9615:SLC43A1
gene id: 9615:SLC43A1
uniprot id: A0A8C0ML92
uniprot id: E2QXB4
names: Subcellular Location Annotation
messages: Membrane

9615:POLRMT
gene id: 9615:POLRMT
uniprot id: A0A8C0SAC0
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9615:ARPC5
gene id: 9615:ARPC5
uniprot id: A0A8C0LYM6
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9615:API5
gene id: 9615:API5
uniprot id: A0A8C0MAM9
names: Similarity
messages: Belongs to the API5 family.

9615:TAF2
gene id: 9615:TAF2
uniprot id: A0A8C0MGM6
uniprot id: A0A8C0S8E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

9615:PAFAH1B1
gene id: 9615:PAFAH1B1
uniprot id: A0A8C0Q2T5
uniprot id: A0A8I3NIJ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: centrosome
messages: cytoskeleton
messages: spindle

9615:FGF16
gene id: 9615:FGF16
uniprot id: A0A8C0SP20
uniprot id: J9P8K0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:ELL3
gene id: 9615:ELL3
uniprot id: A0A8C0NM92
uniprot id: A0A8I3Q8S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9615:IFT122
gene id: 9615:IFT122
uniprot id: A0A8C0P3B3
uniprot id: A0A8C0TDI1
uniprot id: A0A8C0Z3T7
uniprot id: A0A8P0P4I7
uniprot id: A0A8P0SAH2
uniprot id: A0A8P0T6V3
names: Subcellular Location Annotation
messages: cilium

9615:LOC611915
gene id: 9615:LOC611915
uniprot id: A0A8I3N5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:IRAK1BP1
gene id: 9615:IRAK1BP1
uniprot id: A0A8C0MNJ1
uniprot id: A0A8C0MNQ1
uniprot id: A0A8I3MZB8
uniprot id: A0A8I3N9Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9615:LOC100688040
gene id: 9615:LOC100688040
uniprot id: A0A8C0Z6L1
uniprot id: A0A8I3P2K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

9615:MED9
gene id: 9615:MED9
uniprot id: A0A8C0PYQ8
uniprot id: A0A8I3PGL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:STK10
gene id: 9615:STK10
uniprot id: A0A8C0PY59
uniprot id: A0A8P0NI79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane

9615:SLC16A12
gene id: 9615:SLC16A12
uniprot id: A0A8C0NVK2
uniprot id: A0A8I3PW22
uniprot id: A0A8I3Q558
names: Subcellular Location Annotation
messages: Membrane

9615:GTPBP8
gene id: 9615:GTPBP8
uniprot id: A0A8C0PKW5
uniprot id: A0A8I3Q118
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9615:PIGN
gene id: 9615:PIGN
uniprot id: A0A8P0N3B3
uniprot id: A0A8P0P796
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

9615:SAMHD1
gene id: 9615:SAMHD1
uniprot id: A0A8C0SIE9
uniprot id: A0A8I3PZF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9615:PEX2
gene id: 9615:PEX2
uniprot id: A0A8I3QJQ7
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9615:CCND3
gene id: 9615:CCND3
uniprot id: A0A8C0MF30
uniprot id: A0A8I3NNP3
uniprot id: A0A8I3NU52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9615:LOC102157323
gene id: 9615:LOC102157323
uniprot id: A0A8C0RN37
uniprot id: A0A8I3NWZ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9615:NAP1L5
gene id: 9615:NAP1L5
uniprot id: A0A8C0SSR9
uniprot id: A0A8I3P5G7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:TRMT2A
gene id: 9615:TRMT2A
uniprot id: A0A8C0RNG0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:HPD
gene id: 9615:HPD
uniprot id: A0A8C0Z0E2
uniprot id: A0A8I3PEX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9615:TMTC3
gene id: 9615:TMTC3
uniprot id: A0A8C0SQG9
uniprot id: A0A8I3S0E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9615:CUL4A
gene id: 9615:CUL4A
uniprot id: A0A8C0RRK5
names: Similarity
messages: Belongs to the cullin family.

9615:DAPK3
gene id: 9615:DAPK3
uniprot id: A0A8C0MCW0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:SLC41A1
gene id: 9615:SLC41A1
uniprot id: A0A8C0MYU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9615:NPY1R
gene id: 9615:NPY1R
uniprot id: O02813
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for neuropeptide Y and peptide YY.

9615:HSD17B10
gene id: 9615:HSD17B10
uniprot id: A0A8C0MXS2
uniprot id: A0A8I3Q7T6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:AICDA
gene id: 9615:AICDA
uniprot id: Q75W64
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm
messages: Expressed in thymus, lung, spleen, kidney, small intestine, lymph node and tonsil.
messages: Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with SUPT6H, TRIM28 and NCL. Directly interacts with MCM3AP; this interaction may favor AICDA recruitment to immunoglobulin variable region genes, hence promoting somatic hypermutations (By similarity).
messages: Nucleus
messages: Probably monoubiquitinated on several residues by RNF126.
messages: Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity (By similarity).
messages: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

9615:ENTPD1
gene id: 9615:ENTPD1
uniprot id: A0A8C0PFT7
uniprot id: A0A8C0PG00
uniprot id: A0A8C0TQB2
uniprot id: A0A8I3PR21
uniprot id: A0A8I3Q7F5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:FAP
gene id: 9615:FAP
uniprot id: A0A8C0NKP1
uniprot id: A0A8I3Q938
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9615:CIRBP
gene id: 9615:CIRBP
uniprot id: A0A8C0RMV5
uniprot id: A0A8I3NK39
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

9615:LOC100685649
gene id: 9615:LOC100685649
uniprot id: A0A8C0NMA4
uniprot id: A0A8I3PK68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9615:TNKS
gene id: 9615:TNKS
uniprot id: A0A8C0RY64
uniprot id: A0A8I3RZQ8
names: Function
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9615:LAMP5
gene id: 9615:LAMP5
uniprot id: A0A8P0SB63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9615:CLPTM1
gene id: 9615:CLPTM1
uniprot id: A0A8C0RAV7
uniprot id: A0A8I3MSH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9615:KCNJ6
gene id: 9615:KCNJ6
uniprot id: A0A8C0TE53
uniprot id: A0A8I3PXZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9615:ITGA2
gene id: 9615:ITGA2
uniprot id: A0A8C0S0G4
uniprot id: A0A8I3MC22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:GIMAP7
gene id: 9615:GIMAP7
uniprot id: A0A8I3NNE6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9615:TTC4
gene id: 9615:TTC4
uniprot id: A0A8C0PPD0
uniprot id: A0A8I3NU85
names: Similarity
messages: Belongs to the TTC4 family.

9615:LOC100688077
gene id: 9615:LOC100688077
uniprot id: A0A8C0QAA5
uniprot id: A0A8I3NLR1
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9615:HHEX
gene id: 9615:HHEX
uniprot id: A0A8C0Z3B6
uniprot id: A0A8I3NTG1
names: Subcellular Location Annotation
messages: Nucleus

9615:ZDHHC4
gene id: 9615:ZDHHC4
uniprot id: A0A8C0YYT7
uniprot id: A0A8I3NP64
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:DGKA
gene id: 9615:DGKA
uniprot id: A0A8C0Q5Y6
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9615:ARSF
gene id: 9615:ARSF
uniprot id: A0A8P0ND70
names: Similarity
messages: Belongs to the sulfatase family.

9615:FAM83G
gene id: 9615:FAM83G
uniprot id: A0A8I3P584
names: Similarity
messages: Belongs to the FAM83 family.

9615:GAD1
gene id: 9615:GAD1
uniprot id: A0PA85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
messages: Homodimer.

9615:CRKL
gene id: 9615:CRKL
uniprot id: A0A8C0TFX5
uniprot id: A0A8I3PN08
names: Similarity
messages: Belongs to the CRK family.

9615:ACTB
gene id: 9615:ACTB
uniprot id: O18840
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
messages: Belongs to the actin family.
messages: ISGylated.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-73 by SETD3 (By similarity). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).
messages: Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM (By similarity). Interacts with TBC1D21. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes. Interacts with FAM107A (By similarity).
messages: cytoskeleton

9615:HPGD
gene id: 9615:HPGD
uniprot id: A0A8C0NXZ1
uniprot id: E2QX67
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:EFNA3
gene id: 9615:EFNA3
uniprot id: A0A8C0PDI3
uniprot id: A0A8I3NEL5
uniprot id: A0A8I3NG87
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:BANP
gene id: 9615:BANP
uniprot id: A0A8C0NPT8
uniprot id: A0A8C0NRV1
uniprot id: A0A8I3ML24
uniprot id: A0A8I3N6J3
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9615:PSMG2
gene id: 9615:PSMG2
uniprot id: A0A8I3RSK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9615:SLC15A2
gene id: 9615:SLC15A2
uniprot id: A0A8I3S5G4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9615:TMEM147
gene id: 9615:TMEM147
uniprot id: A0A8C0RUW0
uniprot id: A0A8I3MKU8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:CFHR5
gene id: 9615:CFHR5
uniprot id: A0A8C0SK64
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CD79B
gene id: 9615:CD79B
uniprot id: A0A8P0SHE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:MASP1
gene id: 9615:MASP1
uniprot id: A0A8C0NS70
uniprot id: A0A8C0NV46
uniprot id: A0A8C0P4N4
uniprot id: A0A8I3PF98
uniprot id: A0A8I3PJ55
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:GSS
gene id: 9615:GSS
uniprot id: A0A8C0QD92
uniprot id: A0A8I3NS50
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9615:WNT8A
gene id: 9615:WNT8A
uniprot id: A0A8I3P6J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:OVCA2
gene id: 9615:OVCA2
uniprot id: A0A8I3NUC8
names: Similarity
messages: Belongs to the LovG family.

9615:OR52H9
gene id: 9615:OR52H9
uniprot id: A0A8C0T0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:INO80
gene id: 9615:INO80
uniprot id: A0A8C0TVH1
uniprot id: A0A8I3SC62
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9615:CWF19L1
gene id: 9615:CWF19L1
uniprot id: A0A8C0NXL7
uniprot id: A0A8C0T5W9
uniprot id: A0A8I3NP38
names: Similarity
messages: Belongs to the CWF19 family.

9615:OR13F1B
gene id: 9615:OR13F1B
uniprot id: A0A8C0P0J7
uniprot id: A0A8I3N2K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:UQCC3
gene id: 9615:UQCC3
uniprot id: A0A8C0MI20
uniprot id: A0A8I3N4J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9615:SORBS2
gene id: 9615:SORBS2
uniprot id: A0A8C0NQB1
uniprot id: A0A8I3S4E4
names: Subcellular Location Annotation
messages: focal adhesion

9615:MYH4
gene id: 9615:MYH4
uniprot id: Q076A5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-4 (MYO4).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9615:MYO1E
gene id: 9615:MYO1E
uniprot id: A0A8C0N2D5
uniprot id: A0A8I3NQ19
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9615:BTAF1
gene id: 9615:BTAF1
uniprot id: A0A8C0NHA6
uniprot id: A0A8I3Q2K3
names: Subcellular Location Annotation
messages: Nucleus

9615:KIF2A
gene id: 9615:KIF2A
uniprot id: A0A8C0Q031
uniprot id: A0A8C0RW90
uniprot id: A0A8I3MZX0
uniprot id: A0A8I3NL14
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:CD47
gene id: 9615:CD47
uniprot id: A0A8C0P2Q2
uniprot id: A0A8I3PHN5
uniprot id: A1Z2X6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:MTMR7
gene id: 9615:MTMR7
uniprot id: A0A8C0RZK8
uniprot id: A0A8P0N9B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9615:POLR1E
gene id: 9615:POLR1E
uniprot id: A0A8C0MLU4
uniprot id: A0A8P0S866
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9615:KRT13
gene id: 9615:KRT13
uniprot id: A0A8C0S9A5
names: Similarity
messages: Belongs to the intermediate filament family.

9615:FTSJ1
gene id: 9615:FTSJ1
uniprot id: A0A8C0MMA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

9615:MEF2C
gene id: 9615:MEF2C
uniprot id: A0A8C0MTG5
uniprot id: A0A8C0RW75
uniprot id: A0A8I3NTX7
uniprot id: A0A8I3P305
uniprot id: A0A8I3P461
uniprot id: A0A8I3S009
names: Subcellular Location Annotation
messages: Nucleus

9615:HOXC6
gene id: 9615:HOXC6
uniprot id: A0A8C0T8M4
uniprot id: A0A8I3NVN6
names: Subcellular Location Annotation
messages: Nucleus

9615:STAR
gene id: 9615:STAR
uniprot id: A0A8C0NF55
uniprot id: A5A394
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9615:MMACHC
gene id: 9615:MMACHC
uniprot id: A0A8C0Z170
names: Similarity
messages: Belongs to the MMACHC family.

9615:KYAT3
gene id: 9615:KYAT3
uniprot id: A0A8I3P794
names: Subunit
messages: Homodimer.

9615:SLC7A6
gene id: 9615:SLC7A6
uniprot id: A0A8I3RYK4
names: Subcellular Location Annotation
messages: Membrane

9615:NUPR2
gene id: 9615:NUPR2
uniprot id: A0A8C0LXG5
uniprot id: A0A8I3RZX4
names: Similarity
messages: Belongs to the NUPR family.

9615:ADGRL3
gene id: 9615:ADGRL3
uniprot id: A0A8I3NTN3
uniprot id: A0A8I3NW47
names: Subcellular Location Annotation
messages: Membrane

9615:RRP7
gene id: 9615:RRP7
uniprot id: A0A8C0YYC0
uniprot id: A0A8I3S121
names: Similarity
messages: Belongs to the RRP7 family.

9615:FNIP1
gene id: 9615:FNIP1
uniprot id: A0A8C0SIT7
uniprot id: A0A8C0SK02
uniprot id: A0A8I3NKW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9615:MYOZ1
gene id: 9615:MYOZ1
uniprot id: A0A8C0PX17
uniprot id: Q1AG03
names: Similarity
messages: Belongs to the myozenin family.

9615:GSTA4
gene id: 9615:GSTA4
uniprot id: A0A8C0NR48
uniprot id: A0A8I3NBL2
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9615:RETREG3
gene id: 9615:RETREG3
uniprot id: A0A8C0QJ10
uniprot id: A0A8I3MY43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9615:ENPEP
gene id: 9615:ENPEP
uniprot id: A0A8I3P176
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Membrane
messages: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

9615:SLC22A5
gene id: 9615:SLC22A5
uniprot id: A0A8C0N0F2
uniprot id: A0A8I3NDB5
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9615:LMAN2
gene id: 9615:LMAN2
uniprot id: P49256
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 2 calcium ions per subunit.
messages: Expressed in kidney, liver, intestine, lung, spleen and heart. Low expression in brain.
messages: Golgi apparatus membrane
messages: Monomer.
messages: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans.

9615:PTGER1
gene id: 9615:PTGER1
uniprot id: A0A8P0NHQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:CSRNP1
gene id: 9615:CSRNP1
uniprot id: A0A8I3QC00
uniprot id: A0A8I3QSX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9615:PPP2R5C
gene id: 9615:PPP2R5C
uniprot id: A0A8I3NBL1
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9615:ANO4
gene id: 9615:ANO4
uniprot id: A0A8C0NF66
uniprot id: A0A8P0SCD8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:H3C1
gene id: 9615:H3C1
uniprot id: A0A8C0TQX3
uniprot id: J9PB22
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:OCIAD1
gene id: 9615:OCIAD1
uniprot id: A0A8C0SFC6
uniprot id: A0A8I3RXW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9615:LYG1
gene id: 9615:LYG1
uniprot id: A0A8C0NT03
uniprot id: A0A8I3P497
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9615:BRPF1
gene id: 9615:BRPF1
uniprot id: A0A8C0TTT5
uniprot id: A0A8I3NMP5
names: Subcellular Location Annotation
messages: Nucleus

9615:FAT2
gene id: 9615:FAT2
uniprot id: A0A8C0QBQ2
uniprot id: A0A8P0SLW4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PLIN2
gene id: 9615:PLIN2
uniprot id: A0A8C0MGR0
uniprot id: A0A8I3NVF1
names: Similarity
messages: Belongs to the perilipin family.

9615:SPCS3
gene id: 9615:SPCS3
uniprot id: P61008
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS3 family.
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SEC11A or SEC11C and SPCS1 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473, PubMed:8444896). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).
messages: Occurs in 2 differentially glycosylated forms (22 kDa and 23 kDa).

9615:PSMC4
gene id: 9615:PSMC4
uniprot id: A0A8C0SF08
uniprot id: A0A8I3MR89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9615:PGAP1
gene id: 9615:PGAP1
uniprot id: A0A8C0TAQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9615:ZDHHC5
gene id: 9615:ZDHHC5
uniprot id: Q2THW9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated (By similarity). Palmitoylation of the C-terminal tail regulates stimulation-dependent plasma membrane motility (By similarity).
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Cell membrane
messages: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, fatty acid uptake, bacterial sensing or cardiac functions. Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins. Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2. Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2. Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes. Participates also in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane. Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis.
messages: Phosphorylation regulates association with endocytic proteins and its subcellular localization. Phosphorylation by LYN during fatty acid uptake leads to inactivation of the activity.
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:LOC102156144
gene id: 9615:LOC102156144
uniprot id: A0A8C0RTK4
uniprot id: A0A8I3Q6L4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9615:SLC25A30
gene id: 9615:SLC25A30
uniprot id: A0A8I3NB12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:ANKS1B
gene id: 9615:ANKS1B
uniprot id: A0A8C0RNA6
uniprot id: A0A8I3SAZ4
names: Subcellular Location Annotation
messages: Cytoplasm

9615:TSHB
gene id: 9615:TSHB
uniprot id: P54828
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Indispensable for the control of thyroid structure and metabolism.
messages: Secreted

9615:REN
gene id: 9615:REN
uniprot id: Q6DYE7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.
messages: Interacts with ATP6AP2.
messages: Membrane
messages: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
messages: Secreted

9615:GNA14
gene id: 9615:GNA14
uniprot id: A0A8C0RAR4
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9615:GUCY2D
gene id: 9615:GUCY2D
uniprot id: O19179
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by GUCA1A when free calcium ions concentration is low, and inhibited by GUCA1A when free calcium ions concentration is high (By similarity). Negatively regulated by RD3; RD3 inhibits the basal and GUCA1A-stimulated guanylate cyclase activity (By similarity).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane.
messages: Endoplasmic reticulum membrane
messages: Expressed in retina. Low expression in cerebrum (occipital lobe).
messages: Homodimer; requires homodimerization for guanylyl cyclase activity (By similarity). Interacts (via C-terminus) with RD3 (via C-terminus); promotes the exit of GUCY2D from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (By similarity). Interaction with RD3 negatively regulates GUCY2D guanylate cyclase activity (By similarity).
messages: Photoreceptor outer segment membrane
messages: There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

9615:NME6
gene id: 9615:NME6
uniprot id: A0A8I3N546
names: Similarity
messages: Belongs to the NDK family.

9615:INPP5A
gene id: 9615:INPP5A
uniprot id: Q29467
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.
messages: Cell membrane
messages: Inhibited by EDTA and 2,3-bisphosphoglycerate.
messages: Interacts with TASOR.
messages: Isoprenylation at Cys-409 is required for localization at the membrane.
messages: Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8198557). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).
messages: dendrite

9615:PLA2G4A
gene id: 9615:PLA2G4A
uniprot id: A0A8C0LRN9
uniprot id: A0A8C0LS56
uniprot id: A0A8I3MZB9
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9615:CA3
gene id: 9615:CA3
uniprot id: A0A8C0RFT9
uniprot id: A0A8I3P452
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9615:RACK1
gene id: 9615:RACK1
uniprot id: A0A8C0N4R3
uniprot id: A0A8I3RSQ2
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

9615:KLHL21
gene id: 9615:KLHL21
uniprot id: A0A8C0MLH8
uniprot id: A0A8I3PSB9
names: Subcellular Location Annotation
messages: spindle

9615:AMIGO1
gene id: 9615:AMIGO1
uniprot id: A0A8C0N4Z3
uniprot id: A0A8I3MLU9
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9615:NKIRAS1
gene id: 9615:NKIRAS1
uniprot id: A0A8C0TKR2
uniprot id: A0A8I3NZV3
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9615:PSKH1
gene id: 9615:PSKH1
uniprot id: A0A8C0SKM7
uniprot id: A0A8I3RUI7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:SERINC5
gene id: 9615:SERINC5
uniprot id: A0A8C0Q3V3
uniprot id: A0A8I3RT14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

9615:TRMT1L
gene id: 9615:TRMT1L
uniprot id: A0A8C0M1H0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

9615:H3-3B
gene id: 9615:H3-3B
uniprot id: A0A8C0LQ69
uniprot id: E2R6K5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:USP30
gene id: 9615:USP30
uniprot id: A0A8C0TKP5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9615:NECAP1
gene id: 9615:NECAP1
uniprot id: A0A8C0P5X9
uniprot id: A0A8P0P353
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9615:NAT10
gene id: 9615:NAT10
uniprot id: A0A8C0P9F5
uniprot id: A0A8I3PQ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9615:ELF4
gene id: 9615:ELF4
uniprot id: A0A8C0TE87
uniprot id: A0A8I3Q642
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:CLDN7
gene id: 9615:CLDN7
uniprot id: A0A8C0N749
uniprot id: A0A8I3PKL1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:B4GALT4
gene id: 9615:B4GALT4
uniprot id: B2G3R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9615:FMC1
gene id: 9615:FMC1
uniprot id: A0A8C0S2H4
uniprot id: A0A8I3Q6B8
names: Similarity
messages: Belongs to the FMC1 family.

9615:NUPR1
gene id: 9615:NUPR1
uniprot id: A0A8C0Q1Q4
uniprot id: A0A8I3RS39
names: Similarity
messages: Belongs to the NUPR family.

9615:TG
gene id: 9615:TG
uniprot id: Q1ERT3
names: Caution
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:HUS1
gene id: 9615:HUS1
uniprot id: A0A8C0QC45
uniprot id: A0A8I3PT03
names: Similarity
messages: Belongs to the HUS1 family.

9615:AQP11
gene id: 9615:AQP11
uniprot id: A0A8C0SLL9
uniprot id: A0A8I3N7P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Cell membrane
messages: Membrane

9615:IL26
gene id: 9615:IL26
uniprot id: A0A8C0TGM1
uniprot id: F6Y6M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9615:TSR3
gene id: 9615:TSR3
uniprot id: A0A8C0Q020
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MRPS11
gene id: 9615:MRPS11
uniprot id: A0A8I3N602
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9615:CSK
gene id: 9615:CSK
uniprot id: A0A8C0RH82
uniprot id: A0A8P0NJE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:TNFSF8
gene id: 9615:TNFSF8
uniprot id: A0A8C0QH86
uniprot id: E2R8I1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:TEX13D
gene id: 9615:TEX13D
uniprot id: A0A8C0T025
uniprot id: A0A8I3PSM1
names: Similarity
messages: Belongs to the TEX13 family.

9615:MYB
gene id: 9615:MYB
uniprot id: A0A8C0M930
uniprot id: A0A8C0MAR7
uniprot id: A0A8C0RV16
uniprot id: A0A8I3MZK9
names: Subcellular Location Annotation
messages: Nucleus

9615:SRP9
gene id: 9615:SRP9
uniprot id: A0A8C0SEN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9615:ZPBP2
gene id: 9615:ZPBP2
uniprot id: A0A8C0RV58
uniprot id: A0A8I3NF15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

9615:KRT12
gene id: 9615:KRT12
uniprot id: A0A8C0SGN9
uniprot id: A3RF35
names: Similarity
messages: Belongs to the intermediate filament family.

9615:GPHN
gene id: 9615:GPHN
uniprot id: A0A8C0RMK8
uniprot id: A0A8I3MNZ6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9615:SLC35C2
gene id: 9615:SLC35C2
uniprot id: A0A8C0QD29
uniprot id: A0A8I3NX77
names: Subcellular Location Annotation
messages: Membrane

9615:MRRF
gene id: 9615:MRRF
uniprot id: A0A8I3RXP7
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9615:ZNF496
gene id: 9615:ZNF496
uniprot id: A0A8C0SRJ0
uniprot id: A0A8P0SFL5
names: Subcellular Location Annotation
messages: Nucleus

9615:RPS6KA2
gene id: 9615:RPS6KA2
uniprot id: A0A8C0MT56
uniprot id: A0A8C0REI3
uniprot id: A0A8P0PC03
uniprot id: A0A8P0T3S5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9615:RPSA
gene id: 9615:RPSA
uniprot id: A0A8C0N0T1
uniprot id: A0A8I3NYW8
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9615:GTF3C5
gene id: 9615:GTF3C5
uniprot id: A0A8P0SNI4
names: Subcellular Location Annotation
messages: Nucleus

9615:LOC474850
gene id: 9615:LOC474850
uniprot id: A0A8P0N3U3
uniprot id: A0A8P0N501
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9615:TCEAL1
gene id: 9615:TCEAL1
uniprot id: A0A8C0NYQ5
uniprot id: A0A8I3PIM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: Nucleus

9615:SESN2
gene id: 9615:SESN2
uniprot id: A0A8C0RWH4
uniprot id: A0A8I3NDS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9615:CEMIP2
gene id: 9615:CEMIP2
uniprot id: A0A8I3RQN5
names: Similarity
messages: Belongs to the CEMIP family.

9615:GDF9
gene id: 9615:GDF9
uniprot id: D0F1P5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9615:DPEP1
gene id: 9615:DPEP1
uniprot id: A0A8I3MKM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
messages: Membrane

9615:EIF4E2
gene id: 9615:EIF4E2
uniprot id: A0A8C0TQV7
uniprot id: A0A8I3PNW0
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9615:TUBB4B
gene id: 9615:TUBB4B
uniprot id: A0A8C0MG20
uniprot id: A0A8I3PJ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:PRKACA
gene id: 9615:PRKACA
uniprot id: Q8MJ44
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2. Activates cAMP-sensitive PKAI and PKAII holoenzymes by interacting with regulatory subunit (R) of PKA, PRKAR1A/PKR1 and PRKAR2A/PKR2, respectively. Interacts with NFKB1, NFKB2 and NFKBIA in platelets; these interactions are disrupted by thrombin and collagen. Binds to ABL1 in spermatozoa and with CDC25B in oocytes (By similarity). Interacts with APOBEC3G and AICDA (By similarity). Interacts with RAB13; downstream effector of RAB13 involved in tight junction assembly. Found in a complex at least composed of MROH2B, PRKACA and TCP11 (By similarity). Interacts with MROH2B (By similarity). Interacts with HSF1 (By similarity). Interacts with TCP11 (By similarity). Interacts with TBC1D31; in the regulation of OFD1 (By similarity).
messages: Allosterically activated by various compounds, including ATP. Activated by cAMP; the nucleotide acts as a dynamic and allosteric activator by coupling the two lobes of apo PKA, enhancing the enzyme dynamics synchronously and priming it for catalysis.
messages: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.
messages: Autophosphorylated. Phosphorylation is enhanced by vitamin K(2). Phosphorylated on threonine and serine residues. Phosphorylation on Thr-197 is required for full activity (By similarity).
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylates a large number of substrates in the cytoplasm and the nucleus (By similarity). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (By similarity). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (By similarity). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (By similarity). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By simil…
messages: Ubiquitously expressed in mammalian tissues.
messages: acrosome
messages: flagellum

9615:PTK2B
gene id: 9615:PTK2B
uniprot id: A0A8C0PBH0
uniprot id: A0A8I3RYS0
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9615:CDKN1B
gene id: 9615:CDKN1B
uniprot id: A0A8C0NMF9
uniprot id: F1PGU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

9615:SLC2A12
gene id: 9615:SLC2A12
uniprot id: A0A8I3MPM4
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9615:CRYBB3
gene id: 9615:CRYBB3
uniprot id: A0A8C0RU73
uniprot id: A0A8I3Q2C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9615:C26H12orf43
gene id: 9615:C26H12orf43
uniprot id: A0A8C0PLD3
uniprot id: A0A8P0PJ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

9615:ACTL6A
gene id: 9615:ACTL6A
uniprot id: A0A8C0T696
names: Similarity
messages: Belongs to the actin family.

9615:CNOT8
gene id: 9615:CNOT8
uniprot id: A0A8C0QJZ8
uniprot id: A0A8I3MRJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9615:PIK3CD
gene id: 9615:PIK3CD
uniprot id: A0A8C0MJU5
uniprot id: A0A8I3Q525
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9615:OR7E24
gene id: 9615:OR7E24
uniprot id: G3FJE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:RND3
gene id: 9615:RND3
uniprot id: A0A8C0N9V6
uniprot id: A0A8I3N3Z7
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9615:FRK
gene id: 9615:FRK
uniprot id: A0A8C0S8P9
uniprot id: A0A8I3PE71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:CHRNB2
gene id: 9615:CHRNB2
uniprot id: A0A8I3NJ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:SLC22A18
gene id: 9615:SLC22A18
uniprot id: A0A8C0PH66
uniprot id: A0A8I3NJX9
names: Subcellular Location Annotation
messages: Membrane

9615:CD34
gene id: 9615:CD34
uniprot id: Q28270
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CD34 family.
messages: Highly glycosylated.
messages: Membrane
messages: On early hematopoietic progenitor cells.
messages: Phosphorylated on serine residues by PKC.
messages: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity).
messages: Selectively expressed on hematopoietic progenitor cells and vascular endothelium.

9615:ETV3
gene id: 9615:ETV3
uniprot id: A0A8C0RB10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

9615:CPSF2
gene id: 9615:CPSF2
uniprot id: A0A8C0LT83
uniprot id: A0A8I3PD41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9615:DAG1
gene id: 9615:DAG1
uniprot id: Q9TSZ6
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autolytic cleavage produces the alpha and beta subunits. In cutaneous cells, as well as in certain pathological conditions, shedding of beta-dystroglycan can occur releasing a peptide of about 30 kDa (By similarity).
messages: Cell membrane
messages: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells (By similarity). Also acts as a receptor for laminin LAMA5 (By similarity).
messages: Monomer. Heterodimer of alpha- and beta-dystroglycan subunits which are the central components of the dystrophin-glycoprotein complex. This complex then can form a dystrophin-associated glycoprotein complex (DGC) which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts (via the N-terminal of alphaDAG1) with LARGE1; the interaction enhances laminin binding (By similarity). Interacts with SGCD. Interacts with AGR2 and AGR3. Interacts (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif. Interacts (betaDAG1, via its PPXY motif) with UTRN (via its WWW and ZZ domains); the interaction is inhibited by phosphorylation on the PPXY motif. Interacts (betaDAG1, via its phosphorylated PPXY motif) with the SH2 domain-containing proteins, FYN, CSK, NCK and SHC. Interacts (betaDAG1) with CAV3 (via a central WW-like domain); the interaction disrupts the binding of DMD. BetaDAG1 directly interacts with ANK3, but not with ANK2; this interaction does not interfere with DMD-binding and is required for retention at costameres (By similarity). Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity). Interacts with POMGNT1 (By similarity).
messages: N-glycosylated.
messages: O-glycosylated. POMGNT1 catalyzes the initial addition of N-acetylglucosamine, giving rise to the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety and thus providing the necessary basis for the addition of further carbohydrate moieties. Heavily O-glycosylated comprising of up to two thirds of its mass and the carbohydrate composition differs depending on tissue type. Mucin-type O-glycosylation is important for ligand binding activity. O-mannosylation is found in high abundance in both brain and muscle where the most abundant glycan is Sia-alpha-2-3-Gal-beta-1-4-Glc-NAc-beta-1-2-Man. In muscle, glycosylation on Thr-314, Thr-316 and Thr-376 by a phosphorylated O-mannosyl glycan with the structure 2-(N-acetylamido)-2-deoxygalactosyl-beta-1,3-2-(N-acetylamido)-2-deoxyglucosyl-beta-1,4-6-phosphomannose is mediated by like-acetylglucosaminyltransferase (LARGE1) protein amd is required for laminin binding. O-glycosylated in the N-terminal region with a core 1 or possibly core 8 glycan. The brain form displays a unique glycosylation pattern which is absent in other tissues; this form shows enhanced binding to laminin LAMA5 compared to the skeletal muscle form (By similarity).
messages: Postsynaptic cell membrane
messages: SRC-mediated phosphorylation of the PPXY motif of the beta subunit recruits SH2 domain-containing proteins, but inhibits binding to WWW domain-containing proteins, DMD and UTRN. This phosphorylation also inhibits nuclear entry (By similarity).
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity).
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9615:WIPI2
gene id: 9615:WIPI2
uniprot id: A0A8C0NEH5
uniprot id: A0A8I3NP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure membrane

9615:ERH
gene id: 9615:ERH
uniprot id: A0A8C0RKE5
uniprot id: A0A8I3RRU1
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9615:IKBKB
gene id: 9615:IKBKB
uniprot id: A0A8I3N4F2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:BET1
gene id: 9615:BET1
uniprot id: A0A8C0SAE2
uniprot id: A0A8I3NV66
names: Subcellular Location Annotation
messages: Membrane

9615:THTPA
gene id: 9615:THTPA
uniprot id: A0A8I3MTM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9615:PORCN
gene id: 9615:PORCN
uniprot id: A0A8C0T3R8
uniprot id: A0A8C0T5T0
uniprot id: A0A8C0Z275
uniprot id: A0A8I3Q7P5
uniprot id: A0A8I3QBN8
uniprot id: A0A8I3QCY6
names: Subcellular Location Annotation
messages: Membrane

9615:PHGDH
gene id: 9615:PHGDH
uniprot id: A0A8C0SMF7
uniprot id: A0A8I3N4A3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9615:ARMCX1
gene id: 9615:ARMCX1
uniprot id: A0A8C0MNI4
uniprot id: A0A8I3NZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9615:RAB3D
gene id: 9615:RAB3D
uniprot id: A0A8C0SV76
uniprot id: A0A8I3P6T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9615:CYP4A37
gene id: 9615:CYP4A37
uniprot id: Q2VHZ9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:CELF3
gene id: 9615:CELF3
uniprot id: A0A8C0YYR3
uniprot id: A0A8P0SHN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9615:MRPS5
gene id: 9615:MRPS5
uniprot id: A0A8C0QJD2
uniprot id: A0A8I3N577
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9615:PAF1
gene id: 9615:PAF1
uniprot id: A0A8I3MY63
names: Similarity
messages: Belongs to the PAF1 family.

9615:PDCL
gene id: 9615:PDCL
uniprot id: A0A8C0MBY4
uniprot id: A0A8I3NFA9
names: Similarity
messages: Belongs to the phosducin family.

9615:WDR12
gene id: 9615:WDR12
uniprot id: A0A8I3P0V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9615:GPR18
gene id: 9615:GPR18
uniprot id: A0A8C0MFA6
uniprot id: A0A8I3PH14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9615:PARP6
gene id: 9615:PARP6
uniprot id: A0A8C0RM34
uniprot id: A0A8I3PHV5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:EDIL3
gene id: 9615:EDIL3
uniprot id: A0A8C0MHS7
uniprot id: A0A8C0Q139
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:VSX2
gene id: 9615:VSX2
uniprot id: A0A8C0S8C2
uniprot id: A0A8I3NIJ9
names: Subcellular Location Annotation
messages: Nucleus

9615:TBC1D23
gene id: 9615:TBC1D23
uniprot id: A0A8C0TIW1
uniprot id: A0A8I3NUA0
names: Subcellular Location Annotation
messages: trans-Golgi network

9615:LOC610388
gene id: 9615:LOC610388
uniprot id: A0A8C0PIL2
uniprot id: A0A8I3PU98
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9615:LOC106558887
gene id: 9615:LOC106558887
uniprot id: A0A8C0P073
uniprot id: E2QZG2
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9615:METTL6
gene id: 9615:METTL6
uniprot id: A0A8I3PVU1
uniprot id: A0A8I3PZN4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9615:CCL24
gene id: 9615:CCL24
uniprot id: Q68Y86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.
messages: Secreted

9615:HMGCS1
gene id: 9615:HMGCS1
uniprot id: A0A8I3MM03
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9615:SLC25A34
gene id: 9615:SLC25A34
uniprot id: A0A8C0Q6K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:IVL
gene id: 9615:IVL
uniprot id: A0A8C0NQ79
uniprot id: A0A8P0SQE3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the involucrin family.
messages: Cytoplasm
messages: Directly or indirectly cross-linked to cornifelin (CNFN).
messages: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
messages: Substrate of transglutaminase.

9615:APMAP
gene id: 9615:APMAP
uniprot id: A0A8C0P4B0
uniprot id: A0A8I3Q5F9
names: Similarity
messages: Belongs to the strictosidine synthase family.

9615:TAF13
gene id: 9615:TAF13
uniprot id: A0A8C0T7V3
uniprot id: E2QZK3
names: Subcellular Location Annotation
messages: Nucleus

9615:CD52
gene id: 9615:CD52
uniprot id: Q28896
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Epididymis. Highest levels are found in the distal corpus and cauda. Little or no expression in the caput and proximal cauda regions.
messages: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

9615:BTF3L4
gene id: 9615:BTF3L4
uniprot id: A0A8C0RJY7
uniprot id: A0A8I3PJG4
uniprot id: A0A8I3PLS1
names: Similarity
messages: Belongs to the NAC-beta family.

9615:CLDN10
gene id: 9615:CLDN10
uniprot id: A0A8C0NKV8
uniprot id: A0A8C0YYM4
uniprot id: A0A8I3N615
uniprot id: A0A8P0PDB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:APOC3
gene id: 9615:APOC3
uniprot id: A0A8C0Q7Q3
uniprot id: A0A8I3MTA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

9615:P2RY1
gene id: 9615:P2RY1
uniprot id: A0A8C0N762
uniprot id: Q5XX73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:SMAD2
gene id: 9615:SMAD2
uniprot id: A0A8C0RP35
uniprot id: A0A8I3MFT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9615:NUF2
gene id: 9615:NUF2
uniprot id: A0A8C0S2W9
uniprot id: A0A8I3S9L8
names: Similarity
messages: Belongs to the NUF2 family.

9615:CAD
gene id: 9615:CAD
uniprot id: A0A8C0MM07
uniprot id: A0A8C0QRL7
uniprot id: A0A8P0P4F4
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

9615:LOC102155410
gene id: 9615:LOC102155410
uniprot id: A0A8C0Q8S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9615:IDH3G
gene id: 9615:IDH3G
uniprot id: A0A8I3Q6D6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9615:CNOT7
gene id: 9615:CNOT7
uniprot id: A0A8C0RZF1
uniprot id: A0A8I3NXC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9615:THBS2
gene id: 9615:THBS2
uniprot id: D5IGC9
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PSMB4
gene id: 9615:PSMB4
uniprot id: A0A8C0MRG6
uniprot id: A0A8I3PII7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9615:HTR7
gene id: 9615:HTR7
uniprot id: A0A8C0NZQ1
uniprot id: A0A8I3S709
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:MGAT5
gene id: 9615:MGAT5
uniprot id: A0A8C0P0I8
uniprot id: A0A8P0N7U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9615:EXOC1
gene id: 9615:EXOC1
uniprot id: A0A8C0NWK2
uniprot id: A0A8C0RPG7
uniprot id: A0A8C0SV64
uniprot id: A0A8C0SWE1
uniprot id: A0A8I3NE87
uniprot id: A0A8I3NMX3
uniprot id: A0A8I3NMX9
uniprot id: A0A8I3NYD8
names: Similarity
messages: Belongs to the SEC3 family.

9615:KIF7
gene id: 9615:KIF7
uniprot id: A0A8P0NDZ8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:PIGK
gene id: 9615:PIGK
uniprot id: A0A8C0PPF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

9615:VPS52
gene id: 9615:VPS52
uniprot id: Q5TJF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
messages: Belongs to the VPS52 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin. EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network. Interacts with RAB6A and STX10. Interacts with BLTP3B.
messages: Endosome membrane
messages: Recycling endosome
messages: trans-Golgi network membrane

9615:ZNF287
gene id: 9615:ZNF287
uniprot id: A0A8C0RUR6
uniprot id: A0A8I3MTF6
names: Subcellular Location Annotation
messages: Nucleus

9615:TXNIP
gene id: 9615:TXNIP
uniprot id: A0A8C0QFP6
uniprot id: A0A8P0SGB3
names: Similarity
messages: Belongs to the arrestin family.

9615:PRKCD
gene id: 9615:PRKCD
uniprot id: Q5PU49
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated and/or phosphorylated at Thr-505, within the activation loop; phosphorylation at Thr-505 is not a prerequisite for enzymatic activity. Autophosphorylated at Ser-299 and Ser-302. Upon TNFSF10/TRAIL treatment, phosphorylated at Tyr-155; phosphorylation is required for its translocation to the endoplasmic reticulum and cleavage by caspase-3. Phosphorylated at Tyr-310, Tyr-332 and Tyr-565; phosphorylation of Tyr-310 and Tyr-565 following thrombin or zymosan stimulation potentiates its kinase activity. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylated at Tyr-310 through a SYK and SRC mechanism downstream of C-type lectin receptors activation, promoting its activation (By similarity).
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subseq…
messages: Cell membrane
messages: Cytoplasm
messages: Endomembrane system
messages: Interacts with PDPK1 (via N-terminal region). Interacts with RAD9A (By similarity). Interacts with CDCP1. Interacts with MUC1. Interacts with VASP. Interacts with CAVIN3. Interacts with PRKD2 (via N-terminus and zing-finger domain 1 and 2) in response to oxidative stress; the interaction is independent of PRKD2 tyrosine phosphorylation (By similarity). Interacts with PLSC3; interaction is enhanced by UV irradiation (By similarity).
messages: Mitochondrion
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-505 (activation loop of the kinase domain), Ser-643 (turn motif) and Ser-662 (hydrophobic region), need to be phosphorylated for its full activation. Activated by caspase-3 (CASP3) cleavage during apoptosis. After cleavage, the pseudosubstrate motif in the regulatory subunit is released from the substrate recognition site of the catalytic subunit, which enables PRKCD to become constitutively activated. The catalytic subunit which displays properties of a sphingosine-dependent protein kinase is activated by D-erythro-sphingosine (Sph) or N,N-dimethyl-D-erythrosphingosine (DMS) or N,N,N-trimethyl-D-erythrosphingosine (TMS), but not by ceramide or Sph-1-P and is strongly inhibited by phosphatidylserine (By similarity).
messages: Nucleus
messages: Proteolytically cleaved into a catalytic subunit and a regulatory subunit by caspase-3 during apoptosis which results in kinase activation.
messages: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor.
messages: The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner (By similarity).
messages: perinuclear region

9615:GLG1
gene id: 9615:GLG1
uniprot id: A0A8C0SKW4
uniprot id: A0A8P0NM97
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

9615:CDC34
gene id: 9615:CDC34
uniprot id: A0A8C0SC16
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:USP33
gene id: 9615:USP33
uniprot id: A0A8I3RRN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9615:ST6GALNAC6
gene id: 9615:ST6GALNAC6
uniprot id: A0A8C0N2V0
uniprot id: A0A8I3NB27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:H2BC14
gene id: 9615:H2BC14
uniprot id: A0A8C0P6N2
uniprot id: H9GWB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:ATG4D
gene id: 9615:ATG4D
uniprot id: A0A8C0TCA3
uniprot id: E2RDP2
names: Activity Regulation
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondrial import of the protein.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (By similarity). ATG4D plays a role in the autophagy-mediated neuronal homeostasis in the central nervous system (PubMed:25875846). Compared to other members of the family (ATG4A, ATG4B or ATG4C), constitutes the major protein for the delipidation activity, while it promotes weak proteolytic activation of ATG8 proteins (By similarity). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (By similarity).
messages: Cytoplasm
messages: Defects in ATG4D are the cause of a neurodegenerative disease present in the Lagotto Romagnolo dog breed (PubMed:25875846). Affected dogs suffer from progressive cerebellar ataxia, sometimes accompanied by episodic nystagmus and behavioral changes (PubMed:25875846). Defects are caused by impaired autophagy: neuronal cells display cytoplasmic vacuolization in the nervous system, as well as spheroid formation and cytoplasmic aggregation of vacuoles in secretory epithelial tissues and mesenchymal cells (PubMed:25875846).
messages: Inhibited by N-ethylmaleimide.
messages: Mitochondrion matrix
messages: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
messages: The cryptic mitochondrial transit peptide is revealed after cleavage by caspase upon oxidative stress and cell death. It acts then as a functional transit peptide, and allows the import of the cleaved protein into the mitochondria.

9615:ALDH1A1
gene id: 9615:ALDH1A1
uniprot id: A0A8C0RUB5
uniprot id: A0A8I3M9Q4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:TSC22D1
gene id: 9615:TSC22D1
uniprot id: A0A8C0P8U6
uniprot id: A0A8C0SX96
uniprot id: A0A8I3N2F3
uniprot id: A0A8I3N3H3
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9615:PPM1L
gene id: 9615:PPM1L
uniprot id: A0A8C0NBX2
uniprot id: A0A8I3Q4M2
names: Similarity
messages: Belongs to the PP2C family.

9615:GPX8
gene id: 9615:GPX8
uniprot id: A0A8C0MGU0
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9615:AGBL2
gene id: 9615:AGBL2
uniprot id: A0A8P0NAR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9615:HARS2
gene id: 9615:HARS2
uniprot id: A0A8I3RS66
uniprot id: A0A8P0SXL5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9615:CHRDL1
gene id: 9615:CHRDL1
uniprot id: A0A8C0NVX0
names: Subcellular Location Annotation
messages: Secreted

9615:CD164L2
gene id: 9615:CD164L2
uniprot id: A0A8C0N1I0
uniprot id: A0A8P0NM14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9615:SGCB
gene id: 9615:SGCB
uniprot id: A0A8C0SJC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

9615:SNX21
gene id: 9615:SNX21
uniprot id: A0A8I3NMW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9615:FOXA3
gene id: 9615:FOXA3
uniprot id: A0A8C0MCB7
uniprot id: A0A8I3MX60
names: Subcellular Location Annotation
messages: Nucleus

9615:GUSB
gene id: 9615:GUSB
uniprot id: O18835
names: Activity Regulation
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Defects in GUSB are the cause of mucopolysaccharidosis type VII (MPS VII), an inherited disease reported in humans, mice, cats, and dogs.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

9615:ENY2
gene id: 9615:ENY2
uniprot id: A0A8C0S1V9
uniprot id: A0A8I3NFA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9615:ELOVL6
gene id: 9615:ELOVL6
uniprot id: A0A8C0Z609
uniprot id: A0A8I3QXG1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9615:CRSP-4
gene id: 9615:CRSP-4
uniprot id: A0A8C0T4K8
uniprot id: B3XXE9
names: Similarity
messages: Belongs to the calcitonin family.

9615:TRIM56
gene id: 9615:TRIM56
uniprot id: A0A8C0RRS9
uniprot id: A0A8I3MC17
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9615:ADCY4
gene id: 9615:ADCY4
uniprot id: A0A8C0N4S7
uniprot id: A0A8I3RTR3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9615:ELK3
gene id: 9615:ELK3
uniprot id: A0A8C0RZ25
uniprot id: A0A8I3PXT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:CRHR1
gene id: 9615:CRHR1
uniprot id: A0A8C0MRS6
uniprot id: A0A8I3PHA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
messages: Membrane

9615:ELOVL1
gene id: 9615:ELOVL1
uniprot id: A0A8C0QDN8
uniprot id: A0A8I3P5E7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9615:OR4A47D
gene id: 9615:OR4A47D
uniprot id: F1PVC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MRPL41
gene id: 9615:MRPL41
uniprot id: A0A8C0MD63
uniprot id: A0A8I3PES4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9615:B4GALT6
gene id: 9615:B4GALT6
uniprot id: A0A8I3NRE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9615:SRD5A1
gene id: 9615:SRD5A1
uniprot id: A0A8P0P128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane
messages: Microsome membrane

9615:MC3R
gene id: 9615:MC3R
uniprot id: B5TQW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9615:NRM
gene id: 9615:NRM
uniprot id: A0A8C0REE3
uniprot id: A0A8I3N6N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9615:ACSM3
gene id: 9615:ACSM3
uniprot id: A0A8I3N6J5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:EEF1A1
gene id: 9615:EEF1A1
uniprot id: A0A8C0NJT4
uniprot id: F2Z4P4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9615:NECAP2
gene id: 9615:NECAP2
uniprot id: A0A8C0Q7E9
uniprot id: A0A8C0RWL7
uniprot id: A0A8I3MT64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9615:WASF2
gene id: 9615:WASF2
uniprot id: A0A8C0RWW1
uniprot id: A0A8I3RVS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9615:DBI
gene id: 9615:DBI
uniprot id: Q9TQX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ACBP family.
messages: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Monomer.

9615:SS18L2
gene id: 9615:SS18L2
uniprot id: A0A8C0NIB6
uniprot id: A0A8I3S453
names: Similarity
messages: Belongs to the SS18 family.

9615:KIN
gene id: 9615:KIN
uniprot id: A0A8C0LVP7
uniprot id: A0A8P0NQC7
names: Similarity
messages: Belongs to the KIN17 family.

9615:CEP20
gene id: 9615:CEP20
uniprot id: A0A8C0PT45
uniprot id: A0A8C0PXG3
uniprot id: A0A8P0PR53
uniprot id: A0A8P0SRI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9615:NPNT
gene id: 9615:NPNT
uniprot id: A0A8C0PEW3
uniprot id: A0A8C0PEX3
uniprot id: A0A8C0PFG6
uniprot id: A0A8I3Q0H8
uniprot id: A0A8I3QG70
uniprot id: A0A8I3SBG5
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:UCMA
gene id: 9615:UCMA
uniprot id: A0A8C0PZL8
uniprot id: A0A8I3P8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

9615:OR14J1
gene id: 9615:OR14J1
uniprot id: A0A8P0NGK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SPP2
gene id: 9615:SPP2
uniprot id: A0A8C0NXJ1
uniprot id: A0A8P0SGR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Secreted

9615:IDH3A
gene id: 9615:IDH3A
uniprot id: A0A8C0MAD2
uniprot id: A0A8I3NG17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9615:FAM53C
gene id: 9615:FAM53C
uniprot id: A0A8C0MC34
names: Similarity
messages: Belongs to the FAM53 family.

9615:RNF34
gene id: 9615:RNF34
uniprot id: A0A8C0PAX6
names: Subcellular Location Annotation
messages: Cell membrane

9615:CLEC12A
gene id: 9615:CLEC12A
uniprot id: A0A8P0NFF1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:PLK4
gene id: 9615:PLK4
uniprot id: A0A8C0MR22
uniprot id: A0A8I3SAH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cleavage furrow
messages: centriole

9615:PTTG1
gene id: 9615:PTTG1
uniprot id: A0A8C0RJL2
uniprot id: A0A8I3MGC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9615:SSU72
gene id: 9615:SSU72
uniprot id: A0A8C0PZW1
uniprot id: A0A8I3NWC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9615:LOC102155800
gene id: 9615:LOC102155800
uniprot id: A0A8C0YV22
uniprot id: A0A8I3PUU5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9615:CUL7
gene id: 9615:CUL7
uniprot id: A0A8P0N4X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9615:GTF2A2
gene id: 9615:GTF2A2
uniprot id: A0A8C0N187
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9615:HRH4
gene id: 9615:HRH4
uniprot id: A0A8I3NPW0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:GALK1
gene id: 9615:GALK1
uniprot id: Q9GKK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of a phosphate from ATP to alpha-D-galactose and participates in the first committed step in the catabolism of galactose.
messages: Homodimer.

9615:PSMD9
gene id: 9615:PSMD9
uniprot id: A0A8C0Z089
uniprot id: A0A8I3PMA2
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9615:RAD1
gene id: 9615:RAD1
uniprot id: A0A8C0LY53
uniprot id: A0A8I3MH43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9615:GCNT3
gene id: 9615:GCNT3
uniprot id: A0A8I3P593
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9615:ZW10
gene id: 9615:ZW10
uniprot id: A0A8C0Q002
uniprot id: A0A8I3RP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

9615:EIF5A
gene id: 9615:EIF5A
uniprot id: A0A8C0RIV2
uniprot id: A0A8I3PFB8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

9615:YPEL3
gene id: 9615:YPEL3
uniprot id: A0A8C0LZ46
uniprot id: A0A8I3MJ16
names: Similarity
messages: Belongs to the yippee family.

