 9685:ACOX1
uniprot id: A0A5F5Y851
uniprot id: M3W4N4
uniprot id: M3WR09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9685:FBLN2
gene id: 9685:FBLN2
uniprot id: A0A2I2UFJ4
uniprot id: M3W7U0
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:ATP1B1
gene id: 9685:ATP1B1
uniprot id: M3WB86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
messages: sarcolemma

9685:SSX2IP
gene id: 9685:SSX2IP
uniprot id: M3WQ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

9685:CLCN1
gene id: 9685:CLCN1
uniprot id: A0A059WLP9
names: Subcellular Location Annotation
messages: Membrane

9685:RABEP2
gene id: 9685:RABEP2
uniprot id: A0A337SCI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Early endosome
messages: Endosome
messages: centrosome
messages: cilium basal body

9685:RGS4
gene id: 9685:RGS4
uniprot id: M3X000
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9685:RPL27
gene id: 9685:RPL27
uniprot id: M3WIA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9685:RPLP0
gene id: 9685:RPLP0
uniprot id: M3WIQ1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9685:MMP20
gene id: 9685:MMP20
uniprot id: M3WN98
names: Similarity
messages: Belongs to the peptidase M10A family.

9685:DTX2
gene id: 9685:DTX2
uniprot id: A0A2I2UZU2
uniprot id: M3WIX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9685:NHP2
gene id: 9685:NHP2
uniprot id: A0A5F5XS68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9685:LOC101090464
gene id: 9685:LOC101090464
uniprot id: M3WTD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PPP2R5C
gene id: 9685:PPP2R5C
uniprot id: A0A337S4F6
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9685:AMIGO2
gene id: 9685:AMIGO2
uniprot id: M3VWT3
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9685:DTD2
gene id: 9685:DTD2
uniprot id: M3X539
names: Similarity
messages: Belongs to the DTD family.

9685:LOC101087522
gene id: 9685:LOC101087522
uniprot id: M3X7I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:FLNB
gene id: 9685:FLNB
uniprot id: A0A2I2US09
uniprot id: A0A2I2UUW4
uniprot id: M3W620
names: Similarity
messages: Belongs to the filamin family.

9685:ART3
gene id: 9685:ART3
uniprot id: A0A5F5Y767
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9685:YIPF3
gene id: 9685:YIPF3
uniprot id: M3WC02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

9685:DPP4
gene id: 9685:DPP4
uniprot id: Q9N2I7
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
messages: Inhibited by GPC3 and diprotin A.
messages: Membrane raft
messages: Monomer. Homodimer. Heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes. Interacts (extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3.
messages: N- and O-Glycosylated.
messages: Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation (By similarity).
messages: Secreted
messages: The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
messages: invadopodium membrane
messages: lamellipodium membrane

9685:AQR
gene id: 9685:AQR
uniprot id: M3WK08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWF11 family.
messages: Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.
messages: Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
messages: Nucleus

9685:HMGB2
gene id: 9685:HMGB2
uniprot id: M3W1S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9685:MTHFR
gene id: 9685:MTHFR
uniprot id: M3VU14
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

9685:LOC101096974
gene id: 9685:LOC101096974
uniprot id: M3WVQ9
names: Similarity
messages: Belongs to the TTC39 family.

9685:PSMB9
gene id: 9685:PSMB9
uniprot id: M3X308
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9685:ELOVL2
gene id: 9685:ELOVL2
uniprot id: A0A5F5Y4H9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9685:JUNB
gene id: 9685:JUNB
uniprot id: M3WS52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9685:EXTL2
gene id: 9685:EXTL2
uniprot id: A0A337S6P4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:MAD1L1
gene id: 9685:MAD1L1
uniprot id: A0A5F5Y2P6
names: Similarity
messages: Belongs to the MAD1 family.

9685:CHPT1
gene id: 9685:CHPT1
uniprot id: M3XC97
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9685:MYOF
gene id: 9685:MYOF
uniprot id: A0A2I2UE28
uniprot id: A0A2I2UXC0
uniprot id: A0A2I2UYS8
uniprot id: M3WCE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9685:GOLM2
gene id: 9685:GOLM2
uniprot id: A0A2I2UII2
uniprot id: M3WMY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9685:APLN
gene id: 9685:APLN
uniprot id: A0A337S4B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apelin family.
messages: extracellular space

9685:SPIB
gene id: 9685:SPIB
uniprot id: A0A2I2UH83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:LOC101098177
gene id: 9685:LOC101098177
uniprot id: M3XEY2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TMC3
gene id: 9685:TMC3
uniprot id: M3WJT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9685:GSTO2
gene id: 9685:GSTO2
uniprot id: A0A337S1D7
uniprot id: M3W556
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9685:CDK2
gene id: 9685:CDK2
uniprot id: A0A2I2UCH2
uniprot id: A0A2I2UFY5
uniprot id: A0A2I2V4K7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:EIF1AX
gene id: 9685:EIF1AX
uniprot id: A0A337S322
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

9685:SGCG
gene id: 9685:SGCG
uniprot id: A0A2I2U0C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

9685:ST6GALNAC3
gene id: 9685:ST6GALNAC3
uniprot id: M3WK21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9685:CDC20
gene id: 9685:CDC20
uniprot id: A0A2I2UJ86
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9685:CLDN5
gene id: 9685:CLDN5
uniprot id: M3WYM1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:PLCD4
gene id: 9685:PLCD4
uniprot id: A0A2I2U6E8
uniprot id: M3W1N6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
messages: Nucleus

9685:CALHM2
gene id: 9685:CALHM2
uniprot id: M3VYF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9685:PFKFB4
gene id: 9685:PFKFB4
uniprot id: A0A5F5XDE7
uniprot id: A0A5F5XJL2
uniprot id: A0A5F5Y461
uniprot id: M3VXW4
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9685:FOLH1B
gene id: 9685:FOLH1B
uniprot id: A0A337SB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9685:VAC14
gene id: 9685:VAC14
uniprot id: M3W3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9685:TNFSF14
gene id: 9685:TNFSF14
uniprot id: A0A2I2U2B1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9685:PDIA3
gene id: 9685:PDIA3
uniprot id: M3W668
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9685:BCAR1
gene id: 9685:BCAR1
uniprot id: M3WMG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9685:BMP3
gene id: 9685:BMP3
uniprot id: M3W8F5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9685:RCAN2
gene id: 9685:RCAN2
uniprot id: A0A337RYV5
uniprot id: A0A337SIU8
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9685:HOXB7
gene id: 9685:HOXB7
uniprot id: M3VXX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9685:VPS4B
gene id: 9685:VPS4B
uniprot id: M3WXF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9685:FLVCR1
gene id: 9685:FLVCR1
uniprot id: Q9N1F2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
messages: Cell membrane
messages: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies (By similarity). Confers susceptibility to Feline leukemia virus subgroup C (FeLV-C) infection, which is associated with fatal erythroid aplasia, also known as aplastic anemia (PubMed:10648427).
messages: Interacts with HPX.
messages: N-Glycosylated.

9685:LOC101094538
gene id: 9685:LOC101094538
uniprot id: M3X079
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GPHB5
gene id: 9685:GPHB5
uniprot id: M3XD03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9685:LOC101099075
gene id: 9685:LOC101099075
uniprot id: Q1T770
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9685:NELL1
gene id: 9685:NELL1
uniprot id: A0A337RXS0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:SRPRA
gene id: 9685:SRPRA
uniprot id: A0A2I2UWH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

9685:SMYHC
gene id: 9685:SMYHC
uniprot id: A0A5F5XV97
uniprot id: O97757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9685:IER2
gene id: 9685:IER2
uniprot id: M3VUV2
names: Similarity
messages: Belongs to the IER family.

9685:LOC101097653
gene id: 9685:LOC101097653
uniprot id: A0A337S9C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TMEM234
gene id: 9685:TMEM234
uniprot id: M3XA96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

9685:IFNB1
gene id: 9685:IFNB1
uniprot id: A1YQW1
uniprot id: Q9N2J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family.
messages: Monomer.
messages: Secreted
messages: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).

9685:LOC105260538
gene id: 9685:LOC105260538
uniprot id: M3WSM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:RARS2
gene id: 9685:RARS2
uniprot id: A0A2I2U7G2
uniprot id: A0A5F5XV42
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9685:INA
gene id: 9685:INA
uniprot id: M3WWQ5
names: Similarity
messages: Belongs to the intermediate filament family.

9685:SLC24A4
gene id: 9685:SLC24A4
uniprot id: M3W8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9685:ODF1
gene id: 9685:ODF1
uniprot id: M3W6P2
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9685:IDH3G
gene id: 9685:IDH3G
uniprot id: A0A2I2V4K1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9685:CYSLTR1
gene id: 9685:CYSLTR1
uniprot id: M3X6V9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:TMC7
gene id: 9685:TMC7
uniprot id: M3X9J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9685:EXOG
gene id: 9685:EXOG
uniprot id: M3VZU1
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9685:ITGA7
gene id: 9685:ITGA7
uniprot id: A0A2I2U4E5
uniprot id: M3WJT5
uniprot id: M3X2Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9685:FAM76A
gene id: 9685:FAM76A
uniprot id: A0A2I2UMN0
names: Similarity
messages: Belongs to the FAM76 family.

9685:CDS1
gene id: 9685:CDS1
uniprot id: M3XA08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9685:BCR
gene id: 9685:BCR
uniprot id: M3WRN9
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9685:LETM1
gene id: 9685:LETM1
uniprot id: A0A5F5Y4I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

9685:ADSS2
gene id: 9685:ADSS2
uniprot id: A0A2I2URN8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

9685:SLC35F4
gene id: 9685:SLC35F4
uniprot id: A0A337SXC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9685:JPT2
gene id: 9685:JPT2
uniprot id: A0A2I2U7H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9685:EIF2A
gene id: 9685:EIF2A
uniprot id: M3WEX5
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9685:CUL5
gene id: 9685:CUL5
uniprot id: G1FQD7
names: Similarity
messages: Belongs to the cullin family.

9685:CD53
gene id: 9685:CD53
uniprot id: M3W8H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:ERGIC2
gene id: 9685:ERGIC2
uniprot id: M3WNL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9685:PPM1N
gene id: 9685:PPM1N
uniprot id: M3XB35
names: Similarity
messages: Belongs to the PP2C family.

9685:KRT33A
gene id: 9685:KRT33A
uniprot id: M3VXJ5
names: Similarity
messages: Belongs to the intermediate filament family.

9685:IFNG
gene id: 9685:IFNG
uniprot id: A9UKW5
uniprot id: P46402
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Released primarily from activated T lymphocytes.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9685:SAMM50
gene id: 9685:SAMM50
uniprot id: M3W7J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9685:SNRPD1
gene id: 9685:SNRPD1
uniprot id: A0A2I2U9H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9685:LOC101087113
gene id: 9685:LOC101087113
uniprot id: M3XCD0
names: Similarity
messages: Belongs to the KRTAP type 3 family.

9685:PTPN6
gene id: 9685:PTPN6
uniprot id: A0A337SE66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9685:SNAPIN
gene id: 9685:SNAPIN
uniprot id: M3W934
names: Similarity
messages: Belongs to the SNAPIN family.

9685:ACTRT3
gene id: 9685:ACTRT3
uniprot id: A0A2I2UVN2
names: Similarity
messages: Belongs to the actin family.

9685:ADGRL4
gene id: 9685:ADGRL4
uniprot id: A0A337SL34
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:AHCYL2
gene id: 9685:AHCYL2
uniprot id: A0A2I2US36
uniprot id: M3XD17
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9685:NXPH4
gene id: 9685:NXPH4
uniprot id: M3X0B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9685:ELOC
gene id: 9685:ELOC
uniprot id: F8V3I9
names: Similarity
messages: Belongs to the SKP1 family.

9685:YAE1
gene id: 9685:YAE1
uniprot id: M3X5T8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9685:SIX1
gene id: 9685:SIX1
uniprot id: M3XF50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

9685:TATDN2
gene id: 9685:TATDN2
uniprot id: M3WEQ7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9685:MMP12
gene id: 9685:MMP12
uniprot id: M3WEA4
names: Similarity
messages: Belongs to the peptidase M10A family.

9685:ARGLU1
gene id: 9685:ARGLU1
uniprot id: A0A2I2U281
names: Similarity
messages: Belongs to the UPF0430 family.

9685:FGFR1
gene id: 9685:FGFR1
uniprot id: H9U391
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9685:ATP2B4
gene id: 9685:ATP2B4
uniprot id: A0A2I2UVB8
uniprot id: A0A2I2V0M6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:H1-4
gene id: 9685:H1-4
uniprot id: A0A5F5XKM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9685:F7
gene id: 9685:F7
uniprot id: M3WKC6
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of a light chain and a heavy chain linked by a disulfide bond.
messages: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:LOC101089767
gene id: 9685:LOC101089767
uniprot id: M3WSM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:PFDN5
gene id: 9685:PFDN5
uniprot id: A0A337S850
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9685:MFAP3
gene id: 9685:MFAP3
uniprot id: M3X646
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:GFAP
gene id: 9685:GFAP
uniprot id: A0A2I2UI95
uniprot id: M3W443
names: Function
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
messages: Interacts with SYNM.

9685:MRPS17
gene id: 9685:MRPS17
uniprot id: A0A337SE92
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9685:URM1
gene id: 9685:URM1
uniprot id: M3W4T2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9685:EHD4
gene id: 9685:EHD4
uniprot id: M3WXE7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9685:SEC23B
gene id: 9685:SEC23B
uniprot id: M3WJJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9685:TBX5
gene id: 9685:TBX5
uniprot id: M3W4A8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:PPP1CB
gene id: 9685:PPP1CB
uniprot id: M3XDH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9685:GRM2
gene id: 9685:GRM2
uniprot id: A0A2I2UA64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9685:GIMAP5
gene id: 9685:GIMAP5
uniprot id: A0A2I2U613
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9685:FGD4
gene id: 9685:FGD4
uniprot id: A0A2I2U4C8
names: Subcellular Location Annotation
messages: cytoskeleton

9685:SEBOX
gene id: 9685:SEBOX
uniprot id: M3W9I4
names: Subcellular Location Annotation
messages: Nucleus

9685:CHAC2
gene id: 9685:CHAC2
uniprot id: M3X427
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9685:SLC39A4
gene id: 9685:SLC39A4
uniprot id: A0A2I2UZD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9685:GDAP2
gene id: 9685:GDAP2
uniprot id: M3W0E2
names: Similarity
messages: Belongs to the GDAP2 family.

9685:RAD17
gene id: 9685:RAD17
uniprot id: A0A5F5XX94
uniprot id: M3VYL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9685:LOC101096427
gene id: 9685:LOC101096427
uniprot id: A0A5F5Y6X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:HGD
gene id: 9685:HGD
uniprot id: M3XF73
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9685:THRAP3
gene id: 9685:THRAP3
uniprot id: A0A2I2UD94
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9685:MME
gene id: 9685:MME
uniprot id: A0A337SXF4
names: Cofactor
messages: Binds 1 zinc ion per subunit.

9685:FAM118A
gene id: 9685:FAM118A
uniprot id: A0A2I2UN00
names: Similarity
messages: Belongs to the FAM118 family.

9685:PGAP1
gene id: 9685:PGAP1
uniprot id: A0A337SUT7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:CARTPT
gene id: 9685:CARTPT
uniprot id: M3VZP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9685:KCNN2
gene id: 9685:KCNN2
uniprot id: M3X7U2
names: Subcellular Location Annotation
messages: Membrane

9685:LOC102899730
gene id: 9685:LOC102899730
uniprot id: A0A5F5XWR1
names: Similarity
messages: Belongs to the GAGE family.

9685:BZW2
gene id: 9685:BZW2
uniprot id: M3WAT8
names: Similarity
messages: Belongs to the BZW family.

9685:NOP16
gene id: 9685:NOP16
uniprot id: M3WSL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9685:PAIP2B
gene id: 9685:PAIP2B
uniprot id: A0A2I2V2S0
names: Similarity
messages: Belongs to the PAIP2 family.

9685:TFAP2C
gene id: 9685:TFAP2C
uniprot id: A0A5F5XG34
names: Similarity
messages: Belongs to the AP-2 family.

9685:AVPI1
gene id: 9685:AVPI1
uniprot id: M3WWB2
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9685:LOC101093328
gene id: 9685:LOC101093328
uniprot id: A0A5F5XHE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MOS
gene id: 9685:MOS
uniprot id: M3W0R3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:MC2R
gene id: 9685:MC2R
uniprot id: M3WZX2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

9685:CA3H20orf27
gene id: 9685:CA3H20orf27
uniprot id: M3X3E2
names: Similarity
messages: Belongs to the UPF0687 family.

9685:BAX
gene id: 9685:BAX
uniprot id: Q8SQ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9685:PIF1
gene id: 9685:PIF1
uniprot id: M3WEX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

9685:FTL
gene id: 9685:FTL
uniprot id: Q2MHN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

9685:CAMP
gene id: 9685:CAMP
uniprot id: F1C962
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9685:DIMT1
gene id: 9685:DIMT1
uniprot id: A0A2I2UQG6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9685:BVES
gene id: 9685:BVES
uniprot id: M3W3E1
names: Similarity
messages: Belongs to the popeye family.

9685:TSN
gene id: 9685:TSN
uniprot id: M3X4R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9685:ADCYAP1R1
gene id: 9685:ADCYAP1R1
uniprot id: A0A2I2UK30
uniprot id: A0A337SH77
uniprot id: A0A337SPS9
names: Subcellular Location Annotation
messages: Membrane

9685:PRICKLE3
gene id: 9685:PRICKLE3
uniprot id: M3WVY2
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9685:LOC101086714
gene id: 9685:LOC101086714
uniprot id: A0A5F5XJZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SART3
gene id: 9685:SART3
uniprot id: A0A337S1C3
names: Subcellular Location Annotation
messages: nucleoplasm

9685:ZIC4
gene id: 9685:ZIC4
uniprot id: A0A2I2U6W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9685:AKAP5
gene id: 9685:AKAP5
uniprot id: M3X394
names: Subcellular Location Annotation
messages: Membrane

9685:ACKR4
gene id: 9685:ACKR4
uniprot id: M3W144
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:SLC7A7
gene id: 9685:SLC7A7
uniprot id: M3X3N4
names: Subcellular Location Annotation
messages: Membrane

9685:TM2D3
gene id: 9685:TM2D3
uniprot id: M3X295
names: Subcellular Location Annotation
messages: Membrane

9685:FAM167B
gene id: 9685:FAM167B
uniprot id: M3WH16
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9685:LOC101085477
gene id: 9685:LOC101085477
uniprot id: M3VW66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RAP2B
gene id: 9685:RAP2B
uniprot id: M3W509
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9685:LOC101081091
gene id: 9685:LOC101081091
uniprot id: A0A2I2V3G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:CCR7
gene id: 9685:CCR7
uniprot id: A0A2I2V2J2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:SLC15A2
gene id: 9685:SLC15A2
uniprot id: M3WA33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9685:VMA21
gene id: 9685:VMA21
uniprot id: A0A2I2V587
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9685:SLC4A7
gene id: 9685:SLC4A7
uniprot id: M3XDR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9685:KEF43 p05
gene id: 9685:KEF43_p05
uniprot id: P48931
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Mitochondrion inner membrane

9685:HOXB1
gene id: 9685:HOXB1
uniprot id: M3X6P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9685:NME9
gene id: 9685:NME9
uniprot id: M3X2W4
names: Similarity
messages: Belongs to the NDK family.

9685:EIF3H
gene id: 9685:EIF3H
uniprot id: M3WLF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9685:MLH1
gene id: 9685:MLH1
uniprot id: M3VWJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9685:L3MBTL3
gene id: 9685:L3MBTL3
uniprot id: A0A337SK85
names: Subcellular Location Annotation
messages: Nucleus

9685:APOA4
gene id: 9685:APOA4
uniprot id: M3W955
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Homodimer.
messages: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
messages: Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
messages: Secreted

9685:RELL2
gene id: 9685:RELL2
uniprot id: M3W6Q3
names: Similarity
messages: Belongs to the RELT family.

9685:TMA16
gene id: 9685:TMA16
uniprot id: M3X5D1
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9685:SELL
gene id: 9685:SELL
uniprot id: A2V6R9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:B4GAT1
gene id: 9685:B4GAT1
uniprot id: M3WQ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:TAF13
gene id: 9685:TAF13
uniprot id: A0A2I2UHN0
names: Subcellular Location Annotation
messages: Nucleus

9685:PPP6R3
gene id: 9685:PPP6R3
uniprot id: A0A2I2UFD3
uniprot id: A0A337SIC0
uniprot id: M3W3F4
uniprot id: M3X6W7
names: Similarity
messages: Belongs to the SAPS family.

9685:NHEJ1
gene id: 9685:NHEJ1
uniprot id: A0A2I2UCH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

9685:CHGB
gene id: 9685:CHGB
uniprot id: M3VUB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9685:DNAJC2
gene id: 9685:DNAJC2
uniprot id: M3VV50
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: cytosol

9685:PSMB5
gene id: 9685:PSMB5
uniprot id: A0A337SNC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9685:SSR3
gene id: 9685:SSR3
uniprot id: M3X2V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9685:TSPAN15
gene id: 9685:TSPAN15
uniprot id: M3W349
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:KCNA6
gene id: 9685:KCNA6
uniprot id: M3VYC4
names: Subcellular Location Annotation
messages: Membrane

9685:PNLDC1
gene id: 9685:PNLDC1
uniprot id: M3VZ91
names: Similarity
messages: Belongs to the CAF1 family.

9685:LOC101096683
gene id: 9685:LOC101096683
uniprot id: M3XFB6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:KCNMB3
gene id: 9685:KCNMB3
uniprot id: A0A337SF69
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9685:POLR2D
gene id: 9685:POLR2D
uniprot id: M3WUR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

9685:ISCU
gene id: 9685:ISCU
uniprot id: A0A2I2USP2
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

9685:SFMBT1
gene id: 9685:SFMBT1
uniprot id: M3W157
names: Subcellular Location Annotation
messages: Nucleus

9685:ACTG2
gene id: 9685:ACTG2
uniprot id: M3WGC1
names: Similarity
messages: Belongs to the actin family.

9685:TGM2
gene id: 9685:TGM2
uniprot id: M3W2W5
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9685:DDIT3
gene id: 9685:DDIT3
uniprot id: M3VXV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9685:DIO1
gene id: 9685:DIO1
uniprot id: Q6V915
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iodothyronine deiodinase family.
messages: Endoplasmic reticulum membrane
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.

9685:ATP6V0B
gene id: 9685:ATP6V0B
uniprot id: M3W601
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9685:LOC101100413
gene id: 9685:LOC101100413
uniprot id: A0A2I2UWX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PIK3C2G
gene id: 9685:PIK3C2G
uniprot id: A0A2I2UQE0
uniprot id: A0A2I2V1L7
uniprot id: A0A337SIH2
uniprot id: M3VUD0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9685:MYOD1
gene id: 9685:MYOD1
uniprot id: M3W380
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9685:CLEC12A
gene id: 9685:CLEC12A
uniprot id: M3X0Z4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:MFSD4B
gene id: 9685:MFSD4B
uniprot id: A0A337SLE2
names: Subcellular Location Annotation
messages: Membrane

9685:HTR2C
gene id: 9685:HTR2C
uniprot id: A0A2I2UEL5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MPDZ. Interacts with ARRB2.
messages: Membrane

9685:EHD1
gene id: 9685:EHD1
uniprot id: M3X1U0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9685:CXXC5
gene id: 9685:CXXC5
uniprot id: M3WDF6
names: Subcellular Location Annotation
messages: Cytoplasm

9685:TSEN54
gene id: 9685:TSEN54
uniprot id: M3XA93
names: Similarity
messages: Belongs to the SEN54 family.

9685:COA5
gene id: 9685:COA5
uniprot id: M3W257
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9685:MRPS33
gene id: 9685:MRPS33
uniprot id: M3X647
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9685:PRPF38A
gene id: 9685:PRPF38A
uniprot id: M3VYN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9685:HMCN1
gene id: 9685:HMCN1
uniprot id: M3X1M2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CSF1R
gene id: 9685:CSF1R
uniprot id: P13369
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-558 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-558 and Tyr-807 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-696 and Tyr-921 is important for interaction with GRB2. Phosphorylation at Tyr-720 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-807 is important for interaction with PLCG2. Phosphorylation at Tyr-977 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Monomer. Homodimer. Interacts with CSF1 and IL34. Interaction with dimeric CSF1 or IL34 leads to receptor homodimerization. Interacts with INPPL1/SHIP2 and THOC5. Interacts (tyrosine phosphorylated) with PLCG2 (via SH2 domain). Interacts (tyrosine phosphorylated) with PIK3R1 (via SH2 domain). Interacts (tyrosine phosphorylated) with FYN, YES1 and SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with CBL, GRB2 and SLA2 (By similarity).
messages: Present in an inactive conformation in the absence of bound ligand. CSF1 or IL34 binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: The activation loop plays an important role in the regulation of kinase activity. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase (By similarity).
messages: The juxtamembrane domain functions as autoinhibitory region. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, th…
messages: Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation (By similarity).

9685:NAGK
gene id: 9685:NAGK
uniprot id: M3WZW7
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9685:CSF3
gene id: 9685:CSF3
uniprot id: Q9GJU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
messages: Secreted

9685:GNAL
gene id: 9685:GNAL
uniprot id: M3XAG1
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9685:PIANP
gene id: 9685:PIANP
uniprot id: M3WYB3
names: Subcellular Location Annotation
messages: Membrane

9685:VCAN
gene id: 9685:VCAN
uniprot id: A0A337S7H7
uniprot id: M3XC11
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9685:CD1H11orf54
gene id: 9685:CD1H11orf54
uniprot id: A0A2I2U7D8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9685:LOC101097186
gene id: 9685:LOC101097186
uniprot id: M3W7S7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RPE
gene id: 9685:RPE
uniprot id: M3WAV5
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9685:GALNT13
gene id: 9685:GALNT13
uniprot id: A0A5F5XHE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9685:NFYA
gene id: 9685:NFYA
uniprot id: A0A2I2U126
uniprot id: M3WUH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9685:SLCO2B1
gene id: 9685:SLCO2B1
uniprot id: M3WG20
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:PIAS1
gene id: 9685:PIAS1
uniprot id: A0A337S3L4
uniprot id: M3WNG9
names: Similarity
messages: Belongs to the PIAS family.

9685:RAD23A
gene id: 9685:RAD23A
uniprot id: M3X1H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9685:TOR2A
gene id: 9685:TOR2A
uniprot id: M3WVJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9685:XPR1
gene id: 9685:XPR1
uniprot id: E2J866
uniprot id: M3WFX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

9685:PTGDR
gene id: 9685:PTGDR
uniprot id: A0A337SA56
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:PIWIL1
gene id: 9685:PIWIL1
uniprot id: M3WKG8
names: Similarity
messages: Belongs to the argonaute family.

9685:LSM7
gene id: 9685:LSM7
uniprot id: M3W0C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9685:FADS1
gene id: 9685:FADS1
uniprot id: M3WJB1
names: Similarity
messages: Belongs to the fatty acid desaturase type 1 family.

9685:ATP8B1
gene id: 9685:ATP8B1
uniprot id: M3WKG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9685:OSGEP
gene id: 9685:OSGEP
uniprot id: M3W6S4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Cytoplasm
messages: Nucleus

9685:STT3A
gene id: 9685:STT3A
uniprot id: M3WLY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9685:PPY
gene id: 9685:PPY
uniprot id: A0A0A0MQ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
messages: Secreted

9685:ADAMTS15
gene id: 9685:ADAMTS15
uniprot id: M3W9E9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9685:EXOC6
gene id: 9685:EXOC6
uniprot id: M3X6I4
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9685:NDUFB7
gene id: 9685:NDUFB7
uniprot id: M3WIY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9685:KCNK2
gene id: 9685:KCNK2
uniprot id: A0A2I2UGN8
uniprot id: M3WVE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9685:CNOT2
gene id: 9685:CNOT2
uniprot id: A0A2I2UXJ2
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9685:CYP27A1
gene id: 9685:CYP27A1
uniprot id: M3W709
names: Similarity
messages: Belongs to the cytochrome P450 family.

9685:ATP5MF
gene id: 9685:ATP5MF
uniprot id: A0A5F5XP54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9685:PTTG1
gene id: 9685:PTTG1
uniprot id: M3X3A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9685:SPAST
gene id: 9685:SPAST
uniprot id: A0A2I2U639
uniprot id: M3X3B7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

9685:KRT71
gene id: 9685:KRT71
uniprot id: E1AB55
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A complex variation, consisting of an 81-bp deletion, including the last 4 bp of intron 6 and the first 77 bp of exon 7, followed by 2 insertions was identified. This variation was called Rex polymorphism or 'Re'. All sequenced Devon Rex cats, a breed characterized by curly hair phenotype, were homozygous for this variation and loss of homozygosity was associated with normal hair production (PubMed:20953787). A variation affecting the 5'-splice site at the junction of exon 4 and intron 4 was identified in 2 breeds, Sphynx and Kohana, that are characterized by a hairless phenotype. This variation occurred in the heterozygous or homozygous state in these breeds. It has been called hairless or hr allele and has been suggested of a cause of the hairless phenotype (PubMed:20953787).
messages: Belongs to the intermediate filament family.
messages: Heterodimer of a type I and a type II keratin. Associates with KRT16 and/or KRT17 (By similarity).
messages: Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.
messages: cytoskeleton

9685:FXYD1
gene id: 9685:FXYD1
uniprot id: A0A5F5XLQ4
names: Similarity
messages: Belongs to the FXYD family.

9685:CRYZ
gene id: 9685:CRYZ
uniprot id: M3XG55
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9685:LOC101099411
gene id: 9685:LOC101099411
uniprot id: M3X7T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:BPIFC
gene id: 9685:BPIFC
uniprot id: M3WC54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9685:TDP1
gene id: 9685:TDP1
uniprot id: A0A2I2U2A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9685:CLDN4
gene id: 9685:CLDN4
uniprot id: M3W2R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:KCNF1
gene id: 9685:KCNF1
uniprot id: M3XEL1
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101087209
gene id: 9685:LOC101087209
uniprot id: M3WTX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SLC6A4
gene id: 9685:SLC6A4
uniprot id: M3W4Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: focal adhesion

9685:ATP6V1G2
gene id: 9685:ATP6V1G2
uniprot id: A0A337S9H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9685:HPSE2
gene id: 9685:HPSE2
uniprot id: A0A337SDJ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9685:RPL34
gene id: 9685:RPL34
uniprot id: M3WMR1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9685:A2M
gene id: 9685:A2M
uniprot id: M3WMA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9685:KEF43 p07
gene id: 9685:KEF43_p07
uniprot id: P48892
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9685:RCL1
gene id: 9685:RCL1
uniprot id: M3WKX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

9685:GKAP1
gene id: 9685:GKAP1
uniprot id: M3X912
names: Similarity
messages: Belongs to the GKAP1 family.

9685:LOC101092641
gene id: 9685:LOC101092641
uniprot id: M3WXS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ETFB
gene id: 9685:ETFB
uniprot id: M3VZA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9685:SYBU
gene id: 9685:SYBU
uniprot id: M3XCK1
names: Subcellular Location Annotation
messages: Membrane

9685:EPHB4
gene id: 9685:EPHB4
uniprot id: A0A2I2V293
uniprot id: M3W6L6
names: Subcellular Location Annotation
messages: Membrane

9685:SLC39A12
gene id: 9685:SLC39A12
uniprot id: A0A2I2UA85
uniprot id: A0A337SUJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9685:PTPN1
gene id: 9685:PTPN1
uniprot id: M3W194
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9685:DOP1A
gene id: 9685:DOP1A
uniprot id: A0A2I2U9V7
uniprot id: A0A2I2UM74
uniprot id: M3W4K2
names: Similarity
messages: Belongs to the dopey family.

9685:SLC27A6
gene id: 9685:SLC27A6
uniprot id: M3WAX4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9685:GTF3C5
gene id: 9685:GTF3C5
uniprot id: M3W748
names: Subcellular Location Annotation
messages: Nucleus

9685:CWF19L1
gene id: 9685:CWF19L1
uniprot id: M3WDJ5
names: Similarity
messages: Belongs to the CWF19 family.

9685:SGF29
gene id: 9685:SGF29
uniprot id: M3WGP2
names: Subcellular Location Annotation
messages: Nucleus

9685:VPS26A
gene id: 9685:VPS26A
uniprot id: A0A337S4V0
uniprot id: M3XEG2
names: Similarity
messages: Belongs to the VPS26 family.

9685:KIF6
gene id: 9685:KIF6
uniprot id: A0A2I2UB30
uniprot id: A0A2I2V1J7
uniprot id: M3W5V4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:SULF1
gene id: 9685:SULF1
uniprot id: A0A2I2U7J5
uniprot id: M3WGN2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9685:RANBP6
gene id: 9685:RANBP6
uniprot id: A0A337RY96
names: Subcellular Location Annotation
messages: Cytoplasm

9685:DDX3X
gene id: 9685:DDX3X
uniprot id: M3WY95
names: Similarity
messages: Belongs to the DEAD box helicase family.

9685:HAPLN1
gene id: 9685:HAPLN1
uniprot id: A0A337SSS2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9685:LCTL
gene id: 9685:LCTL
uniprot id: M3WGP3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9685:SUCLG1
gene id: 9685:SUCLG1
uniprot id: M3W3J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9685:ARHGAP26
gene id: 9685:ARHGAP26
uniprot id: A0A5F5XD76
uniprot id: A0A5F5Y3T2
uniprot id: M3WAU9
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9685:ABT1
gene id: 9685:ABT1
uniprot id: M3X6Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

9685:PDK1
gene id: 9685:PDK1
uniprot id: M3XE07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9685:LOC101099681
gene id: 9685:LOC101099681
uniprot id: M3X1Q1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TLR7
gene id: 9685:TLR7
uniprot id: A1XC22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane
messages: phagosome

9685:TMEM53
gene id: 9685:TMEM53
uniprot id: M3W7G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9685:RIN2
gene id: 9685:RIN2
uniprot id: A0A2I2V415
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9685:GTF2I
gene id: 9685:GTF2I
uniprot id: A0A2I2U478
uniprot id: A0A2I2UQH5
uniprot id: A0A5F5Y4L6
uniprot id: M3VYU6
names: Subcellular Location Annotation
messages: Nucleus

9685:WDR82
gene id: 9685:WDR82
uniprot id: M3X596
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9685:SLC30A5
gene id: 9685:SLC30A5
uniprot id: M3W954
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9685:LOC101080445
gene id: 9685:LOC101080445
uniprot id: M3WYZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LIMS1
gene id: 9685:LIMS1
uniprot id: A0A337SJ16
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9685:SMPD2
gene id: 9685:SMPD2
uniprot id: M3W5S2
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9685:DDAH2
gene id: 9685:DDAH2
uniprot id: M3XC02
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9685:TINAG
gene id: 9685:TINAG
uniprot id: M3WAV9
names: Similarity
messages: Belongs to the peptidase C1 family.

9685:BEST1
gene id: 9685:BEST1
uniprot id: A0A5F5XG26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9685:TBX6
gene id: 9685:TBX6
uniprot id: A0A337SF13
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:CDC25A
gene id: 9685:CDC25A
uniprot id: A0A2I2UB12
uniprot id: M3WA86
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9685:MCIDAS
gene id: 9685:MCIDAS
uniprot id: A0A2I2V4P7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the geminin family.
messages: Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.
messages: Nucleus

9685:LOC101089822
gene id: 9685:LOC101089822
uniprot id: A0A1K0FUL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9685:BAAT
gene id: 9685:BAAT
uniprot id: M3WV30
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9685:UCK2
gene id: 9685:UCK2
uniprot id: M3WW08
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family.
messages: Homotetramer.

9685:MYO7A
gene id: 9685:MYO7A
uniprot id: A0A2I2U0R3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9685:WWOX
gene id: 9685:WWOX
uniprot id: M3WHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9685:ZHX2
gene id: 9685:ZHX2
uniprot id: M3WR26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9685:INO80D
gene id: 9685:INO80D
uniprot id: M3X6W9
names: Subcellular Location Annotation
messages: Nucleus

9685:DNAJC24
gene id: 9685:DNAJC24
uniprot id: M3X0L0
names: Similarity
messages: Belongs to the DPH4 family.

9685:SERPINB3
gene id: 9685:SERPINB3
uniprot id: M3W9H3
names: Similarity
messages: Belongs to the serpin family.

9685:NR6A1
gene id: 9685:NR6A1
uniprot id: A0A5F5XWG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9685:PHACTR3
gene id: 9685:PHACTR3
uniprot id: A0A337S3B2
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9685:ATM
gene id: 9685:ATM
uniprot id: A0A2I2U0F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Cytoplasmic vesicle
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks.

9685:TMEM63C
gene id: 9685:TMEM63C
uniprot id: M3WFM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9685:EFS
gene id: 9685:EFS
uniprot id: M3X1T8
names: Similarity
messages: Belongs to the CAS family.

9685:ASPDH
gene id: 9685:ASPDH
uniprot id: M3WLS9
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9685:LOC101101260
gene id: 9685:LOC101101260
uniprot id: M3WXH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PTPRM
gene id: 9685:PTPRM
uniprot id: A0A5F5XET7
uniprot id: A0A5F5XFK5
uniprot id: M3WI26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9685:DDB1
gene id: 9685:DDB1
uniprot id: M3XDV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9685:SLC27A1
gene id: 9685:SLC27A1
uniprot id: M3W7U2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9685:MRPL54
gene id: 9685:MRPL54
uniprot id: M3W769
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9685:AHR
gene id: 9685:AHR
uniprot id: M3W3B4
names: Subcellular Location Annotation
messages: Cytoplasm

9685:DSEL
gene id: 9685:DSEL
uniprot id: A0A5F5Y3C0
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9685:BCDIN3D
gene id: 9685:BCDIN3D
uniprot id: M3WBG8
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9685:SLC25A37
gene id: 9685:SLC25A37
uniprot id: M3W411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:CD9
gene id: 9685:CD9
uniprot id: P40239
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (By similarity). Interacts with integrin ITGA6:ITGB1; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). Part of integrin-tetraspanin complexes composed of CD81, beta-1 and beta-2 integrins in the membrane of monocyte/macrophages (By similarity). Interacts with CD63; identified in a complex with CD63 and ITGB3. Associates with CR2/CD21 and with PTGFRN/CD9P1. Part of a complex composed of CD9, CD81, PTGFRN and IGSF8 (By similarity). Interacts directly with IGSF8. Interacts with PDPN; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Interacts (on T cell side) with CD81 at immunological synapses between antigen-presenting cells and T cells (By similarity).
messages: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity).
messages: Membrane
messages: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion.
messages: extracellular exosome

9685:CDC123
gene id: 9685:CDC123
uniprot id: A0A2I2UUM3
uniprot id: A0A337SI74
uniprot id: M3X1J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9685:LOC101098086
gene id: 9685:LOC101098086
uniprot id: A0A2I2UQ06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC102899212
gene id: 9685:LOC102899212
uniprot id: A0A5F5XPF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a ligand for KLRK1.
messages: Belongs to the NKG2D ligand family.
messages: Cell membrane
messages: Membrane

9685:LOC101096808
gene id: 9685:LOC101096808
uniprot id: M3XB45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:ACTL6B
gene id: 9685:ACTL6B
uniprot id: M3W6L2
names: Similarity
messages: Belongs to the actin family.

9685:GABRG3
gene id: 9685:GABRG3
uniprot id: M3X5P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:CRYBA2
gene id: 9685:CRYBA2
uniprot id: M3W7S8
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9685:TSPAN8
gene id: 9685:TSPAN8
uniprot id: A0A2I2UB49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:HBP1
gene id: 9685:HBP1
uniprot id: A0A5F5XPK3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9685:GALT
gene id: 9685:GALT
uniprot id: M3WNC7
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9685:LOC101088237
gene id: 9685:LOC101088237
uniprot id: A0A337SD17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:MEOX2
gene id: 9685:MEOX2
uniprot id: M3WPT8
names: Subcellular Location Annotation
messages: Nucleus

9685:IFNGR1
gene id: 9685:IFNGR1
uniprot id: M3XA82
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9685:THOC5
gene id: 9685:THOC5
uniprot id: M3W1U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9685:OPLAH
gene id: 9685:OPLAH
uniprot id: M3WFA2
names: Similarity
messages: Belongs to the oxoprolinase family.

9685:KCNK10
gene id: 9685:KCNK10
uniprot id: M3VWM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9685:PPP1R9B
gene id: 9685:PPP1R9B
uniprot id: M3WXL9
names: Subcellular Location Annotation
messages: cytoskeleton

9685:NDUFB3
gene id: 9685:NDUFB3
uniprot id: M3X4G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9685:LDHC
gene id: 9685:LDHC
uniprot id: A0A2I2U4Z0
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9685:SLC5A6
gene id: 9685:SLC5A6
uniprot id: M3W3K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9685:RARA
gene id: 9685:RARA
uniprot id: A0A2I2USN5
uniprot id: M3WWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9685:WDR55
gene id: 9685:WDR55
uniprot id: M3WSI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9685:DCLRE1B
gene id: 9685:DCLRE1B
uniprot id: A0A2I2UH02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9685:LOC101085947
gene id: 9685:LOC101085947
uniprot id: A0A5F5XF81
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9685:AFP
gene id: 9685:AFP
uniprot id: M3X557
names: Subcellular Location Annotation
messages: Secreted

9685:LOC101088996
gene id: 9685:LOC101088996
uniprot id: O19434
names: Similarity
messages: Belongs to the MHC class II family.

9685:CCR4
gene id: 9685:CCR4
uniprot id: M3VZE0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:ZNF165
gene id: 9685:ZNF165
uniprot id: M3W0N3
names: Subcellular Location Annotation
messages: Nucleus

9685:NKTR
gene id: 9685:NKTR
uniprot id: A0A337SDZ8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9685:LOC101093971
gene id: 9685:LOC101093971
uniprot id: M3WJI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PIK3CA
gene id: 9685:PIK3CA
uniprot id: A0A2I2UYM7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9685:GAPDH
gene id: 9685:GAPDH
uniprot id: A0A0A0MPZ5
uniprot id: Q9N2D5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Glyceraldehyde-3-phosphate dehydrogenase activity is inhibited by fumarate, via the formation of S-(2-succinyl)cysteine residues.
messages: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
messages: Homotetramer (By similarity). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1. Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity. Interacts with TRAF2, promoting TRAF2 ubiquitination. Interacts with TRAF3, promoting TRAF3 ubiquitination (By similarity).
messages: Homotetramer.
messages: ISGylated.
messages: Nucleus
messages: Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation.
messages: S-nitrosylation of Cys-150 leads to interaction with SIAH1, followed by translocation to the nucleus S-nitrosylation of Cys-245 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (By similarity).
messages: Sulfhydration at Cys-150 increases catalytic activity.
messages: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
messages: cytoskeleton
messages: cytosol

9685:THBS1
gene id: 9685:THBS1
uniprot id: M3WF45
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:RIDA
gene id: 9685:RIDA
uniprot id: A0A2I2UD52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9685:CORIN
gene id: 9685:CORIN
uniprot id: M3W5B9
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:TPPP3
gene id: 9685:TPPP3
uniprot id: M3WB48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: cytoskeleton

9685:JAK1
gene id: 9685:JAK1
uniprot id: A0A2I2U8B7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9685:CAV1
gene id: 9685:CAV1
uniprot id: A0M8S7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: Membrane raft
messages: Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.
messages: caveola

9685:AGPAT5
gene id: 9685:AGPAT5
uniprot id: M3WJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9685:LOC101083797
gene id: 9685:LOC101083797
uniprot id: M3X583
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101094129
gene id: 9685:LOC101094129
uniprot id: M3X2U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101098422
gene id: 9685:LOC101098422
uniprot id: A0A2I2V470
uniprot id: M3X0L4
names: Similarity
messages: Belongs to the NXPE family.

9685:NR4A2
gene id: 9685:NR4A2
uniprot id: M3WFK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9685:PTX4
gene id: 9685:PTX4
uniprot id: A0A337SS86
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CE3H16orf58
gene id: 9685:CE3H16orf58
uniprot id: A0A337SA82
uniprot id: M3XBD1
names: Similarity
messages: Belongs to the RUS1 family.

9685:LOC101082634
gene id: 9685:LOC101082634
uniprot id: A0A2I2USQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MED12L
gene id: 9685:MED12L
uniprot id: A0A337S845
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

9685:CAPN7
gene id: 9685:CAPN7
uniprot id: M3XEV5
names: Similarity
messages: Belongs to the peptidase C2 family.

9685:HVCN1
gene id: 9685:HVCN1
uniprot id: M3X2E4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9685:AK6
gene id: 9685:AK6
uniprot id: M3X272
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9685:UBA7
gene id: 9685:UBA7
uniprot id: G3XKQ8
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9685:NRP2
gene id: 9685:NRP2
uniprot id: M3VUQ9
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:BMI1
gene id: 9685:BMI1
uniprot id: Q9TST0
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of a PRC1-like complex. Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2. Interacts with RNF2/RING2 (By similarity). Interacts with RING1 (By similarity). Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. Interacts with CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. Interacts with PHC2 (By similarity). Interacts with zinc finger protein ZNF277 (By similarity). May be part of a complex including at least ZNF277, BMI1 and RNF2/RING2 (By similarity).
messages: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.
messages: Cytoplasm
messages: Down-regulated by oxidative stress.
messages: May be polyubiquitinated; which does not lead to proteasomal degradation. Monoubiquitinated.
messages: Nucleus
messages: Transcripts are found in thymic lymphomas bearing insertions of the gene. Transcription is low or undetectable in mid-gestational fetal liver, neonatal and adult spleen, and in healthy lymph nodes.

9685:PARL
gene id: 9685:PARL
uniprot id: M3VZR3
names: Subcellular Location Annotation
messages: Membrane

9685:CORO2A
gene id: 9685:CORO2A
uniprot id: M3WS87
names: Similarity
messages: Belongs to the WD repeat coronin family.

9685:KCNH5
gene id: 9685:KCNH5
uniprot id: M3WD34
names: Subcellular Location Annotation
messages: Membrane

9685:SH3RF2
gene id: 9685:SH3RF2
uniprot id: M3WA34
names: Similarity
messages: Belongs to the SH3RF family.

9685:EFTUD2
gene id: 9685:EFTUD2
uniprot id: M3W441
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Nucleus

9685:MALL
gene id: 9685:MALL
uniprot id: A0A2I2UXL8
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101099914
gene id: 9685:LOC101099914
uniprot id: M3X2Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RBM5
gene id: 9685:RBM5
uniprot id: M3WL23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9685:ACTA2
gene id: 9685:ACTA2
uniprot id: M3W7A1
names: Similarity
messages: Belongs to the actin family.

9685:MICOS10
gene id: 9685:MICOS10
uniprot id: M3VZN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9685:KCNB2
gene id: 9685:KCNB2
uniprot id: M3WH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon

9685:SPCS1
gene id: 9685:SPCS1
uniprot id: M3WUM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:TRMT1L
gene id: 9685:TRMT1L
uniprot id: M3WET9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

9685:CBFA2T2
gene id: 9685:CBFA2T2
uniprot id: A0A337S063
names: Similarity
messages: Belongs to the CBFA2T family.

9685:PHOSPHO2
gene id: 9685:PHOSPHO2
uniprot id: M3WX35
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9685:LAMP2
gene id: 9685:LAMP2
uniprot id: M3X6R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9685:MZF1
gene id: 9685:MZF1
uniprot id: A0A5F5Y6Z6
uniprot id: M3W0X0
names: Subcellular Location Annotation
messages: Nucleus

9685:ADGRD1
gene id: 9685:ADGRD1
uniprot id: A0A2I2U423
uniprot id: M3WKI7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:WBP4
gene id: 9685:WBP4
uniprot id: A0A2I2USJ7
names: Subcellular Location Annotation
messages: Nucleus

9685:HOXC12
gene id: 9685:HOXC12
uniprot id: M3X3D7
names: Subcellular Location Annotation
messages: Nucleus

9685:GNG3
gene id: 9685:GNG3
uniprot id: A0A2I2ULW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9685:ETF1
gene id: 9685:ETF1
uniprot id: M3WU44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9685:LAMP1
gene id: 9685:LAMP1
uniprot id: C6GGN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9685:BLK
gene id: 9685:BLK
uniprot id: M3WLI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9685:AP3M2
gene id: 9685:AP3M2
uniprot id: A0A337RT59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9685:ATP2A3
gene id: 9685:ATP2A3
uniprot id: A0A337SUB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9685:SIN3A
gene id: 9685:SIN3A
uniprot id: M3WEZ5
names: Subcellular Location Annotation
messages: Nucleus

9685:CF1H1orf43
gene id: 9685:CF1H1orf43
uniprot id: M3WH87
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9685:LOC101089717
gene id: 9685:LOC101089717
uniprot id: M3W698
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CHST8
gene id: 9685:CHST8
uniprot id: M3XD93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:BDH1
gene id: 9685:BDH1
uniprot id: A0A5F5Y6J3
uniprot id: M3WPA3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:TAAR1
gene id: 9685:TAAR1
uniprot id: M3XEU0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:HMGCL
gene id: 9685:HMGCL
uniprot id: M3WFT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9685:SLC18A3
gene id: 9685:SLC18A3
uniprot id: A0A5F5XCI7
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101101223
gene id: 9685:LOC101101223
uniprot id: M3X9C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:FELCATV1R12
gene id: 9685:FELCATV1R12
uniprot id: A0A0A0Y877
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:FXYD2
gene id: 9685:FXYD2
uniprot id: A0A2I2U2J8
uniprot id: A0A5F5Y0E2
names: Similarity
messages: Belongs to the FXYD family.

9685:NUP205
gene id: 9685:NUP205
uniprot id: A0A2I2U2F9
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

9685:DNAJA1
gene id: 9685:DNAJA1
uniprot id: A0A2I2U399
names: Subcellular Location Annotation
messages: Membrane

9685:PROK1
gene id: 9685:PROK1
uniprot id: A0A2I2UA70
uniprot id: A0A337STJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9685:TAP1
gene id: 9685:TAP1
uniprot id: M3WC96
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9685:MMRN1
gene id: 9685:MMRN1
uniprot id: M3WI37
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:HADHB
gene id: 9685:HADHB
uniprot id: M3WLM4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9685:ENTPD7
gene id: 9685:ENTPD7
uniprot id: M3WKL5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9685:LAMTOR5
gene id: 9685:LAMTOR5
uniprot id: M3X6X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

9685:SNRPE
gene id: 9685:SNRPE
uniprot id: A0A2I2UMK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9685:TLCD2
gene id: 9685:TLCD2
uniprot id: M3W5M9
names: Subcellular Location Annotation
messages: Membrane

9685:CD4H9orf78
gene id: 9685:CD4H9orf78
uniprot id: M3W2T1
names: Similarity
messages: Belongs to the TLS1 family.

9685:NAV3
gene id: 9685:NAV3
uniprot id: A0A337SBX6
uniprot id: A0A337SN55
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9685:SLC35A4
gene id: 9685:SLC35A4
uniprot id: M3VWC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9685:CDK15
gene id: 9685:CDK15
uniprot id: M3VUX8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:HNRNPA2B1
gene id: 9685:HNRNPA2B1
uniprot id: M3XCQ1
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

9685:MTMR3
gene id: 9685:MTMR3
uniprot id: A0A2I2U3B3
uniprot id: A0A2I2ULX1
uniprot id: A0A2I2V1C5
uniprot id: M3VX73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9685:MAPK10
gene id: 9685:MAPK10
uniprot id: A0A337ST22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9685:PLRG1
gene id: 9685:PLRG1
uniprot id: A0A5F5XJ22
uniprot id: M3WPW2
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9685:HMBS
gene id: 9685:HMBS
uniprot id: D3W810
uniprot id: D3W812
names: Similarity
messages: Belongs to the HMBS family.

9685:ITGB4
gene id: 9685:ITGB4
uniprot id: M3W4M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9685:VEGFA
gene id: 9685:VEGFA
uniprot id: Q95LQ4
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9685:EAF2
gene id: 9685:EAF2
uniprot id: M3WP25
names: Similarity
messages: Belongs to the EAF family.

9685:HOXA6
gene id: 9685:HOXA6
uniprot id: A0A2I2UFH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9685:LPIN1
gene id: 9685:LPIN1
uniprot id: A0A2I2UV17
names: Similarity
messages: Belongs to the lipin family.

9685:LOC101089798
gene id: 9685:LOC101089798
uniprot id: M3X8A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SEC11C
gene id: 9685:SEC11C
uniprot id: A0A2I2UK96
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:RIPPLY1
gene id: 9685:RIPPLY1
uniprot id: A0A2I2URM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9685:OSGEPL1
gene id: 9685:OSGEPL1
uniprot id: A0A337S5E0
uniprot id: M3WMQ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Belongs to the ORM family.
messages: Binds 1 divalent metal cation per subunit.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion
messages: Monomer.
messages: Negative regulator of sphingolipid synthesis.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9685:IFNA7
gene id: 9685:IFNA7
uniprot id: P35849
names: Function
names: Pharmaceutical
names: Similarity
names: Subcellular Location Annotation
messages: Available under the names Virbagen Omega and Intercat. Used in veterinary medicine to treat canine parvovirus, feline leukemia virus and feline immunodeficiency virus infections.
messages: Belongs to the alpha/beta interferon family.
messages: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
messages: Secreted

9685:LXN
gene id: 9685:LXN
uniprot id: M3WIL4
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9685:HOXA1
gene id: 9685:HOXA1
uniprot id: M3W8N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9685:C9
gene id: 9685:C9
uniprot id: M3WI95
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted
messages: Target cell membrane

9685:CDC6
gene id: 9685:CDC6
uniprot id: M3X9D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9685:PLN
gene id: 9685:PLN
uniprot id: M3W4A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

9685:TADA3
gene id: 9685:TADA3
uniprot id: M3WK95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9685:TAF7
gene id: 9685:TAF7
uniprot id: A0A337RTM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9685:ALG3
gene id: 9685:ALG3
uniprot id: M3WNC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:GRM8
gene id: 9685:GRM8
uniprot id: A0A5K1UJJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9685:TRIM45
gene id: 9685:TRIM45
uniprot id: M3W3N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9685:ZER1
gene id: 9685:ZER1
uniprot id: M3W4U4
names: Similarity
messages: Belongs to the zyg-11 family.

9685:NPY2R
gene id: 9685:NPY2R
uniprot id: A0A2I2V4M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:PGAM2
gene id: 9685:PGAM2
uniprot id: M3WYZ8
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9685:TIGD6
gene id: 9685:TIGD6
uniprot id: M3WQ55
names: Subcellular Location Annotation
messages: Nucleus

9685:FLA-I
gene id: 9685:FLA-I
uniprot id: Q30493
names: Similarity
messages: Belongs to the MHC class I family.