9615:STAT6
gene id: 9615:STAT6
uniprot id: A0A0I9QQS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9615:PGAM1
gene id: 9615:PGAM1
uniprot id: A0A8C0RRN5
uniprot id: A0A8I3SC19
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9615:STX5
gene id: 9615:STX5
uniprot id: A0A8C0MMT1
uniprot id: A0A8I3N2I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9615:COG8
gene id: 9615:COG8
uniprot id: A0A8C0S384
uniprot id: A0A8I3NBG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

9615:DMRTA1
gene id: 9615:DMRTA1
uniprot id: A0A8P0S7K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9615:PIH1D2
gene id: 9615:PIH1D2
uniprot id: A0A8C0N884
uniprot id: A0A8P0NRH8
names: Similarity
messages: Belongs to the PIH1 family.

9615:CPT1B
gene id: 9615:CPT1B
uniprot id: A0A8P0S6S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:ATG2B
gene id: 9615:ATG2B
uniprot id: A0A8C0MWZ1
uniprot id: A0A8P0SLX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9615:NAV2
gene id: 9615:NAV2
uniprot id: A0A8I3P2L4
uniprot id: A0A8I3P705
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9615:MAT2B
gene id: 9615:MAT2B
uniprot id: A0A8C0NUP6
uniprot id: A0A8C0PUB6
uniprot id: A0A8I3MF25
uniprot id: A0A8I3RP35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9615:SUSD6
gene id: 9615:SUSD6
uniprot id: A0A8C0NJZ1
uniprot id: A0A8I3RRV5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SUMO2
gene id: 9615:SUMO2
uniprot id: A0A8C0Q4G0
uniprot id: A0A8I3Q1K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9615:DDOST
gene id: 9615:DDOST
uniprot id: Q05052
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:12887896, PubMed:15835887, PubMed:25135935). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:15835887, PubMed:29519914). Interacts with SMIM22 (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:12887896). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).

9615:HCCS
gene id: 9615:HCCS
uniprot id: A0A8C0MP16
uniprot id: A0A8P0NDI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9615:UBAC2
gene id: 9615:UBAC2
uniprot id: A0A8I3P9G5
names: Subcellular Location Annotation
messages: Membrane

9615:NEURL2
gene id: 9615:NEURL2
uniprot id: A0A8C0QCJ2
uniprot id: A0A8I3P462
names: Subcellular Location Annotation
messages: Cytoplasm

9615:SLCO1A2
gene id: 9615:SLCO1A2
uniprot id: A0A8I3NXT1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:CARTPT
gene id: 9615:CARTPT
uniprot id: A0A8C0QHC6
uniprot id: A0A8I3MHA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9615:CRYGD
gene id: 9615:CRYGD
uniprot id: A0A8C0MWI8
uniprot id: A9JPX7
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9615:LOC403934
gene id: 9615:LOC403934
uniprot id: P60952
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with DOCK11/Zizimin2; the interaction activates CDC42 by exchanging GDP for GTP. Interacts with DOCK9; the interaction activates CDC42 by exchanging GDP for GTP. Interacts with DOCK8 (via DHR-2 domain); the interaction activates CDC42 by exchanging GDP for GTP. Interacts with IQGAP1. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. The GTP-bound form interacts with CCPG1. Interacts with USP6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with ITGB1BP1. Interacts with ARHGDIA; this interaction inactivates and stabilizes CDC42. Interacts with ARHGDIB; this maintains CDC42 in the inactive, GDP-bound form. Interacts in (GTP-bound form) with FNBP1L and ABI1, but only in the presence of FNBP1L.
messages: Midbody
messages: Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI.
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity).
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
messages: centrosome
messages: dendrite
messages: lamellipodium membrane
messages: spindle

9615:GPR68
gene id: 9615:GPR68
uniprot id: A0A8C0LT23
uniprot id: A0A8I3NKP7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:CAMK2D
gene id: 9615:CAMK2D
uniprot id: A0A8C0PCX9
uniprot id: A0A8C0RPG2
uniprot id: A0A8C0RPZ7
uniprot id: A0A8C0TWG0
uniprot id: A0A8C0Z6Z6
uniprot id: A0A8I3Q1E3
uniprot id: A0A8I3Q5E5
uniprot id: A0A8I3QQ41
uniprot id: A0A8I3QQ80
uniprot id: A0A8P0P1E5
uniprot id: A0A8P0PKQ0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9615:DPH5
gene id: 9615:DPH5
uniprot id: A0A8I3NBJ4
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9615:PRKCQ
gene id: 9615:PRKCQ
uniprot id: A0A8C0LSI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9615:P2RX7
gene id: 9615:P2RX7
uniprot id: A0A8C0PB41
uniprot id: B0FLR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9615:TPM3
gene id: 9615:TPM3
uniprot id: A0A8C0Q2Y0
uniprot id: A0A8P0NIT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9615:SPHKAP
gene id: 9615:SPHKAP
uniprot id: A0A8I3P3B0
names: Similarity
messages: Belongs to the AKAP110 family.

9615:SOX6
gene id: 9615:SOX6
uniprot id: A0A8C0PFH4
uniprot id: A0A8C0PIZ9
names: Subcellular Location Annotation
messages: Nucleus

9615:MRPS16
gene id: 9615:MRPS16
uniprot id: A0A8P0PHL1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9615:OR6C89
gene id: 9615:OR6C89
uniprot id: G3FJD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:UTP14A
gene id: 9615:UTP14A
uniprot id: A0A8C0TBV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9615:TIMP4
gene id: 9615:TIMP4
uniprot id: A0A8C0MFN7
uniprot id: E2RPY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

9615:CHRNA9
gene id: 9615:CHRNA9
uniprot id: A0A8I3RTA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:NDUFB6
gene id: 9615:NDUFB6
uniprot id: A0A8C0QJI5
uniprot id: A0A8I3P9N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:SLC48A1
gene id: 9615:SLC48A1
uniprot id: A0A8C0PNB6
uniprot id: A0A8I3PLR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
messages: Lysosome membrane
messages: Membrane

9615:PDE6H
gene id: 9615:PDE6H
uniprot id: A0A8C0PN66
uniprot id: A0A8I3PDZ9
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9615:OSBPL1A
gene id: 9615:OSBPL1A
uniprot id: A0A8C0SU23
uniprot id: A0A8I3NPK5
names: Similarity
messages: Belongs to the OSBP family.

9615:SPPL2B
gene id: 9615:SPPL2B
uniprot id: A0A8C0MNI7
uniprot id: A0A8I3NKZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9615:ACTN3
gene id: 9615:ACTN3
uniprot id: A0A8C0NSN0
names: Similarity
messages: Belongs to the alpha-actinin family.

9615:SLC6A17
gene id: 9615:SLC6A17
uniprot id: A0A8C0NQK0
uniprot id: A0A8I3MEZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:LOC606863
gene id: 9615:LOC606863
uniprot id: A0A8C0QBH6
uniprot id: C3UZV0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9615:NFX1
gene id: 9615:NFX1
uniprot id: A0A8C0QI82
uniprot id: A0A8I3PEY7
uniprot id: A0A8I3PKM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9615:VRK1
gene id: 9615:VRK1
uniprot id: A0A8C0PUR1
uniprot id: A0A8I3MQW3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:TAF10
gene id: 9615:TAF10
uniprot id: A0A8C0Q3H0
uniprot id: A0A8I3N6Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

9615:BMP2
gene id: 9615:BMP2
uniprot id: A0A8I3PXE9
names: Similarity
messages: Belongs to the TGF-beta family.

9615:TEAD2
gene id: 9615:TEAD2
uniprot id: A0A8C0NKY9
uniprot id: A0A8I3MEV0
names: Subcellular Location Annotation
messages: Nucleus

9615:MED24
gene id: 9615:MED24
uniprot id: A0A8C0Q2Z1
uniprot id: A0A8I3N3B0
uniprot id: A0A8I3NF58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9615:LOC606786
gene id: 9615:LOC606786
uniprot id: A0A8C0SWW3
uniprot id: A0A8I3N786
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9615:GALNT18
gene id: 9615:GALNT18
uniprot id: A0A8C0SUC7
uniprot id: A0A8I3NUN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:ZDHHC6
gene id: 9615:ZDHHC6
uniprot id: A0A8C0NVK4
uniprot id: A0A8I3SCG3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:OR5I1
gene id: 9615:OR5I1
uniprot id: Q95154
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Putative odorant or sperm cell receptor.

9615:LYRM7
gene id: 9615:LYRM7
uniprot id: A0A8C0PAS5
uniprot id: A0A8I3N3Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9615:ALDH4A1
gene id: 9615:ALDH4A1
uniprot id: A0A8C0N6F0
uniprot id: A0A8P0NR41
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:DVL3
gene id: 9615:DVL3
uniprot id: A0A8C0TMQ9
uniprot id: A0A8I3PTY8
names: Similarity
messages: Belongs to the DSH family.

9615:ALDOC
gene id: 9615:ALDOC
uniprot id: A0A8C0Z329
uniprot id: A0A8I3NII5
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9615:PEX3
gene id: 9615:PEX3
uniprot id: A0A8C0PYP3
uniprot id: A0A8I3RWW4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9615:CHST12
gene id: 9615:CHST12
uniprot id: A0A8C0MJK2
uniprot id: A0A8I3MZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:TPM1
gene id: 9615:TPM1
uniprot id: A0A0N9JIB9
uniprot id: A0A8I3P7B2
uniprot id: A0A8I3PBQ8
uniprot id: A0A8I3PIT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9615:STK38
gene id: 9615:STK38
uniprot id: A0A8C0MX62
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:MRPS25
gene id: 9615:MRPS25
uniprot id: A0A8C0T4Q9
uniprot id: A0A8I3PWG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9615:VNN1
gene id: 9615:VNN1
uniprot id: Q9TSX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
messages: Cell membrane
messages: Monomer.

9615:ORMDL2
gene id: 9615:ORMDL2
uniprot id: A0A8C0N705
uniprot id: A0A8I3N0C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9615:AP3B2
gene id: 9615:AP3B2
uniprot id: A0A8C0R9P2
uniprot id: A0A8I3MQV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9615:FAM149B1
gene id: 9615:FAM149B1
uniprot id: A0A8C0RV42
uniprot id: A0A8C0RVA3
uniprot id: A0A8I3MYX7
uniprot id: A0A8P0NG84
names: Similarity
messages: Belongs to the FAM149 family.

9615:H2AC11
gene id: 9615:H2AC11
uniprot id: A0A8C0S1T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:OSBPL9
gene id: 9615:OSBPL9
uniprot id: A0A8C0MYU5
uniprot id: A0A8C0N0U2
uniprot id: A0A8C0NA03
uniprot id: A0A8I3PDY7
uniprot id: A0A8I3S5H8
names: Similarity
messages: Belongs to the OSBP family.

9615:ATP1B1
gene id: 9615:ATP1B1
uniprot id: A0A8C0PQV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
messages: sarcolemma

9615:OR7A63
gene id: 9615:OR7A63
uniprot id: A0A8P0STD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:GPR89A
gene id: 9615:GPR89A
uniprot id: A0A8C0QI31
uniprot id: A0A8I3N8Z3
uniprot id: A0A8I3RXH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9615:TEAD1
gene id: 9615:TEAD1
uniprot id: A0A8I3S448
names: Subcellular Location Annotation
messages: Nucleus

9615:EVA1B
gene id: 9615:EVA1B
uniprot id: A0A8C0NX26
names: Similarity
messages: Belongs to the EVA1 family.

9615:COPB1
gene id: 9615:COPB1
uniprot id: A0A8C0T686
uniprot id: A0A8I3PLJ3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9615:TTYH1
gene id: 9615:TTYH1
uniprot id: A0A8C0M3M7
uniprot id: A0A8C0PJT8
uniprot id: A0A8I3MKK2
uniprot id: A0A8I3MMD8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable chloride channel.

9615:CEP170
gene id: 9615:CEP170
uniprot id: A0A8P0PPD3
uniprot id: A0A8P0TMG6
names: Similarity
messages: Belongs to the CEP170 family.

9615:NLGN3
gene id: 9615:NLGN3
uniprot id: A0A8C0TR01
uniprot id: A0A8C0TSJ0
uniprot id: A0A8C0Z5U9
uniprot id: A0A8I3NS13
uniprot id: A0A8I3P427
uniprot id: A0A8I3PA84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9615:DNAJC24
gene id: 9615:DNAJC24
uniprot id: A0A8C0Z3E5
uniprot id: A0A8I3Q3L4
names: Similarity
messages: Belongs to the DPH4 family.

9615:MRPS26
gene id: 9615:MRPS26
uniprot id: A0A8C0STU7
uniprot id: A0A8I3S1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9615:HPX
gene id: 9615:HPX
uniprot id: A0A8C0T7L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

9615:RRBP1
gene id: 9615:RRBP1
uniprot id: Q28298
names: Function
names: Subcellular Location Annotation
messages: Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.
messages: Endoplasmic reticulum membrane

9615:CASP4
gene id: 9615:CASP4
uniprot id: Q9MZV7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cell membrane
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NLRP2 and whose function would be the activation of pro-inflammatory caspases. Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis). Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17P/INCA and CARD18. Interacts with SERPINB1; this interaction regulates CASP1 activity.
messages: The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
messages: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.
messages: Ubiquitinated via 'Lys-11'-linked polyubiquitination. Deubiquitinated by USP8.

9615:IFI30
gene id: 9615:IFI30
uniprot id: A0A8C0S129
uniprot id: A0A8P0SJG7
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

9615:FABP9
gene id: 9615:FABP9
uniprot id: A0A8C0T517
uniprot id: A0A8I3NVA3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:FUNDC2
gene id: 9615:FUNDC2
uniprot id: A0A8C0MPY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9615:KRT71
gene id: 9615:KRT71
uniprot id: D6BR72
names: Similarity
messages: Belongs to the intermediate filament family.

9615:GSTO1
gene id: 9615:GSTO1
uniprot id: A0A8C0PEQ0
uniprot id: A0A8I3QSL3
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9615:NAP1L3
gene id: 9615:NAP1L3
uniprot id: A0A8C0MLC8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:SLC50A1
gene id: 9615:SLC50A1
uniprot id: A0A8C0PI33
uniprot id: A0A8C0PQD3
uniprot id: A0A8I3NJZ7
uniprot id: A0A8I3NSG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9615:ANXA7
gene id: 9615:ANXA7
uniprot id: A0A8C0PPV8
uniprot id: A0A8C0PQ22
uniprot id: A0A8I3MVW5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9615:CMTM5
gene id: 9615:CMTM5
uniprot id: A0A8C0RWC2
uniprot id: A0A8I3MRY3
names: Subcellular Location Annotation
messages: Membrane

9615:RAP2C
gene id: 9615:RAP2C
uniprot id: A0A8C0TKJ8
uniprot id: A0A8I3QCP6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9615:TINAGL1
gene id: 9615:TINAGL1
uniprot id: A0A8C0P6B8
uniprot id: A0A8I3RUE7
names: Similarity
messages: Belongs to the peptidase C1 family.

9615:MCM8
gene id: 9615:MCM8
uniprot id: A0A8C0QE82
uniprot id: A0A8I3SAV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9615:PLN
gene id: 9615:PLN
uniprot id: P61012
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Heart.
messages: Homopentamer (PubMed:3753485). Interacts with HAX1. Interact with ATP2A2; the inhibition decreases ATP2A2 Ca(2+) affinity. Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with S100A1 in a Ca(2+)-dependent manner.
messages: In elongated spermatids, proteolytically cleaved by SPPL2C which modulates intracellular Ca(2+) homeostasis.
messages: Membrane
messages: Mitochondrion membrane
messages: Palmitoylated by ZDHHC16, promoting formation of the homopentamer.
messages: Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes (By similarity). Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation.
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation.
messages: Sarcoplasmic reticulum membrane

9615:HOMER3
gene id: 9615:HOMER3
uniprot id: A0A8C0THM2
uniprot id: A0A8P0SJ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9615:PPP3CC
gene id: 9615:PPP3CC
uniprot id: A0A8C0NY67
uniprot id: A0A8P0NBJ2
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9615:LOC100855634
gene id: 9615:LOC100855634
uniprot id: A0A5F4CYE6
uniprot id: A0A8C0MTB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9615:SCAMP5
gene id: 9615:SCAMP5
uniprot id: A0A8C0MWC2
uniprot id: A0A8I3P3B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9615:PPAT
gene id: 9615:PPAT
uniprot id: A0A8C0P4I5
uniprot id: A0A8P0N5A9
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9615:TMEM53
gene id: 9615:TMEM53
uniprot id: A0A8C0QF73
uniprot id: A0A8I3PRA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9615:H2BC4
gene id: 9615:H2BC4
uniprot id: A0A8C0P6N2
uniprot id: H9GWB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:DLA-DQA1
gene id: 9615:DLA-DQA1
uniprot id: A0A8C0T4C6
uniprot id: Q30410
names: Similarity
messages: Belongs to the MHC class II family.

9615:PDIK1L
gene id: 9615:PDIK1L
uniprot id: A0A8C0QHP1
uniprot id: A0A8I3NF29
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:COPS8
gene id: 9615:COPS8
uniprot id: A0A8C0T1W3
uniprot id: A0A8I3PVK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9615:PPM1F
gene id: 9615:PPM1F
uniprot id: A0A8C0PJJ6
names: Similarity
messages: Belongs to the PP2C family.

9615:SDE2
gene id: 9615:SDE2
uniprot id: A0A8C0MCV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

9615:TMOD3
gene id: 9615:TMOD3
uniprot id: A0A8I3S5X2
names: Subcellular Location Annotation
messages: cytoskeleton

9615:DLK1
gene id: 9615:DLK1
uniprot id: A0A8C0MP48
uniprot id: A0A8I3MKW6
uniprot id: A0A8I3MSX8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:JPT2
gene id: 9615:JPT2
uniprot id: A0A8C0PY96
uniprot id: A0A8I3P624
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9615:FN3KRP
gene id: 9615:FN3KRP
uniprot id: A0A8C0Q634
uniprot id: A0A8I3PPB5
names: Similarity
messages: Belongs to the fructosamine kinase family.

9615:PRICKLE2
gene id: 9615:PRICKLE2
uniprot id: A0A8C0N575
uniprot id: A0A8I3NE98
uniprot id: A0A8I3NK07
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9615:CYLD
gene id: 9615:CYLD
uniprot id: A0A8C0RFJ2
uniprot id: A0A8I3MLG1
uniprot id: A0A8I3MSL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9615:AZIN1
gene id: 9615:AZIN1
uniprot id: A0A8C0MTP9
uniprot id: A0A8I3MWX9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9615:BRD2
gene id: 9615:BRD2
uniprot id: Q5TJG6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis (By similarity).
messages: Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13' (By similarity).
messages: Nucleus

9615:CLDN17
gene id: 9615:CLDN17
uniprot id: A0A8C0N8B9
uniprot id: A0A8I3PAG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:POU2F2
gene id: 9615:POU2F2
uniprot id: A0A8C0M495
uniprot id: A0A8C0QFH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9615:MRPL51
gene id: 9615:MRPL51
uniprot id: A0A8C0T8Q3
uniprot id: A0A8I3Q2E1
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

9615:IFGGC1
gene id: 9615:IFGGC1
uniprot id: A0A5K1TXL6
uniprot id: A0A8C0Q9X8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9615:PSMC3IP
gene id: 9615:PSMC3IP
uniprot id: A0A8I3NBI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9615:PM20D2
gene id: 9615:PM20D2
uniprot id: A0A8C0S876
uniprot id: A0A8I3N3F7
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.

9615:STX11
gene id: 9615:STX11
uniprot id: A0A8C0MXL0
uniprot id: A0A8I3NPW6
names: Similarity
messages: Belongs to the syntaxin family.

9615:PDCD4
gene id: 9615:PDCD4
uniprot id: A0A8C0T5S2
names: Similarity
messages: Belongs to the PDCD4 family.

9615:MYH3
gene id: 9615:MYH3
uniprot id: Q076A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9615:GLO1
gene id: 9615:GLO1
uniprot id: A0A8C0TFS1
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9615:NMT1
gene id: 9615:NMT1
uniprot id: A0A8C0MIU6
uniprot id: A0A8I3NDY5
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9615:CYP2B6
gene id: 9615:CYP2B6
uniprot id: P24460
uniprot id: X5L555
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By phenobarbital.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:BCAT2
gene id: 9615:BCAT2
uniprot id: A0A8C0RJF8
uniprot id: A0A8I3MBI0
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9615:ADAMDEC1
gene id: 9615:ADAMDEC1
uniprot id: A0A8C0TDS7
uniprot id: A0A8P0NBF2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:EXT1
gene id: 9615:EXT1
uniprot id: A0A8C0SS15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.
messages: Membrane
messages: cis-Golgi network membrane

9615:CORO1A
gene id: 9615:CORO1A
uniprot id: A0A8C0PRK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

9615:CNOT2
gene id: 9615:CNOT2
uniprot id: A0A8C0QKJ3
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9615:MIP
gene id: 9615:MIP
uniprot id: A2IBY8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side (By similarity).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Fatty acylated at Met-1 and Lys-238. The acyl modifications, in decreasing order of ion abundance, are: oleoyl (C18:1) > palmitoyl (C16:0) > stearoyl (C18:0) > eicosenoyl (C20:1) > dihomo-gamma-linolenoyl (C20:3) > palmitoleoyl (C16:1) > eicosadienoyl (C20:2).
messages: Homotetramer. Homooctamer formed by head-to-head interaction between homotetramers from adjoining membranes. Interacts with CALM; one CALM molecule interacts with the cytoplasmic domains of two aquaporins, leading to channel closure. Interacts (via C-terminus) with BFSP1 (via C-terminus) in aged lens fiber cells (By similarity).
messages: Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes (By similarity).
messages: Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity).
messages: gap junction

9615:MED17
gene id: 9615:MED17
uniprot id: A0A8I3PA40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:OR10AG65
gene id: 9615:OR10AG65
uniprot id: A0A8C0YXA6
uniprot id: A0A8I3MZY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:LEO1
gene id: 9615:LEO1
uniprot id: A0A8C0TPB6
uniprot id: A0A8I3PZU5
names: Similarity
messages: Belongs to the LEO1 family.

9615:ATP6V1F
gene id: 9615:ATP6V1F
uniprot id: A0A8C0PFQ2
uniprot id: A0A8I3PF77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9615:LSM7
gene id: 9615:LSM7
uniprot id: A0A8C0MVY2
uniprot id: A0A8I3NI64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9615:NPC1L1
gene id: 9615:NPC1L1
uniprot id: A0MJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9615:KATNA1
gene id: 9615:KATNA1
uniprot id: A0A8C0N2T4
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

9615:MTHFD1
gene id: 9615:MTHFD1
uniprot id: A0A8C0QQP0
uniprot id: A0A8I3MJJ7
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9615:PURG
gene id: 9615:PURG
uniprot id: A0A8C0SRR8
uniprot id: A0A8I3S1Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9615:FAM3B
gene id: 9615:FAM3B
uniprot id: A0A8I3S7F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9615:ALDH2
gene id: 9615:ALDH2
uniprot id: A0A8I3PA71
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:VCAM1
gene id: 9615:VCAM1
uniprot id: Q28260
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
messages: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation (By similarity).
messages: Membrane

9615:HCRTR1
gene id: 9615:HCRTR1
uniprot id: A0A8I3RSX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:ATP7A
gene id: 9615:ATP7A
uniprot id: A0A8C0Z058
uniprot id: A0A8I3S4D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9615:LDB3
gene id: 9615:LDB3
uniprot id: A0A8C0S782
uniprot id: A0A8I3NFE0
uniprot id: A0A8P0NQK1
names: Subcellular Location Annotation
messages: Z line

9615:HRH2
gene id: 9615:HRH2
uniprot id: P17124
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Gastric fundus and, to a lesser extent, in brain.
messages: The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9615:NDUFV2
gene id: 9615:NDUFV2
uniprot id: A0A8C0MGU4
uniprot id: A0A8I3MKY6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9615:MTPN
gene id: 9615:MTPN
uniprot id: Q863Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myotrophin family.
messages: Cytoplasm
messages: Interacts with RELA. Interacts with the heterodimer formed by CAPZA1 and CAPZB (By similarity).
messages: Nucleus
messages: Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).
messages: perinuclear region

9615:RIMKLA
gene id: 9615:RIMKLA
uniprot id: A0A8C0RRR9
uniprot id: A0A8P0TPP9
names: Similarity
messages: Belongs to the RimK family.

9615:IPO7
gene id: 9615:IPO7
uniprot id: A0A8C0S297
uniprot id: A0A8I3NQH3
names: Subcellular Location Annotation
messages: Cytoplasm

9615:MVK
gene id: 9615:MVK
uniprot id: A0A8C0NYF9
uniprot id: A0A8I3PG05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm

9615:THNSL1
gene id: 9615:THNSL1
uniprot id: A0A8C0PXM0
uniprot id: A0A8I3MP47
names: Similarity
messages: Belongs to the threonine synthase family.

9615:TRAPPC2L
gene id: 9615:TRAPPC2L
uniprot id: A0A8I3MUS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9615:NDUFC2
gene id: 9615:NDUFC2
uniprot id: A0A8C0RQT3
uniprot id: A0A8I3N5Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9615:LOC490770
gene id: 9615:LOC490770
uniprot id: A0A8I3NEL1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9615:PHTF2
gene id: 9615:PHTF2
uniprot id: A0A8C0N6I7
uniprot id: A0A8I3PUC6
names: Subcellular Location Annotation
messages: Membrane

9615:TMCO3
gene id: 9615:TMCO3
uniprot id: A0A8C0P4N7
uniprot id: A0A8C0YV17
uniprot id: A0A8I3QCA8
names: Subcellular Location Annotation
messages: Membrane

9615:MARS2
gene id: 9615:MARS2
uniprot id: A0A8C0TCP3
uniprot id: A0A8I3PY30
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:BLOC1S5
gene id: 9615:BLOC1S5
uniprot id: A0A8C0N2S7
uniprot id: A0A8C0SNH0
uniprot id: A0A8P0NVZ7
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

9615:FAM136A
gene id: 9615:FAM136A
uniprot id: A0A8C0NYZ0
uniprot id: A0A8I3S6G4
names: Similarity
messages: Belongs to the FAM136 family.

9615:PHKG1
gene id: 9615:PHKG1
uniprot id: A0A8I3NIQ9
uniprot id: A0A8I3NKT2
names: Subunit
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9615:PHPT1
gene id: 9615:PHPT1
uniprot id: A0A8C0SLX4
uniprot id: A0A8I3MSR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the janus family.
messages: Cytoplasm
messages: Exhibits phosphohistidine phosphatase activity.
messages: Monomer.

9615:CFL2
gene id: 9615:CFL2
uniprot id: A0A8C0MJA4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9615:CTC1
gene id: 9615:CTC1
uniprot id: A0A8C0LZW7
uniprot id: A0A8I3QGR3
uniprot id: A0A8I3QH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9615:AHCYL1
gene id: 9615:AHCYL1
uniprot id: A0A8I3MFS0
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9615:SIN3B
gene id: 9615:SIN3B
uniprot id: A0A8C0STH5
uniprot id: A0A8I3Q6Z7
names: Subcellular Location Annotation
messages: Nucleus

9615:FAM160A2
gene id: 9615:FAM160A2
uniprot id: A0A8C0MYF0
uniprot id: A0A8I3MTX3
names: Similarity
messages: Belongs to the FHIP family.

9615:CNTFR
gene id: 9615:CNTFR
uniprot id: Q71DR4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).
messages: Cell membrane
messages: Expressed in retina, brain, spleen, lung, liver and kidney. In the retina it is highly expressed by photoreceptors, but also found in the RPE, inner nuclear layer and ganglion cells.
messages: Forms a heterotrimer with LIFR and IL6ST. Interacts with heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Either alone or in complex with the heterodimer CLCF1-CRLF1 interacts with SORL1; this interaction may promote internalization and lysosomal degradation.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

9615:CREBL2
gene id: 9615:CREBL2
uniprot id: A0A8C0NNU8
uniprot id: A0A8I3PKN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9615:RHOT1
gene id: 9615:RHOT1
uniprot id: A0A8C0NAB6
uniprot id: A0A8C0NDQ9
uniprot id: A0A8C0NFZ8
uniprot id: A0A8C0RKH2
uniprot id: A0A8I3NRK8
uniprot id: A0A8I3RXF7
uniprot id: A0A8I3RZR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9615:LRP1
gene id: 9615:LRP1
uniprot id: A0A8C0MZ75
uniprot id: A0A8P0S657
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ARMT1
gene id: 9615:ARMT1
uniprot id: A0A8C0SV58
uniprot id: A0A8I3MER2
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9615:TAS2R3
gene id: 9615:TAS2R3
uniprot id: A0A8C0QB49
uniprot id: Q2ABD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:CYC1
gene id: 9615:CYC1
uniprot id: A0A8C0RTK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:MYH1
gene id: 9615:MYH1
uniprot id: Q076A6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9615:ASL
gene id: 9615:ASL
uniprot id: A0A8C0LRZ5
uniprot id: A0A8I3NQ62
uniprot id: A0A8I3S060
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

9615:JPH3
gene id: 9615:JPH3
uniprot id: A0A8C0SG19
uniprot id: A0A8I3MRG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9615:SMIM12
gene id: 9615:SMIM12
uniprot id: E2R5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM12 family.
messages: Membrane

9615:UCKL1
gene id: 9615:UCKL1
uniprot id: A0A8C0P9J1
uniprot id: A0A8I3PCE6
uniprot id: A0A8I3S1L5
uniprot id: A0A8P0SHX4
names: Similarity
messages: Belongs to the uridine kinase family.

9615:GABARAP
gene id: 9615:GABARAP
uniprot id: A0A8C0N0M8
uniprot id: A0A8I3P766
names: Similarity
messages: Belongs to the ATG8 family.

9615:KRT88
gene id: 9615:KRT88
uniprot id: A0A8I3PTR1
names: Similarity
messages: Belongs to the intermediate filament family.

9615:PDIA3
gene id: 9615:PDIA3
uniprot id: A0A8C0NPX9
uniprot id: A0A8I3S5M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9615:PHACTR3
gene id: 9615:PHACTR3
uniprot id: A0A8C0TA75
uniprot id: A0A8I3NU15
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9615:LOC476445
gene id: 9615:LOC476445
uniprot id: A0A8C0SK98
uniprot id: E2QTH3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9615:CCDC65
gene id: 9615:CCDC65
uniprot id: A0A8C0P9G0
uniprot id: A0A8I3PVD3
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: flagellum axoneme

9615:MAP4K3
gene id: 9615:MAP4K3
uniprot id: A0A8C0MST1
uniprot id: A0A8I3PP22
uniprot id: A0A8P0SY61
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9615:TBXT
gene id: 9615:TBXT
uniprot id: Q9GL27
names: Function
names: Polymorphism
names: Subcellular Location Annotation
names: Subunit
messages: A mutation in position 63 is responsible for a short-tail trait in a bob-tailed dog (PubMed:11252170). The homozygous mutation is lethal (PubMed:11252170).
messages: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
messages: Monomer. Binds DNA as a monomer.
messages: Nucleus

9615:GH1
gene id: 9615:GH1
uniprot id: A0A0M6L0Q5
uniprot id: P33711
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9615:CDC42EP5
gene id: 9615:CDC42EP5
uniprot id: A0A8C0RAU8
uniprot id: A0A8I3MKB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9615:LOC479912
gene id: 9615:LOC479912
uniprot id: A0A8C0NCC1
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9615:PPP2R2B
gene id: 9615:PPP2R2B
uniprot id: A0A8C0MBY1
uniprot id: A0A8C0MCT4
uniprot id: A0A8C0QDJ1
uniprot id: A0A8C0QDX4
uniprot id: A0A8C0QIB6
uniprot id: A0A8C0QJS9
uniprot id: A0A8C0QKS4
uniprot id: A0A8I3PE40
uniprot id: A0A8I3PIK7
uniprot id: A0A8I3PLH0
uniprot id: A0A8I3PLN4
uniprot id: A0A8I3PN99
uniprot id: A0A8I3S3G0
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9615:ZNF202
gene id: 9615:ZNF202
uniprot id: A0A8I3NM31
names: Subcellular Location Annotation
messages: Nucleus

9615:GGT7
gene id: 9615:GGT7
uniprot id: A0A8C0QCL0
uniprot id: A0A8I3P300
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9615:GRIN1
gene id: 9615:GRIN1
uniprot id: Q5R1P0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
messages: Cell membrane
messages: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.
messages: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN2A or GRIN2B and GRIN3B (By similarity). Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB (By similarity). Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Found in a complex with DLG4 and PRR7 (By similarity). Found in a complex with GRIN2B and PRR7 (By similarity). Interacts with PRR7; the interaction is reduced following NMDA receptor activity (By similarity).
messages: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-918 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity).
messages: Postsynaptic cell membrane
messages: Postsynaptic density

9615:OCLN
gene id: 9615:OCLN
uniprot id: Q28269
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Dephosphorylated by PTPRJ (By similarity). Less-phosphorylated forms are found in basolateral membrane, cytosol and tight junction. More-heavily phosphorylated forms are concentrated exclusively in tight junction.
messages: Interacts with TJP1/ZO1. Interacts with VAPA. Interacts with CLDN1, CLDN6, CLDN9, CLDN11, CLDN12 and CLDN17. Interacts with PLSCR1. Interacts with LSR, ILDR1 and ILDR2.
messages: Localized at tight junctions of both epithelial and endothelial cells.
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with ZO-1.
messages: The C-terminal is cytoplasmic and is important for interaction with ZO-1. Necessary for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity).
messages: tight junction

9615:MB
gene id: 9615:MB
uniprot id: A0A1K0GV43
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9615:VPS4A
gene id: 9615:VPS4A
uniprot id: A0A8C0S3G1
uniprot id: A0A8I3N2G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9615:SNX14
gene id: 9615:SNX14
uniprot id: A0A8I3NQ11
names: Similarity
messages: Belongs to the sorting nexin family.

9615:LOC475405
gene id: 9615:LOC475405
uniprot id: A0A8C0MC76
uniprot id: A0A8I3SAM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9615:SNTB1
gene id: 9615:SNTB1
uniprot id: A0A8C0SBM6
uniprot id: A0A8I3N923
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9615:PDPN
gene id: 9615:PDPN
uniprot id: Q95152
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the podoplanin family.
messages: Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. Disialylated at Thr-59; sialic acid is critical for platelet-aggregating activity and for CLEC1B interaction.
messages: Homodimer. Interacts with CLEC1B; the interaction is independent of CLEC1B glycosylation and activates CLEC1B; the interaction is dependent of sialic acid on O-glycans. Interacts with CD9; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Interacts with LGALS8; the interaction is glycosylation-dependent; may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix. Interacts with HSPA9. Interacts (via extracellular domain) with CD44; this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration. Interacts (via cytoplasmic domain) with MSN and EZR; activates RHOA and promotes epithelial-mesenchymal transition. Interacts with CCL21; relocalized PDPN to the basolateral membrane.
messages: Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness. Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (By similarity). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix. In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (By similarity). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (By simi…
messages: Membrane
messages: Membrane raft
messages: The N-terminus is blocked.
messages: The cytoplasmic domain controls FRC elongation but is dispensable for contraction (By similarity). The cytoplasmic domain is essential for recruitment to invadopodia and ECM degradation (By similarity).
messages: filopodium membrane
messages: invadopodium
messages: lamellipodium membrane
messages: microvillus membrane
messages: ruffle membrane

9615:UBE3A
gene id: 9615:UBE3A
uniprot id: A0A8C0Q5L4
uniprot id: A0A8C0QCK5
uniprot id: A0A8P0NC72
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9615:MEN1
gene id: 9615:MEN1
uniprot id: A2SXS5
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MLL-HCF complex, at least composed of KMT2A/MLL1, MEN1, ASH2L, RBBP5, DPY30, WDR5, HCFC1 and HCFC2 (By similarity). Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4, MEN1, ASH2L, RBBP5, DPY30 and WDR5 (By similarity). Interacts with POLR2B (By similarity). Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms (By similarity). Interacts with FANCD2 and DBF4 (By similarity). Interacts with SMAD3, but not with SMAD2, nor SMAD4 (By similarity). Directly interacts with NFKB1, NFKB2 and RELA (By similarity). Interacts with JUND (via MBM motif); inhibits the interaction of JUND with MAPK10 and the phosphorylation of JUND by MAP kinases MAPK8 and MAPK10 (By similarity). Interacts with KMT2A (via MBM motif) (By similarity). The KMT2A-MEN1 complex interacts with PSIP1 with a greater affinity as MEN1 enhances interaction of KMT2A with PSIP1 (By similarity).
messages: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair (By similarity).
messages: Gene prediction.
messages: Nucleus

9615:CA8
gene id: 9615:CA8
uniprot id: A0A8C0NJY2
uniprot id: A0A8I3Q3R1
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9615:DYDC1
gene id: 9615:DYDC1
uniprot id: A0A8C0M259
uniprot id: A0A8I3NR45
names: Similarity
messages: Belongs to the dpy-30 family.

9615:CHMP4B
gene id: 9615:CHMP4B
uniprot id: A0A8C0QE10
uniprot id: A0A8I3PLN8
names: Similarity
messages: Belongs to the SNF7 family.

9615:KCNJ3
gene id: 9615:KCNJ3
uniprot id: A0A8C0SF56
uniprot id: A0A8I3PT84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9615:MRPL11
gene id: 9615:MRPL11
uniprot id: A0A8C0NPB5
uniprot id: A0A8I3NQ30
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9615:NPPA
gene id: 9615:NPPA
uniprot id: P07499
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Cleavage by MME initiates degradation of the factor and thereby regulates its activity. Degradation by IDE results in reduced activation of NPR1 (in vitro). During IDE degradation, the resulting products can temporarily stimulate NPR2 to produce cGMP, before the fragments are completely degraded and inactivated by IDE (in vitro).
messages: Degraded by IDE.
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.
messages: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (By similarity). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (By similarity). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity).
messages: May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity).
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Perikaryon
messages: Phosphorylation on Ser-127 decreases vasorelaxant activity.
messages: Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, a heterologous and in vivo expression study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).
messages: Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, an in vivo study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).
messages: Secreted
messages: The precursor molecule is proteolytically cleaved by CORIN at Arg-121 to produce the atrial natriuretic peptide (By similarity). Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide (By similarity). Additional processing gives rise to the auriculin and atriopeptin peptides (By similarity). In the kidneys, alternative processing by an unknown protease results in the peptide urodilatin (By similarity).

9615:TMED2
gene id: 9615:TMED2
uniprot id: A0A8C0PZ68
uniprot id: A0A8I3P2C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9615:DRD5
gene id: 9615:DRD5
uniprot id: A0A8I3MUP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:PPA2
gene id: 9615:PPA2
uniprot id: A0A8I3PUL1
names: Similarity
messages: Belongs to the PPase family.

9615:GDAP2
gene id: 9615:GDAP2
uniprot id: A0A8C0SIC4
uniprot id: A0A8I3NCQ2
names: Similarity
messages: Belongs to the GDAP2 family.

9615:FAM162A
gene id: 9615:FAM162A
uniprot id: A0A8C0Z4J8
uniprot id: A0A8I3PIY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9615:CPA4
gene id: 9615:CPA4
uniprot id: A0A8C0PH37
uniprot id: A0A8I3NVV4
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:KLRK1
gene id: 9615:KLRK1
uniprot id: A0A8C0NXD8
uniprot id: A0A8I3PNL2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:ENO3
gene id: 9615:ENO3
uniprot id: A0A8C0PRY5
uniprot id: A0A8I3MKD5
uniprot id: A0A8I3N5K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9615:SLC25A27
gene id: 9615:SLC25A27
uniprot id: S6C5C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:PPIL3
gene id: 9615:PPIL3
uniprot id: A0A8C0TCG0
uniprot id: A0A8I3Q7S3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9615:CDKN3
gene id: 9615:CDKN3
uniprot id: A0A8C0PP29
uniprot id: A0A8I3MUR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9615:RXRA
gene id: 9615:RXRA
uniprot id: A0A8P0NVU1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9615:STAG2
gene id: 9615:STAG2
uniprot id: A0A8C0T340
uniprot id: A0A8I3S9P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9615:GRPR
gene id: 9615:GRPR
uniprot id: A0A8C0SJC7
uniprot id: A0A8I3Q5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:YWHAE
gene id: 9615:YWHAE
uniprot id: A0A8C0PTA0
uniprot id: A0A8I3NMG3
names: Similarity
messages: Belongs to the 14-3-3 family.

9615:LOC106558049
gene id: 9615:LOC106558049
uniprot id: A0A8C0PU31
uniprot id: A0A8I3Q6B9
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9615:FSHB
gene id: 9615:FSHB
uniprot id: A0A8C0QEM9
uniprot id: E2RJZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9615:HOXD10
gene id: 9615:HOXD10
uniprot id: A0A8C0SWX2
uniprot id: A0A8I3P3F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9615:IL17A
gene id: 9615:IL17A
uniprot id: A0A8C0QCB7
uniprot id: C6L8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9615:XRCC6
gene id: 9615:XRCC6
uniprot id: A0A8C0Z0A0
uniprot id: E2RRK6
names: Subcellular Location Annotation
messages: Nucleus

9615:MMS19
gene id: 9615:MMS19
uniprot id: A0A8C0TUL3
uniprot id: A0A8I3Q0Q0
uniprot id: A0A8P0NBB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9615:SIX4
gene id: 9615:SIX4
uniprot id: A0A8C0QBK0
uniprot id: A0A8P0SJX1
names: Subcellular Location Annotation
messages: Nucleus

9615:ARL17A
gene id: 9615:ARL17A
uniprot id: A0A8C0SAH7
uniprot id: A0A8I3PN02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9615:SERINC3
gene id: 9615:SERINC3
uniprot id: A0A8C0TP27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9615:PKP1
gene id: 9615:PKP1
uniprot id: A0A8I3S0K7
names: Similarity
messages: Belongs to the beta-catenin family.

9615:UBE4B
gene id: 9615:UBE4B
uniprot id: A0A8C0RF76
uniprot id: A0A8P0TUV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9615:CRB3
gene id: 9615:CRB3
uniprot id: A0A5F4BST2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Component of a complex composed of CRB3, PALS1 and PATJ (PubMed:12527193). Interacts (via C-terminus) with PALS1 (via PDZ domain) (By similarity). Interacts with PARD6A (By similarity). Interacts (via intracellular domain) with EPB41L5 (By similarity).
messages: Involved in the establishment of cell polarity in mammalian epithelial cells (By similarity). Regulates the morphogenesis of tight junctions (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).
messages: The PDZ-binding motif is involved in the interactions with PARD6A and PALS1.
messages: tight junction

9615:TIMM22
gene id: 9615:TIMM22
uniprot id: A0A8C0PSV5
uniprot id: A0A8P0NNM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9615:PRKAR2A
gene id: 9615:PRKAR2A
uniprot id: A0A8P0TIN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9615:KATNAL2
gene id: 9615:KATNAL2
uniprot id: A0A8C0Q028
uniprot id: A0A8I3MLB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

9615:TM4SF18
gene id: 9615:TM4SF18
uniprot id: A0A8C0MTH8
uniprot id: A0A8I3PZA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9615:OR52B2
gene id: 9615:OR52B2
uniprot id: E2R1F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:DUS3L
gene id: 9615:DUS3L
uniprot id: A0A8C0P647
uniprot id: A0A8I3NLU0
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

9615:RANBP10
gene id: 9615:RANBP10
uniprot id: A0A8C0P0U7
uniprot id: A0A8I3N3U3
names: Similarity
messages: Belongs to the RANBP9/10 family.

9615:REEP2
gene id: 9615:REEP2
uniprot id: A0A8C0M646
uniprot id: A0A8P0N4G8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:OR13C1
gene id: 9615:OR13C1
uniprot id: A0A8P0SUL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:THRB
gene id: 9615:THRB
uniprot id: A0A8C0RRJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:GNRH1
gene id: 9615:GNRH1
uniprot id: A0A8C0Z370
uniprot id: A0A8I3RXY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

9615:NCAN
gene id: 9615:NCAN
uniprot id: A0A8C0TB15
uniprot id: A0A8I3NV37
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:FOXN4
gene id: 9615:FOXN4
uniprot id: A0A8I3PJW1
names: Subcellular Location Annotation
messages: Nucleus

9615:NEUROD6
gene id: 9615:NEUROD6
uniprot id: A0A8C0RFZ1
uniprot id: A0A8I3S2E3
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9615:FAM98A
gene id: 9615:FAM98A
uniprot id: A0A8C0Z5D4
uniprot id: A0A8I3S0W1
names: Similarity
messages: Belongs to the FAM98 family.

9615:SH3BGRL3
gene id: 9615:SH3BGRL3
uniprot id: A0A8C0Q229
uniprot id: A0A8I3NJI4
names: Similarity
messages: Belongs to the SH3BGR family.

9615:UCHL5
gene id: 9615:UCHL5
uniprot id: A0A8C0SA87
uniprot id: A0A8I3Q6X9
names: Similarity
messages: Belongs to the peptidase C12 family.

9615:CBY2
gene id: 9615:CBY2
uniprot id: A0A8C0SRS8
uniprot id: A0A8I3N9E7
names: Similarity
names: Subunit
messages: Belongs to the chibby family. SPERT subfamily.
messages: Homodimer. Binds to NEK1.

9615:SLC25A1
gene id: 9615:SLC25A1
uniprot id: A0A8C0P467
uniprot id: A0A8I3Q9J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:MED19
gene id: 9615:MED19
uniprot id: A0A8C0SJ30
uniprot id: A0A8I3PBY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:GRID2
gene id: 9615:GRID2
uniprot id: A0A8C0T6Y7
uniprot id: A0A8I3PCC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9615:LCN8
gene id: 9615:LCN8
uniprot id: A0A8C0M8W2
uniprot id: A0A8C0SP07
uniprot id: A0A8C0SQR2
uniprot id: A0A8I3MWP0
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:PPP6R1
gene id: 9615:PPP6R1
uniprot id: A0A8I3RRF7
names: Similarity
messages: Belongs to the SAPS family.

9615:OR6F1
gene id: 9615:OR6F1
uniprot id: A0A8C0RXZ6
uniprot id: A0A8I3N611
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:LYZF2
gene id: 9615:LYZF2
uniprot id: A0A077S9R2
uniprot id: A0A8C0P8H7
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9615:AKAP8
gene id: 9615:AKAP8
uniprot id: Q5VK71
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity).
messages: Belongs to the AKAP95 family.
messages: Binds to dimeric RII-alpha regulatory subunit of PKA during mitosis. Interacts (via C-terminus) with FIGN. Interacts with CCND3 (PubMed:14641107). Interacts with NCAPD2, CCND1, MCM2, RPS6KA1, PDE4A, CASP3, DDX5, CCNE1. Interacts with NFKB1; detetcted in the cytoplasm. Interacts with MYCBP; MYCBP is translocated to the nucleus and the interaction prevents the association of the PKA catalytic subunit leading to suppression of PKA activity. Interacts with DPY30; mediating AKAP8 association with at least the MLL4/WBP7 HMT complex. Interacts with HDAC3; increased during mitosis. Interacts with GJA1; in the nucleus and in the nuclear membrane; the nuclear association increases with progress of cell cycle G1, S and G2 phase and decreases in M phase (By similarity).
messages: Cytoplasm
messages: Nucleus matrix
messages: Phosphorylated on tyrosine residues probably by SRC subfamily protein kinases; multiple phosphorylation is leading to dissociation from nuclear structures implicated in chromatin structural changes.
messages: nucleolus

9615:ITGA2B
gene id: 9615:ITGA2B
uniprot id: Q9TUN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:FGF17
gene id: 9615:FGF17
uniprot id: A0A8P0SEN5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:NOC2L
gene id: 9615:NOC2L
uniprot id: A0A8C0RVQ9
uniprot id: A0A8P0SNL0
names: Similarity
messages: Belongs to the NOC2 family.

9615:LOC100856533
gene id: 9615:LOC100856533
uniprot id: A0A8C0PG31
uniprot id: A0A8I3PRI6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9615:ADHFE1
gene id: 9615:ADHFE1
uniprot id: A0A8C0RJC4
uniprot id: A0A8I3S0X1
uniprot id: A0A8P0TRG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9615:CXCR5
gene id: 9615:CXCR5
uniprot id: A0A8C0MC57
uniprot id: A0A8I3MGQ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:PMAIP1
gene id: 9615:PMAIP1
uniprot id: Q1PCT2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMAIP1 family.
messages: Interacts with MCL1 (By similarity). Interacts with BCL2A1 (By similarity). Interacts with BAX (By similarity). Interacts with BCL2L10 (By similarity).
messages: Mitochondrion
messages: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity).
messages: The BH3 motif is essential for pro-apoptotic activity.

9615:S100A8
gene id: 9615:S100A8
uniprot id: A0A8C0PA04
uniprot id: C0LQL0
names: Similarity
messages: Belongs to the S-100 family.

9615:HDAC8
gene id: 9615:HDAC8
uniprot id: A0A8I3P9X1
uniprot id: A0A8P0SUT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Nucleus

9615:TFF1
gene id: 9615:TFF1
uniprot id: Q863T4
names: Function
names: Subcellular Location Annotation
messages: Secreted
messages: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.

9615:GTPBP10
gene id: 9615:GTPBP10
uniprot id: A0A8I3RWN0
uniprot id: A0A8P0TG95
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9615:CCDC93
gene id: 9615:CCDC93
uniprot id: A0A8C0QF65
uniprot id: A0A8C0QI28
uniprot id: A0A8P0SAI6
uniprot id: A0A8P0TS40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC93 family.
messages: Early endosome

9615:SLC39A1
gene id: 9615:SLC39A1
uniprot id: A0A8C0P1C3
uniprot id: A0A8I3P500
names: Subcellular Location Annotation
messages: Membrane

9615:GUCY1B1
gene id: 9615:GUCY1B1
uniprot id: Q4ZHR9
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by nitric oxide in the presence of magnesium or manganese ions.
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer. Heme is required for responding to nitric oxide, but not for catalytic activity.
messages: Cytoplasm
messages: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
messages: The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1A1. Can also form inactive homodimers in vitro.
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

9615:PADI4
gene id: 9615:PADI4
uniprot id: A0A8I3MWP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9615:CTSE
gene id: 9615:CTSE
uniprot id: A0A8C0MNS6
uniprot id: A0A8C0T3R3
uniprot id: A0A8I3PVL6
uniprot id: A0A8I3SB35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Homodimer; disulfide-linked.
messages: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

9615:IFNG
gene id: 9615:IFNG
uniprot id: B6E117
uniprot id: P42161
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Released primarily from activated T lymphocytes.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9615:GUCY1A1
gene id: 9615:GUCY1A1
uniprot id: Q4ZHS0
names: Activity Regulation
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by nitric oxide in the presence of magnesium or manganese ions.
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm
messages: Has also activity with Mn(2+) (in vitro).
messages: The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1B1.
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

9615:ABHD2
gene id: 9615:ABHD2
uniprot id: A0A8C0PRF3
uniprot id: A0A8I3MLA4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9615:COX10
gene id: 9615:COX10
uniprot id: A0A8C0TB64
uniprot id: A0A8I3MWL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

9615:PHF10
gene id: 9615:PHF10
uniprot id: A0A8C0SAD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

9615:TRAM1
gene id: 9615:TRAM1
uniprot id: Q01685
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SEC61B. May interact with Derlin-1/DERL1.
messages: Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed:1315422). Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (By similarity).
messages: N-glycosylated.

9615:FAM76A
gene id: 9615:FAM76A
uniprot id: A0A8C0Q2Q9
uniprot id: A0A8I3NJ36
names: Similarity
messages: Belongs to the FAM76 family.

9615:HMCES
gene id: 9615:HMCES
uniprot id: A0A8C0N7N7
uniprot id: A0A8I3PAC0
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9615:LMLN
gene id: 9615:LMLN
uniprot id: A0A8P0NEW0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

9615:POT1
gene id: 9615:POT1
uniprot id: A0A8C0S2R4
uniprot id: A0A8I3N0G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9615:FAM168A
gene id: 9615:FAM168A
uniprot id: A0A8I3N4Q8
names: Similarity
messages: Belongs to the FAM168 family.

9615:ATP2A3
gene id: 9615:ATP2A3
uniprot id: A0A8C0RZB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9615:ZC3H15
gene id: 9615:ZC3H15
uniprot id: A0A8C0S1L3
uniprot id: A0A8I3S2Q9
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9615:CNN3
gene id: 9615:CNN3
uniprot id: A0A8P0SP42
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9615:GPAT3
gene id: 9615:GPAT3
uniprot id: A0A8C0N303
uniprot id: A0A8I3PI70
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9615:KRTCAP3
gene id: 9615:KRTCAP3
uniprot id: A0A8C0S8M7
uniprot id: A0A8P0SAF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9615:IL12B
gene id: 9615:IL12B
uniprot id: Q28268
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Secreted

9615:TCN2
gene id: 9615:TCN2
uniprot id: A0A8C0RQ11
uniprot id: A0A8I3PAV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9615:CHCHD4
gene id: 9615:CHCHD4
uniprot id: A0A8C0SXW5
uniprot id: A0A8I3PQ51
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9615:MTERF1
gene id: 9615:MTERF1
uniprot id: A0A8C0MY51
uniprot id: A0A8C0SW36
uniprot id: A0A8I3NK74
uniprot id: A0A8P0S831
names: Similarity
messages: Belongs to the mTERF family.

9615:IFNGR1
gene id: 9615:IFNGR1
uniprot id: A0A8C0M1P1
uniprot id: A0A8I3MY73
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9615:TIGD2
gene id: 9615:TIGD2
uniprot id: A0A8C0PV81
uniprot id: A0A8I3NYE6
names: Subcellular Location Annotation
messages: Nucleus

9615:GPR107
gene id: 9615:GPR107
uniprot id: A0A8C0MRV7
uniprot id: A0A8C0QAX1
uniprot id: A0A8I3PMU7
uniprot id: A0A8I3PPL9
names: Subcellular Location Annotation
messages: Membrane

9615:RFC2
gene id: 9615:RFC2
uniprot id: A0A8C0NC65
uniprot id: A0A8C0S4R7
uniprot id: A0A8I3MFP3
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9615:MX1
gene id: 9615:MX1
uniprot id: Q9N0Y3
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By type I and type III interferons.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).
messages: ISGylated.
messages: Interferon-induced dynamin-like GTPase with antiviral activity.
messages: The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
messages: The middle domain mediates self-assembly and oligomerization.
messages: perinuclear region

9615:POP5
gene id: 9615:POP5
uniprot id: A0A8C0T896
uniprot id: A0A8I3QWJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9615:SUFU
gene id: 9615:SUFU
uniprot id: A0A8C0PCL8
uniprot id: A0A8I3PTN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9615:H2AJ
gene id: 9615:H2AJ
uniprot id: A0A8C0PY79
uniprot id: A0A8I3PGL5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:TM9SF3
gene id: 9615:TM9SF3
uniprot id: A0A8C0Z6H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9615:TAC1
gene id: 9615:TAC1
uniprot id: A0A8P0S808
uniprot id: A0A8P0S827
uniprot id: A0A8P0T7M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9615:SLC2A1
gene id: 9615:SLC2A1
uniprot id: A0A8C0QL50
uniprot id: A0A8I3NRK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Membrane
messages: Photoreceptor inner segment

9615:CDC5L
gene id: 9615:CDC5L
uniprot id: A0A8C0YW82
uniprot id: A0A8I3NKY0
names: Similarity
messages: Belongs to the CEF1 family.

9615:GJB5
gene id: 9615:GJB5
uniprot id: A0A654ICX7
uniprot id: A0A8C0NSE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:PPME1
gene id: 9615:PPME1
uniprot id: A0A8P0SB29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

9615:IL2RA
gene id: 9615:IL2RA
uniprot id: A0A8C0PWX0
uniprot id: D0VYJ2
uniprot id: D2XMM7
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9615:PLPPR1
gene id: 9615:PLPPR1
uniprot id: A0A8C0QIL3
uniprot id: A0A8I3NA99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

9615:ABLIM3
gene id: 9615:ABLIM3
uniprot id: A0A8C0LV23
uniprot id: A0A8C0LYQ9
uniprot id: A0A8C0M1T9
uniprot id: A0A8I3NG08
names: Subcellular Location Annotation
messages: Cytoplasm

9615:TIPIN
gene id: 9615:TIPIN
uniprot id: A0A8C0NK10
uniprot id: A0A8I3S1C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9615:CMPK1
gene id: 9615:CMPK1
uniprot id: A0A8C0RQJ3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9615:CORO1C
gene id: 9615:CORO1C
uniprot id: A0A8I3PZZ4
names: Similarity
messages: Belongs to the WD repeat coronin family.

9615:TAF9B
gene id: 9615:TAF9B
uniprot id: A0A8C0Z0L8
uniprot id: A0A8I3P616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9615:CCND2
gene id: 9615:CCND2
uniprot id: A0A8I3SCS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9615:KPNA5
gene id: 9615:KPNA5
uniprot id: A0A8C0PXI3
uniprot id: A0A8I3MUE3
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9615:C17H2orf68
gene id: 9615:C17H2orf68
uniprot id: A0A8C0Q442
uniprot id: A0A8I3NUV2
uniprot id: A0A8I3RXW4
names: Similarity
messages: Belongs to the UPF0561 family.

9615:CNDP1
gene id: 9615:CNDP1
uniprot id: A0A8C0PKI8
uniprot id: A0A8I3MIJ8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9615:CPB2
gene id: 9615:CPB2
uniprot id: A0A8C0SRM1
uniprot id: A0A8I3RUJ7
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:HOXA6
gene id: 9615:HOXA6
uniprot id: A0A8C0S4D1
uniprot id: A0A8I3RWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:TOP3A
gene id: 9615:TOP3A
uniprot id: A0A8C0LYC9
uniprot id: A0A8I3PC45
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9615:LOC102156556
gene id: 9615:LOC102156556
uniprot id: A0A8C0RVL5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9615:SPARCL1
gene id: 9615:SPARCL1
uniprot id: A0A8C0TSG0
uniprot id: A0A8C0TWR3
uniprot id: A0A8I3NXP5
uniprot id: A0A8I3RYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9615:SPAM1
gene id: 9615:SPAM1
uniprot id: A0A8C0S4J6
uniprot id: A0A8I3MQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9615:DNAAF3
gene id: 9615:DNAAF3
uniprot id: A0A8C0LRV0
uniprot id: A0A8I3MEI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF3 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.

9615:DUSP13
gene id: 9615:DUSP13
uniprot id: A0A8C0P1G6
uniprot id: A0A8I3RXJ5
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9615:CHRNB1
gene id: 9615:CHRNB1
uniprot id: A0A8C0QFR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:SLITRK3
gene id: 9615:SLITRK3
uniprot id: A0A8C0ND14
uniprot id: A0A8I3P3H2
names: Similarity
messages: Belongs to the SLITRK family.

9615:CEP57
gene id: 9615:CEP57
uniprot id: A0A8C0YZA9
uniprot id: A0A8I3P1V5
uniprot id: A0A8I3PBW8
uniprot id: A0A8I3S2Y0
names: Similarity
messages: Belongs to the translokin family.

9615:PPP3CA
gene id: 9615:PPP3CA
uniprot id: A0A8C0P395
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9615:TGFB1
gene id: 9615:TGFB1
uniprot id: P54831
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction.
messages: Homodimer; disulfide-linked. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling and the HTRA protease activity is required for this inhibition. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with CD109, DPT and ASPN. Interacts with EFEMP2. Interacts with TSKU; the interaction contributes to regulation of the hair cycle.
messages: Homodimer; disulfide-linked. Interacts with transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains TGF-beta-1 in a latent state; each latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Interacts with LTBP1; leading to regulation of TGF-beta-1 activation. Interacts with LRRC32/GARP; leading to regulation of TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Interacts with LRRC33/NRROS; leading to regulation of TGF-beta-1 activation in macrophages and microglia. Interacts (via cell attachment site) with integrins ITGAV and ITGB6 (ITGAV:ITGB6), leading to release of the active TGF-beta-1. Interacts with NREP; the interaction results in a decrease in TGFB1 autoinduction. Interacts with HSP90AB1; inhibits latent TGFB1 activation.
messages: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'. Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 ce…
messages: N-glycosylated. Deglycosylation leads to activation of Transforming growth factor beta-1 (TGF-beta-1); mechanisms triggering deglycosylation-driven activation of TGF-beta-1 are however unclear.
messages: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.
messages: Secreted
messages: The 'straitjacket' and 'arm' domains encircle the Transforming growth factor beta-1 (TGF-beta-1) monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104.
messages: The cell attachment site motif mediates binding to integrins (ITGAV:ITGB6 or ITGAV:ITGB8). The motif locates to a long loop in the arm domain called the bowtie tail. Integrin-binding stabilizes an alternative conformation of the bowtie tail. Activation by integrin requires force application by the actin cytoskeleton, which is resisted by the 'milieu molecules' (such as LTBP1, LRRC32/GARP and/or LRRC33/NRROS), resulting in distortion of the prodomain and release of the active TGF-beta-1.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
messages: extracellular matrix

9615:KCNV2
gene id: 9615:KCNV2
uniprot id: A0A8C0N9T6
uniprot id: A0A8I3MKX7
names: Subcellular Location Annotation
messages: Membrane

9615:MTF2
gene id: 9615:MTF2
uniprot id: A0A8P0NL59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9615:SERPINA7
gene id: 9615:SERPINA7
uniprot id: A0A8C0NSU8
names: Similarity
messages: Belongs to the serpin family.

9615:TLR9
gene id: 9615:TLR9
uniprot id: Q5I2M8
uniprot id: Q865B9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).
messages: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
messages: Lysosome
messages: Membrane
messages: Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (By similarity). Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with SMPDL3B (By similarity).
messages: phagosome

9615:PGD
gene id: 9615:PGD
uniprot id: A0A8C0P5E9
uniprot id: A0A8I3MQ54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9615:LGALS4
gene id: 9615:LGALS4
uniprot id: A0A8C0S7C5
uniprot id: A0A8I3RTV7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9615:TMEM54
gene id: 9615:TMEM54
uniprot id: A0A8I3MZ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9615:RTBDN
gene id: 9615:RTBDN
uniprot id: Q4TUC0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folate receptor family.
messages: Cell membrane
messages: Not N-glycosylated.
messages: Riboflavin-binding protein which might have a role in retinal flavin transport.
messages: interphotoreceptor matrix

9615:BICD2
gene id: 9615:BICD2
uniprot id: A0A8C0PQ84
uniprot id: A0A8C0RAA3
uniprot id: A0A8I3PLU4
uniprot id: A0A8I3PLZ6
names: Similarity
messages: Belongs to the BicD family.

9615:RPGR
gene id: 9615:RPGR
uniprot id: Q9N1T2
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes.
messages: Defects in RPGR are the cause of X-linked progressive retinal atrophy (XLPRA) in the Siberian husky dog. XLPRA is a naturally occurring X-linked retinopathy closely resembling X-linked retinitis pigmentosa (XLRP) in humans.
messages: Golgi apparatus
messages: Interacts with PDE6D (By similarity). Interacts with RPGRIP1 (By similarity). Interacts with RPGRIP1L (By similarity). PDE6D, RPGRIP1 and RPGRIP1L may compete for the same binding sites (By similarity). Interacts with NPM1 (By similarity). Interacts with SMC1A and SMC3 (By similarity). Interacts with CEP290 (By similarity). Interacts with WHRN (By similarity). Interacts with SPATA7 (By similarity).
messages: Isoform 1 is expressed exclusively in testis. Isoforms 2, 3 and 4 are widely expressed.
messages: Prenylated.
messages: The RCC1 repeat region mediates interactions with RPGRIP1.
messages: centrosome
messages: cilium axoneme
messages: cilium basal body
messages: flagellum axoneme

9615:COPS7A
gene id: 9615:COPS7A
uniprot id: A0A8C0TR92
uniprot id: A0A8I3PVM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9615:EDN3
gene id: 9615:EDN3
uniprot id: Q765Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides.
messages: Expressed in which included heart, lung, liver, kidney, spleen, stomach, pancreas, duodenum, colon, uterus, ovary and testis.
messages: Secreted

9615:EIF3K
gene id: 9615:EIF3K
uniprot id: A0A8C0RKG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9615:TACR3
gene id: 9615:TACR3
uniprot id: A0A8C0PPR8
uniprot id: A2BCY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:RHBDD3
gene id: 9615:RHBDD3
uniprot id: A0A8C0T5V8
uniprot id: A0A8I3Q708
names: Subcellular Location Annotation
messages: Membrane

9615:NMNAT3
gene id: 9615:NMNAT3
uniprot id: A0A8I3PTJ4
uniprot id: A0A8I3PU25
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9615:SSTR5
gene id: 9615:SSTR5
uniprot id: A0A8C0NKF6
uniprot id: A0A8I3PIX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:COMTD1
gene id: 9615:COMTD1
uniprot id: A0A8C0NR95
uniprot id: A0A8I3NR09
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9615:SLC6A11
gene id: 9615:SLC6A11
uniprot id: A0A8C0MDK3
uniprot id: A0A8I3RV00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:SLC25A12
gene id: 9615:SLC25A12
uniprot id: A0A8C0TWK1
uniprot id: A0A8C0TZ22
uniprot id: A0A8I3PZY8
uniprot id: A0A8I3Q392
uniprot id: A0A8P0SHF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:ADSL
gene id: 9615:ADSL
uniprot id: A0A8I3P3A3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

9615:CENPA
gene id: 9615:CENPA
uniprot id: A0A8I3Q063
names: Similarity
messages: Belongs to the histone H3 family.

9615:TFF3
gene id: 9615:TFF3
uniprot id: Q863B4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity).
messages: Monomer. Homodimer; disulfide-linked.
messages: extracellular matrix

9615:RRH
gene id: 9615:RRH
uniprot id: A0A8I3Q2A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9615:SEMA4C
gene id: 9615:SEMA4C
uniprot id: A0A8C0T0R4
uniprot id: A0A8I3PFL0
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CCL21
gene id: 9615:CCL21
uniprot id: A0A8C0RLG5
uniprot id: Q68AM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:ETFRF1
gene id: 9615:ETFRF1
uniprot id: A0A8C0THG3
uniprot id: A0A8I3RZQ4
names: Similarity
messages: Belongs to the complex I LYR family.

9615:IFT43
gene id: 9615:IFT43
uniprot id: A0A8C0NE90
uniprot id: A0A8I3NMQ1
names: Similarity
messages: Belongs to the IFT43 family.

9615:VIP
gene id: 9615:VIP
uniprot id: A0A8C0Z0H7
uniprot id: A0A8I3MUL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

9615:FZD6
gene id: 9615:FZD6
uniprot id: Q8WMU5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Interacts with LMBR1L.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Membrane
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).
messages: The FZ domain is involved in binding with Wnt ligands.
messages: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

9615:BYSL
gene id: 9615:BYSL
uniprot id: A0A8C0MBF4
uniprot id: A0A8I3NTP7
names: Similarity
messages: Belongs to the bystin family.

9615:DCAF11
gene id: 9615:DCAF11
uniprot id: A0A8C0N9J0
uniprot id: A0A8I3MUZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9615:S100A12
gene id: 9615:S100A12
uniprot id: A0A8C0RX73
uniprot id: A0A8I3MKN5
names: Similarity
messages: Belongs to the S-100 family.

9615:PMP22
gene id: 9615:PMP22
uniprot id: A0A8C0PNW9
uniprot id: A0A8I3MVK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

9615:NPY5R
gene id: 9615:NPY5R
uniprot id: O62729
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity).

9615:HSPA4L
gene id: 9615:HSPA4L
uniprot id: A0A8C0MP67
uniprot id: A0A8I3P2E0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9615:DMRT1
gene id: 9615:DMRT1
uniprot id: A0A8C0PVM0
uniprot id: A0A8I3MF10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9615:ENKD1
gene id: 9615:ENKD1
uniprot id: A0A8C0NUA9
uniprot id: A0A8I3MZ13
names: Subcellular Location Annotation
messages: cilium axoneme

9615:THRA
gene id: 9615:THRA
uniprot id: A0A8C0PT61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:YIPF3
gene id: 9615:YIPF3
uniprot id: A0A8C0N2S9
uniprot id: A0A8I3NBW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

9615:H1-2
gene id: 9615:H1-2
uniprot id: A0A8I3PV53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9615:FOSB
gene id: 9615:FOSB
uniprot id: Q9TUB3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Fos subfamily.
messages: Binds DNA via bZIP domain; DNA-binding is under control of cellular redox homeostasis (in vitro) (By similarity). To enable DNA binding, the bZIP domain must undergo a conformational rearrangement which requires the reduction of the interchain disulfide bond between FosB and JunD (in vitro) (By similarity). The bZIP domain is able to form homomeric oligomers via formation of interchain disulfide bonds under non-reducing conditions (in vitro) (By similarity). Under reducing conditions, the disulfide-bonded homomeric species dissociates into monomers (in vitro) (By similarity).
messages: Heterodimer; binds to DNA as heterodimer (By similarity). Component of an AP-1 transcription factor complex; composed of FOS-JUN heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with JUN, JUNB or JUND, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Interacts with the BAF multiprotein chromatin-remodeling complex subunits SMARCB1 and SMARCD1 (By similarity). Interacts with ARID1A and JUN (By similarity).
messages: Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (By similarity). Exhibits transactivation activity in vitro (By similarity). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity).
messages: Nucleus
messages: Phosphorylated.

9615:RPE
gene id: 9615:RPE
uniprot id: A0A8C0NAZ8
uniprot id: A0A8I3RZI7
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9615:BANF1
gene id: 9615:BANF1
uniprot id: A0A8C0SLN6
uniprot id: A0A8I3NSQ5
names: Subcellular Location Annotation
messages: Nucleus

9615:TLE7
gene id: 9615:TLE7
uniprot id: A0A8C0MT09
uniprot id: A0A8I3N0A9
names: Similarity
messages: Belongs to the WD repeat Groucho/TLE family.

9615:CYSLTR1
gene id: 9615:CYSLTR1
uniprot id: A0A8C0Z0K5
uniprot id: A0A8I3PED5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:SELL
gene id: 9615:SELL
uniprot id: A0A8C0RUP4
uniprot id: A0A8I3MNI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:RHPN1
gene id: 9615:RHPN1
uniprot id: A0A8I3NLJ1
names: Similarity
messages: Belongs to the RHPN family.

9615:ERO1A
gene id: 9615:ERO1A
uniprot id: A0A8P0TPZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9615:SLC35A5
gene id: 9615:SLC35A5
uniprot id: A0A8I3Q7U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9615:DCTN6
gene id: 9615:DCTN6
uniprot id: A0A8C0PC42
uniprot id: A0A8P0N922
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9615:MAP2K3
gene id: 9615:MAP2K3
uniprot id: A0A8C0RB66
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:CUL9
gene id: 9615:CUL9
uniprot id: A0A8C0N1E3
uniprot id: A0A8P0N4Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9615:H2BC8
gene id: 9615:H2BC8
uniprot id: A0A8C0P6N2
uniprot id: H9GWB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:PBX1
gene id: 9615:PBX1
uniprot id: A0A8C0P0Q2
uniprot id: A0A8I3PRG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9615:FCF1
gene id: 9615:FCF1
uniprot id: A0A8C0NZY3
uniprot id: A0A8I3NWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9615:CLNS1A
gene id: 9615:CLNS1A
uniprot id: P35521
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Component of the methylosome, a 20S complex containing at least PRMT5/SKB1, WDR77/MEP50 and CLNS1A/pICln. May mediate SNRPD1 and SNRPD3 methylation. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with LSM10 and LSM11 (By similarity).
messages: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
messages: Nucleus
messages: Was originally thought to be a chloride channel.
messages: cytoskeleton
messages: cytosol

9615:DDR2
gene id: 9615:DDR2
uniprot id: A0A8C0P482
uniprot id: A0A8C0P6E5
uniprot id: A0A8I3PPL0
uniprot id: A0A8I3PPY7
names: Subcellular Location Annotation
messages: Membrane

9615:RNF121
gene id: 9615:RNF121
uniprot id: A0A8C0TBJ6
uniprot id: A0A8I3NH59
names: Subcellular Location Annotation
messages: Membrane

9615:NXT1
gene id: 9615:NXT1
uniprot id: A0A8P0PD31
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9615:POU3F4
gene id: 9615:POU3F4
uniprot id: A0A8C0QIH8
uniprot id: A0A8I3PBR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9615:INPP1
gene id: 9615:INPP1
uniprot id: A0A8C0SLR9
uniprot id: A0A8I3PT90
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9615:CCL25
gene id: 9615:CCL25
uniprot id: Q68A93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).
messages: Secreted

9615:CS
gene id: 9615:CS
uniprot id: A0A8C0QGS7
uniprot id: A0A8I3RVM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

9615:CRYBB2
gene id: 9615:CRYBB2
uniprot id: Q2LEC2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9615:SGK1
gene id: 9615:SGK1
uniprot id: A0A8C0MBX1
uniprot id: A0A8C0Q1J9
uniprot id: A0A8C0Q1N0
uniprot id: A0A8I3MU12
uniprot id: A0A8I3RSF1
uniprot id: A0A8I3RTW6
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9615:PDE6B
gene id: 9615:PDE6B
uniprot id: P33726
names: Cofactor
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Irish setter dogs affected with rod/cone dysplasia (RCD1) contain a nonsense mutation in the gene that gives rise to a protein of 807 AA lacking 49 AA in the C-terminal.
messages: Membrane
messages: Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
messages: Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (PubMed:8387203). Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (By similarity).
messages: photoreceptor outer segment

9615:SDR9C7
gene id: 9615:SDR9C7
uniprot id: A0A8C0S451
uniprot id: A0A8I3RWP2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:RGS14
gene id: 9615:RGS14
uniprot id: A0A8I3NDZ5
names: Subcellular Location Annotation
messages: dendrite

9615:LMOD2
gene id: 9615:LMOD2
uniprot id: A0A8I3MWE9
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9615:HLCS
gene id: 9615:HLCS
uniprot id: A0A8C0PY04
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9615:ATP6V1G3
gene id: 9615:ATP6V1G3
uniprot id: A0A8C0PCR3
uniprot id: A0A8I3PWA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9615:EGFLAM
gene id: 9615:EGFLAM
uniprot id: A0A8I3RRJ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CA12
gene id: 9615:CA12
uniprot id: A0A8P0T9U5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9615:NDUFS2
gene id: 9615:NDUFS2
uniprot id: A0A8C0RNV5
uniprot id: A0A8I3Q1H1
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

9615:YIPF4
gene id: 9615:YIPF4
uniprot id: A0A8C0NKT6
uniprot id: A0A8I3RXF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9615:SLC39A13
gene id: 9615:SLC39A13
uniprot id: A0A8I3S505
names: Subcellular Location Annotation
messages: Membrane

9615:NAXE
gene id: 9615:NAXE
uniprot id: A0A8C0LZE2
uniprot id: A0A8I3RUR7
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
messages: Homodimer. Interacts with APOA1 and APOA2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

9615:FGFR1OP2
gene id: 9615:FGFR1OP2
uniprot id: A0A8C0Z3U2
uniprot id: E2QV81
names: Similarity
messages: Belongs to the SIKE family.

9615:BTD
gene id: 9615:BTD
uniprot id: A0A8C0Z037
uniprot id: A0A8I3PVK2
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9615:KRTAP8-1
gene id: 9615:KRTAP8-1
uniprot id: A0A8C0N5Q6
uniprot id: A0A8I3PD89
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9615:NGRN
gene id: 9615:NGRN
uniprot id: A0A8C0Q0Q4
uniprot id: A0A8I3MYP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9615:SUB1
gene id: 9615:SUB1
uniprot id: A0A8C0SFX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9615:GNRHR
gene id: 9615:GNRHR
uniprot id: Q9MZI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

9615:HSBP1
gene id: 9615:HSBP1
uniprot id: A0A8C0LW68
uniprot id: A0A8I3NR49
names: Similarity
messages: Belongs to the HSBP1 family.

9615:SLC37A4
gene id: 9615:SLC37A4
uniprot id: A0A8C0M9B8
uniprot id: A0A8I3MHL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9615:MTMR11
gene id: 9615:MTMR11
uniprot id: A0A8C0ME00
uniprot id: A0A8I3NKJ9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9615:STARD8
gene id: 9615:STARD8
uniprot id: A0A8I3PWZ9
uniprot id: A0A8I3QPP4
names: Subcellular Location Annotation
messages: Cytoplasm

9615:ARRDC4
gene id: 9615:ARRDC4
uniprot id: A0A8I3MEL9
names: Similarity
messages: Belongs to the arrestin family.

9615:OR7C1B
gene id: 9615:OR7C1B
uniprot id: A0A8C0PC23
uniprot id: A0A8I3PI73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:GAPVD1
gene id: 9615:GAPVD1
uniprot id: A0A8C0TCP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9615:BPNT1
gene id: 9615:BPNT1
uniprot id: A0A8C0P8L9
uniprot id: A0A8C0PBI4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9615:FGFR2
gene id: 9615:FGFR2
uniprot id: Q9TT07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:PHB2
gene id: 9615:PHB2
uniprot id: A0A8C0P996
uniprot id: A0A8I3PW80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9615:RNASEH1
gene id: 9615:RNASEH1
uniprot id: A0A8P0NNY0
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9615:PPP1R21
gene id: 9615:PPP1R21
uniprot id: A0A8I3MZ61
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9615:TBXA2R
gene id: 9615:TBXA2R
uniprot id: A0A8C0QLX5
uniprot id: A0A8I3NCM2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:LOC100683370
gene id: 9615:LOC100683370
uniprot id: A0A8C0S7Q9
uniprot id: A0A8I3PVX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9615:ADGRE1
gene id: 9615:ADGRE1
uniprot id: Q2Q422
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:COL4A5
gene id: 9615:COL4A5
uniprot id: Q28247
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A defect in COL4A5 has been found to be the cause of canine X-linked hereditary nephritis (HN), a disease similar to that in humans (also referred to as Alport syndrome) characterized by progressive renal failure and neurosensory deafness.
messages: Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
messages: Belongs to the type IV collagen family.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
messages: There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
messages: basement membrane

9615:SNCA
gene id: 9615:SNCA
uniprot id: A0A8C0PHH6
uniprot id: A0A8I3PAH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

9615:USP11
gene id: 9615:USP11
uniprot id: A0A8C0T0P0
uniprot id: A0A8I3QL54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9615:TRAPPC1
gene id: 9615:TRAPPC1
uniprot id: A0A8C0RZV3
uniprot id: A0A8I3PU34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9615:KCNK16
gene id: 9615:KCNK16
uniprot id: A0A8P0TRL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:PLAGL2
gene id: 9615:PLAGL2
uniprot id: A0A8C0RHX0
uniprot id: A0A8I3S1Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9615:CPLANE2
gene id: 9615:CPLANE2
uniprot id: A0A8C0N6T9
uniprot id: A0A8I3MTE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9615:LOC479911
gene id: 9615:LOC479911
uniprot id: A0A8C0SNF4
uniprot id: A0A8I3MJB3
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9615:IL13
gene id: 9615:IL13
uniprot id: Q9N0W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-4/IL-13 family.
messages: Cytokine that plays important roles in allergic inflammation and immune response to parasite infection. Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6. Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity).
messages: Interacts with IL13RA2.
messages: Secreted

9615:BPIFC
gene id: 9615:BPIFC
uniprot id: A0A8P0NWK3
uniprot id: A0A8P0P2N4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9615:PEX16
gene id: 9615:PEX16
uniprot id: A0A8C0T8H2
uniprot id: A0A8I3PZV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9615:SPINK4
gene id: 9615:SPINK4
uniprot id: A0A8I3P8D3
names: Subcellular Location Annotation
messages: Secreted

9615:ING5
gene id: 9615:ING5
uniprot id: A0A8C0Z6P3
uniprot id: A0A8I3PQF3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9615:SESN1
gene id: 9615:SESN1
uniprot id: A0A8C0N521
uniprot id: A0A8C0S7I6
uniprot id: A0A8I3NDQ5
uniprot id: A0A8P0P2T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9615:TOM1
gene id: 9615:TOM1
uniprot id: A0A8C0RE13
uniprot id: A0A8I3RVJ5
names: Similarity
messages: Belongs to the TOM1 family.

9615:SF1
gene id: 9615:SF1
uniprot id: A0A8C0MCV9
uniprot id: A0A8C0RD15
uniprot id: A0A8C0THZ8
uniprot id: A0A8C0Z4M0
uniprot id: A0A8I3Q776
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

9615:TCP11
gene id: 9615:TCP11
uniprot id: A0A8C0YYU7
names: Similarity
messages: Belongs to the TCP11 family.

9615:WDR1
gene id: 9615:WDR1
uniprot id: A0A5K1UTD0
names: Subcellular Location Annotation
messages: COPI-coated vesicle membrane

9615:INPP5J
gene id: 9615:INPP5J
uniprot id: A0A8C0TL98
uniprot id: A0A8I3S2X3
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9615:DIABLO
gene id: 9615:DIABLO
uniprot id: A0A8C0TW86
uniprot id: A1DZY5
names: Subcellular Location Annotation
messages: Mitochondrion

9615:IGF2R
gene id: 9615:IGF2R
uniprot id: B1H0W0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PDP2
gene id: 9615:PDP2
uniprot id: A0A8I3NTB1
names: Similarity
messages: Belongs to the PP2C family.

9615:EOMES
gene id: 9615:EOMES
uniprot id: A0A8C0T8J2
uniprot id: A0A8I3S4G5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:EPHA7
gene id: 9615:EPHA7
uniprot id: A0A8C0MGS0
names: Subcellular Location Annotation
messages: Membrane

9615:GDF2
gene id: 9615:GDF2
uniprot id: A0A8C0YWM6
uniprot id: A0A8I3N8R4
names: Similarity
messages: Belongs to the TGF-beta family.

9615:PTPRG
gene id: 9615:PTPRG
uniprot id: A0A8C0NLQ0
uniprot id: A0A8C0NYF7
uniprot id: A0A8I3NWQ4
uniprot id: A0A8I3NZJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9615:TRIAP1
gene id: 9615:TRIAP1
uniprot id: A0A8C0RS77
uniprot id: A0A8I3Q9C1
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9615:LPIN1
gene id: 9615:LPIN1
uniprot id: A0A8I3Q115
uniprot id: A0A8I3Q2F0
uniprot id: A0A8I3SBU5
names: Similarity
messages: Belongs to the lipin family.

9615:ATP5F1A
gene id: 9615:ATP5F1A
uniprot id: A0A1B1X469
uniprot id: A0A8C0QKG4
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9615:RER1
gene id: 9615:RER1
uniprot id: A0A8C0RAD3
uniprot id: A0A8I3P3J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9615:ATL1
gene id: 9615:ATL1
uniprot id: A0A8C0PWU7
uniprot id: A0A8C0PX24
uniprot id: A0A8I3RSN6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9615:CAT
gene id: 9615:CAT
uniprot id: O97492
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
messages: Homotetramer. Interacts (via microbody targeting signal) with PEX5, monomeric form interacts with PEX5, leading to its translocation into peroxisomes.
messages: Peroxisome

9615:MRPL47
gene id: 9615:MRPL47
uniprot id: A0A8C0T8R9
uniprot id: A0A8I3P056
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

9615:PDGFB
gene id: 9615:PDGFB
uniprot id: Q6Q7I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel homodimer; disulfide-linked. Antiparallel heterodimer with PDGFA; disulfide-linked. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity). Interacts with LRP1 (By similarity). Interacts with SORL1 (via the N-terminal ectodomain) (By similarity).
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).
messages: Secreted

9615:KCNB1
gene id: 9615:KCNB1
uniprot id: A0A8C0RS07
uniprot id: A0A8I3PX68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: sarcolemma
messages: synaptosome

9615:COX4I2
gene id: 9615:COX4I2
uniprot id: A0A8C0TEQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9615:ELSPBP1
gene id: 9615:ELSPBP1
uniprot id: A0A8C0Q3P2
uniprot id: A0A8I3RS02
uniprot id: Q9GL25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the seminal plasma protein family.
messages: Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity).
messages: Detected in epididymal duct epithelium, cauda epididymidal fluid and on sperm membrane (at protein level).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:CHRNB4
gene id: 9615:CHRNB4
uniprot id: A0A8C0TE45
uniprot id: A0A8I3NCE4
uniprot id: A0A8P0TEX7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:NOX5
gene id: 9615:NOX5
uniprot id: A7E3L5
names: Subcellular Location Annotation
messages: Membrane

9615:SLC25A23
gene id: 9615:SLC25A23
uniprot id: A0A8C0TNG6
uniprot id: A0A8I3N616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:C20H19orf53
gene id: 9615:C20H19orf53
uniprot id: A0A8C0T8U1
uniprot id: A0A8I3PRP3
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9615:TPI1
gene id: 9615:TPI1
uniprot id: A0A346M2B2
uniprot id: P54714
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9615:MPPE1
gene id: 9615:MPPE1
uniprot id: A0A8C0MA41
uniprot id: A0A8C0MBJ1
uniprot id: A0A8P0NJY0
uniprot id: A0A8P0NJY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9615:PARD3B
gene id: 9615:PARD3B
uniprot id: A0A8I3S0X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

9615:LHX1
gene id: 9615:LHX1
uniprot id: A0A8C0QBI9
uniprot id: A0A8I3Q2H8
names: Subcellular Location Annotation
messages: Nucleus

9615:EMC6
gene id: 9615:EMC6
uniprot id: A0A8C0MRT7
uniprot id: A0A8I3NPK2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:DUSP5
gene id: 9615:DUSP5
uniprot id: A0A8C0P5F9
uniprot id: A0A8I3Q097
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9615:AMT
gene id: 9615:AMT
uniprot id: Q9TSZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9615:CYP2D15
gene id: 9615:CYP2D15
uniprot id: Q29473
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.
messages: Liver. Also detected in several other tissues.
messages: Microsome membrane

9615:GSDME
gene id: 9615:GSDME
uniprot id: A0A8I3RXU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9615:INTS13
gene id: 9615:INTS13
uniprot id: A0A8C0TE02
uniprot id: E2R9F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

9615:PPP4R2
gene id: 9615:PPP4R2
uniprot id: A0A8C0NIR3
uniprot id: A0A8P0N8X5
names: Similarity
messages: Belongs to the PPP4R2 family.

9615:TM9SF4
gene id: 9615:TM9SF4
uniprot id: A0A8C0TMC3
uniprot id: A0A8P0TQD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9615:GLOD4
gene id: 9615:GLOD4
uniprot id: A0A8C0RVV2
uniprot id: A0A8I3NSX2
names: Similarity
messages: Belongs to the glyoxalase I family.

9615:NR2F2
gene id: 9615:NR2F2
uniprot id: A0A8C0TP54
uniprot id: A0A8I3MKR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:LOC489748
gene id: 9615:LOC489748
uniprot id: A0A8I3RZ66
names: Subcellular Location Annotation
messages: Membrane

9615:IFI6
gene id: 9615:IFI6
uniprot id: A0A8I3NGJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9615:OR1E1
gene id: 9615:OR1E1
uniprot id: P30955
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Putative odorant or sperm cell receptor.

9615:PRODH2
gene id: 9615:PRODH2
uniprot id: A0A8C0MTA1
uniprot id: A0A8P0SC17
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

9615:ORAI3
gene id: 9615:ORAI3
uniprot id: A0A8I3NYN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9615:SCUBE3
gene id: 9615:SCUBE3
uniprot id: A0A8C0SNU3
uniprot id: A0A8C0SSN2
uniprot id: A0A8C0YYW6
uniprot id: A0A8I3SBJ8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:COQ4
gene id: 9615:COQ4
uniprot id: A0A8I3Q2J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9615:NUP62
gene id: 9615:NUP62
uniprot id: A0A8C0M0Y9
uniprot id: A0A8I3P0U9
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

9615:ZBED4
gene id: 9615:ZBED4
uniprot id: A0A8C0N0S8
uniprot id: A0A8I3N4E3
names: Subcellular Location Annotation
messages: Nucleus

9615:SEZ6
gene id: 9615:SEZ6
uniprot id: A0A8P0NPZ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MYH9
gene id: 9615:MYH9
uniprot id: Q258K2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity).
messages: Cortical granule
messages: ISGylated.
messages: Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2) (By similarity). Interacts with RASIP1 (By similarity). Interacts with DDR1 (By similarity). Interacts with PDLIM2 (By similarity). Interacts with SVIL (By similarity). Interacts with HTRA3 (By similarity). Interacts with Myo7a (By similarity). Interacts with CFAP95 (By similarity). Interacts with LIMCH1; independently of the integration of MYH9 into the myosin complex (By similarity). Interacts with RAB3A (By similarity). Interacts with ZBED4 (By similarity). Interacts with S100A4; this interaction increases cell motility (By similarity).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: Ubiquitination.
messages: cell cortex
messages: cytoskeleton

9615:MOK
gene id: 9615:MOK
uniprot id: A0A8C0MBD1
uniprot id: A0A8I3MWG6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:LZTS2
gene id: 9615:LZTS2
uniprot id: A0A8C0TDW0
uniprot id: A0A8I3NZ94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

9615:GAST
gene id: 9615:GAST
uniprot id: P01353
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9615:NHEJ1
gene id: 9615:NHEJ1
uniprot id: A0A8C0TQV2
uniprot id: J9P1R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

9615:NDUFA5
gene id: 9615:NDUFA5
uniprot id: A0A8I3MYH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:RRP36
gene id: 9615:RRP36
uniprot id: A0A8C0RZM6
uniprot id: A0A8I3N308
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

9615:TRPC4
gene id: 9615:TRPC4
uniprot id: A0A8C0NNP4
uniprot id: A0A8I3PSS9
names: Subcellular Location Annotation
messages: Membrane

9615:PTPN1
gene id: 9615:PTPN1
uniprot id: A0A8C0YVM6
uniprot id: A0A8P0NN43
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9615:CYBB
gene id: 9615:CYBB
uniprot id: A0A8C0SUZ1
uniprot id: A7E3K7
names: Subcellular Location Annotation
messages: Membrane

9615:C34H3orf70
gene id: 9615:C34H3orf70
uniprot id: A0A8C0Z6U6
uniprot id: A0A8I3Q3W8
names: Similarity
messages: Belongs to the UPF0524 family.

9615:SNX1
gene id: 9615:SNX1
uniprot id: A0A8C0NWD4
uniprot id: A0A8I3PIQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9615:PKIG
gene id: 9615:PKIG
uniprot id: A0A8C0TRK8
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9615:SLC6A13
gene id: 9615:SLC6A13
uniprot id: A0A8C0RK30
uniprot id: A0A8I3Q066
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Membrane

9615:GGA3
gene id: 9615:GGA3
uniprot id: A0A8C0PXN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9615:ELOVL5
gene id: 9615:ELOVL5
uniprot id: A0A8C0NPH6
uniprot id: A0A8C0RM88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: dendrite

9615:SLC15A1
gene id: 9615:SLC15A1
uniprot id: Q8WMX5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane
messages: Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen.
messages: The extracellular domain (ECD) region specifically binds trypsin.

9615:U2AF2
gene id: 9615:U2AF2
uniprot id: A0A8C0LZ00
uniprot id: A0A8I3RP62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

9615:TET3
gene id: 9615:TET3
uniprot id: A0A8I3PD47
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9615:CRTC1
gene id: 9615:CRTC1
uniprot id: A0A8C0TGH1
uniprot id: A0A8C0TK61
uniprot id: A0A8I3P914
uniprot id: A0A8I3PJT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9615:GPR34
gene id: 9615:GPR34
uniprot id: A0A8P0PQD8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:SPAG11B
gene id: 9615:SPAG11B
uniprot id: A0A8C0MV68
uniprot id: Q30KR3
names: Subcellular Location Annotation
messages: Secreted

9615:DYNLT4
gene id: 9615:DYNLT4
uniprot id: A0A8C0T510
uniprot id: A0A8P0SA65
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9615:CYYR1
gene id: 9615:CYYR1
uniprot id: A0A8C0TGJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYYR1 family.
messages: Membrane

9615:ALOX12B
gene id: 9615:ALOX12B
uniprot id: A0A8C0P4Q0
uniprot id: A0A8I3PY71
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PGK1
gene id: 9615:PGK1
uniprot id: A0A8C0SZN8
uniprot id: A0A8I3P9Y9
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9615:TOLLIP
gene id: 9615:TOLLIP
uniprot id: A0A8C0PDP9
uniprot id: A0A8I3N9K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9615:PPT2
gene id: 9615:PPT2
uniprot id: A0A8I3NUN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Lysosome

9615:ANXA2
gene id: 9615:ANXA2
uniprot id: Q6TEQ7
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
messages: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH. Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR. Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (By similarity). Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity). Interacts with S100A4 (By similarity). May interact with UBAP2 (By similarity).
messages: ISGylated.
messages: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
messages: basement membrane

9615:PIP
gene id: 9615:PIP
uniprot id: A0A8C0RYL6
uniprot id: A0A8P0S9C3
names: Similarity
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.

9615:TAS2R1
gene id: 9615:TAS2R1
uniprot id: A0A8C0TLH4
uniprot id: Q2ABE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:SNAP25
gene id: 9615:SNAP25
uniprot id: A0A8C0QNH3
uniprot id: A0A8C0RZD7
uniprot id: A0A8I3PMC0
uniprot id: A0A8I3PWK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9615:LOC100856782
gene id: 9615:LOC100856782
uniprot id: A0A8C0SV37
uniprot id: A0A8I3S301
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9615:RRM1
gene id: 9615:RRM1
uniprot id: A0A8C0RNZ0
uniprot id: A0A8I3RYN5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9615:LOC448801
gene id: 9615:LOC448801
uniprot id: P19236
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Cytoplasm
messages: Inhibited by leupeptin and bis(5-amidino-2-benzimidazolyl)methane (BABIM).
messages: Mononuclear cells within skin, intestine, trachea and lung parenchyma, and polymorphonuclear leukocytes within capillaries and blood.
messages: N-glycosylated.
messages: Oligomer; disulfide-linked.
messages: Trypsin-like serine protease. Has a preference for extended substrates with basic residues at the P1 position; Arg is preferred over Lys. Active towards calcitonin gene-related peptide and gelatin. Not active towards substance P, vasoactive intestinal peptide, type I collagen or azocasein.

9615:PHOX2B
gene id: 9615:PHOX2B
uniprot id: A0A8C0MTP5
uniprot id: A0A8P0N4X6
names: Subcellular Location Annotation
messages: Nucleus

9615:ATXN2L
gene id: 9615:ATXN2L
uniprot id: A0A8C0LTZ1
uniprot id: A0A8C0R9B6
names: Similarity
messages: Belongs to the ataxin-2 family.

9615:ZSCAN31
gene id: 9615:ZSCAN31
uniprot id: A0A8C0S5A9
uniprot id: A0A8P0PHI8
names: Subcellular Location Annotation
messages: Nucleus

9615:HIGD1A
gene id: 9615:HIGD1A
uniprot id: A0A8C0Z033
uniprot id: A0A8I3PAZ6
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9615:LOC100686187
gene id: 9615:LOC100686187
uniprot id: A0A8I3S4Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9615:KCNQ5
gene id: 9615:KCNQ5
uniprot id: A0A8P0N5L1
uniprot id: A0A8P0ST97
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:E2F1
gene id: 9615:E2F1
uniprot id: A0A8C0Q8Y6
uniprot id: A0A8I3PK29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9615:GNG8
gene id: 9615:GNG8
uniprot id: A0A8C0PZW8
uniprot id: A0A8I3MNZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:MVP
gene id: 9615:MVP
uniprot id: A0A8C0SNT7
uniprot id: A0A8I3MGN1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9615:CRELD1
gene id: 9615:CRELD1
uniprot id: A0A8C0TPX3
uniprot id: A0A8I3N8T9
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TMPRSS4
gene id: 9615:TMPRSS4
uniprot id: A0A8P0P7E4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PLXNB1
gene id: 9615:PLXNB1
uniprot id: A0A8P0NEM9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:CAPN6
gene id: 9615:CAPN6
uniprot id: A0A8C0SR05
uniprot id: A0A8I3PJW4
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:DLA-79
gene id: 9615:DLA-79
uniprot id: Q30428
names: Similarity
messages: Belongs to the MHC class I family.

9615:OR6C1K
gene id: 9615:OR6C1K
uniprot id: A0A8C0PXC0
uniprot id: A0A8I3NGM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SERPINH1
gene id: 9615:SERPINH1
uniprot id: A0A8P0SAZ3
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

9615:ATP8B2
gene id: 9615:ATP8B2
uniprot id: A0A8C0RS62
uniprot id: A0A8I3RY77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:IFT20
gene id: 9615:IFT20
uniprot id: A0A8C0N7T2
uniprot id: A0A8I3NWB5
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9615:BCL2L1
gene id: 9615:BCL2L1
uniprot id: A0A8C0TGM4
uniprot id: Q76LT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9615:LIPT1
gene id: 9615:LIPT1
uniprot id: A0A8C0NSY5
uniprot id: A0A8I3PAB4
names: Similarity
messages: Belongs to the LplA family.

9615:SRPX
gene id: 9615:SRPX
uniprot id: A0A8I3PN65
uniprot id: A0A8I3PTH7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CLTB
gene id: 9615:CLTB
uniprot id: A0A8C0LZB0
uniprot id: A0A8C0Z0Y9
uniprot id: A0A8I3NLC1
uniprot id: A0A8I3NML2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9615:CLK3
gene id: 9615:CLK3
uniprot id: A0A8C0MX44
uniprot id: A0A8I3Q436
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:CAMTA1
gene id: 9615:CAMTA1
uniprot id: A0A8C0RFB0
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

9615:INTS9
gene id: 9615:INTS9
uniprot id: A0A8C0PFI9
uniprot id: A0A8I3PDL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

9615:FAM155B
gene id: 9615:FAM155B
uniprot id: A0A8C0TLV8
uniprot id: A0A8I3QQ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

9615:MMP19
gene id: 9615:MMP19
uniprot id: A0A8C0PZW6
uniprot id: A0A8I3MTX4
names: Similarity
messages: Belongs to the peptidase M10A family.

9615:COX17
gene id: 9615:COX17
uniprot id: Q6J3Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COX17 family.
messages: Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
messages: Cytoplasm
messages: Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure.
messages: Mitochondrion intermembrane space

9615:SLC22A8
gene id: 9615:SLC22A8
uniprot id: A0A8C0SXT3
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9615:PARP3
gene id: 9615:PARP3
uniprot id: A0A8C0RG79
uniprot id: A0A8I3P5K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9615:PIK3C3
gene id: 9615:PIK3C3
uniprot id: A0A8C0QN39
uniprot id: A0A8I3MWD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

9615:GET3
gene id: 9615:GET3
uniprot id: A0A8C0RP10
uniprot id: A0A8I3NZF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9615:TRIM54
gene id: 9615:TRIM54
uniprot id: A0A8C0S197
uniprot id: A0A8I3N499
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9615:VPS26A
gene id: 9615:VPS26A
uniprot id: A0A8C0RXA5
uniprot id: A0A8I3MQ24
uniprot id: A0A8P0NFS9
names: Similarity
messages: Belongs to the VPS26 family.

9615:PSME3IP1
gene id: 9615:PSME3IP1
uniprot id: A0A8C0YW64
uniprot id: A0A8I3MPE6
names: Subcellular Location Annotation
messages: Nucleus

9615:RXRG
gene id: 9615:RXRG
uniprot id: A0A8C0PBD5
uniprot id: A0A8C0T1Q9
uniprot id: A0A8I3PIS2
uniprot id: A0A8P0PBJ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9615:MSTO1
gene id: 9615:MSTO1
uniprot id: A0A8C0PLQ9
uniprot id: A0A8I3RYJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

9615:PTCD3
gene id: 9615:PTCD3
uniprot id: A0A8C0SXT4
uniprot id: A0A8I3RXL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9615:OR51M1
gene id: 9615:OR51M1
uniprot id: A0A8C0NK56
uniprot id: A0A8I3P609
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MTRF1
gene id: 9615:MTRF1
uniprot id: A0A8C0TE43
uniprot id: A0A8I3NN91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9615:CDNF
gene id: 9615:CDNF
uniprot id: A0A8C0NI63
uniprot id: A0A8I3P4A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9615:ZNF24
gene id: 9615:ZNF24
uniprot id: A0A8C0RB55
uniprot id: A0A8I3MZ50
names: Subcellular Location Annotation
messages: Nucleus

9615:TATDN2
gene id: 9615:TATDN2
uniprot id: A0A8I3N234
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9615:ARHGEF1
gene id: 9615:ARHGEF1
uniprot id: A0A8I3MIE5
uniprot id: A0A8I3MIZ9
uniprot id: A0A8I3RRK7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9615:JUP
gene id: 9615:JUP
uniprot id: A0A8C0P431
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
messages: Membrane
messages: adherens junction
messages: desmosome

9615:TBX6
gene id: 9615:TBX6
uniprot id: A0A8C0LX63
uniprot id: A0A8I3RRQ7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:TPRA1
gene id: 9615:TPRA1
uniprot id: A0A8I3NT58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9615:GSG1
gene id: 9615:GSG1
uniprot id: A0A8C0NFG7
uniprot id: A0A8I3PIS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9615:CPB1
gene id: 9615:CPB1
uniprot id: A0A8C0QIC0
uniprot id: A0A8I3PKA8
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:ORC4
gene id: 9615:ORC4
uniprot id: A0A8C0TGT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9615:KCNAB1
gene id: 9615:KCNAB1
uniprot id: A0A8C0NNK3
uniprot id: A0A8C0T476
uniprot id: A0A8I3PCA7
uniprot id: A0A8I3PCH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9615:TMEM230
gene id: 9615:TMEM230
uniprot id: A0A8C0P2P1
uniprot id: A0A8I3QG26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9615:FABP12
gene id: 9615:FABP12
uniprot id: A0A8C0TAR2
uniprot id: A0A8I3NVJ7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:NLRP14
gene id: 9615:NLRP14
uniprot id: A0A8P0NZX0
names: Similarity
messages: Belongs to the NLRP family.

9615:CSGALNACT2
gene id: 9615:CSGALNACT2
uniprot id: A0A8C0TUH7
uniprot id: A0A8C0TYX2
uniprot id: A0A8I3Q1Q4
uniprot id: A0A8I3Q2I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9615:PTGS1
gene id: 9615:PTGS1
uniprot id: Q8HZR1
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Brain cortex. Isoform 2 is expressed in the cerebral cortex and heart.
messages: Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
messages: Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Microsome membrane
messages: N-glycosylated. N-linked glycosylation is necessary for enzymatic activity.
messages: No enzymatic activity. Membrane-bound.
messages: PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
messages: The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.
messages: The cyclooxygenase activity is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen, flurbiprofen, ketoprofen, naproxen, flurbiprofen, anirolac, fenclofenac and diclofenac.

9615:FAM102A
gene id: 9615:FAM102A
uniprot id: A0A8C0N0S9
uniprot id: A0A8I3MZH4
names: Similarity
messages: Belongs to the FAM102 family.

9615:TGIF1
gene id: 9615:TGIF1
uniprot id: A0A8I3MRF1
names: Subcellular Location Annotation
messages: Nucleus

9615:CHRM2
gene id: 9615:CHRM2
uniprot id: A0A8I3N4M6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9615:KCNJ5
gene id: 9615:KCNJ5
uniprot id: A0A8C0MAQ1
uniprot id: A0A8P0SF79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9615:MID1
gene id: 9615:MID1
uniprot id: A0A8C0MNF0
uniprot id: A0A8I3S5W2
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

9615:UNC5A
gene id: 9615:UNC5A
uniprot id: A0A8C0MA90
uniprot id: A0A8C0SWU4
uniprot id: A0A8I3NAF5
uniprot id: A0A8I3RWP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9615:FGD6
gene id: 9615:FGD6
uniprot id: A0A8C0QFB6
uniprot id: A0A8I3PLR1
names: Subcellular Location Annotation
messages: cytoskeleton

9615:PGM1
gene id: 9615:PGM1
uniprot id: A0A8C0S5M2
uniprot id: A0A8C0S5V3
uniprot id: A0A8I3MML3
uniprot id: A0A8I3MXZ7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9615:ZNF483
gene id: 9615:ZNF483
uniprot id: A0A8P0TDK7
names: Subcellular Location Annotation
messages: Nucleus

9615:NANOS2
gene id: 9615:NANOS2
uniprot id: A0A8C0QJZ7
uniprot id: A0A8I3MLE5
names: Similarity
messages: Belongs to the nanos family.

9615:LTB4R
gene id: 9615:LTB4R
uniprot id: A0A8P0NR97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:RPL11
gene id: 9615:RPL11
uniprot id: A0A8C0PQT2
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9615:SAXO2
gene id: 9615:SAXO2
uniprot id: A0A8C0QHS4
uniprot id: A0A8I3MND2
names: Similarity
messages: Belongs to the FAM154 family.

9615:PPTC7
gene id: 9615:PPTC7
uniprot id: A0A8C0Z2Z9
uniprot id: A0A8I3Q3I9
names: Similarity
messages: Belongs to the PP2C family.

9615:NKAPL
gene id: 9615:NKAPL
uniprot id: A0A8C0S5D2
uniprot id: A0A8I3P175
names: Similarity
messages: Belongs to the NKAP family.