9685:LOC101085650
gene id: 9685:LOC101085650
uniprot id: A0A2I2U850
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:GAD2
gene id: 9685:GAD2
uniprot id: M3VYC1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9685:ETS1
gene id: 9685:ETS1
uniprot id: A0A2I2U1T1
uniprot id: A0A2I2U2P4
uniprot id: A0A2I2V4V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9685:BET1
gene id: 9685:BET1
uniprot id: A0A2I2UH39
names: Subcellular Location Annotation
messages: Membrane

9685:DUS3L
gene id: 9685:DUS3L
uniprot id: M3X9U8
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

9685:LOXL2
gene id: 9685:LOXL2
uniprot id: M3WGV4
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9685:SEC22A
gene id: 9685:SEC22A
uniprot id: A0A5K1V296
uniprot id: M3WTX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9685:ESF1
gene id: 9685:ESF1
uniprot id: M3WZT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9685:SCN9A
gene id: 9685:SCN9A
uniprot id: A0A337RVZ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9685:KBTBD8
gene id: 9685:KBTBD8
uniprot id: M3WG05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9685:BMS1
gene id: 9685:BMS1
uniprot id: M3WEP4
names: Subcellular Location Annotation
messages: nucleolus

9685:ADPRM
gene id: 9685:ADPRM
uniprot id: M3W1A4
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9685:DUT
gene id: 9685:DUT
uniprot id: A0A337RVJ5
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

9685:SLC1A5
gene id: 9685:SLC1A5
uniprot id: M3W4L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9685:GBE1
gene id: 9685:GBE1
uniprot id: A0A337SR21
uniprot id: Q6T308
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Binds its carbohydrate substrate close to the active site, but also via regions close to the N-terminus; this may result in increased affinity and therefore increased catalytic efficiency.
messages: Defects in GBE1 are the cause of glycogen storage disease IV (GSD-IV).
messages: Monomer.
messages: Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule.

9685:ARCN1
gene id: 9685:ARCN1
uniprot id: M3WFS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9685:NOP10
gene id: 9685:NOP10
uniprot id: A0A2I2U315
names: Similarity
messages: Belongs to the NOP10 family.

9685:ACTN1
gene id: 9685:ACTN1
uniprot id: A0A2I2UNZ9
uniprot id: A0A2I2V4J9
uniprot id: A0A5F5XDQ3
uniprot id: M3VVH8
names: Similarity
messages: Belongs to the alpha-actinin family.

9685:GMDS
gene id: 9685:GMDS
uniprot id: M3W2U5
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9685:IPO13
gene id: 9685:IPO13
uniprot id: M3W600
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9685:LOC101092708
gene id: 9685:LOC101092708
uniprot id: A0A5K1UH56
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9685:KIN
gene id: 9685:KIN
uniprot id: M3VU97
names: Similarity
messages: Belongs to the KIN17 family.

9685:FUS
gene id: 9685:FUS
uniprot id: M3X5Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9685:ST6GALNAC5
gene id: 9685:ST6GALNAC5
uniprot id: M3X4H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9685:NUDT1
gene id: 9685:NUDT1
uniprot id: A0A2I2UU60
names: Subcellular Location Annotation
messages: Nucleus

9685:SLC25A3
gene id: 9685:SLC25A3
uniprot id: A0A2I2UUV9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9685:RASSF5
gene id: 9685:RASSF5
uniprot id: A0A337SG02
names: Subcellular Location Annotation
messages: cytoskeleton

9685:RPL21
gene id: 9685:RPL21
uniprot id: A0A5K1UH56
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9685:METTL1
gene id: 9685:METTL1
uniprot id: A0A2I2UJG8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with WDR4.
messages: Nucleus
messages: Phosphorylation at Ser-28 inactivates its catalytic activity but does not affect the interaction with WDR4.

9685:ZNF397
gene id: 9685:ZNF397
uniprot id: M3XG48
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101098213
gene id: 9685:LOC101098213
uniprot id: M3X7H4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9685:TMEM256
gene id: 9685:TMEM256
uniprot id: M3WSW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9685:RLN
gene id: 9685:RLN
uniprot id: Q9MYK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Expressed by the placenta. Exclusively detected in cells located in the lamellar placental labyrinth and absent from other placental and non-placental uterine parts.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
messages: Secreted

9685:MED7
gene id: 9685:MED7
uniprot id: M3WLT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9685:TCP11L2
gene id: 9685:TCP11L2
uniprot id: M3WJ71
names: Similarity
messages: Belongs to the TCP11 family.

9685:GPR61
gene id: 9685:GPR61
uniprot id: M3WMW6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:MMP8
gene id: 9685:MMP8
uniprot id: M3WNA0
names: Similarity
messages: Belongs to the peptidase M10A family.

9685:FARSB
gene id: 9685:FARSB
uniprot id: M3X0C2
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

9685:IMMT
gene id: 9685:IMMT
uniprot id: A0A2I2V257
uniprot id: A0A5F5XSJ8
uniprot id: M3WAJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9685:CMTM5
gene id: 9685:CMTM5
uniprot id: A0A337S332
uniprot id: A0A337SJY2
names: Subcellular Location Annotation
messages: Membrane

9685:VPS37A
gene id: 9685:VPS37A
uniprot id: A0A2I2U092
uniprot id: A0A5F5XNT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9685:LOC101094100
gene id: 9685:LOC101094100
uniprot id: M3XFM3
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:ZSCAN12
gene id: 9685:ZSCAN12
uniprot id: M3XC63
names: Subcellular Location Annotation
messages: Nucleus

9685:CUEDC2
gene id: 9685:CUEDC2
uniprot id: M3VWA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9685:CCS
gene id: 9685:CCS
uniprot id: A0A2I2UBN3
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9685:CPNE1
gene id: 9685:CPNE1
uniprot id: A0A2I2V326
names: Similarity
messages: Belongs to the copine family.

9685:SDHAF4
gene id: 9685:SDHAF4
uniprot id: M3WU37
names: Similarity
messages: Belongs to the SDHAF4 family.

9685:MAPK14
gene id: 9685:MAPK14
uniprot id: M3X6W3
uniprot id: M3XAW7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9685:ZNF503
gene id: 9685:ZNF503
uniprot id: M3WCK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

9685:RNPS1
gene id: 9685:RNPS1
uniprot id: A0A337S532
uniprot id: A0A337SJJ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus speckle

9685:ANXA9
gene id: 9685:ANXA9
uniprot id: M3WBV0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9685:LOC101100666
gene id: 9685:LOC101100666
uniprot id: A0A2I2UJC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:KEF43 p03
gene id: 9685:KEF43_p03
uniprot id: P48921
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9685:NUF2
gene id: 9685:NUF2
uniprot id: M3W477
names: Similarity
messages: Belongs to the NUF2 family.

9685:RBM22
gene id: 9685:RBM22
uniprot id: M3WPJ5
names: Similarity
messages: Belongs to the SLT11 family.

9685:MFSD11
gene id: 9685:MFSD11
uniprot id: M3W1T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9685:LOC101091022
gene id: 9685:LOC101091022
uniprot id: M3W226
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9685:PCID2
gene id: 9685:PCID2
uniprot id: A0A337SHN9
uniprot id: M3WKC8
names: Similarity
messages: Belongs to the CSN12 family.

9685:GYS2
gene id: 9685:GYS2
uniprot id: M3WHA7
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9685:CFL1
gene id: 9685:CFL1
uniprot id: M3WIJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: lamellipodium membrane
messages: ruffle membrane

9685:PON3
gene id: 9685:PON3
uniprot id: M3W9B9
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9685:MRPL52
gene id: 9685:MRPL52
uniprot id: M3W680
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9685:ENDOU
gene id: 9685:ENDOU
uniprot id: M3WJV9
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

9685:SLC51A
gene id: 9685:SLC51A
uniprot id: M3W838
names: Subcellular Location Annotation
messages: Membrane

9685:GABRA4
gene id: 9685:GABRA4
uniprot id: M3WNN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:PLXNA2
gene id: 9685:PLXNA2
uniprot id: A0A2I2UUB4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:DTNB
gene id: 9685:DTNB
uniprot id: A0A2I2UNG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9685:DDR1
gene id: 9685:DDR1
uniprot id: A0A337SRG6
names: Subcellular Location Annotation
messages: Membrane

9685:NMBR
gene id: 9685:NMBR
uniprot id: M3XDP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:GORASP2
gene id: 9685:GORASP2
uniprot id: M3WQ88
names: Similarity
messages: Belongs to the GORASP family.

9685:CLDN17
gene id: 9685:CLDN17
uniprot id: M3WXT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:YDJC
gene id: 9685:YDJC
uniprot id: M3W8T1
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

9685:STARD3
gene id: 9685:STARD3
uniprot id: M3WCB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9685:GOT1
gene id: 9685:GOT1
uniprot id: M3X6W4
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9685:MPPED2
gene id: 9685:MPPED2
uniprot id: M3VX47
names: Similarity
messages: Belongs to the UPF0046 family.

9685:NRXN1
gene id: 9685:NRXN1
uniprot id: A0A2I2ULK7
uniprot id: A0A5F5XCG0
uniprot id: A0A5F5XJR2
uniprot id: M3X6J8
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:SAP18
gene id: 9685:SAP18
uniprot id: A0A5F5XFM1
names: Similarity
messages: Belongs to the SAP18 family.

9685:RAP2A
gene id: 9685:RAP2A
uniprot id: A0A2I2UK19
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9685:GTF2F2
gene id: 9685:GTF2F2
uniprot id: M3VXW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9685:SLC10A1
gene id: 9685:SLC10A1
uniprot id: M3WAC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9685:MARS2
gene id: 9685:MARS2
uniprot id: M3XBX3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9685:TYR
gene id: 9685:TYR
uniprot id: P55033
names: Cofactor
names: Function
names: PTM
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allelic variations in TYR may be associated with coat color phenotype in siamese and burmese cats. The coat color trait is autosomal recessive.
messages: Belongs to the tyrosinase family.
messages: Binds 2 copper ions per subunit.
messages: Forms an OPN3-dependent complex with DCT in response to blue light in melanocytes.
messages: Glycosylated.
messages: Melanosome
messages: Melanosome membrane
messages: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity).

9685:MYG1
gene id: 9685:MYG1
uniprot id: A0A337S6B3
names: Similarity
messages: Belongs to the MYG1 family.

9685:PTGER4
gene id: 9685:PTGER4
uniprot id: A0A2I2URK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9685:MAGI2
gene id: 9685:MAGI2
uniprot id: M3WXB8
names: Subcellular Location Annotation
messages: Membrane

9685:CD5
gene id: 9685:CD5
uniprot id: M3WJA0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LOC101095449
gene id: 9685:LOC101095449
uniprot id: M3X457
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TRPV1
gene id: 9685:TRPV1
uniprot id: M3W8M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendritic spine membrane

9685:ELOVL6
gene id: 9685:ELOVL6
uniprot id: A0A2I2UWD2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9685:BBS5
gene id: 9685:BBS5
uniprot id: A0A2I2U646
uniprot id: A0A5F5XJR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9685:GPR171
gene id: 9685:GPR171
uniprot id: M3XC60
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:POLR3C
gene id: 9685:POLR3C
uniprot id: A0A337SJQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9685:ENTPD6
gene id: 9685:ENTPD6
uniprot id: A0A2I2U0Q6
uniprot id: M3XBJ8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9685:NCSTN
gene id: 9685:NCSTN
uniprot id: A0A337S9P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9685:CLDN11
gene id: 9685:CLDN11
uniprot id: M3X7B3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:DGAT2L6
gene id: 9685:DGAT2L6
uniprot id: M3W743
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:OPRL1
gene id: 9685:OPRL1
uniprot id: M3VW58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

9685:NDUFAF1
gene id: 9685:NDUFAF1
uniprot id: M3WH95
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9685:RAD23B
gene id: 9685:RAD23B
uniprot id: M3WPZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9685:NAPB
gene id: 9685:NAPB
uniprot id: A0A337S7C8
uniprot id: A0A337SJ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9685:IFNA8
gene id: 9685:IFNA8
uniprot id: Q863J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9685:NKAP
gene id: 9685:NKAP
uniprot id: M3W237
names: Similarity
messages: Belongs to the NKAP family.

9685:PCYT1A
gene id: 9685:PCYT1A
uniprot id: M3X9J4
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9685:ISOC2
gene id: 9685:ISOC2
uniprot id: M3W4G2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isochorismatase family.
messages: Cytoplasm
messages: Interacts with CDKN2A.
messages: Nucleus

9685:LOC101095681
gene id: 9685:LOC101095681
uniprot id: M3WGU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RRP15
gene id: 9685:RRP15
uniprot id: M3X3T5
names: Similarity
messages: Belongs to the RRP15 family.

9685:CD3H12orf43
gene id: 9685:CD3H12orf43
uniprot id: M3WBT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

9685:PIK3IP1
gene id: 9685:PIK3IP1
uniprot id: M3VWF4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:SLC24A5
gene id: 9685:SLC24A5
uniprot id: M3X5I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9685:GFM2
gene id: 9685:GFM2
uniprot id: A0A2I2V1V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9685:RNF13
gene id: 9685:RNF13
uniprot id: M3WD03
names: Subcellular Location Annotation
messages: Membrane

9685:MED4
gene id: 9685:MED4
uniprot id: M3WMD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9685:POT1
gene id: 9685:POT1
uniprot id: M3X4B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9685:SCAMP1
gene id: 9685:SCAMP1
uniprot id: M3W8E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9685:PDGFRA
gene id: 9685:PDGFRA
uniprot id: M3WAV8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9685:LOC101084856
gene id: 9685:LOC101084856
uniprot id: M3W659
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PSMB3
gene id: 9685:PSMB3
uniprot id: M3WKT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9685:FLI1
gene id: 9685:FLI1
uniprot id: A0A2I2UGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:STC2
gene id: 9685:STC2
uniprot id: M3WZL4
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9685:PTGDS
gene id: 9685:PTGDS
uniprot id: Q29487
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: Golgi apparatus
messages: Monomer.
messages: N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. N-glycan at Asn-78: dHex1Hex5HexNAc4. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present.
messages: Nucleus membrane
messages: Rough endoplasmic reticulum
messages: Secreted
messages: perinuclear region

9685:LOC101097942
gene id: 9685:LOC101097942
uniprot id: M3XFW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PPP2R2C
gene id: 9685:PPP2R2C
uniprot id: A0A337SFB7
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9685:PRPS2
gene id: 9685:PRPS2
uniprot id: M3WGN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9685:HS3ST5
gene id: 9685:HS3ST5
uniprot id: M3WSU2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9685:HAS2
gene id: 9685:HAS2
uniprot id: A0A2I2UKQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

9685:TMEM91
gene id: 9685:TMEM91
uniprot id: M3WTE0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9685:AP1M2
gene id: 9685:AP1M2
uniprot id: M3W1V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9685:WNT10A
gene id: 9685:WNT10A
uniprot id: A0A2I2U6E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9685:ST8SIA3
gene id: 9685:ST8SIA3
uniprot id: M3WEJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9685:PIM2
gene id: 9685:PIM2
uniprot id: M3X0B0
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9685:MRPL11
gene id: 9685:MRPL11
uniprot id: M3X718
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9685:EPO
gene id: 9685:EPO
uniprot id: P33708
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
messages: Secreted

9685:ADHFE1
gene id: 9685:ADHFE1
uniprot id: A0A5F5XEU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9685:SMC1A
gene id: 9685:SMC1A
uniprot id: M3WJP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9685:UTP25
gene id: 9685:UTP25
uniprot id: M3WM07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9685:SPOPL
gene id: 9685:SPOPL
uniprot id: A0A2I2V333
names: Similarity
messages: Belongs to the Tdpoz family.

9685:AVIL
gene id: 9685:AVIL
uniprot id: M3WL69
names: Similarity
messages: Belongs to the villin/gelsolin family.

9685:TGFB2
gene id: 9685:TGFB2
uniprot id: A0A2I2U200
uniprot id: A0A2I2UJQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9685:RALY
gene id: 9685:RALY
uniprot id: A0A2I2U159
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9685:PTPRB
gene id: 9685:PTPRB
uniprot id: A0A2I2UMZ2
uniprot id: A0A5F5XP09
uniprot id: M3WCC4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9685:SLC35E4
gene id: 9685:SLC35E4
uniprot id: M3W1K1
names: Subcellular Location Annotation
messages: Membrane

9685:DBT
gene id: 9685:DBT
uniprot id: M3XBZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9685:HKDC1
gene id: 9685:HKDC1
uniprot id: M3W345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9685:HAT1
gene id: 9685:HAT1
uniprot id: M3VYK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9685:CTC1
gene id: 9685:CTC1
uniprot id: A0A5F5XWR4
uniprot id: M3VX21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9685:DGAT2
gene id: 9685:DGAT2
uniprot id: A0A2I2UVU3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:ASIC3
gene id: 9685:ASIC3
uniprot id: A0A2I2URX4
uniprot id: M3WNS3
names: Subcellular Location Annotation
messages: Membrane

9685:TRAPPC1
gene id: 9685:TRAPPC1
uniprot id: M3WYU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9685:NUP35
gene id: 9685:NUP35
uniprot id: A0A2I2UGB5
uniprot id: M3WUA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9685:ANO9
gene id: 9685:ANO9
uniprot id: A0A2I2U1T0
uniprot id: A0A337SQ10
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:GALNT18
gene id: 9685:GALNT18
uniprot id: M3VY51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9685:EMP3
gene id: 9685:EMP3
uniprot id: A0A2I2V3X9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9685:LOC105260995
gene id: 9685:LOC105260995
uniprot id: M3X6D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SELENBP1
gene id: 9685:SELENBP1
uniprot id: M3VXE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9685:SCN3B
gene id: 9685:SCN3B
uniprot id: M3VUR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9685:PNP
gene id: 9685:PNP
uniprot id: M3W6S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9685:PEX14
gene id: 9685:PEX14
uniprot id: A0A2I2UBI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

9685:TNFAIP6
gene id: 9685:TNFAIP6
uniprot id: M3XAE8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CFAP126
gene id: 9685:CFAP126
uniprot id: M3WN90
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9685:RNF111
gene id: 9685:RNF111
uniprot id: A0A2I2UEW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

9685:SLC39A2
gene id: 9685:SLC39A2
uniprot id: A0A2I2UNV3
names: Subcellular Location Annotation
messages: Membrane

9685:TMBIM6
gene id: 9685:TMBIM6
uniprot id: M3WBG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9685:ELN
gene id: 9685:ELN
uniprot id: A0A5F5XF99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elastin family.
messages: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle.
messages: extracellular matrix

9685:NPY4R2
gene id: 9685:NPY4R2
uniprot id: M3X9R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9685:INIP
gene id: 9685:INIP
uniprot id: A0A2I2V4C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9685:ZKSCAN5
gene id: 9685:ZKSCAN5
uniprot id: A0A5F5Y5I2
names: Subcellular Location Annotation
messages: Nucleus

9685:LRCH1
gene id: 9685:LRCH1
uniprot id: P41737
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.
messages: Cytoplasm
messages: Interacts (via LRR repeats) with unphosphorylated DOCK8 (via DHR-2 domain); the interaction prevents the interaction between DOCK8 and CDC42.

9685:FOXI1
gene id: 9685:FOXI1
uniprot id: M3VVI1
names: Subcellular Location Annotation
messages: Nucleus

9685:FELCATV1R4
gene id: 9685:FELCATV1R4
uniprot id: A0A5F5XUT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:OTUD7B
gene id: 9685:OTUD7B
uniprot id: M3WCQ0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9685:LOC101083228
gene id: 9685:LOC101083228
uniprot id: M3WNT2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9685:DERL3
gene id: 9685:DERL3
uniprot id: A0A2I2UMH5
uniprot id: A0A337S838
uniprot id: M3W1I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9685:F10
gene id: 9685:F10
uniprot id: M3WKC7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:LOC101100766
gene id: 9685:LOC101100766
uniprot id: M3VUD6
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9685:SASS6
gene id: 9685:SASS6
uniprot id: M3X538
names: Subcellular Location Annotation
messages: centrosome

9685:AIG1
gene id: 9685:AIG1
uniprot id: A0A337SE38
uniprot id: A0A5F5Y0V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9685:SERPINE1
gene id: 9685:SERPINE1
uniprot id: M3W4Q4
names: Similarity
messages: Belongs to the serpin family.

9685:CYP1A2
gene id: 9685:CYP1A2
uniprot id: A0A0A0MPX5
uniprot id: Q5KQT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation.
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.
messages: Membrane
messages: Microsome membrane

9685:PPP1R2
gene id: 9685:PPP1R2
uniprot id: M3WWT7
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9685:TMEM87B
gene id: 9685:TMEM87B
uniprot id: M3W8Y4
names: Subcellular Location Annotation
messages: Membrane

9685:CCND3
gene id: 9685:CCND3
uniprot id: A0A2I2V351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9685:SMPDL3A
gene id: 9685:SMPDL3A
uniprot id: M3WFD8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9685:MLF1
gene id: 9685:MLF1
uniprot id: A0A337SDK2
uniprot id: M3WR71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9685:LIG3
gene id: 9685:LIG3
uniprot id: A0A2I2UG83
uniprot id: A0A5F5XPL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9685:PHLDA1
gene id: 9685:PHLDA1
uniprot id: M3XA40
names: Subcellular Location Annotation
messages: Cytoplasm

9685:NPC1
gene id: 9685:NPC1
uniprot id: Q9N0Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9685:LOC101085800
gene id: 9685:LOC101085800
uniprot id: M3X0Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:POLE2
gene id: 9685:POLE2
uniprot id: M3WAU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

9685:TNFSF13
gene id: 9685:TNFSF13
uniprot id: D2ITC1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9685:TNRC6A
gene id: 9685:TNRC6A
uniprot id: A0A2I2US95
uniprot id: A0A5F5XLL1
uniprot id: A0A5F5Y1J3
names: Similarity
messages: Belongs to the GW182 family.

9685:LOC101094096
gene id: 9685:LOC101094096
uniprot id: A0A337SE00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9685:GFM1
gene id: 9685:GFM1
uniprot id: M3WIL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9685:SLC46A3
gene id: 9685:SLC46A3
uniprot id: M3W974
names: Subcellular Location Annotation
messages: Membrane

9685:ARG1
gene id: 9685:ARG1
uniprot id: M3VXU3
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9685:CACNB4
gene id: 9685:CACNB4
uniprot id: A0A337SFX8
uniprot id: M3X185
uniprot id: M3XBX7
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9685:TOMT
gene id: 9685:TOMT
uniprot id: A0A337S8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Endoplasmic reticulum

9685:LOC101100475
gene id: 9685:LOC101100475
uniprot id: M3WUJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:NOP14
gene id: 9685:NOP14
uniprot id: M3W2I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9685:RPL41
gene id: 9685:RPL41
uniprot id: P62946
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

9685:CCR5
gene id: 9685:CCR5
uniprot id: Q867D6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:TACC2
gene id: 9685:TACC2
uniprot id: M3X454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9685:NTNG1
gene id: 9685:NTNG1
uniprot id: A0A2I2U821
uniprot id: A0A2I2UY83
uniprot id: A0A337SSQ6
uniprot id: A0A5F5XLK0
uniprot id: M3VW60
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:THYN1
gene id: 9685:THYN1
uniprot id: M3W7P7
names: Function
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9685:EIF2S2
gene id: 9685:EIF2S2
uniprot id: M3WX80
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9685:GFUS
gene id: 9685:GFUS
uniprot id: M3VVW7
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9685:ELK1
gene id: 9685:ELK1
uniprot id: M3W951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:LOC493739
gene id: 9685:LOC493739
uniprot id: Q5VFH6
names: Allergen
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant in urine (at protein level).
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Causes an allergic reaction in human. Binds to IgE.
messages: May be a pheromone carrier. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice.
messages: Secreted

9685:TWSG1
gene id: 9685:TWSG1
uniprot id: M3X4Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

9685:KEF43 p01
gene id: 9685:KEF43_p01
uniprot id: P48886
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9685:VPS8
gene id: 9685:VPS8
uniprot id: M3W8E7
names: Similarity
messages: Belongs to the VPS8 family.

9685:TSPAN1
gene id: 9685:TSPAN1
uniprot id: M3VUZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:NPRL2
gene id: 9685:NPRL2
uniprot id: M3VXQ0
names: Similarity
messages: Belongs to the NPR2 family.

9685:PTHLH
gene id: 9685:PTHLH
uniprot id: M3W9D7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9685:TEKT1
gene id: 9685:TEKT1
uniprot id: A0A5F5XVW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9685:MARCO
gene id: 9685:MARCO
uniprot id: M3WJY3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:FTSJ1
gene id: 9685:FTSJ1
uniprot id: M3XEN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

9685:CASP12
gene id: 9685:CASP12
uniprot id: A9YEF1
uniprot id: M3W4Y8
names: Similarity
messages: Belongs to the peptidase C14A family.

9685:RIOX2
gene id: 9685:RIOX2
uniprot id: M3W7I7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. MINA53 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
messages: nucleolus

9685:MAPK4
gene id: 9685:MAPK4
uniprot id: M3WGF3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9685:ENY2
gene id: 9685:ENY2
uniprot id: M3XCF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9685:IMP4
gene id: 9685:IMP4
uniprot id: M3XDW6
names: Subcellular Location Annotation
messages: nucleolus

9685:METTL14
gene id: 9685:METTL14
uniprot id: M3W713
names: Similarity
messages: Belongs to the MT-A70-like family.

9685:BCKDK
gene id: 9685:BCKDK
uniprot id: A0A337SBB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9685:GLB1
gene id: 9685:GLB1
uniprot id: O19015
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 35 family.
messages: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
messages: Homodimer. May form higher multimers.
messages: Lysosome

9685:DLX5
gene id: 9685:DLX5
uniprot id: A0A337S076
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9685:GABRP
gene id: 9685:GABRP
uniprot id: M3W0Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:TP63
gene id: 9685:TP63
uniprot id: A0A2I2UUR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9685:CNTN1
gene id: 9685:CNTN1
uniprot id: A0A2I2UQD8
uniprot id: M3X487
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9685:PPT2
gene id: 9685:PPT2
uniprot id: A0A5F5XW18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Lysosome

9685:SPSB1
gene id: 9685:SPSB1
uniprot id: M3XC71
names: Similarity
messages: Belongs to the SPSB family.

9685:LCK
gene id: 9685:LCK
uniprot id: A0A2I2UG73
uniprot id: A0A2I2V1Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9685:SSTR4
gene id: 9685:SSTR4
uniprot id: M3X0A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:PLXNB1
gene id: 9685:PLXNB1
uniprot id: M3VXW2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:LYPD6
gene id: 9685:LYPD6
uniprot id: A0A2I2U035
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:ALAS1
gene id: 9685:ALAS1
uniprot id: M3WN44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9685:BHMT2
gene id: 9685:BHMT2
uniprot id: A0A2I2UAZ9
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9685:PNPLA4
gene id: 9685:PNPLA4
uniprot id: M3W1J2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:RBBP4
gene id: 9685:RBBP4
uniprot id: M3WS50
names: Subcellular Location Annotation
messages: Nucleus

9685:PRICKLE2
gene id: 9685:PRICKLE2
uniprot id: A0A337S4B0
uniprot id: A0A337SUH8
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9685:MCL1
gene id: 9685:MCL1
uniprot id: Q7YRZ9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Bcl-2 family.
messages: Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment.
messages: Cytoplasm
messages: Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BOK, BIK, BAX, BAK1, and TPT1. Interacts with unphosphorylated BAD (By similarity). Interacts with BMF, BBC3 and PMAIP1 (By similarity). Interacts with BOP (By similarity). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (By similarity). Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and MCL1 is impaired in the absence of GIMAP5 (By similarity).
messages: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity).
messages: Membrane
messages: Mitochondrion
messages: Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites (By similarity).
messages: Rapidly degraded in the absence of phosphorylation in the PEST region.
messages: Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159 (By similarity).
messages: nucleoplasm

9685:FIBIN
gene id: 9685:FIBIN
uniprot id: M3W7G7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9685:CCN1
gene id: 9685:CCN1
uniprot id: M3WX79
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:LETMD1
gene id: 9685:LETMD1
uniprot id: A0A337SF57
names: Subcellular Location Annotation
messages: Membrane

9685:DNAAF1
gene id: 9685:DNAAF1
uniprot id: M3WFB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF1 family.
messages: cilium

9685:CDC5L
gene id: 9685:CDC5L
uniprot id: M3WBP2
names: Similarity
messages: Belongs to the CEF1 family.

9685:SCML2
gene id: 9685:SCML2
uniprot id: A0A5F5XT92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9685:GASK1B
gene id: 9685:GASK1B
uniprot id: A0A2I2U5G6
names: Similarity
messages: Belongs to the GASK family.

9685:LOC101101656
gene id: 9685:LOC101101656
uniprot id: M3XBQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9685:LOC101100726
gene id: 9685:LOC101100726
uniprot id: M3XA47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SLC10A6
gene id: 9685:SLC10A6
uniprot id: M3XET2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9685:B9D2
gene id: 9685:B9D2
uniprot id: A0A2I2U973
names: Subcellular Location Annotation
messages: cilium basal body

9685:CLDN6
gene id: 9685:CLDN6
uniprot id: M3W2L0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:SLC25A20
gene id: 9685:SLC25A20
uniprot id: M3X6S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:ELOVL7
gene id: 9685:ELOVL7
uniprot id: M3WJ50
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9685:TMEM126B
gene id: 9685:TMEM126B
uniprot id: A0A2I2UF27
uniprot id: A0A337SSC1
names: Subcellular Location Annotation
messages: Membrane

9685:ADA
gene id: 9685:ADA
uniprot id: A0A337S152
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasmic vesicle lumen

9685:CHST9
gene id: 9685:CHST9
uniprot id: A0A2I2U3V3
uniprot id: A0A2I2UMT5
uniprot id: A0A337SK30
uniprot id: M3VZS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:CLDN18
gene id: 9685:CLDN18
uniprot id: M3VXB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:APC
gene id: 9685:APC
uniprot id: A0A2I2UXG0
uniprot id: A0A5F5XTX7
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9685:ZDHHC9
gene id: 9685:ZDHHC9
uniprot id: M3WSS0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:RGR
gene id: 9685:RGR
uniprot id: M3VX16
names: Subcellular Location Annotation
messages: Membrane

9685:DNAJC27
gene id: 9685:DNAJC27
uniprot id: A0A2I2USX2
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9685:CAT
gene id: 9685:CAT
uniprot id: M3VXR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

9685:LOC101098399
gene id: 9685:LOC101098399
uniprot id: A0A2I2U7I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RPS9
gene id: 9685:RPS9
uniprot id: M3WJZ7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9685:PHKG2
gene id: 9685:PHKG2
uniprot id: M3WC60
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9685:CCL22
gene id: 9685:CCL22
uniprot id: A0A2I2UXP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:HSPB1
gene id: 9685:HSPB1
uniprot id: M3WWP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9685:SLC5A2
gene id: 9685:SLC5A2
uniprot id: M3VWJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9685:TBCB
gene id: 9685:TBCB
uniprot id: M3X835
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

9685:PRTFDC1
gene id: 9685:PRTFDC1
uniprot id: M3VV03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9685:BRF2
gene id: 9685:BRF2
uniprot id: M3X9N0
names: Similarity
messages: Belongs to the TFIIB family.

9685:SMIM24
gene id: 9685:SMIM24
uniprot id: A0A5F5XSJ1
names: Subcellular Location Annotation
messages: Membrane

9685:GOLPH3L
gene id: 9685:GOLPH3L
uniprot id: A0A2I2UP52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9685:TPI1
gene id: 9685:TPI1
uniprot id: M3X9A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9685:TMEM233
gene id: 9685:TMEM233
uniprot id: A0A2I2V522
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9685:ARL6IP5
gene id: 9685:ARL6IP5
uniprot id: A0A2I2UA23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9685:AQP4
gene id: 9685:AQP4
uniprot id: A0A337SLX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9685:RAB39B
gene id: 9685:RAB39B
uniprot id: A0A2I2UDI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9685:PLA2G15
gene id: 9685:PLA2G15
uniprot id: M3X3D3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9685:TM7SF2
gene id: 9685:TM7SF2
uniprot id: M3W5J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9685:STIM1
gene id: 9685:STIM1
uniprot id: A0A2I2UY42
uniprot id: A0A337SAK7
uniprot id: M3W8F6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:VDR
gene id: 9685:VDR
uniprot id: M3X4E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Nucleus

9685:MCM7
gene id: 9685:MCM7
uniprot id: A0A337S3U9
uniprot id: M3W0J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9685:MMP7
gene id: 9685:MMP7
uniprot id: A0A0A0MQ21
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 calcium ions per subunit.

9685:EMC9
gene id: 9685:EMC9
uniprot id: A0A2I2UJ90
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9685:CXXC1
gene id: 9685:CXXC1
uniprot id: M3W5D0
names: Subcellular Location Annotation
messages: Nucleus

9685:MYOZ1
gene id: 9685:MYOZ1
uniprot id: M3WJ62
names: Similarity
messages: Belongs to the myozenin family.

9685:GGCX
gene id: 9685:GGCX
uniprot id: A0A2I2UMV5
names: Subcellular Location Annotation
messages: Membrane

9685:CBLB
gene id: 9685:CBLB
uniprot id: A0A337SBX7
uniprot id: M3W2E6
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9685:PDGFC
gene id: 9685:PDGFC
uniprot id: A0A5F5XSA6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:NSUN3
gene id: 9685:NSUN3
uniprot id: M3W4Z8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9685:AHSA1
gene id: 9685:AHSA1
uniprot id: M3VX03
names: Similarity
messages: Belongs to the AHA1 family.

9685:MYOZ2
gene id: 9685:MYOZ2
uniprot id: M3VZJ8
names: Similarity
messages: Belongs to the myozenin family.

9685:LOC101091306
gene id: 9685:LOC101091306
uniprot id: M3X6M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GNPDA2
gene id: 9685:GNPDA2
uniprot id: M3X7J4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9685:NXF1
gene id: 9685:NXF1
uniprot id: M3WLB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9685:SLC25A18
gene id: 9685:SLC25A18
uniprot id: M3W8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:FASLG
gene id: 9685:FASLG
uniprot id: Q861W5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Homotrimer. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.
messages: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.
messages: Lysosome lumen
messages: Monoubiquitinated.
messages: N-glycosylated. Glycosylation enhances apoptotic activity.
messages: Nucleus
messages: Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.

9685:NUSAP1
gene id: 9685:NUSAP1
uniprot id: M3WH94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUSAP family.
messages: Cytoplasm

9685:LOC101081645
gene id: 9685:LOC101081645
uniprot id: M3X8V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ERG
gene id: 9685:ERG
uniprot id: A0A2I2UEM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:RAB38
gene id: 9685:RAB38
uniprot id: M3W9L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9685:ADRB3
gene id: 9685:ADRB3
uniprot id: Q9TST4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis (By similarity).
messages: Cell membrane
messages: Interacts with ARRDC3.

9685:ZNF24
gene id: 9685:ZNF24
uniprot id: A0A2I2U772
names: Subcellular Location Annotation
messages: Nucleus

9685:NRDC
gene id: 9685:NRDC
uniprot id: M3X115
names: Similarity
messages: Belongs to the peptidase M16 family.

9685:SLC35F2
gene id: 9685:SLC35F2
uniprot id: A6XMY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9685:GPR50
gene id: 9685:GPR50
uniprot id: A0A337S2D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:GABRA1
gene id: 9685:GABRA1
uniprot id: M3W913
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:FAIM2
gene id: 9685:FAIM2
uniprot id: M3WBH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9685:NUP85
gene id: 9685:NUP85
uniprot id: M3WKU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9685:LOC101095775
gene id: 9685:LOC101095775
uniprot id: A0A2I2U6H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101091569
gene id: 9685:LOC101091569
uniprot id: A0A2I2UYB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9685:CDH10
gene id: 9685:CDH10
uniprot id: M3WYR0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9685:TMEM205
gene id: 9685:TMEM205
uniprot id: A0A337S1G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9685:CHMP4B
gene id: 9685:CHMP4B
uniprot id: M3WXJ4
names: Similarity
messages: Belongs to the SNF7 family.

9685:NQO2
gene id: 9685:NQO2
uniprot id: M3X0S5
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9685:MRAP2
gene id: 9685:MRAP2
uniprot id: A0A2I2UQH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:BCKDHA
gene id: 9685:BCKDHA
uniprot id: M3W423
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of alpha and beta chains.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

9685:RPL23
gene id: 9685:RPL23
uniprot id: M3WKT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9685:GRIN1
gene id: 9685:GRIN1
uniprot id: A0A5F5XFE3
uniprot id: A0A5F5XJZ8
uniprot id: A0A5F5XLT4
uniprot id: A0A5F5XYS8
uniprot id: A0A5F5Y645
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9685:CLDN10
gene id: 9685:CLDN10
uniprot id: A0A337SV17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:SARAF
gene id: 9685:SARAF
uniprot id: A0A2I2URF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9685:B3GALT2
gene id: 9685:B3GALT2
uniprot id: M3XBV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:ARL5B
gene id: 9685:ARL5B
uniprot id: M3WMQ6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9685:SPRY2
gene id: 9685:SPRY2
uniprot id: M3W8A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: ruffle membrane

9685:PGM3
gene id: 9685:PGM3
uniprot id: M3W4K3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

9685:HTR1A
gene id: 9685:HTR1A
uniprot id: M3WJQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
messages: Membrane
messages: dendrite

9685:LOC101099548
gene id: 9685:LOC101099548
uniprot id: M3W900
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9685:FABP2
gene id: 9685:FABP2
uniprot id: M3WQY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cytoplasm
messages: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9685:UQCRC2
gene id: 9685:UQCRC2
uniprot id: M3W8B7
names: Similarity
messages: Belongs to the peptidase M16 family.

9685:MMACHC
gene id: 9685:MMACHC
uniprot id: M3VUA3
names: Similarity
messages: Belongs to the MMACHC family.

9685:HAAO
gene id: 9685:HAAO
uniprot id: M3VUF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9685:ECHDC2
gene id: 9685:ECHDC2
uniprot id: A0A5F5XUV5
uniprot id: M3VXQ6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9685:DUSP9
gene id: 9685:DUSP9
uniprot id: M3W1F9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9685:GANC
gene id: 9685:GANC
uniprot id: M3VZC6
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9685:KLHL3
gene id: 9685:KLHL3
uniprot id: A0A5F5XHH0
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

9685:IFNA5
gene id: 9685:IFNA5
uniprot id: Q8MIL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9685:ACAT1
gene id: 9685:ACAT1
uniprot id: A0A5F5Y1V6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9685:RPS6
gene id: 9685:RPS6
uniprot id: M3VYQ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9685:COG3
gene id: 9685:COG3
uniprot id: M3W302
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9685:GLIPR1
gene id: 9685:GLIPR1
uniprot id: M3W3N0
names: Similarity
messages: Belongs to the CRISP family.

9685:MPDU1
gene id: 9685:MPDU1
uniprot id: A0A337SJN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9685:TMCO5A
gene id: 9685:TMCO5A
uniprot id: M3WKV1
names: Subcellular Location Annotation
messages: Membrane

9685:CAMK2A
gene id: 9685:CAMK2A
uniprot id: A0A2I2V4I2
uniprot id: M3W0P7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9685:HMGCR
gene id: 9685:HMGCR
uniprot id: A0A2I2UV66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

9685:AIMP2
gene id: 9685:AIMP2
uniprot id: M3X664
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9685:ARHGEF12
gene id: 9685:ARHGEF12
uniprot id: A0A2I2UB90
uniprot id: A0A5F5Y739
uniprot id: M3X136
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9685:POC5
gene id: 9685:POC5
uniprot id: M3WBV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POC5 family.
messages: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
messages: centriole

9685:PIGS
gene id: 9685:PIGS
uniprot id: M3W999
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:MUSTN1
gene id: 9685:MUSTN1
uniprot id: A0A337S5P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9685:TDP2
gene id: 9685:TDP2
uniprot id: M3WQI6
names: Subcellular Location Annotation
messages: PML body

9685:CREM
gene id: 9685:CREM
uniprot id: A0A5F5XQ36
names: Subcellular Location Annotation
messages: Nucleus

9685:LACTB2
gene id: 9685:LACTB2
uniprot id: A0A5F5XCK9
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9685:LOC101100266
gene id: 9685:LOC101100266
uniprot id: A0A2I2UCG4
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9685:MYORG
gene id: 9685:MYORG
uniprot id: M3WY70
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9685:RTN3
gene id: 9685:RTN3
uniprot id: M3WQJ1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:NSUN7
gene id: 9685:NSUN7
uniprot id: A0A337SAG4
uniprot id: M3WHQ3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:SLC41A2
gene id: 9685:SLC41A2
uniprot id: A0A5F5Y3S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9685:NAA60
gene id: 9685:NAA60
uniprot id: A0A337S2H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

9685:TIMM21
gene id: 9685:TIMM21
uniprot id: M3X2F7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9685:FAM76B
gene id: 9685:FAM76B
uniprot id: M3XA68
names: Similarity
messages: Belongs to the FAM76 family.

9685:OIP5
gene id: 9685:OIP5
uniprot id: A0A2I2V535
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9685:CERS2
gene id: 9685:CERS2
uniprot id: A0A337SX67
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9685:ARG2
gene id: 9685:ARG2
uniprot id: A0A5F5XPQ8
uniprot id: M3WK19
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9685:SLC16A5
gene id: 9685:SLC16A5
uniprot id: M3WKU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9685:KAT7
gene id: 9685:KAT7
uniprot id: M3VYV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9685:RGS1
gene id: 9685:RGS1
uniprot id: A0A2I2ULH9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

9685:ADRB1
gene id: 9685:ADRB1
uniprot id: Q9TST6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).
messages: Cell membrane
messages: Early endosome
messages: Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
messages: Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4 (By similarity).
messages: The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.

9685:HOMER1
gene id: 9685:HOMER1
uniprot id: M3WN77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9685:GSK3A
gene id: 9685:GSK3A
uniprot id: M3X6U4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9685:ASL
gene id: 9685:ASL
uniprot id: A0A2I2UJE0
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

9685:RBM42
gene id: 9685:RBM42
uniprot id: A0A2I2UCT9
uniprot id: A0A337SHS1
names: Similarity
messages: Belongs to the RRM RBM42 family.

9685:ACAD11
gene id: 9685:ACAD11
uniprot id: M3WUQ8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9685:LOC101080711
gene id: 9685:LOC101080711
uniprot id: A0A5F5XY89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:HCAR2
gene id: 9685:HCAR2
uniprot id: M3WNC8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:ABR
gene id: 9685:ABR
uniprot id: A0A2I2URF9
uniprot id: A0A337S856
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9685:HPDL
gene id: 9685:HPDL
uniprot id: M3X3U1
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9685:PSMA6
gene id: 9685:PSMA6
uniprot id: A0A337SNJ1
uniprot id: A0A337SVW8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9685:PPP3CA
gene id: 9685:PPP3CA
uniprot id: A0A2I2UWL3
uniprot id: A0A337RZJ8
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9685:ADAMTS3
gene id: 9685:ADAMTS3
uniprot id: M3W363
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9685:ELAVL2
gene id: 9685:ELAVL2
uniprot id: A0A2I2UW97
names: Similarity
messages: Belongs to the RRM elav family.

9685:CE2H19orf54
gene id: 9685:CE2H19orf54
uniprot id: M3WP95
names: Similarity
messages: Belongs to the UPF0692 family.

9685:IL7R
gene id: 9685:IL7R
uniprot id: M3WAZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

9685:HDHD3
gene id: 9685:HDHD3
uniprot id: A0A5F5XRE7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9685:MDM4
gene id: 9685:MDM4
uniprot id: M3WLG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

9685:LOC101092025
gene id: 9685:LOC101092025
uniprot id: M3XAG6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:RNF40
gene id: 9685:RNF40
uniprot id: A0A2I2UAJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9685:RBM17
gene id: 9685:RBM17
uniprot id: M3XE89
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9685:FAM187A
gene id: 9685:FAM187A
uniprot id: M3W442
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9685:EIF4EBP3
gene id: 9685:EIF4EBP3
uniprot id: A0A337SDV7
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9685:S100A4
gene id: 9685:S100A4
uniprot id: A0A5F5XHL3
uniprot id: M3WK06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9685:PSMD13
gene id: 9685:PSMD13
uniprot id: M3VYX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9685:TBCCD1
gene id: 9685:TBCCD1
uniprot id: A0A337SSG9
uniprot id: M3WG95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9685:PARP9
gene id: 9685:PARP9
uniprot id: M3VV00
names: Similarity
messages: Belongs to the ARTD/PARP family.

9685:MRPL27
gene id: 9685:MRPL27
uniprot id: A0A2I2UTF3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9685:CSMD3
gene id: 9685:CSMD3
uniprot id: A0A2I2UG55
uniprot id: A0A337SPJ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:ENOPH1
gene id: 9685:ENOPH1
uniprot id: A0A337SNV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9685:ZDHHC8
gene id: 9685:ZDHHC8
uniprot id: A0A2I2U4T9
uniprot id: M3W1Q0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:ACVR1
gene id: 9685:ACVR1
uniprot id: M3W8V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9685:FAR1
gene id: 9685:FAR1
uniprot id: A0A2I2US82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9685:MTHFD1
gene id: 9685:MTHFD1
uniprot id: M3W8F9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9685:EGR1
gene id: 9685:EGR1
uniprot id: A0A2I2U5Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9685:MYO9B
gene id: 9685:MYO9B
uniprot id: M3VVT2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9685:TNFAIP1
gene id: 9685:TNFAIP1
uniprot id: M3X7C4
names: Similarity
messages: Belongs to the BACURD family.

9685:CCN5
gene id: 9685:CCN5
uniprot id: M3VYK2
names: Similarity
messages: Belongs to the CCN family.

9685:MTMR6
gene id: 9685:MTMR6
uniprot id: A0A5F5XQ58
uniprot id: M3WY58
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9685:DHRS7C
gene id: 9685:DHRS7C
uniprot id: M3VXD6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:FGF14
gene id: 9685:FGF14
uniprot id: M3WSV6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9685:DHTKD1
gene id: 9685:DHTKD1
uniprot id: M3WHR8
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9685:CERS5
gene id: 9685:CERS5
uniprot id: M3WBH9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9685:WLS
gene id: 9685:WLS
uniprot id: A0A5F5XS95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9685:MRM2
gene id: 9685:MRM2
uniprot id: M3X7V1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

9685:GGNBP2
gene id: 9685:GGNBP2
uniprot id: A0A2I2V1S6
uniprot id: M3W6Y8
names: Function
messages: May be involved in spermatogenesis.

9685:PPP1CC
gene id: 9685:PPP1CC
uniprot id: M3WEL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cleavage furrow
messages: Midbody
messages: microtubule organizing center
messages: nucleolus
messages: nucleoplasm

9685:CRYGB
gene id: 9685:CRYGB
uniprot id: M3W1B4
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9685:YWHAE
gene id: 9685:YWHAE
uniprot id: A0A337SCS9
names: Similarity
messages: Belongs to the 14-3-3 family.

9685:TLCD3A
gene id: 9685:TLCD3A
uniprot id: A0A337RZ74
names: Subcellular Location Annotation
messages: Membrane

9685:ORC4
gene id: 9685:ORC4
uniprot id: A0A337SL77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9685:PLA2G3
gene id: 9685:PLA2G3
uniprot id: A0A337SPW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9685:LOC101081492
gene id: 9685:LOC101081492
uniprot id: M3WNA2
names: Similarity
messages: Belongs to the peptidase M10A family.

9685:ISY1
gene id: 9685:ISY1
uniprot id: M3W9Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9685:ZNF280C
gene id: 9685:ZNF280C
uniprot id: M3WPH8
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9685:LOC101084446
gene id: 9685:LOC101084446
uniprot id: M3X6T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:DOK2
gene id: 9685:DOK2
uniprot id: M3WAJ3
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9685:TMEM115
gene id: 9685:TMEM115
uniprot id: M3WT82
names: Subcellular Location Annotation
messages: Membrane

9685:IL7
gene id: 9685:IL7
uniprot id: A0A2I2UJP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

9685:CXCR3
gene id: 9685:CXCR3
uniprot id: M3WTQ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

9685:CTSC
gene id: 9685:CTSC
uniprot id: M3W9M0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9685:AP2A2
gene id: 9685:AP2A2
uniprot id: M3WI80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9685:FCER1G
gene id: 9685:FCER1G
uniprot id: A0A2I2V145
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9685:PYGM
gene id: 9685:PYGM
uniprot id: M3WGJ7
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9685:OXSM
gene id: 9685:OXSM
uniprot id: M3WHK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9685:NDUFAF3
gene id: 9685:NDUFAF3
uniprot id: M3WC83
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9685:FAM3D
gene id: 9685:FAM3D
uniprot id: M3W626
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9685:EXOC7
gene id: 9685:EXOC7
uniprot id: A0A2I2U6X6
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9685:ADGRB2
gene id: 9685:ADGRB2
uniprot id: A0A2I2U7T9
uniprot id: A0A2I2UPT2
uniprot id: A0A2I2UZI8
uniprot id: A0A337SKU9
uniprot id: A0A337SR07
uniprot id: M3WN22
names: Subcellular Location Annotation
messages: Membrane

9685:GJC1
gene id: 9685:GJC1
uniprot id: A0A2I2U189
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:SFRP4
gene id: 9685:SFRP4
uniprot id: M3X0E0
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:UPF3B
gene id: 9685:UPF3B
uniprot id: A0A2I2U4P2
uniprot id: M3W236
names: Similarity
messages: Belongs to the RENT3 family.

9685:MSH4
gene id: 9685:MSH4
uniprot id: M3WNH7
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9685:HCCS
gene id: 9685:HCCS
uniprot id: M3XCQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9685:HADHA
gene id: 9685:HADHA
uniprot id: M3WLM2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9685:SLC5A7
gene id: 9685:SLC5A7
uniprot id: M3VWH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9685:CD244
gene id: 9685:CD244
uniprot id: M3W156
names: Subcellular Location Annotation
messages: Membrane

9685:NOXRED1
gene id: 9685:NOXRED1
uniprot id: A0A2I2UB47
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9685:KCNA10
gene id: 9685:KCNA10
uniprot id: M3X5X2
names: Subcellular Location Annotation
messages: Membrane

9685:NEIL1
gene id: 9685:NEIL1
uniprot id: A0A5F5XMH4
uniprot id: M3WEZ0
names: Similarity
messages: Belongs to the FPG family.

9685:MYC
gene id: 9685:MYC
uniprot id: D3U662
uniprot id: P68271
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity). Interacts with CIP2A; leading to the stabilization of MYC (By similarity).
messages: Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.
messages: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.
messages: nucleolus
messages: nucleoplasm

9685:EIF3K
gene id: 9685:EIF3K
uniprot id: A0A337SMZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9685:ATP5PD
gene id: 9685:ATP5PD
uniprot id: M3XC82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9685:ACVR2A
gene id: 9685:ACVR2A
uniprot id: A0A2I2URP7
uniprot id: M3X9E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9685:MUSK
gene id: 9685:MUSK
uniprot id: M3W234
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:VGLL1
gene id: 9685:VGLL1
uniprot id: A0A5F5Y2U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9685:DPEP1
gene id: 9685:DPEP1
uniprot id: M3W0Z1
uniprot id: Q0PDI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
messages: Membrane

9685:FZD4
gene id: 9685:FZD4
uniprot id: A0A2I2UH80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9685:NGLY1
gene id: 9685:NGLY1
uniprot id: A0A337S594
uniprot id: A0A337S5I9
uniprot id: M3WX23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

9685:NR4A1
gene id: 9685:NR4A1
uniprot id: M3VUE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: Cytoplasm
messages: Nucleus

9685:COPS7A
gene id: 9685:COPS7A
uniprot id: M3XEA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9685:RIOK1
gene id: 9685:RIOK1
uniprot id: M3X6D2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9685:FABP3
gene id: 9685:FABP3
uniprot id: M3X9Z0
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9685:ALDH6A1
gene id: 9685:ALDH6A1
uniprot id: A0A5F5XXA6
uniprot id: M3W5H1
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9685:RARS1
gene id: 9685:RARS1
uniprot id: M3WRM0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9685:UFL1
gene id: 9685:UFL1
uniprot id: M3W8F2
names: Similarity
messages: Belongs to the UFL1 family.

9685:C2
gene id: 9685:C2
uniprot id: A0A2I2V4P2
uniprot id: A0A5F5XU26
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:NOTCH2
gene id: 9685:NOTCH2
uniprot id: A0A2I2U0T9
uniprot id: A0A2I2UD82
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9685:LPAR6
gene id: 9685:LPAR6
uniprot id: A0A5F5XLZ8
uniprot id: G9JVS7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:LOC105261319
gene id: 9685:LOC105261319
uniprot id: A0A2I2UE10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:USH1G
gene id: 9685:USH1G
uniprot id: M3XG41
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9685:ERCC3
gene id: 9685:ERCC3
uniprot id: M3W6V7
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9685:SCGB1A1
gene id: 9685:SCGB1A1
uniprot id: M3WAC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9685:ANP32A
gene id: 9685:ANP32A
uniprot id: A0A2I2UW24
names: Similarity
messages: Belongs to the ANP32 family.

9685:UTP14A
gene id: 9685:UTP14A
uniprot id: A0A337S6L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9685:FBN2
gene id: 9685:FBN2
uniprot id: M3WBW4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9685:ALX1
gene id: 9685:ALX1
uniprot id: A0A2I2UIK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9685:CTSK
gene id: 9685:CTSK
uniprot id: M3W0Q2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Cell membrane
messages: Lysosome
messages: Secreted

9685:EFNB1
gene id: 9685:EFNB1
uniprot id: M3WR70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:TFF2
gene id: 9685:TFF2
uniprot id: B4X8D8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:NEDD9
gene id: 9685:NEDD9
uniprot id: A0A2I2U357
uniprot id: A0A5F5Y5Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9685:KIFC1
gene id: 9685:KIFC1
uniprot id: M3WJ86
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:SNX17
gene id: 9685:SNX17
uniprot id: A0A337SPJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9685:HIKESHI
gene id: 9685:HIKESHI
uniprot id: A0A5F5XMB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9685:LOC101100878
gene id: 9685:LOC101100878
uniprot id: A0A2I2ULL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SYNPR
gene id: 9685:SYNPR
uniprot id: A0A2I2UCM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9685:SAMHD1
gene id: 9685:SAMHD1
uniprot id: M3WHZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9685:PLA2G4D
gene id: 9685:PLA2G4D
uniprot id: A0A2I2U0T3
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9685:CHST11
gene id: 9685:CHST11
uniprot id: A0A5F5XJQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:INHA
gene id: 9685:INHA
uniprot id: M3W6A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9685:GLYR1
gene id: 9685:GLYR1
uniprot id: A0A2I2UAE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

9685:SNX1
gene id: 9685:SNX1
uniprot id: M3W1Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9685:LTV1
gene id: 9685:LTV1
uniprot id: M3W9U2
names: Similarity
messages: Belongs to the LTV1 family.

9685:RGS3
gene id: 9685:RGS3
uniprot id: M3WX81
names: Subcellular Location Annotation
messages: Cytoplasm

9685:WT1
gene id: 9685:WT1
uniprot id: A0A337S500
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

9685:UROS
gene id: 9685:UROS
uniprot id: A0A5F5Y1J7
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9685:RAB3C
gene id: 9685:RAB3C
uniprot id: A0A2I2U435
uniprot id: A0A2I2V5I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9685:RNF20
gene id: 9685:RNF20
uniprot id: M3VWL4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9685:MRPL1
gene id: 9685:MRPL1
uniprot id: M3WJG1
names: Subcellular Location Annotation
messages: Mitochondrion

9685:SPG21
gene id: 9685:SPG21
uniprot id: M3WF48
names: Function
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9685:DOK4
gene id: 9685:DOK4
uniprot id: M3W2N6
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9685:SYVN1
gene id: 9685:SYVN1
uniprot id: A0A337S6X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRD1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:CAPN6
gene id: 9685:CAPN6
uniprot id: M3WF83
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:AMELX
gene id: 9685:AMELX
uniprot id: A0A2I2UAW9
uniprot id: M3X6K3
names: Similarity
messages: Belongs to the amelogenin family.

9685:SLC66A1
gene id: 9685:SLC66A1
uniprot id: M3WA77
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101087152
gene id: 9685:LOC101087152
uniprot id: A0A5F5XHY9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:NSUN4
gene id: 9685:NSUN4
uniprot id: A0A337RW22
uniprot id: A0A5F5Y272
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9685:FMO3
gene id: 9685:FMO3
uniprot id: M3VZK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Microsome membrane

9685:LOC101086441
gene id: 9685:LOC101086441
uniprot id: M3W9K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9685:PAX5
gene id: 9685:PAX5
uniprot id: M3VX00
names: Subcellular Location Annotation
messages: Nucleus

9685:AP1S1
gene id: 9685:AP1S1
uniprot id: A0A2I2UW94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9685:CANX
gene id: 9685:CANX
uniprot id: M3XBV5
names: Similarity
messages: Belongs to the calreticulin family.

9685:KRT18
gene id: 9685:KRT18
uniprot id: M3VUH3
names: Similarity
messages: Belongs to the intermediate filament family.

9685:CHMP1A
gene id: 9685:CHMP1A
uniprot id: M3XFV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9685:GATC
gene id: 9685:GATC
uniprot id: A0A2I2U0Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9685:CA11
gene id: 9685:CA11
uniprot id: A0A2I2U026
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9685:CDC42EP2
gene id: 9685:CDC42EP2
uniprot id: M3VWM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9685:LOC101086984
gene id: 9685:LOC101086984
uniprot id: A0A5F5Y553
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:ACSL1
gene id: 9685:ACSL1
uniprot id: M3W3F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9685:PPFIA2
gene id: 9685:PPFIA2
uniprot id: A0A2I2U896
uniprot id: A0A2I2UGL8
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9685:LOC101100916
gene id: 9685:LOC101100916
uniprot id: M3WZH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LIN54
gene id: 9685:LIN54
uniprot id: A0A337SNM8
uniprot id: M3WPK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9685:FYTTD1
gene id: 9685:FYTTD1
uniprot id: M3WCI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

9685:LOC101091742
gene id: 9685:LOC101091742
uniprot id: M3WJE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:NKRF
gene id: 9685:NKRF
uniprot id: M3WA55
names: Similarity
messages: Belongs to the CARF family.

9685:VPS35
gene id: 9685:VPS35
uniprot id: M3VWJ8
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9685:MFGE8
gene id: 9685:MFGE8
uniprot id: A0A5F5XE10
uniprot id: M3W678
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:TM9SF4
gene id: 9685:TM9SF4
uniprot id: A0A2I2UPX5
uniprot id: A0A5F5XIC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9685:DYNC1I1
gene id: 9685:DYNC1I1
uniprot id: A0A5F5XI80
uniprot id: M3WFT0
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9685:GIMAP2
gene id: 9685:GIMAP2
uniprot id: A0A2I2U8K3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9685:PLA2G2F
gene id: 9685:PLA2G2F
uniprot id: A0A2I2UWG3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9685:CELA1
gene id: 9685:CELA1
uniprot id: Q5R1M5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts upon elastin.
messages: Belongs to the peptidase S1 family. Elastase subfamily.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9685:CNGA4
gene id: 9685:CNGA4
uniprot id: M3X858
names: Subcellular Location Annotation
messages: Membrane

9685:SERINC1
gene id: 9685:SERINC1
uniprot id: M3X6Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9685:ANXA2
gene id: 9685:ANXA2
uniprot id: A0A337SCD2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
messages: Membrane
messages: basement membrane

9685:KAT5
gene id: 9685:KAT5
uniprot id: A0A2I2U9A3
uniprot id: M3VTZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9685:LOC101095034
gene id: 9685:LOC101095034
uniprot id: M3XG82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:NAPG
gene id: 9685:NAPG
uniprot id: M3X184
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9685:MED31
gene id: 9685:MED31
uniprot id: M3XD94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9685:TCN2
gene id: 9685:TCN2
uniprot id: M3W1K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9685:CNOT9
gene id: 9685:CNOT9
uniprot id: A0A2I2UUX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9685:CPPED1
gene id: 9685:CPPED1
uniprot id: M3WUY1
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9685:GPM6B
gene id: 9685:GPM6B
uniprot id: A0A2I2UJQ5
uniprot id: A0A2I2UVD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9685:ARHGDIB
gene id: 9685:ARHGDIB
uniprot id: A0A2I2UL98
names: Similarity
messages: Belongs to the Rho GDI family.

9685:RPS6KA3
gene id: 9685:RPS6KA3
uniprot id: A0A2I2U9Z1
uniprot id: A0A2I2UXB7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9685:TSG101
gene id: 9685:TSG101
uniprot id: A0A337SU32
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

9685:MPC2
gene id: 9685:MPC2
uniprot id: A0A337RX71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9685:SNUPN
gene id: 9685:SNUPN
uniprot id: A0A2I2U2N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

9685:TCTA
gene id: 9685:TCTA
uniprot id: M3WUV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9685:CNTNAP4
gene id: 9685:CNTNAP4
uniprot id: A0A337SUP5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:LOC105261153
gene id: 9685:LOC105261153
uniprot id: M3WDH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9685:USP16
gene id: 9685:USP16
uniprot id: A0A2I2UIC6
uniprot id: M3WJC9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9685:RPL10
gene id: 9685:RPL10
uniprot id: M3WF14
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9685:SLC25A39
gene id: 9685:SLC25A39
uniprot id: A0A2I2UC92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9685:FAM102B
gene id: 9685:FAM102B
uniprot id: M3X7D8
names: Similarity
messages: Belongs to the FAM102 family.

9685:SPO11
gene id: 9685:SPO11
uniprot id: M3VUQ4
names: Similarity
messages: Belongs to the TOP6A family.

9685:EGFR
gene id: 9685:EGFR
uniprot id: M3WMN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9685:ARMCX3
gene id: 9685:ARMCX3
uniprot id: M3X964
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9685:DNAAF6
gene id: 9685:DNAAF6
uniprot id: M3WVM8
names: Similarity
messages: Belongs to the PIH1 family.

9685:EIF5A2
gene id: 9685:EIF5A2
uniprot id: M3W8Z1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

9685:ALDH1A2
gene id: 9685:ALDH1A2
uniprot id: A0A2I2URL8
uniprot id: A0A337SBU2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9685:SPECC1L
gene id: 9685:SPECC1L
uniprot id: M3WWD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9685:LOC101097294
gene id: 9685:LOC101097294
uniprot id: M3X9B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:EMC10
gene id: 9685:EMC10
uniprot id: M3VUJ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC10 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9685:MYL5
gene id: 9685:MYL5
uniprot id: P41691
names: Miscellaneous
names: Subunit
names: Tissue Specificity
messages: Jaw-closing muscles.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: This chain binds calcium.

9685:MRPL15
gene id: 9685:MRPL15
uniprot id: A0A2I2UNR9
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9685:SLC25A42
gene id: 9685:SLC25A42
uniprot id: M3WC31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:TMEM265
gene id: 9685:TMEM265
uniprot id: A0A2I2UG28
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9685:MRPS27
gene id: 9685:MRPS27
uniprot id: M3W429
names: Subcellular Location Annotation
messages: Mitochondrion

9685:TSHB
gene id: 9685:TSHB
uniprot id: Q52R90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Indispensable for the control of thyroid structure and metabolism.
messages: Secreted

9685:B3GALT9
gene id: 9685:B3GALT9
uniprot id: M3XCM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:FAM25A
gene id: 9685:FAM25A
uniprot id: A0A5F5XXR4
names: Similarity
messages: Belongs to the FAM25 family.

9685:LOC101095773
gene id: 9685:LOC101095773
uniprot id: M3WRN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9685:HNRNPH2
gene id: 9685:HNRNPH2
uniprot id: M3WMI8
names: Subcellular Location Annotation
messages: nucleoplasm

9685:CZIB
gene id: 9685:CZIB
uniprot id: M3XEK6
names: Similarity
messages: Belongs to the UPF0587 family.

9685:GATA1
gene id: 9685:GATA1
uniprot id: M3WE57
names: Subcellular Location Annotation
messages: Nucleus

9685:TMEM131
gene id: 9685:TMEM131
uniprot id: A0A2I2UK82
names: Similarity
messages: Belongs to the TMEM131 family.

9685:PSMA1
gene id: 9685:PSMA1
uniprot id: M3WF05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9685:LOC101094818
gene id: 9685:LOC101094818
uniprot id: M3X5N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TMEM50A
gene id: 9685:TMEM50A
uniprot id: M3WHL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9685:FEZ1
gene id: 9685:FEZ1
uniprot id: M3WVR5
names: Similarity
messages: Belongs to the zygin family.

9685:AK5
gene id: 9685:AK5
uniprot id: A0A5F5XGD2
uniprot id: M3VWK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9685:LOC101098824
gene id: 9685:LOC101098824
uniprot id: M3XAB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GRPR
gene id: 9685:GRPR
uniprot id: A0A2I2UJT8
uniprot id: M3VX65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:DHX9
gene id: 9685:DHX9
uniprot id: A0A337SGK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9685:ASIC4
gene id: 9685:ASIC4
uniprot id: M3W6A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9685:IL18R1
gene id: 9685:IL18R1
uniprot id: Q6YBY1
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9685:PSMC5
gene id: 9685:PSMC5
uniprot id: M3W0G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9685:BMP4
gene id: 9685:BMP4
uniprot id: M3W2U0
names: Similarity
messages: Belongs to the TGF-beta family.

9685:GAD1
gene id: 9685:GAD1
uniprot id: P14748
names: Function
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
messages: Homodimer.

9685:LOC101083205
gene id: 9685:LOC101083205
uniprot id: M3WT72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CCHCR1
gene id: 9685:CCHCR1
uniprot id: M3WNJ0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9685:PRPF4
gene id: 9685:PRPF4
uniprot id: M3W473
names: Subcellular Location Annotation
messages: Nucleus speckle

9685:IL11RA
gene id: 9685:IL11RA
uniprot id: A0A2I2V0P2
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9685:CFL2
gene id: 9685:CFL2
uniprot id: M3W9N7
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9685:FAM120C
gene id: 9685:FAM120C
uniprot id: M3WR67
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9685:TLR9
gene id: 9685:TLR9
uniprot id: Q5I2M7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).
messages: Lysosome
messages: Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (By similarity). Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with SMPDL3B (By similarity).
messages: phagosome

9685:ZRANB2
gene id: 9685:ZRANB2
uniprot id: A0A337SAN9
uniprot id: M3WWN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9685:FELCATV1R15
gene id: 9685:FELCATV1R15
uniprot id: A0A0A0Y7K9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:NDUFA7
gene id: 9685:NDUFA7
uniprot id: M3WM64
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9685:EDC4
gene id: 9685:EDC4
uniprot id: M3WHR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9685:BAIAP2
gene id: 9685:BAIAP2
uniprot id: A0A2I2V0L4
uniprot id: A0A337S118
uniprot id: M3WF54
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9685:LOC101083287
gene id: 9685:LOC101083287
uniprot id: M3X1C9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:BABAM2
gene id: 9685:BABAM2
uniprot id: A0A337STG7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9685:SMIM15
gene id: 9685:SMIM15
uniprot id: M3X2G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9685:LOC101091896
gene id: 9685:LOC101091896
uniprot id: M3WWF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:APOA5
gene id: 9685:APOA5
uniprot id: A0A337S8I7
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9685:LOC101086560
gene id: 9685:LOC101086560
uniprot id: M3WYS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:NIPSNAP3A
gene id: 9685:NIPSNAP3A
uniprot id: A0A2I2UV88
names: Similarity
messages: Belongs to the NipSnap family.

9685:ZP3
gene id: 9685:ZP3
uniprot id: P48832
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Expressed in oocytes.
messages: N-glycosylated.
messages: O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.
messages: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. Interacts with ZP1 and ZP2.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9685:LOC101093772
gene id: 9685:LOC101093772
uniprot id: A0A337SW00
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:UTS2
gene id: 9685:UTS2
uniprot id: A0A5F5Y2K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9685:ECRG4
gene id: 9685:ECRG4
uniprot id: M3XBP1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9685:DBX1
gene id: 9685:DBX1
uniprot id: M3XFV2
names: Subcellular Location Annotation
messages: Nucleus

9685:F2
gene id: 9685:F2
uniprot id: M3WSI8
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

9685:SNRPD2
gene id: 9685:SNRPD2
uniprot id: M3X0Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

9685:SCN1A
gene id: 9685:SCN1A
uniprot id: A0A2I2UDI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9685:STC1
gene id: 9685:STC1
uniprot id: A0A5F5Y3A1
uniprot id: M3WZL9
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9685:CDH6
gene id: 9685:CDH6
uniprot id: M3VUL6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9685:OLFML3
gene id: 9685:OLFML3
uniprot id: M3WB23
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:ACRBP
gene id: 9685:ACRBP
uniprot id: M3W6N5
names: Subcellular Location Annotation
messages: acrosome

9685:PHF5A
gene id: 9685:PHF5A
uniprot id: M3W0S1
names: Similarity
messages: Belongs to the PHF5 family.

9685:PLK4
gene id: 9685:PLK4
uniprot id: A0A337SPE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cleavage furrow
messages: centriole

9685:RPL9
gene id: 9685:RPL9
uniprot id: M3WGN1
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

9685:MORF4L2
gene id: 9685:MORF4L2
uniprot id: A0A5F5XUU8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
messages: Nucleus

9685:TMEM9B
gene id: 9685:TMEM9B
uniprot id: A0A2I2U282
names: Similarity
messages: Belongs to the TMEM9 family.

9685:HAUS1
gene id: 9685:HAUS1
uniprot id: M3W0V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9685:SMIM12
gene id: 9685:SMIM12
uniprot id: M3XDT1
names: Similarity
messages: Belongs to the SMIM12 family.

9685:PNMT
gene id: 9685:PNMT
uniprot id: M3WCC0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9685:SF3B3
gene id: 9685:SF3B3
uniprot id: M3WBJ5
names: Subcellular Location Annotation
messages: Nucleus

9685:COPS3
gene id: 9685:COPS3
uniprot id: M3X663
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN3 family.
messages: Cytoplasm
messages: Nucleus

9685:MYO1C
gene id: 9685:MYO1C
uniprot id: A0A2I2V4A5
uniprot id: M3W5M2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9685:FELCATV1R1
gene id: 9685:FELCATV1R1
uniprot id: M3WS89
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:ARL2
gene id: 9685:ARL2
uniprot id: A0A2I2UTU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9685:MCHR1
gene id: 9685:MCHR1
uniprot id: M3WML9
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

9685:GCDH
gene id: 9685:GCDH
uniprot id: M3VUU6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9685:AMZ2
gene id: 9685:AMZ2
uniprot id: M3WP90
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9685:GAS8
gene id: 9685:GAS8
uniprot id: A0A5F5XV85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum axoneme

9685:LOC101096116
gene id: 9685:LOC101096116
uniprot id: M3VWL0
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9685:LOC101093450
gene id: 9685:LOC101093450
uniprot id: M3WVG4
names: Similarity
messages: Belongs to the CLCR family.

9685:CDH13
gene id: 9685:CDH13
uniprot id: M3W235
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Membrane

9685:PLAT
gene id: 9685:PLAT
uniprot id: A0A2I2UP76
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:GSTM3
gene id: 9685:GSTM3
uniprot id: M3WMX0
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9685:MTM1
gene id: 9685:MTM1
uniprot id: M3X251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

9685:MED19
gene id: 9685:MED19
uniprot id: A0A2I2U3W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9685:PGF
gene id: 9685:PGF
uniprot id: A0A2I2UEE8
uniprot id: A0A337S6B9
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9685:FCGR3A
gene id: 9685:FCGR3A
uniprot id: Q9N2I5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms a heterooligomeric complex with ITAM-containing signaling subunits FCER1G. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG.
messages: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity). Fc-binding subunit that associates with FCER1G adapter to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821).

9685:ROM1
gene id: 9685:ROM1
uniprot id: M3WAC9
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9685:DYNC1LI2
gene id: 9685:DYNC1LI2
uniprot id: M3WVF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9685:AP4B1
gene id: 9685:AP4B1
uniprot id: A0A2I2UUU9
uniprot id: A0A2I2V1N6
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9685:IK
gene id: 9685:IK
uniprot id: M3VWC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9685:CYBB
gene id: 9685:CYBB
uniprot id: M3VZS9
names: Subcellular Location Annotation
messages: Membrane

9685:PLD4
gene id: 9685:PLD4
uniprot id: M3WEG9
names: Similarity
messages: Belongs to the phospholipase D family.

9685:TSPAN18
gene id: 9685:TSPAN18
uniprot id: M3W1Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:STEAP4
gene id: 9685:STEAP4
uniprot id: M3XEC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9685:JAKMIP2
gene id: 9685:JAKMIP2
uniprot id: A0A2I2U0R5
uniprot id: A0A337SDW4
uniprot id: M3WP74
names: Similarity
messages: Belongs to the JAKMIP family.

9685:LOC101094572
gene id: 9685:LOC101094572
uniprot id: M3X1H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:SLC35A2
gene id: 9685:SLC35A2
uniprot id: M3VYR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9685:LSM3
gene id: 9685:LSM3
uniprot id: A0A2I2US81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9685:LOC101098931
gene id: 9685:LOC101098931
uniprot id: M3WSR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MAP2K1
gene id: 9685:MAP2K1
uniprot id: M3X621
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:TPX2
gene id: 9685:TPX2
uniprot id: A0A2I2UW03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

9685:SCNM1
gene id: 9685:SCNM1
uniprot id: M3W498
names: Function
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
messages: nucleoplasm

9685:MAX
gene id: 9685:MAX
uniprot id: P61245
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAX family.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity (By similarity).
messages: Nucleus
messages: Phosphorylated.
messages: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity (By similarity). Represses MYC transcriptional activity from E-box elements (By similarity).
messages: dendrite

9685:NEDD8
gene id: 9685:NEDD8
uniprot id: M3W4C3
names: Similarity
messages: Belongs to the ubiquitin family.

9685:CNOT8
gene id: 9685:CNOT8
uniprot id: M3VV25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9685:B3GALT1
gene id: 9685:B3GALT1
uniprot id: M3X7S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:ABI2
gene id: 9685:ABI2
uniprot id: A0A2I2V3N8
uniprot id: A0A337S1B2
uniprot id: A0A337SDU6
uniprot id: A0A5F5XUX5
uniprot id: A0A5F5Y6F1
uniprot id: M3WHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9685:ZSCAN22
gene id: 9685:ZSCAN22
uniprot id: M3WU60
names: Subcellular Location Annotation
messages: Nucleus

9685:STMN1
gene id: 9685:STMN1
uniprot id: M3WVG9
names: Similarity
messages: Belongs to the stathmin family.

9685:LOC101092789
gene id: 9685:LOC101092789
uniprot id: M3WTK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:BRCA1
gene id: 9685:BRCA1
uniprot id: M3WIB0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.
messages: Nucleus

9685:LOC101081980
gene id: 9685:LOC101081980
uniprot id: M3WXH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PTCD2
gene id: 9685:PTCD2
uniprot id: A0A337RYJ8
uniprot id: A0A5F5Y7D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

9685:FABP1
gene id: 9685:FABP1
uniprot id: M3WR74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9685:ASPN
gene id: 9685:ASPN
uniprot id: M3WWN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9685:CYP11B1
gene id: 9685:CYP11B1
uniprot id: A0A337SVG1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9685:LOC101100439
gene id: 9685:LOC101100439
uniprot id: M3XBF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TIMM8A
gene id: 9685:TIMM8A
uniprot id: M3X1J7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9685:ST3GAL2
gene id: 9685:ST3GAL2
uniprot id: M3WZY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9685:LOC101090590
gene id: 9685:LOC101090590
uniprot id: M3XB84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9685:AP1G1
gene id: 9685:AP1G1
uniprot id: A0A337S743
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9685:GJD2
gene id: 9685:GJD2
uniprot id: A0A2I2UYA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:LOC101091397
gene id: 9685:LOC101091397
uniprot id: M3WEA8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PRF1
gene id: 9685:PRF1
uniprot id: A0A2I2UKT0
uniprot id: A7LLU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9685:ADAM10
gene id: 9685:ADAM10
uniprot id: A0A2I2UWI1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: adherens junction

9685:YWHAQ
gene id: 9685:YWHAQ
uniprot id: M3W8I2
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
messages: Belongs to the 14-3-3 family.

9685:GATB
gene id: 9685:GATB
uniprot id: A0A5F5XNJ7
uniprot id: M3VZX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9685:LOC101088734
gene id: 9685:LOC101088734
uniprot id: A0A2I2UUB6
names: Similarity
messages: Belongs to the MHC class II family.

9685:SELENOS
gene id: 9685:SELENOS
uniprot id: M3X9I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
messages: Membrane

9685:SUSD6
gene id: 9685:SUSD6
uniprot id: A0A2I2ULS7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:SOX14
gene id: 9685:SOX14
uniprot id: A0A2I2U9L9
names: Subcellular Location Annotation
messages: Nucleus

9685:RPA3
gene id: 9685:RPA3
uniprot id: A0A2I2UN78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9685:CPNE9
gene id: 9685:CPNE9
uniprot id: M3WP11
names: Similarity
messages: Belongs to the copine family.

9685:IL15
gene id: 9685:IL15
uniprot id: M3WQ79
uniprot id: O97687
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).
messages: Secreted

9685:CCL16
gene id: 9685:CCL16
uniprot id: M3WCI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:ABL1
gene id: 9685:ABL1
uniprot id: M3W3H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9685:LOC101091873
gene id: 9685:LOC101091873
uniprot id: M3X3A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

9685:CHAF1B
gene id: 9685:CHAF1B
uniprot id: M3VZF6
names: Subcellular Location Annotation
messages: Nucleus

9685:DKK3
gene id: 9685:DKK3
uniprot id: A0A1E1FFM2
names: Similarity
messages: Belongs to the dickkopf family.

9685:HDHD2
gene id: 9685:HDHD2
uniprot id: M3VZ53
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9685:CCNDBP1
gene id: 9685:CCNDBP1
uniprot id: A0A2I2U7U6
uniprot id: A0A5F5Y5Y0
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

9685:WDR46
gene id: 9685:WDR46
uniprot id: M3W1E4
names: Subcellular Location Annotation
messages: nucleolus

9685:ADAM9
gene id: 9685:ADAM9
uniprot id: M3VYT3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:ING2
gene id: 9685:ING2
uniprot id: M3WYK9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9685:RIC8B
gene id: 9685:RIC8B
uniprot id: A0A2I2U4E2
uniprot id: A0A337S3E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9685:LOC101093951
gene id: 9685:LOC101093951
uniprot id: M3XC39
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9685:VIPAS39
gene id: 9685:VIPAS39
uniprot id: A0A5F5Y0Q2
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9685:HSD17B4
gene id: 9685:HSD17B4
uniprot id: M3W9K8
names: Subcellular Location Annotation
messages: Peroxisome

9685:LOC101090262
gene id: 9685:LOC101090262
uniprot id: M3X6T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:SYT1
gene id: 9685:SYT1
uniprot id: A0A337STW9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

9685:TPT1
gene id: 9685:TPT1
uniprot id: M3VXX1
names: Similarity
messages: Belongs to the TCTP family.

9685:SERPINC1
gene id: 9685:SERPINC1
uniprot id: M3WLL8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9685:LSM1
gene id: 9685:LSM1
uniprot id: A0A2I2V3Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9685:PUS3
gene id: 9685:PUS3
uniprot id: M3W3W9
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9685:ATP13A3
gene id: 9685:ATP13A3
uniprot id: A0A2I2UGJ7
uniprot id: A0A2I2UUY0
uniprot id: M3WB80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9685:FGA
gene id: 9685:FGA
uniprot id: M3W022
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9685:LOC101080959
gene id: 9685:LOC101080959
uniprot id: M3X958
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:KIF22
gene id: 9685:KIF22
uniprot id: M3WK55
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:IL5
gene id: 9685:IL5
uniprot id: O77515
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).
messages: Secreted

9685:AREG
gene id: 9685:AREG
uniprot id: M3VUM2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:MTIF3
gene id: 9685:MTIF3
uniprot id: M3W6V3
names: Similarity
messages: Belongs to the IF-3 family.

9685:CNN2
gene id: 9685:CNN2
uniprot id: A0A2I2V051
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9685:RCAN3
gene id: 9685:RCAN3
uniprot id: A0A337STC2
uniprot id: A0A5F5Y106
names: Similarity
messages: Belongs to the RCAN family.

9685:SLC25A40
gene id: 9685:SLC25A40
uniprot id: A0A2I2UE31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9685:PMM1
gene id: 9685:PMM1
uniprot id: A0A2I2UX50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9685:PTPRN
gene id: 9685:PTPRN
uniprot id: M3WER6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9685:SND1
gene id: 9685:SND1
uniprot id: M3W9B3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9685:HAUS3
gene id: 9685:HAUS3
uniprot id: M3WWN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9685:E2F7
gene id: 9685:E2F7
uniprot id: M3WDV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9685:RALB
gene id: 9685:RALB
uniprot id: M3WYA0
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9685:APLP2
gene id: 9685:APLP2
uniprot id: A0A2I2UM58
uniprot id: A0A337S8K3
uniprot id: M3WBJ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:CXCL16
gene id: 9685:CXCL16
uniprot id: M3WSR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Membrane

9685:ADTRP
gene id: 9685:ADTRP
uniprot id: M3WAX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9685:GGT1
gene id: 9685:GGT1
uniprot id: M3VWS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9685:LOC101101398
gene id: 9685:LOC101101398
uniprot id: M3WQN3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PHPT1
gene id: 9685:PHPT1
uniprot id: M3X816
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the janus family.
messages: Cytoplasm
messages: Exhibits phosphohistidine phosphatase activity.
messages: Monomer.

9685:EPYC
gene id: 9685:EPYC
uniprot id: M3XF62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: extracellular matrix

9685:RGS7BP
gene id: 9685:RGS7BP
uniprot id: A0A2I2UVK5
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9685:YPEL5
gene id: 9685:YPEL5
uniprot id: M3WRV9
names: Similarity
messages: Belongs to the yippee family.

9685:SOAT2
gene id: 9685:SOAT2
uniprot id: M3VUI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:HSPA4L
gene id: 9685:HSPA4L
uniprot id: M3W9Y3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9685:UBA52
gene id: 9685:UBA52
uniprot id: P63052
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.
messages: Nucleus
messages: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.
messages: Ribosomal protein L40 is part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).
messages: Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

9685:CPLX3
gene id: 9685:CPLX3
uniprot id: A0A5F5XQN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9685:GPRC5B
gene id: 9685:GPRC5B
uniprot id: A0A2I2UB41
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:NDRG4
gene id: 9685:NDRG4
uniprot id: A0A2I2U6L6
uniprot id: M3W665
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: cytosol

9685:CBS
gene id: 9685:CBS
uniprot id: M3W1B1
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

9685:TEKT3
gene id: 9685:TEKT3
uniprot id: A0A2I2UI14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9685:MPEG1
gene id: 9685:MPEG1
uniprot id: M3WGU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9685:CDK5
gene id: 9685:CDK5
uniprot id: M3X3E1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:TNNT2
gene id: 9685:TNNT2
uniprot id: A0A337SQ49
uniprot id: Q8HYJ0
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9685:AQP9
gene id: 9685:AQP9
uniprot id: M3XBC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9685:SEC23A
gene id: 9685:SEC23A
uniprot id: M3WPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9685:CYP1A1
gene id: 9685:CYP1A1
uniprot id: Q5KQT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).
messages: Belongs to the cytochrome P450 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. Interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.
messages: Microsome membrane
messages: Mitochondrion inner membrane

9685:CPQ
gene id: 9685:CPQ
uniprot id: A0A5F5XP07
uniprot id: A0A5F5Y2I4
uniprot id: A0A5F5Y5W4
uniprot id: M3WQN1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. The monomeric form is inactive while the homodimer is active.
messages: Lysosome
messages: Secreted

9685:TGM1
gene id: 9685:TGM1
uniprot id: M3W4C6
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9685:ACADVL
gene id: 9685:ACADVL
uniprot id: A0A337SL36
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9685:SYT17
gene id: 9685:SYT17
uniprot id: A0A2I2UM18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9685:CTSW
gene id: 9685:CTSW
uniprot id: A0A2I2U1T6
uniprot id: A0A5F5XF82
uniprot id: Q9TST1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Endoplasmic reticulum
messages: May have a specific function in the mechanism or regulation of T-cell cytolytic activity.

9685:TLX2
gene id: 9685:TLX2
uniprot id: A0A2I2V0H0
names: Subcellular Location Annotation
messages: Nucleus

9685:P4HA1
gene id: 9685:P4HA1
uniprot id: A0A2I2U3Y8
uniprot id: A0A2I2UQ94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9685:ESCO2
gene id: 9685:ESCO2
uniprot id: M3WKP5
names: Subcellular Location Annotation
messages: Nucleus

9685:ETFRF1
gene id: 9685:ETFRF1
uniprot id: A0A2I2UPJ5
names: Similarity
messages: Belongs to the complex I LYR family.

9685:CB3H15orf65
gene id: 9685:CB3H15orf65
uniprot id: A0A2I2UMS5
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9685:PIH1D1
gene id: 9685:PIH1D1
uniprot id: M3WAY6
names: Similarity
messages: Belongs to the PIH1 family.

9685:NDFIP2
gene id: 9685:NDFIP2
uniprot id: M3WXI8
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9685:PRPH
gene id: 9685:PRPH
uniprot id: M3WLA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon

9685:MFN1
gene id: 9685:MFN1
uniprot id: A0A2I2U8C5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9685:TSC22D1
gene id: 9685:TSC22D1
uniprot id: A0A2I2UVA2
uniprot id: M3WUL4
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9685:MARCHF4
gene id: 9685:MARCHF4
uniprot id: M3W0E6
names: Subcellular Location Annotation
messages: Membrane

9685:SNX2
gene id: 9685:SNX2
uniprot id: A0A2I2UUC7
uniprot id: M3WP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9685:SPG7
gene id: 9685:SPG7
uniprot id: M3W058
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9685:RTN4IP1
gene id: 9685:RTN4IP1
uniprot id: M3X977
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9685:AP3B1
gene id: 9685:AP3B1
uniprot id: M3X1N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9685:TRPM8
gene id: 9685:TRPM8
uniprot id: A0A5F5Y5X4
names: Subcellular Location Annotation
messages: Membrane

9685:AHCYL1
gene id: 9685:AHCYL1
uniprot id: M3W3K3
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9685:MRPS18A
gene id: 9685:MRPS18A
uniprot id: A0A2I2UT60
names: Subcellular Location Annotation
messages: Mitochondrion

9685:ACSL6
gene id: 9685:ACSL6
uniprot id: M3X4S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9685:CHRDL1
gene id: 9685:CHRDL1
uniprot id: A0A337SXT7
names: Subcellular Location Annotation
messages: Secreted

9685:GOT1L1
gene id: 9685:GOT1L1
uniprot id: M3WMT6
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

9685:FOXJ3
gene id: 9685:FOXJ3
uniprot id: A0A2I2UU10
names: Subcellular Location Annotation
messages: Nucleus

9685:CALHM1
gene id: 9685:CALHM1
uniprot id: M3VYF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9685:HNMT
gene id: 9685:HNMT
uniprot id: M3WWQ6
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9685:PADI1
gene id: 9685:PADI1
uniprot id: M3WCU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9685:SLC25A35
gene id: 9685:SLC25A35
uniprot id: M3VX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:GLRA2
gene id: 9685:GLRA2
uniprot id: A0A2I2UMS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9685:ACKR3
gene id: 9685:ACKR3
uniprot id: M3WH59
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:ABHD1
gene id: 9685:ABHD1
uniprot id: M3W3J8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9685:LOC102901287
gene id: 9685:LOC102901287
uniprot id: A0A5F5XHI2
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101082424
gene id: 9685:LOC101082424
uniprot id: A0A2I2V250
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9685:PABPC4
gene id: 9685:PABPC4
uniprot id: A0A2I2UUL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9685:FELCATV1R16
gene id: 9685:FELCATV1R16
uniprot id: M3WW21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:TIGD4
gene id: 9685:TIGD4
uniprot id: M3WPY0
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101098400
gene id: 9685:LOC101098400
uniprot id: M3WWZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GJB2
gene id: 9685:GJB2
uniprot id: A0A2I2V1B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:ZCCHC8
gene id: 9685:ZCCHC8
uniprot id: M3WV88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

9685:PTP4A3
gene id: 9685:PTP4A3
uniprot id: A0A2I2UKX7
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9685:TAFA2
gene id: 9685:TAFA2
uniprot id: A0A2I2UWB7
names: Similarity
messages: Belongs to the TAFA family.

9685:ALDH9A1
gene id: 9685:ALDH9A1
uniprot id: M3W1Z4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9685:TREX2
gene id: 9685:TREX2
uniprot id: M3WNU8
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9685:PSMB4
gene id: 9685:PSMB4
uniprot id: M3VXE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9685:FNIP1
gene id: 9685:FNIP1
uniprot id: A0A337S3G6
uniprot id: M3X2R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9685:XPC
gene id: 9685:XPC
uniprot id: A0A5F5XT13
uniprot id: M3VXF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

9685:LOC101100942
gene id: 9685:LOC101100942
uniprot id: A0A5F5XE18
uniprot id: A0A5F5XW06
uniprot id: A0A5F5XXI4
uniprot id: A0A5F5Y3K8
uniprot id: M3XEE6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9685:CCNT2
gene id: 9685:CCNT2
uniprot id: A0A2I2UN43
uniprot id: A0A5F5XNL6
uniprot id: M3W1A0
names: Similarity
messages: Belongs to the cyclin family.

9685:SPTBN2
gene id: 9685:SPTBN2
uniprot id: A0A2I2U9P4
names: Similarity
messages: Belongs to the spectrin family.

9685:HOXC6
gene id: 9685:HOXC6
uniprot id: A0A2I2UX54
names: Subcellular Location Annotation
messages: Nucleus

9685:STOML2
gene id: 9685:STOML2
uniprot id: A0A2I2ULA7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9685:TXLNA
gene id: 9685:TXLNA
uniprot id: M3WW86
names: Similarity
messages: Belongs to the taxilin family.

9685:PSMB1
gene id: 9685:PSMB1
uniprot id: M3X6T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9685:GSTCD
gene id: 9685:GSTCD
uniprot id: M3WWR6
names: Similarity
messages: Belongs to the GSTCD family.

9685:COX17
gene id: 9685:COX17
uniprot id: M3W591
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9685:HSDL2
gene id: 9685:HSDL2
uniprot id: M3WKK8
names: Subcellular Location Annotation
messages: Peroxisome

9685:AAR2
gene id: 9685:AAR2
uniprot id: A0A2I2UGH2
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9685:ERF
gene id: 9685:ERF
uniprot id: M3X163
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:RNASEH1
gene id: 9685:RNASEH1
uniprot id: M3WVC8
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9685:ZFYVE9
gene id: 9685:ZFYVE9
uniprot id: A0A2I2U5L6
uniprot id: M3XFS0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9685:SLC25A5
gene id: 9685:SLC25A5
uniprot id: M3VW78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9685:NFIL3
gene id: 9685:NFIL3
uniprot id: M3WIX7
names: Similarity
messages: Belongs to the bZIP family. NFIL3 subfamily.

9685:FUT11
gene id: 9685:FUT11
uniprot id: A0A2I2UM36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9685:LOC101083761
gene id: 9685:LOC101083761
uniprot id: M3WPB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101098084
gene id: 9685:LOC101098084
uniprot id: A0A2I2UX81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101085206
gene id: 9685:LOC101085206
uniprot id: M3X700
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:LHFPL6
gene id: 9685:LHFPL6
uniprot id: A0A2I2V2K2
names: Subcellular Location Annotation
messages: Membrane

9685:AMIGO3
gene id: 9685:AMIGO3
uniprot id: M3WDP8
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9685:CA2
gene id: 9685:CA2
uniprot id: M3W3J4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9685:KDELR3
gene id: 9685:KDELR3
uniprot id: M3VZ68
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:SKA2
gene id: 9685:SKA2
uniprot id: M3X2R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

9685:LOC101081111
gene id: 9685:LOC101081111
uniprot id: M3X731
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PRLR
gene id: 9685:PRLR
uniprot id: A0A2I2U3Q9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9685:EMP1
gene id: 9685:EMP1
uniprot id: A0A2I2UYU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9685:RXRG
gene id: 9685:RXRG
uniprot id: M3WDW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9685:SMDT1
gene id: 9685:SMDT1
uniprot id: M3VVL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9685:LOC101100165
gene id: 9685:LOC101100165
uniprot id: M3W7M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ARL5A
gene id: 9685:ARL5A
uniprot id: M3WL92
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9685:TMEM147
gene id: 9685:TMEM147
uniprot id: M3W5T0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:STX6
gene id: 9685:STX6
uniprot id: M3WFX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9685:LOC101082491
gene id: 9685:LOC101082491
uniprot id: M3WSM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:PACSIN1
gene id: 9685:PACSIN1
uniprot id: M3WMG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9685:SNX11
gene id: 9685:SNX11
uniprot id: M3WBA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9685:MON2
gene id: 9685:MON2
uniprot id: A0A337S7J0
names: Similarity
messages: Belongs to the MON2 family.

9685:LOC101099822
gene id: 9685:LOC101099822
uniprot id: M3X544
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9685:TOM1
gene id: 9685:TOM1
uniprot id: A0A2I2UP45
names: Similarity
messages: Belongs to the TOM1 family.

9685:ST8SIA1
gene id: 9685:ST8SIA1
uniprot id: A0A2I2V0G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9685:LOC101081204
gene id: 9685:LOC101081204
uniprot id: A0A2I2UKL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9685:GPR89A
gene id: 9685:GPR89A
uniprot id: A0A5F5XCN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9685:CIAO2B
gene id: 9685:CIAO2B
uniprot id: M3WPZ0
names: Similarity
messages: Belongs to the MIP18 family.

9685:IYD
gene id: 9685:IYD
uniprot id: A0A337SF28
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasmic vesicle membrane

9685:UBE2A
gene id: 9685:UBE2A
uniprot id: M3WS15
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9685:ELP3
gene id: 9685:ELP3
uniprot id: M3X6K4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9685:TRIT1
gene id: 9685:TRIT1
uniprot id: A0A2I2UZ49
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9685:B3GAT2
gene id: 9685:B3GAT2
uniprot id: A0A337SNA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:INHBA
gene id: 9685:INHBA
uniprot id: Q6X2S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B Interacts with FST and FSTL3 (By similarity).
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity).
messages: Secreted

9685:ADGRG3
gene id: 9685:ADGRG3
uniprot id: M3W8B0
names: Subcellular Location Annotation
messages: Membrane

9685:ROR2
gene id: 9685:ROR2
uniprot id: A0A5F5XV24
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:CASQ2
gene id: 9685:CASQ2
uniprot id: M3XE43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9685:CTNND1
gene id: 9685:CTNND1
uniprot id: A0A337S7Q5
names: Similarity
messages: Belongs to the beta-catenin family.

9685:LOC101085921
gene id: 9685:LOC101085921
uniprot id: M3WWA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9685:SLC12A6
gene id: 9685:SLC12A6
uniprot id: A0A2I2U7J3
uniprot id: A0A2I2UF14
uniprot id: M3VX68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9685:LHX9
gene id: 9685:LHX9
uniprot id: M3VXC0
names: Subcellular Location Annotation
messages: Nucleus

9685:ORC3
gene id: 9685:ORC3
uniprot id: M3W8W0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

9685:GABRB3
gene id: 9685:GABRB3
uniprot id: A0A337SUQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:RPL30
gene id: 9685:RPL30
uniprot id: M3VY11
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9685:GGACT
gene id: 9685:GGACT
uniprot id: M3WQ38
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9685:STAM2
gene id: 9685:STAM2
uniprot id: M3WQ89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9685:SLC35F6
gene id: 9685:SLC35F6
uniprot id: M3XFJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9685:RPS11
gene id: 9685:RPS11
uniprot id: M3WAZ1
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9685:RAB14
gene id: 9685:RAB14
uniprot id: M3WTD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9685:UBR2
gene id: 9685:UBR2
uniprot id: M3X4Z3
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9685:INKA1
gene id: 9685:INKA1
uniprot id: M3WDQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9685:LOC101095929
gene id: 9685:LOC101095929
uniprot id: A0A2I2UD68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MACIR
gene id: 9685:MACIR
uniprot id: M3WD62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9685:CRYBA4
gene id: 9685:CRYBA4
uniprot id: M3WDS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9685:NIPSNAP1
gene id: 9685:NIPSNAP1
uniprot id: M3W1U8
names: Similarity
messages: Belongs to the NipSnap family.

9685:LOC101100254
gene id: 9685:LOC101100254
uniprot id: M3XFT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101098487
gene id: 9685:LOC101098487
uniprot id: M3WJE3
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9685:LECT2
gene id: 9685:LECT2
uniprot id: M3WKX0
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9685:MYT1
gene id: 9685:MYT1
uniprot id: M3VW61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9685:FBP2
gene id: 9685:FBP2
uniprot id: M3VXP7
names: Similarity
messages: Belongs to the FBPase class 1 family.

9685:LZTFL1
gene id: 9685:LZTFL1
uniprot id: M3W6J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9685:UTP23
gene id: 9685:UTP23
uniprot id: A0A2I2UIZ8
names: Subcellular Location Annotation
messages: nucleolus

9685:RPL37A
gene id: 9685:RPL37A
uniprot id: A0A2I2UCL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9685:SCG3
gene id: 9685:SCG3
uniprot id: M3WH66
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: secretory vesicle membrane

9685:CNOT6L
gene id: 9685:CNOT6L
uniprot id: M3W9D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9685:CLTA
gene id: 9685:CLTA
uniprot id: A0A2I2UG69
uniprot id: A0A2I2V3L5
uniprot id: A0A5F5XT91
uniprot id: A0A5F5XUC1
uniprot id: M3WHJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9685:OAS2
gene id: 9685:OAS2
uniprot id: M3VUJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9685:LOC101096635
gene id: 9685:LOC101096635
uniprot id: M3X4A2
names: Subcellular Location Annotation
messages: Membrane

9685:ST6GALNAC4
gene id: 9685:ST6GALNAC4
uniprot id: M3X2S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9685:HNRNPA3
gene id: 9685:HNRNPA3
uniprot id: M3WGE6
names: Subcellular Location Annotation
messages: Nucleus

9685:CKS1B
gene id: 9685:CKS1B
uniprot id: A0A2I2U3K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9685:AGPAT4
gene id: 9685:AGPAT4
uniprot id: M3VUL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9685:LOC101083543
gene id: 9685:LOC101083543
uniprot id: M3WCM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MAPRE2
gene id: 9685:MAPRE2
uniprot id: A0A2I2UNL9
uniprot id: A0A337SIM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
messages: cytoskeleton

9685:CYSLTR2
gene id: 9685:CYSLTR2
uniprot id: A0A5F5Y2B7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:POLR3F
gene id: 9685:POLR3F
uniprot id: A0A2I2V008
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9685:DYNLT5
gene id: 9685:DYNLT5
uniprot id: A0A2I2UPC0
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9685:PPP6C
gene id: 9685:PPP6C
uniprot id: A0A2I2U7E3
names: Similarity
messages: Belongs to the PPP phosphatase family.

9685:ACTL6A
gene id: 9685:ACTL6A
uniprot id: M3WGS8
names: Similarity
messages: Belongs to the actin family.

9685:PPM1K
gene id: 9685:PPM1K
uniprot id: A0A2I2UN26
names: Similarity
messages: Belongs to the PP2C family.

9685:USP20
gene id: 9685:USP20
uniprot id: A0A2I2UAA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9685:REN
gene id: 9685:REN
uniprot id: M3VZC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted

9685:CAD
gene id: 9685:CAD
uniprot id: A0A2I2U188
uniprot id: A0A2I2UTI8
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

9685:OASL
gene id: 9685:OASL
uniprot id: M3WBT8
names: Similarity
messages: Belongs to the 2-5A synthase family.

9685:CEP57L1
gene id: 9685:CEP57L1
uniprot id: A0A337S6V5
names: Similarity
messages: Belongs to the translokin family.

9685:MAT2A
gene id: 9685:MAT2A
uniprot id: M3WG37
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9685:NTN4
gene id: 9685:NTN4
uniprot id: A0A337S1P0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:KCNA2
gene id: 9685:KCNA2
uniprot id: A0A5F5XTT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

9685:LOC101097169
gene id: 9685:LOC101097169
uniprot id: M3WSC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RPS8
gene id: 9685:RPS8
uniprot id: M3XE20
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9685:GRB10
gene id: 9685:GRB10
uniprot id: M3WGL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9685:C5AR1
gene id: 9685:C5AR1
uniprot id: A0A337S525
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:DLG1
gene id: 9685:DLG1
uniprot id: A0A2I2UPF7
uniprot id: A0A2I2UWT1
uniprot id: A0A337SAJ6
uniprot id: A0A337SSR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane

9685:WFIKKN2
gene id: 9685:WFIKKN2
uniprot id: M3X0C4
names: Similarity
messages: Belongs to the WFIKKN family.

9685:GRAMD1C
gene id: 9685:GRAMD1C
uniprot id: M3WWM4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:TNFRSF11B
gene id: 9685:TNFRSF11B
uniprot id: M3VXG1
names: Caution
names: Function
names: Subunit
messages: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:NBR1
gene id: 9685:NBR1
uniprot id: A0A2I2UFK8
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9685:UBA5
gene id: 9685:UBA5
uniprot id: M3XFJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9685:JAK2
gene id: 9685:JAK2
uniprot id: A0A337SI69
uniprot id: M3XFX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Endomembrane system
messages: Nucleus

9685:HOXD12
gene id: 9685:HOXD12
uniprot id: A0A2I2UDB5
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101084480
gene id: 9685:LOC101084480
uniprot id: M3WEW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RPA2
gene id: 9685:RPA2
uniprot id: A0A2I2UEQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 2 family.
messages: Nucleus

9685:CCDC22
gene id: 9685:CCDC22
uniprot id: M3WTR7
names: Similarity
messages: Belongs to the CCDC22 family.

9685:FAM102A
gene id: 9685:FAM102A
uniprot id: M3VWR8
names: Similarity
messages: Belongs to the FAM102 family.

9685:LRRC7
gene id: 9685:LRRC7
uniprot id: A0A5F5XDW9
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9685:PSMD2
gene id: 9685:PSMD2
uniprot id: M3W8D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9685:ELAVL4
gene id: 9685:ELAVL4
uniprot id: A0A337S8V2
uniprot id: A0A337SLZ5
uniprot id: A0A337SQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9685:CCNG2
gene id: 9685:CCNG2
uniprot id: M3X0F9
names: Similarity
messages: Belongs to the cyclin family.

9685:NAF1
gene id: 9685:NAF1
uniprot id: M3XCR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

9685:TOE1
gene id: 9685:TOE1
uniprot id: A0A2I2URP1
names: Similarity
messages: Belongs to the CAF1 family.

9685:MAP2K3
gene id: 9685:MAP2K3
uniprot id: M3WZ01
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:FZD3
gene id: 9685:FZD3
uniprot id: M3X5H1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:SAP30L
gene id: 9685:SAP30L
uniprot id: A0A337S290
names: Similarity
messages: Belongs to the SAP30 family.

9685:F9
gene id: 9685:F9
uniprot id: Q6SA95
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by factor XIa, which excises the activation peptide. The propeptide can also be removed by snake venom protease.
messages: Belongs to the peptidase S1 family.
messages: Calcium binds to the gamma-carboxyglutamic acid (Gla) residues in the Gla domain. Calcium can also bind, with stronger affinity, to another site beyond the Gla domain. Under physiological ion concentrations, Ca(2+) is displaced by Mg(2+) from some of the gammaglutamate residues in the N-terminal Gla domain. This leads to a subtle conformation change that may affect the interaction with its binding protein.
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Heterodimer of a light chain and a heavy chain; disulfide-linked. Interacts with SERPINC1.
messages: Predominantly O-glucosylated at Ser-99 by POGLUT1 in vitro.
messages: Secreted
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

9685:PRKACB
gene id: 9685:PRKACB
uniprot id: A0A337S3I6
uniprot id: M3X610
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9685:RPS3
gene id: 9685:RPS3
uniprot id: M3WG22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: nucleolus
messages: spindle

9685:TPH2
gene id: 9685:TPH2
uniprot id: M3W5F9
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9685:DYNLRB2
gene id: 9685:DYNLRB2
uniprot id: M3W1J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9685:HEXIM1
gene id: 9685:HEXIM1
uniprot id: M3W448
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9685:BRS3
gene id: 9685:BRS3
uniprot id: M3X3W7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9685:TLE1
gene id: 9685:TLE1
uniprot id: A0A2I2UIJ2
uniprot id: A0A337SUZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9685:PLPPR1
gene id: 9685:PLPPR1
uniprot id: M3VWK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

9685:TMEM47
gene id: 9685:TMEM47
uniprot id: M3X238
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9685:FMO4
gene id: 9685:FMO4
uniprot id: M3WH62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9685:ESRRA
gene id: 9685:ESRRA
uniprot id: A0A2I2U440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9685:LTB
gene id: 9685:LTB
uniprot id: A0A2I2UQ04
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9685:LOC101088423
gene id: 9685:LOC101088423
uniprot id: M3WSM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:HSD17B13
gene id: 9685:HSD17B13
uniprot id: A0A2I2UEH6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:DCPS
gene id: 9685:DCPS
uniprot id: A0A2I2UCB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9685:MYMK
gene id: 9685:MYMK
uniprot id: A0A2I2V1H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9685:BYSL
gene id: 9685:BYSL
uniprot id: M3WUE3
names: Similarity
messages: Belongs to the bystin family.

9685:TTC26
gene id: 9685:TTC26
uniprot id: A0A337S733
names: Similarity
messages: Belongs to the IFT56 family.

9685:OPN4
gene id: 9685:OPN4
uniprot id: Q5YKK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Cell membrane
messages: Eye. Expression is restricted within the ganglion cell layer.
messages: Perikaryon
messages: Photoreceptor that binds cis-retinaldehydes (By similarity). Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light (By similarity). May be involved in the optokinetic visual tracking response (By similarity). May be involved in the regulation of retinal hyaloid vessel growth and regression (By similarity).
messages: axon
messages: dendrite

9685:HSD17B11
gene id: 9685:HSD17B11
uniprot id: M3X4D0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:GBP5
gene id: 9685:GBP5
uniprot id: M3VVU6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9685:PARD3
gene id: 9685:PARD3
uniprot id: A0A5F5XJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

9685:ANKH
gene id: 9685:ANKH
uniprot id: M3WGL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9685:TMEM129
gene id: 9685:TMEM129
uniprot id: M3WRD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9685:YIF1A
gene id: 9685:YIF1A
uniprot id: M3WB69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9685:MCM6
gene id: 9685:MCM6
uniprot id: M3WJ49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9685:ALDH7A1
gene id: 9685:ALDH7A1
uniprot id: M3XAZ0
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

9685:RABGGTA
gene id: 9685:RABGGTA
uniprot id: M3W4C7
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9685:PDE6D
gene id: 9685:PDE6D
uniprot id: A0A2I2V1R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9685:RNASEH2A
gene id: 9685:RNASEH2A
uniprot id: M3VUU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9685:B4GALT2
gene id: 9685:B4GALT2
uniprot id: A0A337SM79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9685:C8A
gene id: 9685:C8A
uniprot id: M3W158
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:CLDN25
gene id: 9685:CLDN25
uniprot id: M3X7L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9685:POLG
gene id: 9685:POLG
uniprot id: M3WHT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

9685:PSMC3
gene id: 9685:PSMC3
uniprot id: A0A337SBG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9685:PDPK1
gene id: 9685:PDPK1
uniprot id: A0A337SBQ1
uniprot id: M3VXM6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

9685:RPL6
gene id: 9685:RPL6
uniprot id: M3W6M1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9685:SLC4A11
gene id: 9685:SLC4A11
uniprot id: A0A2I2U3A8
uniprot id: A0A5F5XL25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9685:LOC101097782
gene id: 9685:LOC101097782
uniprot id: A0A5F5XEY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9685:TNF
gene id: 9685:TNF
uniprot id: P19101
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9685:SUPT6H
gene id: 9685:SUPT6H
uniprot id: M3W1E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9685:ALAD
gene id: 9685:ALAD
uniprot id: M3WB25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

9685:HIGD1B
gene id: 9685:HIGD1B
uniprot id: M3W440
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9685:SDAD1
gene id: 9685:SDAD1
uniprot id: M3W9G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9685:PRPSAP2
gene id: 9685:PRPSAP2
uniprot id: A0A337S712
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9685:COX7A1
gene id: 9685:COX7A1
uniprot id: M3WK61
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9685:TMEM170A
gene id: 9685:TMEM170A
uniprot id: A0A337S8C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9685:ETFA
gene id: 9685:ETFA
uniprot id: M3W5A7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9685:RPS16
gene id: 9685:RPS16
uniprot id: M3WDU7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9685:PFKFB1
gene id: 9685:PFKFB1
uniprot id: A0A337S3U5
uniprot id: A0A337SUA4
uniprot id: M3VVL9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9685:CCDC65
gene id: 9685:CCDC65
uniprot id: A0A337SLJ8
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: flagellum axoneme

9685:TAC3
gene id: 9685:TAC3
uniprot id: M3WKX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9685:SAMD4B
gene id: 9685:SAMD4B
uniprot id: A0A2I2UPN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9685:LOC101093829
gene id: 9685:LOC101093829
uniprot id: M3X3S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ADIPOR2
gene id: 9685:ADIPOR2
uniprot id: M3XBK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9685:STAC
gene id: 9685:STAC
uniprot id: M3W3A8
names: Subcellular Location Annotation
messages: sarcolemma

9685:HYAL3
gene id: 9685:HYAL3
uniprot id: A0A337RZA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Membrane
messages: acrosome

9685:CCT3
gene id: 9685:CCT3
uniprot id: A0A2I2V532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9685:MINDY3
gene id: 9685:MINDY3
uniprot id: A0A337S3N9
uniprot id: M3WYA2
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9685:CES2
gene id: 9685:CES2
uniprot id: M3W105
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9685:LOC101099751
gene id: 9685:LOC101099751
uniprot id: M3WSB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:KCND1
gene id: 9685:KCND1
uniprot id: A0A5F5XJP8
uniprot id: M3VYS3
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9685:SPICE1
gene id: 9685:SPICE1
uniprot id: A0A2I2U3E8
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

9685:GPRC5A
gene id: 9685:GPRC5A
uniprot id: M3WJV7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:IMPG1
gene id: 9685:IMPG1
uniprot id: A0A5F5XXH0
uniprot id: M3WLK1
names: Subcellular Location Annotation
messages: interphotoreceptor matrix

9685:CDO1
gene id: 9685:CDO1
uniprot id: M3WPX5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9685:TRPM1
gene id: 9685:TRPM1
uniprot id: A0A2I2V3X7
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101101632
gene id: 9685:LOC101101632
uniprot id: A0A337S7Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PTGR2
gene id: 9685:PTGR2
uniprot id: M3WRI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9685:DHFR
gene id: 9685:DHFR
uniprot id: A0A337SMR3
uniprot id: M3X0Q6
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9685:GCNT2
gene id: 9685:GCNT2
uniprot id: M3X1R7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9685:STMN4
gene id: 9685:STMN4
uniprot id: A0A2I2U3I2
uniprot id: A0A2I2V3A0
uniprot id: M3WKN9
names: Similarity
messages: Belongs to the stathmin family.

9685:LOC101092885
gene id: 9685:LOC101092885
uniprot id: M3X1N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:NFU1
gene id: 9685:NFU1
uniprot id: M3X3Q1
names: Similarity
messages: Belongs to the NifU family.