9615:DAZAP2
gene id: 9615:DAZAP2
uniprot id: A0A8C0PBN1
uniprot id: A0A8I3P0Q8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9615:ADAM29
gene id: 9615:ADAM29
uniprot id: A0A8C0TC12
uniprot id: A0A8I3P2J4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CD8A
gene id: 9615:CD8A
uniprot id: P33706
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked heterodimers with CD8B at the cell surface. Forms also homodimers in several cell types including NK-cells or peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.
messages: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
messages: O-glycosylated.
messages: Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.
messages: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.

9615:GTF2H5
gene id: 9615:GTF2H5
uniprot id: A0A8C0TG13
uniprot id: A0A8I3MY59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9615:SPAG7
gene id: 9615:SPAG7
uniprot id: A0A8C0Q3Z0
names: Subcellular Location Annotation
messages: Nucleus

9615:ACSL6
gene id: 9615:ACSL6
uniprot id: A0A8I3N2U1
uniprot id: A0A8I3NBT7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

9615:LRRC7
gene id: 9615:LRRC7
uniprot id: A0A8P0SZJ5
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9615:ATG5
gene id: 9615:ATG5
uniprot id: A0A8C0N3L6
uniprot id: A0A8I3RU83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9615:SLC6A18
gene id: 9615:SLC6A18
uniprot id: A0A8C0MNP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:ARCN1
gene id: 9615:ARCN1
uniprot id: A0A8C0Q393
uniprot id: A0A8I3MEN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9615:NRP1
gene id: 9615:NRP1
uniprot id: A0A8C0PU36
uniprot id: A0A8I3N3A8
uniprot id: A0A8I3N3D9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SGCG
gene id: 9615:SGCG
uniprot id: Q8SQ72
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Disulfide bonds are present.
messages: Interacts with the syntrophin SNTA1. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Interacts with FLNC (By similarity).
messages: cytoskeleton
messages: sarcolemma

9615:CTU2
gene id: 9615:CTU2
uniprot id: A0A8C0NP19
uniprot id: A0A8I3RSU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTU2/NCS2 family.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9615:LOC106560171
gene id: 9615:LOC106560171
uniprot id: A0A8C0RGA8
uniprot id: A0A8I3NGA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Endoplasmic reticulum

9615:KDR
gene id: 9615:KDR
uniprot id: A0A8C0NTB4
uniprot id: Q2XPT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:GDA
gene id: 9615:GDA
uniprot id: A0A8C0PUH1
uniprot id: A0A8I3RQL8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9615:C7H1orf74
gene id: 9615:C7H1orf74
uniprot id: A0A8C0NM71
uniprot id: A0A8I3MGH7
uniprot id: A0A8I3RQZ9
names: Similarity
messages: Belongs to the UPF0739 family.

9615:SEMA6A
gene id: 9615:SEMA6A
uniprot id: A0A8C0PJ87
uniprot id: A0A8C0SHS0
uniprot id: A0A8C0YXF1
uniprot id: A0A8I3MX90
uniprot id: A0A8I3N0J9
uniprot id: A0A8I3RSQ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:IER2
gene id: 9615:IER2
uniprot id: A0A8C0TH38
uniprot id: A0A8I3S7L7
names: Similarity
messages: Belongs to the IER family.

9615:TIPRL
gene id: 9615:TIPRL
uniprot id: A0A8C0RV66
uniprot id: A0A8I3MP00
names: Similarity
messages: Belongs to the TIP41 family.

9615:POU1F1
gene id: 9615:POU1F1
uniprot id: Q9TTI7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Interacts with PITX1. Interacts with LHX3. Interacts with ELK1.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

9615:MC5R
gene id: 9615:MC5R
uniprot id: A0A8P0N3F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

9615:RRAGB
gene id: 9615:RRAGB
uniprot id: A0A8C0TAR4
uniprot id: A0A8C0Z2K1
uniprot id: A0A8P0P2Q6
uniprot id: A0A8P0SKS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9615:SEPTIN6
gene id: 9615:SEPTIN6
uniprot id: A0A8C0SLX1
uniprot id: A0A8C0SMA7
uniprot id: A0A8C0SQY4
uniprot id: A0A8I3PE43
uniprot id: A0A8I3S249
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9615:SNRPD3
gene id: 9615:SNRPD3
uniprot id: A0A8C0P7E3
uniprot id: A0A8I3PG61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9615:ATP2B2
gene id: 9615:ATP2B2
uniprot id: A0A8C0TL23
uniprot id: A0A8I3RVD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SLC12A6
gene id: 9615:SLC12A6
uniprot id: A0A8C0RRJ4
uniprot id: A0A8C0RRK2
uniprot id: A0A8C0TQS1
uniprot id: A0A8I3P4U1
uniprot id: A0A8I3P9I5
uniprot id: A0A8I3S428
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9615:HSCB
gene id: 9615:HSCB
uniprot id: A0A8C0RTJ5
uniprot id: A0A8I3SCK5
names: Similarity
messages: Belongs to the HscB family.

9615:HDHD3
gene id: 9615:HDHD3
uniprot id: A0A8C0Q351
uniprot id: A0A8P0N652
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9615:C21H11orf54
gene id: 9615:C21H11orf54
uniprot id: A0A8I3S218
uniprot id: A0A8I3S4N7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9615:TSG101
gene id: 9615:TSG101
uniprot id: A0A8C0PA96
uniprot id: A0A8I3P8P4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

9615:NUP85
gene id: 9615:NUP85
uniprot id: A0A8C0RWU8
uniprot id: A0A8I3PUC1
uniprot id: A0A8I3PY62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9615:EVX1
gene id: 9615:EVX1
uniprot id: A0A8C0YTZ1
uniprot id: A0A8I3P7S7
names: Subcellular Location Annotation
messages: Nucleus

9615:RHCG
gene id: 9615:RHCG
uniprot id: Q3BCQ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion (By similarity).
messages: Homotrimer.
messages: N-glycosylated.

9615:KCNJ16
gene id: 9615:KCNJ16
uniprot id: A0A8C0M1I9
uniprot id: E0WCW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9615:SLC5A10
gene id: 9615:SLC5A10
uniprot id: A0A8I3P9Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9615:DUSP7
gene id: 9615:DUSP7
uniprot id: A0A8C0TK06
uniprot id: A0A8I3Q5N5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9615:NOC3L
gene id: 9615:NOC3L
uniprot id: A0A8C0TKK5
uniprot id: A0A8I3PI43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

9615:MYO18A
gene id: 9615:MYO18A
uniprot id: A0A8C0MVZ3
uniprot id: A0A8C0TM38
uniprot id: A0A8I3NEU8
uniprot id: A0A8I3NRI2
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MYH7
gene id: 9615:MYH7
uniprot id: P49824
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with ECPAS. Interacts (via C-terminus) with LRRC39.
messages: Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
messages: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).
messages: The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Four skip residues (Skip1: Thr-1188, Skip2: Glu-1385, Skip3: Glu-1582 and Skip4: Gly-1807) introduce discontinuities in the coiled-coil heptad repeats. The first three skip residues are structurally comparable and induce a unique local relaxation of the coiled-coil superhelical pitch and the fourth skip residue lies within a highly flexible molecular hinge that is necessary for myosin incorporation in the bare zone of sarcomeres.
messages: myofibril
messages: sarcomere

9615:SLC7A8
gene id: 9615:SLC7A8
uniprot id: A0A8C0PSI8
uniprot id: A0A8I3MLB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9615:FXN
gene id: 9615:FXN
uniprot id: A0A8C0PRQ8
uniprot id: A6Q0K4
names: Similarity
messages: Belongs to the frataxin family.

9615:TXNRD2
gene id: 9615:TXNRD2
uniprot id: A0A8P0P0L3
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

9615:B3GALT5
gene id: 9615:B3GALT5
uniprot id: A0A8I3Q8H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:SZRD1
gene id: 9615:SZRD1
uniprot id: A0A8C0Q065
uniprot id: A0A8I3MLT9
names: Similarity
messages: Belongs to the SZRD1 family.

9615:CLDN18
gene id: 9615:CLDN18
uniprot id: A0A8C0N3B4
uniprot id: A0A8C0TMZ8
uniprot id: A0A8I3PMY9
uniprot id: A0A8I3PV36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:STX19
gene id: 9615:STX19
uniprot id: A0A8C0T9L9
uniprot id: A0A8I3SCR5
names: Similarity
messages: Belongs to the syntaxin family.

9615:CAMK1
gene id: 9615:CAMK1
uniprot id: A0A8C0TTB3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:LOC100687687
gene id: 9615:LOC100687687
uniprot id: A0A8C0S089
uniprot id: A0A8I3MGC7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9615:GPR156
gene id: 9615:GPR156
uniprot id: A0A8C0MXF4
uniprot id: A0A8I3P4R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:HOXC10
gene id: 9615:HOXC10
uniprot id: A0A8C0RNF2
uniprot id: A0A8I3S375
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9615:NR2C1
gene id: 9615:NR2C1
uniprot id: A0A8C0NG70
uniprot id: A0A8I3PQ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:FANCM
gene id: 9615:FANCM
uniprot id: A0A8P0NSJ1
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

9615:GNG4
gene id: 9615:GNG4
uniprot id: A0A8C0PRI2
uniprot id: A0A8I3ML62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:SEZ6L
gene id: 9615:SEZ6L
uniprot id: A0A8P0NDN1
uniprot id: A0A8P0PE68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:DPP7
gene id: 9615:DPP7
uniprot id: A0A8I3PJI1
names: Similarity
messages: Belongs to the peptidase S28 family.

9615:LOC100684060
gene id: 9615:LOC100684060
uniprot id: A0A8C0Z038
uniprot id: A0A8I3PEE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:PSME1
gene id: 9615:PSME1
uniprot id: A0A8C0N6F6
uniprot id: A0A8I3MU16
names: Similarity
messages: Belongs to the PA28 family.

9615:EGR1
gene id: 9615:EGR1
uniprot id: A0A8C0SPV5
uniprot id: A0A8I3PHY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9615:NKIRAS2
gene id: 9615:NKIRAS2
uniprot id: A0A8C0S1Q6
uniprot id: A0A8I3N5X1
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9615:XRCC3
gene id: 9615:XRCC3
uniprot id: A0A8I3PAY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

9615:HSD17B2
gene id: 9615:HSD17B2
uniprot id: A0A8C0T286
uniprot id: A0A8I3P923
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:YIPF5
gene id: 9615:YIPF5
uniprot id: A0A8C0QHW2
uniprot id: A0A8I3P483
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9615:CLCC1
gene id: 9615:CLCC1
uniprot id: A0A8P0NL19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

9615:SLC30A2
gene id: 9615:SLC30A2
uniprot id: A0A8C0NJA6
uniprot id: A0A8I3NLD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9615:SPTY2D1
gene id: 9615:SPTY2D1
uniprot id: A0A8C0TRE6
uniprot id: A0A8P0SR77
names: Similarity
messages: Belongs to the SPT2 family.

9615:SNRPA1
gene id: 9615:SNRPA1
uniprot id: A0A8C0M2V0
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9615:MRPL1
gene id: 9615:MRPL1
uniprot id: A0A8C0NYA7
uniprot id: A0A8I3NXX0
names: Subcellular Location Annotation
messages: Mitochondrion

9615:PPP2R2C
gene id: 9615:PPP2R2C
uniprot id: A0A8C0RVD5
uniprot id: A0A8I3N643
uniprot id: A0A8P0SIY7
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9615:DCLRE1B
gene id: 9615:DCLRE1B
uniprot id: A0A8P0PHX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9615:INPP5K
gene id: 9615:INPP5K
uniprot id: A0A8P0PJ21
uniprot id: A0A8P0SN39
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9615:MAP4K2
gene id: 9615:MAP4K2
uniprot id: A0A8C0MFB8
uniprot id: A0A8P0NFW2
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9615:MRPL19
gene id: 9615:MRPL19
uniprot id: A0A8C0QHG7
uniprot id: A0A8I3P0B6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9615:HEY1
gene id: 9615:HEY1
uniprot id: Q9TSZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEY family.
messages: Nucleus
messages: Self-associates. Interacts with HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A. Interacts with GATA4 and GATA6. Interacts with CCDC89/BOIP.
messages: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.

9615:ANXA1
gene id: 9615:ANXA1
uniprot id: A0A8C0PB64
uniprot id: A0A8I3M9P4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9615:KCNH5
gene id: 9615:KCNH5
uniprot id: A0A8C0PAV0
uniprot id: A0A8I3S7S4
names: Subcellular Location Annotation
messages: Membrane

9615:KRT4
gene id: 9615:KRT4
uniprot id: A0A8C0RP12
names: Similarity
messages: Belongs to the intermediate filament family.

9615:HPS3
gene id: 9615:HPS3
uniprot id: A0A8C0MM68
uniprot id: A0A8C0S4K0
uniprot id: A0A8I3PDG5
uniprot id: A0A8I3S3J8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9615:LAPTM4B
gene id: 9615:LAPTM4B
uniprot id: A0A8C0NNC7
uniprot id: A0A8I3S7G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAPTM4/LAPTM5 transporter family.
messages: Cell membrane
messages: Cell projection
messages: Endomembrane system
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: multivesicular body lumen
messages: multivesicular body membrane

9615:IL18R1
gene id: 9615:IL18R1
uniprot id: A0A8C0QQY0
uniprot id: A0A8I3N4M4
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9615:NUDC
gene id: 9615:NUDC
uniprot id: A0A8C0PXV1
uniprot id: A0A8I3N734
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9615:BANF2
gene id: 9615:BANF2
uniprot id: A0A8C0Z6K1
uniprot id: A0A8I3P4W0
names: Subcellular Location Annotation
messages: Nucleus

9615:DNAJC27
gene id: 9615:DNAJC27
uniprot id: A0A8C0QEK7
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9615:S100A4
gene id: 9615:S100A4
uniprot id: A0A346JM02
uniprot id: Q9TV56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the S-100 family.
messages: Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity).
messages: Cytoplasm
messages: Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode. Interacts with PGLYRP1; this complex acts as a chemoattractant that promotes lymphocyte movement. Interacts with MYH9; this interaction increases cell motility. Interacts with Annexin 2/ANXA2. Interacts with TP53; this interaction promotes TP53 degradation. Interacts with CCR5 and CXCR3. Interacts with FCGR3A; this interaction inhibits PKC-dependent phosphorylation of FCGR3A.
messages: Nucleus
messages: Secreted

9615:ITPKB
gene id: 9615:ITPKB
uniprot id: A0A8P0PQ55
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9615:OR7A54
gene id: 9615:OR7A54
uniprot id: A0A8C0PFQ8
uniprot id: A0A8I3PFU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ADAT2
gene id: 9615:ADAT2
uniprot id: A0A8P0N3J8
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9615:UOX
gene id: 9615:UOX
uniprot id: Q5FZI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

9615:BSCL2
gene id: 9615:BSCL2
uniprot id: A0A8C0RDX1
uniprot id: A0A8I3N5X2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:VPS13C
gene id: 9615:VPS13C
uniprot id: A0A8P0SL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

9615:ATP6V1H
gene id: 9615:ATP6V1H
uniprot id: A0A8C0RPZ2
uniprot id: A0A8C0TUQ6
uniprot id: A0A8I3PPK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9615:EMP1
gene id: 9615:EMP1
uniprot id: A0A8P0SR25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9615:RPL34
gene id: 9615:RPL34
uniprot id: A0A5F4D4Q9
uniprot id: A0A8C0PL86
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9615:SPNS1
gene id: 9615:SPNS1
uniprot id: A0A8C0RSU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9615:CABIN1
gene id: 9615:CABIN1
uniprot id: A0A8P0NNM3
names: Subcellular Location Annotation
messages: Nucleus

9615:ACTR6
gene id: 9615:ACTR6
uniprot id: A0A8C0RM92
uniprot id: A0A8I3MYA7
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

9615:CYP17A1
gene id: 9615:CYP17A1
uniprot id: A0A8C0PJZ0
uniprot id: A0A8C0TRG3
uniprot id: A0A8I3PR85
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:RPS4X
gene id: 9615:RPS4X
uniprot id: A0A8C0SBE5
uniprot id: A0A8I3PBZ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9615:INKA1
gene id: 9615:INKA1
uniprot id: A0A8C0SYV9
uniprot id: A0A8P0SRV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9615:NSUN3
gene id: 9615:NSUN3
uniprot id: A0A8C0NWZ8
uniprot id: A0A8I3SCR6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9615:SLC35A1
gene id: 9615:SLC35A1
uniprot id: A0A8C0S206
uniprot id: Q8WMR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9615:SGO1
gene id: 9615:SGO1
uniprot id: A0A8P0N8D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9615:AQP8
gene id: 9615:AQP8
uniprot id: A0A8C0PAZ6
uniprot id: A0A8I3MCV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:WNT10A
gene id: 9615:WNT10A
uniprot id: A0A8C0TSA8
uniprot id: A0A8I3QPH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:MEP1A
gene id: 9615:MEP1A
uniprot id: A0A8C0SJ13
uniprot id: A0A8I3S000
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:FMO2
gene id: 9615:FMO2
uniprot id: A0A8C0PJD9
uniprot id: A0A8I3RPX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9615:HOXB7
gene id: 9615:HOXB7
uniprot id: A0A8C0RAK9
uniprot id: A0A8I3NDH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:ZC3H12A
gene id: 9615:ZC3H12A
uniprot id: A0A8C0NPH1
uniprot id: A0A8P0N694
names: Similarity
messages: Belongs to the ZC3H12 family.

9615:CRY2
gene id: 9615:CRY2
uniprot id: A0A8C0Z2W2
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9615:PCMTD1
gene id: 9615:PCMTD1
uniprot id: A0A8C0P497
uniprot id: A0A8I3Q157
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9615:XPO5
gene id: 9615:XPO5
uniprot id: A0A8C0N5B7
uniprot id: A0A8C0QGU2
uniprot id: A0A8I3RXA6
names: Subcellular Location Annotation
messages: Cytoplasm

9615:PAIP2B
gene id: 9615:PAIP2B
uniprot id: A0A8C0Z621
uniprot id: A0A8I3PDA7
names: Similarity
messages: Belongs to the PAIP2 family.

9615:SLCO2A1
gene id: 9615:SLCO2A1
uniprot id: Q5FX75
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SIM1
gene id: 9615:SIM1
uniprot id: A0A8C0Q6A7
uniprot id: A0A8I3MZE5
names: Subcellular Location Annotation
messages: Nucleus

9615:TMEM178B
gene id: 9615:TMEM178B
uniprot id: A0A8I3Q619
names: Similarity
messages: Belongs to the TMEM178 family.

9615:TMEM184B
gene id: 9615:TMEM184B
uniprot id: A0A8C0QHH0
uniprot id: A0A8I3PRV6
names: Subcellular Location Annotation
messages: Membrane

9615:SLX1A
gene id: 9615:SLX1A
uniprot id: A0A8C0LY20
uniprot id: A0A8I3MM76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
messages: Forms a heterodimer with SLX4.
messages: Nucleus

9615:ZHX3
gene id: 9615:ZHX3
uniprot id: A0A8C0TBT4
uniprot id: A0A8I3Q3A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9615:LOC611632
gene id: 9615:LOC611632
uniprot id: A0A8C0MV44
names: Similarity
messages: Belongs to the multicopper oxidase family.

9615:SCP2
gene id: 9615:SCP2
uniprot id: A0A8I3S339
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion
messages: Peroxisome

9615:OSBPL3
gene id: 9615:OSBPL3
uniprot id: A0A8C0QM67
uniprot id: A0A8C0QPP8
uniprot id: A0A8P0PCL0
uniprot id: A0A8P0S8L2
uniprot id: A0A8P0S8M1
names: Similarity
messages: Belongs to the OSBP family.

9615:SBNO1
gene id: 9615:SBNO1
uniprot id: A0A8C0TQJ2
names: Similarity
messages: Belongs to the SBNO family.

9615:MLST8
gene id: 9615:MLST8
uniprot id: A0A8C0RUG6
uniprot id: A0A8I3MX71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9615:FBXO34
gene id: 9615:FBXO34
uniprot id: A0A8I3NKL9
uniprot id: A0A8P0TVB3
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9615:PRRC1
gene id: 9615:PRRC1
uniprot id: A0A8C0PKX5
uniprot id: A0A8I3NCY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

9615:VHL
gene id: 9615:VHL
uniprot id: Q5Q9Z2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VHL family.
messages: Component of the VBC (VHL-Elongin BC-CUL2) complex; this complex acts as a ubiquitin-ligase E3 and directs proteasome-dependent degradation of targeted proteins. Interacts with CUL2; this interaction is dependent on the integrity of the trimeric VBC complex. Interacts (via the beta domain) with HIF1A (via the NTAD domain); this interaction mediates degradation of HIF1A in normoxia and, in hypoxia, prevents ubiquitination and degradation of HIF1A by mediating hypoxia-induced translocation to the nucleus, a process which requires a hypoxia-dependent regulatory signal. Interacts with ADRB2; the interaction, in normoxia, is dependent on hydroxylation of ADRB2 and the subsequent VCB-mediated ubiquitination and degradation of ADRB2. Under hypoxia, hydroxylation, interaction with VHL, ubiquitination and subsequent degradation of ADRB2 are dramatically decreased. Interacts with RNF139, USP33 and JADE1 (By similarity). Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Interacts with LIMD1 (via LIM zinc-binding 2). Interacts with AJUBA (via LIM domains) and WTIP (via LIM domains) (By similarity). Interacts with EPAS1. Interacts with CARD9 (By similarity). Interacts with DCUN1D1 independently of CUL2; this interaction engages DCUN1D1 in the VCB complex and triggers CUL2 neddylation and consequently cullin ring ligase (CRL) substrates polyubiquitylation (By similarity). Interacts with ALAS1 (hydroxylated form) (By similarity).
messages: Cytoplasm
messages: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (By similarity).
messages: Membrane
messages: Nucleus
messages: The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

9615:SMARCA4
gene id: 9615:SMARCA4
uniprot id: A0A8C0T0C2
uniprot id: A0A8I3PJ19
uniprot id: A0A8I3PJC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9615:TGS1
gene id: 9615:TGS1
uniprot id: A0A8C0TW44
uniprot id: A0A8I3PUL6
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9615:TLR4
gene id: 9615:TLR4
uniprot id: A0A8C0YS26
uniprot id: Q8SQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9615:SOAT1
gene id: 9615:SOAT1
uniprot id: A0A8I3N1B2
uniprot id: A0A8I3N2Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:RGS7BP
gene id: 9615:RGS7BP
uniprot id: A0A8C0Q3F6
uniprot id: A0A8P0N9M5
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9615:MBOAT7
gene id: 9615:MBOAT7
uniprot id: A0A8C0LWR4
uniprot id: A0A8C0RAI2
uniprot id: A0A8I3MRI3
uniprot id: A0A8P0SR76
names: Subcellular Location Annotation
messages: Membrane

9615:BORCS5
gene id: 9615:BORCS5
uniprot id: A0A8C0TL03
uniprot id: A0A8I3PGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9615:SASS6
gene id: 9615:SASS6
uniprot id: A0A8P0SPF7
names: Subcellular Location Annotation
messages: centrosome

9615:CA1
gene id: 9615:CA1
uniprot id: A0A8C0Z3W7
uniprot id: A0A8I3S2I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9615:FNBP1L
gene id: 9615:FNBP1L
uniprot id: A0A8I3NR08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9615:NRXN2
gene id: 9615:NRXN2
uniprot id: A0A8P0SWQ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TUBGCP3
gene id: 9615:TUBGCP3
uniprot id: A0A8C0QCA5
uniprot id: A0A8I3PC49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9615:NPEPPS
gene id: 9615:NPEPPS
uniprot id: A0A8I3RYM4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9615:CDH7
gene id: 9615:CDH7
uniprot id: A0A8C0NEU1
uniprot id: A0A8I3MLV3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9615:PRLHR
gene id: 9615:PRLHR
uniprot id: A0A8C0PH07
uniprot id: A0A8P0NDT1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:CBLC
gene id: 9615:CBLC
uniprot id: A0A8C0LXC3
uniprot id: A0A8P0SA92
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9615:C6
gene id: 9615:C6
uniprot id: A0A8P0T891
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:RPL37
gene id: 9615:RPL37
uniprot id: A0A8C0MRI9
uniprot id: E2RR77
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9615:IRAK2
gene id: 9615:IRAK2
uniprot id: A0A8I3N5F6
uniprot id: A0A8I3N7V1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9615:LHX9
gene id: 9615:LHX9
uniprot id: A0A8I3PJH5
names: Subcellular Location Annotation
messages: Nucleus

9615:PAXBP1
gene id: 9615:PAXBP1
uniprot id: A0A8C0TU43
uniprot id: A0A8I3PXQ4
names: Similarity
messages: Belongs to the GCF family.

9615:MOS
gene id: 9615:MOS
uniprot id: A0A8C0NXU9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:CE9
gene id: 9615:CE9
uniprot id: Q9XSV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9615:TMEM106B
gene id: 9615:TMEM106B
uniprot id: A0A8C0NNS8
uniprot id: A0A8I3S576
names: Similarity
messages: Belongs to the TMEM106 family.

9615:ST6GAL1
gene id: 9615:ST6GAL1
uniprot id: A0A8C0T0L0
uniprot id: A0A8I3S5C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:PFDN6
gene id: 9615:PFDN6
uniprot id: Q5TJE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits (By similarity). Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (By similarity).

9615:ZNF397
gene id: 9615:ZNF397
uniprot id: A0A8C0S2X5
uniprot id: A0A8I3RTN6
names: Subcellular Location Annotation
messages: Nucleus

9615:PPARG
gene id: 9615:PPARG
uniprot id: Q4U3Q4
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Interacts with FOXO1 (acetylated form) (By similarity). Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG. Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters. Interacts with NOCT. Interacts with ACTN4. Interacts (when in the liganded conformation) with GPS2 (By similarity). Interacts with CRY1 and CRY2 in a ligand-dependent manner (By similarity). In the absence of hormonal ligand, interacts with TACC1 (By similarity).
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels.
messages: Nucleus
messages: PDPK1 activates its transcriptional activity independently of its kinase activity.
messages: Phosphorylated at basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation induces adipogenic activity (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9615:LOC100687029
gene id: 9615:LOC100687029
uniprot id: A0A8C0Q1G4
uniprot id: A0A8P0NMP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9615:ATP9B
gene id: 9615:ATP9B
uniprot id: A0A8C0M7J8
uniprot id: A0A8C0PW33
uniprot id: A0A8C0Q0F3
uniprot id: A0A8I3MA25
uniprot id: A0A8I3MEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:HOXC4
gene id: 9615:HOXC4
uniprot id: A0A8C0Z2X9
uniprot id: A0A8I3NZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:GBGT1
gene id: 9615:GBGT1
uniprot id: Q95158
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer) (PubMed:8855242, PubMed:10506200). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens such as E.coli uropathogenic strains (PubMed:10506200).
messages: Golgi apparatus membrane
messages: The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).

9615:UBA52
gene id: 9615:UBA52
uniprot id: P63050
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.
messages: Nucleus
messages: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.
messages: Ribosomal protein L40 is part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).
messages: Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

9615:APOLD1
gene id: 9615:APOLD1
uniprot id: A0A8P0T0C6
names: Similarity
messages: Belongs to the apolipoprotein L family.

9615:LHX2
gene id: 9615:LHX2
uniprot id: A0A8C0PPM4
uniprot id: A0A8I3RW43
names: Subcellular Location Annotation
messages: Nucleus

9615:MAT2A
gene id: 9615:MAT2A
uniprot id: A0A8C0N4M9
uniprot id: A0A8I3NU09
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9615:ARSL
gene id: 9615:ARSL
uniprot id: Q32KI1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:UTP11
gene id: 9615:UTP11
uniprot id: A0A8C0RXU2
uniprot id: A0A8I3Q8Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9615:RUVBL1
gene id: 9615:RUVBL1
uniprot id: A0A8I3P6G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9615:LOC489707
gene id: 9615:LOC489707
uniprot id: A0A8C0M2F2
uniprot id: A0A8I3PK22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9615:ARID5B
gene id: 9615:ARID5B
uniprot id: A0A8I3MRZ3
names: Similarity
messages: Belongs to the ARID5B family.

9615:CRYBA4
gene id: 9615:CRYBA4
uniprot id: A2ICR5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9615:DMAP1
gene id: 9615:DMAP1
uniprot id: A0A8C0N765
uniprot id: A0A8I3Q216
names: Subcellular Location Annotation
messages: Nucleus

9615:ZKSCAN4
gene id: 9615:ZKSCAN4
uniprot id: A0A8C0P1M4
uniprot id: A0A8P0PHP9
names: Subcellular Location Annotation
messages: Nucleus

9615:UBLCP1
gene id: 9615:UBLCP1
uniprot id: A0A8C0PYA1
uniprot id: A0A8I3MIL5
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9615:ARL5C
gene id: 9615:ARL5C
uniprot id: A0A8C0MWQ4
uniprot id: A0A8I3P0X4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9615:GINS3
gene id: 9615:GINS3
uniprot id: A0A8C0M1A6
uniprot id: A0A8I3RS22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9615:ADRA1A
gene id: 9615:ADRA1A
uniprot id: A0A8C0T458
uniprot id: A0A8I3NK63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9615:SNX20
gene id: 9615:SNX20
uniprot id: A0A8C0MTS2
uniprot id: A0A8I3N7A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9615:LOC751814
gene id: 9615:LOC751814
uniprot id: P19708
names: Disease Annotation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SAA family.
messages: Expressed by the liver; secreted in plasma.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.
messages: Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
messages: Secreted
messages: This protein is the precursor of amyloid protein A, which is formed by the removal of residues from the C-terminal end.
messages: Upon cytokine stimulation.

9615:LOC100686265
gene id: 9615:LOC100686265
uniprot id: A0A8I3P7T0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9615:ARHGEF3
gene id: 9615:ARHGEF3
uniprot id: A0A8C0PJ09
uniprot id: A0A8C0RSV7
uniprot id: A0A8I3PNP1
uniprot id: A0A8I3PQ10
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9615:GJB1
gene id: 9615:GJB1
uniprot id: A0A8C0TR63
uniprot id: E2QYR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:LOC100855486
gene id: 9615:LOC100855486
uniprot id: A0A8C0PWK0
uniprot id: A0A8I3PRQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9615:NIF3L1
gene id: 9615:NIF3L1
uniprot id: A0A8C0TGA9
uniprot id: A0A8I3QK70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9615:BABAM1
gene id: 9615:BABAM1
uniprot id: A0A8C0SQW2
uniprot id: A0A8I3PX17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9615:HGD
gene id: 9615:HGD
uniprot id: A0A8C0MZ30
uniprot id: A0A8P0NDB6
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9615:ERF
gene id: 9615:ERF
uniprot id: A0A8C0M8B1
uniprot id: A0A8I3MC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:PSMA5
gene id: 9615:PSMA5
uniprot id: A0A8C0NHD1
uniprot id: A0A8I3N3S4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9615:OR7A23
gene id: 9615:OR7A23
uniprot id: A0A8P0STH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:TPRG1
gene id: 9615:TPRG1
uniprot id: A0A8P0TSA7
names: Similarity
messages: Belongs to the TPRG1 family.

9615:GABRG1
gene id: 9615:GABRG1
uniprot id: A0A8C0RIQ2
uniprot id: A0A8I3NLX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:PLEKHA8
gene id: 9615:PLEKHA8
uniprot id: D2KC46
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
messages: Homodimer. Interacts with ARF1; the interaction together with phosphatidylinositol 4-phosphate binding is required for FAPP2 GlcCer transfer ability (By similarity).
messages: Membrane
messages: The PH domain of FAPPS binds the small GTPase ARF1 and phosphatidylinositol-4-phosphate (PtdIns4P) with high selectivity, and is required for recruitment of FAPPs to the trans-Golgi network (TGN).
messages: trans-Golgi network membrane

9615:LOC100687367
gene id: 9615:LOC100687367
uniprot id: A0A8I3MEY6
names: Subcellular Location Annotation
messages: Membrane

9615:OPN1LW
gene id: 9615:OPN1LW
uniprot id: O18914
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: The three color pigments are found in the cone photoreceptor cells.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

9615:KIAA1191
gene id: 9615:KIAA1191
uniprot id: A0A8C0M4I0
uniprot id: A0A8C0T0S5
uniprot id: A0A8I3NN97
uniprot id: A0A8I3NNF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9615:SNRPG
gene id: 9615:SNRPG
uniprot id: A0A8C0QKN0
uniprot id: J9P061
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9615:FOXP3
gene id: 9615:FOXP3
uniprot id: D0VYJ3
names: Subcellular Location Annotation
messages: Nucleus

9615:CXXC1
gene id: 9615:CXXC1
uniprot id: A0A8C0YW02
names: Subcellular Location Annotation
messages: Nucleus

9615:SLIT2
gene id: 9615:SLIT2
uniprot id: A0A8C0LX73
uniprot id: A0A8I3NDC9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:TBX18
gene id: 9615:TBX18
uniprot id: A0A8I3RX74
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:CDK4
gene id: 9615:CDK4
uniprot id: A0A8C0T1I9
uniprot id: A0A8I3NU36
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:PTH1R
gene id: 9615:PTH1R
uniprot id: Q9TU31
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: High levels in the kidney, with much lower levels in aorta, heart, lung, prostate, testis, and skeletal muscle.
messages: Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:12153143). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (By similarity).
messages: N-glycosylated.
messages: Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

9615:UQCC2
gene id: 9615:UQCC2
uniprot id: A0A8C0M741
uniprot id: A0A8I3PYH9
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9615:SUOX
gene id: 9615:SUOX
uniprot id: A0A8C0RXB4
uniprot id: A0A8P0N3B7
names: Function
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.

9615:PSMC1
gene id: 9615:PSMC1
uniprot id: A0A8C0LUS7
uniprot id: A0A8P0SLQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9615:H2BC21
gene id: 9615:H2BC21
uniprot id: A0A8C0MIB7
uniprot id: A0A8P0T098
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:BLOC1S2
gene id: 9615:BLOC1S2
uniprot id: A0A8C0T552
names: Similarity
messages: Belongs to the BLOC1S2 family.

9615:RPIA
gene id: 9615:RPIA
uniprot id: A0A8C0MIR6
uniprot id: A0A8I3NN17
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9615:NSDHL
gene id: 9615:NSDHL
uniprot id: A0A8C0P518
uniprot id: A0A8I3PAN9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9615:NIPAL1
gene id: 9615:NIPAL1
uniprot id: A0A8C0YS81
uniprot id: A0A8I3NNZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9615:CYGB
gene id: 9615:CYGB
uniprot id: Q00M97
names: Similarity
messages: Belongs to the globin family.

9615:BET1L
gene id: 9615:BET1L
uniprot id: A0A8C0ML66
uniprot id: A0A8I3PVR4
names: Subcellular Location Annotation
messages: Membrane

9615:SMARCAL1
gene id: 9615:SMARCAL1
uniprot id: A0A8C0P2A2
uniprot id: A0A8I3PRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9615:P4HA1
gene id: 9615:P4HA1
uniprot id: A0A8C0PN19
uniprot id: A0A8C0PSC4
uniprot id: A0A8I3N1J1
uniprot id: A0A8I3RT21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9615:EMC10
gene id: 9615:EMC10
uniprot id: A0A8C0M3S3
uniprot id: A0A8C0M3T3
uniprot id: A0A8I3NVZ8
uniprot id: A0A8I3P0P8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC10 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9615:DEFB118
gene id: 9615:DEFB118
uniprot id: Q30KT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:RPS6
gene id: 9615:RPS6
uniprot id: A0A8C0Z2B3
uniprot id: A0A8I3NUU7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

9615:SLC6A19
gene id: 9615:SLC6A19
uniprot id: A0A8C0MTV1
uniprot id: A0A8I3S5V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:ENSA
gene id: 9615:ENSA
uniprot id: A0A8C0MD80
uniprot id: A0A8I3P4A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9615:ATP6V1A
gene id: 9615:ATP6V1A
uniprot id: A0A8C0TRZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

9615:ACTN2
gene id: 9615:ACTN2
uniprot id: A0A8C0MXP0
names: Similarity
messages: Belongs to the alpha-actinin family.

9615:TAT
gene id: 9615:TAT
uniprot id: A0A8C0T2T1
uniprot id: A0A8I3MYF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9615:GMPPB
gene id: 9615:GMPPB
uniprot id: A0A8C0SY08
uniprot id: A0A8I3PK79
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9615:EIF3E
gene id: 9615:EIF3E
uniprot id: A0A8C0QGD6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.

9615:PCSK2
gene id: 9615:PCSK2
uniprot id: A0A8C0QBH0
uniprot id: A0A8I3P927
names: Similarity
messages: Belongs to the peptidase S8 family.

9615:PRDM10
gene id: 9615:PRDM10
uniprot id: A0A8C0M652
uniprot id: A0A8P0NCA0
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:BRCA1
gene id: 9615:BRCA1
uniprot id: Q95153
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote degradation (By similarity).
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1 (By similarity). Interacts with EXD2 (By similarity). Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme (By simila…
messages: Nucleus
messages: Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-987 by CHEK2 regulates mitotic spindle assembly. Phosphorylation by AURKA regulates centrosomal microtubule nucleation.
messages: The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the phosphorylated pSXXF motif of ABRAXAS1, recruits BRCA1 at DNA damage sites (By similarity).
messages: The RING-type zinc finger domain interacts with BAP1.

9615:MTMR10
gene id: 9615:MTMR10
uniprot id: A0A8C0T5R0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9615:TSPAN33
gene id: 9615:TSPAN33
uniprot id: A0A8I3PDH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:ADA2
gene id: 9615:ADA2
uniprot id: A0A8C0T1G5
uniprot id: A0A8I3QB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

9615:DNAAF4
gene id: 9615:DNAAF4
uniprot id: A0A8C0TYV5
uniprot id: A0A8I3Q1C1
names: Subcellular Location Annotation
messages: Dynein axonemal particle
messages: neuron projection

9615:HPN
gene id: 9615:HPN
uniprot id: A0A8C0RWA3
uniprot id: A0A8I3RRL2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TADA3
gene id: 9615:TADA3
uniprot id: A0A8C0MQY1
uniprot id: A0A8I3N7R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9615:DLGAP2
gene id: 9615:DLGAP2
uniprot id: A0A8I3P7E0
names: Similarity
messages: Belongs to the SAPAP family.

9615:XCR1
gene id: 9615:XCR1
uniprot id: A0A8C0T1R3
uniprot id: A0A8I3NL60
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:ANTXR2
gene id: 9615:ANTXR2
uniprot id: A0A8C0TFZ5
uniprot id: A0A8I3NTQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9615:PSMD11
gene id: 9615:PSMD11
uniprot id: A0A8C0SD27
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9615:GPR137B
gene id: 9615:GPR137B
uniprot id: A0A8I3RSK9
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9615:OLFML3
gene id: 9615:OLFML3
uniprot id: A0A8C0PP62
uniprot id: A0A8I3PPB1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:TCTN2
gene id: 9615:TCTN2
uniprot id: A0A8I3RZK2
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9615:GAR1
gene id: 9615:GAR1
uniprot id: A0A8C0PF87
uniprot id: A0A8I3S7F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9615:TCEA1
gene id: 9615:TCEA1
uniprot id: A0A8C0TX61
uniprot id: A0A8I3Q821
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9615:DHRS7C
gene id: 9615:DHRS7C
uniprot id: A0A8C0SN15
uniprot id: A0A8P0SLR1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:PLAC8A
gene id: 9615:PLAC8A
uniprot id: A0A8C0TNJ1
uniprot id: A0A8P0NMP9
names: Similarity
messages: Belongs to the cornifelin family.

9615:FIGNL1
gene id: 9615:FIGNL1
uniprot id: A0A8C0SRT2
uniprot id: A0A8I3N9F1
names: Similarity
messages: Belongs to the AAA ATPase family.

9615:MAP7
gene id: 9615:MAP7
uniprot id: A0A8C0M6U7
uniprot id: A0A8C0MDQ6
uniprot id: A0A8I3MR63
uniprot id: A0A8I3MYJ6
names: Similarity
messages: Belongs to the MAP7 family.

9615:PRPF19
gene id: 9615:PRPF19
uniprot id: A0A8C0QPA3
uniprot id: A0A8C0RQH3
uniprot id: A0A8I3PCM8
uniprot id: A0A8I3S308
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9615:FGF6
gene id: 9615:FGF6
uniprot id: A0A8C0TKR8
uniprot id: E2REX2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:NCOA2
gene id: 9615:NCOA2
uniprot id: A0A8C0MTL4
uniprot id: A0A8I3PQF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9615:TIGD6
gene id: 9615:TIGD6
uniprot id: A0A8C0YVA3
names: Subcellular Location Annotation
messages: Nucleus

9615:JPH1
gene id: 9615:JPH1
uniprot id: A0A8C0RJC9
uniprot id: A0A8I3QHX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9615:SESN3
gene id: 9615:SESN3
uniprot id: A0A8C0NQ27
uniprot id: A0A8I3NX72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9615:SKP1
gene id: 9615:SKP1
uniprot id: A0A8C0QKG1
uniprot id: A0A8I3NPT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

9615:PGM2L1
gene id: 9615:PGM2L1
uniprot id: A0A8P0N864
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9615:XYLT1
gene id: 9615:XYLT1
uniprot id: Q5QQ56
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embryonic and postnatal skeleton development, especially of the long bones.
messages: Contains 7 disulfide bonds.
messages: Golgi apparatus membrane
messages: Monomer.
messages: N-glycosylated.

9615:ILF3
gene id: 9615:ILF3
uniprot id: A0A8C0RMW4
uniprot id: A0A8C0Z167
uniprot id: A0A8I3PHU5
uniprot id: A0A8I3S4C9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:ALG11
gene id: 9615:ALG11
uniprot id: A0A8C0QG63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9615:RHBDL2
gene id: 9615:RHBDL2
uniprot id: A0A8C0NRL2
uniprot id: A0A8I3QX63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9615:UBE2A
gene id: 9615:UBE2A
uniprot id: A0A8C0NI27
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:ENTR1
gene id: 9615:ENTR1
uniprot id: A0A8I3MXN3
names: Similarity
messages: Belongs to the ENTR1 family.

9615:GDPD3
gene id: 9615:GDPD3
uniprot id: A0A8C0PP45
uniprot id: A0A8I3RRU9
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9615:DGKB
gene id: 9615:DGKB
uniprot id: A0A8C0NVJ3
uniprot id: A0A8C0P0K8
uniprot id: A0A8C0T5Y3
uniprot id: A0A8I3PU79
uniprot id: A0A8I3SAV0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9615:L3HYPDH
gene id: 9615:L3HYPDH
uniprot id: A0A8C0Q5Y1
uniprot id: A0A8I3P9F0
names: Similarity
messages: Belongs to the proline racemase family.

9615:SSTR1
gene id: 9615:SSTR1
uniprot id: Q49LX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with SKB1.
messages: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins (By similarity).

9615:PPP1R3B
gene id: 9615:PPP1R3B
uniprot id: A0A8C0P5H8
uniprot id: A0A8I3NCV8
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9615:SERPINA1
gene id: 9615:SERPINA1
uniprot id: A0A8P0SPL0
names: Similarity
messages: Belongs to the serpin family.

9615:MPC2
gene id: 9615:MPC2
uniprot id: A0A8C0RVP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9615:LRTOMT
gene id: 9615:LRTOMT
uniprot id: A0A8C0MZ85
uniprot id: A0A8I3NFY4
names: Subcellular Location Annotation
messages: Cytoplasm

9615:NIPSNAP1
gene id: 9615:NIPSNAP1
uniprot id: A0A8C0T7Z8
uniprot id: A0A8I3QYU2
names: Similarity
messages: Belongs to the NipSnap family.

9615:MANBAL
gene id: 9615:MANBAL
uniprot id: A0A8C0RTS5
uniprot id: A0A8I3SBD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9615:CXCL10
gene id: 9615:CXCL10
uniprot id: Q5KSV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Monomer, dimer, and tetramer. Interacts with CXCR3 (via N-terminus).
messages: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
messages: Secreted

9615:DDA1
gene id: 9615:DDA1
uniprot id: A0A8C0P4U1
names: Similarity
messages: Belongs to the DDA1 family.

9615:GRPEL1
gene id: 9615:GRPEL1
uniprot id: A0A8I3N3U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9615:PLA2G5
gene id: 9615:PLA2G5
uniprot id: A0A8C0QJ08
uniprot id: A0A8I3MP63
uniprot id: A0A8I3N470
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9615:UTRN
gene id: 9615:UTRN
uniprot id: Q5JCF5
names: Subcellular Location Annotation
messages: cytoskeleton

9615:TPK1
gene id: 9615:TPK1
uniprot id: A0A8C0YTB3
uniprot id: A0A8I3NER7
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9615:CRYAB
gene id: 9615:CRYAB
uniprot id: A0A8C0Q8G4
uniprot id: A0A8I3MR05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9615:LGALS3
gene id: 9615:LGALS3
uniprot id: A0A8C0M3X2
uniprot id: E5Q8W5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9615:CDK2AP1
gene id: 9615:CDK2AP1
uniprot id: A0A8C0TQZ1
uniprot id: A0A8I3P5R2
names: Similarity
messages: Belongs to the CDK2AP family.

9615:ANPEP
gene id: 9615:ANPEP
uniprot id: P79143
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with CCoV spike glycoprotein.
messages: (Microbial infection) Probable receptor for canine coronavirus (CCoV).
messages: Amino acids 1-191 are essential to mediate susceptibility to infection with CCV (in canine/human chimeric studies).
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
messages: Cell membrane
messages: Homodimer. Interacts with SLC6A19 (By similarity).
messages: May undergo proteolysis and give rise to a soluble form.
messages: N- and O-glycosylated.
messages: Sulfated.

9615:RBX1
gene id: 9615:RBX1
uniprot id: A0A8C0T401
uniprot id: A0A8I3NXW3
names: Similarity
messages: Belongs to the RING-box family.

9615:GSTK1
gene id: 9615:GSTK1
uniprot id: A0A8C0Q483
uniprot id: A0A8I3P2R0
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9615:FER1L5
gene id: 9615:FER1L5
uniprot id: A0A8P0N5G8
uniprot id: A0A8P0PPV0
names: Similarity
messages: Belongs to the ferlin family.

9615:SLC1A4
gene id: 9615:SLC1A4
uniprot id: A0A8C0Q4G4
uniprot id: A0A8P0S969
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9615:TRPM4
gene id: 9615:TRPM4
uniprot id: A0A8C0NQ48
names: Subcellular Location Annotation
messages: Membrane

9615:NKX6-2
gene id: 9615:NKX6-2
uniprot id: A0A8C0TUE3
uniprot id: A0A8I3PNH1
names: Subcellular Location Annotation
messages: Nucleus

9615:SLC9A5
gene id: 9615:SLC9A5
uniprot id: A0A8C0MLN6
uniprot id: A0A8I3RUZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9615:HOXB9
gene id: 9615:HOXB9
uniprot id: A0A8C0Q7U4
uniprot id: A0A8I3N8G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9615:PLAC1
gene id: 9615:PLAC1
uniprot id: A0A8I3PNQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9615:ZMYND10
gene id: 9615:ZMYND10
uniprot id: A0A8C0N6K9
uniprot id: A0A8I3PGZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite

9615:IRGQ
gene id: 9615:IRGQ
uniprot id: A0A8C0SIP4
uniprot id: A0A8I3M9Y7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9615:TPM4
gene id: 9615:TPM4
uniprot id: A0A0N9JE84
uniprot id: A0A8C0P9W8
uniprot id: A0A8C0RR32
uniprot id: A0A8C0T3W1
uniprot id: A0A8I3Q497
uniprot id: A0A8I3Q6P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9615:AAMP
gene id: 9615:AAMP
uniprot id: Q7YR70
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway (By similarity).

9615:AP2B1
gene id: 9615:AP2B1
uniprot id: A0A8C0NRZ9
uniprot id: A0A8C0Q5V5
uniprot id: A0A8I3NCI2
uniprot id: A0A8I3ND36
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9615:TMOD4
gene id: 9615:TMOD4
uniprot id: A0A8C0RFA6
uniprot id: A0A8I3PE86
names: Subcellular Location Annotation
messages: cytoskeleton

9615:ZSCAN22
gene id: 9615:ZSCAN22
uniprot id: A0A8C0PZ81
uniprot id: A0A8P0SUV0
names: Subcellular Location Annotation
messages: Nucleus

9615:RXFP2
gene id: 9615:RXFP2
uniprot id: Q5XM32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity).

9615:GDI1
gene id: 9615:GDI1
uniprot id: O97555
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Interacts with RHOH (By similarity). Interacts with the non-phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (By similarity).
messages: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
messages: trans-Golgi network

9615:FMOD
gene id: 9615:FMOD
uniprot id: A0A8C0SFD8
uniprot id: A0A8I3NYI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

9615:ITGA1
gene id: 9615:ITGA1
uniprot id: A0A8C0S0A1
uniprot id: A0A8I3MAW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:EARS2
gene id: 9615:EARS2
uniprot id: A0A8I3MJU3
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9615:OOEP
gene id: 9615:OOEP
uniprot id: Q0ZFW8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (By similarity). Thereby contributes to oocyte survival and the resumption and completion of meiosis (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).
messages: Belongs to the KHDC1 family.
messages: Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3, OOEP, and TLE6 (By similarity). Within the complex, interacts with NLRP5, KHDC3 and TLE6 (By similarity). As part of the SCMC interacts with the SCMC-associated protein NLRP4F (By similarity). The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments (By similarity). Forms a scaffold complex with KHDC3/FILIA, and interacts with BLM and TRIM25 at DNA replication forks (By similarity).
messages: Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.
messages: Cytoplasm
messages: Nucleus

9615:H1-4
gene id: 9615:H1-4
uniprot id: A0A8C0TUV9
uniprot id: A0A8I3PW81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9615:C1GALT1
gene id: 9615:C1GALT1
uniprot id: A0A8P0N5A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Membrane

9615:STK40
gene id: 9615:STK40
uniprot id: A0A8C0QE80
uniprot id: A0A8C0QG97
uniprot id: A0A8I3Q7U1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9615:JUNB
gene id: 9615:JUNB
uniprot id: A0A8C0NSJ2
uniprot id: A0A8I3RZ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9615:PANX1
gene id: 9615:PANX1
uniprot id: A0A8C0T182
uniprot id: A0A8P0S9S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9615:PARPBP
gene id: 9615:PARPBP
uniprot id: A0A8C0N4J4
uniprot id: A0A8I3RWL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9615:MST1R
gene id: 9615:MST1R
uniprot id: A0A8C0RIZ6
uniprot id: A0A8P0SPB9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:PFN4
gene id: 9615:PFN4
uniprot id: A0A8C0NUW6
uniprot id: A0A8I3PDC3
names: Similarity
messages: Belongs to the profilin family.

9615:TMEM86A
gene id: 9615:TMEM86A
uniprot id: A0A8C0P2V9
uniprot id: A0A8I3P610
uniprot id: A0A8P0SU62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9615:SLC11A2
gene id: 9615:SLC11A2
uniprot id: A0A8C0N689
uniprot id: A0A8I3RZ10
uniprot id: A0A8P0SD71
names: Function
names: Similarity
messages: Belongs to the NRAMP family.
messages: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

9615:UTP3
gene id: 9615:UTP3
uniprot id: A0A8C0QBL1
uniprot id: A0A8P0N5W0
names: Similarity
messages: Belongs to the SAS10 family.

9615:RPL8
gene id: 9615:RPL8
uniprot id: A0A8C0MCJ3
uniprot id: A0A8I3RWX4
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9615:CHPF
gene id: 9615:CHPF
uniprot id: A0A8C0S3G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9615:ELAVL4
gene id: 9615:ELAVL4
uniprot id: A0A8C0MJG3
uniprot id: A0A8I3PLG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9615:CNTNAP2
gene id: 9615:CNTNAP2
uniprot id: A0A8C0MJY0
uniprot id: A0A8I3NYJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9615:TSPYL2
gene id: 9615:TSPYL2
uniprot id: A0A8C0YYY1
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:CCR6
gene id: 9615:CCR6
uniprot id: A0A8C0PSS4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:TALDO1
gene id: 9615:TALDO1
uniprot id: A0A8C0SF39
uniprot id: H9GW87
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

9615:BLCAP
gene id: 9615:BLCAP
uniprot id: A0A8C0T230
uniprot id: A0A8I3PW53
names: Similarity
messages: Belongs to the BLCAP family.

9615:EFS
gene id: 9615:EFS
uniprot id: A0A8P0SGH4
names: Similarity
messages: Belongs to the CAS family.