9685:UTP3
gene id: 9685:UTP3
uniprot id: M3W7E7
names: Similarity
messages: Belongs to the SAS10 family.

9685:LOC101087349
gene id: 9685:LOC101087349
uniprot id: M3WY34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:YPEL1
gene id: 9685:YPEL1
uniprot id: A0A5F5Y2A1
names: Similarity
messages: Belongs to the yippee family.

9685:RRS1
gene id: 9685:RRS1
uniprot id: M3WKI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9685:CRYBB3
gene id: 9685:CRYBB3
uniprot id: M3WJG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9685:PSMA8
gene id: 9685:PSMA8
uniprot id: M3XET1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9685:RAB4B
gene id: 9685:RAB4B
uniprot id: M3WTP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9685:SNCA
gene id: 9685:SNCA
uniprot id: A0A2I2U480
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

9685:LOC101088358
gene id: 9685:LOC101088358
uniprot id: A0A5F5Y4J9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CD36
gene id: 9685:CD36
uniprot id: M3WZ55
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

9685:LIN52
gene id: 9685:LIN52
uniprot id: A0A337SHP8
names: Similarity
messages: Belongs to the lin-52 family.

9685:PIGF
gene id: 9685:PIGF
uniprot id: M3WMX8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:SPOP
gene id: 9685:SPOP
uniprot id: A0A5F5Y0L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9685:HSPA4
gene id: 9685:HSPA4
uniprot id: M3WGX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9685:ORC5
gene id: 9685:ORC5
uniprot id: M3WTS9
names: Subcellular Location Annotation
messages: Nucleus

9685:TOB1
gene id: 9685:TOB1
uniprot id: A0A5F5XD56
names: Similarity
messages: Belongs to the BTG family.

9685:PLK2
gene id: 9685:PLK2
uniprot id: M3WEE3
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9685:UBE4B
gene id: 9685:UBE4B
uniprot id: M3WKZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9685:TRPC7
gene id: 9685:TRPC7
uniprot id: M3WIH8
names: Subcellular Location Annotation
messages: Membrane

9685:STAT3
gene id: 9685:STAT3
uniprot id: M3VY01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9685:SI
gene id: 9685:SI
uniprot id: B1Q4L3
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:NRDE2
gene id: 9685:NRDE2
uniprot id: M3WEV8
names: Similarity
messages: Belongs to the NRDE2 family.

9685:BMT2
gene id: 9685:BMT2
uniprot id: M3WUQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9685:PARD6A
gene id: 9685:PARD6A
uniprot id: M3WB52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9685:MPP4
gene id: 9685:MPP4
uniprot id: A0A337ST83
uniprot id: M3W1D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9685:SMC4
gene id: 9685:SMC4
uniprot id: A0A2I2UAJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

9685:RNF168
gene id: 9685:RNF168
uniprot id: M3WSK4
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with UBE2N/UBC13.
messages: Nucleus
messages: Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
messages: Ubiquitinated.

9685:TRAPPC13
gene id: 9685:TRAPPC13
uniprot id: A0A337SBS2
uniprot id: M3WY00
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9685:LAMA3
gene id: 9685:LAMA3
uniprot id: A0A2I2UKX1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CD63
gene id: 9685:CD63
uniprot id: Q76B49
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity).
messages: Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1. Interacts with CD9. Identified in a complex with CD9 and ITGB3. Interacts with PMEL. Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes. Interacts with SYT7 (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro) (By similarity).
messages: extracellular exosome
messages: multivesicular body

9685:FSHR
gene id: 9685:FSHR
uniprot id: A0A2I2V553
uniprot id: Q5GJ04
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (By similarity).
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation.
messages: Membrane
messages: N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.
messages: Sulfated.

9685:ZKSCAN2
gene id: 9685:ZKSCAN2
uniprot id: M3WMA3
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9685:UFM1
gene id: 9685:UFM1
uniprot id: A0A2I2USD4
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9685:CACNG4
gene id: 9685:CACNG4
uniprot id: A0A2I2UA66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

9685:STK17B
gene id: 9685:STK17B
uniprot id: M3X7F7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:SMAD5
gene id: 9685:SMAD5
uniprot id: M3X9P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9685:ALDH18A1
gene id: 9685:ALDH18A1
uniprot id: M3VWL7
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9685:AP2M1
gene id: 9685:AP2M1
uniprot id: A0A337SCA3
uniprot id: M3W8D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9685:APOD
gene id: 9685:APOD
uniprot id: M3X8P7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.
messages: Secreted

9685:F11R
gene id: 9685:F11R
uniprot id: Q2WGK2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) In case of orthoreovirus infection, serves as receptor for the virus.
messages: (Microbial infection) Interacts with calicivirus capsid protein.
messages: (Microbial infection) Interacts with the orthoreovirus sigma-1 capsid protein.
messages: (Microbial infection) May act as a cellular receptor for calicivirus.
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with ITGAL (via I-domain).
messages: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation.
messages: The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.
messages: tight junction

9685:TRMT5
gene id: 9685:TRMT5
uniprot id: M3W6J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

9685:HARS2
gene id: 9685:HARS2
uniprot id: M3VWD4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9685:PLD1
gene id: 9685:PLD1
uniprot id: A0A2I2UFV0
uniprot id: A0A2I2UYK1
names: Similarity
messages: Belongs to the phospholipase D family.

9685:CKAP2
gene id: 9685:CKAP2
uniprot id: M3WCK0
names: Similarity
messages: Belongs to the CKAP2 family.

9685:TPD52
gene id: 9685:TPD52
uniprot id: A0A337SAU5
names: Similarity
messages: Belongs to the TPD52 family.

9685:SCAND1
gene id: 9685:SCAND1
uniprot id: A0A2I2U4S2
names: Subcellular Location Annotation
messages: Nucleus

9685:TMEM106A
gene id: 9685:TMEM106A
uniprot id: M3WIB2
names: Similarity
messages: Belongs to the TMEM106 family.

9685:LOC109498816
gene id: 9685:LOC109498816
uniprot id: A0A337SA79
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9685:LOC101090551
gene id: 9685:LOC101090551
uniprot id: A0A2I2UGB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.

9685:GLRA1
gene id: 9685:GLRA1
uniprot id: M3WNZ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

9685:CYP2W1
gene id: 9685:CYP2W1
uniprot id: A0A5F5XD23
names: Similarity
messages: Belongs to the cytochrome P450 family.

9685:IL18
gene id: 9685:IL18
uniprot id: A0A2I2U3U7
uniprot id: A2IRI7
uniprot id: Q95M33
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.

9685:SGPL1
gene id: 9685:SGPL1
uniprot id: M3XG91
names: Similarity
messages: Belongs to the group II decarboxylase family.

9685:DDR2
gene id: 9685:DDR2
uniprot id: A0A2I2UQI7
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101091265
gene id: 9685:LOC101091265
uniprot id: A0A5F5XTX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9685:TVP23A
gene id: 9685:TVP23A
uniprot id: M3WCB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9685:TTC4
gene id: 9685:TTC4
uniprot id: M3XBQ5
names: Similarity
messages: Belongs to the TTC4 family.

9685:DNMT3B
gene id: 9685:DNMT3B
uniprot id: A0A337SSV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9685:AGO1
gene id: 9685:AGO1
uniprot id: M3VVB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9685:GHRH
gene id: 9685:GHRH
uniprot id: M3W6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9685:CYP2E1
gene id: 9685:CYP2E1
uniprot id: Q5KR51
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9685:CA2H19orf25
gene id: 9685:CA2H19orf25
uniprot id: M3VX98
names: Similarity
messages: Belongs to the UPF0449 family.

9685:MIX23
gene id: 9685:MIX23
uniprot id: M3X245
names: Similarity
messages: Belongs to the MIX23 family.

9685:NPY5R
gene id: 9685:NPY5R
uniprot id: M3XA14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

9685:TSPAN33
gene id: 9685:TSPAN33
uniprot id: M3WKW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:TRIM32
gene id: 9685:TRIM32
uniprot id: K7ZMH7
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9685:TSPAN31
gene id: 9685:TSPAN31
uniprot id: M3WQH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:CALCR
gene id: 9685:CALCR
uniprot id: M3W7Q9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

9685:POSTN
gene id: 9685:POSTN
uniprot id: A0A2I2U312
uniprot id: A0A2I2U6U3
uniprot id: A0A2I2UGA8
uniprot id: A0A2I2UGL9
uniprot id: A0A337RY02
names: Subcellular Location Annotation
messages: extracellular matrix

9685:PC
gene id: 9685:PC
uniprot id: A0A2I2UTX2
uniprot id: M3W7N8
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

9685:ERBB3
gene id: 9685:ERBB3
uniprot id: M3WLH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9685:EIF4E2
gene id: 9685:EIF4E2
uniprot id: A0A2I2U9W7
uniprot id: A0A337S6M9
uniprot id: A0A337SJH0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9685:MMP27
gene id: 9685:MMP27
uniprot id: M3WN99
names: Similarity
messages: Belongs to the peptidase M10A family.

9685:CHMP2B
gene id: 9685:CHMP2B
uniprot id: M3WYZ6
names: Similarity
messages: Belongs to the SNF7 family.

9685:MRGPRX2
gene id: 9685:MRGPRX2
uniprot id: M3XBY5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:TMED3
gene id: 9685:TMED3
uniprot id: A0A337SAE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9685:PKNOX1
gene id: 9685:PKNOX1
uniprot id: A0A337SSN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9685:MRPS10
gene id: 9685:MRPS10
uniprot id: A0A337SE50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9685:HCRTR1
gene id: 9685:HCRTR1
uniprot id: A0A2I2U878
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:ZSCAN26
gene id: 9685:ZSCAN26
uniprot id: M3X7M7
names: Subcellular Location Annotation
messages: Nucleus

9685:BBS2
gene id: 9685:BBS2
uniprot id: M3WA02
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9685:KEF43 p11
gene id: 9685:KEF43_p11
uniprot id: P48888
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9685:NDUFA12
gene id: 9685:NDUFA12
uniprot id: M3WRN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9685:AMPD3
gene id: 9685:AMPD3
uniprot id: M3VUP4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9685:ACAP2
gene id: 9685:ACAP2
uniprot id: A0A2I2V1T1
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9685:SCO2
gene id: 9685:SCO2
uniprot id: M3WI34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

9685:RPL10A
gene id: 9685:RPL10A
uniprot id: M3WHU6
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9685:NCOA3
gene id: 9685:NCOA3
uniprot id: M3WLT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9685:VTI1B
gene id: 9685:VTI1B
uniprot id: M3WK20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9685:USP37
gene id: 9685:USP37
uniprot id: M3VYE7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9685:CD34
gene id: 9685:CD34
uniprot id: Q8HZ47
names: Subcellular Location Annotation
messages: Membrane

9685:MC5R
gene id: 9685:MC5R
uniprot id: M3VY79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

9685:SKP1
gene id: 9685:SKP1
uniprot id: A0A2I2UBL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

9685:DDO
gene id: 9685:DDO
uniprot id: M3VX19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9685:PSMB8
gene id: 9685:PSMB8
uniprot id: M3XF92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9685:TM4SF19
gene id: 9685:TM4SF19
uniprot id: M3W839
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9685:CGA
gene id: 9685:CGA
uniprot id: Q52R91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9685:CSGALNACT2
gene id: 9685:CSGALNACT2
uniprot id: M3WJU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9685:ABLIM3
gene id: 9685:ABLIM3
uniprot id: A0A337S4L1
names: Subcellular Location Annotation
messages: Cytoplasm

9685:KIFBP
gene id: 9685:KIFBP
uniprot id: A0A337SXN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

9685:PIGK
gene id: 9685:PIGK
uniprot id: M3X6D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

9685:CYP7A1
gene id: 9685:CYP7A1
uniprot id: M3W8S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9685:LOC101100898
gene id: 9685:LOC101100898
uniprot id: M3WRP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:HTATSF1
gene id: 9685:HTATSF1
uniprot id: M3XB09
names: Similarity
messages: Belongs to the HTATSF1 family.

9685:FGD3
gene id: 9685:FGD3
uniprot id: M3WM03
names: Subcellular Location Annotation
messages: cytoskeleton

9685:ANKRD13C
gene id: 9685:ANKRD13C
uniprot id: A0A2I2V5F3
uniprot id: A0A5F5Y301
names: Subcellular Location Annotation
messages: Membrane

9685:IL10
gene id: 9685:IL10
uniprot id: P55029
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-10 family.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
messages: Secreted

9685:PFDN1
gene id: 9685:PFDN1
uniprot id: M3VWC0
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9685:PIK3R1
gene id: 9685:PIK3R1
uniprot id: A0A337S1J0
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9685:ELOF1
gene id: 9685:ELOF1
uniprot id: M3W344
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9685:CHRM5
gene id: 9685:CHRM5
uniprot id: M3WUP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9685:DDA1
gene id: 9685:DDA1
uniprot id: M3VVT7
names: Similarity
messages: Belongs to the DDA1 family.

9685:TMCO3
gene id: 9685:TMCO3
uniprot id: M3WKD3
names: Subcellular Location Annotation
messages: Membrane

9685:ARMC8
gene id: 9685:ARMC8
uniprot id: A0A2I2UPD5
uniprot id: M3VXL8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9685:TNFSF15
gene id: 9685:TNFSF15
uniprot id: M3VU80
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9685:CCSER1
gene id: 9685:CCSER1
uniprot id: A0A2I2UE78
uniprot id: A0A5F5XGC6
names: Similarity
messages: Belongs to the CCSER family.

9685:LOC101091557
gene id: 9685:LOC101091557
uniprot id: A0A337SUV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GLRA4
gene id: 9685:GLRA4
uniprot id: M3WF44
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9685:ADRA1A
gene id: 9685:ADRA1A
uniprot id: A0A2I2U7I5
uniprot id: A0A2I2USK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9685:ATP6V0E1
gene id: 9685:ATP6V0E1
uniprot id: M3XBC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9685:INSIG2
gene id: 9685:INSIG2
uniprot id: A0A5F5XQY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9685:SUCNR1
gene id: 9685:SUCNR1
uniprot id: M3X921
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:MCP-1
gene id: 9685:MCP-1
uniprot id: M3VVI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:SPSB4
gene id: 9685:SPSB4
uniprot id: M3WXV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9685:LOC101090642
gene id: 9685:LOC101090642
uniprot id: M3X6F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PLCG2
gene id: 9685:PLCG2
uniprot id: M3W393
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9685:TMEM225B
gene id: 9685:TMEM225B
uniprot id: M3X2H5
names: Subcellular Location Annotation
messages: Membrane

9685:SLC25A45
gene id: 9685:SLC25A45
uniprot id: A0A2I2U0U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:PPP4R3A
gene id: 9685:PPP4R3A
uniprot id: M3WT68
names: Similarity
messages: Belongs to the SMEK family.

9685:GAPVD1
gene id: 9685:GAPVD1
uniprot id: A0A2I2UDN4
uniprot id: A0A337S6X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9685:SPIC
gene id: 9685:SPIC
uniprot id: A0A2I2UPH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:CPM
gene id: 9685:CPM
uniprot id: M3WKG9
names: Similarity
messages: Belongs to the peptidase M14 family.

9685:CRYAB
gene id: 9685:CRYAB
uniprot id: M3WT79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9685:NME7
gene id: 9685:NME7
uniprot id: M3WB88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9685:TSC22D3
gene id: 9685:TSC22D3
uniprot id: A0A337SGM8
uniprot id: A0A337SNR1
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9685:BORCS5
gene id: 9685:BORCS5
uniprot id: A0A2I2U384
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9685:FAM163A
gene id: 9685:FAM163A
uniprot id: M3X6B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9685:TMCC1
gene id: 9685:TMCC1
uniprot id: A0A2I2UQW8
names: Similarity
messages: Belongs to the TEX28 family.

9685:FRG1
gene id: 9685:FRG1
uniprot id: M3WRX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9685:LOC101081158
gene id: 9685:LOC101081158
uniprot id: A0A2I2U8E4
uniprot id: A0A5F5XSN2
names: Similarity
messages: Belongs to the multicopper oxidase family.

9685:HSD17B10
gene id: 9685:HSD17B10
uniprot id: M3WJP6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:LAPTM5
gene id: 9685:LAPTM5
uniprot id: M3XB38
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9685:SPATS2L
gene id: 9685:SPATS2L
uniprot id: A0A5F5XN43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

9685:TRHR
gene id: 9685:TRHR
uniprot id: M3WD44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9685:DCP2
gene id: 9685:DCP2
uniprot id: M3VXH4
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9685:SLC30A3
gene id: 9685:SLC30A3
uniprot id: M3WSD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9685:TSPAN32
gene id: 9685:TSPAN32
uniprot id: M3W6S7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:PDE1A
gene id: 9685:PDE1A
uniprot id: M3W3R7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9685:QKI
gene id: 9685:QKI
uniprot id: Q7JJZ8
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity).
messages: Methylated by PRMT1.
messages: Nucleus
messages: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
messages: The KH domain and the Qua2 region are involved in RNA binding.
messages: Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).

9685:PSMC6
gene id: 9685:PSMC6
uniprot id: M3WNQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9685:CAVIN2
gene id: 9685:CAVIN2
uniprot id: M3XCQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9685:PCK1
gene id: 9685:PCK1
uniprot id: M3VUQ7
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9685:VPS33B
gene id: 9685:VPS33B
uniprot id: A0A337SIS2
uniprot id: M3WG33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9685:LOC105260531
gene id: 9685:LOC105260531
uniprot id: A0A2I2UQQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:BCO1
gene id: 9685:BCO1
uniprot id: M3W391
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9685:SARM1
gene id: 9685:SARM1
uniprot id: M3W9I7
names: Similarity
messages: Belongs to the SARM1 family.

9685:GPR18
gene id: 9685:GPR18
uniprot id: M3X8S6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9685:DDX5
gene id: 9685:DDX5
uniprot id: M3W0H3
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9685:TRMT6
gene id: 9685:TRMT6
uniprot id: M3VZQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9685:MYOG
gene id: 9685:MYOG
uniprot id: A0A2I2U9I7
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101090836
gene id: 9685:LOC101090836
uniprot id: A0A337S0A9
names: Similarity
messages: Belongs to the BEX family.

9685:LOC101083875
gene id: 9685:LOC101083875
uniprot id: A0A2I2UT92
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9685:ADRA2B
gene id: 9685:ADRA2B
uniprot id: M3X1F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Membrane

9685:VPS41
gene id: 9685:VPS41
uniprot id: A0A2I2UFR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9685:USP33
gene id: 9685:USP33
uniprot id: M3WZ44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9685:KAT8
gene id: 9685:KAT8
uniprot id: M3VYT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9685:SMN2
gene id: 9685:SMN2
uniprot id: Q8HYB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMN family.
messages: Cajal body
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Homooligomer; may form higher order homooligomers in the dimer to octamer range. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Component of an import snRNP complex composed of KPNB1, RNUT1, SMN1 and ZNF259. Interacts with DDX20, FBL, NOLA1, RNUT1, SYNCRIP and with several spliceosomal snRNP core Sm proteins, including SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE and ILF3. Interacts with GEMIN2; the interaction is direct. Interacts with GEMIN3; the interaction is direct. Interacts with GEMIN8; the interaction is direct. Interacts with SNRPB; the interaction is direct. Interacts (via Tudor domain) with SNRPD1 (via C-terminus); the interaction is direct. Interacts with SNRPD2; the interaction is direct. Interacts (via Tudor domain) with SNRPD3 (via C-terminus); the interaction is direct. Interacts with SNRPE; the interaction is direct. Interacts with OSTF1, LSM10, LSM11 and RPP20/POP7. Interacts (via C-terminal region) with ZPR1 (via C-terminal region). Interacts (via Tudor domain) with COIL. Interacts with SETX; recruits SETX to POLR2A. Interacts with POLR2A (via the C-terminal domain (CTD)). Interacts with PRMT5. Interacts with XRN2. Interacts (via C-terminus) with FMR1 (via C-terminus); the interaction is direct and occurs in a RNA-independent manner. Interacts (via Tudor domain) with SF3B2 ('Arg-508'-methylated form). Interacts with WRAP53/TCAB1. Interacts (via Tudor domain) with ELAVL4 in an RNA-independent manner; the interaction is required for localization of ELAVL4 to RNA granules. Interacts with FRG1.
messages: Perikaryon
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
messages: The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins.
messages: Z line
messages: axon
messages: gem
messages: neuron projection

9685:GANAB
gene id: 9685:GANAB
uniprot id: M3WAD1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9685:LOC105260478
gene id: 9685:LOC105260478
uniprot id: A0A5F5XMT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9685:SYT14
gene id: 9685:SYT14
uniprot id: A0A337RY76
uniprot id: A0A337SJR0
names: Similarity
messages: Belongs to the synaptotagmin family.

9685:EID1
gene id: 9685:EID1
uniprot id: A0A5F5XFX2
names: Subcellular Location Annotation
messages: Nucleus

9685:EFNA1
gene id: 9685:EFNA1
uniprot id: M3X089
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:RPS23
gene id: 9685:RPS23
uniprot id: M3WAB5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9685:LMBR1L
gene id: 9685:LMBR1L
uniprot id: M3VU39
names: Similarity
messages: Belongs to the LIMR family.

9685:TRAPPC2
gene id: 9685:TRAPPC2
uniprot id: M3X8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9685:OTX2
gene id: 9685:OTX2
uniprot id: M3X072
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9685:LOC101080455
gene id: 9685:LOC101080455
uniprot id: A0A5F5XKU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:KCND2
gene id: 9685:KCND2
uniprot id: M3W8J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9685:STK32B
gene id: 9685:STK32B
uniprot id: A0A2I2UMV7
uniprot id: M3W1I6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:LOC101094311
gene id: 9685:LOC101094311
uniprot id: M3X4Y3
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9685:ATP5F1C
gene id: 9685:ATP5F1C
uniprot id: A0A337RXB3
uniprot id: M3VU98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9685:CF1H1orf74
gene id: 9685:CF1H1orf74
uniprot id: M3WM05
names: Similarity
messages: Belongs to the UPF0739 family.

9685:LOC101093987
gene id: 9685:LOC101093987
uniprot id: M3WUE8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GRPEL1
gene id: 9685:GRPEL1
uniprot id: M3X6X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9685:GPRIN3
gene id: 9685:GPRIN3
uniprot id: A0A5F5XF41
names: Function
messages: May be involved in neurite outgrowth.

9685:ARMT1
gene id: 9685:ARMT1
uniprot id: M3WCV6
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9685:COQ3
gene id: 9685:COQ3
uniprot id: M3WNZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9685:POU4F3
gene id: 9685:POU4F3
uniprot id: M3WWX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9685:SGCD
gene id: 9685:SGCD
uniprot id: M3WRZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9685:CEBPE
gene id: 9685:CEBPE
uniprot id: M3VYB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9685:CCNG1
gene id: 9685:CCNG1
uniprot id: M3WYN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

9685:LAMTOR1
gene id: 9685:LAMTOR1
uniprot id: M3W3V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9685:FTSJ3
gene id: 9685:FTSJ3
uniprot id: M3WJV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

9685:ST3GAL3
gene id: 9685:ST3GAL3
uniprot id: A0A2I2U8L2
uniprot id: M3W5Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9685:RGS8
gene id: 9685:RGS8
uniprot id: A0A337S906
uniprot id: M3W4U0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: Perikaryon
messages: dendrite

9685:REEP5
gene id: 9685:REEP5
uniprot id: M3WUT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9685:LOC101095127
gene id: 9685:LOC101095127
uniprot id: A0A5F5XLN4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:CALHM5
gene id: 9685:CALHM5
uniprot id: A0A2I2V0T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9685:CE2H16orf70
gene id: 9685:CE2H16orf70
uniprot id: M3WB35
names: Similarity
messages: Belongs to the PHAF1 family.

9685:NANOG
gene id: 9685:NANOG
uniprot id: D3U663
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101091367
gene id: 9685:LOC101091367
uniprot id: A0A5F5Y142
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC105260418
gene id: 9685:LOC105260418
uniprot id: A0A337SK14
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9685:PPARD
gene id: 9685:PPARD
uniprot id: A0A2I2U3X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9685:UNC13C
gene id: 9685:UNC13C
uniprot id: A0A337SUF1
names: Subcellular Location Annotation
messages: Cytoplasm

9685:IER3IP1
gene id: 9685:IER3IP1
uniprot id: A0A2I2USM4
names: Similarity
messages: Belongs to the YOS1 family.

9685:UBE4A
gene id: 9685:UBE4A
uniprot id: A0A5K1TTU0
names: Subcellular Location Annotation
messages: Cytoplasm

9685:ACSM5
gene id: 9685:ACSM5
uniprot id: M3W231
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9685:ABHD3
gene id: 9685:ABHD3
uniprot id: M3WQI0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9685:CDH15
gene id: 9685:CDH15
uniprot id: M3W1R7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9685:HK1
gene id: 9685:HK1
uniprot id: A0A2I2UHA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9685:MDGA1
gene id: 9685:MDGA1
uniprot id: M3W6F6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:GJB5
gene id: 9685:GJB5
uniprot id: M3WJZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:PHYHIPL
gene id: 9685:PHYHIPL
uniprot id: M3WRV0
names: Similarity
messages: Belongs to the PHYHIP family.

9685:STXBP5
gene id: 9685:STXBP5
uniprot id: M3WC49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9685:KPNA1
gene id: 9685:KPNA1
uniprot id: A0A337S696
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9685:SLC12A4
gene id: 9685:SLC12A4
uniprot id: A0A2I2UHF3
uniprot id: M3WHR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9685:SLC39A11
gene id: 9685:SLC39A11
uniprot id: A0A337RYN5
names: Subcellular Location Annotation
messages: Membrane

9685:ASB8
gene id: 9685:ASB8
uniprot id: A0A2I2UI44
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9685:OVOL1
gene id: 9685:OVOL1
uniprot id: M3W8L2
names: Subcellular Location Annotation
messages: Nucleus

9685:TIMM10
gene id: 9685:TIMM10
uniprot id: A0A2I2U515
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

9685:ZC3H12B
gene id: 9685:ZC3H12B
uniprot id: A0A2I2UF15
names: Similarity
messages: Belongs to the ZC3H12 family.

9685:CARMIL1
gene id: 9685:CARMIL1
uniprot id: A0A2I2UJZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9685:XRCC4
gene id: 9685:XRCC4
uniprot id: M3X1I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

9685:PMP2
gene id: 9685:PMP2
uniprot id: M3W3Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9685:GLO1
gene id: 9685:GLO1
uniprot id: M3X4B1
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9685:SH3BGRL
gene id: 9685:SH3BGRL
uniprot id: M3X5I6
names: Similarity
messages: Belongs to the SH3BGR family.

9685:JPT1
gene id: 9685:JPT1
uniprot id: M3WKU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9685:ZDHHC4
gene id: 9685:ZDHHC4
uniprot id: M3XCI9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:LOC101092190
gene id: 9685:LOC101092190
uniprot id: M3WX61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9685:POLR3K
gene id: 9685:POLR3K
uniprot id: A0A2I2U4L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9685:ARL8B
gene id: 9685:ARL8B
uniprot id: M3VVB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: spindle

9685:SLC46A2
gene id: 9685:SLC46A2
uniprot id: A0A5F5XFZ8
uniprot id: M3WTC9
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101092136
gene id: 9685:LOC101092136
uniprot id: M3X3N8
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9685:LOC101095096
gene id: 9685:LOC101095096
uniprot id: M3WJ28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9685:CPNE8
gene id: 9685:CPNE8
uniprot id: M3XCA2
names: Similarity
messages: Belongs to the copine family.

9685:SEC11A
gene id: 9685:SEC11A
uniprot id: A0A337S2H2
uniprot id: M3X3W0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:ABLIM1
gene id: 9685:ABLIM1
uniprot id: A0A2I2UAW4
names: Subcellular Location Annotation
messages: Cytoplasm

9685:SEC61A1
gene id: 9685:SEC61A1
uniprot id: A0A5F5XHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:SRP72
gene id: 9685:SRP72
uniprot id: M3X9Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

9685:IFGGE
gene id: 9685:IFGGE
uniprot id: J7PDP3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9685:SCN4A
gene id: 9685:SCN4A
uniprot id: M3W0G7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9685:FGF1
gene id: 9685:FGF1
uniprot id: A0A2I2U4K4
uniprot id: A0A337S8W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9685:CC2H3orf70
gene id: 9685:CC2H3orf70
uniprot id: A0A2I2UFT7
names: Similarity
messages: Belongs to the UPF0524 family.

9685:FAM174A
gene id: 9685:FAM174A
uniprot id: M3XFE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9685:ATP2A1
gene id: 9685:ATP2A1
uniprot id: A0A2I2U569
uniprot id: A0A2I2V2N1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9685:LOC101092602
gene id: 9685:LOC101092602
uniprot id: M3XCT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.

9685:HPS5
gene id: 9685:HPS5
uniprot id: M3WEL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9685:OGDH
gene id: 9685:OGDH
uniprot id: A0A337RVJ8
uniprot id: A0A337SRK5
uniprot id: A0A337SVV8
uniprot id: M3WCZ2
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9685:CRYGN
gene id: 9685:CRYGN
uniprot id: M3WII0
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9685:KIAA1191
gene id: 9685:KIAA1191
uniprot id: A0A2I2V0G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9685:TNFSF8
gene id: 9685:TNFSF8
uniprot id: A0A2I2UYN0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9685:MMP14
gene id: 9685:MMP14
uniprot id: M3W681
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Cytoplasm
messages: Melanosome

9685:TMED9
gene id: 9685:TMED9
uniprot id: A0A2I2UFI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:TMEM107
gene id: 9685:TMEM107
uniprot id: A0A2I2UH78
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101090648
gene id: 9685:LOC101090648
uniprot id: M3X150
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PPP1R15B
gene id: 9685:PPP1R15B
uniprot id: M3WUP7
names: Similarity
messages: Belongs to the PPP1R15 family.

9685:TNFRSF1A
gene id: 9685:TNFRSF1A
uniprot id: Q95ND3
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:RSPO4
gene id: 9685:RSPO4
uniprot id: M3WP14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9685:ART4
gene id: 9685:ART4
uniprot id: M3XDK8
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9685:CCNYL1
gene id: 9685:CCNYL1
uniprot id: A0A337SH46
uniprot id: M3WU07
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9685:TMEM11
gene id: 9685:TMEM11
uniprot id: A0A2I2U7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

9685:PPP1R12B
gene id: 9685:PPP1R12B
uniprot id: A0A337S3Q2
uniprot id: A0A5F5Y2T4
names: Subcellular Location Annotation
messages: stress fiber

9685:DMBX1
gene id: 9685:DMBX1
uniprot id: M3WFX7
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101089797
gene id: 9685:LOC101089797
uniprot id: M3VYH2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:THEMIS
gene id: 9685:THEMIS
uniprot id: M3WD74
names: Similarity
messages: Belongs to the themis family.

9685:RBM15
gene id: 9685:RBM15
uniprot id: M3XCA7
names: Similarity
messages: Belongs to the RRM Spen family.

9685:LOC101089263
gene id: 9685:LOC101089263
uniprot id: M3W6H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9685:ZUP1
gene id: 9685:ZUP1
uniprot id: M3XGC8
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9685:MFSD8
gene id: 9685:MFSD8
uniprot id: A0A337SPS8
names: Subcellular Location Annotation
messages: Membrane

9685:SMARCA1
gene id: 9685:SMARCA1
uniprot id: A0A337S5J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9685:USB1
gene id: 9685:USB1
uniprot id: M3VYZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9685:PDSS1
gene id: 9685:PDSS1
uniprot id: A0A5F5Y0T5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9685:UBAC2
gene id: 9685:UBAC2
uniprot id: M3WCW4
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101087880
gene id: 9685:LOC101087880
uniprot id: M3VX87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9685:ASPHD1
gene id: 9685:ASPHD1
uniprot id: M3WK67
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9685:PRDX2
gene id: 9685:PRDX2
uniprot id: M3VUU2
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9685:LOC101088781
gene id: 9685:LOC101088781
uniprot id: M3X4S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CPB2
gene id: 9685:CPB2
uniprot id: M3WAY1
names: Similarity
messages: Belongs to the peptidase M14 family.

9685:CHM
gene id: 9685:CHM
uniprot id: A0A5F5XSK1
uniprot id: M3X8J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9685:XRCC1
gene id: 9685:XRCC1
uniprot id: M3W3P2
names: Subcellular Location Annotation
messages: Nucleus

9685:DDX1
gene id: 9685:DDX1
uniprot id: A0A337SJN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule

9685:SESN1
gene id: 9685:SESN1
uniprot id: A0A337RYT7
uniprot id: M3X2C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9685:ORC6
gene id: 9685:ORC6
uniprot id: M3XG01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9685:SCO1
gene id: 9685:SCO1
uniprot id: M3WXX6
names: Similarity
messages: Belongs to the SCO1/2 family.

9685:ERGIC3
gene id: 9685:ERGIC3
uniprot id: A0A2I2UXM4
uniprot id: M3VZZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9685:TLR4
gene id: 9685:TLR4
uniprot id: P58727
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with TICAM2. Interacts with NOX4. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with MAP3K21; this interaction leads to negative regulation of TLR4 signaling. Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR6. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Interacts with TICAM1 in response to LPS in a WDFY1-dependent manner. Interacts with WDFY1 in response to LPS. Interacts with SMPDL3B. Interacts with CEACAM1; upon lipopolysaccharide stimulation, forms a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Interacts with RFTN1; the interaction occurs in response to lipopolysaccharide stimulation. Interacts with SCIMP; the interaction occurs in response to lipopolysaccharide stimulation and is enhanced by phosphorylation of SCIMP by LYN (By similarity). This interaction facilitates the phosphorylation of TLR4 by LYN which elicits a selective cytokine response in macrophages (By similarity). Interacts with TRAF3IP3 (By similarity). Interacts with TREM1; this interaction enhances TLR4-mediated inflammatory response (By similarity).
messages: Cell membrane
messages: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity). Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation (By similarity).
messages: Early endosome
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Phosphorylated on tyrosine residues by LYN after binding lipopolysaccharide.
messages: The TIR domain mediates interaction with NOX4.
messages: ruffle

9685:CD4H9orf64
gene id: 9685:CD4H9orf64
uniprot id: A0A2I2U1N7
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

9685:HENMT1
gene id: 9685:HENMT1
uniprot id: M3W191
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9685:HSPB2
gene id: 9685:HSPB2
uniprot id: A0A2I2UD88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.
messages: Nucleus

9685:CIAO3
gene id: 9685:CIAO3
uniprot id: M3W9D4
names: Similarity
messages: Belongs to the NARF family.

9685:POPDC2
gene id: 9685:POPDC2
uniprot id: A0A337SPI8
uniprot id: A0A5F5Y427
uniprot id: M3W590
names: Similarity
messages: Belongs to the popeye family.

9685:TMEM167B
gene id: 9685:TMEM167B
uniprot id: A0A2I2V282
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:FBXO32
gene id: 9685:FBXO32
uniprot id: M3WDB6
names: Subcellular Location Annotation
messages: Nucleus

9685:PPP2R5E
gene id: 9685:PPP2R5E
uniprot id: M3WK80
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9685:LHX4
gene id: 9685:LHX4
uniprot id: A0A2I2UPI3
names: Subcellular Location Annotation
messages: Nucleus

9685:SNX33
gene id: 9685:SNX33
uniprot id: M3WGW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9685:USP14
gene id: 9685:USP14
uniprot id: A0A5F5XQG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9685:VPS51
gene id: 9685:VPS51
uniprot id: M3W5J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Recycling endosome
messages: trans-Golgi network

9685:DEFB124
gene id: 9685:DEFB124
uniprot id: M3WL33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9685:ENPP6
gene id: 9685:ENPP6
uniprot id: M3VWW1
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

9685:TMX2
gene id: 9685:TMX2
uniprot id: M3WNB5
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9685:TIMM22
gene id: 9685:TIMM22
uniprot id: A0A2I2U2J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9685:LTC4S
gene id: 9685:LTC4S
uniprot id: M3WPR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:NPR2
gene id: 9685:NPR2
uniprot id: M3WHI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9685:PIGH
gene id: 9685:PIGH
uniprot id: A0A2I2USE5
names: Similarity
messages: Belongs to the PIGH family.

9685:TOP3A
gene id: 9685:TOP3A
uniprot id: A0A2I2UBY3
uniprot id: A0A5F5XQM6
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9685:NASP
gene id: 9685:NASP
uniprot id: A0A337S1D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9685:DNAL4
gene id: 9685:DNAL4
uniprot id: A0A337S529
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9685:CFAP91
gene id: 9685:CFAP91
uniprot id: M3W593
names: Similarity
messages: Belongs to the CFAP91 family.

9685:RNF146
gene id: 9685:RNF146
uniprot id: M3WM22
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9685:ZFP69
gene id: 9685:ZFP69
uniprot id: A0A2I2UVI9
names: Subcellular Location Annotation
messages: Nucleus

9685:ALDH2
gene id: 9685:ALDH2
uniprot id: M3X7B5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9685:EIF4A1
gene id: 9685:EIF4A1
uniprot id: M3XBC3
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9685:LOC101086734
gene id: 9685:LOC101086734
uniprot id: M3WTH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PKIA
gene id: 9685:PKIA
uniprot id: A0A2I2U9N8
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9685:GMFB
gene id: 9685:GMFB
uniprot id: A0A337S765
uniprot id: A0A5F5XD16
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9685:LOC101085956
gene id: 9685:LOC101085956
uniprot id: A0A2I2US12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TAF12
gene id: 9685:TAF12
uniprot id: M3WQ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9685:FAM91A1
gene id: 9685:FAM91A1
uniprot id: M3WDC0
names: Similarity
messages: Belongs to the FAM91 family.

9685:OXER1
gene id: 9685:OXER1
uniprot id: A0A5F5Y6U4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:PODXL
gene id: 9685:PODXL
uniprot id: A0A5F5XE19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the podocalyxin family.
messages: Cell membrane
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
messages: Membrane
messages: Membrane raft
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

9685:ATG16L2
gene id: 9685:ATG16L2
uniprot id: A0A5F5XZF4
uniprot id: M3WIE2
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9685:LOC101096930
gene id: 9685:LOC101096930
uniprot id: M3WXJ7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CHRNA7
gene id: 9685:CHRNA7
uniprot id: A0A337SQQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:TARDBP
gene id: 9685:TARDBP
uniprot id: A0A2I2U8C8
names: Subcellular Location Annotation
messages: Nucleus

9685:TM2D2
gene id: 9685:TM2D2
uniprot id: M3VYT0
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101082834
gene id: 9685:LOC101082834
uniprot id: M3WVG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101081818
gene id: 9685:LOC101081818
uniprot id: M3X984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PPP4R3B
gene id: 9685:PPP4R3B
uniprot id: M3X3M6
names: Similarity
messages: Belongs to the SMEK family.

9685:EEF1A1
gene id: 9685:EEF1A1
uniprot id: Q66RN5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1 and TXK. Interacts with KARS1. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner (By similarity). Interacts with PPP1R16B (By similarity). Interacts with SPHK1 and SPHK2; both interactions increase SPHK1 and SPHK2 kinase activity (By similarity).
messages: ISGylated.
messages: Nucleus
messages: Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.
messages: Trimethylated at Lys-79 by EEF1AKMT1. Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. Trimethylated at Lys-318 by EEF1AKMT2. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs. Trimethylated at Gly-2 by METTL13. Mono- and dimethylated at Lys-55 by METTL13; dimethylated form is predominant.
messages: nucleolus

9685:SNRPC
gene id: 9685:SNRPC
uniprot id: A0A337RWF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

9685:TMEM225
gene id: 9685:TMEM225
uniprot id: M3W3A1
names: Subcellular Location Annotation
messages: Membrane

9685:CPB1
gene id: 9685:CPB1
uniprot id: A0A2I2U0Y4
names: Similarity
messages: Belongs to the peptidase M14 family.

9685:PHKB
gene id: 9685:PHKB
uniprot id: A0A2I2URL9
uniprot id: A0A2I2UUF6
uniprot id: M3W9V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9685:IGF2BP3
gene id: 9685:IGF2BP3
uniprot id: M3WQM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule

9685:LOC101099074
gene id: 9685:LOC101099074
uniprot id: M3XAQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GPR137C
gene id: 9685:GPR137C
uniprot id: M3WDB0
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9685:CHMP5
gene id: 9685:CHMP5
uniprot id: M3X6F1
names: Similarity
messages: Belongs to the SNF7 family.

9685:MSX2
gene id: 9685:MSX2
uniprot id: A0A2I2UYT3
names: Subcellular Location Annotation
messages: Nucleus

9685:TMEM17
gene id: 9685:TMEM17
uniprot id: A0A2I2UTV3
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101082541
gene id: 9685:LOC101082541
uniprot id: M3WCP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TAFA5
gene id: 9685:TAFA5
uniprot id: A0A337SES7
names: Similarity
messages: Belongs to the TAFA family.

9685:GSDMC
gene id: 9685:GSDMC
uniprot id: M3W6U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9685:USP21
gene id: 9685:USP21
uniprot id: M3WC74
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9685:MMP16
gene id: 9685:MMP16
uniprot id: M3WTU5
names: Similarity
messages: Belongs to the peptidase M10A family.

9685:IL1RL2
gene id: 9685:IL1RL2
uniprot id: M3WXC8
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9685:ITGA3
gene id: 9685:ITGA3
uniprot id: A0A2I2USG0
uniprot id: M3W2E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9685:RAB18
gene id: 9685:RAB18
uniprot id: M3WSV9
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9685:ITGB3
gene id: 9685:ITGB3
uniprot id: A0A2I2ULN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9685:SLC35A5
gene id: 9685:SLC35A5
uniprot id: A0A5F5Y716
uniprot id: M3WWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9685:HOATZ
gene id: 9685:HOATZ
uniprot id: A0A337STH5
names: Similarity
messages: Belongs to the HOATZ family.

9685:WASF2
gene id: 9685:WASF2
uniprot id: M3W8J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9685:GUCY2F
gene id: 9685:GUCY2F
uniprot id: M3WAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9685:RPE65
gene id: 9685:RPE65
uniprot id: M3WH64
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9685:OCIAD1
gene id: 9685:OCIAD1
uniprot id: M3X1S5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9685:DAPK2
gene id: 9685:DAPK2
uniprot id: A0A2I2UQ18
uniprot id: M3W1Q1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:TRAPPC3
gene id: 9685:TRAPPC3
uniprot id: A0A337ST58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9685:CRYBB2
gene id: 9685:CRYBB2
uniprot id: M3WJG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9685:GLYCTK
gene id: 9685:GLYCTK
uniprot id: M3WN46
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9685:GNG11
gene id: 9685:GNG11
uniprot id: A0A2I2U3C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9685:PSMC4
gene id: 9685:PSMC4
uniprot id: M3VVV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9685:ACTN3
gene id: 9685:ACTN3
uniprot id: M3W478
names: Similarity
messages: Belongs to the alpha-actinin family.

9685:CEP57
gene id: 9685:CEP57
uniprot id: A0A337S784
names: Similarity
messages: Belongs to the translokin family.

9685:POLH
gene id: 9685:POLH
uniprot id: M3WC09
names: Subcellular Location Annotation
messages: Nucleus

9685:NDNF
gene id: 9685:NDNF
uniprot id: M3WEB4
names: Subcellular Location Annotation
messages: Secreted

9685:FIS1
gene id: 9685:FIS1
uniprot id: A0A337RU63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

9685:TAS2R38
gene id: 9685:TAS2R38
uniprot id: M3X5D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9685:TLR3
gene id: 9685:TLR3
uniprot id: A0ENH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9685:B3GAT3
gene id: 9685:B3GAT3
uniprot id: M3WAD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:DAD1
gene id: 9685:DAD1
uniprot id: M3X9E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9685:COG4
gene id: 9685:COG4
uniprot id: M3WBJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9685:LOC101101164
gene id: 9685:LOC101101164
uniprot id: M3WRL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CDC26
gene id: 9685:CDC26
uniprot id: M3W472
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9685:ERBB4
gene id: 9685:ERBB4
uniprot id: A0A337S8Z7
uniprot id: A0A337SET3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9685:SDR9C7
gene id: 9685:SDR9C7
uniprot id: A0A2I2UG01
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:PTS
gene id: 9685:PTS
uniprot id: M3XBA1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9685:NAA35
gene id: 9685:NAA35
uniprot id: A0A2I2V283
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9685:LOC102901316
gene id: 9685:LOC102901316
uniprot id: A0A2I2UMU4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9685:FAAH
gene id: 9685:FAAH
uniprot id: M3W0D6
names: Similarity
messages: Belongs to the amidase family.

9685:NFIA
gene id: 9685:NFIA
uniprot id: A0A2I2U3F1
uniprot id: A0A337SGT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9685:SYNGR4
gene id: 9685:SYNGR4
uniprot id: M3VVR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9685:DPYD
gene id: 9685:DPYD
uniprot id: A0A2I2UPM5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

9685:NR1D1
gene id: 9685:NR1D1
uniprot id: M3WLR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9685:QARS1
gene id: 9685:QARS1
uniprot id: A0A2I2UCN5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9685:SLC25A22
gene id: 9685:SLC25A22
uniprot id: M3W2X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:GABARAPL1
gene id: 9685:GABARAPL1
uniprot id: M3WXZ6
names: Similarity
messages: Belongs to the ATG8 family.

9685:GRAP
gene id: 9685:GRAP
uniprot id: M3WMK8
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

9685:CDH18
gene id: 9685:CDH18
uniprot id: M3WJ78
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9685:APMAP
gene id: 9685:APMAP
uniprot id: M3X681
names: Similarity
messages: Belongs to the strictosidine synthase family.

9685:KCNT2
gene id: 9685:KCNT2
uniprot id: A0A2I2USQ4
uniprot id: A0A2I2V2Y1
uniprot id: M3X8N9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:GTDC1
gene id: 9685:GTDC1
uniprot id: A0A2I2UNU9
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

9685:GPRASP2
gene id: 9685:GPRASP2
uniprot id: A0A5F5XT20
names: Similarity
messages: Belongs to the GPRASP family.

9685:LOC101082972
gene id: 9685:LOC101082972
uniprot id: A0A5F5XIN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ALG8
gene id: 9685:ALG8
uniprot id: M3WZ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:MPP7
gene id: 9685:MPP7
uniprot id: A0A5F5XJ14
uniprot id: M3WAD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: adherens junction
messages: tight junction

9685:SLC1A4
gene id: 9685:SLC1A4
uniprot id: A0A2I2UTT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9685:EIF4EBP2
gene id: 9685:EIF4EBP2
uniprot id: A0A2I2UNS0
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9685:WAS
gene id: 9685:WAS
uniprot id: M3WNI4
names: Subcellular Location Annotation
messages: Nucleus

9685:CHPF2
gene id: 9685:CHPF2
uniprot id: M3WIF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9685:PNPLA1
gene id: 9685:PNPLA1
uniprot id: M3VX77
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:N6AMT1
gene id: 9685:N6AMT1
uniprot id: A0A337S4T8
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

9685:ABCB11
gene id: 9685:ABCB11
uniprot id: V5RGD6
names: Subcellular Location Annotation
messages: Endosome

9685:SLC25A2
gene id: 9685:SLC25A2
uniprot id: A0A337SBD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:TMEM230
gene id: 9685:TMEM230
uniprot id: A0A2I2UEA0
uniprot id: A0A5F5XLT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9685:LOC102902084
gene id: 9685:LOC102902084
uniprot id: A0A5F5Y2V8
names: Similarity
messages: Belongs to the MS4A family.

9685:ARID5B
gene id: 9685:ARID5B
uniprot id: A0A2I2U4D2
uniprot id: A0A337SR71
names: Similarity
messages: Belongs to the ARID5B family.

9685:MAPK1IP1L
gene id: 9685:MAPK1IP1L
uniprot id: A0A2I2U8A9
names: Similarity
messages: Belongs to the MISS family.

9685:INTS7
gene id: 9685:INTS7
uniprot id: M3WAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9685:ELAC1
gene id: 9685:ELAC1
uniprot id: A0A2I2UYF7
names: Subunit
messages: Homodimer.

9685:DNTTIP1
gene id: 9685:DNTTIP1
uniprot id: A0A2I2UZ74
names: Subcellular Location Annotation
messages: Nucleus

9685:CES5A
gene id: 9685:CES5A
uniprot id: Q8I034
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Carboxylesterase present at high level in urine that regulates production of felinine, a probable pheromone precursor. Probably acts by hydrolyzing the peptide bond of the felinine precursor 3-methylbutanol cyteinylglycine, producing felinine and glycine in cat urine.
messages: N-glycosylated; contains a fucosylated complex carbohydrate.
messages: Present at high level in urine. Expressed in the kidney proximal straight tubular cells and is secreted from the apical compartment of the cells into the urine (at protein level). In mature cats, it is present at higher level in intact males than in castrated males or in intact or spayed females.
messages: Present in cats older than about 3 months, and its level increases with age.
messages: Protein specifically present in urine of cat. Present at high level in urine of members of the genus Felis and Lynx but not in urine of other felines.
messages: Secreted
messages: Strongly down-regulated in cats suffering from tubulointerstitial nephritis (TIN). Excretion decreases immediately after castration.

9685:CHI3L1
gene id: 9685:CHI3L1
uniprot id: A0A2I2UDB3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Endoplasmic reticulum
messages: Monomer.
messages: extracellular space
messages: perinuclear region

9685:RRP12
gene id: 9685:RRP12
uniprot id: A0A2I2UUU0
names: Similarity
messages: Belongs to the RRP12 family.

9685:ZFYVE16
gene id: 9685:ZFYVE16
uniprot id: M3X9A9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9685:NXPH1
gene id: 9685:NXPH1
uniprot id: M3W6B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9685:CALB2
gene id: 9685:CALB2
uniprot id: M3WCV4
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9685:SNRNP27
gene id: 9685:SNRNP27
uniprot id: M3WYQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9685:ERG28
gene id: 9685:ERG28
uniprot id: M3WK97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:LRP1
gene id: 9685:LRP1
uniprot id: M3VU91
uniprot id: M3X7K5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:NXT1
gene id: 9685:NXT1
uniprot id: M3W5Z3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9685:CDIPT
gene id: 9685:CDIPT
uniprot id: M3WK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9685:DHRS3
gene id: 9685:DHRS3
uniprot id: M3VV13
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:IAPP
gene id: 9685:IAPP
uniprot id: P12967
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calcitonin family.
messages: Interacts with IDE and INS.
messages: Secreted
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
messages: The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates.

9685:HGF
gene id: 9685:HGF
uniprot id: Q9BH09
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity (By similarity).
messages: Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity).

9685:TYROBP
gene id: 9685:TYROBP
uniprot id: M3W675
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9685:LOC101082580
gene id: 9685:LOC101082580
uniprot id: M3WVU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:XPNPEP2
gene id: 9685:XPNPEP2
uniprot id: M3W8X1
names: Similarity
messages: Belongs to the peptidase M24B family.

9685:GDF2
gene id: 9685:GDF2
uniprot id: A0A2I2U4I8
names: Similarity
messages: Belongs to the TGF-beta family.

9685:TFR2
gene id: 9685:TFR2
uniprot id: M3W6L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9685:LOC101088952
gene id: 9685:LOC101088952
uniprot id: A0A337S5E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SPOUT1
gene id: 9685:SPOUT1
uniprot id: M3XBQ2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

9685:SFXN5
gene id: 9685:SFXN5
uniprot id: A0A337S7F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9685:G6PC2
gene id: 9685:G6PC2
uniprot id: M3W5B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9685:DCLK2
gene id: 9685:DCLK2
uniprot id: A0A2I2UJ98
uniprot id: A0A2I2UVM1
uniprot id: M3WCD0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9685:PDE5A
gene id: 9685:PDE5A
uniprot id: A0A2I2UUN8
uniprot id: A0A2I2V373
uniprot id: F1CNG6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9685:CMC4
gene id: 9685:CMC4
uniprot id: M3WVW6
names: Similarity
messages: Belongs to the CMC4 family.

9685:DLAT
gene id: 9685:DLAT
uniprot id: M3WN19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9685:TCP11L1
gene id: 9685:TCP11L1
uniprot id: M3X7I2
names: Similarity
messages: Belongs to the TCP11 family.

9685:CDH24
gene id: 9685:CDH24
uniprot id: A0A337SEZ0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9685:LOC101088329
gene id: 9685:LOC101088329
uniprot id: M3XEP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9685:TSPAN7
gene id: 9685:TSPAN7
uniprot id: M3WE14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:SDC4
gene id: 9685:SDC4
uniprot id: M3X6M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Membrane

9685:ATP5F1A
gene id: 9685:ATP5F1A
uniprot id: M3WZB0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9685:LDB3
gene id: 9685:LDB3
uniprot id: A0A2I2U675
uniprot id: M3WLS6
names: Subcellular Location Annotation
messages: Z line

9685:TMBIM1
gene id: 9685:TMBIM1
uniprot id: M3VYE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9685:TAAR9
gene id: 9685:TAAR9
uniprot id: M3WV25
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:PARP16
gene id: 9685:PARP16
uniprot id: A0A2I2V4V7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9685:LIN7A
gene id: 9685:LIN7A
uniprot id: M3WLS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9685:SERPINA6
gene id: 9685:SERPINA6
uniprot id: M3WCX0
names: Similarity
messages: Belongs to the serpin family.

9685:NUPR1
gene id: 9685:NUPR1
uniprot id: M3WGP0
names: Similarity
messages: Belongs to the NUPR family.

9685:CDK4
gene id: 9685:CDK4
uniprot id: M3WUQ1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:PRMT5
gene id: 9685:PRMT5
uniprot id: M3W690
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9685:LOC101100977
gene id: 9685:LOC101100977
uniprot id: M3VX43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GPC6
gene id: 9685:GPC6
uniprot id: M3X6B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9685:RPS26
gene id: 9685:RPS26
uniprot id: M3WJU8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9685:GK2
gene id: 9685:GK2
uniprot id: A0A337SAZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9685:RGN
gene id: 9685:RGN
uniprot id: A0A337SL03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

9685:RPS15
gene id: 9685:RPS15
uniprot id: A0A2I2UE94
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

9685:EFNB3
gene id: 9685:EFNB3
uniprot id: B0LDT1
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:MINDY4
gene id: 9685:MINDY4
uniprot id: M3WF31
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9685:MED8
gene id: 9685:MED8
uniprot id: A0A337SH70
uniprot id: A0A337SII9
uniprot id: A0A5F5XWV9
uniprot id: M3WLZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9685:MGAT2
gene id: 9685:MGAT2
uniprot id: A0A5F5XW65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

9685:DNAAF2
gene id: 9685:DNAAF2
uniprot id: M3XFH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

9685:SERINC5
gene id: 9685:SERINC5
uniprot id: M3W150
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

9685:DUS4L
gene id: 9685:DUS4L
uniprot id: M3W2R5
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9685:LOC101094593
gene id: 9685:LOC101094593
uniprot id: M3WLP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9685:MAP4K1
gene id: 9685:MAP4K1
uniprot id: A0A337SHY9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9685:REXO2
gene id: 9685:REXO2
uniprot id: M3WPD6
names: Similarity
messages: Belongs to the oligoribonuclease family.

9685:GRIK2
gene id: 9685:GRIK2
uniprot id: A0A2I2U4F7
uniprot id: A0A2I2U739
uniprot id: A0A337S2R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9685:LAMB2
gene id: 9685:LAMB2
uniprot id: M3WC88
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9685:FADS6
gene id: 9685:FADS6
uniprot id: M3X8E3
names: Similarity
messages: Belongs to the fatty acid desaturase type 1 family.