9615:CLGN
gene id: 9615:CLGN
uniprot id: A0A8P0P723
uniprot id: E2RA18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum membrane
messages: Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).
messages: Interacts with PDILT. Interacts with ADAM2 (By similarity). Interacts with PPIB.

9615:CBD107
gene id: 9615:CBD107
uniprot id: Q30KU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:MMP20
gene id: 9615:MMP20
uniprot id: A0A8C0TF13
uniprot id: A0A8I3RPK2
names: Similarity
messages: Belongs to the peptidase M10A family.

9615:LOC489591
gene id: 9615:LOC489591
uniprot id: A0A8C0LXD1
uniprot id: A0A8I3NWZ4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9615:HBS1L
gene id: 9615:HBS1L
uniprot id: A0A8C0MBD6
uniprot id: A0A8P0P297
names: Subunit
messages: Interacts with the SKI complex.

9615:BNIP3
gene id: 9615:BNIP3
uniprot id: Q005W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9615:SUV39H2
gene id: 9615:SUV39H2
uniprot id: A0A8C0NE17
uniprot id: A0A8C0NNV8
uniprot id: A0A8I3NJS2
uniprot id: A0A8I3NL85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9615:FOXJ3
gene id: 9615:FOXJ3
uniprot id: A0A8C0PEZ8
uniprot id: A0A8I3NT45
names: Subcellular Location Annotation
messages: Nucleus

9615:ICAM5
gene id: 9615:ICAM5
uniprot id: A0A8P0NJD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9615:SLC6A3
gene id: 9615:SLC6A3
uniprot id: A0A8C0MTV2
uniprot id: B6EUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
messages: Cell membrane
messages: Membrane
messages: axon
messages: neuron projection

9615:ASZ1
gene id: 9615:ASZ1
uniprot id: A0A8C0N4W1
uniprot id: A0A8I3RUV9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9615:QSOX2
gene id: 9615:QSOX2
uniprot id: A0A8P0TN97
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

9615:IMPDH2
gene id: 9615:IMPDH2
uniprot id: A0A8C0Z3I3
uniprot id: A0A8I3Q7R1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9615:SEPTIN1
gene id: 9615:SEPTIN1
uniprot id: A0A8C0SKS0
uniprot id: A0A8P0NHZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9615:TTLL9
gene id: 9615:TTLL9
uniprot id: A0A8I3PC19
names: Similarity
messages: Belongs to the tubulin--tyrosine ligase family.

9615:FAM126A
gene id: 9615:FAM126A
uniprot id: A0A8C0QAC3
uniprot id: A0A8C0QI73
uniprot id: A0A8I3MZQ3
uniprot id: A0A8I3N7M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9615:WNT7A
gene id: 9615:WNT7A
uniprot id: A0A8C0SXG7
uniprot id: A0A8I3PNZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:OR7A53
gene id: 9615:OR7A53
uniprot id: A0A8C0PNT4
uniprot id: A0A8I3P7U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:VPS53
gene id: 9615:VPS53
uniprot id: A0A8C0NJH5
uniprot id: A0A8I3NLI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9615:AMBP
gene id: 9615:AMBP
uniprot id: A0A8P0NNX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9615:ZDHHC13
gene id: 9615:ZDHHC13
uniprot id: A0A8C0P7Z1
uniprot id: A0A8I3P1B7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:DNAAF6
gene id: 9615:DNAAF6
uniprot id: A0A8C0TH93
uniprot id: A0A8I3P2P8
names: Similarity
messages: Belongs to the PIH1 family.

9615:BMPR1A
gene id: 9615:BMPR1A
uniprot id: A0A8C0S7K5
uniprot id: A0A8I3MVJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9615:SIX2
gene id: 9615:SIX2
uniprot id: A0A8C0QI40
uniprot id: A0A8I3Q0I4
names: Subcellular Location Annotation
messages: Nucleus

9615:PLEC
gene id: 9615:PLEC
uniprot id: A0A8C0PF47
uniprot id: A0A8C0PF85
uniprot id: A0A8C0RTG1
uniprot id: A0A8I3MYH9
uniprot id: A0A8P0TAL9
uniprot id: A0A8P0TCM9
uniprot id: A0A8P0TGU1
names: Subcellular Location Annotation
messages: cytoskeleton

9615:CDC123
gene id: 9615:CDC123
uniprot id: A0A8C0Q6P0
uniprot id: A0A8I3MFM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9615:MFSD1
gene id: 9615:MFSD1
uniprot id: A0A8C0NSE6
uniprot id: A0A8I3PRU1
names: Subcellular Location Annotation
messages: Membrane

9615:PDE6A
gene id: 9615:PDE6A
uniprot id: Q28263
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Cell membrane
messages: Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
messages: Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP. This protein participates in processes of transmission and amplification of the visual signal.
messages: photoreceptor outer segment

9615:PLG
gene id: 9615:PLG
uniprot id: A0A8C0N481
uniprot id: A0A8I3MF27
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

9615:ACOXL
gene id: 9615:ACOXL
uniprot id: A0A8C0NLY9
uniprot id: A0A8I3N9Q9
names: Similarity
messages: Belongs to the acyl-CoA oxidase family.

9615:AHSA1
gene id: 9615:AHSA1
uniprot id: A0A8C0MDY8
uniprot id: A0A8I3N859
names: Similarity
messages: Belongs to the AHA1 family.

9615:IQCG
gene id: 9615:IQCG
uniprot id: A0A8C0TPA5
uniprot id: A0A8P0SHT2
uniprot id: A0A8P0TF57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9615:C5H11orf87
gene id: 9615:C5H11orf87
uniprot id: A0A8I3MHJ3
names: Subcellular Location Annotation
messages: Membrane

9615:INS
gene id: 9615:INS
uniprot id: P01321
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

9615:PNPLA7
gene id: 9615:PNPLA7
uniprot id: A0A8P0SNF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:DLK2
gene id: 9615:DLK2
uniprot id: A0A8C0RI76
uniprot id: A0A8P0N505
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:DLA-DMA
gene id: 9615:DLA-DMA
uniprot id: Q5TJG8
names: Similarity
messages: Belongs to the MHC class II family.

9615:BTNL9
gene id: 9615:BTNL9
uniprot id: A0A8C0QJ13
uniprot id: A0A8I3MZ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9615:AKAP5
gene id: 9615:AKAP5
uniprot id: A0A8C0QE01
uniprot id: A0A8I3MN52
names: Subcellular Location Annotation
messages: Membrane

9615:ATP6V0D2
gene id: 9615:ATP6V0D2
uniprot id: A0A8C0MQX9
uniprot id: A0A8I3NSM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9615:RAPSN
gene id: 9615:RAPSN
uniprot id: A0A8C0QM89
uniprot id: A0A8P0TGK5
names: Similarity
messages: Belongs to the RAPsyn family.

9615:XDH
gene id: 9615:XDH
uniprot id: A0A8C0NJ24
uniprot id: A0A8P0NN99
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Homodimer. Interacts with BTN1A1.
messages: Peroxisome

9615:STT3B
gene id: 9615:STT3B
uniprot id: E2RG47
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STT3 family.
messages: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation (PubMed:12887896).
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.
messages: Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane

9615:RRN3
gene id: 9615:RRN3
uniprot id: A0A8C0Q2E7
uniprot id: A0A8I3NAG1
names: Similarity
messages: Belongs to the RRN3 family.

9615:SLC12A1
gene id: 9615:SLC12A1
uniprot id: A0A8P0NT73
uniprot id: A0A8P0P3B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9615:LOC609445
gene id: 9615:LOC609445
uniprot id: A0A8C0TQ36
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:SCN1B
gene id: 9615:SCN1B
uniprot id: Q4PPC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
messages: Cell membrane
messages: Cell projection
messages: Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits. Interacts with SCN4A. Interacts with NFASC. Interacts with SCN10A (By similarity). Interacts with SCN1A. Interacts with SCN3A. Interacts with SCN5A. Interacts with SCN8A (By similarity).
messages: Perikaryon
messages: Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
messages: axon

9615:STN1
gene id: 9615:STN1
uniprot id: A0A8C0TUP0
uniprot id: A0A8I3SBD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9615:RPS25
gene id: 9615:RPS25
uniprot id: A0A8C0TC47
uniprot id: A0A8I3RR71
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

9615:LOC481674
gene id: 9615:LOC481674
uniprot id: H2B3G5
names: Allergen
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Causes an allergic reaction in human. Binds to IgE (PubMed:22104604, PubMed:22515174, PubMed:23464525, PubMed:23464491, PubMed:29207604, PubMed:30728436). Binds to IgE in 61% of the 44 patients tested allergic to both dog and cat dander (PubMed:22104604). Binds to IgE in 38% of the 100 patients tested allergic to dog dander (PubMed:22515174). Binds to IgE in all 3 patients tested allergic to both dog and horse dander (PubMed:23464491). Binds to IgE in 56% of the 32 Chinese children tested allergic to dog (PubMed:29207604). Binds to IgE in 47% of the 38 patients tested allergic to dog dander (PubMed:30728436). Causes activation of human basophils (PubMed:22515174, PubMed:29207604).
messages: Expressed in saliva (at protein level) (PubMed:23464525). Expressed in dander (at protein level) (PubMed:22515174, PubMed:23464525). According to PubMed:22104604, expressed in submaxillary gland (PubMed:22104604). In contrast, according to PubMed:22515174, not expressed in submaxillary gland. Expressed in bladder and skin, but not in tongue (PubMed:22515174).
messages: Monomer.
messages: Secreted

9615:COPS2
gene id: 9615:COPS2
uniprot id: A0A8C0Z205
uniprot id: A0A8P0NGK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

9615:PRPF3
gene id: 9615:PRPF3
uniprot id: A0A8C0MGA6
uniprot id: A0A8P0NDZ7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9615:GBP5
gene id: 9615:GBP5
uniprot id: A0A8I3P5U8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9615:LPAR4
gene id: 9615:LPAR4
uniprot id: A0A8C0MYB2
uniprot id: A0A8I3PJM2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:SRP68
gene id: 9615:SRP68
uniprot id: A0A8C0LWP4
uniprot id: Q00004
names: Caution
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6938958, PubMed:6413076). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:6938958, PubMed:6413076). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7S RNA), SRP72 binds to this complex subsequently (PubMed:8388879). The SRP complex possibly participates in the elongation arrest function (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Heterodimer with SRP72 (PubMed:6413076, PubMed:8388879). SRP68/SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (PubMed:6413076, PubMed:8388879). Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6938958, PubMed:6413076). Within the SRP complex, interacts (via C-terminus) with SRP72 (PubMed:6413076, PubMed:8388879).
messages: Sequence encodes 9 consecutive glycine residues instead of 15 (AA 9-23).
messages: Some authors found genomic clones that have 9 or 12 consecutive glycine residues instead of 15 (AA 9-27).
messages: The N-terminus is required for RNA-binding.
messages: nucleolus

9615:PDE6D
gene id: 9615:PDE6D
uniprot id: Q9XT54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains (PDE6A and PDE6B) and two inhibitory chains (gamma); has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane (By similarity). Interacts with prenylated GRK1 and GRK7 (By similarity). Interacts with prenylated INPP5E (By similarity). Interacts with prenylated Ras family members, including HRAS, KRAS, NRAS, RAP2A, RAP2C and RHEB (By similarity). Interacts with RAB13 (prenylated form); dissociates RAB13 from membranes (By similarity). Interacts with RPGR (By similarity). Interacts with ARL2 (By similarity). Interacts with ARL3; the interaction occurs specifically with the GTP-bound form of ARL3 (By similarity). Interaction with ARL2 and ARL3 promotes release of farnesylated cargo proteins (By similarity).
messages: Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).
messages: Retina.
messages: cilium basal body
messages: cytosol

9615:ISM1
gene id: 9615:ISM1
uniprot id: A0A8C0QCX1
uniprot id: A0A8I3PIF5
names: Similarity
messages: Belongs to the isthmin family.

9615:GANC
gene id: 9615:GANC
uniprot id: A0A8P0SF64
uniprot id: A0A8P0SSZ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9615:AP2M1
gene id: 9615:AP2M1
uniprot id: A0A8C0N3K7
uniprot id: A0A8I3PSX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9615:PPIH
gene id: 9615:PPIH
uniprot id: A0A8C0P8H4
uniprot id: A0A8I3P2F4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9615:FAR2
gene id: 9615:FAR2
uniprot id: A0A8C0T3P5
uniprot id: A0A8I3PFK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9615:RBL2
gene id: 9615:RBL2
uniprot id: A0A8C0MJZ3
uniprot id: A0A8I3N5E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9615:NKX2-6
gene id: 9615:NKX2-6
uniprot id: A0A8C0TEV1
uniprot id: A0A8I3NYD2
names: Subcellular Location Annotation
messages: Nucleus

9615:PIPOX
gene id: 9615:PIPOX
uniprot id: A0A8C0MVR2
uniprot id: A0A8I3NCN7
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9615:LOC491550
gene id: 9615:LOC491550
uniprot id: A0A8C0NCJ9
uniprot id: A0A8P0SJB7
names: Similarity
messages: Belongs to the threonine aldolase family.

9615:GPR83
gene id: 9615:GPR83
uniprot id: Q9TTQ9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN. Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors.
messages: NPY has been reported to be a ligand for GPR83 (By similarity). However, a more recent study found that radiolabeled PEN binding to GPR83 is not affected by NPY concentrations below 1 mM, only very high, non-physiological concentrations causes a partial, displacement of PEN binding (By similarity).

9615:MTFR1L
gene id: 9615:MTFR1L
uniprot id: A0A8C0NIQ3
uniprot id: A0A8I3NRG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9615:POLR2F
gene id: 9615:POLR2F
uniprot id: A0A8C0N6F8
uniprot id: A0A8I3MQQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9615:RPS7
gene id: 9615:RPS7
uniprot id: A0A8C0Q0X5
uniprot id: A0A8I3PNN7
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

9615:DPT
gene id: 9615:DPT
uniprot id: A0A8C0P924
uniprot id: A0A8I3RS96
uniprot id: E5G725
names: Similarity
messages: Belongs to the dermatopontin family.

9615:CCL16
gene id: 9615:CCL16
uniprot id: A0A8I3N166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:GPR142
gene id: 9615:GPR142
uniprot id: A0A8C0Q811
uniprot id: F1PLR4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:LOC100682542
gene id: 9615:LOC100682542
uniprot id: A0A8C0S4Y9
uniprot id: J9NZS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9615:SRRT
gene id: 9615:SRRT
uniprot id: A0A8I3MWW9
names: Similarity
messages: Belongs to the ARS2 family.

9615:RCAN1
gene id: 9615:RCAN1
uniprot id: A0A8C0PJW4
uniprot id: A0A8C0PPK3
uniprot id: A0A8I3PN72
uniprot id: A0A8I3Q8C4
names: Similarity
messages: Belongs to the RCAN family.

9615:ATRAID
gene id: 9615:ATRAID
uniprot id: A0A8C0MJS3
uniprot id: A0A8I3N4W1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CLEC18C
gene id: 9615:CLEC18C
uniprot id: A0A8C0SNR4
uniprot id: A0A8I3MPI1
uniprot id: A0A8I3MTT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:FABP4
gene id: 9615:FABP4
uniprot id: A0A8C0T7B6
uniprot id: A0A8I3NQN1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:CDK2
gene id: 9615:CDK2
uniprot id: A0A8C0NEG2
uniprot id: A0A8C0NMM0
uniprot id: A0A8I3MY98
uniprot id: A0A8I3N128
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:CETN1
gene id: 9615:CETN1
uniprot id: A0A8C0NMF1
uniprot id: A0A8I3RRP1
names: Similarity
messages: Belongs to the centrin family.

9615:TMED5
gene id: 9615:TMED5
uniprot id: A0A8C0MY53
uniprot id: A0A8I3NKL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with TMED9 and TMED10.
messages: Membrane
messages: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.
messages: cis-Golgi network membrane

9615:PEX7
gene id: 9615:PEX7
uniprot id: A0A8C0M240
uniprot id: A0A8C0PX07
uniprot id: A0A8I3N4T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

9615:ETV5
gene id: 9615:ETV5
uniprot id: A0A8C0RQH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:EXOC2
gene id: 9615:EXOC2
uniprot id: A0A8C0REU8
uniprot id: A0A8I3P3F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9615:LOC608550
gene id: 9615:LOC608550
uniprot id: A0A8C0Q3M6
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9615:GJD2
gene id: 9615:GJD2
uniprot id: A0A8C0PU52
uniprot id: A0A8I3QZQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:CYP26A1
gene id: 9615:CYP26A1
uniprot id: A0A8C0Z3N5
uniprot id: A0A8I3P076
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:TMEM45A
gene id: 9615:TMEM45A
uniprot id: A0A8C0THV1
uniprot id: A0A8I3P2Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9615:H2AC5
gene id: 9615:H2AC5
uniprot id: A0A5F4CIE3
uniprot id: A0A8C0NV55
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:LOC106558389
gene id: 9615:LOC106558389
uniprot id: A0A8C0P517
uniprot id: A0A8I3PKC2
names: Similarity
messages: Belongs to the profilin family.

9615:SERPINE2
gene id: 9615:SERPINE2
uniprot id: A0A8I3P2P6
names: Similarity
messages: Belongs to the serpin family.

9615:HARS1
gene id: 9615:HARS1
uniprot id: A0A8C0RDL4
uniprot id: A0A8I3MNZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9615:LEP
gene id: 9615:LEP
uniprot id: O02720
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP…
messages: Secreted

9615:CTLA4
gene id: 9615:CTLA4
uniprot id: A0A8C0TW59
uniprot id: Q9GKP2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9615:OPALIN
gene id: 9615:OPALIN
uniprot id: A0A8C0TS48
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9615:VPS33B
gene id: 9615:VPS33B
uniprot id: A0A8C0Q4T5
uniprot id: A0A8I3MEB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9615:ACAA1
gene id: 9615:ACAA1
uniprot id: A0A8C0Z0H1
uniprot id: A0A8I3Q466
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9615:ALOX12
gene id: 9615:ALOX12
uniprot id: A0A8C0MY34
uniprot id: A0A8P0NHJ0
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PAIP2
gene id: 9615:PAIP2
uniprot id: A0A8C0MA89
names: Similarity
messages: Belongs to the PAIP2 family.

9615:SPO11
gene id: 9615:SPO11
uniprot id: A0A8C0RTS7
uniprot id: A0A8C0SWK4
uniprot id: A0A8I3Q8P2
uniprot id: A0A8I3QL01
names: Similarity
messages: Belongs to the TOP6A family.

9615:PHB
gene id: 9615:PHB
uniprot id: A8W340
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9615:VDAC2
gene id: 9615:VDAC2
uniprot id: A0A8C0P0B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Mitochondrion outer membrane

9615:MOCOS
gene id: 9615:MOCOS
uniprot id: A0A8I3RS50
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

9615:ACBD5
gene id: 9615:ACBD5
uniprot id: A0A8I3MIL3
uniprot id: A0A8I3MPJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9615:MAN2A2
gene id: 9615:MAN2A2
uniprot id: A0A8P0PIB2
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9615:PGM2
gene id: 9615:PGM2
uniprot id: A0A8C0PRW0
uniprot id: A0A8I3MSC7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9615:LOC486151
gene id: 9615:LOC486151
uniprot id: A0A8C0RS14
uniprot id: A0A8I3S2D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

9615:RAD52
gene id: 9615:RAD52
uniprot id: A0A8C0TZH2
uniprot id: A0A8I3Q232
names: Similarity
messages: Belongs to the RAD52 family.

9615:AMER1
gene id: 9615:AMER1
uniprot id: A0A8C0T759
uniprot id: A0A8I3PTU0
names: Similarity
messages: Belongs to the Amer family.

9615:RPL35
gene id: 9615:RPL35
uniprot id: A0A8C0MCI0
uniprot id: A0A8I3N516
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9615:SEBOX
gene id: 9615:SEBOX
uniprot id: A0A8C0T9W0
uniprot id: A0A8I3N016
names: Subcellular Location Annotation
messages: Nucleus

9615:CRYZ
gene id: 9615:CRYZ
uniprot id: A0A8C0NY94
uniprot id: A0A8I3MU73
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9615:KRT5
gene id: 9615:KRT5
uniprot id: A0A8C0P4P0
names: Similarity
messages: Belongs to the intermediate filament family.

9615:ALPL
gene id: 9615:ALPL
uniprot id: A0A8I3MZ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

9615:CA6
gene id: 9615:CA6
uniprot id: Q865C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide. Its role in saliva is unknown (By similarity).
messages: Secreted

9615:AASDH
gene id: 9615:AASDH
uniprot id: A0A8C0RQ56
uniprot id: A0A8I3P014
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:KDELR3
gene id: 9615:KDELR3
uniprot id: A0A8C0QBK4
uniprot id: A0A8I3PJT5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:GJA1
gene id: 9615:GJA1
uniprot id: A0A654IEC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:MATK
gene id: 9615:MATK
uniprot id: A0A8P0NSA7
uniprot id: A0A8P0T2H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:CASC3
gene id: 9615:CASC3
uniprot id: A0A8C0Q268
uniprot id: A0A8I3N863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

9615:HIBCH
gene id: 9615:HIBCH
uniprot id: A0A8C0RLB1
uniprot id: A0A8I3S4X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9615:MAU2
gene id: 9615:MAU2
uniprot id: A0A8C0N5H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9615:LEPROTL1
gene id: 9615:LEPROTL1
uniprot id: A0A8C0Q1W2
uniprot id: A0A8I3NC88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9615:SDHD
gene id: 9615:SDHD
uniprot id: A0A8C0N536
uniprot id: A0A8C0N794
uniprot id: A0A8P0NZD6
uniprot id: A0A8P0T0V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9615:LOC106559170
gene id: 9615:LOC106559170
uniprot id: A0A8C0S668
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9615:HOATZ
gene id: 9615:HOATZ
uniprot id: A0A8P0SIX4
names: Similarity
messages: Belongs to the HOATZ family.

9615:S1PR1
gene id: 9615:S1PR1
uniprot id: W5VNF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:CASKIN2
gene id: 9615:CASKIN2
uniprot id: A0A8C0M9R6
uniprot id: A0A8I3PQL9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9615:ACE2
gene id: 9615:ACE2
uniprot id: C7ECV0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9615:XYLT2
gene id: 9615:XYLT2
uniprot id: Q5QQ50
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Active with either Mg(2+) or Mn(2+), but activity is highest when both are present.
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (By similarity). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity).
messages: Contains disulfide bonds.
messages: Golgi apparatus membrane
messages: Monomer.
messages: Secreted

9615:ITGB5
gene id: 9615:ITGB5
uniprot id: A0A8C0RMW5
uniprot id: A0A8I3QCJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9615:RPA3
gene id: 9615:RPA3
uniprot id: A0A8C0SS84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9615:CAPN5
gene id: 9615:CAPN5
uniprot id: A0A8C0P1B0
uniprot id: A0A8P0SAV5
names: Similarity
messages: Belongs to the peptidase C2 family.

9615:H1-5
gene id: 9615:H1-5
uniprot id: A0A8C0P557
uniprot id: A0A8I3P6L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9615:RAB22A
gene id: 9615:RAB22A
uniprot id: P51154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome membrane
messages: Interacts directly with ZFYVE20 (By similarity). Interacts (in its GTP-bound form) with RINL and RABGEF1 (By similarity). Binds EEA1 (PubMed:11870209).
messages: Late endosome
messages: Plays a role in endocytosis and intracellular protein transport (PubMed:11870209, PubMed:16537905). Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:11870209).
messages: phagosome
messages: phagosome membrane
messages: ruffle

9615:PSMD12
gene id: 9615:PSMD12
uniprot id: A0A8C0T990
uniprot id: A0A8I3PZT2
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9615:FOXN2
gene id: 9615:FOXN2
uniprot id: A0A8C0SFC2
uniprot id: A0A8I3MWA0
names: Subcellular Location Annotation
messages: Nucleus

9615:NT5C3B
gene id: 9615:NT5C3B
uniprot id: A0A8C0S4Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9615:TPP1
gene id: 9615:TPP1
uniprot id: Q9XSB8
names: Cofactor
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity (By similarity).
messages: Binds 1 Ca(2+) ion per subunit.
messages: Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).
messages: Lysosome
messages: Melanosome
messages: Monomer. Interacts with CLN5. Interacts with CLN3 (By similarity).

9615:CHST10
gene id: 9615:CHST10
uniprot id: A0A8C0NYD9
uniprot id: A0A8I3P218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:CRYBB1
gene id: 9615:CRYBB1
uniprot id: A0A8C0TU15
uniprot id: E2R5F6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9615:FGFBP1
gene id: 9615:FGFBP1
uniprot id: A0A8P0SJZ4
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9615:SGCE
gene id: 9615:SGCE
uniprot id: A0A8C0NMV4
uniprot id: A0A8C0NPB9
uniprot id: A0A8C0SFE6
uniprot id: A0A8I3P8I1
uniprot id: A0A8I3PFQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Golgi apparatus
messages: cytoskeleton
messages: dendrite
messages: sarcolemma

9615:ZFPM2
gene id: 9615:ZFPM2
uniprot id: A0A8C0PBQ0
uniprot id: B3FXQ6
names: Subcellular Location Annotation
messages: Nucleus

9615:BMPR1B
gene id: 9615:BMPR1B
uniprot id: A0A8I3PGL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9615:RPF1
gene id: 9615:RPF1
uniprot id: A0A8C0N9H8
uniprot id: A0A8I3MIX2
names: Subcellular Location Annotation
messages: nucleolus

9615:ATPSCKMT
gene id: 9615:ATPSCKMT
uniprot id: A0A8C0TPP0
uniprot id: A0A8I3PIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9615:CALHM3
gene id: 9615:CALHM3
uniprot id: A0A8P0NCJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9615:CNTNAP1
gene id: 9615:CNTNAP1
uniprot id: A0A8C0QJD5
uniprot id: A0A8P0NYA1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9615:PRR15L
gene id: 9615:PRR15L
uniprot id: A0A8P0NI82
names: Similarity
messages: Belongs to the PRR15 family.

9615:ACVRL1
gene id: 9615:ACVRL1
uniprot id: A0A7I8AUV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9615:SEPTIN2
gene id: 9615:SEPTIN2
uniprot id: A0A8C0RTU1
uniprot id: A0A8I3S4Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9615:ZDHHC22
gene id: 9615:ZDHHC22
uniprot id: A0A8C0MNF5
uniprot id: A0A8I3RUL4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:RARG
gene id: 9615:RARG
uniprot id: A0A8I3PMF5
uniprot id: A0A8I3S4U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:TBX20
gene id: 9615:TBX20
uniprot id: A0A8C0NFR0
uniprot id: A0A8I3Q4U5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:MST1
gene id: 9615:MST1
uniprot id: A0A8C0T252
uniprot id: A0A8P0NDD1
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CA9
gene id: 9615:CA9
uniprot id: A0A8C0RHE4
uniprot id: A0A8I3NCN1
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9615:PDCL3
gene id: 9615:PDCL3
uniprot id: A0A8C0SLN7
uniprot id: A0A8I3RZ44
names: Similarity
messages: Belongs to the phosducin family.

9615:POMT1
gene id: 9615:POMT1
uniprot id: A0A8P0SNS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9615:ACTA2
gene id: 9615:ACTA2
uniprot id: A0A8C0RPH5
uniprot id: A0A8I3Q4M4
names: Similarity
messages: Belongs to the actin family.

9615:TOR1A
gene id: 9615:TOR1A
uniprot id: A0A8C0Q807
uniprot id: A0A8I3PV70
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum lumen
messages: Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane.
messages: Membrane
messages: growth cone

9615:UBE2K
gene id: 9615:UBE2K
uniprot id: A0A8C0T480
uniprot id: A0A8C0T6H4
uniprot id: A0A8I3ML12
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:QTRT1
gene id: 9615:QTRT1
uniprot id: A0A8C0RMP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

9615:RRP12
gene id: 9615:RRP12
uniprot id: A0A8C0TWF1
names: Similarity
messages: Belongs to the RRP12 family.

9615:TPMT
gene id: 9615:TPMT
uniprot id: Q8HX86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9615:ASB17
gene id: 9615:ASB17
uniprot id: A0A8C0PL69
uniprot id: A0A8I3MWR8
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9615:UBE2S
gene id: 9615:UBE2S
uniprot id: A0A8C0M095
uniprot id: A0A8I3MFS7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:PLAU
gene id: 9615:PLAU
uniprot id: A0A8C0RW08
uniprot id: A0A8I3NA75
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9615:ACVR1
gene id: 9615:ACVR1
uniprot id: A0A8C0MPL7
uniprot id: A0A8I3PSN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9615:PTPN11
gene id: 9615:PTPN11
uniprot id: A0A4D6PF96
uniprot id: A0A8C0TMQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9615:PHC2
gene id: 9615:PHC2
uniprot id: A0A8C0NB60
uniprot id: A0A8C0RK23
uniprot id: A0A8C0Z2B6
uniprot id: A0A8P0NCC5
uniprot id: A0A8P0NSR1
names: Subcellular Location Annotation
messages: Nucleus

9615:ST13
gene id: 9615:ST13
uniprot id: A0A8C0T3A6
uniprot id: A0A8I3NYR1
names: Similarity
messages: Belongs to the FAM10 family.

9615:WNT9B
gene id: 9615:WNT9B
uniprot id: A0A8I3PG82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:ATOH7
gene id: 9615:ATOH7
uniprot id: A0A8C0MIB6
uniprot id: A0A8I3MJH2
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

9615:KRT85
gene id: 9615:KRT85
uniprot id: A0A8C0SZG6
uniprot id: A0A8I3S5Q3
names: Similarity
messages: Belongs to the intermediate filament family.

9615:MFSD6L
gene id: 9615:MFSD6L
uniprot id: A0A8C0N9Q1
uniprot id: A0A8P0SLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9615:TMEM131L
gene id: 9615:TMEM131L
uniprot id: A0A8C0YW68
uniprot id: A0A8I3N604
names: Similarity
messages: Belongs to the TMEM131 family.

9615:ICMT
gene id: 9615:ICMT
uniprot id: A0A8C0RE09
uniprot id: A0A8I3PFI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:CAV1
gene id: 9615:CAV1
uniprot id: P33724
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer (PubMed:7568142). Interacts with BMX, BTK, GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with SLC7A9 (By similarity). Interacts with CTNNB1, CDH1 and JUP (PubMed:10816572). Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner (By similarity). Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation (By similarity). Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: Membrane raft
messages: Phosphorylation of isoform Beta on serine residues is constitutive. Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress (By similarity).
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.
messages: caveola
messages: trans-Golgi network

9615:AIDA
gene id: 9615:AIDA
uniprot id: A0A8C0P6L2
uniprot id: A0A8I3Q3P5
names: Similarity
messages: Belongs to the AIDA family.

9615:TBCB
gene id: 9615:TBCB
uniprot id: A0A8C0T3Z6
uniprot id: A0A8I3MF18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

9615:SPCS2
gene id: 9615:SPCS2
uniprot id: Q28250
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SEC11A or SEC11C and SPCS1 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane

9615:KDM5C
gene id: 9615:KDM5C
uniprot id: Q38JA7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the JARID1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Both the JmjC domain and the JmjN domain are required for enzymatic activity.
messages: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
messages: Nucleus
messages: Part of two distinct complexes, one containing E2F6, and the other containing REST.
messages: The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.

9615:POLR2C
gene id: 9615:POLR2C
uniprot id: A0A8C0S8L6
uniprot id: A0A8I3RSP9
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9615:SLC9A3R1
gene id: 9615:SLC9A3R1
uniprot id: E2RGF3
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
messages: filopodium
messages: microvillus
messages: ruffle

9615:PIK3R1
gene id: 9615:PIK3R1
uniprot id: A0A8C0M840
uniprot id: A0A8C0PYF3
uniprot id: A0A8I3N971
uniprot id: A0A8I3NJ30
uniprot id: A0A8I3NK93
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9615:PRND
gene id: 9615:PRND
uniprot id: A0A8C0YRG9
uniprot id: A0A8I3PYZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9615:TSEN2
gene id: 9615:TSEN2
uniprot id: A0A8C0TFY8
uniprot id: A0A8I3Q1M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9615:PLPP1
gene id: 9615:PLPP1
uniprot id: A0A8C0PSQ9
uniprot id: A0A8I3PY74
uniprot id: A0A8I3S6B5
uniprot id: A0A8I3SAU2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

9615:PPM1B
gene id: 9615:PPM1B
uniprot id: A0A8C0N3R5
uniprot id: A0A8I3PZS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9615:LDLR
gene id: 9615:LDLR
uniprot id: A0A8P0SLN2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:GMPR2
gene id: 9615:GMPR2
uniprot id: A0A8C0NPE4
uniprot id: A0A8I3N2R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9615:MTFR2
gene id: 9615:MTFR2
uniprot id: A0A8C0MAX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9615:KALRN
gene id: 9615:KALRN
uniprot id: A0A8C0TNG2
uniprot id: A0A8P0SH79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm

9615:THEMIS2
gene id: 9615:THEMIS2
uniprot id: A0A8I3NU04
uniprot id: A0A8I3NU63
uniprot id: A0A8P0SGZ8
names: Similarity
messages: Belongs to the themis family.

9615:CXCR2
gene id: 9615:CXCR2
uniprot id: A0A8C0TK08
uniprot id: A0A8I3PZU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:PTGES2
gene id: 9615:PTGES2
uniprot id: A0A8C0SNP1
uniprot id: B4YY03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

9615:SUSD5
gene id: 9615:SUSD5
uniprot id: A0A8C0S9A2
uniprot id: A0A8I3PHF6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LOC119863880
gene id: 9615:LOC119863880
uniprot id: A0A8C0SQW3
uniprot id: A0A8I3MWA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

9615:CYB5R3
gene id: 9615:CYB5R3
uniprot id: Q0X0E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor.
messages: Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MTARC2 (By similarity). Interacts with MTLN; the interaction is required to maintain cellular lipid composition and leads to stimulation of mitochondrial respiratory complex I activity (By similarity).
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9615:NPB
gene id: 9615:NPB
uniprot id: A0A8C0PJT5
uniprot id: A0A8I3NAS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

9615:SRP54
gene id: 9615:SRP54
uniprot id: P61010
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6938958, PubMed:6413076). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6938958, PubMed:6413076). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (PubMed:6413076). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).

9615:ERLIN1
gene id: 9615:ERLIN1
uniprot id: A0A8C0T3T7
uniprot id: A0A8I3NZK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9615:DNAJC25
gene id: 9615:DNAJC25
uniprot id: A0A8C0SK74
uniprot id: A0A8P0N5Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

9615:LOC481634
gene id: 9615:LOC481634
uniprot id: A0A8C0QCS0
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9615:ADGRG7
gene id: 9615:ADGRG7
uniprot id: A0A8C0Z592
names: Subcellular Location Annotation
messages: Membrane

9615:CHST4
gene id: 9615:CHST4
uniprot id: A0A8I3RSR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9615:ATP6V0A2
gene id: 9615:ATP6V0A2
uniprot id: A0A8C0TK26
uniprot id: A0A8I3P989
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9615:ACKR4
gene id: 9615:ACKR4
uniprot id: A0A8C0MIY9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:TMEM176B
gene id: 9615:TMEM176B
uniprot id: A0A8C0PDT6
uniprot id: A0A8I3NBA0
names: Similarity
messages: Belongs to the TMEM176 family.

9615:KDM3A
gene id: 9615:KDM3A
uniprot id: A0A8C0SSR7
uniprot id: A0A8I3NDS9
names: Subcellular Location Annotation
messages: Nucleus

9615:PSMB5
gene id: 9615:PSMB5
uniprot id: A0A8C0RVG6
uniprot id: A0A8I3MNI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:CUL4B
gene id: 9615:CUL4B
uniprot id: A0A8C0P7H0
uniprot id: A0A8P0PE73
names: Similarity
messages: Belongs to the cullin family.

9615:AK6
gene id: 9615:AK6
uniprot id: A0A8C0RXH8
uniprot id: A0A8I3NND6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9615:OTUB2
gene id: 9615:OTUB2
uniprot id: A0A8I3MLD1
names: Similarity
messages: Belongs to the peptidase C65 family.

9615:MLH1
gene id: 9615:MLH1
uniprot id: A0A8C0MIS9
uniprot id: A0A8I3PV01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9615:SMIM8
gene id: 9615:SMIM8
uniprot id: A0A8I3RU80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9615:NME1
gene id: 9615:NME1
uniprot id: Q50KA9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the enzyme. Interaction with the SET complex inhibits exonuclease activity (By similarity).
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with PRUNE1. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Within this complex, interacts directly with SET. Also interacts with TREX1, but only following translocation to the nucleus.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity).
messages: Nucleus

9615:ALDH1B1
gene id: 9615:ALDH1B1
uniprot id: A0A8C0SUI3
uniprot id: A0A8I3NPF7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:IFNB1
gene id: 9615:IFNB1
uniprot id: B6E116
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha/beta interferon family.
messages: Monomer.
messages: Secreted

9615:CASP3
gene id: 9615:CASP3
uniprot id: Q8MKI5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.
messages: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).
messages: S-nitrosylated on its catalytic site cysteine in unstimulated cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.

9615:CMC1
gene id: 9615:CMC1
uniprot id: A0A8C0P0Z4
uniprot id: A0A8I3PLQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9615:ILDR1
gene id: 9615:ILDR1
uniprot id: A0A8P0SRQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9615:TP53
gene id: 9615:TP53
uniprot id: Q29537
names: Cofactor
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of Lys-370 by CREBBP enhances transcriptional activity. Acetylation of Lys-370 by EP300. Deacetylation of Lys-370 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-369 increases stability. Deacetylation at Lys-369 by SIRT6 decreases its stability, thereby regulating cell senescence.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-370) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interactio…
messages: Mitochondrion matrix
messages: Monomethylated at Lys-360 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-358 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-360 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-358. Dimethylated at Lys-361 by EHMT1 and EHMT2. Monomethylated at Lys-370 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-358 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-321 and dimethylated at Arg-323 and Arg-325 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).
messages: Nucleus
messages: PML body
messages: Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15 and Ser-33, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated at Ser-303 and Ser-380 by CDK2 in response to DNA-damage. Phosphorylated on Ser-380 following UV but not gamma irradiation (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).
messages: Sumoylated with SUMO1. Sumoylated at Lys-374 by UBC9 (By similarity).
messages: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
messages: Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity).
messages: centrosome
messages: p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.

9615:RNFT2
gene id: 9615:RNFT2
uniprot id: A0A8I3PSJ1
names: Subcellular Location Annotation
messages: Membrane

9615:SPIC
gene id: 9615:SPIC
uniprot id: A0A8P0N9P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:NOB1
gene id: 9615:NOB1
uniprot id: A0A8C0T7F4
uniprot id: A0A8I3N1B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9615:GRK2
gene id: 9615:GRK2
uniprot id: A0A8C0SDN0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9615:VPS45
gene id: 9615:VPS45
uniprot id: A0A8C0YSS2
uniprot id: A0A8I3NXE2
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9615:COA7
gene id: 9615:COA7
uniprot id: A0A8C0S5A3
uniprot id: A0A8I3S317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space

9615:MARVELD2
gene id: 9615:MARVELD2
uniprot id: A0A8C0QH94
uniprot id: A0A8I3NDA4
uniprot id: A0A8I3NM02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9615:SPTB
gene id: 9615:SPTB
uniprot id: A0A8P0TLN4
names: Similarity
messages: Belongs to the spectrin family.

9615:FOXR1
gene id: 9615:FOXR1
uniprot id: A0A8P0NEI0
names: Subcellular Location Annotation
messages: Nucleus

9615:NUCB1
gene id: 9615:NUCB1
uniprot id: A0A8C0PVG8
uniprot id: A0A8I3RP80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobindin family.
messages: Cytoplasm
messages: Secreted
messages: cis-Golgi network membrane

9615:GATAD1
gene id: 9615:GATAD1
uniprot id: A0A8C0N486
uniprot id: A0A8C0RJ31
uniprot id: A0A8I3NHV5
uniprot id: A0A8I3RZN0
names: Subcellular Location Annotation
messages: Nucleus

9615:NAPB
gene id: 9615:NAPB
uniprot id: A0A8C0P589
uniprot id: A0A8C0TIL3
uniprot id: A0A8I3PZJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9615:DDAH1
gene id: 9615:DDAH1
uniprot id: A0A8C0RLC5
uniprot id: A0A8I3MGE2
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9615:KLK2
gene id: 9615:KLK2
uniprot id: P09582
names: Function
names: Induction
names: Similarity
messages: Belongs to the peptidase S1 family. Kallikrein subfamily.
messages: By androgens.
messages: This serine protease is found in dog seminal plasma, its exact physiological function is not known.

9615:FOXS1
gene id: 9615:FOXS1
uniprot id: A0A8C0THU6
uniprot id: A0A8I3P6F2
names: Subcellular Location Annotation
messages: Nucleus

9615:DTX3L
gene id: 9615:DTX3L
uniprot id: A0A8C0THL0
uniprot id: A0A8I3PVC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9615:SEC61B
gene id: 9615:SEC61B
uniprot id: P60467
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:8107851). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (By similarity). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). Required for PKD1/Polycystin-1 biogenesis (By similarity).
messages: Endoplasmic reticulum membrane
messages: The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:10799540, PubMed:10860986, PubMed:8107851). The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact (By similarity). Interacts with TRAM1 (By similarity).

9615:LOC100685213
gene id: 9615:LOC100685213
uniprot id: P81255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
messages: Secreted

9615:ATP23
gene id: 9615:ATP23
uniprot id: A0A8I3N7V8
names: Similarity
messages: Belongs to the peptidase M76 family.

9615:PSMB3
gene id: 9615:PSMB3
uniprot id: A0A8C0M3N7
uniprot id: A0A8I3RXV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:LOC100687115
gene id: 9615:LOC100687115
uniprot id: A0A8C0Q2C0
uniprot id: A0A8I3N7Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9615:CNNM4
gene id: 9615:CNNM4
uniprot id: A0A8C0T231
uniprot id: A0A8C0T477
uniprot id: A0A8I3PEA1
uniprot id: A0A8I3PI07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9615:MAPK3
gene id: 9615:MAPK3
uniprot id: A0A8C0RUD1
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola

9615:DEFB128
gene id: 9615:DEFB128
uniprot id: Q30KS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:SERPINE1
gene id: 9615:SERPINE1
uniprot id: A0A8C0PBU3
uniprot id: A0A8I3MDS4
names: Similarity
messages: Belongs to the serpin family.

9615:KRT124
gene id: 9615:KRT124
uniprot id: A0A8P0TN42
names: Similarity
messages: Belongs to the intermediate filament family.

9615:FOXI3
gene id: 9615:FOXI3
uniprot id: B5RHS5
names: Disease Annotation
names: Function
names: Subcellular Location Annotation
messages: Defects in FOXI3 are the cause of canine ectodermal dysplasia (CED). CED is an autosomal semi-dominant trait characterized by missing or abnormally shaped teeth in addition to a hair coat that is sparse or absent. Heterozygous mutants are found in Mexican and Peruvian hairless dogs and in Chinese crested dogs. Homozygous mutants die during embryogenesis.
messages: Nucleus
messages: Possible transcriptional factor. May play a role in the development of the epithelium of hair and whisker placodes and that of teeth.

9615:ACP7
gene id: 9615:ACP7
uniprot id: A0A8C0NN32
uniprot id: A0A8I3MUC8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9615:NKRF
gene id: 9615:NKRF
uniprot id: A0A8C0SLH9
uniprot id: A0A8I3PLB9
names: Similarity
messages: Belongs to the CARF family.

9615:TMEM47
gene id: 9615:TMEM47
uniprot id: Q9XSV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TMEM47 family.
messages: Highly expressed in brain.
messages: Interacts with CTNNB1, CTNNA1, PRKCI, PARD6B (PubMed:26990309). Interacts with FYB1 (By similarity).
messages: Membrane
messages: Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B (PubMed:26990309). During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity).
messages: adherens junction

9615:ACTBL2
gene id: 9615:ACTBL2
uniprot id: A0A8C0PT64
uniprot id: A0A8I3Q739
names: Similarity
messages: Belongs to the actin family.

9615:SF3A1
gene id: 9615:SF3A1
uniprot id: A0A8C0TGA5
uniprot id: A0A8I3PDS4
names: Subcellular Location Annotation
messages: Nucleus

9615:RPL6
gene id: 9615:RPL6
uniprot id: A0A8C0TP42
uniprot id: F1Q424
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9615:CRH
gene id: 9615:CRH
uniprot id: A0A8C0NFE2
uniprot id: A0A8I3PCJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9615:EIF1AD
gene id: 9615:EIF1AD
uniprot id: A0A8C0NT14
uniprot id: A0A8I3S0Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9615:MYOD1
gene id: 9615:MYOD1
uniprot id: A0A8C0TH61
uniprot id: A0A8I3NJT4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9615:KPNB1
gene id: 9615:KPNB1
uniprot id: A0A8C0M352
uniprot id: A0A8I3NZP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

9615:FOXN3
gene id: 9615:FOXN3
uniprot id: A0A8C0LVT5
uniprot id: A0A8P0T9S0
names: Subcellular Location Annotation
messages: Nucleus

9615:DKC1
gene id: 9615:DKC1
uniprot id: A0A8C0PAY4
uniprot id: A0A8I3Q2L7
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9615:FMNL3
gene id: 9615:FMNL3
uniprot id: A0A8C0NRQ3
uniprot id: A0A8C0NUS3
uniprot id: A0A8C0Z5I5
uniprot id: A0A8I3P3Y2
uniprot id: A0A8I3P553
names: Similarity
messages: Belongs to the formin homology family.

9615:MELK
gene id: 9615:MELK
uniprot id: A0A8C0MM54
uniprot id: A0A8I3NCR5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9615:MFSD6
gene id: 9615:MFSD6
uniprot id: A0A8I3S539
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9615:CASP9
gene id: 9615:CASP9
uniprot id: A0A8C0Q619
uniprot id: Q45T68
names: Similarity
messages: Belongs to the peptidase C14A family.

9615:RNF7
gene id: 9615:RNF7
uniprot id: A0A8I3Q4K7
names: Similarity
messages: Belongs to the RING-box family.

9615:WEE1
gene id: 9615:WEE1
uniprot id: A0A8C0MJT1
uniprot id: A0A8I3NRX2
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

9615:VPS11
gene id: 9615:VPS11
uniprot id: A0A8C0MA69
uniprot id: A0A8I3MLR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9615:MRPL12
gene id: 9615:MRPL12
uniprot id: A0A8C0PKY3
uniprot id: A0A8I3NE78
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9615:PARP9
gene id: 9615:PARP9
uniprot id: A0A8P0NE46
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:SNX13
gene id: 9615:SNX13
uniprot id: A0A8I3N195
names: Similarity
messages: Belongs to the sorting nexin family.

9615:BRMS1L
gene id: 9615:BRMS1L
uniprot id: A0A8C0TIF0
uniprot id: A0A8I3RQR5
names: Subcellular Location Annotation
messages: Nucleus

9615:NOP58
gene id: 9615:NOP58
uniprot id: A0A8C0RNY9
uniprot id: A0A8P0SH28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9615:AQP10
gene id: 9615:AQP10
uniprot id: A0A8C0RW51
uniprot id: A0A8I3S111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:UBA3
gene id: 9615:UBA3
uniprot id: A0A8C0S5E2
uniprot id: A0A8C0S5Y5
uniprot id: A0A8I3NAK8
uniprot id: A0A8I3NEL0
uniprot id: A0A8I3NHJ7
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9615:LDB1
gene id: 9615:LDB1
uniprot id: A0A8C0PVD8
uniprot id: A0A8I3PGY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB family.
messages: Nucleus

9615:AQP4
gene id: 9615:AQP4
uniprot id: A0A8I3RX19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:TLE2
gene id: 9615:TLE2
uniprot id: A0A8P0NKG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9615:ICAM3
gene id: 9615:ICAM3
uniprot id: A0A8P0THL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9615:LOC100688969
gene id: 9615:LOC100688969
uniprot id: A0A8C0RRE8
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9615:XRN2
gene id: 9615:XRN2
uniprot id: A0A8C0P792
uniprot id: A0A8I3PU99
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9615:ITGA10
gene id: 9615:ITGA10
uniprot id: A0A8C0QEX0
uniprot id: A0A8I3RW71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:CACNA1D
gene id: 9615:CACNA1D
uniprot id: A0A8C0T2Q3
uniprot id: A0A8C0T2W3
uniprot id: A0A8C0T3X3
uniprot id: A0A8C0Z1I5
uniprot id: A0A8I3PVS0
uniprot id: A0A8I3PVT8
uniprot id: A0A8I3PW57
uniprot id: A0A8I3Q2Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9615:CKAP5
gene id: 9615:CKAP5
uniprot id: A0A8C0PKG0
uniprot id: A0A8I3QAG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

9615:ATP8A2
gene id: 9615:ATP8A2
uniprot id: A0A8I3P728
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:DTNB
gene id: 9615:DTNB
uniprot id: A0A8C0MBC5
uniprot id: A0A8I3PV08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9615:SGTA
gene id: 9615:SGTA
uniprot id: A0A8C0MQZ8
uniprot id: F6XMP7
names: Similarity
messages: Belongs to the SGT family.

9615:AREG
gene id: 9615:AREG
uniprot id: A0A8C0QJI3
uniprot id: A0A8I3N245
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:IP6K3
gene id: 9615:IP6K3
uniprot id: A0A8C0M6W6
uniprot id: A0A8I3PS77
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9615:FAM83E
gene id: 9615:FAM83E
uniprot id: A0A8C0Q551
uniprot id: A0A8I3MN62
names: Similarity
messages: Belongs to the FAM83 family.

9615:LSM4
gene id: 9615:LSM4
uniprot id: A0A8C0NM94
uniprot id: A0A8I3PGH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9615:UTP18
gene id: 9615:UTP18
uniprot id: A0A8C0N861
uniprot id: A0A8I3NXV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

9615:OR4P4
gene id: 9615:OR4P4
uniprot id: A0A8C0MDC9
uniprot id: A0A8I3NHW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:KLRA1
gene id: 9615:KLRA1
uniprot id: A0A8C0SDH1
uniprot id: Q863K3
names: Subcellular Location Annotation
messages: Membrane

9615:TMEM41B
gene id: 9615:TMEM41B
uniprot id: A0A8C0RER8
uniprot id: A0A8I3P070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9615:WLS
gene id: 9615:WLS
uniprot id: A0A8C0NA19
uniprot id: A0A8I3P126
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9615:CRYBA1
gene id: 9615:CRYBA1
uniprot id: A0A8C0N1A3
uniprot id: A2IBY9
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9615:PMPCB
gene id: 9615:PMPCB
uniprot id: A0A8C0SQP4
uniprot id: A0A8I3NYF1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Mitochondrion matrix

9615:TUBB1
gene id: 9615:TUBB1
uniprot id: A0A8C0T7N2
uniprot id: A0A8I3NIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:EAF1
gene id: 9615:EAF1
uniprot id: A0A8C0T2F0
names: Similarity
messages: Belongs to the EAF family.

9615:AP3M1
gene id: 9615:AP3M1
uniprot id: A0A8C0Q4Z8
uniprot id: A0A8P0P0U5
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

9615:ZNF18
gene id: 9615:ZNF18
uniprot id: A0A8C0T5L1
uniprot id: A0A8I3N5H1
names: Subcellular Location Annotation
messages: Nucleus

9615:NOP56
gene id: 9615:NOP56
uniprot id: A0A8C0MD96
uniprot id: A0A8P0N946
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9615:KCNF1
gene id: 9615:KCNF1
uniprot id: A0A8C0MET0
names: Subcellular Location Annotation
messages: Membrane

9615:TBX5
gene id: 9615:TBX5
uniprot id: A0A8C0PLE5
uniprot id: A0A8I3PS67
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:NOS3
gene id: 9615:NOS3
uniprot id: A0A8C0Q3E0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

9615:SLC39A7
gene id: 9615:SLC39A7
uniprot id: Q5TJF6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
messages: Endoplasmic reticulum membrane
messages: Methylation at some His residue by METTL9 leads to reduced zinc-binding.
messages: Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). Has an essential role in B cell development and is required for proper B cell receptor signaling.
messages: cis-Golgi network membrane

9615:NAA35
gene id: 9615:NAA35
uniprot id: A0A8I3MQH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9615:SNRPB
gene id: 9615:SNRPB
uniprot id: A0A8C0Z1I9
uniprot id: A0A8I3P5Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9615:COQ6
gene id: 9615:COQ6
uniprot id: A0A8C0P1Y4
uniprot id: A0A8I3NH66
uniprot id: A0A8I3NR78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

9615:RECQL5
gene id: 9615:RECQL5
uniprot id: A0A8C0MBI7
uniprot id: A0A8P0SAE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9615:PPIC
gene id: 9615:PPIC
uniprot id: A0A8P0NP26
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9615:MMP3
gene id: 9615:MMP3
uniprot id: Q6Y4Q5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 4 Ca(2+) ions per subunit.
messages: Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Acts also intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. In addition, plays a role in immune response and possesses antiviral activity against various viruses. Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

9615:TPRKB
gene id: 9615:TPRKB
uniprot id: A0A8C0SRI7
uniprot id: A0A8I3P6S8
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9615:CDKL4
gene id: 9615:CDKL4
uniprot id: A0A8C0TRE9
uniprot id: A0A8I3PF24
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:PA2G4
gene id: 9615:PA2G4
uniprot id: A0A8C0Q8X0
uniprot id: A0A8I3MYE2
names: Similarity
messages: Belongs to the peptidase M24 family.

9615:MCOLN2
gene id: 9615:MCOLN2
uniprot id: A0A8C0NCC2
uniprot id: A0A8I3MYU1
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9615:PRAF2
gene id: 9615:PRAF2
uniprot id: A0A8C0S9V3
uniprot id: A0A8I3Q651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9615:ARHGAP26
gene id: 9615:ARHGAP26
uniprot id: A0A8C0M1N6
uniprot id: A0A8C0MBC2
uniprot id: A0A8C0MBG2
uniprot id: A0A8I3P6T2
uniprot id: A0A8I3S3A5
uniprot id: A0A8I3S3E6
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9615:POFUT1
gene id: 9615:POFUT1
uniprot id: Q00P48
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

9615:EIF2AK3
gene id: 9615:EIF2AK3
uniprot id: A0A8C0SMV4
uniprot id: A0A8P0NA05
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9615:TAS1R2
gene id: 9615:TAS1R2
uniprot id: Q49HI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
messages: Cell membrane
messages: Forms heterodimers with TAS1R3.
messages: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity).

9615:TAGLN3
gene id: 9615:TAGLN3
uniprot id: A0A8C0TIB2
uniprot id: A0A8I3PZB6
names: Similarity
messages: Belongs to the calponin family.

9615:SMARCB1
gene id: 9615:SMARCB1
uniprot id: A0A8C0PI49
uniprot id: A0A8I3PW02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

9615:CCHCR1
gene id: 9615:CCHCR1
uniprot id: A0A8P0N3Q4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9615:LOC481709
gene id: 9615:LOC481709
uniprot id: A0A8C0MBD5
uniprot id: A0A8P0N3Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Nucleus

9615:BPNT2
gene id: 9615:BPNT2
uniprot id: A0A8C0NQZ6
uniprot id: A0A8I3PTD3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9615:STXBP5
gene id: 9615:STXBP5
uniprot id: A0A8C0SHF3
uniprot id: A0A8C0SHN8
uniprot id: A0A8P0S6G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9615:GANAB
gene id: 9615:GANAB
uniprot id: A0A8C0MBF0
uniprot id: A0A8C0TAI1
uniprot id: A0A8P0P6M6
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9615:GRIK2
gene id: 9615:GRIK2
uniprot id: A0A8I3N665
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9615:PKD2L2
gene id: 9615:PKD2L2
uniprot id: A0A8I3P3A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

9615:IDS
gene id: 9615:IDS
uniprot id: A0A8C0MNW8
uniprot id: Q32KH3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:TCN1
gene id: 9615:TCN1
uniprot id: A0A8C0PRM0
uniprot id: A0A8P0SF52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9615:MACF1
gene id: 9615:MACF1
uniprot id: A0A8C0P0L7
names: Subcellular Location Annotation
messages: cytoskeleton

9615:SLC25A40
gene id: 9615:SLC25A40
uniprot id: A0A8C0MK74
uniprot id: A0A8I3N8S5
uniprot id: A0A8I3NBW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9615:SF3B6
gene id: 9615:SF3B6
uniprot id: A0A8C0QGX1
uniprot id: A0A8I3PC35
names: Subcellular Location Annotation
messages: Nucleus

9615:SLC44A4
gene id: 9615:SLC44A4
uniprot id: A0A8P0TNH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9615:OR5AS1
gene id: 9615:OR5AS1
uniprot id: A0A8C0RC98
uniprot id: A0A8I3MZI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:GPR61
gene id: 9615:GPR61
uniprot id: A0A8C0NEQ8
uniprot id: A0A8I3MME0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:TUBB4A
gene id: 9615:TUBB4A
uniprot id: A0A8C0NY69
uniprot id: A0A8I3NFI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:PUS10
gene id: 9615:PUS10
uniprot id: A0A8P0S8R3
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

9615:FSCN2
gene id: 9615:FSCN2
uniprot id: A0A8C0Q2X3
uniprot id: A0A8P0N8C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9615:STOML2
gene id: 9615:STOML2
uniprot id: A0A8C0NHE2
uniprot id: A0A8I3N1K9
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9615:FAM83C
gene id: 9615:FAM83C
uniprot id: A0A8C0QF06
uniprot id: A0A8P0NR62
names: Similarity
messages: Belongs to the FAM83 family.

9615:OLFM3
gene id: 9615:OLFM3
uniprot id: A0A8C0P411
uniprot id: A0A8C0PVH9
uniprot id: A0A8I3NB44
uniprot id: A0A8I3NKF9
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9615:GAPDHS
gene id: 9615:GAPDHS
uniprot id: A0A8C0PLU8
uniprot id: A0A8I3MKW3
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9615:LOC100683724
gene id: 9615:LOC100683724
uniprot id: A0A8C0MA31
uniprot id: A0A8I3NPU2
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9615:UBE2L6
gene id: 9615:UBE2L6
uniprot id: A0A8C0SL13
uniprot id: A0A8I3PAX4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:SRD5A3
gene id: 9615:SRD5A3
uniprot id: A0A8C0SRL2
uniprot id: A0A8I3NC01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9615:AK8
gene id: 9615:AK8
uniprot id: A0A8C0P0G9
uniprot id: A0A8I3NQB2
names: Similarity
messages: Belongs to the adenylate kinase family.

9615:KCNJ8
gene id: 9615:KCNJ8
uniprot id: A0A8C0P7N1
uniprot id: A0A8I3NUB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9615:C1S
gene id: 9615:C1S
uniprot id: A0A8C0TNV8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:EDEM2
gene id: 9615:EDEM2
uniprot id: A0A8C0P852
uniprot id: A0A8I3P7V3
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9615:OPA3
gene id: 9615:OPA3
uniprot id: A0A8I3RTX5
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

9615:SIX6
gene id: 9615:SIX6
uniprot id: A0A8C0QBD7
uniprot id: A0A8I3PIU9
names: Subcellular Location Annotation
messages: Nucleus

9615:RBBP5
gene id: 9615:RBBP5
uniprot id: A0A8C0MY00
uniprot id: A0A8C0SYR7
uniprot id: A0A8I3PRI4
names: Subcellular Location Annotation
messages: Nucleus

9615:NDUFB4
gene id: 9615:NDUFB4
uniprot id: A0A8C0Z2F3
uniprot id: A0A8I3P7K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:APRT
gene id: 9615:APRT
uniprot id: A0A8C0S3M2
uniprot id: A0A8I3MH54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

9615:ZDHHC16
gene id: 9615:ZDHHC16
uniprot id: A0A8C0P650
uniprot id: A0A8C0PAF9
uniprot id: A0A8I3QJD8
uniprot id: A0A8I3QSH1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:CUTC
gene id: 9615:CUTC
uniprot id: A0A8C0P777
uniprot id: A0A8C0T1P0
uniprot id: A0A8I3QD47
uniprot id: A0A8I3QQ18
uniprot id: A0A8I3QVE5
names: Similarity
messages: Belongs to the CutC family.

9615:DNASE1L3
gene id: 9615:DNASE1L3
uniprot id: A0A8C0QQM4
uniprot id: A0A8I3P4R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Nucleus envelope
messages: Zymogen granule

9615:ZNF687
gene id: 9615:ZNF687
uniprot id: A0A8C0MLL2
uniprot id: A0A8C0MS87
uniprot id: A0A8I3PKD1
uniprot id: A0A8I3PRI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:OR6C69G
gene id: 9615:OR6C69G
uniprot id: A0A8C0SYZ0
uniprot id: A0A8I3QA69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:POLR3D
gene id: 9615:POLR3D
uniprot id: A0A8C0NTC2
uniprot id: A0A8I3PPE4
names: Subcellular Location Annotation
messages: Nucleus

9615:FAM25A
gene id: 9615:FAM25A
uniprot id: A0A8C0LXH7
uniprot id: A0A8P0TIY3
names: Similarity
messages: Belongs to the FAM25 family.

9615:ZNF215
gene id: 9615:ZNF215
uniprot id: A0A8I3NPF2
names: Subcellular Location Annotation
messages: Nucleus

9615:TMEM126B
gene id: 9615:TMEM126B
uniprot id: A0A8C0TI18
uniprot id: A0A8P0SA56
names: Subcellular Location Annotation
messages: Membrane

9615:CBLB
gene id: 9615:CBLB
uniprot id: A0A8I3PCV8
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9615:LPAR5
gene id: 9615:LPAR5
uniprot id: A0A8C0T120
uniprot id: A0A8I3SBJ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:QARS1
gene id: 9615:QARS1
uniprot id: A0A8C0TDF6
uniprot id: A0A8P0NDV0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:GLYAT
gene id: 9615:GLYAT
uniprot id: A0A8C0NWV5
uniprot id: A0A8I3PBY9
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9615:PPAN
gene id: 9615:PPAN
uniprot id: A0A8C0PFA1
uniprot id: A0A8I3S0L9
names: Subcellular Location Annotation
messages: nucleolus

9615:HMBS
gene id: 9615:HMBS
uniprot id: A0A8C0TCQ7
uniprot id: A0A8C0TFA4
uniprot id: A0A8I3RP95
names: Similarity
messages: Belongs to the HMBS family.

9615:CAVIN4
gene id: 9615:CAVIN4
uniprot id: A0A8C0NP85
uniprot id: A0A8I3N7B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

9615:CPNE5
gene id: 9615:CPNE5
uniprot id: A0A8I3NP56
uniprot id: A0A8I3RXB0
names: Similarity
messages: Belongs to the copine family.

9615:GNB3
gene id: 9615:GNB3
uniprot id: A9UHL9
uniprot id: P79147
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2 (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: perinuclear region

9615:EEF1AKMT1
gene id: 9615:EEF1AKMT1
uniprot id: A0A8C0Z5V1
uniprot id: A0A8I3PHI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9615:NFASC
gene id: 9615:NFASC
uniprot id: A0A8C0MZN5
uniprot id: A0A8C0RH49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9615:SAG
gene id: 9615:SAG
uniprot id: Q28281
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arrestin family.
messages: Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
messages: Defects in SAG may be the cause of generalized progressive retinal atrophy (gPRA) in some breeds.
messages: Membrane
messages: Monomer. Homodimer. Homotetramer. Interacts with RHO (via the phosphorylated C-terminus).
messages: The C-terminus interferes with binding to non-phosphorylated RHO. Interaction with phosphorylated RHO triggers displacement of the C-terminus and leads to a conformation change that mediates high-affinity RHO binding.
messages: photoreceptor outer segment

9615:AQP7
gene id: 9615:AQP7
uniprot id: A0A8C0QPW7
uniprot id: A0A8C0RE45
uniprot id: A0A8I3PAE2
uniprot id: A0A8I3PFQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:AP1S1
gene id: 9615:AP1S1
uniprot id: A0A8C0P5V2
uniprot id: A0A8I3MGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9615:ITGAX
gene id: 9615:ITGAX
uniprot id: A0A8C0M955
uniprot id: A0A8I3NEY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9615:ZFYVE26
gene id: 9615:ZFYVE26
uniprot id: A0A8C0NEE1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.
messages: Midbody
messages: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

9615:PDE4B
gene id: 9615:PDE4B
uniprot id: A0A8C0M3Z2
uniprot id: A0A8C0M947
uniprot id: A0A8C0QIS1
uniprot id: A0A8C0QIV5
uniprot id: A0A8I3PZX6
uniprot id: A0A8I3Q1G8
uniprot id: A0A8I3SBV2
uniprot id: A0A8I3SBZ4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:HIGD1B
gene id: 9615:HIGD1B
uniprot id: A0A8C0M3H0
uniprot id: A0A8C0SJJ0
uniprot id: A0A8I3RTR9
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9615:MYADML2
gene id: 9615:MYADML2
uniprot id: A0A8P0SBC6
names: Subcellular Location Annotation
messages: Membrane

9615:KRT17
gene id: 9615:KRT17
uniprot id: A0A8C0S7D0
names: Similarity
messages: Belongs to the intermediate filament family.

9615:FABP1
gene id: 9615:FABP1
uniprot id: A0A8C0SNT4
uniprot id: A0A8I3ND57
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9615:FXYD2
gene id: 9615:FXYD2
uniprot id: A0A8C0MSH3
uniprot id: A0A8I3MV55
names: Similarity
messages: Belongs to the FXYD family.

9615:TNNI3
gene id: 9615:TNNI3
uniprot id: Q8MKD5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the troponin I family.
messages: Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1 (By similarity).
messages: Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-32. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylated at Ser-43 and Ser-45 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity).
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9615:KAT2A
gene id: 9615:KAT2A
uniprot id: A0A8C0M065
uniprot id: A0A8I3NA81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: centrosome

9615:CENPT
gene id: 9615:CENPT
uniprot id: A0A8C0NTF8
uniprot id: A0A8I3MYA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

9615:BCDIN3D
gene id: 9615:BCDIN3D
uniprot id: A0A8C0PTV7
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9615:BCAS2
gene id: 9615:BCAS2
uniprot id: A0A8C0QMQ4
uniprot id: A0A8I3PM73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

9615:LOC476006
gene id: 9615:LOC476006
uniprot id: A0A8C0S6P0
uniprot id: A0A8I3NDR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

9615:CYP4X1
gene id: 9615:CYP4X1
uniprot id: A0A8I3P954
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:RNF114
gene id: 9615:RNF114
uniprot id: A0A8C0PL13
uniprot id: A0A8I3PS94
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

9615:SLC43A3
gene id: 9615:SLC43A3
uniprot id: A0A8C0SMW5
uniprot id: A0A8I3S534
names: Subcellular Location Annotation
messages: Membrane

9615:RPL31
gene id: 9615:RPL31
uniprot id: A0A8C0RQC2
uniprot id: E2R8G3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9615:ATP6V1E2
gene id: 9615:ATP6V1E2
uniprot id: A0A8C0RHM0
uniprot id: A0A8P0PN00
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9615:MYO3B
gene id: 9615:MYO3B
uniprot id: A0A8I3PV92
uniprot id: A0A8I3S588
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

9615:COX6A2
gene id: 9615:COX6A2
uniprot id: A0A8C0RC68
uniprot id: A0A8I3NIL8
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6A family.

9615:TECPR1
gene id: 9615:TECPR1
uniprot id: A0A8C0SE49
uniprot id: A0A8P0PAG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TECPR1 family.
messages: Lysosome membrane
messages: autophagosome membrane

9615:PWWP3B
gene id: 9615:PWWP3B
uniprot id: A0A8I3NV87
names: Similarity
messages: Belongs to the PWWP3A family.

9615:RPLP0
gene id: 9615:RPLP0
uniprot id: A0A8C0T9H8
uniprot id: A0A8I3QJZ3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9615:GALK2
gene id: 9615:GALK2
uniprot id: A0A8C0MLJ8
uniprot id: A0A8C0MVA7
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9615:PDIA6
gene id: 9615:PDIA6
uniprot id: A0A8C0MEJ6
uniprot id: A0A8I3Q0F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

9615:APLP1
gene id: 9615:APLP1
uniprot id: A0A8C0T6E9
uniprot id: A0A8I3RPF3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:TYMS
gene id: 9615:TYMS
uniprot id: A0A8C0PYK6
uniprot id: A0A8I3RRU2
names: Similarity
messages: Belongs to the thymidylate synthase family.

9615:PDRG1
gene id: 9615:PDRG1
uniprot id: A0A8C0MZZ5
uniprot id: A0A8I3PB75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9615:IGF2BP3
gene id: 9615:IGF2BP3
uniprot id: A0A8C0QDI8
uniprot id: A0A8I3NBD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule

9615:LOC100856086
gene id: 9615:LOC100856086
uniprot id: A0A8P0TRH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tigger transposable element derived protein family.
messages: Nucleus

9615:KHDC4
gene id: 9615:KHDC4
uniprot id: A0A8C0RUJ0
uniprot id: A0A8I3NI99
names: Similarity
messages: Belongs to the KHDC4 family.

9615:TEKT3
gene id: 9615:TEKT3
uniprot id: A0A8C0PPL5
uniprot id: A0A8P0SM29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9615:LOC490387
gene id: 9615:LOC490387
uniprot id: A0A8C0SBM0
uniprot id: A0A8P0NHK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9615:ACTR1A
gene id: 9615:ACTR1A
uniprot id: P61162
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP1 subfamily.
messages: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
messages: Interacts with BCCIP.
messages: cell cortex
messages: centrosome
messages: cytoskeleton

9615:TNNT3
gene id: 9615:TNNT3
uniprot id: A0A8C0TTU2
uniprot id: A0A8C0Z6D9
uniprot id: A0A8I3N599
uniprot id: A0A8I3N9X8
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9615:NHSL2
gene id: 9615:NHSL2
uniprot id: A0A8C0N326
uniprot id: A0A8I3S190
names: Similarity
messages: Belongs to the NHS family.

9615:ZACN
gene id: 9615:ZACN
uniprot id: Q866Y9
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Glycosylated.
messages: The mouse and rat orthologous proteins do not exist.
messages: Zinc-activated ligand-gated ion channel.

9615:LOC608051
gene id: 9615:LOC608051
uniprot id: A0A8C0PIB7
uniprot id: A0A8P0SSR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9615:IL18
gene id: 9615:IL18
uniprot id: Q9XSR0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.

9615:CUTA
gene id: 9615:CUTA
uniprot id: A0A8C0NDR4
uniprot id: A0A8C0QLL2
uniprot id: A0A8I3PHH4
uniprot id: A0A8I3PMV7
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9615:ATL2
gene id: 9615:ATL2
uniprot id: A0A8C0MKE9
uniprot id: A0A8C0TT54
uniprot id: A0A8I3S1U0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9615:POLB
gene id: 9615:POLB
uniprot id: A0A8C0QAM8
uniprot id: A0A8I3NDB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

9615:SPICE1
gene id: 9615:SPICE1
uniprot id: A0A8C0PFW6
uniprot id: A0A8I3QLX4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

9615:WAS
gene id: 9615:WAS
uniprot id: A0A8I3PLH5
names: Subcellular Location Annotation
messages: Nucleus

9615:HRH1
gene id: 9615:HRH1
uniprot id: A0A8C0Z543
uniprot id: A0A8I3MSX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:CERS5
gene id: 9615:CERS5
uniprot id: A0A8I3P037
uniprot id: A0A8I3P1Y0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9615:RGR
gene id: 9615:RGR
uniprot id: A0A8C0M006
names: Subcellular Location Annotation
messages: Membrane

9615:TMEM150A
gene id: 9615:TMEM150A
uniprot id: A0A8C0MVM8
uniprot id: A0A8C0N1B9
uniprot id: A0A8I3NIL0
uniprot id: A0A8I3NV79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Membrane

9615:AP3S2
gene id: 9615:AP3S2
uniprot id: A0A8C0LZK8
uniprot id: A0A8I3MH13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9615:CDC73
gene id: 9615:CDC73
uniprot id: A0A8C0S807
uniprot id: A2SXS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

9615:HTR1D
gene id: 9615:HTR1D
uniprot id: P11614
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
messages: Homodimer. Heterodimer with HTR1B (By similarity).

9615:IDH3B
gene id: 9615:IDH3B
uniprot id: A0A8C0SZ51
uniprot id: A0A8C0T195
uniprot id: A0A8I3S238
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9615:SLC4A1
gene id: 9615:SLC4A1
uniprot id: Q2Z1P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
messages: Membrane

9615:TSPAN5
gene id: 9615:TSPAN5
uniprot id: A0A8C0TAW6
uniprot id: A0A8I3PVZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:SDHAF2
gene id: 9615:SDHAF2
uniprot id: A0A8C0PAQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9615:SLC25A19
gene id: 9615:SLC25A19
uniprot id: A0A8C0QCZ7
uniprot id: A0A8I3PW08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:PDE5A
gene id: 9615:PDE5A
uniprot id: O77746
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 1 Mg(2+) ions per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Binds magnesium less tightly than zinc.
messages: Binds 1 Zn(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Tightly binds zinc.
messages: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B.
messages: Cytoplasm
messages: Inhibited by zaprinast.
messages: Isoform PDE5A1 and isoform PDE5A2 are highly expressed in the cerebellum, hippocampus, retina, lung, heart, spleen, and thoracic artery. Isoform PDE5A1, but not isoform PDE5A2, is also abundantly expressed in the pylorus.
messages: Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation.
messages: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
messages: cGMP-binding to the allosteric sites is stimulated by 3-isobutyl-1-methylxanthine (IBMX).
messages: cytosol

9615:ARHGEF12
gene id: 9615:ARHGEF12
uniprot id: A0A8C0LY91
uniprot id: A0A8I3NH44
uniprot id: A0A8I3NID3
uniprot id: A0A8I3NRY3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9615:UMPS
gene id: 9615:UMPS
uniprot id: A0A8C0Z612
uniprot id: A0A8I3Q010
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9615:INHBA
gene id: 9615:INHBA
uniprot id: A0A8C0S0W6
uniprot id: A0A8I3P2Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9615:SIX1
gene id: 9615:SIX1
uniprot id: A0A8C0PTN2
uniprot id: J9P3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

9615:DLGAP4
gene id: 9615:DLGAP4
uniprot id: A0A8C0SBK2
uniprot id: A0A8C0YWB0
uniprot id: A0A8I3PW67
names: Similarity
messages: Belongs to the SAPAP family.

9615:CCNL2
gene id: 9615:CCNL2
uniprot id: A0A8C0LWL9
uniprot id: A0A8I3PXG8
names: Similarity
messages: Belongs to the cyclin family.

9615:DPP3
gene id: 9615:DPP3
uniprot id: A0A8C0NJ31
uniprot id: A0A8P0SH85
uniprot id: A0A8P0TSG1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

9615:GPR1
gene id: 9615:GPR1
uniprot id: A0A8C0TXR1
uniprot id: A0A8I3P634
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9615:STRN3
gene id: 9615:STRN3
uniprot id: A0A8C0N6A8
uniprot id: A0A8C0SAQ0
uniprot id: A0A8C0SBT1
uniprot id: A0A8I3N628
uniprot id: A0A8I3NGI8
uniprot id: A0A8P0PCG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9615:ELP3
gene id: 9615:ELP3
uniprot id: A0A8C0PJ98
uniprot id: A0A8I3MZN4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9615:IL1A
gene id: 9615:IL1A
uniprot id: A0A8C0SHI9
uniprot id: A0A8I3NDD2
uniprot id: A0T125
uniprot id: O46612
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated within its nuclear localization sequence, which impacts subcellular localization.
messages: Belongs to the IL-1 family.
messages: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
messages: Cytoplasm
messages: Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.
messages: Nucleus
messages: Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.
messages: Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.
messages: Secreted
messages: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

9615:KRT31
gene id: 9615:KRT31
uniprot id: A0A8C0SD00
uniprot id: A0A8I3NCT2
names: Similarity
messages: Belongs to the intermediate filament family.

9615:PLD3
gene id: 9615:PLD3
uniprot id: A0A8C0SB92
uniprot id: A0A8I3MMY6
names: Similarity
messages: Belongs to the phospholipase D family.

9615:UXT
gene id: 9615:UXT
uniprot id: A0A8C0T2G7
uniprot id: A0A8P0SJR5
names: Similarity
messages: Belongs to the UXT family.

9615:TGFB3
gene id: 9615:TGFB3
uniprot id: A0A8C0SQX7
uniprot id: A0A8I3S1P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9615:OR10H1
gene id: 9615:OR10H1
uniprot id: A0A8I3S1I5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ENO2
gene id: 9615:ENO2
uniprot id: A0A8C0RQK5
uniprot id: A0A8I3S5Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9615:LOC480601
gene id: 9615:LOC480601
uniprot id: A0A8I3NA82
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9615:VPS26C
gene id: 9615:VPS26C
uniprot id: A0A8C0T9X7
uniprot id: A0A8I3SBK8
names: Similarity
messages: Belongs to the VPS26 family.

9615:IZUMO3
gene id: 9615:IZUMO3
uniprot id: A0A8C0Q2J6
uniprot id: A0A8I3NR97
names: Similarity
messages: Belongs to the Izumo family.

9615:CCT7
gene id: 9615:CCT7
uniprot id: A0A8C0SV37
uniprot id: A0A8I3S301
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9615:RETREG1
gene id: 9615:RETREG1
uniprot id: A0A0K1MBN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9615:RAD23A
gene id: 9615:RAD23A
uniprot id: A0A8C0NPF5
uniprot id: A0A8I3NT37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9615:CYP2A13
gene id: 9615:CYP2A13
uniprot id: Q307K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:RPL10A
gene id: 9615:RPL10A
uniprot id: A0A8C0SRI0
uniprot id: A0A8I3MZL8
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9615:SEMA3C
gene id: 9615:SEMA3C
uniprot id: A0A8C0MSG3
uniprot id: A0A8I3PRC1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:PNLDC1
gene id: 9615:PNLDC1
uniprot id: A0A8C0TM72
uniprot id: A0A8P0S6N9
names: Similarity
messages: Belongs to the CAF1 family.

9615:MTFP1
gene id: 9615:MTFP1
uniprot id: A0A8C0P4N2
uniprot id: A0A8I3P6R9
names: Similarity
messages: Belongs to the MTFP1 family.

9615:FITM1
gene id: 9615:FITM1
uniprot id: A0A8C0N1D3
uniprot id: A0A8I3MXT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

9615:HSPB7
gene id: 9615:HSPB7
uniprot id: A0A8I3MPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9615:DRC1
gene id: 9615:DRC1
uniprot id: A0A8I3Q2U0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC1 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: cilium axoneme
messages: flagellum axoneme

9615:PCNX3
gene id: 9615:PCNX3
uniprot id: A0A8C0NDS8
uniprot id: A0A8I3P9Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9615:TMED10
gene id: 9615:TMED10
uniprot id: A0A8C0RLR6
uniprot id: A0A8I3NRF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:PRF1
gene id: 9615:PRF1
uniprot id: C5IY80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9615:SORD
gene id: 9615:SORD
uniprot id: A0A8C0NKQ6
uniprot id: A0A8I3QI05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 1 or 2 Zn(2+) ions per subunit.
messages: Homotetramer.
messages: Mitochondrion membrane
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
messages: flagellum

9615:KRT35
gene id: 9615:KRT35
uniprot id: A0A8C0RN42
uniprot id: A0A8I3NDC0
names: Similarity
messages: Belongs to the intermediate filament family.

9615:OR13L2
gene id: 9615:OR13L2
uniprot id: A0A8P0SP95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SLC39A2
gene id: 9615:SLC39A2
uniprot id: A0A8C0ML99
uniprot id: A0A8I3PWH1
names: Subcellular Location Annotation
messages: Membrane

9615:ASB8
gene id: 9615:ASB8
uniprot id: A0A8C0PN26
uniprot id: A0A8I3PKA1
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9615:FAM229A
gene id: 9615:FAM229A
uniprot id: A0A8I3MTV1
names: Similarity
messages: Belongs to the FAM229 family.

9615:NIPA2
gene id: 9615:NIPA2
uniprot id: A0A8C0MIY4
uniprot id: A0A8C0MJ14
uniprot id: A0A8I3NZA7
uniprot id: A0A8I3RZ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9615:RNASE4
gene id: 9615:RNASE4
uniprot id: W0UVG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9615:CASP2
gene id: 9615:CASP2
uniprot id: A0A5F4CTZ8
uniprot id: A0A8C0MZD7
uniprot id: A0A8I3P463
names: Similarity
messages: Belongs to the peptidase C14A family.

9615:LOC611565
gene id: 9615:LOC611565
uniprot id: A0A8I3PGN1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MEIS2
gene id: 9615:MEIS2
uniprot id: A0A8C0PKC6
uniprot id: A0A8C0TP36
uniprot id: A0A8I3PXW8
uniprot id: A0A8I3PY10
uniprot id: A0A8I3PY27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9615:POLR2H
gene id: 9615:POLR2H
uniprot id: A0A8P0T3V0
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9615:GART
gene id: 9615:GART
uniprot id: A0A8C0Z741
uniprot id: A0A8I3PRU8
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

9615:MED8
gene id: 9615:MED8
uniprot id: A0A8C0MW17
uniprot id: A0A8I3PEC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:TMEM175
gene id: 9615:TMEM175
uniprot id: A0A8I3MY87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

9615:OTC
gene id: 9615:OTC
uniprot id: A0A8C0N9Z3
uniprot id: A0A8I3S5H5
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9615:XRCC5
gene id: 9615:XRCC5
uniprot id: A0A286T5F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus

9615:DGCR2
gene id: 9615:DGCR2
uniprot id: A0A8C0PCH5
uniprot id: A0A8C0T2I1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TRMO
gene id: 9615:TRMO
uniprot id: A0A8C0T0A4
uniprot id: A0A8I3RY66
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9615:CNPY2
gene id: 9615:CNPY2
uniprot id: A0A8C0NGE4
uniprot id: A0A8I3RVQ5
names: Similarity
messages: Belongs to the canopy family.

9615:INSIG2
gene id: 9615:INSIG2
uniprot id: A0A8C0NZL6
uniprot id: A0A8I3MQT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9615:CPN1
gene id: 9615:CPN1
uniprot id: A0A8P0SEL5
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:CHAC2
gene id: 9615:CHAC2
uniprot id: A0A8C0PJI0
uniprot id: A0A8I3N3M8
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9615:CYB561A3
gene id: 9615:CYB561A3
uniprot id: A0A8C0P773
uniprot id: A0A8P0TPA6
names: Subcellular Location Annotation
messages: Membrane

9615:GMFB
gene id: 9615:GMFB
uniprot id: A0A8C0M1Q3
uniprot id: A0A8C0Q0Q7
uniprot id: A0A8I3MTV9
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9615:SPG21
gene id: 9615:SPG21
uniprot id: A0A8C0NRQ0
uniprot id: A0A8I3PLL7
names: Function
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9615:MYBL1
gene id: 9615:MYBL1
uniprot id: A0A8C0RIX7
names: Subcellular Location Annotation
messages: Nucleus

9615:F3
gene id: 9615:F3
uniprot id: A0A8C0NAL8
uniprot id: Q4W6L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9615:GRINA
gene id: 9615:GRINA
uniprot id: A0A8C0PNV7
uniprot id: A0A8P0N4L6
names: Subcellular Location Annotation
messages: Membrane

9615:APOA2
gene id: 9615:APOA2
uniprot id: E2RAK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A2 family.
messages: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
messages: Monomer. Interacts with NAXE and NDRG1 (By similarity).
messages: Plasma.
messages: Secreted

9615:CEP44
gene id: 9615:CEP44
uniprot id: A0A8C0TD67
uniprot id: A0A8P0SD40
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9615:SCN10A
gene id: 9615:SCN10A
uniprot id: O46669
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
messages: Cell membrane
messages: Expressed in nodose ganglia, but not in cortex, hippocampus, cerebellum, liver, heart and skeletal muscle.
messages: Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 825) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.
messages: Phosphorylation at Ser-1458 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
messages: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity).
messages: The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.
messages: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
messages: Ubiquitinated by NEDD4L; which promotes its endocytosis.

9615:COX8A
gene id: 9615:COX8A
uniprot id: A0A8C0SNZ0
uniprot id: A0A8I3QBW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9615:NEU3
gene id: 9615:NEU3
uniprot id: A0A8I3MQZ3
uniprot id: A0A8P0N835
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9615:ALCAM
gene id: 9615:ALCAM
uniprot id: A0A8C0T4H7
uniprot id: A0A8I3PIH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9615:OR5P4
gene id: 9615:OR5P4
uniprot id: A0A8C0RIA8
uniprot id: A0A8I3NGY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:GCG
gene id: 9615:GCG
uniprot id: P29794
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glucagon family.
messages: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain.
messages: Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion (By similarity).
messages: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
messages: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
messages: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.
messages: Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas (By similarity).
messages: Secreted
messages: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.
messages: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.

9615:CPA5
gene id: 9615:CPA5
uniprot id: A0A8C0PLI8
uniprot id: A0A8I3NVC6
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:MDC1
gene id: 9615:MDC1
uniprot id: A0A8I3N6U4
names: Function
messages: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

9615:NLRP12
gene id: 9615:NLRP12
uniprot id: A0A8C0RUY7
uniprot id: A0A8I3N819
uniprot id: A0A8P0S8J8
names: Similarity
messages: Belongs to the NLRP family.

9615:SGSH
gene id: 9615:SGSH
uniprot id: A0A8C0PTX5
uniprot id: Q9GJU7
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:NSUN4
gene id: 9615:NSUN4
uniprot id: A0A8I3P7P3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9615:EFHC1
gene id: 9615:EFHC1
uniprot id: A0A8P0SPD7
names: Subcellular Location Annotation
messages: cilium axoneme

9615:C4BPB
gene id: 9615:C4BPB
uniprot id: A0A8P0NQ13
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:EXOC6B
gene id: 9615:EXOC6B
uniprot id: A0A8C0PFZ9
uniprot id: A0A8C0RS33
uniprot id: A0A8I3P546
uniprot id: A0A8I3PGI4
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9615:TEC
gene id: 9615:TEC
uniprot id: A0A8C0S3M6
uniprot id: A0A8I3NBM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:LOC486100
gene id: 9615:LOC486100
uniprot id: A0A8C0SYC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.

9615:AGPAT2
gene id: 9615:AGPAT2
uniprot id: A0A8I3MT53
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9615:SDHC
gene id: 9615:SDHC
uniprot id: A0A8I3QQW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9615:CPLX3
gene id: 9615:CPLX3
uniprot id: A0A8C0MYD4
uniprot id: A0A8I3P5K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9615:ARVCF
gene id: 9615:ARVCF
uniprot id: A0A8I3Q0E4
names: Similarity
messages: Belongs to the beta-catenin family.

9615:MAN2B1
gene id: 9615:MAN2B1
uniprot id: A0A8C0TQU3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9615:TSN
gene id: 9615:TSN
uniprot id: A0A8C0P7P2
uniprot id: A0A8I3PL12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9615:LZTFL1
gene id: 9615:LZTFL1
uniprot id: A0A8C0T2W8
uniprot id: A0A8I3RX08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9615:RFC5
gene id: 9615:RFC5
uniprot id: A0A8C0TU87
uniprot id: A0A8I3SAL9
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9615:THADA
gene id: 9615:THADA
uniprot id: A8C750
names: Similarity
messages: Belongs to the THADA family.

9615:TM4SF5
gene id: 9615:TM4SF5
uniprot id: A0A8C0MPX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9615:UCHL3
gene id: 9615:UCHL3
uniprot id: A0A8C0MTB6
uniprot id: A0A8I3PSJ9
uniprot id: A0A8I3Q5H6
names: Similarity
messages: Belongs to the peptidase C12 family.

9615:MED27
gene id: 9615:MED27
uniprot id: A0A8C0NL17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:P2RY2
gene id: 9615:P2RY2
uniprot id: A0A8C0N8F9
uniprot id: A0A8I3MZ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:CLDN19
gene id: 9615:CLDN19
uniprot id: A0A8C0S3A9
uniprot id: A0A8I3S1X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:FLT1
gene id: 9615:FLT1
uniprot id: A0A8C0NYS8
uniprot id: A0A8I3PN58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:WNT7B
gene id: 9615:WNT7B
uniprot id: A0A8C0MHU1
uniprot id: A0A8C0MR27
uniprot id: A0A8I3N6B8
uniprot id: A0A8I3RVX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:UACA
gene id: 9615:UACA
uniprot id: Q9GL21
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the apoptosome complex, composed of APAF1, pro-caspase-9 and UACA. In the complex, it probably interacts directly with APAF1. Interacts with LGALS3, ARF6 and ACTB. Interacts with RAB39A (By similarity).
messages: Cytoplasm
messages: Highly expressed in adrenal, testis, kidney and large intestine.
messages: Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity).
messages: Nucleus
messages: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
messages: Up-regulated in stimulated thyroids. Down-regulated by forskolin and TSH. Up-regulated by EGF.
messages: cytoskeleton

9615:CYB5RL
gene id: 9615:CYB5RL
uniprot id: A0A8C0M5R8
uniprot id: A0A8I3RYN6
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9615:CEBPB
gene id: 9615:CEBPB
uniprot id: A0A8I3Q8Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9615:HMOX2
gene id: 9615:HMOX2
uniprot id: A0A8C0SLY3
uniprot id: A0A8I3MH42
names: Similarity
messages: Belongs to the heme oxygenase family.

9615:ZNF768
gene id: 9615:ZNF768
uniprot id: A0A8C0M461
uniprot id: A0A8I3P145
names: Subcellular Location Annotation
messages: Nucleus

9615:PMVK
gene id: 9615:PMVK
uniprot id: A0A8C0PIS1
uniprot id: A0A8I3S0N8
names: Subcellular Location Annotation
messages: cytosol

9615:CHRNA1
gene id: 9615:CHRNA1
uniprot id: Q9XS62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:RIMBP2
gene id: 9615:RIMBP2
uniprot id: A0A8P0PEL6
names: Similarity
messages: Belongs to the RIMBP family.

9615:LDHA
gene id: 9615:LDHA
uniprot id: A0A8C0RS21
uniprot id: A0A8P0NBD5
uniprot id: A0A8P0SQF5
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9615:BNIP1
gene id: 9615:BNIP1
uniprot id: A0A8C0LX14
names: Subcellular Location Annotation
messages: Membrane

9615:ACSM5
gene id: 9615:ACSM5
uniprot id: A0A8C0LUZ2
uniprot id: A0A8I3RUC4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:COPG1
gene id: 9615:COPG1
uniprot id: A0A8C0Z7D6
uniprot id: A0A8I3PC55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9615:ZKSCAN2
gene id: 9615:ZKSCAN2
uniprot id: A0A8C0RRI8
uniprot id: A0A8I3MF99
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:KIF19
gene id: 9615:KIF19
uniprot id: A0A8P0SSG4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:TM7SF3
gene id: 9615:TM7SF3
uniprot id: A0A8P0SG41
names: Subcellular Location Annotation
messages: Membrane

9615:TDP1
gene id: 9615:TDP1
uniprot id: A0A8C0PVZ0
uniprot id: A0A8I3NDZ4
uniprot id: A0A8I3NK23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9615:OSMR
gene id: 9615:OSMR
uniprot id: A0A8P0NJS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9615:MIEF1
gene id: 9615:MIEF1
uniprot id: A0A8C0NSM9
uniprot id: A0A8I3PLE3
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9615:RPL3
gene id: 9615:RPL3
uniprot id: A0A8C0Q751
uniprot id: A0A8I3PMB8
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9615:OPRL1
gene id: 9615:OPRL1
uniprot id: A0A8C0QAW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

9615:PFN3
gene id: 9615:PFN3
uniprot id: A0A8C0SP78
uniprot id: A0A8I3N5I2
names: Similarity
messages: Belongs to the profilin family.

9615:RTF2
gene id: 9615:RTF2
uniprot id: A0A8C0SVL2
uniprot id: A0A8I3Q6G3
uniprot id: A0A8P0PBH3
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9615:SLC2A9
gene id: 9615:SLC2A9
uniprot id: A0A8C0SPP5
uniprot id: A0A8P0NTE5
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9615:PIGU
gene id: 9615:PIGU
uniprot id: A0A8C0RZK0
uniprot id: A0A8I3S213
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:OBP2B
gene id: 9615:OBP2B
uniprot id: O18873
names: Allergen
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Causes an allergic reaction in human.
messages: Secreted
messages: Tongue epithelial tissue.

9615:MSMP
gene id: 9615:MSMP
uniprot id: A0A8C0SEN5
uniprot id: A0A8I3ND26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9615:FGF1
gene id: 9615:FGF1
uniprot id: A0A8C0QGP1
uniprot id: J9NTP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9615:ANKRD34C
gene id: 9615:ANKRD34C
uniprot id: A0A8I3MZ87
names: Similarity
messages: Belongs to the ANKRD34 family.

9615:QPRT
gene id: 9615:QPRT
uniprot id: A0A8C0SLU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

9615:NXPH1
gene id: 9615:NXPH1
uniprot id: A0A8I3PJL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9615:TNFRSF25
gene id: 9615:TNFRSF25
uniprot id: A0A8C0S8J4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TAF5L
gene id: 9615:TAF5L
uniprot id: A0A8C0NE82
uniprot id: A0A8I3MKA4
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9615:SEPTIN8
gene id: 9615:SEPTIN8
uniprot id: A0A8C0NA87
uniprot id: A0A8I3NEQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Presynapse
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: synaptic vesicle membrane

9615:TAS2R5
gene id: 9615:TAS2R5
uniprot id: A0A8C0QET1
uniprot id: Q2ABD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:LARS2
gene id: 9615:LARS2
uniprot id: A0A8P0NFW9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:CWC25
gene id: 9615:CWC25
uniprot id: A0A8C0MAY2
uniprot id: A0A8I3RXU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9615:CHRM1
gene id: 9615:CHRM1
uniprot id: A0A8C0MJA7
uniprot id: A0A8I3RVA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9615:TNFAIP1
gene id: 9615:TNFAIP1
uniprot id: A0A8C0T9F1
uniprot id: A0A8I3NFW8
names: Similarity
messages: Belongs to the BACURD family.

9615:RTN1
gene id: 9615:RTN1
uniprot id: Q6IM72
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:CTPS2
gene id: 9615:CTPS2
uniprot id: A0A8C0SM95
uniprot id: A0A8I3QAX6
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9615:LDHB
gene id: 9615:LDHB
uniprot id: A0A8C0Z6I0
uniprot id: A0A8I3NY38
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9615:FIBIN
gene id: 9615:FIBIN
uniprot id: A0A8C0RRE7
uniprot id: A0A8I3PPG3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9615:OR51R1
gene id: 9615:OR51R1
uniprot id: A0A8C0NW51
uniprot id: A0A8P0SBJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ARF5
gene id: 9615:ARF5
uniprot id: A0A8I3PW77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9615:GK
gene id: 9615:GK
uniprot id: A0A8C0SCZ4
uniprot id: A0A8I3NWT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9615:CRLS1
gene id: 9615:CRLS1
uniprot id: A0A8C0QQU9
uniprot id: A0A8I3PTZ4
uniprot id: A0A8P0SBE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9615:ETFA
gene id: 9615:ETFA
uniprot id: A0A8C0PFF8
uniprot id: A0A8P0TFH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9615:PARVB
gene id: 9615:PARVB
uniprot id: A0A8C0MBM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9615:TAF5
gene id: 9615:TAF5
uniprot id: A0A8C0PRN2
uniprot id: A0A8I3S680
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9615:RENBP
gene id: 9615:RENBP
uniprot id: A0A8C0Z2M0
uniprot id: A0A8I3PZF2
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

9615:TM4SF20
gene id: 9615:TM4SF20
uniprot id: A0A8C0TAS4
uniprot id: A0A8P0NCQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9615:EFNA1
gene id: 9615:EFNA1
uniprot id: A0A8P0SLB8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:XPA
gene id: 9615:XPA
uniprot id: A0A8C0MAC1
uniprot id: A0A8I3NWC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9615:NOL12
gene id: 9615:NOL12
uniprot id: A0A8C0QM19
uniprot id: A0A8P0STF1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

9615:SLITRK1
gene id: 9615:SLITRK1
uniprot id: A0A8C0M9R8
uniprot id: A0A8I3MV17
names: Similarity
messages: Belongs to the SLITRK family.

9615:TCP11L1
gene id: 9615:TCP11L1
uniprot id: A0A8C0RQS5
uniprot id: A0A8I3PSL7
names: Similarity
messages: Belongs to the TCP11 family.

9615:GNG10
gene id: 9615:GNG10
uniprot id: A0A8C0QD15
uniprot id: A0A8I3N081
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:TIMP2
gene id: 9615:TIMP2
uniprot id: Q9TTY1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
messages: Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.
messages: Secreted
messages: The activity of TIMP2 is dependent on the presence of disulfide bonds.

9615:SHROOM1
gene id: 9615:SHROOM1
uniprot id: A0A8C0QH78
uniprot id: A0A8P0N419
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9615:MAS1
gene id: 9615:MAS1
uniprot id: A0A8C0Z5A8
uniprot id: H6TB52
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:CHMP2B
gene id: 9615:CHMP2B
uniprot id: A0A8I3PS98
names: Similarity
messages: Belongs to the SNF7 family.

9615:RGS4
gene id: 9615:RGS4
uniprot id: A0A8C0PAF2
uniprot id: A0A8I3PWB5
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9615:SLC1A3
gene id: 9615:SLC1A3
uniprot id: A0A8C0QPQ6
uniprot id: Q9N280
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9615:SLC7A3
gene id: 9615:SLC7A3
uniprot id: A0A8P0NI56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9615:MYLK2
gene id: 9615:MYLK2
uniprot id: A0A8C0Z4A7
uniprot id: A0A8I3P9R3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May interact with centrin.

9615:PGA
gene id: 9615:PGA
uniprot id: Q9GMY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted
messages: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

9615:IRF9
gene id: 9615:IRF9
uniprot id: A0A8C0RX31
uniprot id: A0A8I3MU00
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:MAP7D1
gene id: 9615:MAP7D1
uniprot id: A0A8I3Q5K7
names: Similarity
messages: Belongs to the MAP7 family.

9615:DCK
gene id: 9615:DCK
uniprot id: A0A8C0NKU9
uniprot id: A0A8I3RWJ4
names: Similarity
messages: Belongs to the DCK/DGK family.

9615:IFGGB2
gene id: 9615:IFGGB2
uniprot id: A0A8C0MX30
uniprot id: J7NP21
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9615:NXF3
gene id: 9615:NXF3
uniprot id: A0A8C0MN57
uniprot id: A0A8I3PQX6
names: Subcellular Location Annotation
messages: Cytoplasm

9615:FGF21
gene id: 9615:FGF21
uniprot id: A0A8C0N592
uniprot id: E2RRP8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:SLC5A6
gene id: 9615:SLC5A6
uniprot id: A0A8C0S0C8
uniprot id: A0A8I3MY61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9615:TAF1A
gene id: 9615:TAF1A
uniprot id: A0A8C0SRZ5
uniprot id: A0A8I3QXN0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9615:MSL3
gene id: 9615:MSL3
uniprot id: A0A8C0MV95
uniprot id: A0A8I3QDH6
names: Subcellular Location Annotation
messages: Nucleus

9615:NNAT
gene id: 9615:NNAT
uniprot id: A0A8C0SZY5
names: Similarity
messages: Belongs to the neuronatin family.

9615:ADGRF5
gene id: 9615:ADGRF5
uniprot id: A0A8C0YY14
uniprot id: A0A8C0YY19
uniprot id: A0A8I3S016
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9615:KIF2C
gene id: 9615:KIF2C
uniprot id: A0A8C0RKF8
uniprot id: A0A8I3Q0S1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:GALNT2
gene id: 9615:GALNT2
uniprot id: A0A8I3MHQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:STK11
gene id: 9615:STK11
uniprot id: A0A8C0NS48
uniprot id: A0A8I3ND82
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

9615:OTOP2
gene id: 9615:OTOP2
uniprot id: A0A8P0T5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9615:MFN2
gene id: 9615:MFN2
uniprot id: A0A8C0Q6Z6
uniprot id: E2R3M9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9615:MIGA1
gene id: 9615:MIGA1
uniprot id: A0A8C0MMH5
names: Similarity
messages: Belongs to the mitoguardin family.

9615:AKR1E2
gene id: 9615:AKR1E2
uniprot id: A0A8C0M3S5
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9615:TMEM39A
gene id: 9615:TMEM39A
uniprot id: A0A8C0MN71
uniprot id: A0A8I3NPL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9615:ATP2B3
gene id: 9615:ATP2B3
uniprot id: A0A8C0SWG8
uniprot id: A0A8I3PJ46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:MIOX
gene id: 9615:MIOX
uniprot id: A0A8C0SNM6
uniprot id: A0A8P0S6L9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

9615:RRP15
gene id: 9615:RRP15
uniprot id: A0A8P0PG79
names: Similarity
messages: Belongs to the RRP15 family.

9615:NTN4
gene id: 9615:NTN4
uniprot id: A0A8C0NCY2
uniprot id: A0A8I3PKJ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:C1RL
gene id: 9615:C1RL
uniprot id: A0A8P0NSA4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CD93
gene id: 9615:CD93
uniprot id: A0A8C0TI12
uniprot id: A0A8P0N7X6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:OR51P1
gene id: 9615:OR51P1
uniprot id: A4GXA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ERLIN2
gene id: 9615:ERLIN2
uniprot id: A0A8C0RM63
uniprot id: A0A8I3NND5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9615:H2AC8
gene id: 9615:H2AC8
uniprot id: A0A8I3S9E1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:NID1
gene id: 9615:NID1
uniprot id: A0A8P0P645
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9615:FUT2
gene id: 9615:FUT2
uniprot id: A0A8I3MCT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9615:TFR2
gene id: 9615:TFR2
uniprot id: A0A8C0SHF8
uniprot id: A0A8I3MDN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9615:CLDN2
gene id: 9615:CLDN2
uniprot id: Q95KM6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
messages: Cell membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.
messages: tight junction

9615:HTR1E
gene id: 9615:HTR1E
uniprot id: A0A8C0QRS3
uniprot id: A0A8I3RXP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:VAMP7
gene id: 9615:VAMP7
uniprot id: A0A8C0N415
uniprot id: A0A8I3NVA5
uniprot id: A0A8I3NW15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9615:NR2C2
gene id: 9615:NR2C2
uniprot id: A0A8C0T345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:APOL6
gene id: 9615:APOL6
uniprot id: A0A8C0Q3J3
uniprot id: A0A8I3N1A4
names: Similarity
messages: Belongs to the apolipoprotein L family.

9615:SERINC1
gene id: 9615:SERINC1
uniprot id: A0A8P0S799
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9615:SRFBP1
gene id: 9615:SRFBP1
uniprot id: A0A8I3N2Q8
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9615:ANAPC5
gene id: 9615:ANAPC5
uniprot id: A0A8C0P9R9
uniprot id: A0A8I3PPD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9615:TMEM59
gene id: 9615:TMEM59
uniprot id: A0A8C0M8D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:GNPNAT1
gene id: 9615:GNPNAT1
uniprot id: A0A8C0RUL0
uniprot id: A0A8I3MSH5
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9615:GLRX
gene id: 9615:GLRX
uniprot id: A0A8C0NAE1
uniprot id: A0A8I3NFC4
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9615:HBEGF
gene id: 9615:HBEGF
uniprot id: A0A8C0MA18
uniprot id: A0A8C0PXH1
uniprot id: A0A8P0TUU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:F9
gene id: 9615:F9
uniprot id: P19540
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by factor XIa, which excises the activation peptide. The propeptide can also be removed by snake venom protease.
messages: Belongs to the peptidase S1 family.
messages: Calcium binds to the gamma-carboxyglutamic acid (Gla) residues in the Gla domain. Calcium can also bind, with stronger affinity, to another site beyond the Gla domain. Under physiological ion concentrations, Ca(2+) is displaced by Mg(2+) from some of the gammaglutamate residues in the N-terminal Gla domain. This leads to a subtle conformation change that may affect the interaction with its binding protein.
messages: Defects in F9 are the cause of hemophilia B (HEMB).
messages: Detected in the liver.
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Heterodimer of a light chain and a heavy chain; disulfide-linked. Interacts with SERPINC1.
messages: Predominantly O-glucosylated at Ser-92 by POGLUT1 in vitro.
messages: Secreted
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

9615:AMOTL1
gene id: 9615:AMOTL1
uniprot id: A0A8C0NNX4
uniprot id: A0A8C0NVM4
uniprot id: A0A8C0P0E4
uniprot id: A0A8I3PFB7
names: Similarity
messages: Belongs to the angiomotin family.