9685:UBE2L6
gene id: 9685:UBE2L6
uniprot id: M3XBX1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9685:LOC101100421
gene id: 9685:LOC101100421
uniprot id: A0A5F5XWS7
uniprot id: M3XDZ0
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

9685:PLSCR3
gene id: 9685:PLSCR3
uniprot id: M3WE53
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9685:CASP2
gene id: 9685:CASP2
uniprot id: A0A2I2UIE2
uniprot id: A0A5F5XGT3
names: Similarity
messages: Belongs to the peptidase C14A family.

9685:COX8A
gene id: 9685:COX8A
uniprot id: M3WL37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9685:AGAP2
gene id: 9685:AGAP2
uniprot id: A0A2I2U3J0
uniprot id: A0A2I2UDH6
uniprot id: M3WL60
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9685:KYNU
gene id: 9685:KYNU
uniprot id: A0A5F5XMX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:COL4A6
gene id: 9685:COL4A6
uniprot id: A0A337SDB4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9685:HOGA1
gene id: 9685:HOGA1
uniprot id: M3XDF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9685:GPR55
gene id: 9685:GPR55
uniprot id: M3XD37
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:CARNMT1
gene id: 9685:CARNMT1
uniprot id: M3WWU8
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

9685:LOC101099693
gene id: 9685:LOC101099693
uniprot id: M3XAA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:EFNB2
gene id: 9685:EFNB2
uniprot id: B0LDS5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:RDH16
gene id: 9685:RDH16
uniprot id: A0A5F5Y323
uniprot id: M3WKX4
uniprot id: M3XG87
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:ACKR1
gene id: 9685:ACKR1
uniprot id: A0A337S1Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

9685:GALNT5
gene id: 9685:GALNT5
uniprot id: M3W7T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9685:RAB11FIP4
gene id: 9685:RAB11FIP4
uniprot id: A0A2I2US40
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

9685:DESI1
gene id: 9685:DESI1
uniprot id: A0A2I2UWM2
names: Similarity
messages: Belongs to the DeSI family.

9685:ATG4A
gene id: 9685:ATG4A
uniprot id: M3W3M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9685:CENPQ
gene id: 9685:CENPQ
uniprot id: M3XB93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9685:MTX3
gene id: 9685:MTX3
uniprot id: A0A2I2U4U1
uniprot id: A0A337SKE3
uniprot id: M3W146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9685:TPMT
gene id: 9685:TPMT
uniprot id: M3W1W1
uniprot id: Q6EIC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9685:NDUFV1
gene id: 9685:NDUFV1
uniprot id: M3VX83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9685:SEPTIN7
gene id: 9685:SEPTIN7
uniprot id: A0A337RWB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium axoneme
messages: flagellum
messages: kinetochore
messages: spindle

9685:FAM126A
gene id: 9685:FAM126A
uniprot id: A0A2I2UHH9
uniprot id: M3WEC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9685:PSMB10
gene id: 9685:PSMB10
uniprot id: M3WHR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9685:COPB1
gene id: 9685:COPB1
uniprot id: M3WF04
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9685:MDH1
gene id: 9685:MDH1
uniprot id: Q7YRU4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation.
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation.
messages: Cytoplasm
messages: Homodimer.
messages: ISGylated.

9685:ZNF706
gene id: 9685:ZNF706
uniprot id: A0A337SAK6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9685:SMG8
gene id: 9685:SMG8
uniprot id: M3WIN9
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

9685:LOC101098254
gene id: 9685:LOC101098254
uniprot id: M3WJD9
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9685:ZNF280D
gene id: 9685:ZNF280D
uniprot id: M3XDA6
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9685:ITGA4
gene id: 9685:ITGA4
uniprot id: M3WE16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9685:CASP9
gene id: 9685:CASP9
uniprot id: A0A337SNV2
uniprot id: M3WUW6
names: Similarity
messages: Belongs to the peptidase C14A family.

9685:KCNB1
gene id: 9685:KCNB1
uniprot id: M3WBK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: sarcolemma
messages: synaptosome

9685:SERP1
gene id: 9685:SERP1
uniprot id: M3WEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9685:VPS53
gene id: 9685:VPS53
uniprot id: M3VX26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9685:SMU1
gene id: 9685:SMU1
uniprot id: M3WA50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9685:WDR35
gene id: 9685:WDR35
uniprot id: A0A2I2UE42
uniprot id: A0A2I2V4H6
names: Function
names: Subcellular Location Annotation
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: centrosome
messages: cilium basal body

9685:MRPL41
gene id: 9685:MRPL41
uniprot id: M3W0L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9685:LOC101089393
gene id: 9685:LOC101089393
uniprot id: A0A2I2U307
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MCM4
gene id: 9685:MCM4
uniprot id: M3WF03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9685:FGF12
gene id: 9685:FGF12
uniprot id: A0A2I2UI28
uniprot id: A0A337SQT3
uniprot id: M3X809
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9685:WDR83OS
gene id: 9685:WDR83OS
uniprot id: M3VUT6
names: Similarity
messages: Belongs to the Asterix family.

9685:LHFPL5
gene id: 9685:LHFPL5
uniprot id: A0A2I2UET4
uniprot id: A0A5F5Y450
names: Subcellular Location Annotation
messages: Membrane

9685:RBP5
gene id: 9685:RBP5
uniprot id: A0A2I2V3N2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9685:CA6
gene id: 9685:CA6
uniprot id: A0A337SFR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide. Its role in saliva is unknown.
messages: Secreted

9685:LOC101091916
gene id: 9685:LOC101091916
uniprot id: M3WRL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:GNA13
gene id: 9685:GNA13
uniprot id: M3X9G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9685:CMTR1
gene id: 9685:CMTR1
uniprot id: A0A2I2U4S4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9685:FGFR1OP2
gene id: 9685:FGFR1OP2
uniprot id: A0A337S2K4
uniprot id: M3XD60
names: Similarity
messages: Belongs to the SIKE family.

9685:KIT
gene id: 9685:KIT
uniprot id: D7PDD5
uniprot id: Q28889
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3CD. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
messages: Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.
messages: Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Activity is down-regulated by PRKCA-mediated phosphorylation on serine residues (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).
messages: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation.

9685:PAX1
gene id: 9685:PAX1
uniprot id: M3W1Y0
names: Subcellular Location Annotation
messages: Nucleus

9685:SFXN4
gene id: 9685:SFXN4
uniprot id: M3WDN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9685:LOC101090380
gene id: 9685:LOC101090380
uniprot id: M3XAC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LSM4
gene id: 9685:LSM4
uniprot id: M3W8L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9685:RAB29
gene id: 9685:RAB29
uniprot id: M3WYE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9685:CETN1
gene id: 9685:CETN1
uniprot id: M3WB11
names: Similarity
messages: Belongs to the centrin family.

9685:TMEM184A
gene id: 9685:TMEM184A
uniprot id: M3WP43
names: Subcellular Location Annotation
messages: Membrane

9685:CAMK1G
gene id: 9685:CAMK1G
uniprot id: A0A5K1UNP7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:MTMR4
gene id: 9685:MTMR4
uniprot id: A0A2I2UU55
uniprot id: M3W297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9685:SSTR2
gene id: 9685:SSTR2
uniprot id: M3W2Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9685:RGS2
gene id: 9685:RGS2
uniprot id: M3X7Y3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

9685:PNPT1
gene id: 9685:PNPT1
uniprot id: A0A5F5XS63
uniprot id: M3WIH2
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

9685:LIPM
gene id: 9685:LIPM
uniprot id: A0A337SEA4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9685:TNFSF4
gene id: 9685:TNFSF4
uniprot id: A0S0B2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9685:SPEM2
gene id: 9685:SPEM2
uniprot id: M3WH76
names: Subcellular Location Annotation
messages: Membrane

9685:FELCATV1R14
gene id: 9685:FELCATV1R14
uniprot id: M3WW79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:PSMD12
gene id: 9685:PSMD12
uniprot id: M3X366
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9685:LOC101082181
gene id: 9685:LOC101082181
uniprot id: M3XG50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101097234
gene id: 9685:LOC101097234
uniprot id: M3XDF4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CHMP4C
gene id: 9685:CHMP4C
uniprot id: M3XDE0
names: Similarity
messages: Belongs to the SNF7 family.

9685:KCNJ13
gene id: 9685:KCNJ13
uniprot id: A0A5F5XK79
uniprot id: M3VZI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9685:KHDC4
gene id: 9685:KHDC4
uniprot id: A0A337S9E5
names: Similarity
messages: Belongs to the KHDC4 family.

9685:PDCD4
gene id: 9685:PDCD4
uniprot id: M3WFY9
names: Similarity
messages: Belongs to the PDCD4 family.

9685:S100A1
gene id: 9685:S100A1
uniprot id: M3XA34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Mitochondrion

9685:FLOT2
gene id: 9685:FLOT2
uniprot id: A0A2I2UNG0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane

9685:EXOSC1
gene id: 9685:EXOSC1
uniprot id: A0A337S7M7
uniprot id: A0A337SMU4
names: Subcellular Location Annotation
messages: Cytoplasm

9685:PPEF2
gene id: 9685:PPEF2
uniprot id: M3W5Y3
names: Similarity
messages: Belongs to the PPP phosphatase family.

9685:CNFN
gene id: 9685:CNFN
uniprot id: M3WHI3
names: Similarity
messages: Belongs to the cornifelin family.

9685:GDF3
gene id: 9685:GDF3
uniprot id: M3WCE8
names: Similarity
messages: Belongs to the TGF-beta family.

9685:HSD3B2
gene id: 9685:HSD3B2
uniprot id: F5CSS4
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9685:TMEM106C
gene id: 9685:TMEM106C
uniprot id: M3WJW5
names: Similarity
messages: Belongs to the TMEM106 family.

9685:LOC101100998
gene id: 9685:LOC101100998
uniprot id: M3WWB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MUS81
gene id: 9685:MUS81
uniprot id: A0A5F5XRX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

9685:GSDMA
gene id: 9685:GSDMA
uniprot id: M3WLQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9685:SEMA3F
gene id: 9685:SEMA3F
uniprot id: A0A2I2U3B1
uniprot id: M3W6X0
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:COA7
gene id: 9685:COA7
uniprot id: A0A2I2UGG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space

9685:GTF2H1
gene id: 9685:GTF2H1
uniprot id: M3W751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9685:ANKRD34A
gene id: 9685:ANKRD34A
uniprot id: A0A5F5XJL7
names: Similarity
messages: Belongs to the ANKRD34 family.

9685:TLR10
gene id: 9685:TLR10
uniprot id: M3W849
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9685:PIGL
gene id: 9685:PIGL
uniprot id: M3WE00
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9685:BTG2
gene id: 9685:BTG2
uniprot id: M3WSJ8
names: Similarity
messages: Belongs to the BTG family.

9685:ENPP4
gene id: 9685:ENPP4
uniprot id: A0A2I2U6N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

9685:SENP8
gene id: 9685:SENP8
uniprot id: M3VV62
names: Similarity
messages: Belongs to the peptidase C48 family.

9685:PLA2G5
gene id: 9685:PLA2G5
uniprot id: M3W328
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9685:ELMO1
gene id: 9685:ELMO1
uniprot id: M3W2J8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9685:VBP1
gene id: 9685:VBP1
uniprot id: M3WX04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9685:LOC101094372
gene id: 9685:LOC101094372
uniprot id: M3XE81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:FZD1
gene id: 9685:FZD1
uniprot id: M3X4M3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:PRKAR2A
gene id: 9685:PRKAR2A
uniprot id: A0A337S4R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9685:CCNE2
gene id: 9685:CCNE2
uniprot id: M3X5A2
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9685:MED23
gene id: 9685:MED23
uniprot id: A0A2I2UME4
uniprot id: M3WA80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

9685:RHBDD2
gene id: 9685:RHBDD2
uniprot id: M3X5I8
names: Subcellular Location Annotation
messages: Membrane

9685:ADAM22
gene id: 9685:ADAM22
uniprot id: A0A2I2UK80
uniprot id: A0A337SAP5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:UFD1
gene id: 9685:UFD1
uniprot id: M3W1Y3
names: Similarity
messages: Belongs to the UFD1 family.

9685:LOC101086252
gene id: 9685:LOC101086252
uniprot id: M3X8C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MS4A1
gene id: 9685:MS4A1
uniprot id: Q5R1M8
names: Similarity
messages: Belongs to the MS4A family.

9685:EEF1G
gene id: 9685:EEF1G
uniprot id: M3WAC5
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9685:TENM1
gene id: 9685:TENM1
uniprot id: M3W9F8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:TRNAU1AP
gene id: 9685:TRNAU1AP
uniprot id: M3WIT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9685:NOC4L
gene id: 9685:NOC4L
uniprot id: M3WDX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane

9685:MASP1
gene id: 9685:MASP1
uniprot id: A0A2I2UHZ6
uniprot id: A0A337S0B1
uniprot id: A0A5F5XKI9
uniprot id: M3WE59
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:CHD8
gene id: 9685:CHD8
uniprot id: M3WJL6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

9685:RPS29
gene id: 9685:RPS29
uniprot id: A0A337SCP7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9685:INO80C
gene id: 9685:INO80C
uniprot id: M3W031
names: Subcellular Location Annotation
messages: Nucleus

9685:KCNU1
gene id: 9685:KCNU1
uniprot id: A0A5F5XLZ3
uniprot id: M3WPE1
names: Subcellular Location Annotation
messages: Membrane

9685:GPN2
gene id: 9685:GPN2
uniprot id: M3WHP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9685:SCPEP1
gene id: 9685:SCPEP1
uniprot id: M3WQ85
names: Similarity
messages: Belongs to the peptidase S10 family.

9685:SRPX2
gene id: 9685:SRPX2
uniprot id: M3W039
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

9685:KHDRBS3
gene id: 9685:KHDRBS3
uniprot id: M3VUB9
names: Similarity
messages: Belongs to the KHDRBS family.

9685:TYRP1
gene id: 9685:TYRP1
uniprot id: Q2VPW6
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allelic variations in TYRP1 may be associated with brown (allele chocolate) or cinnamon (allele cinnamon) coat color in domestic cats.
messages: Belongs to the tyrosinase family.
messages: Contains bound zinc ions after heterologous expression in insect cells, giving rise to a protein that lacks DHICA oxidase activity.
messages: May be due to competing donor splice site.
messages: Melanosome membrane
messages: Monomer (By similarity). Interacts with ATP7A (By similarity). Interacts with SLC45A2 (By similarity).
messages: Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized (By similarity). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
messages: The activity depends critically on the nature of the bound metal ion. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) in the presence of bound Cu(2+) ions, but lacks activity in the presence of bound Zn(2+) ions.

9685:ACADL
gene id: 9685:ACADL
uniprot id: M3WYQ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

9685:PRKCD
gene id: 9685:PRKCD
uniprot id: M3W161
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9685:MAN1A2
gene id: 9685:MAN1A2
uniprot id: M3WPE4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9685:PRKCG
gene id: 9685:PRKCG
uniprot id: M3VWV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane

9685:PITX2
gene id: 9685:PITX2
uniprot id: A0A2I2U1X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9685:HNRNPK
gene id: 9685:HNRNPK
uniprot id: A0A2I2UI32
uniprot id: A0A5F5XI44
uniprot id: M3WLH7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9685:FGD6
gene id: 9685:FGD6
uniprot id: A0A2I2U1M7
uniprot id: A0A5F5Y6C8
names: Subcellular Location Annotation
messages: cytoskeleton

9685:KIF20A
gene id: 9685:KIF20A
uniprot id: M3VX50
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:BCL2L2
gene id: 9685:BCL2L2
uniprot id: A0A2I2UAE3
names: Similarity
messages: Belongs to the Bcl-2 family.

9685:TSHZ2
gene id: 9685:TSHZ2
uniprot id: M3WL06
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

9685:LOC102902042
gene id: 9685:LOC102902042
uniprot id: A0A5F5XPA5
names: Similarity
messages: Belongs to the MS4A family.

9685:DSCC1
gene id: 9685:DSCC1
uniprot id: M3WE83
names: Similarity
messages: Belongs to the DCC1 family.

9685:SLC2A9
gene id: 9685:SLC2A9
uniprot id: A0A2I2UUJ8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9685:HNF4G
gene id: 9685:HNF4G
uniprot id: M3X5S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9685:LAMP3
gene id: 9685:LAMP3
uniprot id: A0A2I2V3S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9685:DSG4
gene id: 9685:DSG4
uniprot id: M3WTD0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9685:SCNN1A
gene id: 9685:SCNN1A
uniprot id: A0A2I2URC6
names: Subcellular Location Annotation
messages: Membrane

9685:NPY1R
gene id: 9685:NPY1R
uniprot id: M3W4X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:MGST2
gene id: 9685:MGST2
uniprot id: M3X1T6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9685:LOC768284
gene id: 9685:LOC768284
uniprot id: M3X1P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9685:DCTPP1
gene id: 9685:DCTPP1
uniprot id: A0A2I2U2J4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9685:IFT122
gene id: 9685:IFT122
uniprot id: A0A2I2UPT3
names: Subcellular Location Annotation
messages: cilium

9685:ACTL7B
gene id: 9685:ACTL7B
uniprot id: M3WY90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9685:LOC101095073
gene id: 9685:LOC101095073
uniprot id: M3XEZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TAAR4
gene id: 9685:TAAR4
uniprot id: A0A2I2U7I9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:DYNLT1
gene id: 9685:DYNLT1
uniprot id: M3W8R7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9685:CALCRL
gene id: 9685:CALCRL
uniprot id: A0A337SIF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9685:SLC17A8
gene id: 9685:SLC17A8
uniprot id: M3WNE7
names: Subcellular Location Annotation
messages: Membrane

9685:APOC1
gene id: 9685:APOC1
uniprot id: P0DM82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C1 family.
messages: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
messages: Secreted

9685:TMEM255A
gene id: 9685:TMEM255A
uniprot id: A0A337SRP5
uniprot id: M3WLM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9685:LOC101092166
gene id: 9685:LOC101092166
uniprot id: A0A5F5XHA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MTFMT
gene id: 9685:MTFMT
uniprot id: M3X767
names: Similarity
messages: Belongs to the Fmt family.

9685:CD1H11orf49
gene id: 9685:CD1H11orf49
uniprot id: A0A2I2TZV6
uniprot id: M3VYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: centriolar satellite

9685:IPO7
gene id: 9685:IPO7
uniprot id: M3XA23
names: Subcellular Location Annotation
messages: Cytoplasm

9685:FUT8
gene id: 9685:FUT8
uniprot id: A0A2I2U0C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9685:RARG
gene id: 9685:RARG
uniprot id: A0A2I2U5U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9685:CA2H7orf25
gene id: 9685:CA2H7orf25
uniprot id: M3WJB3
names: Similarity
messages: Belongs to the UPF0415 family.

9685:FGF17
gene id: 9685:FGF17
uniprot id: M3W464
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9685:CCK
gene id: 9685:CCK
uniprot id: M3W5D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9685:S100PBP
gene id: 9685:S100PBP
uniprot id: M3W0L2
names: Subcellular Location Annotation
messages: Nucleus

9685:TLCD3B
gene id: 9685:TLCD3B
uniprot id: M3WK74
names: Subcellular Location Annotation
messages: Membrane

9685:GJA9
gene id: 9685:GJA9
uniprot id: A0A2I2U7D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:ZNF446
gene id: 9685:ZNF446
uniprot id: A0A2I2UXH8
names: Subcellular Location Annotation
messages: Nucleus

9685:TXNIP
gene id: 9685:TXNIP
uniprot id: M3XA24
names: Similarity
messages: Belongs to the arrestin family.

9685:LOC101084569
gene id: 9685:LOC101084569
uniprot id: M3X020
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ACSL4
gene id: 9685:ACSL4
uniprot id: A0A2I2UET1
uniprot id: A0A5K1UM18
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9685:CADM1
gene id: 9685:CADM1
uniprot id: A0A337SBC7
names: Similarity
messages: Belongs to the nectin family.

9685:EDN1
gene id: 9685:EDN1
uniprot id: M3WLG0
uniprot id: Q5NRQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
messages: Secreted

9685:POLA1
gene id: 9685:POLA1
uniprot id: M3VXZ0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

9685:TMEM87A
gene id: 9685:TMEM87A
uniprot id: M3WU12
names: Subcellular Location Annotation
messages: Membrane

9685:VTI1A
gene id: 9685:VTI1A
uniprot id: A0A2I2U8I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9685:ASAH1
gene id: 9685:ASAH1
uniprot id: A0A2I2V0N3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9685:UBE2C
gene id: 9685:UBE2C
uniprot id: M3VXG6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9685:COPS4
gene id: 9685:COPS4
uniprot id: A0A337SDG9
uniprot id: M3XBM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9685:STX18
gene id: 9685:STX18
uniprot id: M3XAH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9685:IMMP1L
gene id: 9685:IMMP1L
uniprot id: M3X386
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9685:DLC1
gene id: 9685:DLC1
uniprot id: A0A5F5XMR8
uniprot id: A0A5F5XRG1
uniprot id: A0A5F5Y519
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
messages: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.
messages: Membrane
messages: focal adhesion

9685:SLC6A1
gene id: 9685:SLC6A1
uniprot id: A0A2I2UPJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9685:DLX2
gene id: 9685:DLX2
uniprot id: A0A2I2U019
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9685:APOL6
gene id: 9685:APOL6
uniprot id: A0A337S9J7
names: Similarity
messages: Belongs to the apolipoprotein L family.

9685:MRPL4
gene id: 9685:MRPL4
uniprot id: A0A5F5XS96
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9685:TRAPPC4
gene id: 9685:TRAPPC4
uniprot id: M3VW28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9685:EEF2
gene id: 9685:EEF2
uniprot id: M3VVM1
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

9685:NSG2
gene id: 9685:NSG2
uniprot id: M3XC96
names: Similarity
messages: Belongs to the NSG family.

9685:MAGT1
gene id: 9685:MAGT1
uniprot id: M3X2H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:NTRK3
gene id: 9685:NTRK3
uniprot id: A0A337RW69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9685:POLR2B
gene id: 9685:POLR2B
uniprot id: A0A337SUE0
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9685:LOC105260757
gene id: 9685:LOC105260757
uniprot id: M3W082
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LAMB3
gene id: 9685:LAMB3
uniprot id: M3WM02
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LPIN2
gene id: 9685:LPIN2
uniprot id: M3WQ22
names: Similarity
messages: Belongs to the lipin family.

9685:IL33
gene id: 9685:IL33
uniprot id: M3WAQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9685:CXCL8
gene id: 9685:CXCL8
uniprot id: Q9XSX5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
messages: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
messages: Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.
messages: Secreted

9685:TBC1D23
gene id: 9685:TBC1D23
uniprot id: M3W963
names: Subcellular Location Annotation
messages: trans-Golgi network

9685:BANF1
gene id: 9685:BANF1
uniprot id: A0A2I2UEU9
names: Subcellular Location Annotation
messages: Nucleus

9685:TMEM242
gene id: 9685:TMEM242
uniprot id: A0A2I2UIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9685:DDX21
gene id: 9685:DDX21
uniprot id: A0A2I2V1N2
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9685:MRPL19
gene id: 9685:MRPL19
uniprot id: M3WYB9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9685:CD8A
gene id: 9685:CD8A
uniprot id: P41688
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked heterodimers with CD8B at the cell surface. Forms also homodimers in several cell types including NK-cells or peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.
messages: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
messages: O-glycosylated.
messages: Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.
messages: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.

9685:PRKCI
gene id: 9685:PRKCI
uniprot id: M3XF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9685:PDYN
gene id: 9685:PDYN
uniprot id: A0A2I2V0Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
messages: Secreted

9685:RPS12
gene id: 9685:RPS12
uniprot id: A0A2I2U1K1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9685:CYP17A1
gene id: 9685:CYP17A1
uniprot id: Q9GMC8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity.

9685:LSM12
gene id: 9685:LSM12
uniprot id: A0A2I2UQ30
names: Similarity
messages: Belongs to the LSM12 family.

9685:RAPGEF2
gene id: 9685:RAPGEF2
uniprot id: A0A337S3J3
uniprot id: A0A337SH57
uniprot id: M3W7J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAPGEF2 family.
messages: Cell junction
messages: Endosome
messages: Late endosome
messages: perinuclear region

9685:LOC101081992
gene id: 9685:LOC101081992
uniprot id: M3WIX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9685:EHF
gene id: 9685:EHF
uniprot id: A0A2I2UPF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:AURKB
gene id: 9685:AURKB
uniprot id: A0A5F5XIA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centromere

9685:PRKCQ
gene id: 9685:PRKCQ
uniprot id: A0A337S2V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9685:MMS19
gene id: 9685:MMS19
uniprot id: M3WIU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9685:LIPH
gene id: 9685:LIPH
uniprot id: A0A337S3D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9685:TLR8
gene id: 9685:TLR8
uniprot id: B2BE52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9685:PLA2G4E
gene id: 9685:PLA2G4E
uniprot id: A0A5F5XLL6
uniprot id: M3W7K6
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9685:PPIF
gene id: 9685:PPIF
uniprot id: M3XFI8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9685:S100A16
gene id: 9685:S100A16
uniprot id: A0A2I2U4Z5
names: Similarity
messages: Belongs to the S-100 family.

9685:ATF4
gene id: 9685:ATF4
uniprot id: M3WB57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9685:ABCC2
gene id: 9685:ABCC2
uniprot id: A0A5F5Y6K4
uniprot id: M3WKM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9685:HSPA2
gene id: 9685:HSPA2
uniprot id: M3W8G1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9685:VPS26C
gene id: 9685:VPS26C
uniprot id: A0A2I2U0M6
names: Similarity
messages: Belongs to the VPS26 family.

9685:HSD17B3
gene id: 9685:HSD17B3
uniprot id: M3VZ12
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:RNF167
gene id: 9685:RNF167
uniprot id: A0A2I2UIU2
names: Subcellular Location Annotation
messages: Membrane

9685:BUD23
gene id: 9685:BUD23
uniprot id: M3W2S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9685:MOCS2
gene id: 9685:MOCS2
uniprot id: M3WV85
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9685:PDHB
gene id: 9685:PDHB
uniprot id: M3VY34
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9685:LOC101083537
gene id: 9685:LOC101083537
uniprot id: A0A5F5Y6U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:KATNA1
gene id: 9685:KATNA1
uniprot id: M3WEU7
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

9685:LOC101101581
gene id: 9685:LOC101101581
uniprot id: A0A2I2UCT5
uniprot id: M3W589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Belongs to the ADP-ribosylglycohydrolase family.
messages: Secreted

9685:QRFPR
gene id: 9685:QRFPR
uniprot id: M3WYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9685:PRRC1
gene id: 9685:PRRC1
uniprot id: A0A5F5XRL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

9685:ACAD8
gene id: 9685:ACAD8
uniprot id: M3W7P8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9685:GMPPA
gene id: 9685:GMPPA
uniprot id: M3WU81
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9685:LPAR1
gene id: 9685:LPAR1
uniprot id: M3WVC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9685:AHDC1
gene id: 9685:AHDC1
uniprot id: M3W8J2
names: Subcellular Location Annotation
messages: Nucleus

9685:GGT5
gene id: 9685:GGT5
uniprot id: M3X9T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9685:CSTA
gene id: 9685:CSTA
uniprot id: Q8WNR9
names: Allergen
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Causes an allergic reaction in human. Binds to IgE.
messages: Cytoplasm
messages: This is an intracellular thiol proteinase inhibitor.

9685:CPSF4
gene id: 9685:CPSF4
uniprot id: A0A337RX23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9685:GNRHR
gene id: 9685:GNRHR
uniprot id: A0A5K1VGL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

9685:OSBPL2
gene id: 9685:OSBPL2
uniprot id: A0A2I2UB70
names: Similarity
messages: Belongs to the OSBP family.

9685:RPS24
gene id: 9685:RPS24
uniprot id: A0A2I2V211
uniprot id: A0A5F5XT31
uniprot id: M3VVI9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9685:LOC101089293
gene id: 9685:LOC101089293
uniprot id: A0A5F5XX01
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MYT1L
gene id: 9685:MYT1L
uniprot id: A0A337SDQ7
uniprot id: A0A5F5XBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9685:RND3
gene id: 9685:RND3
uniprot id: M3X4I5
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9685:MLST8
gene id: 9685:MLST8
uniprot id: M3XDU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9685:MOGS
gene id: 9685:MOGS
uniprot id: M3XE28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9685:GPR179
gene id: 9685:GPR179
uniprot id: M3W4R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9685:OSBPL5
gene id: 9685:OSBPL5
uniprot id: M3W6T5
names: Similarity
messages: Belongs to the OSBP family.

9685:TMEM267
gene id: 9685:TMEM267
uniprot id: A0A2I2UXE7
names: Subcellular Location Annotation
messages: Membrane

9685:GART
gene id: 9685:GART
uniprot id: M3WB84
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

9685:HOPX
gene id: 9685:HOPX
uniprot id: A0A2I2UJ93
names: Subcellular Location Annotation
messages: Nucleus

9685:SPC24
gene id: 9685:SPC24
uniprot id: A0A2I2UBS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9685:PPIL1
gene id: 9685:PPIL1
uniprot id: A0A2I2U8T1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9685:CNR2
gene id: 9685:CNR2
uniprot id: M3WHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:ELOVL5
gene id: 9685:ELOVL5
uniprot id: M3VV18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

9685:NUP98
gene id: 9685:NUP98
uniprot id: A0A2I2UEK3
uniprot id: M3W0W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

9685:FOXP3
gene id: 9685:FOXP3
uniprot id: A0A337S119
uniprot id: A3RJW9
uniprot id: M3W117
names: Subcellular Location Annotation
messages: Nucleus

9685:WASL
gene id: 9685:WASL
uniprot id: A0A2I2U0M1
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101100737
gene id: 9685:LOC101100737
uniprot id: A0A2I2UG91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TMEM198
gene id: 9685:TMEM198
uniprot id: M3W6A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9685:FAM227B
gene id: 9685:FAM227B
uniprot id: A0A5F5XFL0
names: Similarity
messages: Belongs to the FAM227 family.

9685:NID1
gene id: 9685:NID1
uniprot id: M3WED3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9685:B3GNT5
gene id: 9685:B3GNT5
uniprot id: M3WYR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:SLC1A6
gene id: 9685:SLC1A6
uniprot id: M3W7T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9685:PSMB7
gene id: 9685:PSMB7
uniprot id: M3WKX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9685:MCCC2
gene id: 9685:MCCC2
uniprot id: M3WJQ5
names: Similarity
messages: Belongs to the AccD/PCCB family.

9685:ARAP2
gene id: 9685:ARAP2
uniprot id: A0A2I2U0R4
names: Subcellular Location Annotation
messages: Cytoplasm

9685:RPL13A
gene id: 9685:RPL13A
uniprot id: M3WAY9
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9685:CPSF2
gene id: 9685:CPSF2
uniprot id: A0A2I2UNY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9685:XPOT
gene id: 9685:XPOT
uniprot id: A0A337SM31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9685:UHRF2
gene id: 9685:UHRF2
uniprot id: M3WUP3
names: Subcellular Location Annotation
messages: Nucleus

9685:FBL
gene id: 9685:FBL
uniprot id: M3VZK8
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9685:ENTPD8
gene id: 9685:ENTPD8
uniprot id: M3W0L3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9685:KRTAP24-1
gene id: 9685:KRTAP24-1
uniprot id: A0A337SJ69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KRTAP type 3 family.
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9685:TMCC2
gene id: 9685:TMCC2
uniprot id: A0A337SB13
names: Similarity
messages: Belongs to the TEX28 family.

9685:NKX2-8
gene id: 9685:NKX2-8
uniprot id: M3VVV2
names: Subcellular Location Annotation
messages: Nucleus

9685:CHRM1
gene id: 9685:CHRM1
uniprot id: M3VUK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9685:GABRA2
gene id: 9685:GABRA2
uniprot id: A0A337SQD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9685:RPS6KB1
gene id: 9685:RPS6KB1
uniprot id: A0A337SNA8
uniprot id: M3X5V6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9685:GDAP1
gene id: 9685:GDAP1
uniprot id: A0A337SK81
uniprot id: M3WJY6
names: Similarity
messages: Belongs to the GST superfamily.

9685:GTPBP4
gene id: 9685:GTPBP4
uniprot id: M3XAH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9685:MRPS21
gene id: 9685:MRPS21
uniprot id: A0A2I2UQC7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9685:FUT10
gene id: 9685:FUT10
uniprot id: M3W131
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9685:NUBP1
gene id: 9685:NUBP1
uniprot id: A0A337S3H3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9685:OPN1SW
gene id: 9685:OPN1SW
uniprot id: F7VJP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9685:UBA1
gene id: 9685:UBA1
uniprot id: M3VWK3
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9685:TGIF2
gene id: 9685:TGIF2
uniprot id: M3X8Q8
names: Subcellular Location Annotation
messages: Nucleus

9685:SLC6A5
gene id: 9685:SLC6A5
uniprot id: M3WZR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9685:VPS16
gene id: 9685:VPS16
uniprot id: M3VXC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9685:CLK1
gene id: 9685:CLK1
uniprot id: A0A337SR13
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:RPL4
gene id: 9685:RPL4
uniprot id: M3WGN8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9685:ATP6V1E1
gene id: 9685:ATP6V1E1
uniprot id: M3W8X9
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9685:RHBDD3
gene id: 9685:RHBDD3
uniprot id: M3W1U2
names: Subcellular Location Annotation
messages: Membrane

9685:SULT1C2
gene id: 9685:SULT1C2
uniprot id: A0A337SWQ2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9685:PTGS1
gene id: 9685:PTGS1
uniprot id: M3WEM6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CPEB4
gene id: 9685:CPEB4
uniprot id: A0A2I2UQI8
uniprot id: A0A2I2UYG8
uniprot id: A0A2I2V0Y1
uniprot id: M3WZP2
names: Similarity
messages: Belongs to the RRM CPEB family.

9685:EMC6
gene id: 9685:EMC6
uniprot id: M3W8M7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:GNGT1
gene id: 9685:GNGT1
uniprot id: M3WUX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9685:KCNK4
gene id: 9685:KCNK4
uniprot id: M3WXT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9685:SGO2
gene id: 9685:SGO2
uniprot id: M3XC61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9685:BBOF1
gene id: 9685:BBOF1
uniprot id: M3W5G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
messages: Belongs to the BBOF1 family.
messages: cilium basal body

9685:ACTL8
gene id: 9685:ACTL8
uniprot id: M3WCV2
names: Similarity
messages: Belongs to the actin family.

9685:TFCP2
gene id: 9685:TFCP2
uniprot id: M3XA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9685:PAFAH1B1
gene id: 9685:PAFAH1B1
uniprot id: B0LSW3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity. Interacts with the catalytic dimer of PAF-AH (I) heterotetrameric enzyme: interacts with PAFAH1B2 homodimer (alpha2/alpha2 homodimer), PAFAH1B3 homodimer (alpha1/alpha1 homodimer) and PAFAH1B2-PAFAH1B3 heterodimer (alpha2/alpha1 heterodimer) (By similarity). Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Interacts with INTS13. Interacts with DCDC1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity).
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

9685:PPP1R1C
gene id: 9685:PPP1R1C
uniprot id: A0A2I2U0J1
uniprot id: A0A2I2UJI1
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9685:IFI35
gene id: 9685:IFI35
uniprot id: M3X4J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9685:NDUFC2
gene id: 9685:NDUFC2
uniprot id: M3XBJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9685:LOC101101336
gene id: 9685:LOC101101336
uniprot id: M3X5C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SLITRK5
gene id: 9685:SLITRK5
uniprot id: A0A2I2UBS9
names: Similarity
messages: Belongs to the SLITRK family.

9685:FAM241B
gene id: 9685:FAM241B
uniprot id: M3WRB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9685:ARAP1
gene id: 9685:ARAP1
uniprot id: A0A337SRE2
names: Subcellular Location Annotation
messages: Cytoplasm

9685:FAM210A
gene id: 9685:FAM210A
uniprot id: M3X2D5
names: Similarity
messages: Belongs to the FAM210 family.

9685:DKK2
gene id: 9685:DKK2
uniprot id: A0A2I2U7E9
names: Similarity
messages: Belongs to the dickkopf family.

9685:ALOX5AP
gene id: 9685:ALOX5AP
uniprot id: A0A2I2UDS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:MTMR7
gene id: 9685:MTMR7
uniprot id: M3WG34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9685:ZNF394
gene id: 9685:ZNF394
uniprot id: M3XD21
names: Subcellular Location Annotation
messages: Nucleus

9685:DLL3
gene id: 9685:DLL3
uniprot id: A0A2I2UXY8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:GRWD1
gene id: 9685:GRWD1
uniprot id: M3VXX5
names: Subcellular Location Annotation
messages: Nucleus

9685:EEF1B2
gene id: 9685:EEF1B2
uniprot id: M3WCX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9685:PROKR1
gene id: 9685:PROKR1
uniprot id: A0A2I2U9C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9685:FGF9
gene id: 9685:FGF9
uniprot id: M3X6Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
messages: Secreted

9685:AK1
gene id: 9685:AK1
uniprot id: M3WX07
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

9685:CDKN1A
gene id: 9685:CDKN1A
uniprot id: O19002
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163. Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity).
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Interacts with HDAC1; the interaction is prevented by competitive binding of C10orf90/FATS to HDAC1 facilitating acetylation and protein stabilization of CDKN1A/p21 (By similarity). Interacts with MKRN1. Interacts with PSMA3. Interacts with PCNA. Component of the ternary complex, cyclin D-CDK4-CDKN1A. Interacts (via its N-terminal domain) with CDK4; the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Binding to CDK2 leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Interacts with PIM1. Interacts with STK11 and NUAK1 (By similarity). Interacts with DTL and TRIM39 (By similarity).
messages: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity).
messages: Nucleus
messages: Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances protein stability and inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. UV radiation-induced phosphorylation at Ser-146 by NUAK1 leads to its degradation.
messages: The C-terminal is required for nuclear localization of the cyclin D-CDK4 complex.
messages: The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
messages: Ubiquitinated by MKRN1; leading to polyubiquitination and 26S proteasome-dependent degradation. Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase or following UV irradiation. Ubiquitination by the DCX(DTL) complex is essential to control replication licensing and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Ubiquitination at Ser-2 leads to degradation by the proteasome pathway. Ubiquitinated by RNF114; leading to proteasomal degradation (By similarity).

9685:DYDC1
gene id: 9685:DYDC1
uniprot id: M3X070
names: Similarity
messages: Belongs to the dpy-30 family.

9685:SERPINA9
gene id: 9685:SERPINA9
uniprot id: M3WCX3
names: Similarity
messages: Belongs to the serpin family.

9685:ALG2
gene id: 9685:ALG2
uniprot id: M3X7Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

9685:INSL3
gene id: 9685:INSL3
uniprot id: A0A2I2URJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

9685:MAPKAP1
gene id: 9685:MAPKAP1
uniprot id: A0A2I2UBL2
uniprot id: A0A337S2K9
uniprot id: M3X836
names: Similarity
messages: Belongs to the SIN1 family.

9685:DDX55
gene id: 9685:DDX55
uniprot id: A0A2I2U8R4
names: Similarity
messages: Belongs to the DEAD box helicase family.

9685:SLC16A13
gene id: 9685:SLC16A13
uniprot id: A0A5F5XPP3
names: Subcellular Location Annotation
messages: Membrane

9685:TASOR
gene id: 9685:TASOR
uniprot id: A0A2I2U242
uniprot id: A0A2I2UT58
uniprot id: M3VZ74
names: Similarity
messages: Belongs to the TASOR family.

9685:EIF5
gene id: 9685:EIF5
uniprot id: M3X5W9
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

9685:LAMA2
gene id: 9685:LAMA2
uniprot id: A0A5F5XHA4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9685:PTK6
gene id: 9685:PTK6
uniprot id: A0A2I2UAA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9685:DR1
gene id: 9685:DR1
uniprot id: M3WGZ8
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9685:COG1
gene id: 9685:COG1
uniprot id: M3W2Q9
names: Similarity
messages: Belongs to the COG1 family.

9685:GSG1L2
gene id: 9685:GSG1L2
uniprot id: M3WS61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9685:MTERF2
gene id: 9685:MTERF2
uniprot id: M3WY64
names: Similarity
messages: Belongs to the mTERF family.

9685:IFNW12
gene id: 9685:IFNW12
uniprot id: Q0GYU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9685:ZDHHC6
gene id: 9685:ZDHHC6
uniprot id: M3XAK7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:DAZAP2
gene id: 9685:DAZAP2
uniprot id: A0A2I2V4Y0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9685:DYNLT2B
gene id: 9685:DYNLT2B
uniprot id: M3X1Q3
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9685:CCNA2
gene id: 9685:CCNA2
uniprot id: M3WZL5
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9685:TAF5L
gene id: 9685:TAF5L
uniprot id: M3W847
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9685:GMFG
gene id: 9685:GMFG
uniprot id: A0A2I2UH76
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9685:RPL15
gene id: 9685:RPL15
uniprot id: M3X6G6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9685:LOC101098042
gene id: 9685:LOC101098042
uniprot id: A0A2I2USR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:KIF3B
gene id: 9685:KIF3B
uniprot id: M3X169
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:GPLD1
gene id: 9685:GPLD1
uniprot id: A0A5F5XT06
uniprot id: A0A5F5XTB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

9685:LOC101084959
gene id: 9685:LOC101084959
uniprot id: M3XAW8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:SNAP25
gene id: 9685:SNAP25
uniprot id: A0A2I2UWX9
uniprot id: A0A337SVA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9685:HABP2
gene id: 9685:HABP2
uniprot id: M3WFU5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:NOC2L
gene id: 9685:NOC2L
uniprot id: M3W071
names: Similarity
messages: Belongs to the NOC2 family.

9685:PUF60
gene id: 9685:PUF60
uniprot id: A0A337SJ38
uniprot id: A0A337SVM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

9685:ZC3HC1
gene id: 9685:ZC3HC1
uniprot id: M3WD88
names: Subcellular Location Annotation
messages: Nucleus

9685:TMEM59L
gene id: 9685:TMEM59L
uniprot id: M3WC16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:MRPL46
gene id: 9685:MRPL46
uniprot id: M3WLP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9685:LOC101090388
gene id: 9685:LOC101090388
uniprot id: M3WYC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PHACTR2
gene id: 9685:PHACTR2
uniprot id: A0A2I2U295
uniprot id: M3W9U1
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9685:LOC109494610
gene id: 9685:LOC109494610
uniprot id: A0A2I2UP33
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9685:RPL17
gene id: 9685:RPL17
uniprot id: Q5XTY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9685:STEAP3
gene id: 9685:STEAP3
uniprot id: A0A2I2U8U8
uniprot id: M3W731
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9685:LOC101084866
gene id: 9685:LOC101084866
uniprot id: M3X1R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9685:TAFAZZIN
gene id: 9685:TAFAZZIN
uniprot id: M3X025
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9685:RNF34
gene id: 9685:RNF34
uniprot id: A0A2I2V3K0
names: Subcellular Location Annotation
messages: Cell membrane

9685:ACAA1
gene id: 9685:ACAA1
uniprot id: M3WHS2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9685:PARP8
gene id: 9685:PARP8
uniprot id: A0A5F5Y0R9
uniprot id: M3WNM7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9685:FAM149B1
gene id: 9685:FAM149B1
uniprot id: A0A5F5Y6N7
uniprot id: M3X367
names: Similarity
messages: Belongs to the FAM149 family.

9685:MID1IP1
gene id: 9685:MID1IP1
uniprot id: M3W296
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9685:EXOC8
gene id: 9685:EXOC8
uniprot id: M3X5S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9685:ALCAM
gene id: 9685:ALCAM
uniprot id: M3W6Y7
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9685:LOC101084283
gene id: 9685:LOC101084283
uniprot id: M3X403
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CHCHD4
gene id: 9685:CHCHD4
uniprot id: A0A337SWR1
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9685:CENPA
gene id: 9685:CENPA
uniprot id: A0A337SKR6
names: Similarity
messages: Belongs to the histone H3 family.

9685:ADK
gene id: 9685:ADK
uniprot id: A0A337SQ33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9685:DHRS9
gene id: 9685:DHRS9
uniprot id: A0A2I2UFD7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:SAP130
gene id: 9685:SAP130
uniprot id: A0A337S7Y4
uniprot id: A0A337SHX4
uniprot id: M3WWX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9685:TPRG1L
gene id: 9685:TPRG1L
uniprot id: M3WFF2
names: Similarity
messages: Belongs to the TPRG1 family.

9685:MRPL28
gene id: 9685:MRPL28
uniprot id: A0A337SG39
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

9685:CMBL
gene id: 9685:CMBL
uniprot id: M3X3U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9685:SLC1A3
gene id: 9685:SLC1A3
uniprot id: M3W493
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9685:TXLNB
gene id: 9685:TXLNB
uniprot id: M3WN09
names: Similarity
messages: Belongs to the taxilin family.

9685:NAA38
gene id: 9685:NAA38
uniprot id: A0A337S497
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

9685:IARS1
gene id: 9685:IARS1
uniprot id: M3VVG6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9685:LOC101099583
gene id: 9685:LOC101099583
uniprot id: M3X7E9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RPSA
gene id: 9685:RPSA
uniprot id: M3VZ17
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9685:BMP2
gene id: 9685:BMP2
uniprot id: A0A2I2UEZ4
names: Similarity
messages: Belongs to the TGF-beta family.

9685:RPS4X
gene id: 9685:RPS4X
uniprot id: P62705
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS4 family.
messages: Cytoplasm
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9685:RNF31
gene id: 9685:RNF31
uniprot id: M3W4B9
names: Similarity
messages: Belongs to the RBR family.

9685:CAPZB
gene id: 9685:CAPZB
uniprot id: A0A337S8B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

9685:LOC101083933
gene id: 9685:LOC101083933
uniprot id: M3WSM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:ARPC3
gene id: 9685:ARPC3
uniprot id: M3W1M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9685:TMPRSS11A
gene id: 9685:TMPRSS11A
uniprot id: M3WXP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9685:PIH1D2
gene id: 9685:PIH1D2
uniprot id: A0A337S8L6
uniprot id: M3VV32
names: Similarity
messages: Belongs to the PIH1 family.

9685:EXOC4
gene id: 9685:EXOC4
uniprot id: M3X5B6
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9685:RPL26
gene id: 9685:RPL26
uniprot id: M3WES0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9685:NAIF1
gene id: 9685:NAIF1
uniprot id: M3VWR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

9685:PDRG1
gene id: 9685:PDRG1
uniprot id: M3X889
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9685:AATF
gene id: 9685:AATF
uniprot id: A0A337SSM5
names: Similarity
messages: Belongs to the AATF family.

9685:PPP1R9A
gene id: 9685:PPP1R9A
uniprot id: A0A5F5Y4Z1
names: Subcellular Location Annotation
messages: cytoskeleton

9685:TM4SF18
gene id: 9685:TM4SF18
uniprot id: M3VWD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9685:LOC102899259
gene id: 9685:LOC102899259
uniprot id: A0A5F5Y3T4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:FITM1
gene id: 9685:FITM1
uniprot id: M3W4B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

9685:TNFRSF19
gene id: 9685:TNFRSF19
uniprot id: A0A337SPA9
uniprot id: M3WC77
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:GATA2
gene id: 9685:GATA2
uniprot id: M3W5E4
names: Subcellular Location Annotation
messages: Nucleus

9685:XRCC5
gene id: 9685:XRCC5
uniprot id: A0A5F5Y0I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus

9685:LOC101084988
gene id: 9685:LOC101084988
uniprot id: M3WU20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:AK4
gene id: 9685:AK4
uniprot id: A0A5F5XDY9
names: Similarity
messages: Belongs to the adenylate kinase family.

9685:ACLY
gene id: 9685:ACLY
uniprot id: A0A337SMT2
uniprot id: M3VXZ1
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9685:LEAP2
gene id: 9685:LEAP2
uniprot id: A0A2I2UMV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9685:CFDP1
gene id: 9685:CFDP1
uniprot id: M3X5T0
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

9685:AKT3
gene id: 9685:AKT3
uniprot id: A0A5F5XEI1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:MRPL35
gene id: 9685:MRPL35
uniprot id: A0A337SMX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9685:STX5
gene id: 9685:STX5
uniprot id: M3WLB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9685:PLOD1
gene id: 9685:PLOD1
uniprot id: M3VU17
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9685:MINDY2
gene id: 9685:MINDY2
uniprot id: A0A2I2UP04
uniprot id: A0A5F5XNU2
uniprot id: A0A5F5XPG8
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9685:AMPD1
gene id: 9685:AMPD1
uniprot id: M3WDE5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9685:SMARCAL1
gene id: 9685:SMARCAL1
uniprot id: A0A337SFL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9685:LOC101086420
gene id: 9685:LOC101086420
uniprot id: M3WWP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:UBQLN1
gene id: 9685:UBQLN1
uniprot id: A0A5F5Y5R2
uniprot id: M3XBS0
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9685:LYPD2
gene id: 9685:LYPD2
uniprot id: M3VU52
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:LOC101093429
gene id: 9685:LOC101093429
uniprot id: M3WQ30
names: Similarity
messages: Belongs to the PRORSD1 family.

9685:BCAT1
gene id: 9685:BCAT1
uniprot id: M3W9W3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9685:GALNT11
gene id: 9685:GALNT11
uniprot id: M3W9X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9685:IRF7
gene id: 9685:IRF7
uniprot id: A0A337S7B8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:PANX1
gene id: 9685:PANX1
uniprot id: M3W287
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9685:DPT
gene id: 9685:DPT
uniprot id: M3XE34
names: Similarity
messages: Belongs to the dermatopontin family.

9685:LOC493954
gene id: 9685:LOC493954
uniprot id: O46524
names: Similarity
messages: Belongs to the peptidase A1 family.

9685:GTF2H3
gene id: 9685:GTF2H3
uniprot id: M3W0X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9685:IL17B
gene id: 9685:IL17B
uniprot id: M3W0P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9685:VPS45
gene id: 9685:VPS45
uniprot id: M3WCQ2
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9685:DUSP16
gene id: 9685:DUSP16
uniprot id: M3WZQ1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9685:TMEM144
gene id: 9685:TMEM144
uniprot id: A0A5F5XVN0
uniprot id: M3VY65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9685:CFB
gene id: 9685:CFB
uniprot id: M3W2B8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:SLC17A3
gene id: 9685:SLC17A3
uniprot id: A0A2I2UCB9
uniprot id: A0A2I2UU43
names: Subcellular Location Annotation
messages: Membrane

9685:CALR3
gene id: 9685:CALR3
uniprot id: A0A2I2U8F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9685:FAM199X
gene id: 9685:FAM199X
uniprot id: M3W605
names: Similarity
messages: Belongs to the FAM199 family.

9685:GHRL
gene id: 9685:GHRL
uniprot id: Q6BEG6
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 2.5-fold increase in plasma level of ghrelin upon fasting.
messages: Amidation of Leu-98 is essential for obestatin activity.
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity).
messages: O-octanoylated by GOAT/MBOAT4 (By similarity). O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-27-C10:1, ghrelin-27-C10:2, ghrelin-28-C8:1, ghrelin-28-C10:1, and ghrelin-28-C10:2, may be modified with singly or doubly unsaturated carboxylic acids (PubMed:16466902).
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
messages: Secreted

9685:ART5
gene id: 9685:ART5
uniprot id: M3X2S2
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9685:RRAGA
gene id: 9685:RRAGA
uniprot id: M3X4R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9685:MCF2L
gene id: 9685:MCF2L
uniprot id: A0A2I2V4Y6
names: Subcellular Location Annotation
messages: Cytoplasm

9685:MICALL2
gene id: 9685:MICALL2
uniprot id: M3W826
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101081393
gene id: 9685:LOC101081393
uniprot id: M3XDF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CFAP298
gene id: 9685:CFAP298
uniprot id: M3X8G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9685:SQLE
gene id: 9685:SQLE
uniprot id: M3X722
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9685:LOC101098257
gene id: 9685:LOC101098257
uniprot id: A0A2I2UX44
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9685:P2RY1
gene id: 9685:P2RY1
uniprot id: M3WI21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:INTS14
gene id: 9685:INTS14
uniprot id: A0A2I2U2G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9685:CDSN
gene id: 9685:CDSN
uniprot id: M3X143
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9685:LOC101096566
gene id: 9685:LOC101096566
uniprot id: M3WL43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:RPRD1A
gene id: 9685:RPRD1A
uniprot id: A0A337SN10
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9685:GPRC5C
gene id: 9685:GPRC5C
uniprot id: A0A2I2UI30
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:ANAPC10
gene id: 9685:ANAPC10
uniprot id: M3WVJ2
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9685:EDC3
gene id: 9685:EDC3
uniprot id: A0A337SM77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9685:TACO1
gene id: 9685:TACO1
uniprot id: A0A2I2UQ26
names: Similarity
messages: Belongs to the TACO1 family.

9685:GNPAT
gene id: 9685:GNPAT
uniprot id: A0A2I2UWU0
uniprot id: A0A5F5XMU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9685:ATP5PO
gene id: 9685:ATP5PO
uniprot id: M3WSZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9685:DPF3
gene id: 9685:DPF3
uniprot id: M3WL59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the requiem/DPF family.
messages: Nucleus

9685:FLOT1
gene id: 9685:FLOT1
uniprot id: M3W869
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: Membrane
messages: caveola

9685:SLC20A2
gene id: 9685:SLC20A2
uniprot id: A0A0A0MQ00
uniprot id: Q95L97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.
messages: Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage calcification and vascular calcification (By similarity). Functions as a retroviral receptor for feline leukemia virus subgroup B (FeLV-B).

9685:CFAP36
gene id: 9685:CFAP36
uniprot id: M3W0H8
names: Similarity
messages: Belongs to the CFAP36 family.

9685:TUBGCP5
gene id: 9685:TUBGCP5
uniprot id: A0A2I2UE95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9685:ABAT
gene id: 9685:ABAT
uniprot id: M3WQN5
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9685:PSENEN
gene id: 9685:PSENEN
uniprot id: M3WRU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9685:HARBI1
gene id: 9685:HARBI1
uniprot id: M3WSI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9685:BANF2
gene id: 9685:BANF2
uniprot id: A0A2I2UDG2
names: Subcellular Location Annotation
messages: Nucleus

9685:ARL4D
gene id: 9685:ARL4D
uniprot id: M3XEK4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9685:CLRN2
gene id: 9685:CLRN2
uniprot id: M3VZ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9685:CCT6B
gene id: 9685:CCT6B
uniprot id: A0A337S679
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9685:CD82
gene id: 9685:CD82
uniprot id: M3WHR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:ELL3
gene id: 9685:ELL3
uniprot id: M3W669
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9685:GOT2
gene id: 9685:GOT2
uniprot id: M3XE42
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9685:LOC101081755
gene id: 9685:LOC101081755
uniprot id: M3X4M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PARG
gene id: 9685:PARG
uniprot id: M3WEE8
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9685:FGFR2
gene id: 9685:FGFR2
uniprot id: A0A5F5Y2A8
uniprot id: A0A5F5Y433
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9685:DSC1
gene id: 9685:DSC1
uniprot id: A0A2I2UZT4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9685:LOC105260533
gene id: 9685:LOC105260533
uniprot id: A0A2I2UQ24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:HTR1B
gene id: 9685:HTR1B
uniprot id: Q588Y6
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).
messages: Homodimer. Heterodimer with HTR1D (By similarity).
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Palmitoylated.
messages: Phosphorylated.

9685:SPTAN1
gene id: 9685:SPTAN1
uniprot id: A0A2I2UU45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9685:IRF9
gene id: 9685:IRF9
uniprot id: M3WNI8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:BATF
gene id: 9685:BATF
uniprot id: A0A2I2UY30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9685:BCL2L1
gene id: 9685:BCL2L1
uniprot id: Q8SQ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9685:CHST12
gene id: 9685:CHST12
uniprot id: A0A5F5XE15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:RAB3IL1
gene id: 9685:RAB3IL1
uniprot id: A0A2I2V0V8
uniprot id: A0A5F5XW62
names: Similarity
messages: Belongs to the SEC2 family.

9685:PPM1A
gene id: 9685:PPM1A
uniprot id: A0A337SV75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9685:CEP19
gene id: 9685:CEP19
uniprot id: A0A337SIL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9685:TRDMT1
gene id: 9685:TRDMT1
uniprot id: A0A2I2UB83
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9685:PRKCH
gene id: 9685:PRKCH
uniprot id: M3WHU4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9685:PIPOX
gene id: 9685:PIPOX
uniprot id: M3W6Z7
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9685:GPR87
gene id: 9685:GPR87
uniprot id: M3WD71
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:AMIGO1
gene id: 9685:AMIGO1
uniprot id: M3WMW5
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9685:EFNA5
gene id: 9685:EFNA5
uniprot id: A0A337S0H8
uniprot id: A0A337SUS6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:NR3C1
gene id: 9685:NR3C1
uniprot id: A0A0A1GK17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

9685:LOC101101667
gene id: 9685:LOC101101667
uniprot id: M3WW05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SEC31A
gene id: 9685:SEC31A
uniprot id: A0A2I2UE80
uniprot id: A0A2I2V4B0
uniprot id: A0A337SWZ3
uniprot id: M3VWV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:WDR48
gene id: 9685:WDR48
uniprot id: M3X587
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Endosome
messages: Late endosome

9685:GALNT17
gene id: 9685:GALNT17
uniprot id: M3WMF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9685:LDAF1
gene id: 9685:LDAF1
uniprot id: A0A2I2V4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9685:BCS1L
gene id: 9685:BCS1L
uniprot id: M3W1N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9685:SLC30A4
gene id: 9685:SLC30A4
uniprot id: M3XB76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9685:FGF16
gene id: 9685:FGF16
uniprot id: M3WSS3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9685:JUP
gene id: 9685:JUP
uniprot id: A0A2I2UBN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
messages: Membrane
messages: adherens junction
messages: desmosome

9685:PIGG
gene id: 9685:PIGG
uniprot id: M3W965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:SLC26A7
gene id: 9685:SLC26A7
uniprot id: M3WA61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9685:GABARAPL2
gene id: 9685:GABARAPL2
uniprot id: M3W9J5
names: Similarity
messages: Belongs to the ATG8 family.

9685:ADCYAP1
gene id: 9685:ADCYAP1
uniprot id: A0A2I2U6R5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucagon family.
messages: Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
messages: Secreted

9685:ATP2A2
gene id: 9685:ATP2A2
uniprot id: Q00779
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation.
messages: Endoplasmic reticulum membrane
messages: Has different conformational states with differential Ca2+ affinity. The E1 conformational state (active form) shows high Ca(2+) affinity, while the E2 state exhibits low Ca(2+) affinity. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Inhibited by sarcolipin (SLN) and myoregulin (MRLN). The inhibition is blocked by VMP1 (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Stabilizes SERCA2 in its E2 state (By similarity).
messages: Interacts with TRAM2 (via C-terminus).
messages: Interacts with sarcolipin (SLN); the interaction inhibits ATP2A2 Ca(2+) affinity. Interacts with phospholamban (PLN); the interaction inhibits ATP2A2 Ca(2+) affinity (By similarity). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Interacts with HAX1 (By similarity). Interacts with S100A8 and S100A9 (By similarity). Interacts with SLC35G1 and STIM1. Interacts with TMEM203 (By similarity). Interacts with TMEM64 and PDIA3 (By similarity). Interacts with TMX2 (By similarity). Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with ULK1 (By similarity). Interacts with S100A1 in a Ca(2+)-dependent manner (By similarity). Interacts with TUNAR (By similarity).
messages: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation.
messages: Isoform 1 is expressed in the heart.
messages: Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity.
messages: PLN and SLN both have a single transmembrane helix; both occupy a similar binding site that is situated between the ATP2A2 transmembrane helices.
messages: Sarcoplasmic reticulum membrane
messages: Serotonylated on Gln residues by TGM2 in response to hypoxia, leading to its inactivation.
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes.

9685:WNT2
gene id: 9685:WNT2
uniprot id: A0M8T2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

9685:TLX3
gene id: 9685:TLX3
uniprot id: A0A2I2V1A4
names: Subcellular Location Annotation
messages: Nucleus

9685:FAM98A
gene id: 9685:FAM98A
uniprot id: M3WUT2
names: Similarity
messages: Belongs to the FAM98 family.

9685:MLEC
gene id: 9685:MLEC
uniprot id: M3VYF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:TOX4
gene id: 9685:TOX4
uniprot id: A0A2I2UFD6
names: Subcellular Location Annotation
messages: Nucleus

9685:HMGB1
gene id: 9685:HMGB1
uniprot id: M3VUA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Secreted

9685:MED27
gene id: 9685:MED27
uniprot id: A0A337SIV1
uniprot id: A0A5F5XIS7
uniprot id: A0A5F5XTF9
uniprot id: M3W738
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9685:NFS1
gene id: 9685:NFS1
uniprot id: A0A337SAK4
uniprot id: M3VZZ3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9685:LOC101090225
gene id: 9685:LOC101090225
uniprot id: M3WN96
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9685:MDM2
gene id: 9685:MDM2
uniprot id: A0A2I2U893
uniprot id: Q7YRZ8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitination leads to proteasomal degradation; resulting in p53/TP53 activation it may be regulated by SFN. Also ubiquitinated by TRIM13. Deubiquitinated by USP2 leads to its accumulation and increases deubiquitination and degradation of p53/TP53. Deubiquitinated by USP7 leading to its stabilization.
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells. Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity).
messages: Interacts with p53/TP53, TP73/p73, RBL5 and RP11. Binds specifically to RNA. Can interact with RB1, E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with p53/TP53 and WWOX. Interacts with CDKN2AIP, RFWD3, USP7, PYHIN1 and RBBP6. Interacts with ARRB1 and ARRB2. Interacts with PSMA3. Found in a trimeric complex with MDM2, MDM4 and USP2. Interacts with USP2 (via N-terminus and C-terminus). Interacts with MDM4. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts directly with DAXX and USP7. Interacts (via C-terminus) with RASSF1 isoform A (via N-terminus); the interaction is independent of TP53. Interacts with APEX1; leading to its ubiquitination and degradation. Interacts with RYBP; this inhibits ubiquitination of TP53. Identified in a complex with RYBP and p53/TP53. Also a component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in regulating p53/TP53 stabilization and activity. Binds directly both p53/TP53 and TRIM28. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses with DNA damage. Interacts directly with both TRIM28 and ERBB4 in the complex. Interacts with DYRK2. Interacts with IGF1R. Interacts with TRIM13; the interaction ubiquitinates MDM2 leading to its proteasomal degradation. Interacts with SNAI1; this interaction promotes SNAI1 ubiquitination. Interacts with NOTCH1 (via intracellular domain). Interacts with FHIT. Interacts with RFFL and RNF34; the interaction stabilizes MDM2. Interacts with CDK5RAP3 and CDKN2A/ARF; form a ternary complex involved in regulation of p53/TP53. Interacts with MTA1. Interacts with AARB2. Interacts with MTBP. Interacts with PML. Interacts with RPL11. Interacts with TBRG1. Interacts with the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11; the interaction is direct occurs in the nucleoplasm and negatively regulates MDM2-mediated TP53 ubiquitination and degradation. Interacts with ADGRB1;…
messages: Nucleus
messages: Phosphorylation on Ser-166 by SGK1 activates ubiquitination of p53/TP53. Phosphorylated at multiple sites near the RING domain by ATM upon DNA damage; this prevents oligomerization and E3 ligase processivity and impedes constitutive p53/TP53 degradation (By similarity).
messages: Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself (By similarity).
messages: nucleolus
messages: nucleoplasm

9685:POLR3A
gene id: 9685:POLR3A
uniprot id: M3VVI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9685:TUBGCP4
gene id: 9685:TUBGCP4
uniprot id: M3XDN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9685:LOC101085685
gene id: 9685:LOC101085685
uniprot id: M3W1S2
names: Similarity
messages: Belongs to the BIVM family.

9685:LOC101080897
gene id: 9685:LOC101080897
uniprot id: M3WCX1
names: Similarity
messages: Belongs to the serpin family.

9685:CLEC16A
gene id: 9685:CLEC16A
uniprot id: M3WFI8
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9685:LOC101095695
gene id: 9685:LOC101095695
uniprot id: A0A2I2UBC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SMIM7
gene id: 9685:SMIM7
uniprot id: A0A337SU07
names: Similarity
messages: Belongs to the SMIM7 family.

9685:SLC8A1
gene id: 9685:SLC8A1
uniprot id: P48767
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by micromolar levels of Ca(2+).
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Detected in heart (at protein level). Detected in heart.
messages: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
messages: The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.

9685:GDF9
gene id: 9685:GDF9
uniprot id: C7EWM1
uniprot id: M3WGX0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9685:CYP27B1
gene id: 9685:CYP27B1
uniprot id: M3WL64
names: Similarity
messages: Belongs to the cytochrome P450 family.

9685:CLK4
gene id: 9685:CLK4
uniprot id: M3WQC0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:FHIP1A
gene id: 9685:FHIP1A
uniprot id: M3X351
names: Similarity
messages: Belongs to the FHIP family.

9685:INTS12
gene id: 9685:INTS12
uniprot id: M3WSY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9685:LOC101093877
gene id: 9685:LOC101093877
uniprot id: M3WX35
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9685:CALB1
gene id: 9685:CALB1
uniprot id: A0A337RZZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

9685:PRPH2
gene id: 9685:PRPH2
uniprot id: P35906
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PRPH2/ROM1 family.
messages: Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Forms a homotetramer (By similarity). Forms a heterotetramer with ROM1 (By similarity). Homotetramer and heterotetramer core complexes go on to form higher order complexes by formation of intermolecular disulfide bonds (By similarity). Interacts with MREG (By similarity). Interacts with STX3 (By similarity). Interacts with SNAP25 (By similarity).
messages: Membrane
messages: Photoreceptor inner segment
messages: Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.
messages: photoreceptor outer segment

9685:SLC9A9
gene id: 9685:SLC9A9
uniprot id: A0A5F5XFX9
uniprot id: A0A5F5XRV7
uniprot id: M3WB66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9685:SLC46A1
gene id: 9685:SLC46A1
uniprot id: M3W9I8
names: Subcellular Location Annotation
messages: Membrane

9685:ZNF202
gene id: 9685:ZNF202
uniprot id: A0A2I2UEW4
names: Subcellular Location Annotation
messages: Nucleus

9685:MRPL50
gene id: 9685:MRPL50
uniprot id: M3WTK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9685:DENND5B
gene id: 9685:DENND5B
uniprot id: A0A2I2UXB5
uniprot id: M3W481
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:MCOLN1
gene id: 9685:MCOLN1
uniprot id: M3W9B1
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9685:STAMBPL1
gene id: 9685:STAMBPL1
uniprot id: A0A2I2V4S8
names: Similarity
messages: Belongs to the peptidase M67C family.

9685:POLL
gene id: 9685:POLL
uniprot id: M3WN40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9685:IL19
gene id: 9685:IL19
uniprot id: M3W5Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9685:CA3
gene id: 9685:CA3
uniprot id: M3WS40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9685:SLC39A8
gene id: 9685:SLC39A8
uniprot id: M3WFU4
names: Subcellular Location Annotation
messages: Membrane

9685:ATP5MG
gene id: 9685:ATP5MG
uniprot id: A0A337SSK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9685:SLC4A2
gene id: 9685:SLC4A2
uniprot id: A0A337SQX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane
messages: Plasma membrane anion exchange protein of wide distribution.

9685:STX19
gene id: 9685:STX19
uniprot id: A0A2I2UVU9
names: Similarity
messages: Belongs to the syntaxin family.

9685:CAP2
gene id: 9685:CAP2
uniprot id: A0A2I2U916
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane

9685:CHRM2
gene id: 9685:CHRM2
uniprot id: M3WSG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9685:PSMB6
gene id: 9685:PSMB6
uniprot id: A0A2I2U3F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9685:CDC42SE2
gene id: 9685:CDC42SE2
uniprot id: A0A2I2UVE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9685:SLC35C1
gene id: 9685:SLC35C1
uniprot id: M3WYQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

9685:ODF2L
gene id: 9685:ODF2L
uniprot id: M3WPF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9685:ABHD2
gene id: 9685:ABHD2
uniprot id: M3WHT2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9685:LOC101096016
gene id: 9685:LOC101096016
uniprot id: M3WHJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:AWAT1
gene id: 9685:AWAT1
uniprot id: A0A2I2UB18
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:GDAP1L1
gene id: 9685:GDAP1L1
uniprot id: M3W938
names: Similarity
messages: Belongs to the GST superfamily.

9685:NLGN1
gene id: 9685:NLGN1
uniprot id: M3WA79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9685:CDH7
gene id: 9685:CDH7
uniprot id: A0A5F5XHD2
uniprot id: M3WP22
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9685:APIP
gene id: 9685:APIP
uniprot id: M3VYQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9685:RBM3
gene id: 9685:RBM3
uniprot id: M3VY54
names: Subcellular Location Annotation
messages: Cytoplasm

9685:SLC6A12
gene id: 9685:SLC6A12
uniprot id: M3X4J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Interacts with LIN7C.
messages: Membrane
messages: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.

9685:PEX5
gene id: 9685:PEX5
uniprot id: M3VU88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
messages: Cytoplasm
messages: Membrane

9685:PISD
gene id: 9685:PISD
uniprot id: A0A2I2UM52
uniprot id: A0A5F5Y004
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9685:LOC101082481
gene id: 9685:LOC101082481
uniprot id: M3XFU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GPKOW
gene id: 9685:GPKOW
uniprot id: M3W112
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus

9685:ZPBP2
gene id: 9685:ZPBP2
uniprot id: M3X8S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

9685:AP5M1
gene id: 9685:AP5M1
uniprot id: A0A337S9S7
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9685:BET1L
gene id: 9685:BET1L
uniprot id: A0A2I2U3S6
names: Subcellular Location Annotation
messages: Membrane

9685:MAB21L2
gene id: 9685:MAB21L2
uniprot id: M3X8D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

9685:INHBE
gene id: 9685:INHBE
uniprot id: M3VZY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9685:HUS1
gene id: 9685:HUS1
uniprot id: M3XC14
names: Similarity
messages: Belongs to the HUS1 family.

9685:PDE7B
gene id: 9685:PDE7B
uniprot id: A0A2I2UG14
uniprot id: A0A337S7F9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9685:CS
gene id: 9685:CS
uniprot id: M3WG68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

9685:CRAT
gene id: 9685:CRAT
uniprot id: A0A2I2UP24
uniprot id: A0A5F5Y5C0
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9685:LOC101088763
gene id: 9685:LOC101088763
uniprot id: A0A2I2UGG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ASF1B
gene id: 9685:ASF1B
uniprot id: M3X9K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9685:DUOXA1
gene id: 9685:DUOXA1
uniprot id: A0A2I2UYK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9685:RTCB
gene id: 9685:RTCB
uniprot id: M3XE87
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9685:TATDN3
gene id: 9685:TATDN3
uniprot id: A0A337SLJ7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9685:TUBA8
gene id: 9685:TUBA8
uniprot id: M3WCF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9685:MAT2B
gene id: 9685:MAT2B
uniprot id: A0A2I2U4K6
uniprot id: A0A337S783
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9685:ING4
gene id: 9685:ING4
uniprot id: A0A2I2U6Q5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9685:RPL36
gene id: 9685:RPL36
uniprot id: M3WFV3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9685:VGLL4
gene id: 9685:VGLL4
uniprot id: A0A337S3N4
uniprot id: A0A337SFM6
uniprot id: M3W017
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9685:GHITM
gene id: 9685:GHITM
uniprot id: M3VX10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9685:PLK1
gene id: 9685:PLK1
uniprot id: M3WHX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

9685:EIF1
gene id: 9685:EIF1
uniprot id: A0A2I2UEV3
names: Similarity
messages: Belongs to the SUI1 family.

9685:TRIM9
gene id: 9685:TRIM9
uniprot id: A0A2I2V2B5
uniprot id: M3VZ46
names: Subcellular Location Annotation
messages: cytoskeleton

9685:CNOT3
gene id: 9685:CNOT3
uniprot id: M3WJZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
messages: Nucleus
messages: P-body

9685:LOC101099090
gene id: 9685:LOC101099090
uniprot id: M3WFJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9685:MAN1C1
gene id: 9685:MAN1C1
uniprot id: M3WHL7
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9685:AIFM1
gene id: 9685:AIFM1
uniprot id: A0A337SKT2
uniprot id: M3W9M2
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9685:KCNC1
gene id: 9685:KCNC1
uniprot id: M3W381
names: Subcellular Location Annotation
messages: Membrane

9685:LUC7L3
gene id: 9685:LUC7L3
uniprot id: A0A5F5Y6A9
uniprot id: M3WGR7
names: Similarity
messages: Belongs to the Luc7 family.

9685:ERMN
gene id: 9685:ERMN
uniprot id: A0A2I2UX21
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9685:RNASE10
gene id: 9685:RNASE10
uniprot id: M3W6S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9685:SGCZ
gene id: 9685:SGCZ
uniprot id: M3XFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9685:SLC35F1
gene id: 9685:SLC35F1
uniprot id: M3XBA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9685:FBLN5
gene id: 9685:FBLN5
uniprot id: M3WFS9
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:KCNJ3
gene id: 9685:KCNJ3
uniprot id: M3XFS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9685:PARVB
gene id: 9685:PARVB
uniprot id: M3XDD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9685:LETM2
gene id: 9685:LETM2
uniprot id: M3WJ60
names: Subcellular Location Annotation
messages: Membrane

9685:PDE7A
gene id: 9685:PDE7A
uniprot id: A0A2I2U050
uniprot id: M3VXT4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9685:ADGRV1
gene id: 9685:ADGRV1
uniprot id: M3WGV7
names: Subcellular Location Annotation
messages: Membrane

9685:POU2F1
gene id: 9685:POU2F1
uniprot id: A0A337SFE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9685:ATP6V1B2
gene id: 9685:ATP6V1B2
uniprot id: M3WIR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9685:NAPA
gene id: 9685:NAPA
uniprot id: M3W5E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9685:RRAGD
gene id: 9685:RRAGD
uniprot id: M3X3N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9685:CLIC5
gene id: 9685:CLIC5
uniprot id: A0A2I2UVX8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9685:GUCY2C
gene id: 9685:GUCY2C
uniprot id: A0A2I2U408
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9685:TET3
gene id: 9685:TET3
uniprot id: A0A2I2UYM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9685:AKR1D1
gene id: 9685:AKR1D1
uniprot id: M3W615
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9685:LOC101085786
gene id: 9685:LOC101085786
uniprot id: A0A2I2U0I5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.

9685:CDK5RAP3
gene id: 9685:CDK5RAP3
uniprot id: M3WBA5
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9685:MED22
gene id: 9685:MED22
uniprot id: M3W4S0
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9685:NIT1
gene id: 9685:NIT1
uniprot id: A0A337SSX6
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9685:GRHL3
gene id: 9685:GRHL3
uniprot id: M3WPH1
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101101118
gene id: 9685:LOC101101118
uniprot id: A0A337SC15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

9685:ALOXE3
gene id: 9685:ALOXE3
uniprot id: M3WM46
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:DHRS7
gene id: 9685:DHRS7
uniprot id: M3WDG4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:PAN2
gene id: 9685:PAN2
uniprot id: M3WG70
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9685:UCN3
gene id: 9685:UCN3
uniprot id: A0A5F5Y6R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9685:GPR132
gene id: 9685:GPR132
uniprot id: A0A337SI48
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:LGMN
gene id: 9685:LGMN
uniprot id: M3W8K5
names: Similarity
messages: Belongs to the peptidase C13 family.

9685:TMEM178B
gene id: 9685:TMEM178B
uniprot id: A0A337SJL4
names: Similarity
messages: Belongs to the TMEM178 family.

9685:SMIM18
gene id: 9685:SMIM18
uniprot id: M3WVL0
names: Subcellular Location Annotation
messages: Membrane

9685:F13A1
gene id: 9685:F13A1
uniprot id: M3WMR4
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9685:MMP1
gene id: 9685:MMP1
uniprot id: M3WNA1
names: Similarity
messages: Belongs to the peptidase M10A family.

9685:EIF2B4
gene id: 9685:EIF2B4
uniprot id: A0A337S5G6
uniprot id: M3WM19
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9685:LMLN
gene id: 9685:LMLN
uniprot id: A0A337SKC2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

9685:NRP1
gene id: 9685:NRP1
uniprot id: M3W5I5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:ATP7B
gene id: 9685:ATP7B
uniprot id: A0A5F5XXB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9685:ATP6V0A1
gene id: 9685:ATP6V0A1
uniprot id: A0A2I2UQR5
uniprot id: A0A2I2V1Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9685:UQCC1
gene id: 9685:UQCC1
uniprot id: A0A2I2UPT8
uniprot id: A0A337SFX7
names: Similarity
messages: Belongs to the CBP3 family.

9685:LDLRAD4
gene id: 9685:LDLRAD4
uniprot id: A0A2I2UBM6
uniprot id: M3X8V0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:SDHC
gene id: 9685:SDHC
uniprot id: M3VUW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9685:COQ10A
gene id: 9685:COQ10A
uniprot id: M3WG67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9685:MOK
gene id: 9685:MOK
uniprot id: A0A337SR62
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:ST8SIA5
gene id: 9685:ST8SIA5
uniprot id: A0A2I2U4C2
uniprot id: M3VZ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9685:HEXB
gene id: 9685:HEXB
uniprot id: P49614
names: Activity Regulation
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Addition of GM2A stimulates the hydrolysis of sulfated glycosphingolipid SM2 and the ganglioside GM2.
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Cortical granule
messages: Defects in HEXB are responsible for Sandhoff disease (GM2-gangliosidosis type-II). This disorder is found in Korat cats (initially imported from Thailand).
messages: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity).
messages: Lysosome
messages: There are 3 forms of beta-hexosaminidase: hexosaminidase A is an heterodimer composed of one subunit alpha and one subunit beta (chain A and B); hexosaminidase B is an homodimer of two beta subunits (two chains A and B); hexosaminidase S is a homodimer of two alpha subunits (By similarity). The composition of the dimer (isozyme A versus isozyme S) has a significant effect on the substrate specificity of the alpha subunit active site (By similarity).

9685:CDS2
gene id: 9685:CDS2
uniprot id: A0A5F5XTP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9685:STXBP3
gene id: 9685:STXBP3
uniprot id: M3WQB8
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9685:MSMP
gene id: 9685:MSMP
uniprot id: M3WPH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9685:LHB
gene id: 9685:LHB
uniprot id: O77805
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
messages: Secreted

9685:MDM1
gene id: 9685:MDM1
uniprot id: A0A337SSU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9685:PPP1R11
gene id: 9685:PPP1R11
uniprot id: A0A2I2UM79
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9685:LOC102899183
gene id: 9685:LOC102899183
uniprot id: A0A2I2UAC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9685:PARP6
gene id: 9685:PARP6
uniprot id: A0A337S4I7
uniprot id: M3WYA9
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Belongs to the pyruvate kinase family.

9685:PNKD
gene id: 9685:PNKD
uniprot id: A0A5F5XE86
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9685:ABCB6
gene id: 9685:ABCB6
uniprot id: M3WEQ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: extracellular exosome
messages: multivesicular body membrane

9685:ATG4C
gene id: 9685:ATG4C
uniprot id: A0A2I2UM47
uniprot id: M3XAC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9685:LOC101083056
gene id: 9685:LOC101083056
uniprot id: M3X296
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CAMK2D
gene id: 9685:CAMK2D
uniprot id: A0A2I2UCF5
uniprot id: A0A337S4F5
uniprot id: A0A337SMM9
uniprot id: A0A5F5XU46
uniprot id: A0A5F5Y385
uniprot id: M3WNF0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9685:DGAT1
gene id: 9685:DGAT1
uniprot id: M3W886
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9685:B3GNT8
gene id: 9685:B3GNT8
uniprot id: M3W424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:SNAPC3
gene id: 9685:SNAPC3
uniprot id: M3VZV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

9685:ESYT3
gene id: 9685:ESYT3
uniprot id: M3WI11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:GUCY1A1
gene id: 9685:GUCY1A1
uniprot id: A0A2I2V1M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9685:SPARC
gene id: 9685:SPARC
uniprot id: M3W550
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

9685:MAP7D2
gene id: 9685:MAP7D2
uniprot id: A0A2I2U5N3
uniprot id: A0A337SBP6
uniprot id: A0A337SNL7
uniprot id: M3WDY0
names: Similarity
messages: Belongs to the MAP7 family.

9685:LOC101099773
gene id: 9685:LOC101099773
uniprot id: M3WI84
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9685:YARS2
gene id: 9685:YARS2
uniprot id: M3W3W2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9685:INTS8
gene id: 9685:INTS8
uniprot id: M3W5A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9685:GOSR1
gene id: 9685:GOSR1
uniprot id: A0A2I2U368
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9685:CASR
gene id: 9685:CASR
uniprot id: C7FF08
uniprot id: M3WA39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:TRAF1
gene id: 9685:TRAF1
uniprot id: M3X9B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9685:SLC52A3
gene id: 9685:SLC52A3
uniprot id: M3WE72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9685:POU4F2
gene id: 9685:POU4F2
uniprot id: M3VZM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9685:ERO1B
gene id: 9685:ERO1B
uniprot id: M3W090
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9685:PTGES3
gene id: 9685:PTGES3
uniprot id: A0A2I2UJD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9685:SLC17A1
gene id: 9685:SLC17A1
uniprot id: M3WL45
names: Subcellular Location Annotation
messages: Membrane

9685:ZHX3
gene id: 9685:ZHX3
uniprot id: M3WAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9685:LOC101083444
gene id: 9685:LOC101083444
uniprot id: M3WJY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9685:BECN1
gene id: 9685:BECN1
uniprot id: M3WIA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9685:MAPT
gene id: 9685:MAPT
uniprot id: A0A337S3K6
uniprot id: A0A337S885
uniprot id: A0A337SDC9
uniprot id: A0A337SDL5
uniprot id: M3W6D2
names: Subcellular Location Annotation
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol

9685:KCNE1
gene id: 9685:KCNE1
uniprot id: Q9XSP1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
messages: Apical cell membrane
messages: Belongs to the potassium channel KCNE family.
messages: Cell membrane
messages: Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex KCNQ1-KCNE1 to the membrane raft (By similarity).
messages: Membrane raft
messages: N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.
messages: Phosphorylation inhibits the potassium current.

9685:SPRING1
gene id: 9685:SPRING1
uniprot id: M3VVT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

9685:SLC2A3
gene id: 9685:SLC2A3
uniprot id: A0A2I2UUL1
uniprot id: A0A5F5XSG5
uniprot id: M3VWZ7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9685:CYFIP2
gene id: 9685:CYFIP2
uniprot id: A0A2I2U7Z7
names: Similarity
messages: Belongs to the CYFIP family.

9685:MRPL58
gene id: 9685:MRPL58
uniprot id: A0A2I2U715
names: Subcellular Location Annotation
messages: Mitochondrion

9685:PALS2
gene id: 9685:PALS2
uniprot id: A0A337S363
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9685:PYROXD1
gene id: 9685:PYROXD1
uniprot id: M3WHX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9685:LLGL1
gene id: 9685:LLGL1
uniprot id: M3WMK1
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

9685:MPPE1
gene id: 9685:MPPE1
uniprot id: A0A2I2UL78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9685:MAP3K12
gene id: 9685:MAP3K12
uniprot id: M3WHK7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9685:FBXO9
gene id: 9685:FBXO9
uniprot id: M3WWA9
names: Subcellular Location Annotation
messages: Cytoplasm

9685:ITGB8
gene id: 9685:ITGB8
uniprot id: M3W6P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9685:AOC2
gene id: 9685:AOC2
uniprot id: A0A2I2U0U5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9685:TBCE
gene id: 9685:TBCE
uniprot id: A0A5F5XUB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

9685:LIPT1
gene id: 9685:LIPT1
uniprot id: A0A2I2U9H5
names: Similarity
messages: Belongs to the LplA family.

9685:KCNJ4
gene id: 9685:KCNJ4
uniprot id: A0A5F5Y050
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9685:HNF1B
gene id: 9685:HNF1B
uniprot id: A0A2I2UV93
uniprot id: M3VUC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9685:CDK3
gene id: 9685:CDK3
uniprot id: M3W4N5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:LOC101090164
gene id: 9685:LOC101090164
uniprot id: A0A2I2UKK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:BRMS1L
gene id: 9685:BRMS1L
uniprot id: M3WQI1
names: Subcellular Location Annotation
messages: Nucleus

9685:STARD8
gene id: 9685:STARD8
uniprot id: A0A5F5Y6F4
names: Subcellular Location Annotation
messages: Cytoplasm

9685:LOC109498222
gene id: 9685:LOC109498222
uniprot id: A0A2I2U557
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:MED20
gene id: 9685:MED20
uniprot id: M3XB75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9685:TM7SF3
gene id: 9685:TM7SF3
uniprot id: M3XFJ6
names: Subcellular Location Annotation
messages: Membrane

9685:RSPO3
gene id: 9685:RSPO3
uniprot id: M3WAW8
names: Similarity
messages: Belongs to the R-spondin family.

9685:CCDC86
gene id: 9685:CCDC86
uniprot id: M3WJ95
names: Subcellular Location Annotation
messages: Nucleus

9685:ABHD16A
gene id: 9685:ABHD16A
uniprot id: M3W2B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

9685:LOC101093286
gene id: 9685:LOC101093286
uniprot id: A0A337S8Q9
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9685:ALDOB
gene id: 9685:ALDOB
uniprot id: M3VWL2
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9685:PLAA
gene id: 9685:PLAA
uniprot id: M3XEX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9685:GJB3
gene id: 9685:GJB3
uniprot id: A0A654IEE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:IL12A
gene id: 9685:IL12A
uniprot id: O02743
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12. Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
messages: Secreted

9685:OAS1
gene id: 9685:OAS1
uniprot id: M3VUI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9685:LMX1B
gene id: 9685:LMX1B
uniprot id: M3VWN9
names: Subcellular Location Annotation
messages: Nucleus

9685:ITIH5
gene id: 9685:ITIH5
uniprot id: M3WEM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9685:TOMM20
gene id: 9685:TOMM20
uniprot id: M3X685
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9685:CC1H2orf88
gene id: 9685:CC1H2orf88
uniprot id: M3X8X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9685:FBXO45
gene id: 9685:FBXO45
uniprot id: A0A2I2UCE9
names: Similarity
messages: Belongs to the FBXO45/Fsn family.

9685:USP5
gene id: 9685:USP5
uniprot id: M3W1X0
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9685:LOC101100855
gene id: 9685:LOC101100855
uniprot id: A0A2I2UFI3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:RXRA
gene id: 9685:RXRA
uniprot id: A0A2I2U0T0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9685:FGD2
gene id: 9685:FGD2
uniprot id: A0A2I2U4C3
names: Subcellular Location Annotation
messages: cytoskeleton

9685:FAM13A
gene id: 9685:FAM13A
uniprot id: A0A2I2UM86
uniprot id: A0A2I2UV00
uniprot id: M3WMQ8
names: Similarity
messages: Belongs to the FAM13 family.

9685:PGK1
gene id: 9685:PGK1
uniprot id: A0A2I2UJH0
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9685:GNPDA1
gene id: 9685:GNPDA1
uniprot id: M3WBD4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9685:APOO
gene id: 9685:APOO
uniprot id: M3VTY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9685:GAB1
gene id: 9685:GAB1
uniprot id: A0A2I2U3H6
uniprot id: A0A2I2UZ86
uniprot id: M3X119
names: Similarity
messages: Belongs to the GAB family.

9685:UBA2
gene id: 9685:UBA2
uniprot id: M3X2D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

9685:RRH
gene id: 9685:RRH
uniprot id: M3W437
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9685:NRN1L
gene id: 9685:NRN1L
uniprot id: M3X283
names: Similarity
messages: Belongs to the neuritin family.

9685:CYGB
gene id: 9685:CYGB
uniprot id: M3W436
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.

9685:LOC101083026
gene id: 9685:LOC101083026
uniprot id: M3XBD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RPL8
gene id: 9685:RPL8
uniprot id: M3WRT2
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9685:TONSL
gene id: 9685:TONSL
uniprot id: M3WKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

9685:GRHPR
gene id: 9685:GRHPR
uniprot id: A0A5F5XTU8
uniprot id: M3WI68
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9685:SOAT1
gene id: 9685:SOAT1
uniprot id: M3W8J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:CYP3A132
gene id: 9685:CYP3A132
uniprot id: A0A5F5XIP0
uniprot id: F8WKX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9685:LOC101098159
gene id: 9685:LOC101098159
uniprot id: A0A2I2UXL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9685:LOC101081211
gene id: 9685:LOC101081211
uniprot id: M3WXK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:EML1
gene id: 9685:EML1
uniprot id: M3W2K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9685:RNGTT
gene id: 9685:RNGTT
uniprot id: M3WWR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9685:OTUB2
gene id: 9685:OTUB2
uniprot id: A0A2I2UUR0
names: Similarity
messages: Belongs to the peptidase C65 family.

9685:SERBP1
gene id: 9685:SERBP1
uniprot id: M3VV33
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9685:NDUFA2
gene id: 9685:NDUFA2
uniprot id: M3VWC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9685:EARS2
gene id: 9685:EARS2
uniprot id: M3X6Q0
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9685:SGIP1
gene id: 9685:SGIP1
uniprot id: A0A337SE53
uniprot id: A0A337SME5
names: Function
names: Subcellular Location Annotation
messages: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
messages: clathrin-coated pit

9685:MED25
gene id: 9685:MED25
uniprot id: A0A2I2U1I3
uniprot id: A0A5F5Y0E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 25 family.
messages: Nucleus

9685:PRKCE
gene id: 9685:PRKCE
uniprot id: A0A2I2USU9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

9685:LOC102899273
gene id: 9685:LOC102899273
uniprot id: A0A5F5XR40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CACNB1
gene id: 9685:CACNB1
uniprot id: A0A5F5XGW6
uniprot id: M3WCG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Membrane
messages: sarcolemma

9685:PLAU
gene id: 9685:PLAU
uniprot id: M3WMV1
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9685:IQCG
gene id: 9685:IQCG
uniprot id: M3WNK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9685:IL1RL1
gene id: 9685:IL1RL1
uniprot id: M3WRI0
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9685:SGK2
gene id: 9685:SGK2
uniprot id: M3VXG0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:ATXN1L
gene id: 9685:ATXN1L
uniprot id: A0A2I2UDK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9685:ST14
gene id: 9685:ST14
uniprot id: M3WBJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Degrades extracellular matrix.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:LOC101097669
gene id: 9685:LOC101097669
uniprot id: A0A5F5XZC2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:P2RX5
gene id: 9685:P2RX5
uniprot id: A0A5F5Y580
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9685:RSL24D1
gene id: 9685:RSL24D1
uniprot id: A0A2I2U291
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9685:EML2
gene id: 9685:EML2
uniprot id: M3W7J1
uniprot id: M3X7H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9685:ADAM2
gene id: 9685:ADAM2
uniprot id: A0A5F5XHG7
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with ADAM1/fertilin subunit alpha.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

9685:LGALS3
gene id: 9685:LGALS3
uniprot id: A0A337S4Q5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9685:CD3D
gene id: 9685:CD3D
uniprot id: A0A337SNX2
uniprot id: M3WFR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:MIGA2
gene id: 9685:MIGA2
uniprot id: M3W4V9
names: Similarity
messages: Belongs to the mitoguardin family.

9685:HPF1
gene id: 9685:HPF1
uniprot id: M3X8Z5
names: Similarity
messages: Belongs to the HPF1 family.

9685:ENO3
gene id: 9685:ENO3
uniprot id: M3VX63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9685:PLPP1
gene id: 9685:PLPP1
uniprot id: A0A2I2UTX4
uniprot id: M3X9V6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

9685:CPA3
gene id: 9685:CPA3
uniprot id: M3WTD9
names: Similarity
messages: Belongs to the peptidase M14 family.

9685:SLC19A3
gene id: 9685:SLC19A3
uniprot id: K7REM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

9685:ENTPD1
gene id: 9685:ENTPD1
uniprot id: M3WJX1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9685:TPRG1
gene id: 9685:TPRG1
uniprot id: A0A2I2V4X0
names: Similarity
messages: Belongs to the TPRG1 family.

9685:CCNH
gene id: 9685:CCNH
uniprot id: M3W2X6
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9685:PPA2
gene id: 9685:PPA2
uniprot id: M3XD71
names: Similarity
messages: Belongs to the PPase family.

9685:LOC101084636
gene id: 9685:LOC101084636
uniprot id: A0A337STW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9685:SLC7A1
gene id: 9685:SLC7A1
uniprot id: A0A337SSZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9685:PPP2CB
gene id: 9685:PPP2CB
uniprot id: M3X2E6
names: Similarity
messages: Belongs to the PPP phosphatase family.

9685:SPTLC2
gene id: 9685:SPTLC2
uniprot id: M3VX05
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9685:PPP4C
gene id: 9685:PPP4C
uniprot id: M3WK76
names: Similarity
messages: Belongs to the PPP phosphatase family.

9685:MPI
gene id: 9685:MPI
uniprot id: A0A337SGZ2
uniprot id: A0A5F5XIZ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9685:TENT5B
gene id: 9685:TENT5B
uniprot id: M3WD15
names: Similarity
messages: Belongs to the TENT family.

9685:PLAG1
gene id: 9685:PLAG1
uniprot id: M3WLQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9685:HACL1
gene id: 9685:HACL1
uniprot id: A0A337SXX1
names: Similarity
messages: Belongs to the TPP enzyme family.

9685:PIM1
gene id: 9685:PIM1
uniprot id: Q95LJ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated (By similarity). Phosphorylated. Interaction with PPP2CA promotes dephosphorylation (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Binds to RP9. Interacts with CDKN1B and FOXO3. Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM1, ubiquitination and proteasomal degradation. Interacts with HSP90, this interaction stabilizes PIM1 protein levels. Interacts (ubiquitinated form) with HSP70 and promotes its proteosomal degradation. Interacts with CDKN1A. Interacts with CDC25A and CDC25C. Interacts with MAP3K5. Interacts with MYC.
messages: Cytoplasm
messages: Nucleus
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 protein binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells. Promotes brown adipocyte differentiation.
messages: Ubiquitinated, leading to proteasomal degradation.

9685:EPC2
gene id: 9685:EPC2
uniprot id: A0A337SGT8
uniprot id: M3X061
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9685:SIGMAR1
gene id: 9685:SIGMAR1
uniprot id: M3WWZ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

9685:TACC1
gene id: 9685:TACC1
uniprot id: A0A2I2U0F6
uniprot id: M3WQH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9685:ACO1
gene id: 9685:ACO1
uniprot id: M3VWD8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

9685:CAPN5
gene id: 9685:CAPN5
uniprot id: A0A337SKD2
names: Similarity
messages: Belongs to the peptidase C2 family.

9685:RIC3
gene id: 9685:RIC3
uniprot id: A0A337SEY3
names: Similarity
messages: Belongs to the ric-3 family.

9685:LOC101101385
gene id: 9685:LOC101101385
uniprot id: M3X7Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:POLB
gene id: 9685:POLB
uniprot id: M3XC91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

9685:MTG1
gene id: 9685:MTG1
uniprot id: A0A337S1W7
uniprot id: M3WXQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Mitochondrion inner membrane
messages: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

9685:PSKH1
gene id: 9685:PSKH1
uniprot id: M3WZQ5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:SRP14
gene id: 9685:SRP14
uniprot id: A0A2I2UKX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

9685:RORB
gene id: 9685:RORB
uniprot id: A0A2I2UKU6
uniprot id: M3WF32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9685:LOC101084019
gene id: 9685:LOC101084019
uniprot id: A0A337SHJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MOCS1
gene id: 9685:MOCS1
uniprot id: A0A2I2U4C9
uniprot id: M3W5V6
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9685:RPL27A
gene id: 9685:RPL27A
uniprot id: M3W9J7
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9685:FYN
gene id: 9685:FYN
uniprot id: A0A5K1VSM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9685:PDK3
gene id: 9685:PDK3
uniprot id: A0A337RZ08
uniprot id: M3VXY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9685:SIDT1
gene id: 9685:SIDT1
uniprot id: A0A2I2V064
uniprot id: M3W303
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9685:LOC101091307
gene id: 9685:LOC101091307
uniprot id: M3WVZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9685:LOC101100389
gene id: 9685:LOC101100389
uniprot id: M3WNW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:OLFML2A
gene id: 9685:OLFML2A
uniprot id: M3W012
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:MRPS11
gene id: 9685:MRPS11
uniprot id: M3WLP4
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9685:ST3GAL4
gene id: 9685:ST3GAL4
uniprot id: A0A337S360
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9685:LOC101090367
gene id: 9685:LOC101090367
uniprot id: M3W2L7
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9685:VAMP7
gene id: 9685:VAMP7
uniprot id: M3X847
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9685:ANXA5
gene id: 9685:ANXA5
uniprot id: M3W269
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9685:POGLUT2
gene id: 9685:POGLUT2
uniprot id: M3W1S1
names: Similarity
messages: Belongs to the KDELC family.

9685:ITGAM
gene id: 9685:ITGAM
uniprot id: A0A5F5XIT3
uniprot id: A0A5F5XIV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9685:LOC105260977
gene id: 9685:LOC105260977
uniprot id: A0A2I2UCY9
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9685:RAB33A
gene id: 9685:RAB33A
uniprot id: A0A2I2UDD0
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9685:LDB2
gene id: 9685:LDB2
uniprot id: M3WCN7
names: Similarity
messages: Belongs to the LDB family.

9685:LIPK
gene id: 9685:LIPK
uniprot id: M3W797
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9685:PARD3B
gene id: 9685:PARD3B
uniprot id: A0A337SQS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

9685:ATP6V1A
gene id: 9685:ATP6V1A
uniprot id: M3X6U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

9685:LOC101096719
gene id: 9685:LOC101096719
uniprot id: A0A337SPR9
uniprot id: A0A5F5XQ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9685:UTP15
gene id: 9685:UTP15
uniprot id: M3X7S6
names: Subcellular Location Annotation
messages: nucleolus

9685:HSF1
gene id: 9685:HSF1
uniprot id: A0A2I2UKG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9685:LOC101090867
gene id: 9685:LOC101090867
uniprot id: M3XBK8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9685:PEG3
gene id: 9685:PEG3
uniprot id: A0A2I2V165
names: Subcellular Location Annotation
messages: Nucleus

9685:IPMK
gene id: 9685:IPMK
uniprot id: A0A337SC60
uniprot id: M3XDC4
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9685:SLC9C1
gene id: 9685:SLC9C1
uniprot id: M3VZL9
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9685:HSPA5
gene id: 9685:HSPA5
uniprot id: M3WFT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen

9685:LOC101098821
gene id: 9685:LOC101098821
uniprot id: A0A337SR22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TAF6
gene id: 9685:TAF6
uniprot id: M3W0J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9685:NRM
gene id: 9685:NRM
uniprot id: A0A337SB86
uniprot id: M3W866
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9685:LOC101082738
gene id: 9685:LOC101082738
uniprot id: M3W7G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CBLIF
gene id: 9685:CBLIF
uniprot id: M3W7W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9685:ANPEP
gene id: 9685:ANPEP
uniprot id: P79171
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) In case of feline coronavirus (FCoV) infection, serves as a receptor for FCoV spike glycoprotein. It is as well a receptor for other serogroup I coronaviruses, like canine coronavirus (CCoV), porcine transmissible gastroenteritis virus (TGEV), and human coronavirus 229E (HCoV-229E). Also serves as a receptor for infectious bronchitis virus (IBV, Arkansas 99 serotype) in serogroup III.
messages: (Microbial infection) Interacts with FCoV, CCoV, TGEV and HCoV-229E spike glycoprotein.
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
messages: Cell membrane
messages: Homodimer. Interacts with SLC6A19 (By similarity).
messages: May undergo proteolysis and give rise to a soluble form.
messages: N- and O-glycosylated.
messages: Sulfated.

9685:PRDM1
gene id: 9685:PRDM1
uniprot id: M3WDV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9685:LIG4
gene id: 9685:LIG4
uniprot id: M3XAQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9685:LOC101095289
gene id: 9685:LOC101095289
uniprot id: M3WHJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TSPAN5
gene id: 9685:TSPAN5
uniprot id: M3WK43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:INSM2
gene id: 9685:INSM2
uniprot id: M3XFK5
names: Subcellular Location Annotation
messages: Nucleus

9685:PI4KB
gene id: 9685:PI4KB
uniprot id: M3W4A4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9685:GJA5
gene id: 9685:GJA5
uniprot id: M3VUK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:LOC101091225
gene id: 9685:LOC101091225
uniprot id: M3XFH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:H1-5
gene id: 9685:H1-5
uniprot id: M3W584
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9685:GNG14
gene id: 9685:GNG14
uniprot id: M3X5V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9685:LOC101081729
gene id: 9685:LOC101081729
uniprot id: M3WTB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SERPINB12
gene id: 9685:SERPINB12
uniprot id: A0A2I2UMR7
names: Similarity
messages: Belongs to the serpin family.

9685:ATP9A
gene id: 9685:ATP9A
uniprot id: A0A2I2UVW2
uniprot id: A0A337S144
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9685:FPGS
gene id: 9685:FPGS
uniprot id: A0A337ST19
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

9685:CCND2
gene id: 9685:CCND2
uniprot id: M3VU57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9685:STRIP2
gene id: 9685:STRIP2
uniprot id: M3WSE1
names: Similarity
messages: Belongs to the STRIP family.

9685:CYBC1
gene id: 9685:CYBC1
uniprot id: A0A2I2UHW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:ACOX2
gene id: 9685:ACOX2
uniprot id: M3VY35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9685:HSPA9
gene id: 9685:HSPA9
uniprot id: M3VX55
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9685:ASB17
gene id: 9685:ASB17
uniprot id: M3VVX1
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9685:METTL4
gene id: 9685:METTL4
uniprot id: M3WNV8
names: Similarity
messages: Belongs to the MT-A70-like family.

9685:ABCD1
gene id: 9685:ABCD1
uniprot id: M3W1G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9685:SERPINI2
gene id: 9685:SERPINI2
uniprot id: A0A2I2UTJ5
names: Similarity
messages: Belongs to the serpin family.

9685:LOC101089343
gene id: 9685:LOC101089343
uniprot id: M3WW42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9685:HSPD1
gene id: 9685:HSPD1
uniprot id: M3WXZ4
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9685:IRAK1BP1
gene id: 9685:IRAK1BP1
uniprot id: M3WXP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9685:DBR1
gene id: 9685:DBR1
uniprot id: M3WYY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

9685:ATP23
gene id: 9685:ATP23
uniprot id: M3XA84
names: Similarity
messages: Belongs to the peptidase M76 family.

9685:CYP3A131
gene id: 9685:CYP3A131
uniprot id: F8WKX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9685:ISL1
gene id: 9685:ISL1
uniprot id: M3WF59
names: Subcellular Location Annotation
messages: Nucleus

9685:PGGT1B
gene id: 9685:PGGT1B
uniprot id: A0A337SDQ6
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9685:ODF2
gene id: 9685:ODF2
uniprot id: A0A337S5F5
uniprot id: M3W4T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9685:SLC52A2
gene id: 9685:SLC52A2
uniprot id: M3W888
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9685:NLN
gene id: 9685:NLN
uniprot id: A0A2I2UQH0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9685:CA9
gene id: 9685:CA9
uniprot id: A0A337S4C7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9685:NUP50
gene id: 9685:NUP50
uniprot id: M3WZW1
names: Subcellular Location Annotation
messages: nuclear pore complex

9685:ACTR10
gene id: 9685:ACTR10
uniprot id: M3WSZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9685:ADORA3
gene id: 9685:ADORA3
uniprot id: M3X1I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9685:CILP2
gene id: 9685:CILP2
uniprot id: M3WKI3
names: Subcellular Location Annotation
messages: extracellular matrix

9685:CCR3
gene id: 9685:CCR3
uniprot id: B6DXF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:TARS1
gene id: 9685:TARS1
uniprot id: A0A337SRL7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9685:MTFR1L
gene id: 9685:MTFR1L
uniprot id: A0A337SAW9
uniprot id: M3WHL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9685:CDK5RAP1
gene id: 9685:CDK5RAP1
uniprot id: M3WM53
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

9685:LOC101088278
gene id: 9685:LOC101088278
uniprot id: M3XGB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ESS2
gene id: 9685:ESS2
uniprot id: M3WQ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9685:DLD
gene id: 9685:DLD
uniprot id: M3W291
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9685:THOC6
gene id: 9685:THOC6
uniprot id: A0A337SCP3
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9685:TAMM41
gene id: 9685:TAMM41
uniprot id: M3X3C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9685:CNOT7
gene id: 9685:CNOT7
uniprot id: A0A337SI41
uniprot id: M3VV22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9685:MOGAT2
gene id: 9685:MOGAT2
uniprot id: M3W2J6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:TMEM150B
gene id: 9685:TMEM150B
uniprot id: M3W4F7
names: Subcellular Location Annotation
messages: Membrane

9685:PELO
gene id: 9685:PELO
uniprot id: A0A2I2UYB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: Interacts with PINK1, ABCE1 and CNOT4.
messages: May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
messages: Nucleus

9685:ADM
gene id: 9685:ADM
uniprot id: A0A337S6E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

9685:TSPAN6
gene id: 9685:TSPAN6
uniprot id: M3W038
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:ACBD5
gene id: 9685:ACBD5
uniprot id: M3WGY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9685:FCF1
gene id: 9685:FCF1
uniprot id: M3XA89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9685:TAFA1
gene id: 9685:TAFA1
uniprot id: A0A337S5A6
names: Similarity
messages: Belongs to the TAFA family.

9685:FAM53C
gene id: 9685:FAM53C
uniprot id: M3VX53
names: Similarity
messages: Belongs to the FAM53 family.

9685:GFOD1
gene id: 9685:GFOD1
uniprot id: A0A5F5XVF0
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9685:TBL1XR1
gene id: 9685:TBL1XR1
uniprot id: A0A337SNU8
names: Similarity
messages: Belongs to the WD repeat EBI family.

9685:ULK3
gene id: 9685:ULK3
uniprot id: M3W121
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:AQP7
gene id: 9685:AQP7
uniprot id: A0A337S127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9685:BRINP3
gene id: 9685:BRINP3
uniprot id: M3XDI2
names: Similarity
messages: Belongs to the BRINP family.

9685:PLPPR4
gene id: 9685:PLPPR4
uniprot id: A0A337SCK5
uniprot id: B3GAJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9685:LOC101094933
gene id: 9685:LOC101094933
uniprot id: M3XET7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PRR15L
gene id: 9685:PRR15L
uniprot id: A0A5F5Y299
names: Similarity
messages: Belongs to the PRR15 family.

9685:DYRK3
gene id: 9685:DYRK3
uniprot id: M3XF30
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9685:BUD31
gene id: 9685:BUD31
uniprot id: M3X8H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9685:PRRT1
gene id: 9685:PRRT1
uniprot id: A0A2I2U136
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9685:PDE6G
gene id: 9685:PDE6G
uniprot id: P61248
names: Function
names: Similarity
names: Subunit
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (By similarity).

9685:LOC101080269
gene id: 9685:LOC101080269
uniprot id: A0A337SE90
uniprot id: A0A337SIX3
uniprot id: M3WDI0
names: Similarity
messages: Belongs to the Luc7 family.

9685:ARPC5L
gene id: 9685:ARPC5L
uniprot id: M3X385
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: May be a component of the Arp2/3 complex in which it may replace ARPC5.
messages: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9685:LOC101099185
gene id: 9685:LOC101099185
uniprot id: A0A337S974
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PELI1
gene id: 9685:PELI1
uniprot id: M3XET5
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9685:ST6GAL2
gene id: 9685:ST6GAL2
uniprot id: A0A2I2V3C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

9685:EMC4
gene id: 9685:EMC4
uniprot id: M3VX67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:NDUFAF4
gene id: 9685:NDUFAF4
uniprot id: M3WY80
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9685:RHBDL2
gene id: 9685:RHBDL2
uniprot id: M3VZX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9685:GPR156
gene id: 9685:GPR156
uniprot id: M3WCZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9685:TSHR
gene id: 9685:TSHR
uniprot id: A0A2I2U839
uniprot id: A0A2I2ULI7
uniprot id: A0A2I2UW04
uniprot id: A0A2I2V0E6
uniprot id: A0A337SC75
uniprot id: Q9BGN4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Glycosylated.
messages: Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production. Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
messages: Sulfated. Sulfation on Tyr-384 plays a role in thyrotropin receptor binding and activation.

9685:SRD5A2
gene id: 9685:SRD5A2
uniprot id: M3WDH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9685:MAN2B1
gene id: 9685:MAN2B1
uniprot id: O46432
names: Cofactor
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.
messages: Defects in MAN2B1 are the cause of lysosomal alpha-mannosidosis (AM). AM is a lysosomal storage disease characterized by accumulation of unbranched oligosaccharide chains.
messages: Lysosome
messages: Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.
messages: Processed into 3 peptides of 72 kDa, 41 kDa and 12 kDa.

9685:BNIP1
gene id: 9685:BNIP1
uniprot id: A0A337SNU4
names: Subcellular Location Annotation
messages: Membrane

9685:TMEM120B
gene id: 9685:TMEM120B
uniprot id: M3WID3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9685:GGT6
gene id: 9685:GGT6
uniprot id: A0A337SW58
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9685:MGAT5B
gene id: 9685:MGAT5B
uniprot id: M3W1T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:RPRM
gene id: 9685:RPRM
uniprot id: A0A2I2U659
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Cytoplasm
messages: Membrane

9685:SNX4
gene id: 9685:SNX4
uniprot id: M3X902
names: Similarity
messages: Belongs to the sorting nexin family.

9685:MRRF
gene id: 9685:MRRF
uniprot id: A0A337SQR8
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9685:MRPL13
gene id: 9685:MRPL13
uniprot id: A0A5F5XG25
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9685:TUBB1
gene id: 9685:TUBB1
uniprot id: B5LX42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9685:GAL3ST1
gene id: 9685:GAL3ST1
uniprot id: A0A2I2V3T8
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9685:HOXC4
gene id: 9685:HOXC4
uniprot id: A0A2I2ULB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9685:ZNF326
gene id: 9685:ZNF326
uniprot id: M3X8Q9
names: Similarity
messages: Belongs to the AKAP95 family.

9685:TLCD4
gene id: 9685:TLCD4
uniprot id: M3WTX6
names: Subcellular Location Annotation
messages: Membrane

9685:LONP2
gene id: 9685:LONP2
uniprot id: A0A5F5XL09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
messages: Belongs to the peptidase S16 family.
messages: Interacts with PEX5. Interacts with TYSND1.
messages: Peroxisome matrix

9685:TMED10
gene id: 9685:TMED10
uniprot id: M3VWQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:PSMA5
gene id: 9685:PSMA5
uniprot id: A0A2I2UNM4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9685:DSP
gene id: 9685:DSP
uniprot id: M3WCK3
names: Subcellular Location Annotation
messages: cytoskeleton

9685:CCDC90B
gene id: 9685:CCDC90B
uniprot id: M3X851
names: Similarity
messages: Belongs to the CCDC90 family.