9615:HACD3
gene id: 9615:HACD3
uniprot id: A0A8C0TU14
uniprot id: A0A8I3PWW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:OPA1
gene id: 9615:OPA1
uniprot id: A0A8C0TFT4
uniprot id: A0A8I3PQW8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9615:MYF5
gene id: 9615:MYF5
uniprot id: A0A8C0P3A7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9615:RPS11
gene id: 9615:RPS11
uniprot id: A0A8C0LWV3
uniprot id: A0A8I3PL85
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9615:SSBP1
gene id: 9615:SSBP1
uniprot id: A0A8C0PG91
uniprot id: E2RST4
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9615:PRR5L
gene id: 9615:PRR5L
uniprot id: A0A8C0YY37
uniprot id: A0A8I3PJZ6
names: Similarity
messages: Belongs to the PROTOR family.

9615:SLC2A8
gene id: 9615:SLC2A8
uniprot id: B4YY04
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9615:CKAP2
gene id: 9615:CKAP2
uniprot id: A0A8C0Q7G0
uniprot id: A0A8I3PJR4
names: Similarity
messages: Belongs to the CKAP2 family.

9615:RBM5
gene id: 9615:RBM5
uniprot id: A0A8C0N9Q4
uniprot id: A0A8I3S3L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9615:WNT11
gene id: 9615:WNT11
uniprot id: A0A8C0NS68
uniprot id: A0A8I3RY70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:RPS23
gene id: 9615:RPS23
uniprot id: A0A8C0Q1W3
uniprot id: A0A8I3S4N6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9615:SLC8B1
gene id: 9615:SLC8B1
uniprot id: A0A8I3PJN7
names: Subcellular Location Annotation
messages: Membrane

9615:TMEM176A
gene id: 9615:TMEM176A
uniprot id: A0A8C0PM27
uniprot id: A0A8P0NS61
names: Similarity
messages: Belongs to the TMEM176 family.

9615:HMGN3
gene id: 9615:HMGN3
uniprot id: A0A8C0MR89
uniprot id: A0A8I3N122
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
messages: Nucleus

9615:ANP32A
gene id: 9615:ANP32A
uniprot id: A0A8I3S455
names: Similarity
messages: Belongs to the ANP32 family.

9615:JMJD1C
gene id: 9615:JMJD1C
uniprot id: A0A8C0PSY8
uniprot id: A0A8I3RQX1
names: Subcellular Location Annotation
messages: Nucleus

9615:PLK2
gene id: 9615:PLK2
uniprot id: A0A8P0SCA9
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9615:LAMP2
gene id: 9615:LAMP2
uniprot id: A0A8C0SR91
uniprot id: A0A8I3S2Z8
uniprot id: A0A8P0NJM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9615:PSENEN
gene id: 9615:PSENEN
uniprot id: A0A8C0MHU8
uniprot id: J9P0J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9615:ENKUR
gene id: 9615:ENKUR
uniprot id: A0A8C0RKV2
uniprot id: A0A8I3MP67
names: Subcellular Location Annotation
messages: cilium axoneme

9615:XKR9
gene id: 9615:XKR9
uniprot id: A0A8I3SA41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9615:PSME2
gene id: 9615:PSME2
uniprot id: A0A8C0QE81
uniprot id: A0A8I3MUE2
names: Similarity
messages: Belongs to the PA28 family.

9615:PRNP
gene id: 9615:PRNP
uniprot id: O46593
uniprot id: Q1W2J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane

9615:STARD5
gene id: 9615:STARD5
uniprot id: A0A8C0PP66
uniprot id: A0A8I3MLS9
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9615:SLC25A48
gene id: 9615:SLC25A48
uniprot id: A0A8C0MPM8
uniprot id: A0A8C0REG5
uniprot id: A0A8P0NRA9
uniprot id: A0A8P0S708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:AGBL4
gene id: 9615:AGBL4
uniprot id: A0A8C0SGE7
uniprot id: A0A8I3PWL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9615:KHDRBS2
gene id: 9615:KHDRBS2
uniprot id: A0A8C0MEQ0
uniprot id: A0A8I3N4D2
names: Similarity
messages: Belongs to the KHDRBS family.

9615:OR11J6
gene id: 9615:OR11J6
uniprot id: A0A8C0MR54
uniprot id: G3FJD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:LOC490151
gene id: 9615:LOC490151
uniprot id: A0A8C0QDD4
uniprot id: A0A8I3NW45
names: Subcellular Location Annotation
messages: Membrane

9615:SPTAN1
gene id: 9615:SPTAN1
uniprot id: A0A8I3Q1F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9615:DNM1
gene id: 9615:DNM1
uniprot id: B4YUE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

9615:FZD10
gene id: 9615:FZD10
uniprot id: A0A8C0RP31
uniprot id: A0A8I3SCK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9615:RRP8
gene id: 9615:RRP8
uniprot id: A0A8C0RF14
uniprot id: A0A8I3RUP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: nucleolus

9615:TIMELESS
gene id: 9615:TIMELESS
uniprot id: A0A8C0NCH0
uniprot id: A0A8I3N475
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

9615:USP20
gene id: 9615:USP20
uniprot id: A0A8I3S6H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9615:DCT
gene id: 9615:DCT
uniprot id: L0N6C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9615:LOC481650
gene id: 9615:LOC481650
uniprot id: A0A8C0NZP1
uniprot id: A0A8I3NGJ8
names: Similarity
messages: Belongs to the NipSnap family.

9615:SLC25A25
gene id: 9615:SLC25A25
uniprot id: A0A8C0N732
uniprot id: A0A8C0RIS5
uniprot id: A0A8C0STK7
uniprot id: A0A8C0SUJ0
uniprot id: A0A8P0NUP3
uniprot id: A0A8P0P783
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:DDX41
gene id: 9615:DDX41
uniprot id: A0A8C0SJZ2
uniprot id: A0A8I3NC92
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

9615:ITGB2
gene id: 9615:ITGB2
uniprot id: A0A8C0Z0G4
uniprot id: A0A8I3S561
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9615:EXOC6
gene id: 9615:EXOC6
uniprot id: E2R766
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (By similarity). Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
messages: Cytoplasm
messages: Midbody ring
messages: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with CNTRL. Interacts with RAB11A in a GTP-dependent manner (By similarity).
messages: growth cone
messages: perinuclear region

9615:ATP4B
gene id: 9615:ATP4B
uniprot id: P33704
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: N-glycosylation is necessary for assembly and functional expression of the pump at the plasma membrane.
messages: The ATPase pump is composed of two subunits: alpha (catalytic) and beta (regulatory). Interacts with alpha subunit ATP12A; this interaction is required for the formation of a functionally active pump and targeting at the plasma membrane (By similarity). Interacts (via N-terminus) with alpha subunit ATP4A (via the P-domain) (By similarity).
messages: The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
messages: The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity).

9615:SERPINB10
gene id: 9615:SERPINB10
uniprot id: A0A8C0NEC0
uniprot id: A0A8I3MHW7
names: Similarity
messages: Belongs to the serpin family.

9615:PUS7L
gene id: 9615:PUS7L
uniprot id: A0A8P0SET6
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9615:PPFIA1
gene id: 9615:PPFIA1
uniprot id: A0A8C0PD62
uniprot id: A0A8I3NTY6
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9615:SCN1A
gene id: 9615:SCN1A
uniprot id: A0A8P0SG87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9615:MEGF10
gene id: 9615:MEGF10
uniprot id: A0A8I3NCL3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CCN5
gene id: 9615:CCN5
uniprot id: A0A8P0NBL7
names: Similarity
messages: Belongs to the CCN family.

9615:IL1RAPL1
gene id: 9615:IL1RAPL1
uniprot id: A0A8C0SAK0
uniprot id: A0A8I3QQB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

9615:CTDP1
gene id: 9615:CTDP1
uniprot id: A0A8C0RAV2
uniprot id: A0A8I3MFD6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

9615:ATP5PO
gene id: 9615:ATP5PO
uniprot id: A0A8C0T488
uniprot id: J9P621
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9615:HM13
gene id: 9615:HM13
uniprot id: A0A8C0MQ52
uniprot id: A0A8I3S0I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9615:RAB8A
gene id: 9615:RAB8A
uniprot id: P61007
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus
messages: Interacts (GTP-bound form) with MICALL1; regulates RAB8A association with recycling endosomes (By similarity). Interacts with MICALL2; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts (GTP-bound form) with MICAL1, MICALCL, MICAL3 and EHBP1L1; two molecules of RAB8A can bind to one molecule of the effector protein; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible (By similarity). Interacts (GTP-bound form) with EHBP1 (By similarity). Interacts with EHD1 (By similarity). Interacts with MAP4K2 and SYTL4 (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with RABIF, RIMS2, RPH3A and RPH3A (By similarity). Interacts with OPTN (By similarity). Interacts with RAB3IP (By similarity). Interacts with MYO5B (By similarity). Interacts with PIFO (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with OCRL (By similarity). Interacts with AHI1 (By similarity). Interacts with DCDC1 (By similarity). Interacts with LRRK2; interaction facilitates phosphorylation of Thr-72 (By similarity). Interacts with RAB31P, GDI1, GDI2, CHM, CHML, RABGGTA, RABGGTB, TBC1D15 and INPP5B; these interactions are dependent on Thr-72 not being phosphorylated (By similarity). Interacts with RILPL1 and RILPL2; these interactions are dependent on the phosphorylation of Thr-72 by LRRK2 (By similarity). Interacts with DZIP1; prevents inhibition by the GDP-dissociation inhibitor GDI2 (By similarity).
messages: Midbody
messages: Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Recycling endosome membrane
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase (By similarity). Activated in response to insulin (By similarity).
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi (By similarity). Together with MYO5B and RAB11A participates in epithelial cell polarization. Also involved in membrane trafficking to the cilium and ciliogenesis (By similarity). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (By similarity).
messages: centriole
messages: cilium
messages: cilium basal body
messages: phagosome membrane

9615:PAN2
gene id: 9615:PAN2
uniprot id: A0A8C0NBF8
uniprot id: A0A8I3RVS0
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9615:SLC14A1
gene id: 9615:SLC14A1
uniprot id: A0A8C0QAU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9615:PURA
gene id: 9615:PURA
uniprot id: A0A8I3RPP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9615:CRYGA
gene id: 9615:CRYGA
uniprot id: A0A8C0S135
uniprot id: A9JPX6
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9615:HSDL1
gene id: 9615:HSDL1
uniprot id: A0A8C0SUN8
uniprot id: A0A8I3NYZ5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:CLSTN3
gene id: 9615:CLSTN3
uniprot id: A0A8C0NX68
uniprot id: A0A8P0NPR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9615:GNB1
gene id: 9615:GNB1
uniprot id: P62872
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity). Forms a complex with GNAO1 and GNG3. Interacts with ARHGEF18 and RASD2 (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.

9615:SENP8
gene id: 9615:SENP8
uniprot id: A0A8C0NLX5
uniprot id: A0A8I3PIP6
names: Similarity
messages: Belongs to the peptidase C48 family.

9615:ARSG
gene id: 9615:ARSG
uniprot id: Q32KH9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate (By similarity). Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin (By similarity).
messages: Lysosome
messages: N-glycosylated with both high mannose and complex type sugars.
messages: The 63-kDa precursor undergoes proteolytic processing in two steps, yielding two fragments in the first step (apparent molecular masses of 44 and 18 kDa) (By similarity). In the second step, the 44-kDa fragment is processed further to the 34- and 10-kDa chains. The 10-kDa chain is a cleavage product of the 44-kDa fragment but linked to the 18-kDa chain through a disulfide bridge (By similarity).
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:OTULIN
gene id: 9615:OTULIN
uniprot id: A0A8C0TB91
uniprot id: A0A8I3RYD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9615:KRT41
gene id: 9615:KRT41
uniprot id: A0A8C0YW62
uniprot id: A0A8I3RZQ2
names: Similarity
messages: Belongs to the intermediate filament family.

9615:LOC485601
gene id: 9615:LOC485601
uniprot id: A0A8C0T5P6
uniprot id: A0A8I3NW57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm

9615:FMR1
gene id: 9615:FMR1
uniprot id: A0A8C0NG67
uniprot id: A0A8C0NQG5
uniprot id: A0A8I3PAW4
uniprot id: A0A8I3PB79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9615:ABRAXAS1
gene id: 9615:ABRAXAS1
uniprot id: A0A8C0Z6D0
uniprot id: A0A8I3PGI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
messages: Nucleus

9615:SPAG11E
gene id: 9615:SPAG11E
uniprot id: A0A8C0MZ35
uniprot id: Q30KR2
names: Subcellular Location Annotation
messages: Secreted

9615:SERPIND1
gene id: 9615:SERPIND1
uniprot id: A0A8C0TCZ2
names: Similarity
messages: Belongs to the serpin family.

9615:CANX
gene id: 9615:CANX
uniprot id: P24643
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Interacts with MAPK3/ERK1 (By similarity). Interacts with KCNH2 (By similarity). Associates with ribosomes (By similarity). Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins (By similarity). Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1 (By similarity). Interacts with PPIB (PubMed:20801878). Interacts with ZNRF4 (By similarity). Interacts with SMIM22 (By similarity). Interacts with TMX2 (By similarity). Interacts with TMEM35A/NACHO and CHRNA7 (By similarity). Interacts with reticulophagy regulators RETREG2 and RETREG3 (By similarity).
messages: Melanosome
messages: Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins (By similarity).
messages: Phosphorylated at Ser-565 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
messages: Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.

9615:QTRT2
gene id: 9615:QTRT2
uniprot id: A0A8C0PW06
uniprot id: A0A8I3P465
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9615:SMC1A
gene id: 9615:SMC1A
uniprot id: A0A8C0N1N1
uniprot id: A0A8C0T3L8
uniprot id: A0A8I3Q022
uniprot id: A0A8P0SXX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9615:SNU13
gene id: 9615:SNU13
uniprot id: A0A8C0SUV3
uniprot id: A0A8I3NPM0
uniprot id: A0A8I3P795
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9615:FEZ2
gene id: 9615:FEZ2
uniprot id: A0A8C0MBR6
uniprot id: A0A8C0RCJ0
uniprot id: A0A8I3NTU6
uniprot id: A0A8I3P4N9
names: Similarity
messages: Belongs to the zygin family.

9615:CALCB
gene id: 9615:CALCB
uniprot id: Q75V94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted
messages: Stimulates cAMP production in porcine kidney cell line LLC-PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor.

9615:KCNK5
gene id: 9615:KCNK5
uniprot id: A0A8C0MJX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:BCAP29
gene id: 9615:BCAP29
uniprot id: A0A8C0YXP3
uniprot id: A0A8I3S9M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9615:RPTOR
gene id: 9615:RPTOR
uniprot id: A0A8C0MJH0
uniprot id: A0A8I3NME4
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9615:TREM1
gene id: 9615:TREM1
uniprot id: A0A8C0MDA6
uniprot id: E2RP37
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:SLC19A2
gene id: 9615:SLC19A2
uniprot id: A0A8C0RSH3
uniprot id: A0A8I3MT32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9615:FGF18
gene id: 9615:FGF18
uniprot id: A0A7U3JWC4
uniprot id: A0A8C0LU80
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:GNG11
gene id: 9615:GNG11
uniprot id: A0A8C0NGJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:FABP7
gene id: 9615:FABP7
uniprot id: A0A8C0RH38
uniprot id: A0A8I3RVB9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Belongs to the calycin superfamily. Lipocalin family.

9615:CD2
gene id: 9615:CD2
uniprot id: A0A8C0SEN8
uniprot id: A0A8I3Q5Y3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:TSPAN15
gene id: 9615:TSPAN15
uniprot id: A0A8C0QF74
uniprot id: A0A8I3MS11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:LHX3
gene id: 9615:LHX3
uniprot id: A0A8C0LY98
uniprot id: E0X4D7
names: Subcellular Location Annotation
messages: Nucleus

9615:TSC22D3
gene id: 9615:TSC22D3
uniprot id: A0A8C0TGK9
uniprot id: A0A8C0TKB0
uniprot id: A0A8C0TKS8
uniprot id: A0A8I3NZ89
uniprot id: A0A8I3S078
uniprot id: A0A8I3S314
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9615:LOC479649
gene id: 9615:LOC479649
uniprot id: P04813
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: extracellular space

9615:ACOT8
gene id: 9615:ACOT8
uniprot id: A0A8C0QB21
uniprot id: A0A8I3NZF5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9615:ARPC5L
gene id: 9615:ARPC5L
uniprot id: A0A8C0TC90
uniprot id: A0A8I3RVN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: May be a component of the Arp2/3 complex in which it may replace ARPC5.
messages: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9615:PIAS4
gene id: 9615:PIAS4
uniprot id: A0A8C0QIF7
uniprot id: A0A8I3N076
names: Similarity
messages: Belongs to the PIAS family.

9615:RBM47
gene id: 9615:RBM47
uniprot id: Q9XSR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Nucleus

9615:STAT4
gene id: 9615:STAT4
uniprot id: A0A8C0NL42
uniprot id: A0A8C0SQ64
uniprot id: A0A8I3PTH5
uniprot id: A0A8I3QBC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9615:THBD
gene id: 9615:THBD
uniprot id: Q5W7P8
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in lung, liver, spleen, kidney, pancreas and lymph node. Low expression in heart, cerebrum, urinary bladder and uterus.
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Membrane
messages: N-glycosylated.
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated (By similarity).

9615:TNKS2
gene id: 9615:TNKS2
uniprot id: A0A8C0Z1D4
names: Function
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9615:DLA-12
gene id: 9615:DLA-12
uniprot id: A0A8C0SVD8
uniprot id: O46880
names: Similarity
messages: Belongs to the MHC class I family.

9615:VPS25
gene id: 9615:VPS25
uniprot id: A0A8C0LUY1
uniprot id: A0A8I3NID4
names: Similarity
messages: Belongs to the VPS25 family.

9615:LNPEP
gene id: 9615:LNPEP
uniprot id: A0A8C0NNI0
uniprot id: A0A8P0NA30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Membrane

9615:NRP2
gene id: 9615:NRP2
uniprot id: A0A8C0MSC3
uniprot id: A0A8P0P4D2
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:H2AC6
gene id: 9615:H2AC6
uniprot id: A0A8C0NTQ3
uniprot id: A0A8I3PW10
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:RABGGTA
gene id: 9615:RABGGTA
uniprot id: A0A8C0RXN6
uniprot id: A0A8I3N0I7
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9615:TAF15
gene id: 9615:TAF15
uniprot id: A0A8C0RXV8
uniprot id: A0A8I3RWN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9615:PDXK
gene id: 9615:PDXK
uniprot id: A0A8P0PDH8
names: Similarity
messages: Belongs to the pyridoxine kinase family.

9615:KCTD13
gene id: 9615:KCTD13
uniprot id: A0A8C0SR99
uniprot id: A0A8I3MGD4
names: Similarity
messages: Belongs to the BACURD family.

9615:TMCC2
gene id: 9615:TMCC2
uniprot id: A0A8P0SF10
names: Similarity
messages: Belongs to the TEX28 family.

9615:TSSC4
gene id: 9615:TSSC4
uniprot id: A0A8C0TT89
uniprot id: A0A8I3NUR1
names: Similarity
messages: Belongs to the TSSC4 family.

9615:SNAP23
gene id: 9615:SNAP23
uniprot id: A0A8C0RQF5
uniprot id: A0A8I3S1Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9615:SLC25A11
gene id: 9615:SLC25A11
uniprot id: A0A8C0P6K8
uniprot id: A0A8I3MM43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:PSMB11
gene id: 9615:PSMB11
uniprot id: A0A8C0PV09
uniprot id: A0A8I3MGM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:BEX3
gene id: 9615:BEX3
uniprot id: A0A8C0NTC6
names: Similarity
messages: Belongs to the BEX family.

9615:ACER2
gene id: 9615:ACER2
uniprot id: A0A8C0TA65
uniprot id: A0A8I3S0Z2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:APIP
gene id: 9615:APIP
uniprot id: A0A8C0Z008
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9615:RNPEP
gene id: 9615:RNPEP
uniprot id: A0A8C0LWF7
uniprot id: A0A8I3NUR2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9615:RPL19
gene id: 9615:RPL19
uniprot id: D0VWQ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9615:CREB1
gene id: 9615:CREB1
uniprot id: A0A8C0N7M6
uniprot id: A0A8C0TY64
uniprot id: A0A8I3PDE7
uniprot id: A0A8I3S2U7
names: Subcellular Location Annotation
messages: Nucleus

9615:IMPA2
gene id: 9615:IMPA2
uniprot id: A0A8C0YT58
uniprot id: A0A8I3RSD9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9615:TPD52L2
gene id: 9615:TPD52L2
uniprot id: A0A8C0PBQ4
uniprot id: A0A8C0PBR2
uniprot id: A0A8C0RSB9
uniprot id: A0A8I3P7S9
uniprot id: A0A8I3S471
names: Similarity
messages: Belongs to the TPD52 family.

9615:BMP4
gene id: 9615:BMP4
uniprot id: A0A8C0M2B6
uniprot id: A0A8I3MKS3
names: Similarity
messages: Belongs to the TGF-beta family.

9615:CYB5R4
gene id: 9615:CYB5R4
uniprot id: A0A8C0MD08
uniprot id: A0A8I3NKZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9615:APOD
gene id: 9615:APOD
uniprot id: A0A8C0PAS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9615:AQP2
gene id: 9615:AQP2
uniprot id: A0A8C0PGG7
uniprot id: A0A8I3P6A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:BLMH
gene id: 9615:BLMH
uniprot id: A0A8C0Q1A1
uniprot id: A0A8I3NNT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9615:PYCARD
gene id: 9615:PYCARD
uniprot id: A0A8C0S8E3
uniprot id: A0A8I3RYZ8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9615:UROS
gene id: 9615:UROS
uniprot id: A0A8C0TFR4
uniprot id: A0A8P0SHG6
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9615:ACSL1
gene id: 9615:ACSL1
uniprot id: A0A8P0P632
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9615:CDC37
gene id: 9615:CDC37
uniprot id: A0A8C0T995
uniprot id: A0A8I3PXI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9615:KCNK10
gene id: 9615:KCNK10
uniprot id: A0A8C0M8T0
uniprot id: A0A8I3N317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:RSL24D1
gene id: 9615:RSL24D1
uniprot id: A0A8C0TX87
uniprot id: A0A8I3QGN6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9615:CRISP2
gene id: 9615:CRISP2
uniprot id: A0A8C0Q3D4
uniprot id: A0A8I3N019
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:APOBEC1
gene id: 9615:APOBEC1
uniprot id: A0A8P0NYA6
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9615:NUS1
gene id: 9615:NUS1
uniprot id: A0A8C0N8W2
uniprot id: A0A8I3N3L1
names: Similarity
messages: Belongs to the UPP synthase family.

9615:OXT
gene id: 9615:OXT
uniprot id: A0A8C0SUC8
uniprot id: A0A8I3NWL0
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9615:SLC39A6
gene id: 9615:SLC39A6
uniprot id: A0A8C0M0G7
uniprot id: A0A8I3MT92
names: Subcellular Location Annotation
messages: Membrane

9615:FLT3
gene id: 9615:FLT3
uniprot id: Q4ZHV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Membrane

9615:RIOK3
gene id: 9615:RIOK3
uniprot id: A0A8C0PJU6
uniprot id: A0A8I3NRB3
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

9615:CPA3
gene id: 9615:CPA3
uniprot id: A0A8I3PC11
names: Similarity
messages: Belongs to the peptidase M14 family.

9615:CYP26B1
gene id: 9615:CYP26B1
uniprot id: A0A8C0T1I2
uniprot id: A0A8I3P615
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:PPP1R35
gene id: 9615:PPP1R35
uniprot id: A0A8C0NWP5
uniprot id: A0A8I3MLR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP1R35 family.
messages: centriole

9615:GABARAPL2
gene id: 9615:GABARAPL2
uniprot id: A0A8C0M237
uniprot id: A0A8I3PFI1
names: Similarity
messages: Belongs to the ATG8 family.

9615:UNK
gene id: 9615:UNK
uniprot id: Q6EE22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm
messages: Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes.

9615:KIF5B
gene id: 9615:KIF5B
uniprot id: A0A8C0NXA2
uniprot id: A0A8I3N413
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:STX7
gene id: 9615:STX7
uniprot id: A0A8C0YXM9
uniprot id: A0A8I3MUA1
names: Similarity
messages: Belongs to the syntaxin family.

9615:TUBA1C
gene id: 9615:TUBA1C
uniprot id: A0A8C0RPT6
uniprot id: A0A8I3PAA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9615:ANGPT2
gene id: 9615:ANGPT2
uniprot id: A0A8J8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.
messages: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. Interacts with ITGA5.
messages: Secreted
messages: The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.

9615:BRCC3
gene id: 9615:BRCC3
uniprot id: A0A8C0TEH4
uniprot id: A0A8I3Q664
uniprot id: A0A8I3QJH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9615:SENP7
gene id: 9615:SENP7
uniprot id: A0A8I3S4I3
names: Similarity
messages: Belongs to the peptidase C48 family.

9615:TAS2R42
gene id: 9615:TAS2R42
uniprot id: A0A8C0TSM8
uniprot id: Q2ABC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:PIM2
gene id: 9615:PIM2
uniprot id: A0A8C0S661
uniprot id: A0A8I3SCW6
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9615:EBAG9
gene id: 9615:EBAG9
uniprot id: Q865S0
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Golgi apparatus membrane
messages: Homodimer.
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.
messages: The coiled coil domain is necessary for the homodimerization.

9615:GNAQ
gene id: 9615:GNAQ
uniprot id: Q28294
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Binds SLC9A3R1. Forms a complex with PECAM1 and BDKRB2. Interacts with PECAM1 (By similarity). Interacts with GAS2L2 (By similarity).
messages: Golgi apparatus
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNA11, required for heart development (By similarity).
messages: Histaminylated at Gln-209 residues by TGM2.
messages: Nucleus
messages: Nucleus membrane
messages: Palmitoylated by ZDHHC3 and ZDHHC7. Palmitoylation occurs in the Golgi and participates in the localization of GNAQ to the plasma membrane.

9615:SLC17A7
gene id: 9615:SLC17A7
uniprot id: A0A8C0T402
uniprot id: A0A8I3PN97
names: Subcellular Location Annotation
messages: Membrane

9615:ACTR2
gene id: 9615:ACTR2
uniprot id: A0A8C0Q5U2
uniprot id: A0A8C0Q5W7
names: Similarity
messages: Belongs to the actin family.

9615:PRKAR2B
gene id: 9615:PRKAR2B
uniprot id: A0A8C0YXX8
uniprot id: A0A8I3S5X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9615:APPL1
gene id: 9615:APPL1
uniprot id: A0A8P0NAH5
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9615:PPM1G
gene id: 9615:PPM1G
uniprot id: A0A8C0S6T1
uniprot id: A0A8I3N2G1
names: Similarity
messages: Belongs to the PP2C family.

9615:RNF111
gene id: 9615:RNF111
uniprot id: A0A8C0TZ76
uniprot id: A0A8I3RZ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

9615:BMT2
gene id: 9615:BMT2
uniprot id: A0A8P0TIQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9615:STT3A
gene id: 9615:STT3A
uniprot id: F1PJP5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STT3 family.
messages: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A (PubMed:12887896).
messages: Component of the oligosaccharyltransferase (OST) complex (By similarity). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:12887896, PubMed:15835887, PubMed:25135935). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:29519914).
messages: Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.
messages: Endoplasmic reticulum membrane

9615:TMEM233
gene id: 9615:TMEM233
uniprot id: A0A8C0T131
uniprot id: A0A8P0NR50
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9615:NRXN1
gene id: 9615:NRXN1
uniprot id: A0A8C0REN0
uniprot id: A0A8C0REQ8
uniprot id: A0A8C0SP61
uniprot id: A0A8I3N2C2
uniprot id: A0A8I3N5M6
uniprot id: A0A8I3RV85
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MTFR1
gene id: 9615:MTFR1
uniprot id: A0A8P0NSS4
uniprot id: A0A8P0P4W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9615:NPRL3
gene id: 9615:NPRL3
uniprot id: A0A8C0NMM6
uniprot id: A0A8C0NSC7
uniprot id: A0A8I3MHM3
uniprot id: A0A8I3MHV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

9615:HIGD2A
gene id: 9615:HIGD2A
uniprot id: A0A8P0TTD0
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9615:NDUFS7
gene id: 9615:NDUFS7
uniprot id: A0A8C0NPZ7
uniprot id: A0A8I3ND96
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

9615:TSPAN1
gene id: 9615:TSPAN1
uniprot id: A0A8C0SU32
uniprot id: A0A8I3P9L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:EIF3I
gene id: 9615:EIF3I
uniprot id: A0A8I3MMU7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9615:A3GALT2
gene id: 9615:A3GALT2
uniprot id: A0A8C0T5Y4
uniprot id: A0A8P0SFJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9615:PDLIM3
gene id: 9615:PDLIM3
uniprot id: A0A8C0NEH4
uniprot id: A0A8C0NLN8
uniprot id: A0A8I3P7P2
uniprot id: A0A8I3PAR1
names: Subcellular Location Annotation
messages: Z line

9615:EDN1
gene id: 9615:EDN1
uniprot id: P13206
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
messages: Secreted

9615:AAR2
gene id: 9615:AAR2
uniprot id: A0A8C0RT16
uniprot id: A0A8I3PVG7
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9615:SELENBP1
gene id: 9615:SELENBP1
uniprot id: A0A8C0SJE9
uniprot id: A0A8I3PHV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9615:RNPC3
gene id: 9615:RNPC3
uniprot id: A0A8C0NW40
uniprot id: A0A8I3NH24
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

9615:CHRNA7
gene id: 9615:CHRNA7
uniprot id: A0A8P0NCK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:FAM161A
gene id: 9615:FAM161A
uniprot id: A0A8P0SQ10
names: Similarity
messages: Belongs to the FAM161 family.

9615:PGS1
gene id: 9615:PGS1
uniprot id: A0A8C0RB91
uniprot id: A0A8I3NU32
uniprot id: A0A8I3NU67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9615:MRPL52
gene id: 9615:MRPL52
uniprot id: A0A8C0Q320
uniprot id: A0A8C0RUZ0
uniprot id: A0A8I3MEW2
uniprot id: A0A8I3RQE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9615:LYVE1
gene id: 9615:LYVE1
uniprot id: A0A8C0M7M0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:AVPR1A
gene id: 9615:AVPR1A
uniprot id: E2R8D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9615:CD53
gene id: 9615:CD53
uniprot id: A0A8C0SFV0
uniprot id: A0A8I3MMD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:FRG1
gene id: 9615:FRG1
uniprot id: A0A8C0NVG8
uniprot id: E2RKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9615:CHST7
gene id: 9615:CHST7
uniprot id: A0A8C0SQG4
uniprot id: A0A8I3Q2X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9615:MRM2
gene id: 9615:MRM2
uniprot id: A0A8C0MEE6
uniprot id: A0A8I3NFX7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

9615:RHBDD2
gene id: 9615:RHBDD2
uniprot id: A0A8C0SHN3
uniprot id: A0A8I3MSQ4
names: Subcellular Location Annotation
messages: Membrane

9615:AGMAT
gene id: 9615:AGMAT
uniprot id: A0A8C0QB28
uniprot id: A0A8I3RP09
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

9615:FAM91A1
gene id: 9615:FAM91A1
uniprot id: A0A8C0MP74
uniprot id: A0A8I3NEI7
names: Similarity
messages: Belongs to the FAM91 family.

9615:ATP6V0D1
gene id: 9615:ATP6V0D1
uniprot id: A0A8C0YZP4
uniprot id: A0A8I3NAA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9615:H2BC19
gene id: 9615:H2BC19
uniprot id: A0A8C0MIB7
uniprot id: A0A8P0T098
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:MTX3
gene id: 9615:MTX3
uniprot id: A0A8C0NML1
uniprot id: A0A8C0RXN4
uniprot id: A0A8I3N4P9
uniprot id: A0A8I3RUM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:ADIPOR1
gene id: 9615:ADIPOR1
uniprot id: A0A8C0RBA1
uniprot id: A0A8I3NRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:GALNT6
gene id: 9615:GALNT6
uniprot id: A0A8C0PF08
uniprot id: A0A8P0SD70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:CX3CL1
gene id: 9615:CX3CL1
uniprot id: A0A8C0YVN8
uniprot id: E2RTH0
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9615:UBE2M
gene id: 9615:UBE2M
uniprot id: A0A8C0RW57
uniprot id: A0A8I3MA68
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:NKX6-3
gene id: 9615:NKX6-3
uniprot id: A0A8C0NXP1
uniprot id: A0A8I3MZB4
names: Subcellular Location Annotation
messages: Nucleus

9615:ITPR3
gene id: 9615:ITPR3
uniprot id: A0A8I3S857
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9615:UQCR10
gene id: 9615:UQCR10
uniprot id: A0A8C0P344
uniprot id: A0A8P0SH19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9615:YIPF1
gene id: 9615:YIPF1
uniprot id: A0A8C0M925
uniprot id: A0A8I3NX89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9615:THG1L
gene id: 9615:THG1L
uniprot id: A0A8C0N021
uniprot id: A0A8I3MZC1
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

9615:VPS41
gene id: 9615:VPS41
uniprot id: A0A8C0M6S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9615:SERBP1
gene id: 9615:SERBP1
uniprot id: A0A8C0RZ75
uniprot id: A0A8I3QC63
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:CHMP2A
gene id: 9615:CHMP2A
uniprot id: A0A8C0R9T3
uniprot id: A0A8I3MUN9
names: Similarity
messages: Belongs to the SNF7 family.

9615:FUCA1
gene id: 9615:FUCA1
uniprot id: A0A8C0PPZ9
uniprot id: P48300
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Defects in FUCA1 are the cause of fucosidosis. It is a lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues.
messages: Homotetramer.
messages: Lysosome

9615:NSFL1C
gene id: 9615:NSFL1C
uniprot id: A0A8C0T4Z7
uniprot id: A0A8I3NXH4
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9615:CDC25C
gene id: 9615:CDC25C
uniprot id: A0A8C0M853
uniprot id: A0A8I3PBM4
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9615:CREM
gene id: 9615:CREM
uniprot id: P79145
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a dimer. Interacts with FHL5. Interacts with CDC34. May interact with TSSK4.
messages: Nucleus
messages: Stimulated by phosphorylation. Phosphorylated on Ser-118 by TSSK4 in vitro.
messages: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Tau is a transcriptional activator. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity).

9615:IRF2
gene id: 9615:IRF2
uniprot id: A0A8C0NH22
uniprot id: A0A8C0RJR9
uniprot id: A0A8I3NTT7
uniprot id: A0A8I3P574
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:CPSF4
gene id: 9615:CPSF4
uniprot id: A0A8C0QJF2
uniprot id: A0A8I3RSW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9615:PRR15
gene id: 9615:PRR15
uniprot id: A0A8C0Q299
uniprot id: A0A8I3NWA0
names: Similarity
messages: Belongs to the PRR15 family.

9615:PPP3CB
gene id: 9615:PPP3CB
uniprot id: A0A8C0N3J5
uniprot id: A0A8C0PUE7
uniprot id: A0A8I3MW99
uniprot id: A0A8I3N0B2
uniprot id: A0A8I3N5F5
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9615:LETM1
gene id: 9615:LETM1
uniprot id: A0A8C0QFJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:KCNK7
gene id: 9615:KCNK7
uniprot id: A0A8I3P863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:NDUFS5
gene id: 9615:NDUFS5
uniprot id: A0A8C0RXV3
uniprot id: A0A8I3Q2Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9615:AK5
gene id: 9615:AK5
uniprot id: A0A8P0SPG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9615:SLC6A1
gene id: 9615:SLC6A1
uniprot id: A0A8C0MJH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:SLC12A9
gene id: 9615:SLC12A9
uniprot id: A0A8C0RRC1
uniprot id: A0A8P0NFW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

9615:OR11I1
gene id: 9615:OR11I1
uniprot id: A0A8C0NKS3
uniprot id: F1PKK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:TSHR
gene id: 9615:TSHR
uniprot id: P14763
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Glycosylated.
messages: Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production. Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
messages: Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation.

9615:CIAO1
gene id: 9615:CIAO1
uniprot id: A0A8C0N7E3
uniprot id: A0A8I3MTM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9615:THUMPD2
gene id: 9615:THUMPD2
uniprot id: A0A8C0TY28
uniprot id: A0A8I3PJ71
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9615:PHETA2
gene id: 9615:PHETA2
uniprot id: A0A8C0SRM8
uniprot id: A0A8P0PQ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9615:DIP2B
gene id: 9615:DIP2B
uniprot id: A0A8C0PD19
uniprot id: A0A8I3P834
names: Similarity
messages: Belongs to the DIP2 family.

9615:TMEM94
gene id: 9615:TMEM94
uniprot id: A0A8C0PVV6
uniprot id: A0A8C0PWK6
uniprot id: A0A8I3PWE3
names: Subcellular Location Annotation
messages: Membrane

9615:NR2F6
gene id: 9615:NR2F6
uniprot id: A0A8C0YZC3
uniprot id: A0A8I3QQ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:GNAT1
gene id: 9615:GNAT1
uniprot id: Q28300
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity).
messages: Heterotrimeric G proteins are composed of 3 subunits alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RHO. Interacts with RGS9 and PDE6G (By similarity). Interacts (when myristoylated) with UNC119; interaction is required for localization in sensory neurons (By similarity).
messages: Membrane
messages: Photoreceptor inner segment
messages: Rod.
messages: photoreceptor outer segment

9615:ASPDH
gene id: 9615:ASPDH
uniprot id: A0A8C0M414
uniprot id: A0A8I3P030
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9615:CRB1
gene id: 9615:CRB1
uniprot id: A0A8P0ND97
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CAFA-T2R2
gene id: 9615:CAFA-T2R2
uniprot id: Q2ABD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:GJA8
gene id: 9615:GJA8
uniprot id: E2R603
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:QRFP
gene id: 9615:QRFP
uniprot id: A0A8C0Q5Y2
uniprot id: A0A8I3PCK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFamide neuropeptide family.
messages: Secreted

9615:HSD3B7
gene id: 9615:HSD3B7
uniprot id: A0A8C0YWP4
uniprot id: A0A8I3RZP4
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9615:GPN3
gene id: 9615:GPN3
uniprot id: A0A8C0P5Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9615:ZDHHC9
gene id: 9615:ZDHHC9
uniprot id: A0A8C0TA82
uniprot id: A0A8I3QDK9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:LGSN
gene id: 9615:LGSN
uniprot id: Q1ZZS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Dodecamer. Interacts with BFSP2 and VIM.
messages: May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).

9615:ASPN
gene id: 9615:ASPN
uniprot id: A0A8C0M5A4
uniprot id: A0A8I3PJ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9615:ADCY9
gene id: 9615:ADCY9
uniprot id: A0A8C0SNG5
uniprot id: A0A8I3ME97
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9615:SGMS2
gene id: 9615:SGMS2
uniprot id: A0A8C0RT74
uniprot id: A0A8I3S6X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9615:LOC102151831
gene id: 9615:LOC102151831
uniprot id: A0A5F4CZ72
uniprot id: A0A8C0RM64
names: Similarity
messages: Belongs to the KRTAP type 3 family.

9615:NXPH3
gene id: 9615:NXPH3
uniprot id: A0A8C0LV14
uniprot id: A0A8I3N8F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9615:MYOZ3
gene id: 9615:MYOZ3
uniprot id: A0A8C0QHL9
uniprot id: A0A8C0QRR8
uniprot id: A0A8I3MZW2
names: Similarity
messages: Belongs to the myozenin family.

9615:OSGEPL1
gene id: 9615:OSGEPL1
uniprot id: A0A8C0SE93
uniprot id: A0A8P0SEH8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9615:TSPAN32
gene id: 9615:TSPAN32
uniprot id: A0A8I3N985
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:IL29L
gene id: 9615:IL29L
uniprot id: Q1JUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9615:LOC100688697
gene id: 9615:LOC100688697
uniprot id: A0A8C0PJ27
uniprot id: A0A8I3PUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:PRSS2
gene id: 9615:PRSS2
uniprot id: P06872
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: extracellular space

9615:HTATSF1
gene id: 9615:HTATSF1
uniprot id: A0A8I3QS20
names: Similarity
messages: Belongs to the HTATSF1 family.

9615:ORC6
gene id: 9615:ORC6
uniprot id: A0A8C0S415
uniprot id: A0A8I3PA93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9615:C7H18orf21
gene id: 9615:C7H18orf21
uniprot id: A0A8P0NXZ9
names: Similarity
messages: Belongs to the UPF0711 family.

9615:CASP6
gene id: 9615:CASP6
uniprot id: A0A8C0Z5M7
uniprot id: A0A8I3Q9U5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus

9615:WDR48
gene id: 9615:WDR48
uniprot id: A0A8C0N282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Endosome
messages: Late endosome

9615:GJA5
gene id: 9615:GJA5
uniprot id: A0A654IDC7
uniprot id: P33725
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:LOC481187
gene id: 9615:LOC481187
uniprot id: A0A8I3Q3T3
names: Similarity
messages: Belongs to the SCO1/2 family.

9615:SFMBT1
gene id: 9615:SFMBT1
uniprot id: A0A8I3Q269
names: Subcellular Location Annotation
messages: Nucleus

9615:SERPINA4
gene id: 9615:SERPINA4
uniprot id: A0A8C0QCK2
uniprot id: A0A8I3N493
names: Similarity
messages: Belongs to the serpin family.

9615:LPAR1
gene id: 9615:LPAR1
uniprot id: A0A8C0RGT5
uniprot id: A0A8I3NQV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9615:IFT46
gene id: 9615:IFT46
uniprot id: A0A8C0MF20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9615:MED11
gene id: 9615:MED11
uniprot id: A0A8C0MN13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:JPT1
gene id: 9615:JPT1
uniprot id: A0A8C0MCB2
uniprot id: I7KJS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9615:SMC5
gene id: 9615:SMC5
uniprot id: A0A8C0NIZ8
uniprot id: A0A8C0NMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9615:FLNB
gene id: 9615:FLNB
uniprot id: A0A8C0P3R9
uniprot id: A0A8C0PEU4
uniprot id: A0A8C0S7X1
uniprot id: A0A8C0S8F1
uniprot id: A0A8I3PEC3
uniprot id: A0A8I3S4M6
names: Similarity
messages: Belongs to the filamin family.

9615:DYNLT1
gene id: 9615:DYNLT1
uniprot id: A0A8C0NCN5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9615:AWAT1
gene id: 9615:AWAT1
uniprot id: A0A8C0TH09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TERT
gene id: 9615:TERT
uniprot id: Q6A548
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Catalytic component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1. The molecular chaperone HSP90/P23 complex is required for correct assembly and stabilization of the active telomerase. Interacts directly with HSP90A and PTGES3. Interacts with HSPA1A; the interaction occurs in the absence of TERC and dissociates once the complex has formed. Interacts with RAN; the interaction promotes nuclear export of TERT. Interacts with XPO1. Interacts with PTPN11; the interaction retains TERT in the nucleus. Interacts with NCL (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains); the interaction is important for nucleolar localization of TERT (By similarity). Interacts with SMARCA4 (via the bromodomain); the interaction regulates Wnt-mediated signaling (By similarity). Interacts with MCRS1 (isoform MCRS2); the interaction inhibits in vitro telomerase activity (By similarity). Interacts with PIF1; the interaction has no effect on the elongation activity of TERT (By similarity). Interacts with PML; the interaction recruits TERT to PML bodies and inhibits telomerase activity (By similarity). Interacts with GNL3L (By similarity). Interacts with isoform 1 and isoform 2 of NVL (By similarity). Interacts with DHX36 (By similarity). Interacts with ATF7 (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Phosphorylation at Tyr-697 under oxidative stress leads to translocation of TERT to the cytoplasm and reduces its antiapoptotic activity. Dephosphorylated by SHP2/PTPN11 leading to nuclear retention. Phosphorylation at Ser-227 by the AKT pathway promotes nuclear location. Phosphorylation at the G2/M phase at Ser-446 by DYRK2 promotes ubiquitination by the EDVP complex and degradation (By similarity).
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis (By similarity).
messages: The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity (By similarity).
messages: The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.
messages: The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.
messages: Ubiquitinated by the EDVP complex, a E3 ligase complex following phosphorylation at Ser-446 by DYRK2. Ubiquitinated leads to proteasomal degradation (By similarity).
messages: nucleolus
messages: nucleoplasm
messages: telomere

9615:FAM118A
gene id: 9615:FAM118A
uniprot id: A0A8C0S453
uniprot id: A0A8I3NGF4
names: Similarity
messages: Belongs to the FAM118 family.

9615:ATP2C1
gene id: 9615:ATP2C1
uniprot id: A0A8C0M9U3
uniprot id: A0A8C0T8Z0
uniprot id: A0A8I3QH54
uniprot id: A0A8I3QPQ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

9615:TMEFF2
gene id: 9615:TMEFF2
uniprot id: A0A8C0RNL4
uniprot id: A0A8P0NC57
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:FGD2
gene id: 9615:FGD2
uniprot id: A0A8C0MT27
uniprot id: A0A8I3N5A7
names: Subcellular Location Annotation
messages: cytoskeleton

9615:CCND1
gene id: 9615:CCND1
uniprot id: Q64HP0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity (By similarity). Interacts directly with CDKN1B. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with FBXO4 (By similarity). Interacts with UHRF2; the interaction ubiquitinates CCND1 and appears to occur independently of phosphorylation. Interacts with USP2. Interacts (via cyclin N-terminal domain) with INSM1 (via N-terminal region); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and inhibits CDK4 activity. Interacts with CDK4; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex. It also plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex following DNA damage.
messages: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
messages: Ubiquitinated at Lys-270 by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-286 phosphorylation. The DCX(AMBRA1) complex represents the major regulator of CCND1 stability during the G1/S transition (By similarity). Also ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB (By similarity). Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286 phosphorylation. Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization (By similarity).

9615:CSGALNACT1
gene id: 9615:CSGALNACT1
uniprot id: A0A8C0STQ5
uniprot id: A0A8I3NNS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9615:B3GAT1
gene id: 9615:B3GAT1
uniprot id: Q5CB03
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Homodimer. Interacts with SAR1A.
messages: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9615:DMPK
gene id: 9615:DMPK
uniprot id: A0A8I3MRG0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.

9615:SMAD9
gene id: 9615:SMAD9
uniprot id: A0A8C0NHE6
uniprot id: A0A8I3PZR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9615:AASDHPPT
gene id: 9615:AASDHPPT
uniprot id: A0A8C0MMF3
uniprot id: A0A8I3MTD3
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

9615:SLC1A1
gene id: 9615:SLC1A1
uniprot id: Q9N1R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9615:PTPA
gene id: 9615:PTPA
uniprot id: A0A8C0MNR4
uniprot id: A0A8C0S3T6
uniprot id: A0A8I3PGH2
uniprot id: A0A8I3PQ21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9615:KCNC2
gene id: 9615:KCNC2
uniprot id: A0A8C0YWW3
uniprot id: A0A8I3PSN3
uniprot id: A0A8I3S918
names: Subcellular Location Annotation
messages: Membrane

9615:CRHBP
gene id: 9615:CRHBP
uniprot id: A0A8C0N124
uniprot id: A0A8I3RXL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9615:ANO6
gene id: 9615:ANO6
uniprot id: A0A8C0PIR2
uniprot id: A0A8C0TD05
uniprot id: A0A8I3PWU9
uniprot id: A0A8I3Q4Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

9615:INVS
gene id: 9615:INVS
uniprot id: Q6JAN1
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds calmodulin via its IQ domains. Interacts with APC2. Interacts with alpha-, beta-, and gamma-catenin. Interacts with N-cadherin (CDH2). Interacts with NPHP1. Interacts with DVL1, PRICKLE (PRICKLE1 or PRICKLE2) and Strabismus (VANGL1 or VANGL2). Component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3. ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme. Interacts with IQCB1; the interaction likely requires additional interactors (By similarity). Interacts with microtubules.
messages: Hydroxylated at Asn-75, most probably by HIF1AN.
messages: May be ubiquitinated via its interaction with APC2.
messages: Membrane
messages: Nuclear prior to nuclear envelope breakdown. Localizes at the centrosomes in early prophase but in metaphase and anaphase, it localizes to the spindle poles In cells at late telophase undergoing cytokinesis it is detected at the midbody, a region of microtubule overlap (at protein level).
messages: Nucleus
messages: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
messages: The D-box 1 (destruction box 1) mediates the interaction with APC2, and may act as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: cytoskeleton
messages: spindle

9615:SERPINB7
gene id: 9615:SERPINB7
uniprot id: A0A8C0RK04
uniprot id: A0A8I3N155
names: Similarity
messages: Belongs to the serpin family.

9615:RTN4IP1
gene id: 9615:RTN4IP1
uniprot id: A0A8C0MWS4
uniprot id: A0A8I3N5Y1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9615:ATXN1L
gene id: 9615:ATXN1L
uniprot id: A0A8C0MUK5
uniprot id: A0A8I3RUM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9615:L3MBTL2
gene id: 9615:L3MBTL2
uniprot id: A0A8C0T329
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9615:NXF1
gene id: 9615:NXF1
uniprot id: A0A8C0T1C8
uniprot id: A0A8I3N9B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9615:TMEM14A
gene id: 9615:TMEM14A
uniprot id: A0A8C0QBY5
names: Similarity
messages: Belongs to the TMEM14 family.

9615:TAS2R10
gene id: 9615:TAS2R10
uniprot id: Q2ABD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:FLCN
gene id: 9615:FLCN
uniprot id: B1NLQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9615:RPS6KA6
gene id: 9615:RPS6KA6
uniprot id: A0A8I3S3E2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9615:RPN1
gene id: 9615:RPN1
uniprot id: E2RQ08
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:12887896, PubMed:15835887, PubMed:25135935). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:29519914). Interacts with TMEM35A/NACHO (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9615:ILK
gene id: 9615:ILK
uniprot id: A0A8C0NGM4
uniprot id: A0A8P0TU48
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9615:TM9SF2
gene id: 9615:TM9SF2
uniprot id: A0A8C0MI90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9615:EML3
gene id: 9615:EML3
uniprot id: A0A8C0T8M3
uniprot id: A0A8I3RWU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9615:RPN2
gene id: 9615:RPN2
uniprot id: A0A8P0NYL0
uniprot id: F1PCT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:12887896, PubMed:15835887, PubMed:25135935). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:15835887, PubMed:29519914). Interacts with DDI2 (By similarity). Interacts with TMEM35A/NACHO (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9615:ACOT13
gene id: 9615:ACOT13
uniprot id: A0A8C0NJF4
uniprot id: A0A8C0TR50
uniprot id: A0A8I3P1B5
uniprot id: A0A8I3PHE5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9615:GSTCD
gene id: 9615:GSTCD
uniprot id: A0A8C0PFQ6
uniprot id: A0A8I3Q3R9
names: Similarity
messages: Belongs to the GSTCD family.

9615:ACAT2
gene id: 9615:ACAT2
uniprot id: A0A8C0NFX7
uniprot id: A0A8I3N041
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9615:PLK1
gene id: 9615:PLK1
uniprot id: A0A8C0NVZ0
uniprot id: A0A8I3MIN2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9615:DOCK10
gene id: 9615:DOCK10
uniprot id: A0A8C0PB77
uniprot id: A0A8C0SZ31
uniprot id: A0A8C0T4D7
uniprot id: A0A8I3NSC8
uniprot id: A0A8I3NVB3
names: Similarity
messages: Belongs to the DOCK family.

9615:CCL14
gene id: 9615:CCL14
uniprot id: A0A8I3NM26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:PHF5A
gene id: 9615:PHF5A
uniprot id: A0A8C0P813
uniprot id: A0A8I3NSG8
names: Similarity
messages: Belongs to the PHF5 family.

9615:HIF1A
gene id: 9615:HIF1A
uniprot id: A0A8C0QCT6
uniprot id: A0A8I3PI05
uniprot id: Q6SLL1
names: Subcellular Location Annotation
messages: Cytoplasm

9615:LAMP1
gene id: 9615:LAMP1
uniprot id: A0A8C0S792
uniprot id: A0A8I3PPW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9615:BCL2A1
gene id: 9615:BCL2A1
uniprot id: A0A8C0MTY3
names: Similarity
messages: Belongs to the Bcl-2 family.

9615:RHCE
gene id: 9615:RHCE
uniprot id: A0A8C0LVI2
uniprot id: Q3BCQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9615:CASP8
gene id: 9615:CASP8
uniprot id: A0A8C0NB97
uniprot id: Q38JA9
names: Similarity
messages: Belongs to the peptidase C14A family.

9615:SSTR3
gene id: 9615:SSTR3
uniprot id: Q4L144
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:LOC490399
gene id: 9615:LOC490399
uniprot id: A0A8P0SKK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RNASE13
gene id: 9615:RNASE13
uniprot id: W0UVG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9615:FAM83H
gene id: 9615:FAM83H
uniprot id: H6VX52
names: Similarity
messages: Belongs to the FAM83 family.