9685:LOC102900869
gene id: 9685:LOC102900869
uniprot id: A0A2I2U4A5
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9685:CD14
gene id: 9685:CD14
uniprot id: M3VWC6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft
messages: Secreted

9685:DHX58
gene id: 9685:DHX58
uniprot id: M3VXZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9685:CEP44
gene id: 9685:CEP44
uniprot id: A0A2I2V3F3
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9685:EDN2
gene id: 9685:EDN2
uniprot id: Q5NRQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides.
messages: Secreted

9685:CA4
gene id: 9685:CA4
uniprot id: M3WAR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Interacts with SLC4A4.
messages: Membrane
messages: Reversible hydration of carbon dioxide.

9685:P2RY13
gene id: 9685:P2RY13
uniprot id: A0A337SNR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:TRPC5
gene id: 9685:TRPC5
uniprot id: M3WDM1
names: Subcellular Location Annotation
messages: Membrane

9685:MIPEP
gene id: 9685:MIPEP
uniprot id: M3WC78
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9685:CAP1
gene id: 9685:CAP1
uniprot id: M3WH00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers.
messages: Membrane

9685:TAP2
gene id: 9685:TAP2
uniprot id: A0A2I2URY5
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9685:ALG11
gene id: 9685:ALG11
uniprot id: M3X9F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9685:TMEM98
gene id: 9685:TMEM98
uniprot id: A0A337S9J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9685:ENSA
gene id: 9685:ENSA
uniprot id: M3X3H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9685:MMP10
gene id: 9685:MMP10
uniprot id: M3WNA6
names: Similarity
messages: Belongs to the peptidase M10A family.

9685:CPSF3
gene id: 9685:CPSF3
uniprot id: M3W8I0
names: Subcellular Location Annotation
messages: Nucleus

9685:FARS2
gene id: 9685:FARS2
uniprot id: A0A5F5XFQ5
uniprot id: A0A5F5XK13
uniprot id: A0A5F5XSG3
uniprot id: M3XBZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

9685:CRYBA1
gene id: 9685:CRYBA1
uniprot id: M3WH19
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9685:ITGA1
gene id: 9685:ITGA1
uniprot id: A0A2I2UF78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9685:SAR1A
gene id: 9685:SAR1A
uniprot id: M3X5G3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9685:ASRGL1
gene id: 9685:ASRGL1
uniprot id: M3WAC3
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9685:RAB3A
gene id: 9685:RAB3A
uniprot id: A0A2I2V025
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9685:HS3ST6
gene id: 9685:HS3ST6
uniprot id: A0A2I2V3N3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9685:CNDP1
gene id: 9685:CNDP1
uniprot id: M3W9A4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9685:UNC45B
gene id: 9685:UNC45B
uniprot id: M3VUD5
names: Subcellular Location Annotation
messages: A band
messages: Z line
messages: perinuclear region

9685:AP1M1
gene id: 9685:AP1M1
uniprot id: M3WAM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9685:TUBB6
gene id: 9685:TUBB6
uniprot id: A0A2I2UAT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9685:DUSP6
gene id: 9685:DUSP6
uniprot id: M3XBD2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9685:TMEM59
gene id: 9685:TMEM59
uniprot id: M3X067
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:CAV2
gene id: 9685:CAV2
uniprot id: A0M8S6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
messages: Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By. similarity).
messages: caveola

9685:LOC101086846
gene id: 9685:LOC101086846
uniprot id: A0A2I2U6N1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9685:IGF2BP2
gene id: 9685:IGF2BP2
uniprot id: A0A337S262
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9685:LRRFIP1
gene id: 9685:LRRFIP1
uniprot id: A0A5F5Y103
names: Similarity
messages: Belongs to the LRRFIP family.

9685:RNF7
gene id: 9685:RNF7
uniprot id: A0A2I2U1X7
names: Similarity
messages: Belongs to the RING-box family.

9685:CMAH
gene id: 9685:CMAH
uniprot id: A0A143T1T8
uniprot id: A0A337SEU8
uniprot id: A0A5F5XEJ2
uniprot id: A0A5F5XQ06
uniprot id: A6Y8N2
names: Function
names: Similarity
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

9685:IRAK4
gene id: 9685:IRAK4
uniprot id: A0A337S8S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9685:PHB2
gene id: 9685:PHB2
uniprot id: M3X4F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9685:SRSF1
gene id: 9685:SRSF1
uniprot id: M3VY56
names: Similarity
messages: Belongs to the splicing factor SR family.

9685:LOC101091513
gene id: 9685:LOC101091513
uniprot id: M3WVZ1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RPIA
gene id: 9685:RPIA
uniprot id: A0A2I2U7J2
uniprot id: M3W8G6
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9685:LOC101080380
gene id: 9685:LOC101080380
uniprot id: M3WZ13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TRIAP1
gene id: 9685:TRIAP1
uniprot id: A0A2I2US39
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9685:ALB
gene id: 9685:ALB
uniprot id: P49064
names: Allergen
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
messages: Can cause allergic reactions in humans.
messages: Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Plasma.
messages: Secreted

9685:SLC26A5
gene id: 9685:SLC26A5
uniprot id: B5TGH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ.

9685:RPS10
gene id: 9685:RPS10
uniprot id: M3WMF9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9685:RHO
gene id: 9685:RHO
uniprot id: Q95KU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.
messages: Homodimer (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts with GRK1 (By similarity). Interacts (phosphorylated form) with SAG. Interacts with GNAT1. Interacts with GNAT3. SAG and G-proteins compete for a common binding site (By similarity). Interacts with PRCD; the interaction promotes PRCD stability.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
messages: photoreceptor outer segment

9685:PAQR3
gene id: 9685:PAQR3
uniprot id: M3X871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9685:BRAF
gene id: 9685:BRAF
uniprot id: A0A2I2ULH6
uniprot id: M3WHQ7
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9685:INS
gene id: 9685:INS
uniprot id: P06306
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

9685:NKAIN2
gene id: 9685:NKAIN2
uniprot id: A0A2I2U4U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9685:LOC101092875
gene id: 9685:LOC101092875
uniprot id: A0A2I2U5A3
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9685:THBS2
gene id: 9685:THBS2
uniprot id: A0A2I2UG29
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LOC101083202
gene id: 9685:LOC101083202
uniprot id: A0A2I2U0B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:DPPA5
gene id: 9685:DPPA5
uniprot id: M3W6H1
names: Similarity
messages: Belongs to the KHDC1 family.

9685:SEC22C
gene id: 9685:SEC22C
uniprot id: M3X626
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9685:MSRA
gene id: 9685:MSRA
uniprot id: A0A2I2V3Y2
uniprot id: A0A5F5Y0Z9
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

9685:TECPR1
gene id: 9685:TECPR1
uniprot id: M3VUI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TECPR1 family.
messages: Lysosome membrane
messages: autophagosome membrane

9685:LOC677877
gene id: 9685:LOC677877
uniprot id: P30438
names: Allergen
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the secretoglobin family.
messages: Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.
messages: Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.
messages: Saliva and sebaceous glands.
messages: Secreted

9685:LOC101080913
gene id: 9685:LOC101080913
uniprot id: M3WEA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RTRAF
gene id: 9685:RTRAF
uniprot id: M3VYX1
names: Similarity
messages: Belongs to the RTRAF family.

9685:EIF3E
gene id: 9685:EIF3E
uniprot id: M3W0R4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.

9685:LOC101097506
gene id: 9685:LOC101097506
uniprot id: M3WZG7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9685:STARD3NL
gene id: 9685:STARD3NL
uniprot id: M3W9F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9685:ELF4
gene id: 9685:ELF4
uniprot id: M3X1U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:LOC101097564
gene id: 9685:LOC101097564
uniprot id: A0A2I2UHR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9685:SNURF
gene id: 9685:SNURF
uniprot id: M3XBI7
names: Similarity
messages: Belongs to the SNURF family.

9685:SMARCD3
gene id: 9685:SMARCD3
uniprot id: A0A337SWI9
names: Similarity
messages: Belongs to the SMARCD family.

9685:SLC40A1
gene id: 9685:SLC40A1
uniprot id: M3W7S0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

9685:LOC101100535
gene id: 9685:LOC101100535
uniprot id: A0A337SQR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:KEF43 p13
gene id: 9685:KEF43_p13
uniprot id: P48900
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9685:KCNJ11
gene id: 9685:KCNJ11
uniprot id: M3W7H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9685:ELL2
gene id: 9685:ELL2
uniprot id: M3XFW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9685:VAMP4
gene id: 9685:VAMP4
uniprot id: M3WIR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9685:KIF3C
gene id: 9685:KIF3C
uniprot id: M3WMZ5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:TRAF5
gene id: 9685:TRAF5
uniprot id: A0A2I2U801
uniprot id: M3VXY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9685:AK2
gene id: 9685:AK2
uniprot id: A0A337SDR5
uniprot id: A0A337SGU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9685:CA1
gene id: 9685:CA1
uniprot id: M3XGD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9685:ANO2
gene id: 9685:ANO2
uniprot id: M3W6M2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:RPL10L
gene id: 9685:RPL10L
uniprot id: M3WLF1
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9685:SLCO1A2
gene id: 9685:SLCO1A2
uniprot id: M3WPM9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:PHKA1
gene id: 9685:PHKA1
uniprot id: M3W753
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9685:HSD17B2
gene id: 9685:HSD17B2
uniprot id: M3W394
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:HIBCH
gene id: 9685:HIBCH
uniprot id: A0A337SQA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9685:HYOU1
gene id: 9685:HYOU1
uniprot id: M3VW30
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9685:LIN28A
gene id: 9685:LIN28A
uniprot id: D3U660
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9685:MTF2
gene id: 9685:MTF2
uniprot id: M3WLT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9685:KRTAP11-1
gene id: 9685:KRTAP11-1
uniprot id: A0A337S0Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9685:TBRG1
gene id: 9685:TBRG1
uniprot id: A0A2I2UEK1
names: Subcellular Location Annotation
messages: Nucleus

9685:PHC1
gene id: 9685:PHC1
uniprot id: M3WMA6
names: Subcellular Location Annotation
messages: Nucleus

9685:LIPF
gene id: 9685:LIPF
uniprot id: M3W796
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9685:IPO9
gene id: 9685:IPO9
uniprot id: M3VUS3
names: Subcellular Location Annotation
messages: Cytoplasm

9685:TSR1
gene id: 9685:TSR1
uniprot id: M3W5N8
names: Subcellular Location Annotation
messages: nucleolus

9685:SNX20
gene id: 9685:SNX20
uniprot id: A0A2I2UZN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9685:ATG5
gene id: 9685:ATG5
uniprot id: A0A337SIJ7
uniprot id: M3WW94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9685:CCNL1
gene id: 9685:CCNL1
uniprot id: M3W3J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

9685:CCNJL
gene id: 9685:CCNJL
uniprot id: M3XA43
names: Similarity
messages: Belongs to the cyclin family.

9685:HDAC7
gene id: 9685:HDAC7
uniprot id: A0A2I2UC12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9685:LOC101089458
gene id: 9685:LOC101089458
uniprot id: A0A5F5XW59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TSPAN4
gene id: 9685:TSPAN4
uniprot id: A0A337SDZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9685:LEF1
gene id: 9685:LEF1
uniprot id: A0A2I2U3V9
uniprot id: A0A337SI72
uniprot id: A0A337SR54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9685:PLSCR5
gene id: 9685:PLSCR5
uniprot id: M3XDI5
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9685:BCHE
gene id: 9685:BCHE
uniprot id: O62760
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity).
messages: Homotetramer; disulfide-linked. Dimer of dimers (By similarity).
messages: Secreted

9685:PDGFB
gene id: 9685:PDGFB
uniprot id: W5LV43
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9685:ACP1
gene id: 9685:ACP1
uniprot id: A0A337S8L4
uniprot id: A0A337STI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9685:LOC105260536
gene id: 9685:LOC105260536
uniprot id: M3X726
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:PFDN2
gene id: 9685:PFDN2
uniprot id: M3WGQ1
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9685:STAM
gene id: 9685:STAM
uniprot id: M3XDT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9685:CXCR4
gene id: 9685:CXCR4
uniprot id: P56498
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Late endosome
messages: Lysosome
messages: Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
messages: O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.
messages: Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-325 and Ser-326 leads to recruitment of ITCH, ubiquitination and protein degradation.
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).
messages: Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.
messages: Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S.

9685:LOC101095915
gene id: 9685:LOC101095915
uniprot id: M3WRZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:VCL
gene id: 9685:VCL
uniprot id: M3XCV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9685:ZDHHC22
gene id: 9685:ZDHHC22
uniprot id: A0A2I2U8E7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:GRM7
gene id: 9685:GRM7
uniprot id: A0A337SEA2
uniprot id: A0A337SVS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9685:SLC35A1
gene id: 9685:SLC35A1
uniprot id: M3X514
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9685:GOLT1B
gene id: 9685:GOLT1B
uniprot id: A0A2I2U4L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9685:RPL18
gene id: 9685:RPL18
uniprot id: M3W9Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Rough endoplasmic reticulum

9685:ATP6V1G1
gene id: 9685:ATP6V1G1
uniprot id: A0A2I2V0F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9685:MTTP
gene id: 9685:MTTP
uniprot id: A0A337SN26
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CFI
gene id: 9685:CFI
uniprot id: A0A2I2U350
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:ME2
gene id: 9685:ME2
uniprot id: M3W4G8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9685:LOC101084275
gene id: 9685:LOC101084275
uniprot id: M3X7D1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:IZUMO2
gene id: 9685:IZUMO2
uniprot id: M3W8Q8
names: Similarity
messages: Belongs to the Izumo family.

9685:LOC101080845
gene id: 9685:LOC101080845
uniprot id: M3X0X3
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:UROC1
gene id: 9685:UROC1
uniprot id: M3WN75
names: Similarity
messages: Belongs to the urocanase family.

9685:MED21
gene id: 9685:MED21
uniprot id: A0A2I2UX14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9685:SF3B4
gene id: 9685:SF3B4
uniprot id: M3WCP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9685:CDC45
gene id: 9685:CDC45
uniprot id: A0A2I2UWQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9685:PPIA
gene id: 9685:PPIA
uniprot id: G3XEW5
uniprot id: Q8HXS3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).
messages: Cytoplasm
messages: Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: Secreted

9685:GALE
gene id: 9685:GALE
uniprot id: M3WFT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9685:LOC101087010
gene id: 9685:LOC101087010
uniprot id: M3WFP7
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9685:LOC101091269
gene id: 9685:LOC101091269
uniprot id: M3XA10
names: Similarity
messages: Belongs to the GPRASP family.

9685:AIF1
gene id: 9685:AIF1
uniprot id: A0A2I2USF2
names: Subcellular Location Annotation
messages: ruffle membrane

9685:CYP2D6
gene id: 9685:CYP2D6
uniprot id: E0D568
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9685:STK11
gene id: 9685:STK11
uniprot id: M3WJD3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

9685:CSRNP2
gene id: 9685:CSRNP2
uniprot id: M3W246
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9685:SF3A1
gene id: 9685:SF3A1
uniprot id: M3WG15
names: Subcellular Location Annotation
messages: Nucleus

9685:TFB1M
gene id: 9685:TFB1M
uniprot id: A0A2I2U3W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9685:ZP2
gene id: 9685:ZP2
uniprot id: P47984
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZP domain family. ZPA subfamily.
messages: Can form homopolymers that assemble into long fibers (in vitro). Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. Interacts with ZP3.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
messages: N-glycosylated.
messages: O-glycosylated; contains sulfate-substituted glycans.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9685:IL1RAPL2
gene id: 9685:IL1RAPL2
uniprot id: A0A337SMA0
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9685:NT5C3A
gene id: 9685:NT5C3A
uniprot id: A0A2I2UZM8
uniprot id: M3W6Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9685:ZSCAN25
gene id: 9685:ZSCAN25
uniprot id: A0A2I2UAG2
names: Subcellular Location Annotation
messages: Nucleus

9685:CBFB
gene id: 9685:CBFB
uniprot id: A0A077DAU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

9685:WDR12
gene id: 9685:WDR12
uniprot id: M3WT89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9685:PSME1
gene id: 9685:PSME1
uniprot id: M3W4B6
names: Similarity
messages: Belongs to the PA28 family.

9685:LOC100169654
gene id: 9685:LOC100169654
uniprot id: O19432
names: Similarity
messages: Belongs to the MHC class II family.

9685:TRMT112
gene id: 9685:TRMT112
uniprot id: M3WWU1
names: Similarity
messages: Belongs to the TRM112 family.

9685:TRNT1
gene id: 9685:TRNT1
uniprot id: M3X159
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9685:CAPZA1
gene id: 9685:CAPZA1
uniprot id: M3WIM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9685:CCNA1
gene id: 9685:CCNA1
uniprot id: M3W2K1
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9685:MRPS31
gene id: 9685:MRPS31
uniprot id: A0A2I2ULH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9685:DCAF10
gene id: 9685:DCAF10
uniprot id: A0A5F5Y2H3
uniprot id: M3WPP0
names: Function
names: Similarity
messages: Belongs to the WD repeat DCAF10 family.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9685:STK32A
gene id: 9685:STK32A
uniprot id: M3W983
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:SV2C
gene id: 9685:SV2C
uniprot id: M3W047
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9685:LOC101084939
gene id: 9685:LOC101084939
uniprot id: M3WAR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101093269
gene id: 9685:LOC101093269
uniprot id: M3XAW8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:CNP
gene id: 9685:CNP
uniprot id: M3WWG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

9685:NCAPH
gene id: 9685:NCAPH
uniprot id: A0A2I2UVW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

9685:MYO1A
gene id: 9685:MYO1A
uniprot id: M3WKY0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9685:LOC101086605
gene id: 9685:LOC101086605
uniprot id: A0A2I2UUI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9685:SARS1
gene id: 9685:SARS1
uniprot id: A0A2I2UDH0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9685:RNMT
gene id: 9685:RNMT
uniprot id: M3WPI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9685:OCLN
gene id: 9685:OCLN
uniprot id: M3W874
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

9685:SLC16A7
gene id: 9685:SLC16A7
uniprot id: A0A2I2V0S5
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

9685:DAZL
gene id: 9685:DAZL
uniprot id: A0A337SR91
names: Subcellular Location Annotation
messages: Cytoplasm

9685:CENPJ
gene id: 9685:CENPJ
uniprot id: A0A5F5Y7Z8
uniprot id: M3W339
names: Similarity
messages: Belongs to the TCP10 family.

9685:PSD4
gene id: 9685:PSD4
uniprot id: M3WBP9
names: Subcellular Location Annotation
messages: ruffle membrane

9685:KRT74
gene id: 9685:KRT74
uniprot id: A0A5K1UI54
names: Similarity
messages: Belongs to the intermediate filament family.

9685:CLCC1
gene id: 9685:CLCC1
uniprot id: M3WE17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

9685:OSBP2
gene id: 9685:OSBP2
uniprot id: M3W1K3
names: Similarity
messages: Belongs to the OSBP family.

9685:CIBAR2
gene id: 9685:CIBAR2
uniprot id: M3X5X5
names: Subcellular Location Annotation
messages: centriole
messages: cilium basal body

9685:SH2B1
gene id: 9685:SH2B1
uniprot id: A0A337RXI4
uniprot id: M3VZQ4
names: Similarity
messages: Belongs to the SH2B adapter family.

9685:TMEM182
gene id: 9685:TMEM182
uniprot id: M3X0N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9685:ESD
gene id: 9685:ESD
uniprot id: M3XAF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9685:CR2
gene id: 9685:CR2
uniprot id: A0A337SJR3
uniprot id: A0A337SM81
uniprot id: A0A5F5XQ34
uniprot id: M3WDJ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:IL1F10
gene id: 9685:IL1F10
uniprot id: A0A2I2U952
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9685:KHDRBS1
gene id: 9685:KHDRBS1
uniprot id: M3W616
names: Similarity
messages: Belongs to the KHDRBS family.

9685:LOC101088417
gene id: 9685:LOC101088417
uniprot id: A0A337S7L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9685:SNTG1
gene id: 9685:SNTG1
uniprot id: A0A2I2V1B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9685:LOC101093163
gene id: 9685:LOC101093163
uniprot id: A0A337RXZ9
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

9685:B3GALT4
gene id: 9685:B3GALT4
uniprot id: M3W1E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:TIMP4
gene id: 9685:TIMP4
uniprot id: M3XCK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

9685:ADCY8
gene id: 9685:ADCY8
uniprot id: A0A2I2UI83
uniprot id: A0A337S2A8
uniprot id: M3W5W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9685:SH2D1A
gene id: 9685:SH2D1A
uniprot id: M3W9F7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9685:P2RY4
gene id: 9685:P2RY4
uniprot id: M3W927
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:PYGB
gene id: 9685:PYGB
uniprot id: M3W9K0
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9685:USP4
gene id: 9685:USP4
uniprot id: A0A2I2UQD5
uniprot id: M3WC91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9685:MUL1
gene id: 9685:MUL1
uniprot id: M3WWN4
names: Subcellular Location Annotation
messages: Membrane

9685:KIF5A
gene id: 9685:KIF5A
uniprot id: A0A2I2ULS6
uniprot id: A0A337SAI2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:TREM1
gene id: 9685:TREM1
uniprot id: M3VZ43
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:APAF1
gene id: 9685:APAF1
uniprot id: A0A337S9X3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

9685:MMP15
gene id: 9685:MMP15
uniprot id: M3VYZ5
names: Similarity
messages: Belongs to the peptidase M10A family.

9685:RBP2
gene id: 9685:RBP2
uniprot id: A0A2I2ULK3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9685:BCL2
gene id: 9685:BCL2
uniprot id: Q8I008
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

9685:IDS
gene id: 9685:IDS
uniprot id: M3WZT0
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9685:SKAP1
gene id: 9685:SKAP1
uniprot id: M3W2U6
names: Similarity
messages: Belongs to the SKAP family.

9685:PPIL4
gene id: 9685:PPIL4
uniprot id: M3WEU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9685:DRD2
gene id: 9685:DRD2
uniprot id: M3W9B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9685:CIAO1
gene id: 9685:CIAO1
uniprot id: A0A2I2U1R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9685:PGAP3
gene id: 9685:PGAP3
uniprot id: M3WCC1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:MCOLN2
gene id: 9685:MCOLN2
uniprot id: A0A2I2U5R1
uniprot id: M3WEM8
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9685:KCNH3
gene id: 9685:KCNH3
uniprot id: M3WLB8
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9685:WASHC3
gene id: 9685:WASHC3
uniprot id: A0A5F5XE04
names: Similarity
messages: Belongs to the CCDC53 family.

9685:LOC101082183
gene id: 9685:LOC101082183
uniprot id: M3WTT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:VWF
gene id: 9685:VWF
uniprot id: A0A061DD19
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
messages: Multimeric. Interacts with F8.
messages: Secreted
messages: extracellular matrix

9685:IQCD
gene id: 9685:IQCD
uniprot id: M3X8D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9685:TEAD1
gene id: 9685:TEAD1
uniprot id: A0A337RZ88
uniprot id: A0A337S195
uniprot id: A0A337S413
uniprot id: A0A337SMP7
names: Subcellular Location Annotation
messages: Nucleus

9685:LPGAT1
gene id: 9685:LPGAT1
uniprot id: A0A2I2UZZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9685:FGD1
gene id: 9685:FGD1
uniprot id: M3VY47
names: Subcellular Location Annotation
messages: cytoskeleton

9685:MAT1A
gene id: 9685:MAT1A
uniprot id: M3WFC1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9685:SLC19A2
gene id: 9685:SLC19A2
uniprot id: Q27PN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9685:SUOX
gene id: 9685:SUOX
uniprot id: M3WZ66
names: Function
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.

9685:SDR42E1
gene id: 9685:SDR42E1
uniprot id: M3WW99
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9685:LOC101098057
gene id: 9685:LOC101098057
uniprot id: M3XBP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PHKA2
gene id: 9685:PHKA2
uniprot id: A0A2I2UPH9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9685:POMT2
gene id: 9685:POMT2
uniprot id: M3WFM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9685:ADGRL2
gene id: 9685:ADGRL2
uniprot id: A0A2I2U0D3
names: Subcellular Location Annotation
messages: Membrane

9685:NR1I3
gene id: 9685:NR1I3
uniprot id: M3VUV8
uniprot id: M3WN87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein A2 family.
messages: Belongs to the nuclear hormone receptor family.
messages: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
messages: Monomer. Interacts with NAXE and NDRG1.
messages: Nucleus
messages: Secreted

9685:TBX20
gene id: 9685:TBX20
uniprot id: A0A337SBT6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:LOC101096260
gene id: 9685:LOC101096260
uniprot id: M3WIG2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:NUP133
gene id: 9685:NUP133
uniprot id: A0A5F5XER8
uniprot id: M3VVR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

9685:TTC30B
gene id: 9685:TTC30B
uniprot id: M3X6J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9685:MRPS18C
gene id: 9685:MRPS18C
uniprot id: A0A2I2V385
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9685:GSDME
gene id: 9685:GSDME
uniprot id: M3WLI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9685:CABS1
gene id: 9685:CABS1
uniprot id: M3X763
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: acrosome
messages: flagellum

9685:NSDHL
gene id: 9685:NSDHL
uniprot id: A0A2I2V0N8
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9685:SATB1
gene id: 9685:SATB1
uniprot id: A0A2I2V398
uniprot id: M3W1Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9685:GNG8
gene id: 9685:GNG8
uniprot id: M3WBR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9685:TMEM150A
gene id: 9685:TMEM150A
uniprot id: M3XCC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Membrane

9685:SNU13
gene id: 9685:SNU13
uniprot id: M3XA70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9685:GJA4
gene id: 9685:GJA4
uniprot id: M3WK01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:CLGN
gene id: 9685:CLGN
uniprot id: A0A2I2UKH3
names: Similarity
messages: Belongs to the calreticulin family.

9685:CACYBP
gene id: 9685:CACYBP
uniprot id: M3W9V3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9685:SMC3
gene id: 9685:SMC3
uniprot id: M3WDH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

9685:IBSP
gene id: 9685:IBSP
uniprot id: A0A2I2UBD2
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9685:FAM20B
gene id: 9685:FAM20B
uniprot id: M3W3U4
names: Similarity
messages: Belongs to the FAM20 family.

9685:CLEC12B
gene id: 9685:CLEC12B
uniprot id: M3WD61
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:ATIC
gene id: 9685:ATIC
uniprot id: M3WB05
names: Similarity
messages: Belongs to the PurH family.

9685:AGXT
gene id: 9685:AGXT
uniprot id: P41689
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the transamination between L-serine and pyruvate and contributes to gluconeogenesis from the L-serine metabolism.
messages: Catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification.
messages: Homodimer.
messages: Mitochondrion matrix
messages: Peroxisome
messages: The intracellular compartmentalization of AGTX in mammalian hepatocytes is species dependent. In human and rabbit, AGTX is peroxisomal. In new world monkeys (marmoset) and rodents (rat and mouse), it is distributed approximately evenly between peroxisomes and mitochondria. In carnivores, like cat, the great majority of the enzyme is mitochondrial with only a small proportion being peroxisomal.

9685:LOC101092497
gene id: 9685:LOC101092497
uniprot id: A0A2I2UDE9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:GLI1
gene id: 9685:GLI1
uniprot id: M3VXV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9685:VRK1
gene id: 9685:VRK1
uniprot id: A0A2I2V0C2
uniprot id: M3W988
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:PLP2
gene id: 9685:PLP2
uniprot id: M3W114
names: Subcellular Location Annotation
messages: Membrane

9685:ALDOC
gene id: 9685:ALDOC
uniprot id: A0A2I2V3I1
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9685:LOC101081313
gene id: 9685:LOC101081313
uniprot id: M3W082
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SDHD
gene id: 9685:SDHD
uniprot id: M3XAM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9685:LOC102899587
gene id: 9685:LOC102899587
uniprot id: A0A654IDG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:SERINC3
gene id: 9685:SERINC3
uniprot id: M3VUK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9685:LOC101085745
gene id: 9685:LOC101085745
uniprot id: M3WPV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:KRT73
gene id: 9685:KRT73
uniprot id: M1RGZ2
names: Similarity
messages: Belongs to the intermediate filament family.

9685:KCNJ5
gene id: 9685:KCNJ5
uniprot id: A0A2I2UE47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9685:MAP3K7
gene id: 9685:MAP3K7
uniprot id: A0A2I2V2F2
uniprot id: M3WSG5
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9685:NPPA
gene id: 9685:NPPA
uniprot id: Q9GLD0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Cleavage by MME initiates degradation of the factor and thereby regulates its activity. Degradation by IDE results in reduced activation of NPR1 (in vitro). During IDE degradation, the resulting products can temporarily stimulate NPR2 to produce cGMP, before the fragments are completely degraded and inactivated by IDE (in vitro).
messages: Degraded by IDE.
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.
messages: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (By similarity). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (By similarity). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity).
messages: May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity).
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Perikaryon
messages: Phosphorylation on Ser-129 decreases vasorelaxant activity.
messages: Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, a heterologous and in vivo expression study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).
messages: Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, an in vivo study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).
messages: Secreted
messages: The precursor molecule is proteolytically cleaved by CORIN at Arg-123 to produce the atrial natriuretic peptide (By similarity). Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide (By similarity). Additional processing gives rise to the auriculin and atriopeptin peptides (By similarity). In the kidneys, alternative processing by an unknown protease results in the peptide urodilatin (By similarity).

9685:ITGA8
gene id: 9685:ITGA8
uniprot id: M3VY58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9685:PTPRD
gene id: 9685:PTPRD
uniprot id: A0A337RYS5
uniprot id: A0A337S6K7
uniprot id: A0A337SAP0
uniprot id: A0A337SP04
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

9685:VARS2
gene id: 9685:VARS2
uniprot id: A0A337SC93
uniprot id: A0A5F5XT10
uniprot id: M3WDF9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9685:SLC25A41
gene id: 9685:SLC25A41
uniprot id: A0A2I2U3D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:LOC101095392
gene id: 9685:LOC101095392
uniprot id: M3WBI8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:PNOC
gene id: 9685:PNOC
uniprot id: M3X9I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9685:PDP1
gene id: 9685:PDP1
uniprot id: A0A5F5XSB6
names: Similarity
messages: Belongs to the PP2C family.

9685:CXCL10
gene id: 9685:CXCL10
uniprot id: A0A2I2UFH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9685:AKR1B1
gene id: 9685:AKR1B1
uniprot id: M3WHU0
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9685:BDNF
gene id: 9685:BDNF
uniprot id: Q9TST3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).
messages: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.
messages: Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).
messages: Monomers and homodimers (By similarity). Binds to NTRK2/TRKB. Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (By similarity). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower affinity for the heterodimer formed by NGFR and SORCS2 (By similarity).
messages: N-glycosylated and glycosulfated, contrary to mature BDNF.
messages: Secreted

9685:DAXX
gene id: 9685:DAXX
uniprot id: M3W1E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

9685:PLCD1
gene id: 9685:PLCD1
uniprot id: A0A337SD30
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9685:NCAPG
gene id: 9685:NCAPG
uniprot id: M3X3A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9685:PSME2
gene id: 9685:PSME2
uniprot id: A0A337STN2
names: Similarity
messages: Belongs to the PA28 family.

9685:LOC101098304
gene id: 9685:LOC101098304
uniprot id: M3W2E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:MTMR2
gene id: 9685:MTMR2
uniprot id: A0A2I2V2L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9685:MTERF1
gene id: 9685:MTERF1
uniprot id: A0A337RW51
names: Similarity
messages: Belongs to the mTERF family.

9685:NMNAT2
gene id: 9685:NMNAT2
uniprot id: A0A337S342
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9685:GPR37
gene id: 9685:GPR37
uniprot id: A0A2I2UTY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:ITPR2
gene id: 9685:ITPR2
uniprot id: M3W202
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9685:RBM47
gene id: 9685:RBM47
uniprot id: A0A2I2UUV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Nucleus

9685:MYH6
gene id: 9685:MYH6
uniprot id: M3WAS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9685:IL2RA
gene id: 9685:IL2RA
uniprot id: P41690
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9685:STK40
gene id: 9685:STK40
uniprot id: M3W3R6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9685:VEPH1
gene id: 9685:VEPH1
uniprot id: A0A2I2V3G9
uniprot id: A0A2I2V484
names: Similarity
messages: Belongs to the MELT/VEPH family.

9685:LOC101083921
gene id: 9685:LOC101083921
uniprot id: M3WSM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:HOXB5
gene id: 9685:HOXB5
uniprot id: A0A2I2V4A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9685:ARVCF
gene id: 9685:ARVCF
uniprot id: A0A2I2UM81
uniprot id: A0A2I2UNP3
names: Similarity
messages: Belongs to the beta-catenin family.

9685:GDNF
gene id: 9685:GDNF
uniprot id: A0A2I2ULX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9685:LRRC8A
gene id: 9685:LRRC8A
uniprot id: M3W4V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9685:GTPBP1
gene id: 9685:GTPBP1
uniprot id: A0A337SNQ7
uniprot id: M3WE54
names: Function
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.

9685:C3AR1
gene id: 9685:C3AR1
uniprot id: M3WTC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9685:HOXA9
gene id: 9685:HOXA9
uniprot id: A0A337SVI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9685:LAMTOR4
gene id: 9685:LAMTOR4
uniprot id: A0A5F5Y7N9
names: Similarity
messages: Belongs to the LAMTOR4 family.

9685:LOC101100692
gene id: 9685:LOC101100692
uniprot id: M3WU09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:DHX8
gene id: 9685:DHX8
uniprot id: M3WCC5
names: Subcellular Location Annotation
messages: Nucleus

9685:THUMPD3
gene id: 9685:THUMPD3
uniprot id: M3W5F4
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9685:PPIL2
gene id: 9685:PPIL2
uniprot id: A0A2I2UX72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9685:LOC101099147
gene id: 9685:LOC101099147
uniprot id: M3WBV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:BTF3L4
gene id: 9685:BTF3L4
uniprot id: A0A2I2UTY2
names: Similarity
messages: Belongs to the NAC-beta family.

9685:FLAI-K
gene id: 9685:FLAI-K
uniprot id: S4Z3H8
names: Similarity
messages: Belongs to the MHC class I family.

9685:HSP90B1
gene id: 9685:HSP90B1
uniprot id: M3WK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9685:MB
gene id: 9685:MB
uniprot id: M3WCL7
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9685:STAR
gene id: 9685:STAR
uniprot id: F5CT15
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9685:PREB
gene id: 9685:PREB
uniprot id: M3W3K4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9685:NAP1L1
gene id: 9685:NAP1L1
uniprot id: A0A337SCC2
uniprot id: A0A337SMA3
uniprot id: M3VUF4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9685:COG6
gene id: 9685:COG6
uniprot id: A0A5F5XTZ2
uniprot id: M3WQM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9685:AOC1
gene id: 9685:AOC1
uniprot id: M3XC22
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9685:SLC30A7
gene id: 9685:SLC30A7
uniprot id: M3WED5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9685:SUPT5H
gene id: 9685:SUPT5H
uniprot id: A0A337S2P9
uniprot id: M3WDU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9685:NECAP1
gene id: 9685:NECAP1
uniprot id: M3VYB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9685:EZH1
gene id: 9685:EZH1
uniprot id: M3WIA3
names: Subcellular Location Annotation
messages: Nucleus

9685:PRUNE1
gene id: 9685:PRUNE1
uniprot id: M3X7L1
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9685:KIF4A
gene id: 9685:KIF4A
uniprot id: M3W9X8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9685:FOXO4
gene id: 9685:FOXO4
uniprot id: M3WZ98
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC102899397
gene id: 9685:LOC102899397
uniprot id: A0A5F5XMJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9685:NLK
gene id: 9685:NLK
uniprot id: M3W7I9
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9685:TSPO2
gene id: 9685:TSPO2
uniprot id: A0A2I2UNV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9685:SEC24C
gene id: 9685:SEC24C
uniprot id: M3WE89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9685:COG2
gene id: 9685:COG2
uniprot id: M3WJ10
names: Similarity
messages: Belongs to the COG2 family.

9685:PPIB
gene id: 9685:PPIB
uniprot id: G3XEW6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9685:PRKAR1B
gene id: 9685:PRKAR1B
uniprot id: M3X8Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9685:ANKRD13B
gene id: 9685:ANKRD13B
uniprot id: M3VZ34
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9685:IL1R1
gene id: 9685:IL1R1
uniprot id: M3WGF1
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9685:PLAC8B
gene id: 9685:PLAC8B
uniprot id: M3WCX9
names: Similarity
messages: Belongs to the cornifelin family.

9685:SLC25A21
gene id: 9685:SLC25A21
uniprot id: A0A337S7D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:CLCN3
gene id: 9685:CLCN3
uniprot id: A0A2I2UD99
uniprot id: A0A2I2UQQ6
uniprot id: M3VVD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9685:PFKFB2
gene id: 9685:PFKFB2
uniprot id: A0A2I2UYD2
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9685:ANXA1
gene id: 9685:ANXA1
uniprot id: Q6BCI9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9685:IP6K1
gene id: 9685:IP6K1
uniprot id: A0A2I2U3X1
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9685:MFNG
gene id: 9685:MFNG
uniprot id: M3W6C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:LOC101093799
gene id: 9685:LOC101093799
uniprot id: M3W5Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101095032
gene id: 9685:LOC101095032
uniprot id: A0A337SWK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9685:LOC101094779
gene id: 9685:LOC101094779
uniprot id: M3X7P2
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9685:LOC101100755
gene id: 9685:LOC101100755
uniprot id: M3XEE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GGA3
gene id: 9685:GGA3
uniprot id: A0A337S3F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9685:NINJ2
gene id: 9685:NINJ2
uniprot id: A0A337SQL8
uniprot id: M3WAH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9685:LOC101080738
gene id: 9685:LOC101080738
uniprot id: A0A5F5XE12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CYBRD1
gene id: 9685:CYBRD1
uniprot id: A0A2I2URT2
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9685:PIWIL4
gene id: 9685:PIWIL4
uniprot id: M3WE65
names: Similarity
messages: Belongs to the argonaute family.

9685:COX7A2L
gene id: 9685:COX7A2L
uniprot id: A0A2I2UF99
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9685:TESMIN
gene id: 9685:TESMIN
uniprot id: M3XC23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9685:MINDY1
gene id: 9685:MINDY1
uniprot id: M3WBV2
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9685:SLC10A7
gene id: 9685:SLC10A7
uniprot id: A0A337SJU6
uniprot id: A0A337SLX6
uniprot id: M3VZM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9685:THNSL1
gene id: 9685:THNSL1
uniprot id: M3X8W6
names: Similarity
messages: Belongs to the threonine synthase family.

9685:SLC25A32
gene id: 9685:SLC25A32
uniprot id: M3W3C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:ADGRG1
gene id: 9685:ADGRG1
uniprot id: A0A5F5XTA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9685:LOC101095395
gene id: 9685:LOC101095395
uniprot id: A0A2I2U2F0
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9685:AGTR2
gene id: 9685:AGTR2
uniprot id: M3WK09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

9685:FTH1
gene id: 9685:FTH1
uniprot id: Q2MHN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

9685:CASP3
gene id: 9685:CASP3
uniprot id: Q8MJU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.
messages: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).
messages: S-nitrosylated on its catalytic site cysteine in unstimulated cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.

9685:ALDH4A1
gene id: 9685:ALDH4A1
uniprot id: A0A337SBS8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9685:HNRNPF
gene id: 9685:HNRNPF
uniprot id: M3XBR2
names: Subcellular Location Annotation
messages: nucleoplasm

9685:EXOC1
gene id: 9685:EXOC1
uniprot id: A0A2I2V317
uniprot id: A0A2I2V3W2
uniprot id: M3WPI1
names: Similarity
messages: Belongs to the SEC3 family.

9685:RFT1
gene id: 9685:RFT1
uniprot id: M3XCV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

9685:RECQL5
gene id: 9685:RECQL5
uniprot id: M3W4M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9685:VSX2
gene id: 9685:VSX2
uniprot id: A0A337SVZ9
names: Subcellular Location Annotation
messages: Nucleus

9685:NUDC
gene id: 9685:NUDC
uniprot id: M3WHP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9685:FLCN
gene id: 9685:FLCN
uniprot id: M3W4J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9685:CCN4
gene id: 9685:CCN4
uniprot id: M3X2T4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:TSC22D4
gene id: 9685:TSC22D4
uniprot id: M3WDY9
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9685:ATP6V1D
gene id: 9685:ATP6V1D
uniprot id: A0A5F5XKK6
uniprot id: M3WEF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9685:ERBIN
gene id: 9685:ERBIN
uniprot id: A0A2I2UIE6
uniprot id: A0A337SCI1
uniprot id: A0A337SWU1
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9685:SPA17
gene id: 9685:SPA17
uniprot id: A0A2I2V0R5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9685:GLE1
gene id: 9685:GLE1
uniprot id: M3W4T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

9685:NAT10
gene id: 9685:NAT10
uniprot id: M3VXR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9685:MAF1
gene id: 9685:MAF1
uniprot id: A0A2I2U9K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

9685:TATDN1
gene id: 9685:TATDN1
uniprot id: A0A2I2U7W8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9685:A2ML1
gene id: 9685:A2ML1
uniprot id: A0A337SNL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9685:SPIN4
gene id: 9685:SPIN4
uniprot id: M3W190
names: Similarity
messages: Belongs to the SPIN/STSY family.

9685:TOP2A
gene id: 9685:TOP2A
uniprot id: M3WBT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9685:LOC101085531
gene id: 9685:LOC101085531
uniprot id: A0A2I2UIV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9685:GUCA2A
gene id: 9685:GUCA2A
uniprot id: M3W5G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9685:LOC102899079
gene id: 9685:LOC102899079
uniprot id: M3WWC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CCT7
gene id: 9685:CCT7
uniprot id: M3WJC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9685:EIF6
gene id: 9685:EIF6
uniprot id: M3W5W5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9685:PKNOX2
gene id: 9685:PKNOX2
uniprot id: M3WLX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9685:FOS
gene id: 9685:FOS
uniprot id: Q8HZP6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Fos subfamily.
messages: Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-233 (By similarity).
messages: Endoplasmic reticulum
messages: Heterodimer; with JUN (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1-binding site (By similarity). Interacts with SMAD3; the interaction is weak even on TGF-beta activation (By similarity). Interacts with MAFB (By similarity). Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with CDS1 and PI4K2A (By similarity). Interacts (via bZIP domain and leucine-zipper region) with the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF) subunits SMARCB1, SMARCC2 and SMARCD1 (By similarity). Interacts (via bZIP domain and leucine-zipper region) with ARID1A (By similarity).
messages: In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the association with endoplasmic reticulum membranes and activation of phospholipid synthesis (By similarity).
messages: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
messages: Nucleus
messages: Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-363 and Ser-375 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-375 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-363 and Ser-375 primes further phosphorylations on Thr-326 and Thr-332 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-233, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-363 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity).
messages: cytosol

9685:MASP2
gene id: 9685:MASP2
uniprot id: M3VU02
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:MCPH1
gene id: 9685:MCPH1
uniprot id: Q6PYB8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

9685:FGF7
gene id: 9685:FGF7
uniprot id: M3WX30
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9685:MCTS1
gene id: 9685:MCTS1
uniprot id: A0A2I2UQ50
uniprot id: A0A2I2URS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9685:EPCAM
gene id: 9685:EPCAM
uniprot id: M3WIV4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
messages: Membrane
messages: tight junction

9685:EXO5
gene id: 9685:EXO5
uniprot id: M3W4K7
names: Similarity
messages: Belongs to the EXO5 family.

9685:AMACR
gene id: 9685:AMACR
uniprot id: M3WPD9
names: Similarity
messages: Belongs to the CoA-transferase III family.

9685:ZNF18
gene id: 9685:ZNF18
uniprot id: A0A2I2UKL4
names: Subcellular Location Annotation
messages: Nucleus

9685:ATP2B1
gene id: 9685:ATP2B1
uniprot id: M3W822
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: synaptic vesicle membrane

9685:ABI1
gene id: 9685:ABI1
uniprot id: A0A2I2U1R0
uniprot id: A0A2I2U302
uniprot id: A0A2I2UPZ5
uniprot id: A0A337SAV3
uniprot id: M3WZB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9685:CA3H2orf68
gene id: 9685:CA3H2orf68
uniprot id: M3X0X7
names: Similarity
messages: Belongs to the UPF0561 family.

9685:SAR1B
gene id: 9685:SAR1B
uniprot id: M3VUK3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9685:P4HA2
gene id: 9685:P4HA2
uniprot id: A0A2I2UQH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9685:ADGRB3
gene id: 9685:ADGRB3
uniprot id: A0A2I2V4L1
names: Subcellular Location Annotation
messages: Membrane

9685:TFRC
gene id: 9685:TFRC
uniprot id: A0A2I2UIM1
uniprot id: Q9MYZ3
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4 (By similarity). Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity).
messages: Melanosome
messages: Membrane
messages: N- and O-glycosylated, phosphorylated and palmitoylated.
messages: Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (By similarity). Stearoylation does not affect iron uptake (By similarity).
messages: Stearoylated.
messages: The YTRF endocytosis motif engages the clathrin-mediated endocytic machinery through adapter protein-2.

9685:CELSR2
gene id: 9685:CELSR2
uniprot id: A0A2I2U7Y3
uniprot id: A0A5F5XJ86
uniprot id: M3WM93
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

9685:LOC101084373
gene id: 9685:LOC101084373
uniprot id: M3WY87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101087741
gene id: 9685:LOC101087741
uniprot id: M3WSW5
names: Subcellular Location Annotation
messages: Cytoplasm

9685:LOC101092919
gene id: 9685:LOC101092919
uniprot id: A0A2I2UIZ5
uniprot id: M3VV34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9685:LOC101081428
gene id: 9685:LOC101081428
uniprot id: M3WA04
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9685:SPTLC3
gene id: 9685:SPTLC3
uniprot id: M3WKG1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9685:LOC101092110
gene id: 9685:LOC101092110
uniprot id: M3X944
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ITGA5
gene id: 9685:ITGA5
uniprot id: M3WCS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9685:CA3H2orf49
gene id: 9685:CA3H2orf49
uniprot id: A0A2I2UNI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9685:ST7
gene id: 9685:ST7
uniprot id: A0A337SGG0
uniprot id: A0M8T0
uniprot id: A0M8T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9685:ZBTB8OS
gene id: 9685:ZBTB8OS
uniprot id: M3VV92
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

9685:LOC105260451
gene id: 9685:LOC105260451
uniprot id: A0A2I2V0W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TEAD2
gene id: 9685:TEAD2
uniprot id: M3VWT4
names: Subcellular Location Annotation
messages: Nucleus

9685:TUBD1
gene id: 9685:TUBD1
uniprot id: M3W0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9685:SSR2
gene id: 9685:SSR2
uniprot id: A0A337SDR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9685:FAM135A
gene id: 9685:FAM135A
uniprot id: A0A2I2UVF7
uniprot id: A0A2I2V0K6
uniprot id: M3WS78
names: Similarity
messages: Belongs to the FAM135 family.

9685:MRPL33
gene id: 9685:MRPL33
uniprot id: A0A2I2UI79
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9685:PAH
gene id: 9685:PAH
uniprot id: A0A337S7G7
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9685:CRH
gene id: 9685:CRH
uniprot id: M3VX86
uniprot id: Q1HCN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9685:ACSF3
gene id: 9685:ACSF3
uniprot id: A0A5F5Y7K3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9685:SLC11A1
gene id: 9685:SLC11A1
uniprot id: M3VYE4
names: Function
names: Similarity
messages: Belongs to the NRAMP family.
messages: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

9685:DDX58
gene id: 9685:DDX58
uniprot id: M3VWD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9685:NUDT7
gene id: 9685:NUDT7
uniprot id: M3WTY8
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9685:SLCO5A1
gene id: 9685:SLCO5A1
uniprot id: M3X4E9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:NGRN
gene id: 9685:NGRN
uniprot id: M3X9U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9685:STX16
gene id: 9685:STX16
uniprot id: A0A2I2UJA1
names: Similarity
messages: Belongs to the syntaxin family.

9685:LOC101082530
gene id: 9685:LOC101082530
uniprot id: M3X5N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:RAD54L2
gene id: 9685:RAD54L2
uniprot id: M3WP42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9685:TENT5A
gene id: 9685:TENT5A
uniprot id: A0A2I2V069
names: Similarity
messages: Belongs to the TENT family.

9685:GRM1
gene id: 9685:GRM1
uniprot id: A0A2I2V2Y5
uniprot id: M3WDB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9685:MEF2C
gene id: 9685:MEF2C
uniprot id: A0A2I2UEL6
uniprot id: A0A2I2UIA4
uniprot id: M3WFD7
names: Subcellular Location Annotation
messages: Nucleus

9685:PDE1C
gene id: 9685:PDE1C
uniprot id: M3VUB1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9685:CDK7
gene id: 9685:CDK7
uniprot id: M3W2X7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9685:RPS27A
gene id: 9685:RPS27A
uniprot id: M3WWF6
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9685:TRPM3
gene id: 9685:TRPM3
uniprot id: A0A2I2UMZ7
names: Subcellular Location Annotation
messages: Membrane

9685:SGMS1
gene id: 9685:SGMS1
uniprot id: M3WLS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9685:PPP2R5B
gene id: 9685:PPP2R5B
uniprot id: A0A5F5XG16
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9685:FRZB
gene id: 9685:FRZB
uniprot id: M3WJ69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9685:CHRM4
gene id: 9685:CHRM4
uniprot id: M3XFA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9685:SGCE
gene id: 9685:SGCE
uniprot id: A0A2I2V396
uniprot id: M3X4B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Golgi apparatus
messages: cytoskeleton
messages: dendrite
messages: sarcolemma

9685:SSH3
gene id: 9685:SSH3
uniprot id: A0A5F5XF23
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9685:ATP5IF1
gene id: 9685:ATP5IF1
uniprot id: M3WIS8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9685:RPS15A
gene id: 9685:RPS15A
uniprot id: M3WDL6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.

9685:WNT3
gene id: 9685:WNT3
uniprot id: M3WFT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9685:STAC3
gene id: 9685:STAC3
uniprot id: M3VU94
names: Subcellular Location Annotation
messages: sarcolemma

9685:DMTN
gene id: 9685:DMTN
uniprot id: A0A337RXR9
uniprot id: A0A337SPC7
uniprot id: M3WHZ4
names: Subcellular Location Annotation
messages: Cytoplasm

9685:KCNJ12
gene id: 9685:KCNJ12
uniprot id: A0A337RXG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

9685:MAS1
gene id: 9685:MAS1
uniprot id: M3VZ92
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:LOC101082945
gene id: 9685:LOC101082945
uniprot id: M3WR99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:SLC13A2
gene id: 9685:SLC13A2
uniprot id: M3W995
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9685:CUL4B
gene id: 9685:CUL4B
uniprot id: A0A2I2U2R4
uniprot id: A0A337SMN1
uniprot id: Q1WF15
names: Similarity
messages: Belongs to the cullin family.

9685:WDR24
gene id: 9685:WDR24
uniprot id: A0A2I2UZB6
names: Similarity
messages: Belongs to the WD repeat WDR24 family.

9685:SUPT16H
gene id: 9685:SUPT16H
uniprot id: M3WJL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9685:FDXR
gene id: 9685:FDXR
uniprot id: A0A337SC14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

9685:ALG6
gene id: 9685:ALG6
uniprot id: M3X9T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:TOMM5
gene id: 9685:TOMM5
uniprot id: A0A2I2UNL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

9685:LALBA
gene id: 9685:LALBA
uniprot id: A0A5F5XQC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9685:PIP
gene id: 9685:PIP
uniprot id: A0A337SBR4
names: Similarity
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.

9685:DCAF13
gene id: 9685:DCAF13
uniprot id: M3WYT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

9685:B3GNT2
gene id: 9685:B3GNT2
uniprot id: M3WAQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:LOC101080954
gene id: 9685:LOC101080954
uniprot id: A0A2I2UH17
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9685:RASGRP3
gene id: 9685:RASGRP3
uniprot id: M3WBU3
names: Similarity
messages: Belongs to the RASGRP family.

9685:PPM1L
gene id: 9685:PPM1L
uniprot id: M3X458
names: Similarity
messages: Belongs to the PP2C family.

9685:CPXM1
gene id: 9685:CPXM1
uniprot id: M3WKR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9685:VPS18
gene id: 9685:VPS18
uniprot id: M3WL77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9685:LOC101098145
gene id: 9685:LOC101098145
uniprot id: M3X301
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:AQP11
gene id: 9685:AQP11
uniprot id: M3W7R2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:TK2
gene id: 9685:TK2
uniprot id: A0A337SM65
names: Similarity
messages: Belongs to the DCK/DGK family.

9685:TES
gene id: 9685:TES
uniprot id: A0M8S5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

9685:SMAD4
gene id: 9685:SMAD4
uniprot id: A0A2I2UFR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9685:MECOM
gene id: 9685:MECOM
uniprot id: A0A2I2UNB9
uniprot id: A0A337SBC4
names: Subcellular Location Annotation
messages: Nucleus

9685:AGO3
gene id: 9685:AGO3
uniprot id: M3WVQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9685:LOC101096784
gene id: 9685:LOC101096784
uniprot id: M3WDA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GLYAT
gene id: 9685:GLYAT
uniprot id: M3WPY7
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9685:PDLIM3
gene id: 9685:PDLIM3
uniprot id: A0A2I2U6I6
uniprot id: M3X5W3
names: Subcellular Location Annotation
messages: Z line

9685:ZBED9
gene id: 9685:ZBED9
uniprot id: M3X5J7
names: Subcellular Location Annotation
messages: Nucleus

9685:SCAMP2
gene id: 9685:SCAMP2
uniprot id: A0A5F5Y5X9
uniprot id: M3VUL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9685:TMEM183A
gene id: 9685:TMEM183A
uniprot id: M3WI85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

9685:MANEA
gene id: 9685:MANEA
uniprot id: A0A2I2UKA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:METTL26
gene id: 9685:METTL26
uniprot id: M3X3I7
names: Similarity
messages: Belongs to the UPF0585 family.

9685:LOC101081371
gene id: 9685:LOC101081371
uniprot id: A0A7R8C3W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9685:COX7B2
gene id: 9685:COX7B2
uniprot id: A0A2I2UWQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9685:LOC101084154
gene id: 9685:LOC101084154
uniprot id: A0A2I2V102
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9685:SLITRK1
gene id: 9685:SLITRK1
uniprot id: M3VYI8
names: Similarity
messages: Belongs to the SLITRK family.

9685:NMNAT1
gene id: 9685:NMNAT1
uniprot id: A0A5F5Y742
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9685:LOC101101603
gene id: 9685:LOC101101603
uniprot id: A0A337SQ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IGFL family.
messages: Secreted

9685:IRF4
gene id: 9685:IRF4
uniprot id: A0A2I2V3D7
uniprot id: M3XD58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:DLK2
gene id: 9685:DLK2
uniprot id: M3X710
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LOC101086751
gene id: 9685:LOC101086751
uniprot id: M3X205
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:FAXC
gene id: 9685:FAXC
uniprot id: M3W787
names: Similarity
messages: Belongs to the FAX family.

9685:DDX6
gene id: 9685:DDX6
uniprot id: M3WXQ4
names: Similarity
messages: Belongs to the DEAD box helicase family.

9685:LOC105261012
gene id: 9685:LOC105261012
uniprot id: A0A5F5XH25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:F12
gene id: 9685:F12
uniprot id: D0F0C7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:MADD
gene id: 9685:MADD
uniprot id: A0A2I2TZX4
uniprot id: A0A2I2U987
uniprot id: A0A5F5XII2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9685:NTAQ1
gene id: 9685:NTAQ1
uniprot id: A0A337S6K4
uniprot id: M3WR90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9685:RANBP10
gene id: 9685:RANBP10
uniprot id: B5LX41
names: Similarity
messages: Belongs to the RANBP9/10 family.

9685:GTF2E2
gene id: 9685:GTF2E2
uniprot id: M3X5G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9685:PIWIL2
gene id: 9685:PIWIL2
uniprot id: M3WHZ7
names: Similarity
messages: Belongs to the argonaute family.

9685:HNRNPH1
gene id: 9685:HNRNPH1
uniprot id: A0A2I2UXE4
uniprot id: A0A337SDC1
uniprot id: A0A337SQ04
names: Subcellular Location Annotation
messages: nucleoplasm

9685:BAK1
gene id: 9685:BAK1
uniprot id: A0A2I2UUV3
names: Similarity
messages: Belongs to the Bcl-2 family.

9685:FXYD7
gene id: 9685:FXYD7
uniprot id: A0A337SRM9
names: Similarity
messages: Belongs to the FXYD family.

9685:PPOX
gene id: 9685:PPOX
uniprot id: M3WN79
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9685:MTERF3
gene id: 9685:MTERF3
uniprot id: M3WQZ6
names: Similarity
messages: Belongs to the mTERF family.

9685:OAZ2
gene id: 9685:OAZ2
uniprot id: M3WEX4
names: Similarity
messages: Belongs to the ODC antizyme family.

9685:ADNP
gene id: 9685:ADNP
uniprot id: M3XE38
names: Subcellular Location Annotation
messages: Nucleus

9685:DTNA
gene id: 9685:DTNA
uniprot id: A0A2I2U492
uniprot id: A0A2I2UFA8
uniprot id: A0A337SSP0
uniprot id: M3WF72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9685:FAH
gene id: 9685:FAH
uniprot id: A0A5F5XI98
uniprot id: A0A5F5XYE6
names: Similarity
messages: Belongs to the FAH family.

9685:LSM8
gene id: 9685:LSM8
uniprot id: A0A2I2UY34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9685:HMGCLL1
gene id: 9685:HMGCLL1
uniprot id: M3W6I1
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

9685:CLVS2
gene id: 9685:CLVS2
uniprot id: M3WE10
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9685:MFAP2
gene id: 9685:MFAP2
uniprot id: M3WVF4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9685:LOC101089023
gene id: 9685:LOC101089023
uniprot id: A0A2I2UAP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:DGKA
gene id: 9685:DGKA
uniprot id: M3WJU2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9685:UGCG
gene id: 9685:UGCG
uniprot id: M3X3K9
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9685:CYRIA
gene id: 9685:CYRIA
uniprot id: A0A5F5XX33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9685:EPHA4
gene id: 9685:EPHA4
uniprot id: A0A2I2UV62
names: Subcellular Location Annotation
messages: Membrane

9685:PPIL3
gene id: 9685:PPIL3
uniprot id: M3W3Y9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9685:DPP3
gene id: 9685:DPP3
uniprot id: A0A2I2UBQ8
uniprot id: A0A2I2UDP9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

9685:CMAS
gene id: 9685:CMAS
uniprot id: M3WCA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

9685:PTER
gene id: 9685:PTER
uniprot id: M3WJ23
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LOC101095308
gene id: 9685:LOC101095308
uniprot id: M3WRG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101097958
gene id: 9685:LOC101097958
uniprot id: M3WYC0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:BPGM
gene id: 9685:BPGM
uniprot id: M3WX85
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9685:HSD17B6
gene id: 9685:HSD17B6
uniprot id: M3VVL6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:SEC24A
gene id: 9685:SEC24A
uniprot id: A0A2I2UJD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9685:CRYBB1
gene id: 9685:CRYBB1
uniprot id: M3WDS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9685:CNKSR2
gene id: 9685:CNKSR2
uniprot id: A0A2I2U5T2
names: Similarity
messages: Belongs to the CNKSR family.

9685:TMED1
gene id: 9685:TMED1
uniprot id: A0A2I2U5B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9685:ARPC5
gene id: 9685:ARPC5
uniprot id: M3WMY0
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9685:BHMT
gene id: 9685:BHMT
uniprot id: M3XCT4
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9685:FELCATV1R7
gene id: 9685:FELCATV1R7
uniprot id: M3X8C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:TIMM17A
gene id: 9685:TIMM17A
uniprot id: M3WWG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9685:POLR2K
gene id: 9685:POLR2K
uniprot id: M3VXF4
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9685:TNP2
gene id: 9685:TNP2
uniprot id: B3LF33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Nucleus
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.

9685:USH2A
gene id: 9685:USH2A
uniprot id: A0A2I2U6D9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LOC101100152
gene id: 9685:LOC101100152
uniprot id: M3WVE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ECSIT
gene id: 9685:ECSIT
uniprot id: M3W343
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

9685:SFR1
gene id: 9685:SFR1
uniprot id: M3XBS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9685:DIAPH3
gene id: 9685:DIAPH3
uniprot id: A0A2I2U9X5
uniprot id: M3WQG3
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

9685:DUSP10
gene id: 9685:DUSP10
uniprot id: M3WM38
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9685:BPNT1
gene id: 9685:BPNT1
uniprot id: A0A2I2UBM3
uniprot id: M3XEI7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9685:AP1B1
gene id: 9685:AP1B1
uniprot id: A0A337S3J7
uniprot id: M3WY66
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9685:DHH
gene id: 9685:DHH
uniprot id: A0A2I2V005
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9685:DCLRE1A
gene id: 9685:DCLRE1A
uniprot id: M3WFU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9685:TPD52L2
gene id: 9685:TPD52L2
uniprot id: A0A2I2U356
uniprot id: A0A2I2UBL6
uniprot id: A0A337S938
uniprot id: A0A5F5XEW5
uniprot id: M3VW51
names: Similarity
messages: Belongs to the TPD52 family.

9685:ATP1B2
gene id: 9685:ATP1B2
uniprot id: A0A5F5XVM0
uniprot id: A0A5F5Y2L4
uniprot id: M3WBS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9685:UCP2
gene id: 9685:UCP2
uniprot id: M3W3C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9685:TYMS
gene id: 9685:TYMS
uniprot id: M3WB14
names: Similarity
messages: Belongs to the thymidylate synthase family.

9685:CREB3L3
gene id: 9685:CREB3L3
uniprot id: M3WK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:DYRK1A
gene id: 9685:DYRK1A
uniprot id: A0A337RZ15
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9685:POLR2J
gene id: 9685:POLR2J
uniprot id: A0A2I2U599
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9685:CAVIN1
gene id: 9685:CAVIN1
uniprot id: M3X6G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9685:CHST3
gene id: 9685:CHST3
uniprot id: M3WI48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9685:LOC101098354
gene id: 9685:LOC101098354
uniprot id: M3X164
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:KRT82
gene id: 9685:KRT82
uniprot id: M3VUF5
names: Similarity
messages: Belongs to the intermediate filament family.

9685:RPL24
gene id: 9685:RPL24
uniprot id: Q66WF5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Mono-ADP-ribosylation at Glu-4 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.

9685:ZDHHC13
gene id: 9685:ZDHHC13
uniprot id: M3WDR7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:TGFB1
gene id: 9685:TGFB1
uniprot id: M3W421
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

9685:SLC17A6
gene id: 9685:SLC17A6
uniprot id: M3WQB5
names: Subcellular Location Annotation
messages: Membrane

9685:MCM3
gene id: 9685:MCM3
uniprot id: M3X046
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9685:LOC101101283
gene id: 9685:LOC101101283
uniprot id: A0A5F5XXM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:F8
gene id: 9685:F8
uniprot id: A0A5F5XH53
names: Similarity
messages: Belongs to the multicopper oxidase family.

9685:BRK1
gene id: 9685:BRK1
uniprot id: M3WEQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: cytoskeleton

9685:VIPR2
gene id: 9685:VIPR2
uniprot id: M3WAP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9685:THY1
gene id: 9685:THY1
uniprot id: A0A2I2UGV7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
messages: Membrane

9685:MSH6
gene id: 9685:MSH6
uniprot id: A0A5F5XGN9
uniprot id: M3W729
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

9685:SLC12A1
gene id: 9685:SLC12A1
uniprot id: A0A2I2UGY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9685:TASP1
gene id: 9685:TASP1
uniprot id: A0A337SL99
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9685:UTP11
gene id: 9685:UTP11
uniprot id: M3WEC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9685:METAP2
gene id: 9685:METAP2
uniprot id: A0A2I2UQQ9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9685:EMG1
gene id: 9685:EMG1
uniprot id: M3W1X7
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9685:RECQL
gene id: 9685:RECQL
uniprot id: M3WQ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9685:KCNS3
gene id: 9685:KCNS3
uniprot id: M3WKD5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:DERL2
gene id: 9685:DERL2
uniprot id: M3X8Q0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:PNRC1
gene id: 9685:PNRC1
uniprot id: A0A2I2V057
names: Subcellular Location Annotation
messages: Nucleus

9685:FELCATV1R2
gene id: 9685:FELCATV1R2
uniprot id: M3XG92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:DUSP4
gene id: 9685:DUSP4
uniprot id: M3X8R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9685:ECI1
gene id: 9685:ECI1
uniprot id: M3W858
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9685:SIDT2
gene id: 9685:SIDT2
uniprot id: M3WJ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9685:ZDHHC24
gene id: 9685:ZDHHC24
uniprot id: M3XCJ0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:SLC6A15
gene id: 9685:SLC6A15
uniprot id: M3X326
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

9685:TRADD
gene id: 9685:TRADD
uniprot id: A0A337S5N8
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

9685:IDH3A
gene id: 9685:IDH3A
uniprot id: M3WDF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9685:WARS1
gene id: 9685:WARS1
uniprot id: A0A2I2UA14
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9685:DPAGT1
gene id: 9685:DPAGT1
uniprot id: M3VW37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:MAK16
gene id: 9685:MAK16
uniprot id: A0A2I2U3N6
names: Similarity
messages: Belongs to the MAK16 family.

9685:SUB1
gene id: 9685:SUB1
uniprot id: A0A2I2UN36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9685:IL26
gene id: 9685:IL26
uniprot id: M3WDI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9685:CCDC39
gene id: 9685:CCDC39
uniprot id: M3WQK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: cilium axoneme

9685:GAB2
gene id: 9685:GAB2
uniprot id: M3W7R8
names: Similarity
messages: Belongs to the GAB family.

9685:CDC42EP3
gene id: 9685:CDC42EP3
uniprot id: M3XAY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9685:QTRT2
gene id: 9685:QTRT2
uniprot id: M3XBM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9685:GPR182
gene id: 9685:GPR182
uniprot id: A0A5F5XV40
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:OPN1LW
gene id: 9685:OPN1LW
uniprot id: O18913
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: The three color pigments are found in the cone photoreceptor cells. Expressed in retina (PubMed:10511567).
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

9685:COX16
gene id: 9685:COX16
uniprot id: A0A2I2UNG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

9685:CLTB
gene id: 9685:CLTB
uniprot id: A0A2I2UNI9
uniprot id: M3X8N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9685:ERMAP
gene id: 9685:ERMAP
uniprot id: M3W0F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9685:CACUL1
gene id: 9685:CACUL1
uniprot id: A0A2I2UFD8
names: Similarity
messages: Belongs to the cullin family.

9685:STAG3
gene id: 9685:STAG3
uniprot id: A0A5F5XVY9
uniprot id: M3X0I3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9685:TOMM40L
gene id: 9685:TOMM40L
uniprot id: A0A2I2ULV8
uniprot id: M3WN88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9685:AGL
gene id: 9685:AGL
uniprot id: M3X112
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

9685:SRP54
gene id: 9685:SRP54
uniprot id: M3WSB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle

9685:TMEM43
gene id: 9685:TMEM43
uniprot id: M3VXF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

9685:ACSF2
gene id: 9685:ACSF2
uniprot id: M3WGR0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9685:CNTF
gene id: 9685:CNTF
uniprot id: A0A2I2UWM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9685:UMPS
gene id: 9685:UMPS
uniprot id: M3W6I6
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9685:SDHAF2
gene id: 9685:SDHAF2
uniprot id: M3WJA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9685:LOC101084183
gene id: 9685:LOC101084183
uniprot id: A0A337S3B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:TMEM63B
gene id: 9685:TMEM63B
uniprot id: A0A2I2UAS1
uniprot id: M3WC22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9685:PDE6B
gene id: 9685:PDE6B
uniprot id: M3W967
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9685:PDE4C
gene id: 9685:PDE4C
uniprot id: A0A2I2V4E3
uniprot id: A0A337SH66
uniprot id: M3W7V5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9685:P2RX1
gene id: 9685:P2RX1
uniprot id: M3W8N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9685:PLCB4
gene id: 9685:PLCB4
uniprot id: A0A5F5XZA9
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9685:LOC101085238
gene id: 9685:LOC101085238
uniprot id: M3XFG9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101099214
gene id: 9685:LOC101099214
uniprot id: M3X2L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:ZNF500
gene id: 9685:ZNF500
uniprot id: A0A2I2UNI5
names: Subcellular Location Annotation
messages: Nucleus

9685:LOC101083355
gene id: 9685:LOC101083355
uniprot id: M3WZ94
names: Similarity
messages: Belongs to the peptidase A1 family.

9685:ZP4
gene id: 9685:ZP4
uniprot id: P48834
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
messages: Expressed in oocytes.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9685:CYP19A1
gene id: 9685:CYP19A1
uniprot id: K7NAJ2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9685:EDNRB
gene id: 9685:EDNRB
uniprot id: A0A337SDI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:NPM1
gene id: 9685:NPM1
uniprot id: M3X673
names: Similarity
messages: Belongs to the nucleoplasmin family.

9685:LY75
gene id: 9685:LY75
uniprot id: M3W724
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:SLC44A4
gene id: 9685:SLC44A4
uniprot id: M3W2B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9685:HNRNPC
gene id: 9685:HNRNPC
uniprot id: A0A337SDT4
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9685:ACYP2
gene id: 9685:ACYP2
uniprot id: A0A337S1E5
names: Similarity
messages: Belongs to the acylphosphatase family.

9685:SCMH1
gene id: 9685:SCMH1
uniprot id: M3WMD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9685:LOC101089895
gene id: 9685:LOC101089895
uniprot id: A0A5F5XV57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CXCL13
gene id: 9685:CXCL13
uniprot id: A0A2I2U3A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9685:RAB3D
gene id: 9685:RAB3D
uniprot id: M3VYK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9685:CREB5
gene id: 9685:CREB5
uniprot id: A0A2I2ULB1
uniprot id: A0A2I2UYM1
uniprot id: M3WN95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

9685:C8G
gene id: 9685:C8G
uniprot id: M3VUN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9685:CRYAA
gene id: 9685:CRYAA
uniprot id: P68282
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-70 may increase chaperone activity.
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA (By similarity).
messages: Nucleus
messages: Undergoes age-dependent proteolytical cleavage at the C-terminus.

9685:SRFBP1
gene id: 9685:SRFBP1
uniprot id: A0A2I2UHN1
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9685:USP2
gene id: 9685:USP2
uniprot id: A0A2I2URI0
uniprot id: A0A337S1E0
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9685:KRTCAP3
gene id: 9685:KRTCAP3
uniprot id: M3W3L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9685:ENPEP
gene id: 9685:ENPEP
uniprot id: M3VU18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Membrane
messages: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

9685:CCL8
gene id: 9685:CCL8
uniprot id: M3WJ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:ADCK2
gene id: 9685:ADCK2
uniprot id: A0A5F5XR47
uniprot id: M3X3T3
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9685:EIF2S1
gene id: 9685:EIF2S1
uniprot id: M3WYU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9685:TMC5
gene id: 9685:TMC5
uniprot id: A0A2I2U5N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9685:BBS4
gene id: 9685:BBS4
uniprot id: A0A2I2UKS6
uniprot id: A0A5F5XST8
uniprot id: M3XFE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

9685:LIMD1
gene id: 9685:LIMD1
uniprot id: M3WZV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Nucleus

9685:ARL14
gene id: 9685:ARL14
uniprot id: M3W2M8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9685:PSME3
gene id: 9685:PSME3
uniprot id: A0A337SKZ6
names: Similarity
messages: Belongs to the PA28 family.

9685:CORO6
gene id: 9685:CORO6
uniprot id: A0A2I2UR48
uniprot id: A0A2I2UVQ7
names: Similarity
messages: Belongs to the WD repeat coronin family.

9685:SFRP1
gene id: 9685:SFRP1
uniprot id: A0A2I2UR94
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:TMEM45B
gene id: 9685:TMEM45B
uniprot id: A0A2I2U2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9685:IL23A
gene id: 9685:IL23A
uniprot id: M3WG71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9685:ATL1
gene id: 9685:ATL1
uniprot id: M3WXA3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9685:POLM
gene id: 9685:POLM
uniprot id: M3X1D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9685:LOC101087098
gene id: 9685:LOC101087098
uniprot id: M3X3F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CPA6
gene id: 9685:CPA6
uniprot id: M3W7E0
names: Similarity
messages: Belongs to the peptidase M14 family.

9685:LOC101087322
gene id: 9685:LOC101087322
uniprot id: A0A5F5XMI9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9685:MAP2K5
gene id: 9685:MAP2K5
uniprot id: A0A337SCD1
uniprot id: A0A337STZ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:VIL1
gene id: 9685:VIL1
uniprot id: M3VYE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: filopodium tip
messages: lamellipodium
messages: microvillus
messages: ruffle

9685:CSE1L
gene id: 9685:CSE1L
uniprot id: M3VWN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9685:NFIB
gene id: 9685:NFIB
uniprot id: A0A5F5XLX9
uniprot id: A0A5F5XMA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9685:CCM2
gene id: 9685:CCM2
uniprot id: A0A2I2UB54
uniprot id: A0A337SQK1
names: Similarity
messages: Belongs to the CCM2 family.

9685:PSIP1
gene id: 9685:PSIP1
uniprot id: Q66T72
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts (via IBD domain) with feline immunodeficiency virus (FIV) integrase (IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome.
messages: Belongs to the HDGF family.
messages: Citrullinated by PADI4.
messages: Monomer (By similarity). Interacts with IFRD1/PC4 (By similarity). Interacts (via IBD domain) with POGZ (via IBM motif) and CDCA7L (via IBM motifs) (By similarity). Interacts (via IBD domain) with KMT2A (via IBM motifs) with a moderate affinity whereas interacts with the KMT2A-MEN1 complex with a greater affinity; MEN1 enhances interaction of KMT2A with PSIP1 (By similarity). Interacts (via IBD domain) with IWS1 (via IBM motif), MED1 (via IBM motif) and DBF4 (via IBM motifs) (By similarity).
messages: Nucleus
messages: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).

9685:SLC45A2
gene id: 9685:SLC45A2
uniprot id: B2ZHD7
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101097969
gene id: 9685:LOC101097969
uniprot id: M3VV19
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:RBM8A
gene id: 9685:RBM8A
uniprot id: A0A2I2V431
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9685:YIPF5
gene id: 9685:YIPF5
uniprot id: M3XCX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9685:LBH
gene id: 9685:LBH
uniprot id: A0A2I2UXT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9685:ANKS3
gene id: 9685:ANKS3
uniprot id: M3W2F3
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9685:DCK
gene id: 9685:DCK
uniprot id: M3X133
names: Similarity
messages: Belongs to the DCK/DGK family.

9685:FSCN3
gene id: 9685:FSCN3
uniprot id: M3W455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9685:SELE
gene id: 9685:SELE
uniprot id: A0A2I2TZY2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:LOC101099332
gene id: 9685:LOC101099332
uniprot id: A0A2I2V171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9685:ITM2A
gene id: 9685:ITM2A
uniprot id: A0A5F5XX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9685:CA1H5orf22
gene id: 9685:CA1H5orf22
uniprot id: A0A2I2ULY9
names: Similarity
messages: Belongs to the UPF0489 family.

9685:PNLIPRP3
gene id: 9685:PNLIPRP3
uniprot id: A0A337SVU9
uniprot id: M3XDN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9685:DUSP2
gene id: 9685:DUSP2
uniprot id: M3WDR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9685:CLN8
gene id: 9685:CLN8
uniprot id: M3XG88
names: Subcellular Location Annotation
messages: Membrane

9685:CD2
gene id: 9685:CD2
uniprot id: Q8WNV8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:RBP4
gene id: 9685:RBP4
uniprot id: M5AXY1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Highly expressed in liver. Also expressed in adipose tissue (PubMed:23719693). Expressed by endometrium from days 16-25 and by unattached chorioallantois from days 30-36 during pregnancy (PubMed:2015342).
messages: Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.
messages: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
messages: Secreted
messages: Secreted in fetal fluids. Present on day 25, decreases from days 30-39, and disappears by day 50. Expressed by blastocysts on days 10-25 during prenatal development, but disappears by day 50.

9685:PTPN2
gene id: 9685:PTPN2
uniprot id: A0A337S5B6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9685:WSCD2
gene id: 9685:WSCD2
uniprot id: M3WE46
names: Similarity
messages: Belongs to the WSCD family.

9685:ASIC2
gene id: 9685:ASIC2
uniprot id: M3WNP4
names: Subcellular Location Annotation
messages: Membrane

9685:EVL
gene id: 9685:EVL
uniprot id: A0A5F5XI87
uniprot id: A0A5F5XWN3
uniprot id: M3XED8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: lamellipodium
messages: stress fiber

9685:ZDHHC12
gene id: 9685:ZDHHC12
uniprot id: M3W4U2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:IFRD2
gene id: 9685:IFRD2
uniprot id: M3W6X4
names: Similarity
messages: Belongs to the IFRD family.

9685:GK
gene id: 9685:GK
uniprot id: A0A337SSR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9685:BMP15
gene id: 9685:BMP15
uniprot id: C7EWM2
names: Similarity
messages: Belongs to the TGF-beta family.

9685:QPCT
gene id: 9685:QPCT
uniprot id: M3WST2
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9685:LOC101084205
gene id: 9685:LOC101084205
uniprot id: A0A337S4Y2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LOC101080332
gene id: 9685:LOC101080332
uniprot id: A0A341ZMG9
names: Similarity
messages: Belongs to the NipSnap family.

9685:HPS6
gene id: 9685:HPS6
uniprot id: A0A5F5XUW1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9685:GSK3B
gene id: 9685:GSK3B
uniprot id: A0A2I2U7S7
uniprot id: A0A337S9S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

9685:CHRNA6
gene id: 9685:CHRNA6
uniprot id: M3X1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:DNPEP
gene id: 9685:DNPEP
uniprot id: A0A337S8S9
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9685:IFITM5
gene id: 9685:IFITM5
uniprot id: M3WXK5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9685:DNASE1L1
gene id: 9685:DNASE1L1
uniprot id: M3WF15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Nucleus envelope
messages: Zymogen granule

9685:FGR
gene id: 9685:FGR
uniprot id: M3W8J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9685:GADL1
gene id: 9685:GADL1
uniprot id: M3XB58
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9685:SAMD8
gene id: 9685:SAMD8
uniprot id: A0A2I2V437
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9685:AWAT2
gene id: 9685:AWAT2
uniprot id: A0A2I2ULD0
uniprot id: M3WA56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9685:OPA1
gene id: 9685:OPA1
uniprot id: A0A2I2UF97
uniprot id: A0A337SN50
uniprot id: M3VV89
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9685:EYA4
gene id: 9685:EYA4
uniprot id: A0A337SUI7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus

9685:CLIC2
gene id: 9685:CLIC2
uniprot id: A0A2I2TZW5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9685:C4BPB
gene id: 9685:C4BPB
uniprot id: M3WJK2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:SLC26A2
gene id: 9685:SLC26A2
uniprot id: M3WWH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

9685:HMBOX1
gene id: 9685:HMBOX1
uniprot id: A0A2I2UYV9
uniprot id: M3XCJ7
names: Subcellular Location Annotation
messages: Nucleus

9685:FAM83A
gene id: 9685:FAM83A
uniprot id: A0A337RT72
names: Similarity
messages: Belongs to the FAM83 family.

9685:HYLS1
gene id: 9685:HYLS1
uniprot id: A0A337SEI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

9685:CCL24
gene id: 9685:CCL24
uniprot id: M3WYH2
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9685:ATXN3
gene id: 9685:ATXN3
uniprot id: A0A337SWI4
uniprot id: M3WT23
names: Subcellular Location Annotation
messages: Nucleus

9685:B3GNT4
gene id: 9685:B3GNT4
uniprot id: M3WGC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9685:SLC2A6
gene id: 9685:SLC2A6
uniprot id: A0A337S6P7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9685:DHCR7
gene id: 9685:DHCR7
uniprot id: M3W1L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9685:KEF43 p12
gene id: 9685:KEF43_p12
uniprot id: P48905
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9685:STX10
gene id: 9685:STX10
uniprot id: M3VUV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9685:KCNJ8
gene id: 9685:KCNJ8
uniprot id: M3WS09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9685:CD164L2
gene id: 9685:CD164L2
uniprot id: A0A337S0G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9685:PA2G4
gene id: 9685:PA2G4
uniprot id: M3WLH5
names: Similarity
messages: Belongs to the peptidase M24 family.

9685:LOC101080323
gene id: 9685:LOC101080323
uniprot id: A0A2I2UR57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:PERP
gene id: 9685:PERP
uniprot id: M3WY23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9685:MFSD1
gene id: 9685:MFSD1
uniprot id: A0A337SHA9
names: Subcellular Location Annotation
messages: Membrane

9685:DHRS7B
gene id: 9685:DHRS7B
uniprot id: A0A337SKY0
uniprot id: M3WLF5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9685:CCNO
gene id: 9685:CCNO
uniprot id: M3XG04
names: Similarity
messages: Belongs to the cyclin family.

9685:PRKAB1
gene id: 9685:PRKAB1
uniprot id: M3VVN1
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9685:SPI1
gene id: 9685:SPI1
uniprot id: M3VYP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:RING1
gene id: 9685:RING1
uniprot id: M3W1D9
names: Function
names: Subcellular Location Annotation
messages: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
messages: Nucleus speckle

9685:CHDH
gene id: 9685:CHDH
uniprot id: M3W4E5
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

9685:MAP1LC3A
gene id: 9685:MAP1LC3A
uniprot id: M3XB56
names: Similarity
messages: Belongs to the ATG8 family.

9685:RIOK2
gene id: 9685:RIOK2
uniprot id: M3X9L1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9685:IRF5
gene id: 9685:IRF5
uniprot id: M3VVQ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:MON1B
gene id: 9685:MON1B
uniprot id: M3W1K5
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9685:UBE2K
gene id: 9685:UBE2K
uniprot id: A0A2I2UNS7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9685:LOC101089699
gene id: 9685:LOC101089699
uniprot id: M3WXN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:HEPHL1
gene id: 9685:HEPHL1
uniprot id: M3WL87
names: Similarity
messages: Belongs to the multicopper oxidase family.

9685:SLC25A31
gene id: 9685:SLC25A31
uniprot id: M3W759
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9685:FAM83B
gene id: 9685:FAM83B
uniprot id: M3WIV0
names: Similarity
messages: Belongs to the FAM83 family.

9685:OGFOD1
gene id: 9685:OGFOD1
uniprot id: M3WA01
names: Similarity
messages: Belongs to the TPA1 family.

9685:RAB5IF
gene id: 9685:RAB5IF
uniprot id: A0A337S247
uniprot id: M3X6D8
names: Subcellular Location Annotation
messages: Membrane

9685:LOC101094108
gene id: 9685:LOC101094108
uniprot id: A0A2I2U006
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9685:P2RX7
gene id: 9685:P2RX7
uniprot id: M3WGZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9685:COQ10B
gene id: 9685:COQ10B
uniprot id: M3X968
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9685:PADI3
gene id: 9685:PADI3
uniprot id: A0A2I2U4T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9685:ROMO1
gene id: 9685:ROMO1
uniprot id: M3VZZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9685:INPP5K
gene id: 9685:INPP5K
uniprot id: M3W5M3
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9685:LOC101094730
gene id: 9685:LOC101094730
uniprot id: M3X5N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9685:SLC24A2
gene id: 9685:SLC24A2
uniprot id: A0A5F5XJB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9685:CUX1
gene id: 9685:CUX1
uniprot id: A0A2I2U192
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Golgi apparatus membrane
messages: Membrane

9685:CAPN11
gene id: 9685:CAPN11
uniprot id: A0A2I2U7E5
names: Similarity
messages: Belongs to the peptidase C2 family.

9685:MGST1
gene id: 9685:MGST1
uniprot id: M3WUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9685:CXCL12
gene id: 9685:CXCL12
uniprot id: A0A2I2U9C3
uniprot id: O62657
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells.
messages: Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of ACKR3. Interacts with integrin subunit ITGB3 (via the allosteric site (site 2)). Interacts with TNFAIP6 (via Link domain).
messages: Secreted

9685:CLCN4
gene id: 9685:CLCN4
uniprot id: M3X4P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9685:CDH1
gene id: 9685:CDH1
uniprot id: A0A337SG59
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
messages: Membrane
messages: trans-Golgi network

9685:BLMH
gene id: 9685:BLMH
uniprot id: M3W1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9685:MSN
gene id: 9685:MSN
uniprot id: M3WJI8
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9685:SPAG7
gene id: 9685:SPAG7
uniprot id: A0A337SC91
names: Subcellular Location Annotation
messages: Nucleus

9685:SEMA4F
gene id: 9685:SEMA4F
uniprot id: A0A2I2UFC3
uniprot id: A0A337SKM0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:MAP3K13
gene id: 9685:MAP3K13
uniprot id: M3XGD4
names: Function
names: Similarity
messages: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9685:KRT222
gene id: 9685:KRT222
uniprot id: M3WNT7
names: Similarity
messages: Belongs to the intermediate filament family.

9685:SMARCA4
gene id: 9685:SMARCA4
uniprot id: A0A2I2UID9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9685:LOC101085573
gene id: 9685:LOC101085573
uniprot id: A0A5F5XZE0
names: Subcellular Location Annotation
messages: Secreted

9685:LOC101091946
gene id: 9685:LOC101091946
uniprot id: M3WYR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CAMK1D
gene id: 9685:CAMK1D
uniprot id: A0A5F5XXT7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:CTH
gene id: 9685:CTH
uniprot id: M3WGZ1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9685:GSTA4
gene id: 9685:GSTA4
uniprot id: A0A2I2URN5
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9685:LOC101095924
gene id: 9685:LOC101095924
uniprot id: A0A337SEV0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9685:BSX
gene id: 9685:BSX
uniprot id: M3W5J1
names: Subcellular Location Annotation
messages: Nucleus

9685:GPR39
gene id: 9685:GPR39
uniprot id: M3VTY6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:GPD1
gene id: 9685:GPD1
uniprot id: M3WBH7
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9685:LOC101084720
gene id: 9685:LOC101084720
uniprot id: A0A5F5XEK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:FGGY
gene id: 9685:FGGY
uniprot id: A0A337S4I8
uniprot id: A0A337SGJ6
names: Similarity
messages: Belongs to the FGGY kinase family.

9685:RFC5
gene id: 9685:RFC5
uniprot id: M3VY75
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9685:PLXNB2
gene id: 9685:PLXNB2
uniprot id: M3WG01
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CYP26B1
gene id: 9685:CYP26B1
uniprot id: M3WYV1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9685:SMPDL3B
gene id: 9685:SMPDL3B
uniprot id: M3W0A7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9685:ELF3
gene id: 9685:ELF3
uniprot id: M3VUS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9685:LOC102901994
gene id: 9685:LOC102901994
uniprot id: A0A5F5XT71
names: Similarity
messages: Belongs to the MS4A family.

9685:LOC101091558
gene id: 9685:LOC101091558
uniprot id: M3WND9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9685:VSNL1
gene id: 9685:VSNL1
uniprot id: M3WUY2
names: Function
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

9685:CLSPN
gene id: 9685:CLSPN
uniprot id: A0A2I2U4M4
names: Subcellular Location Annotation
messages: Nucleus

9685:BCL2A1
gene id: 9685:BCL2A1
uniprot id: M3WHW2
names: Similarity
messages: Belongs to the Bcl-2 family.

9685:CASP10
gene id: 9685:CASP10
uniprot id: M3W2Q5
names: Similarity
messages: Belongs to the peptidase C14A family.

9685:MAP2K6
gene id: 9685:MAP2K6
uniprot id: M3WN25
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:PDE4D
gene id: 9685:PDE4D
uniprot id: A0A2I2UF71
uniprot id: A0A5F5XH54
uniprot id: A0A5F5XY00
uniprot id: M3X0T1
uniprot id: M3XEU1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9685:TAT
gene id: 9685:TAT
uniprot id: M3W228
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9685:KEF43 p04
gene id: 9685:KEF43_p04
uniprot id: P48916
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9685:HOXC8
gene id: 9685:HOXC8
uniprot id: M3W2T7
names: Subcellular Location Annotation
messages: Nucleus

9685:CCL21
gene id: 9685:CCL21
uniprot id: M3VZU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:NDUFS8
gene id: 9685:NDUFS8
uniprot id: M3VZI9
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

9685:STX7
gene id: 9685:STX7
uniprot id: A0A2I2UJ09
uniprot id: A0A337S3R7
names: Similarity
messages: Belongs to the syntaxin family.

9685:RNFT2
gene id: 9685:RNFT2
uniprot id: M3VVT1
names: Subcellular Location Annotation
messages: Membrane

9685:ZNF687
gene id: 9685:ZNF687
uniprot id: M3W4A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9685:TMEM39A
gene id: 9685:TMEM39A
uniprot id: M3XFQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9685:GALNTL6
gene id: 9685:GALNTL6
uniprot id: M3W8Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9685:CACNA1D
gene id: 9685:CACNA1D
uniprot id: A0A2I2U2W4
uniprot id: A0A2I2V0N7
uniprot id: A0A337S157
uniprot id: A0A5F5Y578
uniprot id: M3W4E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9685:GCNT3
gene id: 9685:GCNT3
uniprot id: M3WHV2
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9685:SNAP47
gene id: 9685:SNAP47
uniprot id: M3WMY2
names: Similarity
messages: Belongs to the SVAP1 family.

9685:MKNK1
gene id: 9685:MKNK1
uniprot id: A0A337SSQ7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:NUDT21
gene id: 9685:NUDT21
uniprot id: M3WA00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

9685:CDK5R1
gene id: 9685:CDK5R1
uniprot id: M3W9T0
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

9685:TERF1
gene id: 9685:TERF1
uniprot id: A0A2I2UNQ6
uniprot id: A0A337SU83
uniprot id: M3XBD0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

9685:DOCK2
gene id: 9685:DOCK2
uniprot id: M3VVI0
names: Similarity
messages: Belongs to the DOCK family.

9685:MFF
gene id: 9685:MFF
uniprot id: A0A337S3V7
uniprot id: A0A5F5XSR9
uniprot id: A0A5F5XU69
uniprot id: M3WCN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
messages: synaptic vesicle

9685:STARD6
gene id: 9685:STARD6
uniprot id: M3X4R8
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9685:RTN2
gene id: 9685:RTN2
uniprot id: A0A2I2UI00
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9685:VPS52
gene id: 9685:VPS52
uniprot id: M3W1E1
names: Similarity
messages: Belongs to the VPS52 family.

9685:LOC101085313
gene id: 9685:LOC101085313
uniprot id: M3X1Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CCNB2
gene id: 9685:CCNB2
uniprot id: M3WBE0
names: Similarity
messages: Belongs to the cyclin family.

9685:PPIH
gene id: 9685:PPIH
uniprot id: G3XEW8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9685:SUMF2
gene id: 9685:SUMF2
uniprot id: M3VZI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9685:C1QA
gene id: 9685:C1QA
uniprot id: M3WS63
names: Function
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

9685:LOC105260530
gene id: 9685:LOC105260530
uniprot id: A0A2I2UQQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:LOC101093701
gene id: 9685:LOC101093701
uniprot id: A0A5F5XN98
uniprot id: M3WFW3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9685:LOC101091336
gene id: 9685:LOC101091336
uniprot id: M3WKD2
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9685:RPS6KB2
gene id: 9685:RPS6KB2
uniprot id: M3W099
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9685:STARD13
gene id: 9685:STARD13
uniprot id: A0A5F5XWD6
names: Subcellular Location Annotation
messages: Cytoplasm

9685:ATG12
gene id: 9685:ATG12
uniprot id: M3W807
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9685:DPH6
gene id: 9685:DPH6
uniprot id: A0A2I2UIY9
uniprot id: M3WC98
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9685:CRELD2
gene id: 9685:CRELD2
uniprot id: M3WQ40
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:HIGD2A
gene id: 9685:HIGD2A
uniprot id: M3W7A4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9685:NEIL3
gene id: 9685:NEIL3
uniprot id: M3W367
names: Similarity
messages: Belongs to the FPG family.

9685:THUMPD2
gene id: 9685:THUMPD2
uniprot id: M3W6J0
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9685:TNFRSF4
gene id: 9685:TNFRSF4
uniprot id: Q75SV8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LOC101084707
gene id: 9685:LOC101084707
uniprot id: M3X726
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:ZDHHC17
gene id: 9685:ZDHHC17
uniprot id: M3WZ05
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9685:POLD2
gene id: 9685:POLD2
uniprot id: M3WKK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9685:ANTKMT
gene id: 9685:ANTKMT
uniprot id: A0A2I2V2F8
uniprot id: A0A337S4G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9685:INPP5A
gene id: 9685:INPP5A
uniprot id: M3WE58
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

9685:ITGAE
gene id: 9685:ITGAE
uniprot id: Q8MKF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9685:ZC3HAV1
gene id: 9685:ZC3HAV1
uniprot id: M3X2R1
names: Similarity
messages: Belongs to the ARTD/PARP family.

9685:SSR4
gene id: 9685:SSR4
uniprot id: M3W1G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9685:LOC101086178
gene id: 9685:LOC101086178
uniprot id: M3WSP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:NUP107
gene id: 9685:NUP107
uniprot id: M3WHP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

9685:RPL23A
gene id: 9685:RPL23A
uniprot id: M3W1E8
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9685:SMARCD1
gene id: 9685:SMARCD1
uniprot id: A0A2I2UTR2
names: Similarity
messages: Belongs to the SMARCD family.

9685:MET
gene id: 9685:MET
uniprot id: A0M8S8
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Membrane
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9685:TMEM106B
gene id: 9685:TMEM106B
uniprot id: M3W5X2
names: Similarity
messages: Belongs to the TMEM106 family.

9685:ATP11C
gene id: 9685:ATP11C
uniprot id: A0A2I2U6C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9685:TECRL
gene id: 9685:TECRL
uniprot id: M3XC35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9685:RAD18
gene id: 9685:RAD18
uniprot id: A0A5F5XU25
uniprot id: M3XD01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9685:POFUT1
gene id: 9685:POFUT1
uniprot id: M3WRS8
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

9685:LOC101094135
gene id: 9685:LOC101094135
uniprot id: A0A2I2V3S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9685:UCMA
gene id: 9685:UCMA
uniprot id: A0A5F5XCV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

9685:UQCC3
gene id: 9685:UQCC3
uniprot id: M3X8X0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9685:ASF1A
gene id: 9685:ASF1A
uniprot id: A0A5F5Y6V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9685:RPL22
gene id: 9685:RPL22
uniprot id: A0A2I2UNG3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9685:AMT
gene id: 9685:AMT
uniprot id: A0A337SVD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9685:FUNDC2
gene id: 9685:FUNDC2
uniprot id: M3X325
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9685:LOC102899713
gene id: 9685:LOC102899713
uniprot id: A0A5F5XEP4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:CENPH
gene id: 9685:CENPH
uniprot id: A0A2I2V0F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9685:HAPLN3
gene id: 9685:HAPLN3
uniprot id: A0A2I2UXX9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9685:MUTYH
gene id: 9685:MUTYH
uniprot id: A0A5F5Y3T9
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

9685:LOC101092762
gene id: 9685:LOC101092762
uniprot id: M3WSM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:RPL3L
gene id: 9685:RPL3L
uniprot id: M3WFN6
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9685:GNRH1
gene id: 9685:GNRH1
uniprot id: M3X2M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

9685:ORMDL1
gene id: 9685:ORMDL1
uniprot id: A0A337S5E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9685:EIF3F
gene id: 9685:EIF3F
uniprot id: A0A2I2US80
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9685:GABRA6
gene id: 9685:GABRA6
uniprot id: A0A337SQ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:GABRG1
gene id: 9685:GABRG1
uniprot id: A0A2I2UYM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:APEX2
gene id: 9685:APEX2
uniprot id: M3X3R1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9685:URGCP
gene id: 9685:URGCP
uniprot id: A0A5F5Y4E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9685:LOC101081251
gene id: 9685:LOC101081251
uniprot id: M3X2X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:UCP1
gene id: 9685:UCP1
uniprot id: M3WAF9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

9685:KCNAB1
gene id: 9685:KCNAB1
uniprot id: A0A337SL12
uniprot id: A0A337SW96
uniprot id: A0A337SWA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9685:GPATCH11
gene id: 9685:GPATCH11
uniprot id: A0A5F5XYY2
names: Similarity
messages: Belongs to the GPATCH11 family.

9685:HSCB
gene id: 9685:HSCB
uniprot id: A0A2I2U3M8
uniprot id: A0A337SF44
names: Similarity
messages: Belongs to the HscB family.

9685:CACNG2
gene id: 9685:CACNG2
uniprot id: M3WZA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

9685:DNAJC18
gene id: 9685:DNAJC18
uniprot id: M3VX61
names: Subcellular Location Annotation
messages: Membrane

9685:SF3B5
gene id: 9685:SF3B5
uniprot id: M3VVN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9685:TTYH2
gene id: 9685:TTYH2
uniprot id: M3WE23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9685:GABRB1
gene id: 9685:GABRB1
uniprot id: M3W754
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:HP
gene id: 9685:HP
uniprot id: E3UTY9
names: Caution
names: Function
names: Similarity
messages: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9685:LOC101084129
gene id: 9685:LOC101084129
uniprot id: M3WE33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9685:GPR161
gene id: 9685:GPR161
uniprot id: A0A2I2U9P3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:RSBN1L
gene id: 9685:RSBN1L
uniprot id: M3W1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9685:CYP2F1
gene id: 9685:CYP2F1
uniprot id: M3WWL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane
messages: Microsome membrane

9685:TUBB4B
gene id: 9685:TUBB4B
uniprot id: M3W0Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9685:GHRHR
gene id: 9685:GHRHR
uniprot id: M3VYQ3
names: Subcellular Location Annotation
messages: Membrane

9685:HNRNPDL
gene id: 9685:HNRNPDL
uniprot id: M3VUT2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9685:PHB1
gene id: 9685:PHB1
uniprot id: A8WA76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9685:NAMPT
gene id: 9685:NAMPT
uniprot id: M3WY46
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

9685:BRCA2
gene id: 9685:BRCA2
uniprot id: Q864S8
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity).
messages: Monomer and dimer. Interacts with RAD51; regulates RAD51 recruitment and function at sites of DNA repair. Interacts with SEM1, WDR16, USP11, DMC1, ROCK2 and NPM1. Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Component of the homologous recombination repair (HR) complex composed of ERCC5/XPG, BRCA2, PALB2, DSS1 and RAD51 (By similarity). Within the complex, interacts with ERCC5/XPG and PALB2 (By similarity). Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein. Interacts with POLH; the interaction is direct. Interacts with the TREX-2 complex subunits PCID2 and SEM1 (By similarity). Interacts with HSF2BP and BRME1; the interaction with HSF2BP is direct and allows the formation of a ternary complex. The complex BRME1:HSF2BP:BRCA2 interacts with SPATA22, MEIOB and RAD51 (By similarity).
messages: Nucleus
messages: Phosphorylated by ATM upon irradiation-induced DNA damage. Phosphorylation by CHEK1 and CHEK2 regulates interaction with RAD51. Phosphorylation at Ser-3236 by CDK1 and CDK2 is low in S phase when recombination is active, but increases as cells progress towards mitosis; this phosphorylation prevents homologous recombination-dependent repair during S phase and G2 by inhibiting RAD51 binding.
messages: Ubiquitinated in the absence of DNA damage; this does not lead to proteasomal degradation. In contrast, ubiquitination in response to DNA damage leads to proteasomal degradation.
messages: centrosome

9685:TBX15
gene id: 9685:TBX15
uniprot id: A0A2I2UY24
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9685:SAXO1
gene id: 9685:SAXO1
uniprot id: M3W2Y6
names: Similarity
messages: Belongs to the FAM154 family.

9685:CCL20
gene id: 9685:CCL20
uniprot id: M3W0B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9685:GDF5
gene id: 9685:GDF5
uniprot id: A0A2I2URW3
names: Similarity
messages: Belongs to the TGF-beta family.

9685:ASIP
gene id: 9685:ASIP
uniprot id: A0A2I2UIB8
uniprot id: Q865F0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
messages: Secreted
messages: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

9685:TRAPPC6A
gene id: 9685:TRAPPC6A
uniprot id: M3WRW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9685:SF3A3
gene id: 9685:SF3A3
uniprot id: M3XB41
names: Similarity
messages: Belongs to the SF3A3 family.

9685:IFNW11
gene id: 9685:IFNW11
uniprot id: Q0GYU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9685:GABRA5
gene id: 9685:GABRA5
uniprot id: M3WG25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9685:TIMP3
gene id: 9685:TIMP3
uniprot id: A0A2I2UAQ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts with EFEMP1.
messages: extracellular matrix

9685:LGI3
gene id: 9685:LGI3
uniprot id: M3W3T4
names: Subcellular Location Annotation
messages: Secreted

9685:TM4SF1
gene id: 9685:TM4SF1
uniprot id: M3WJF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9685:PDCL3
gene id: 9685:PDCL3
uniprot id: M3X7S3
names: Similarity
messages: Belongs to the phosducin family.

9685:JMY
gene id: 9685:JMY
uniprot id: M3WTG5
names: Subcellular Location Annotation
messages: Membrane

9685:ELMO3
gene id: 9685:ELMO3
uniprot id: A0A337SDU3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9685:PTK2B
gene id: 9685:PTK2B
uniprot id: A0A2I2ULP1
uniprot id: A0A2I2UXW4
uniprot id: A0A337ST84
uniprot id: M3WXA1
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9685:NDST3
gene id: 9685:NDST3
uniprot id: M3W3G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9685:NPM3
gene id: 9685:NPM3
uniprot id: M3W794
names: Similarity
messages: Belongs to the nucleoplasmin family.

9685:IL4
gene id: 9685:IL4
uniprot id: A0A337RWU7
uniprot id: P55030
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
messages: Secreted

9685:FOXP1
gene id: 9685:FOXP1
uniprot id: M3WVD8
names: Subcellular Location Annotation
messages: Nucleus

9685:AQP3
gene id: 9685:AQP3
uniprot id: A0A2I2UBV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9685:SMPX
gene id: 9685:SMPX
uniprot id: A0A337RWK0
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

9685:ARAF
gene id: 9685:ARAF
uniprot id: M3X071
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9685:CCNI
gene id: 9685:CCNI
uniprot id: M3W0P9
names: Similarity
messages: Belongs to the cyclin family.

9685:DEF8
gene id: 9685:DEF8
uniprot id: A0A337SHB6
names: Similarity
messages: Belongs to the DEF8 family.

9685:REM2
gene id: 9685:REM2
uniprot id: M3W684
names: Subcellular Location Annotation
messages: Cell membrane

9685:CUTC
gene id: 9685:CUTC
uniprot id: M3X7S8
names: Similarity
messages: Belongs to the CutC family.

9685:NOP56
gene id: 9685:NOP56
uniprot id: M3WKR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9685:HEXA
gene id: 9685:HEXA
uniprot id: G4XSV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9685:KCNA1
gene id: 9685:KCNA1
uniprot id: M3W515
names: Subcellular Location Annotation
messages: Membrane

9685:IFIH1
gene id: 9685:IFIH1
uniprot id: A0A337SUY7
uniprot id: M3W7H1
uniprot id: M3WY86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9685:SLC26A4
gene id: 9685:SLC26A4
uniprot id: A0A337SMB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

9685:CLCN5
gene id: 9685:CLCN5
uniprot id: M3W9W9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9685:PRPF18
gene id: 9685:PRPF18
uniprot id: A0A2I2UKC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9685:UGP2
gene id: 9685:UGP2
uniprot id: A0A2I2U7R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9685:SDC2
gene id: 9685:SDC2
uniprot id: M3WXE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9685:SSBP1
gene id: 9685:SSBP1
uniprot id: A0A2I2V3I8
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9685:TAF5
gene id: 9685:TAF5
uniprot id: M3VYE8
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9685:TGFB3
gene id: 9685:TGFB3
uniprot id: M3WKA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9685:SLC6A14
gene id: 9685:SLC6A14
uniprot id: M3XF00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9685:ALKBH5
gene id: 9685:ALKBH5
uniprot id: A0A2I2UW44
names: Subcellular Location Annotation
names: Subunit
messages: Monomer.
messages: Nucleus speckle

9685:MYO1B
gene id: 9685:MYO1B
uniprot id: A0A2I2UEY9
uniprot id: A0A2I2UNH6
uniprot id: M3WJQ2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9685:SENP6
gene id: 9685:SENP6
uniprot id: A0A2I2UFB5
names: Similarity
messages: Belongs to the peptidase C48 family.

9685:LOC101089671
gene id: 9685:LOC101089671
uniprot id: M3XDJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:COX4I2
gene id: 9685:COX4I2
uniprot id: M3WL40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9685:CD2H10orf53
gene id: 9685:CD2H10orf53
uniprot id: M3X8J2
names: Similarity
messages: Belongs to the UPF0728 family.

9685:RAE1
gene id: 9685:RAE1
uniprot id: A0A2I2UGZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat rae1 family.
messages: spindle pole

9685:USP7
gene id: 9685:USP7
uniprot id: A0A2I2UPP8
names: Similarity
messages: Belongs to the peptidase C19 family.

9685:NTF3
gene id: 9685:NTF3
uniprot id: Q9TST2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9685:LYRM2
gene id: 9685:LYRM2
uniprot id: M3WAE7
names: Similarity
messages: Belongs to the complex I LYR family.

9685:DOCK1
gene id: 9685:DOCK1
uniprot id: M3W9G8
names: Similarity
messages: Belongs to the DOCK family.

9685:IL17RB
gene id: 9685:IL17RB
uniprot id: M3W4E6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9685:C6
gene id: 9685:C6
uniprot id: M3WLH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:ECH1
gene id: 9685:ECH1
uniprot id: M3VZV7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9685:RBX1
gene id: 9685:RBX1
uniprot id: M3X867
names: Similarity
messages: Belongs to the RING-box family.

9685:SLC30A2
gene id: 9685:SLC30A2
uniprot id: A0A337SHT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9685:LOC101101309
gene id: 9685:LOC101101309
uniprot id: A0A337SN81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CAMK1
gene id: 9685:CAMK1
uniprot id: M3WK93
names: Similarity
messages: Belongs to the protein kinase superfamily.

9685:OSTC
gene id: 9685:OSTC
uniprot id: A0A2I2UAV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9685:LOC101100505
gene id: 9685:LOC101100505
uniprot id: M3XFG8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:CRYGA
gene id: 9685:CRYGA
uniprot id: M3W1B5
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9685:CACNA1S
gene id: 9685:CACNA1S
uniprot id: A0A2I2UAM3
uniprot id: Q2QCM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9685:TFAP2D
gene id: 9685:TFAP2D
uniprot id: M3W0C3
names: Similarity
messages: Belongs to the AP-2 family.

9685:LOC101080967
gene id: 9685:LOC101080967
uniprot id: M3W6J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9685:GJA10
gene id: 9685:GJA10
uniprot id: M3WAF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9685:ASZ1
gene id: 9685:ASZ1
uniprot id: A0M8T3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

9685:DPH5
gene id: 9685:DPH5
uniprot id: A0A2I2UH15
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9685:TARBP2
gene id: 9685:TARBP2
uniprot id: M3W8A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9685:IP6K2
gene id: 9685:IP6K2
uniprot id: M3WUD3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9685:GPAT3
gene id: 9685:GPAT3
uniprot id: A0A337SQ69
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9685:LOC101080826
gene id: 9685:LOC101080826
uniprot id: M3WJA1
names: Similarity
messages: Belongs to the peptidase A1 family.

9685:MOCS3
gene id: 9685:MOCS3
uniprot id: M3X4P1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

9685:ZNF174
gene id: 9685:ZNF174
uniprot id: A0A337RU12
uniprot id: M3WGM4
names: Subcellular Location Annotation
messages: Nucleus

9685:TRMO
gene id: 9685:TRMO
uniprot id: M3WEA0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9685:COG8
gene id: 9685:COG8
uniprot id: M3WJ31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

9685:CCDC85A
gene id: 9685:CCDC85A
uniprot id: A0A2I2U6A6
uniprot id: A0A2I2USC7
uniprot id: A0A2I2UT97
uniprot id: M3VVE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9685:PCMTD1
gene id: 9685:PCMTD1
uniprot id: M3VW62
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9685:SLC35A3
gene id: 9685:SLC35A3
uniprot id: M3X4D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9685:AKT1
gene id: 9685:AKT1
uniprot id: A0A143RHU3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9685:LOC102901968
gene id: 9685:LOC102901968
uniprot id: M3WY24
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9685:SGMS2
gene id: 9685:SGMS2
uniprot id: M3WGN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9685:KRTAP3-1
gene id: 9685:KRTAP3-1
uniprot id: M3WIM6
names: Similarity
messages: Belongs to the KRTAP type 3 family.

9685:CCR1
gene id: 9685:CCR1
uniprot id: B6DXF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9685:GREM2
gene id: 9685:GREM2
uniprot id: M3W3X3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9685:PTH2
gene id: 9685:PTH2
uniprot id: M3VWT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

9685:LOC101080615
gene id: 9685:LOC101080615
uniprot id: M3XCS3
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9685:NKAPL
gene id: 9685:NKAPL
uniprot id: M3WUU0
names: Similarity
messages: Belongs to the NKAP family.

9685:NLGN4X
gene id: 9685:NLGN4X
uniprot id: A0A2I2V3E5
uniprot id: M3VUM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9685:LDHA
gene id: 9685:LDHA
uniprot id: A0A337S8L1
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9685:LOC105260541
gene id: 9685:LOC105260541
uniprot id: M3XAW8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:SEPTIN6
gene id: 9685:SEPTIN6
uniprot id: A0A2I2U142
uniprot id: A0A2I2UPK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9685:FAM83G
gene id: 9685:FAM83G
uniprot id: M3WMK7
names: Similarity
messages: Belongs to the FAM83 family.

9685:LOC101094019
gene id: 9685:LOC101094019
uniprot id: A0A337SD17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9685:PTPN14
gene id: 9685:PTPN14
uniprot id: M3WUZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9685:LYRM1
gene id: 9685:LYRM1
uniprot id: A0A2I2UNX2
names: Similarity
messages: Belongs to the complex I LYR family.

9685:UCHL3
gene id: 9685:UCHL3
uniprot id: A0A337S3N7
names: Similarity
messages: Belongs to the peptidase C12 family.

9685:TNFAIP3
gene id: 9685:TNFAIP3
uniprot id: A0A2I2UZV8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9685:USP39
gene id: 9685:USP39
uniprot id: A0A337S3L1
names: Subcellular Location Annotation
messages: Nucleus

9685:CXCR5
gene id: 9685:CXCR5
uniprot id: M3XAS4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9685:NDUFS3
gene id: 9685:NDUFS3
uniprot id: A0A2I2U833
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.