9615:HNRNPA2B1
gene id: 9615:HNRNPA2B1
uniprot id: A0A8C0QGK5
uniprot id: A0A8I3NCE9
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

9615:TAX1BP3
gene id: 9615:TAX1BP3
uniprot id: A0A8C0MWY5
uniprot id: A0A8I3NPF4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9615:LOC607038
gene id: 9615:LOC607038
uniprot id: A0A8C0M4L8
uniprot id: A0A8I3Q0U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:GLB1L
gene id: 9615:GLB1L
uniprot id: A0A8C0RH93
uniprot id: A0A8I3Q139
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9615:EIF2S1
gene id: 9615:EIF2S1
uniprot id: A0A8C0RLY3
uniprot id: A0A8I3MV19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9615:NICN1
gene id: 9615:NICN1
uniprot id: Q861Y6
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.

9615:BBS5
gene id: 9615:BBS5
uniprot id: A0A8C0TYA2
uniprot id: A0A8I3PED7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9615:HSD17B11
gene id: 9615:HSD17B11
uniprot id: A0A8C0TYF9
uniprot id: A0A8I3NTX0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:ABHD1
gene id: 9615:ABHD1
uniprot id: A0A8I3MTT4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9615:EMX2
gene id: 9615:EMX2
uniprot id: A0A8C0PCR1
uniprot id: A0A8I3QCL1
names: Subcellular Location Annotation
messages: Nucleus

9615:SENP2
gene id: 9615:SENP2
uniprot id: A0A8C0MI94
uniprot id: A0A8I3NZV4
names: Similarity
messages: Belongs to the peptidase C48 family.

9615:WSCD2
gene id: 9615:WSCD2
uniprot id: A0A8C0RU85
uniprot id: A0A8I3PVY6
names: Similarity
messages: Belongs to the WSCD family.

9615:USP4
gene id: 9615:USP4
uniprot id: A0A8C0NH91
uniprot id: A0A8C0NPQ3
uniprot id: A0A8I3PV71
uniprot id: A0A8I3PWL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9615:BEST1
gene id: 9615:BEST1
uniprot id: A0A8C0MI06
uniprot id: A5H7G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9615:GPR161
gene id: 9615:GPR161
uniprot id: A0A8I3MK70
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:CKM
gene id: 9615:CKM
uniprot id: P05123
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Cytoplasm
messages: Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
messages: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

9615:ERO1B
gene id: 9615:ERO1B
uniprot id: A0A8C0MQI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9615:TNNT2
gene id: 9615:TNNT2
uniprot id: A0A8P0TUB7
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9615:ABRACL
gene id: 9615:ABRACL
uniprot id: A0A8C0RA32
uniprot id: A0A8I3RVW1
names: Similarity
messages: Belongs to the costars family.

9615:E2F2
gene id: 9615:E2F2
uniprot id: A0A8I3NKC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9615:LCA5
gene id: 9615:LCA5
uniprot id: A0A8C0MHI8
uniprot id: A0A8I3N1H3
names: Similarity
messages: Belongs to the LCA5 family.

9615:TAS2R41
gene id: 9615:TAS2R41
uniprot id: Q2ABC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:EIF4E3
gene id: 9615:EIF4E3
uniprot id: A0A8I3NIJ6
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9615:LOC100856518
gene id: 9615:LOC100856518
uniprot id: A0A8C0PGI3
uniprot id: A0A8I3PRA4
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9615:VTI1B
gene id: 9615:VTI1B
uniprot id: A0A8C0RLI9
uniprot id: A0A8I3MP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9615:CLDN11
gene id: 9615:CLDN11
uniprot id: A0A8C0SC54
uniprot id: A0A8P0TTF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:KRT89
gene id: 9615:KRT89
uniprot id: A0A8C0PAT3
uniprot id: A0A8P0N9K8
names: Similarity
messages: Belongs to the intermediate filament family.

9615:BCL7C
gene id: 9615:BCL7C
uniprot id: A0A8C0M694
uniprot id: A0A8I3NZ64
names: Similarity
messages: Belongs to the BCL7 family.

9615:INSM2
gene id: 9615:INSM2
uniprot id: A0A8C0MEL2
names: Subcellular Location Annotation
messages: Nucleus

9615:DCP1A
gene id: 9615:DCP1A
uniprot id: A0A8C0PRZ9
uniprot id: A0A8P0T0S1
uniprot id: A0A8P0TKZ1
names: Similarity
messages: Belongs to the DCP1 family.

9615:SCN3B
gene id: 9615:SCN3B
uniprot id: A0A8C0LRA9
uniprot id: A0A8C0S6W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9615:CDC26
gene id: 9615:CDC26
uniprot id: A0A8C0P9T8
uniprot id: A0A8I3N4K8
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9615:SDR16C5
gene id: 9615:SDR16C5
uniprot id: A0A8C0TXX3
uniprot id: A0A8I3S691
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:PFKFB1
gene id: 9615:PFKFB1
uniprot id: A0A8C0TK23
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9615:DCLK1
gene id: 9615:DCLK1
uniprot id: A0A8C0S8G2
uniprot id: A0A8I3QHP2
uniprot id: A0A8I3QQX4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9615:CHMP5
gene id: 9615:CHMP5
uniprot id: A0A8C0MIX2
uniprot id: A0A8P0NS69
names: Similarity
messages: Belongs to the SNF7 family.

9615:SUMO1
gene id: 9615:SUMO1
uniprot id: A0A8C0RNS4
uniprot id: A0A8P0PJL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9615:EGR3
gene id: 9615:EGR3
uniprot id: A0A8C0RPM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9615:KCNS3
gene id: 9615:KCNS3
uniprot id: A0A8C0N799
uniprot id: A0A8I3P439
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:SEC31A
gene id: 9615:SEC31A
uniprot id: A0A8C0N6Z6
uniprot id: A0A8C0N8Y4
uniprot id: A0A8C0Z5D1
uniprot id: A0A8C0Z5E9
uniprot id: A0A8C0Z5G4
uniprot id: A0A8I3P7Z9
uniprot id: A0A8I3S449
uniprot id: A0A8I3S4B6
uniprot id: A0A8P0T620
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:LVRN
gene id: 9615:LVRN
uniprot id: A0A8C0SHL6
uniprot id: A0A8I3MZ41
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9615:RNASE10
gene id: 9615:RNASE10
uniprot id: A0A8C0MLQ2
uniprot id: A0A8P0PPY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9615:LITAF
gene id: 9615:LITAF
uniprot id: A0A8C0Q164
uniprot id: A0A8I3NQ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9615:TMEM211
gene id: 9615:TMEM211
uniprot id: A0A8C0TQI5
uniprot id: A0A8I3Q1T0
names: Subcellular Location Annotation
messages: Membrane

9615:GLIS3
gene id: 9615:GLIS3
uniprot id: A0A8C0N5P6
uniprot id: A0A8I3MG80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9615:PSD
gene id: 9615:PSD
uniprot id: A0A8C0TI68
uniprot id: A0A8I3PZ07
names: Subcellular Location Annotation
messages: ruffle membrane

9615:TNFSF14
gene id: 9615:TNFSF14
uniprot id: A0A8C0P717
uniprot id: J9P753
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:FDFT1
gene id: 9615:FDFT1
uniprot id: A0A8C0NTL6
uniprot id: A0A8C0TGW2
uniprot id: A0A8I3P3D2
uniprot id: A0A8I3P8C5
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9615:PSMB6
gene id: 9615:PSMB6
uniprot id: A0A8C0MYP5
uniprot id: A0A8I3RT39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:ATP8B1
gene id: 9615:ATP8B1
uniprot id: A0A8C0MJZ1
uniprot id: A0A8C0RZS9
uniprot id: A0A8I3MQM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:RAG1
gene id: 9615:RAG1
uniprot id: A0A8C0SIL6
uniprot id: A0A8I3PC48
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.
messages: Homodimer.
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.

9615:RBM22
gene id: 9615:RBM22
uniprot id: A0A8C0M1Y1
uniprot id: A0A8I3RTA4
names: Similarity
messages: Belongs to the SLT11 family.

9615:HNF1B
gene id: 9615:HNF1B
uniprot id: A0A8C0P2E8
uniprot id: A0A8I3N7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9615:TSNAX
gene id: 9615:TSNAX
uniprot id: A0A8C0Q058
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9615:PKN1
gene id: 9615:PKN1
uniprot id: A0A8P0TA01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9615:TAF9
gene id: 9615:TAF9
uniprot id: A0A8I3RX25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9615:LMX1A
gene id: 9615:LMX1A
uniprot id: A0A8C0P6V3
uniprot id: A0A8I3PJV5
names: Subcellular Location Annotation
messages: Nucleus

9615:MIX23
gene id: 9615:MIX23
uniprot id: A0A8C0TKH2
names: Similarity
messages: Belongs to the MIX23 family.

9615:LAMC2
gene id: 9615:LAMC2
uniprot id: Q867A2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9615:SEC16B
gene id: 9615:SEC16B
uniprot id: A0A8C0QG11
uniprot id: A0A8P0NNG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

9615:PCK1
gene id: 9615:PCK1
uniprot id: A0A8C0PGX6
uniprot id: A0A8I3QWQ0
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9615:POLR3K
gene id: 9615:POLR3K
uniprot id: A0A8C0RM35
uniprot id: A0A8I3RPT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9615:KCNK2
gene id: 9615:KCNK2
uniprot id: A0A8C0MBK2
uniprot id: A0A8C0PVA0
uniprot id: A0A8C0Q4T2
uniprot id: A0A8P0NEL3
uniprot id: A0A8P0SXT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:ST6GALNAC2
gene id: 9615:ST6GALNAC2
uniprot id: A0A8C0Q6J7
uniprot id: Q00M94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:PSMA6
gene id: 9615:PSMA6
uniprot id: A0A8C0RDG3
uniprot id: A0A8C0SR54
uniprot id: A0A8I3MJ89
uniprot id: A0A8I3N0P1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9615:H1-10
gene id: 9615:H1-10
uniprot id: A0A8C0TZ50
uniprot id: A0A8I3P7C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9615:TRDN
gene id: 9615:TRDN
uniprot id: P82179
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
messages: Detected in heart (at protein level). Skeletal and cardiac muscle.
messages: Homooligomer of variable subunit number; disulfide-linked. Interacts with CASQ1 and RYR1 in skeletal muscle (By similarity). Interacts with CASQ2.
messages: N-glycosylated.
messages: Phosphorylated by CaMK2.
messages: Sarcoplasmic reticulum membrane

9615:HR
gene id: 9615:HR
uniprot id: A0A8I3QB60
names: Subcellular Location Annotation
messages: Nucleus

9615:MPP7
gene id: 9615:MPP7
uniprot id: A0A8C0MPG3
uniprot id: A0A8C0MYQ1
uniprot id: A0A8I3N9S4
uniprot id: A0A8I3NH36
uniprot id: A0A8I3RZ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: adherens junction
messages: tight junction

9615:TPH2
gene id: 9615:TPH2
uniprot id: B6EY12
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9615:FMO4
gene id: 9615:FMO4
uniprot id: A0A8I3MFK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:ETFDH
gene id: 9615:ETFDH
uniprot id: A0A8C0MFJ0
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9615:CAMK2G
gene id: 9615:CAMK2G
uniprot id: A0A8C0PS45
uniprot id: A0A8C0PSP6
uniprot id: A0A8C0PT65
uniprot id: A0A8C0PYR2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9615:TDRD5
gene id: 9615:TDRD5
uniprot id: A0A8P0SIS1
uniprot id: A0A8P0TFP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.

9615:PC
gene id: 9615:PC
uniprot id: A0A8I3NKZ1
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

9615:LPL
gene id: 9615:LPL
uniprot id: A0A8C0TU24
uniprot id: A0A8I3Q1E8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9615:HNRNPH1
gene id: 9615:HNRNPH1
uniprot id: A0A8C0MEB5
uniprot id: A0A8C0MIY8
uniprot id: A0A8I3N686
uniprot id: A0A8I3NJT6
names: Subcellular Location Annotation
messages: nucleoplasm

9615:C7H1orf43
gene id: 9615:C7H1orf43
uniprot id: A0A8P0SLK3
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9615:BATF
gene id: 9615:BATF
uniprot id: A0A8C0NRC2
uniprot id: A0A8I3P059
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9615:DIS3
gene id: 9615:DIS3
uniprot id: A0A8C0QES1
uniprot id: A0A8C0RZM7
uniprot id: A0A8I3PF99
uniprot id: A0A8I3PG95
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9615:PSMD3
gene id: 9615:PSMD3
uniprot id: A0A8C0PP61
uniprot id: A0A8I3NH42
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9615:GAP43
gene id: 9615:GAP43
uniprot id: A0A8C0RTG5
uniprot id: A0A8I3NKU6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9615:PPP1R15B
gene id: 9615:PPP1R15B
uniprot id: A0A8I3PLL5
names: Similarity
messages: Belongs to the PPP1R15 family.

9615:CD36
gene id: 9615:CD36
uniprot id: A0A8C0MYI3
uniprot id: D5IGC7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

9615:CDH1
gene id: 9615:CDH1
uniprot id: F1PAA9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
messages: Cell membrane
messages: During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 (By similarity). Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm (By similarity). The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway (By similarity). Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system (By similarity). The gamma-secretase-mediated cleavage promotes disassembly of adherens junctions (By similarity). During development of the cochlear organ of Corti, cleavage by ADAM10 at adherens junctions promotes pillar cell separation (By similarity).
messages: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
messages: Endosome
messages: Homodimer; disulfide-linked (By similarity). Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1; the complex is located to adherens junctions (By similarity). Interacts with the TRPV4 and CTNNB1 complex (By similarity). Interacts with CTNND1 (By similarity). The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex (By similarity). Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1 (By similarity). Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs) (By similarity). Interacts with AJAP1 and DLGAP5 (By similarity). Interacts with TBC1D2 (By similarity). Interacts with LIMA1 (By similarity). Interacts with CAV1 (By similarity). Interacts with PIP5K1C (By similarity). Interacts with RAB8B (By similarity). Interacts with DDR1; this stabilizes CDH1 at the cell surface and inhibits its internalization (By similarity). Interacts with RAPGEF2 (PubMed:10873669). Interacts with KLRG1 (By similarity). Forms a ternary complex composed of ADAM10, CADH1 and EPHA4; within the complex, CADH1 is cleaved by ADAM10 which disrupts adherens junctions (By similarity). Interacts with SPEF1 (By similarity). Interacts with CTNNB1 and PKP2 (By similarity).
messages: N-glycosylation at Asn-639 is essential for expression, folding and trafficking. Addition of bisecting N-acetylglucosamine by MGAT3 modulates its cell membrane location (By similarity).
messages: O-glycosylated. O-manosylated by TMTC1, TMTC2, TMTC3 or TMTC4. Thr-287 and Thr-511 are O-mannosylated by TMTC2 or TMTC4 but not TMTC1 or TMTC3.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
messages: Ubiquitinated by a SCF complex containing SKP2, which requires prior phosphorylation by CK1/CSNK1A1. Ubiquitinated by CBLL1/HAKAI, requires prior phosphorylation at Tyr-757 (By similarity).
messages: adherens junction
messages: trans-Golgi network

9615:ATP6V0C
gene id: 9615:ATP6V0C
uniprot id: A0A8C0Z2A2
uniprot id: A0A8I3RRR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9615:MAP1LC3B
gene id: 9615:MAP1LC3B
uniprot id: A0A8C0NNB2
names: Similarity
messages: Belongs to the ATG8 family.

9615:F10
gene id: 9615:F10
uniprot id: A0A8C0S4C1
uniprot id: A0A8I3PQV5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:MS4A13
gene id: 9615:MS4A13
uniprot id: A0A8I3NW89
names: Similarity
messages: Belongs to the MS4A family.

9615:ITK
gene id: 9615:ITK
uniprot id: A0A8C0N2M8
uniprot id: A0A8I3MMK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:PCYT1A
gene id: 9615:PCYT1A
uniprot id: A0A8C0P1R7
uniprot id: A0A8I3Q529
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9615:TMA16
gene id: 9615:TMA16
uniprot id: A0A8C0RYS1
uniprot id: A0A8I3RTD2
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9615:CDK14
gene id: 9615:CDK14
uniprot id: A0A8C0SUP7
uniprot id: A0A8I3NJK4
uniprot id: A0A8I3NKI6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:LOC479761
gene id: 9615:LOC479761
uniprot id: A0A8I3NMX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:A4GALT
gene id: 9615:A4GALT
uniprot id: A0A8I3NTR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9615:TPM2
gene id: 9615:TPM2
uniprot id: A0A8C0MXG3
uniprot id: A0A8C0N098
uniprot id: A0A8C0N3P5
uniprot id: A0A8I3N002
uniprot id: A0A8I3NAC0
uniprot id: A0A8I3RWJ7
uniprot id: E2RAH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9615:FAM214A
gene id: 9615:FAM214A
uniprot id: A0A8C0TYB5
uniprot id: A0A8P0P609
names: Similarity
messages: Belongs to the FAM214 family.

9615:ACLY
gene id: 9615:ACLY
uniprot id: A0A8C0NV54
uniprot id: A0A8C0S3J8
uniprot id: A0A8I3NHY9
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9615:TGM2
gene id: 9615:TGM2
uniprot id: A0A8I3PZ15
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9615:SLC29A2
gene id: 9615:SLC29A2
uniprot id: A0A8C0NPU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9615:DYNC1LI1
gene id: 9615:DYNC1LI1
uniprot id: A0A8C0NNW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9615:DSG1
gene id: 9615:DSG1
uniprot id: Q9GKQ8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to JUP/plakoglobin (By similarity). Interacts with PKP2 (By similarity).
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
messages: desmosome

9615:CCNH
gene id: 9615:CCNH
uniprot id: A0A8C0MQJ3
uniprot id: A0A8I3P7T2
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9615:B4GALT2
gene id: 9615:B4GALT2
uniprot id: A0A8C0NFM5
uniprot id: A0A8I3Q406
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9615:EXTL2
gene id: 9615:EXTL2
uniprot id: A0A8C0NPH0
uniprot id: A0A8C0PZY2
uniprot id: A0A8I3NG09
uniprot id: A0A8I3NML7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:LOC486776
gene id: 9615:LOC486776
uniprot id: A0A8C0P500
uniprot id: A0A8I3PN69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9615:PKLR
gene id: 9615:PKLR
uniprot id: Q29536
names: Activity Regulation
names: Disease Annotation
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate.
messages: Belongs to the pyruvate kinase family.
messages: Defects in PKLR are a cause of inherited hemolytic anemia, an autosomal recessive disease of the Basenji dog that closely resembles human pyruvate kinase deficiency.
messages: Derived from EST data.
messages: Homotetramer.
messages: Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis.
messages: There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues.

9615:STK32B
gene id: 9615:STK32B
uniprot id: A0A8C0M072
uniprot id: A0A8I3MP15
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:NONO
gene id: 9615:NONO
uniprot id: A0A8C0NGA6
names: Subcellular Location Annotation
messages: Nucleus speckle

9615:COPS5
gene id: 9615:COPS5
uniprot id: A0A8C0RIF2
uniprot id: A0A8I3PK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9615:RBM8A
gene id: 9615:RBM8A
uniprot id: A0A8C0MAY3
uniprot id: A0A8I3NI72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9615:GPC5
gene id: 9615:GPC5
uniprot id: A0A8C0NJF1
uniprot id: A0A8P0SAY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9615:PNOC
gene id: 9615:PNOC
uniprot id: A0A8C0SZ80
uniprot id: A0A8I3MYM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9615:KIF21B
gene id: 9615:KIF21B
uniprot id: A0A8C0PE69
uniprot id: A0A8I3PAJ6
uniprot id: A0A8P0TH17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

9615:RAB38
gene id: 9615:RAB38
uniprot id: A0A8C0MYY6
uniprot id: A0A8P0PHI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9615:AGAP1
gene id: 9615:AGAP1
uniprot id: A0A8C0P9T2
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9615:GSK3B
gene id: 9615:GSK3B
uniprot id: A0A8C0MPF2
uniprot id: A0A8C0T8A0
uniprot id: A0A8P0NMG8
uniprot id: A0A8P0PIC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

9615:GPC4
gene id: 9615:GPC4
uniprot id: A0A8C0TLM2
uniprot id: A0A8I3QZP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9615:MAPK14
gene id: 9615:MAPK14
uniprot id: O02812
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC3 (By similarity).
messages: Activated by cell stresses such as DNA damage, heat shock, osmotic shock, anisomycin and sodium arsenite, as well as pro-inflammatory stimuli such as bacterial lipopolysaccharide (LPS) and interleukin-1. Activation occurs through dual phosphorylation of Thr-180 and Tyr-182 by either of two dual specificity kinases, MAP2K3/MKK3 or MAP2K6/MKK6, and potentially also MAP2K4/MKK4, as well as by TAB1-mediated autophosphorylation. MAPK14 phosphorylated on both Thr-180 and Tyr-182 is 10-20-fold more active than MAPK14 phosphorylated only on Thr-180, whereas MAPK14 phosphorylated on Tyr-182 alone is inactive. whereas Thr-180 is necessary for catalysis, Tyr-182 may be required for auto-activation and substrate recognition. Phosphorylated at Tyr-323 by ZAP70 in an alternative activation pathway in response to TCR signaling in T-cells. This alternative pathway is inhibited by GADD45A. Inhibited by dual specificity phosphatases, such as DUSP1, DUSP10, and DUSP16. Specifically inhibited by the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID). SB203580 is an inhibitor of MAPK14 (By similarity).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (By similarity). Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1. Interacts with casein kinase II subunits CSNK2A1 and CSNK2B. Interacts with PPM1D. Interacts with CDK5RAP3; recruits PPM1D to MAPK14 and may regulate its dephosphorylation (By similarity). Interacts with DUSP2; this interaction does not lead to catalytic activation of DUSP2 and dephosphrylation of MAPK14 (By similarity).
messages: Cytoplasm
messages: Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323 phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16 (By similarity). PPM1D also mediates dephosphorylation and inactivation of MAPK14 (By similarity).
messages: Nucleus
messages: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulatin…
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
messages: Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway (By similarity).

9615:CHRM3
gene id: 9615:CHRM3
uniprot id: A0A8C0RUM6
uniprot id: A0A8I3N190
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9615:CLCN4
gene id: 9615:CLCN4
uniprot id: A0A8C0YYL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9615:VIPR1
gene id: 9615:VIPR1
uniprot id: A0A8C0SRJ5
uniprot id: A0A8I3S164
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9615:PDYN
gene id: 9615:PDYN
uniprot id: A0A8C0MLA4
uniprot id: A0A8I3P0A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
messages: Secreted

9615:LIPJ
gene id: 9615:LIPJ
uniprot id: A0A8C0P5T9
uniprot id: A0A8P0SPV6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9615:LOC610578
gene id: 9615:LOC610578
uniprot id: A0A8P0NQ22
uniprot id: A0A8P0S8N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9615:CRSP-2
gene id: 9615:CRSP-2
uniprot id: Q75V93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted

9615:PPM1D
gene id: 9615:PPM1D
uniprot id: A0A8C0RSS8
names: Similarity
messages: Belongs to the PP2C family.

9615:RELL2
gene id: 9615:RELL2
uniprot id: A0A8C0QAB7
uniprot id: A0A8P0N8N6
names: Similarity
messages: Belongs to the RELT family.

9615:EPHB4
gene id: 9615:EPHB4
uniprot id: A0A8C0SDG2
uniprot id: A0A8I3MBN5
names: Subcellular Location Annotation
messages: Membrane

9615:EXOC5
gene id: 9615:EXOC5
uniprot id: A0A8C0Q1Y6
uniprot id: A0A8I3PAA1
names: Function
names: Similarity
messages: Belongs to the SEC10 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9615:VN1R4
gene id: 9615:VN1R4
uniprot id: A0A8C0LU24
uniprot id: Q8MIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:ELMO3
gene id: 9615:ELMO3
uniprot id: A0A8C0T023
uniprot id: A0A8I3N1G7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9615:TMEM242
gene id: 9615:TMEM242
uniprot id: A0A8C0T4M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9615:GNB2
gene id: 9615:GNB2
uniprot id: A0A8C0PFT1
uniprot id: A0A8I3ME07
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9615:SMG8
gene id: 9615:SMG8
uniprot id: A0A8C0MJW9
uniprot id: A0A8I3PWU0
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

9615:BZW2
gene id: 9615:BZW2
uniprot id: A0A8I3NCC5
names: Similarity
messages: Belongs to the BZW family.

9615:TXLNG
gene id: 9615:TXLNG
uniprot id: A0A8C0NIZ1
names: Similarity
messages: Belongs to the taxilin family.

9615:ABO
gene id: 9615:ABO
uniprot id: A0A8C0PMD0
uniprot id: F1PEJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9615:ARHGEF7
gene id: 9615:ARHGEF7
uniprot id: A0A8C0PFG5
uniprot id: A0A8I3PIX8
names: Subcellular Location Annotation
messages: lamellipodium

9615:TMEM205
gene id: 9615:TMEM205
uniprot id: A0A8C0P6U5
uniprot id: A0A8I3S124
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9615:BFSP1
gene id: 9615:BFSP1
uniprot id: A0A8C0PHQ1
uniprot id: A0A8I3NXF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

9615:DHRS7B
gene id: 9615:DHRS7B
uniprot id: A0A8C0M541
uniprot id: A0A8C0Q094
uniprot id: A0A8P0PRV0
uniprot id: A0A8P0SMW6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:VCAN
gene id: 9615:VCAN
uniprot id: A0A8P0NAS1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:CAST
gene id: 9615:CAST
uniprot id: A0A8P0NAE9
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9615:PAMR1
gene id: 9615:PAMR1
uniprot id: A0A8C0PE44
uniprot id: A0A8P0TC77
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TMED7
gene id: 9615:TMED7
uniprot id: A0A8C0YWU4
uniprot id: A0A8I3MVE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9615:NOL8
gene id: 9615:NOL8
uniprot id: A0A8C0LUL8
names: Subcellular Location Annotation
messages: nucleolus

9615:ADGRF2
gene id: 9615:ADGRF2
uniprot id: A0A8C0YYS3
uniprot id: A0A8I3RXN9
names: Subcellular Location Annotation
messages: Membrane

9615:PFKL
gene id: 9615:PFKL
uniprot id: A0A8C0PFZ8
uniprot id: A0A8I3PBD8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SEC11A
gene id: 9615:SEC11A
uniprot id: P67811
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473, PubMed:8444896, PubMed:14559916). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SPCS2 and SPCS3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: The C-terminal short (CTS) helix is essential for catalytic activity (By similarity). It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates (By similarity).

9615:FAM162B
gene id: 9615:FAM162B
uniprot id: A0A8C0Q5F8
uniprot id: A0A8I3MUH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9615:NAP1L2
gene id: 9615:NAP1L2
uniprot id: A0A8C0SHX1
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:LOC612537
gene id: 9615:LOC612537
uniprot id: A0A8I3MWB9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:SCARA5
gene id: 9615:SCARA5
uniprot id: A0A8C0PKL5
uniprot id: A0A8I3NCP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9615:MSR1
gene id: 9615:MSR1
uniprot id: A0A8C0Q7U5
uniprot id: A0A8I3NVT5
names: Subcellular Location Annotation
messages: Membrane

9615:KRT1
gene id: 9615:KRT1
uniprot id: Q6EIY9
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Heterotetramer of two type I and two type II keratins (By similarity). Heterodimer with KRT10 (By similarity). Two heterodimers of KRT1 and KRT10 form a heterotetramer (By similarity). Forms a heterodimer with KRT14; the interaction is more abundant in the absence of KRT5 (By similarity). Interacts with ITGB1 in the presence of RACK1 and SRC, and with RACK1 (By similarity). Interacts with C1QBP; the association represents a cell surface kininogen receptor (By similarity). Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament (By similarity).
messages: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity).
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
messages: Undergoes deimination of some arginine residues (citrullination).

9615:LOC477556
gene id: 9615:LOC477556
uniprot id: A0A8C0RRF0
uniprot id: A0A8P0P9S7
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

9615:TBX15
gene id: 9615:TBX15
uniprot id: A0A8C0SKN9
uniprot id: A0A8P0PCY8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:RPL18A
gene id: 9615:RPL18A
uniprot id: A0A8C0NQB7
uniprot id: A0A8I3PMS5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9615:CD40LG
gene id: 9615:CD40LG
uniprot id: A0A0U5J6Y6
uniprot id: O97626
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Homotrimer.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9615:CDSN
gene id: 9615:CDSN
uniprot id: A0A8C0MH70
uniprot id: A0A8I3MP57
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9615:NTRK2
gene id: 9615:NTRK2
uniprot id: A0A8C0PN47
uniprot id: A0A8C0PPL3
uniprot id: A0A8I3MQS1
uniprot id: A0A8I3RSL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:DLAT
gene id: 9615:DLAT
uniprot id: A0A8C0NAN7
uniprot id: A0A8I3MZS6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9615:SGF29
gene id: 9615:SGF29
uniprot id: A0A8C0PM93
uniprot id: A0A8I3MF38
names: Subcellular Location Annotation
messages: Nucleus

9615:HNRNPDL
gene id: 9615:HNRNPDL
uniprot id: A0A8C0NFT1
uniprot id: A0A8I3NY09
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:KCNJ4
gene id: 9615:KCNJ4
uniprot id: A0A8C0NF94
uniprot id: A0A8P0S7M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9615:AP3D1
gene id: 9615:AP3D1
uniprot id: A0A8C0N252
uniprot id: A0A8I3NYV5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9615:TGFBR2
gene id: 9615:TGFBR2
uniprot id: A0A8C0RMM0
uniprot id: A0A8I3PL32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

9615:SLC15A4
gene id: 9615:SLC15A4
uniprot id: A0A8I3QXL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

9615:POLR3G
gene id: 9615:POLR3G
uniprot id: A0A8C0PUJ9
uniprot id: A0A8I3RZE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9615:PPP1R15A
gene id: 9615:PPP1R15A
uniprot id: A0A8I3MI88
names: Similarity
messages: Belongs to the PPP1R15 family.

9615:LMF1
gene id: 9615:LMF1
uniprot id: A0A8C0NE39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

9615:IP6K2
gene id: 9615:IP6K2
uniprot id: A0A8C0RMR4
uniprot id: A0A8I3Q347
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9615:CYP21A2
gene id: 9615:CYP21A2
uniprot id: Q9N2C7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:TAF1B
gene id: 9615:TAF1B
uniprot id: A0A8C0RD09
uniprot id: A0A8I3PUY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

9615:KCNV1
gene id: 9615:KCNV1
uniprot id: A0A8C0SFJ0
uniprot id: A0A8I3NTA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9615:OAZ2
gene id: 9615:OAZ2
uniprot id: A0A8C0NKF9
uniprot id: A0A8I3PNL0
names: Similarity
messages: Belongs to the ODC antizyme family.

9615:DTX2
gene id: 9615:DTX2
uniprot id: A0A8C0MR52
uniprot id: A0A8I3RTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9615:CYB5R2
gene id: 9615:CYB5R2
uniprot id: A0A8I3RYD7
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9615:ADGRB2
gene id: 9615:ADGRB2
uniprot id: A0A8C0P2Y3
uniprot id: A0A8C0RQ00
uniprot id: A0A8C0TIX1
uniprot id: A0A8C0TK70
uniprot id: A0A8C0TKI9
uniprot id: A0A8C0TKW2
uniprot id: A0A8I3MP07
names: Subcellular Location Annotation
messages: Membrane

9615:FBN1
gene id: 9615:FBN1
uniprot id: A0A8C0T391
uniprot id: A0A8P0NG90
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:CLRN3
gene id: 9615:CLRN3
uniprot id: A0A8C0TIZ8
uniprot id: A0A8I3Q646
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9615:ASPH
gene id: 9615:ASPH
uniprot id: Q28264
names: Subcellular Location Annotation
messages: Membrane

9615:MYOF
gene id: 9615:MYOF
uniprot id: A0A8C0RIJ4
uniprot id: A0A8I3PC83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9615:BST1
gene id: 9615:BST1
uniprot id: A0A8C0SEW4
uniprot id: A0A8P0SJP8
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9615:B3GNT3
gene id: 9615:B3GNT3
uniprot id: A0A8P0NGP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:SS18
gene id: 9615:SS18
uniprot id: A0A8C0SS18
uniprot id: A0A8C0ST09
uniprot id: A0A8I3NCX9
uniprot id: A0A8I3NQC6
uniprot id: A0A8I3RXA5
names: Similarity
messages: Belongs to the SS18 family.

9615:FBLN7
gene id: 9615:FBLN7
uniprot id: A0A8C0SBQ9
uniprot id: A0A8I3ND89
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:YWHAH
gene id: 9615:YWHAH
uniprot id: A0A8C0PKM7
uniprot id: A0A8I3S659
names: Similarity
messages: Belongs to the 14-3-3 family.

9615:HOMER1
gene id: 9615:HOMER1
uniprot id: A0A8C0NFB8
uniprot id: A0A8I3RUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9615:CLPS
gene id: 9615:CLPS
uniprot id: P19090
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the colipase family.
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Expressed by the pancreas.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9615:RBPMS2
gene id: 9615:RBPMS2
uniprot id: A0A8C0NWS3
uniprot id: A0A8I3PFA2
uniprot id: A0A8I3S3S2
names: Subcellular Location Annotation
messages: Cytoplasm

9615:PDHX
gene id: 9615:PDHX
uniprot id: A0A8C0YZW1
uniprot id: A0A8I3S3H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9615:MYH11
gene id: 9615:MYH11
uniprot id: A0A8C0NKX8
uniprot id: A0A8C0NTR6
uniprot id: A0A8C0PT46
uniprot id: A0A8I3N4Q0
uniprot id: A0A8I3N9H0
uniprot id: A0A8I3RUP6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9615:TMTC2
gene id: 9615:TMTC2
uniprot id: A0A8C0NX25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9615:MGST1
gene id: 9615:MGST1
uniprot id: A0A8C0PVU2
uniprot id: A0A8I3P4R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9615:NTS
gene id: 9615:NTS
uniprot id: P10673
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neurotensin family.
messages: Interacts with NTSR1. Interacts with SORT1. Interacts with SORL1.
messages: Neurotensin is cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: secretory vesicle

9615:PIGV
gene id: 9615:PIGV
uniprot id: A0A8C0N3Z9
uniprot id: A0A8I3NIX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9615:NPPB
gene id: 9615:NPPB
uniprot id: A0A8P0PRD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.
messages: Secreted

9615:ATP5ME
gene id: 9615:ATP5ME
uniprot id: A0A8C0S458
uniprot id: A0A8I3Q3D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9615:MTIF2
gene id: 9615:MTIF2
uniprot id: A0A8C0RTA4
uniprot id: A0A8I3NSU9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9615:BARHL2
gene id: 9615:BARHL2
uniprot id: A0A8P0SP23
names: Subcellular Location Annotation
messages: Nucleus

9615:MAPK6
gene id: 9615:MAPK6
uniprot id: A0A8C0TRN7
uniprot id: A0A8P0SQ67
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9615:TNFSF4
gene id: 9615:TNFSF4
uniprot id: A0A8C0SEP3
uniprot id: E2RP79
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:FKBP4
gene id: 9615:FKBP4
uniprot id: A0A8C0PH91
uniprot id: E2QWF5
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Nucleus
messages: cytoskeleton
messages: cytosol

9615:PPOX
gene id: 9615:PPOX
uniprot id: A0A8C0SK32
uniprot id: A0A8P0NEL6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9615:SGIP1
gene id: 9615:SGIP1
uniprot id: A0A8C0M810
uniprot id: A0A8I3PZ29
names: Function
names: Subcellular Location Annotation
messages: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
messages: clathrin-coated pit

9615:NPR1
gene id: 9615:NPR1
uniprot id: A0A8C0RWY3
uniprot id: A0A8I3MHU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9615:CMTM2
gene id: 9615:CMTM2
uniprot id: A0A8C0N444
uniprot id: A0A8I3NGD1
names: Subcellular Location Annotation
messages: Membrane

9615:VASP
gene id: 9615:VASP
uniprot id: P50551
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Ena/VASP family.
messages: Cytoplasm
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity).
messages: Homotetramer. Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1 domain, with the Pro-rich regions of ZYX. This interaction is important for targeting to focal adhesions and the formation of actin-rich structures at the apical surface of cells. Interacts, via the EVH1 domain, with the Pro-rich domain of Listeria monocytogenes actA. Interacts with APBB1IP. Interacts, via the Pro-rich domain, with the C-terminal SH3 domain of DNMBP. Interacts weakly with MEFV (By similarity).
messages: Major substrate for cAMP-dependent (PKA) and cGMP-dependent protein kinase (PKG) in platelets. The preferred site for PKA is Ser-160, the preferred site for PKG/PRKG1, Ser-242. In ADP-activated platelets, phosphorylation by PKA or PKG on Ser-160 leads to fibrinogen receptor inhibition. Phosphorylation on Thr-281 requires prior phosphorylation on Ser-160 and Ser-242. In response to phorbol ester (PMA) stimulation, phosphorylated by PKC/PRKCA. In response to thrombin, phosphorylated by both PKC and ROCK1. Phosphorylation at Thr-281 by AMPK does not require prior phosphorylation at Ser-160 or Ser-242. Phosphorylation at Ser-160 by PKA is required for localization to the tight junctions in epithelial cells. Phosphorylation modulates F-actin binding, actin filament elongation and platelet activation. Phosphorylation at Ser-326 by AMPK also alters actin filament binding. Carbon monoxide (CO) promotes phosphorylation at Ser-160, while nitric oxide (NO) promotes phosphorylation at Ser-160, but also at Ser-242 (By similarity).
messages: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.
messages: The WH1 domain mediates interaction with XIRP1.
messages: cytoskeleton
messages: filopodium membrane
messages: focal adhesion
messages: lamellipodium membrane
messages: tight junction

9615:VAT1
gene id: 9615:VAT1
uniprot id: A0A8C0LX65
uniprot id: A0A8I3RT77
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9615:SENP5
gene id: 9615:SENP5
uniprot id: A0A8I3QXM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9615:DUSP10
gene id: 9615:DUSP10
uniprot id: A0A8C0PG26
uniprot id: A0A8I3Q914
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9615:SLC44A5
gene id: 9615:SLC44A5
uniprot id: A0A8C0NPM6
uniprot id: A0A8I3MUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9615:TACO1
gene id: 9615:TACO1
uniprot id: A0A8C0N9V5
uniprot id: A0A8I3PDU7
names: Similarity
messages: Belongs to the TACO1 family.

9615:SMU1
gene id: 9615:SMU1
uniprot id: A0A8P0NSV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9615:OR9A4
gene id: 9615:OR9A4
uniprot id: F1PI02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ASIC2
gene id: 9615:ASIC2
uniprot id: A0A8C0SC49
uniprot id: A0A8C0SCD1
uniprot id: A0A8I3NDS2
uniprot id: A0A8I3NHZ8
names: Subcellular Location Annotation
messages: Membrane

9615:LOC607080
gene id: 9615:LOC607080
uniprot id: A0A8C0M5Q4
uniprot id: A0A8I3QSA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9615:ELOC
gene id: 9615:ELOC
uniprot id: A0A8C0SXC4
uniprot id: A0A8I3PYQ7
names: Similarity
messages: Belongs to the SKP1 family.

9615:SPP1
gene id: 9615:SPP1
uniprot id: A0A8P0NMW9
uniprot id: A0A8P0NUY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

9615:VAMP3
gene id: 9615:VAMP3
uniprot id: A0A8C0SD59
uniprot id: A0A8I3PT55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9615:RNMT
gene id: 9615:RNMT
uniprot id: A0A8C0SFE4
uniprot id: A0A8I3RRE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9615:ING4
gene id: 9615:ING4
uniprot id: A0A8C0PKT4
uniprot id: A0A8P0T4X6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9615:HOXA3
gene id: 9615:HOXA3
uniprot id: A0A8C0RDC5
uniprot id: A0A8I3NKF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:OR2B11
gene id: 9615:OR2B11
uniprot id: A0A8P0NCS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ARL4D
gene id: 9615:ARL4D
uniprot id: A0A8C0T404
uniprot id: A0A8I3NH73
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9615:PTGR1
gene id: 9615:PTGR1
uniprot id: A0A8C0MR59
uniprot id: A0A8I3MRC0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9615:AP4S1
gene id: 9615:AP4S1
uniprot id: A0A8C0SCI6
uniprot id: A0A8I3NG40
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9615:UFD1
gene id: 9615:UFD1
uniprot id: A0A8C0TI19
uniprot id: A0A8I3S770
names: Similarity
messages: Belongs to the UFD1 family.

9615:PDCD10
gene id: 9615:PDCD10
uniprot id: A0A8C0S1G8
uniprot id: A0A8I3PGJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9615:HNRNPUL2
gene id: 9615:HNRNPUL2
uniprot id: A0A8C0T321
uniprot id: A0A8I3N8E9
names: Subcellular Location Annotation
messages: Nucleus

9615:ATP1A1
gene id: 9615:ATP1A1
uniprot id: P50997
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Melanosome
messages: Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-941 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1 (PubMed:16943195, PubMed:21454534). Interacts with regulatory subunit FXYD3 (By similarity). Interacts with SIK1 (By similarity). Interacts with SLC35G1 and STIM1 (By similarity). Interacts with CLN3; this interaction regulates the sodium/potassium-transporting ATPase complex localization at the plasma membrane (By similarity).
messages: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
messages: axon
messages: sarcolemma

9615:PIK3CA
gene id: 9615:PIK3CA
uniprot id: A0A5F4C2B1
uniprot id: A0A8C0T7K1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9615:CENPJ
gene id: 9615:CENPJ
uniprot id: A0A8C0SUP5
uniprot id: A0A8P0N9V0
names: Similarity
messages: Belongs to the TCP10 family.

9615:MRPL16
gene id: 9615:MRPL16
uniprot id: A0A8C0PZ41
uniprot id: A0A8I3PA59
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9615:CLU
gene id: 9615:CLU
uniprot id: P25473
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 and PON1. Interacts with the complement complex. Interacts (via alpha chain) with XRCC6. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not interact with BAX in unstressed cells. Found in a complex with LTF, CLU, EPPIN and SEMG1. Interacts (immaturely glycosylated pre-secreted form) with HSPA5; this interaction promotes CLU stability and facilitates stress-induced CLU retrotranslocation from the secretory pathway to the mitochondria, thereby reducing stress-induced apoptosis by stabilizing mitochondrial membrane integrity. Interacts with BCL2L1; this interaction releases and activates BAX and promotes cell death. Interacts with TGFBR2 and ACVR1 (By similarity). Interacts (secreted form) with STMN3; this interaction may act as an important modulator during neuronal differentiation (By similarity). Interacts with VLDLR and LRP8 (By similarity).
messages: Belongs to the clusterin family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself (By similarity). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed:11697889). When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity).
messages: Heavily N-glycosylated. About 30% of the protein mass is comprised of complex N-linked carbohydrate. Endoplasmic reticulum (ER) stress induces changes in glycosylation status and increases level of hypoglycosylated forms. Core carbohydrates are essential for chaperone activity. Non-secreted forms are hypoglycosylated or unglycosylated.
messages: Microsome
messages: Mitochondrion
messages: Mitochondrion membrane
messages: Nucleus
messages: Polyubiquitinated, leading to proteasomal degradation. Under cellular stress, the intracellular level of cleaved form is reduced due to proteasomal degradation.
messages: Proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen (By similarity) (PubMed:7744793). Proteolytic cleavage is not necessary for its chaperone activity. All non-secreted forms are not proteolytically cleaved. Chaperone activity of uncleaved forms is dependent on a non-reducing envoronment (By similarity). This proteolytic maturation is disulfide bond formation dependent (PubMed:7744793).
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9615:TTC30A
gene id: 9615:TTC30A
uniprot id: A0A8C0SZC0
uniprot id: A0A8I3PCE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9615:DEFB121
gene id: 9615:DEFB121
uniprot id: A0A8C0TG73
uniprot id: Q30KT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:FAM163A
gene id: 9615:FAM163A
uniprot id: A0A8C0QB04
uniprot id: A0A8I3MXW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9615:FGF4
gene id: 9615:FGF4
uniprot id: A0A8C0QMH2
uniprot id: J9P3I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

9615:GATA1
gene id: 9615:GATA1
uniprot id: A0A8C0S1L4
uniprot id: A0A8I3QVV2
names: Subcellular Location Annotation
messages: Nucleus

9615:C12H6orf89
gene id: 9615:C12H6orf89
uniprot id: A0A8C0T6T3
uniprot id: A0A8I3N4H8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9615:RAB13
gene id: 9615:RAB13
uniprot id: F1PTE3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with BICDL2/BICDR2. Interacts with LEPROT and LEPROTL1.
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab may be activated by DENND1C, a guanine exchange factor. Activated in response to insulin (By similarity).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
messages: lamellipodium
messages: tight junction
messages: trans-Golgi network membrane

9615:GRB2
gene id: 9615:GRB2
uniprot id: A0A8C0M7T4
uniprot id: A0A8I3PT69
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9615:KCNJ13
gene id: 9615:KCNJ13
uniprot id: A0A8C0PEE7
uniprot id: A0A8I3PWN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9615:SPNS3
gene id: 9615:SPNS3
uniprot id: A0A8C0TKI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9615:EGF
gene id: 9615:EGF
uniprot id: Q9BEA0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
messages: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity). Interacts with RHBDF2 (By similarity).
messages: Membrane

9615:MYH16
gene id: 9615:MYH16
uniprot id: A0A8C0S3A0
uniprot id: A0A8I3RT35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9615:ABHD12
gene id: 9615:ABHD12
uniprot id: A0A8C0SI54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:ST18
gene id: 9615:ST18
uniprot id: A0A8C0P371
uniprot id: A0A8P0SC95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9615:MBOAT1
gene id: 9615:MBOAT1
uniprot id: A0A8I3NX08
names: Subcellular Location Annotation
messages: Membrane

9615:PPARA
gene id: 9615:PPARA
uniprot id: Q95N78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 and ASXL2. Interacts with PER2. Interacts with SIRT1; the interaction seems to be modulated by NAD(+) levels (By similarity). Interacts with CRY1 and CRY2 (By similarity).
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).
messages: Nucleus

9615:CLDN20
gene id: 9615:CLDN20
uniprot id: A0A8C0MMR7
uniprot id: A0A8I3MBL3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:PARP16
gene id: 9615:PARP16
uniprot id: A0A8I3PXK7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:CTSW
gene id: 9615:CTSW
uniprot id: A0A8C0SR41
uniprot id: A0A8I3NT28
names: Similarity
messages: Belongs to the peptidase C1 family.

9615:SNRPC
gene id: 9615:SNRPC
uniprot id: E2RGI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA (By similarity). Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites (By similarity).
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus

9615:TMCO5A
gene id: 9615:TMCO5A
uniprot id: A0A8C0RTL7
uniprot id: A0A8I3PM49
names: Subcellular Location Annotation
messages: Membrane

9615:GPD1L
gene id: 9615:GPD1L
uniprot id: A0A8I3PEF9
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9615:MFAP3L
gene id: 9615:MFAP3L
uniprot id: A0A8C0RPK0
uniprot id: A0A8I3Q0L7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:PROP1
gene id: 9615:PROP1
uniprot id: Q9TTD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus
messages: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

9615:SLC25A32
gene id: 9615:SLC25A32
uniprot id: A0A8C0Q9B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:ANAPC10
gene id: 9615:ANAPC10
uniprot id: A0A8C0MQZ1
uniprot id: A0A8I3RWP5
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9615:UNC93A
gene id: 9615:UNC93A
uniprot id: A0A8C0Q485
uniprot id: A0A8I3MYR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9615:RAB3GAP1
gene id: 9615:RAB3GAP1
uniprot id: A0A8C0YWZ8
uniprot id: A0A8I3NA37
uniprot id: A0A8I3RUY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm

9615:MMP13
gene id: 9615:MMP13
uniprot id: A0A8C0Z2W1
uniprot id: A0A8I3MWY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
messages: Secreted

9615:BCKDK
gene id: 9615:BCKDK
uniprot id: A0A8I3NCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9615:KEAP1
gene id: 9615:KEAP1
uniprot id: A0A8C0T754
uniprot id: A0A8I3PZ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

9615:FOXP4
gene id: 9615:FOXP4
uniprot id: A0A8C0MKR4
uniprot id: A0A8I3NLA6
names: Subcellular Location Annotation
messages: Nucleus

9615:MANBA
gene id: 9615:MANBA
uniprot id: A0A8C0TKG1
uniprot id: A0A8I3PSC3
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

9615:GPM6A
gene id: 9615:GPM6A
uniprot id: A0A8C0RHT9
uniprot id: A0A8I3PIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9615:SLC35F2
gene id: 9615:SLC35F2
uniprot id: A0A8C0SGZ9
uniprot id: A0A8P0NGF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9615:BIRC3
gene id: 9615:BIRC3
uniprot id: A1E2V0
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Interacts with PRSS25; the interaction inhibits apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interaction with TRAF2 is required for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B. Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.
messages: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
messages: Nucleus
messages: USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination.

9615:DAPK2
gene id: 9615:DAPK2
uniprot id: A0A8I3PIC8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:ACVR2A
gene id: 9615:ACVR2A
uniprot id: A0A8C0Z3E6
uniprot id: A0A8I3MYH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9615:NR4A2
gene id: 9615:NR4A2
uniprot id: A0A8C0MMA8
uniprot id: A0A8C0YX67
uniprot id: A0A8I3PJX5
uniprot id: A0A8I3PXP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9615:ATP6V0E1
gene id: 9615:ATP6V0E1
uniprot id: Q9BDP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).

9615:DBH
gene id: 9615:DBH
uniprot id: Q68CI2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Conversion of dopamine to noradrenaline.
messages: Homotetramer; composed of two disulfide-linked dimers.
messages: N-glycosylated.
messages: Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.
messages: Secreted
messages: chromaffin granule lumen
messages: chromaffin granule membrane
messages: secretory vesicle lumen
messages: secretory vesicle membrane

9615:NLN
gene id: 9615:NLN
uniprot id: A0A8C0PWY4
uniprot id: A0A8I3NF09
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9615:FMNL1
gene id: 9615:FMNL1
uniprot id: A0A8C0MEG9
uniprot id: A0A8C0YWZ7
uniprot id: A0A8I3MYK6
names: Similarity
messages: Belongs to the formin homology family.

9615:ASPHD1
gene id: 9615:ASPHD1
uniprot id: A0A8I3MHW3
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9615:SLC30A6
gene id: 9615:SLC30A6
uniprot id: A0A8C0SIR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9615:PRUNE1
gene id: 9615:PRUNE1
uniprot id: A0A8C0SEL8
uniprot id: A0A8I3PAC2
uniprot id: A0A8I3PAL6
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9615:TNR
gene id: 9615:TNR
uniprot id: A0A8I3RVA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9615:CCDC39
gene id: 9615:CCDC39
uniprot id: A0A8P0TE27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: cilium axoneme

9615:EBPL
gene id: 9615:EBPL
uniprot id: A0A8I3PRC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:SLC7A9
gene id: 9615:SLC7A9
uniprot id: A0A8C0LTE7
uniprot id: Q0QVT5
names: Subcellular Location Annotation
messages: Membrane

9615:CENPS
gene id: 9615:CENPS
uniprot id: A0A8C0NTG5
uniprot id: A0A8P0NI70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: Nucleus
messages: kinetochore

9615:AGPAT4
gene id: 9615:AGPAT4
uniprot id: A0A8C0RUZ5
uniprot id: A0A8I3MKS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane

9615:HMGCL
gene id: 9615:HMGCL
uniprot id: A0A8C0LXZ1
uniprot id: A0A8I3P3W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9615:LSM8
gene id: 9615:LSM8
uniprot id: A0A8C0QGD7
uniprot id: A0A8P0PM70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9615:GYPA
gene id: 9615:GYPA
uniprot id: P02727
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycophorin-A family.
messages: Glycophorin A is the major intrinsic membrane sialoglycoprotein of the erythrocyte. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane (By similarity).
messages: Homodimer.
messages: Membrane

9615:TSSK6
gene id: 9615:TSSK6
uniprot id: A0A8C0N7A6
uniprot id: A0A8I3S0T7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:RPS3A
gene id: 9615:RPS3A
uniprot id: A0A8I3MUG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9615:TERF2IP
gene id: 9615:TERF2IP
uniprot id: A0A8P0SNQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9615:SH2D1A
gene id: 9615:SH2D1A
uniprot id: A0A8C0N7L7
uniprot id: A0A8I3PXT7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9615:HPF1
gene id: 9615:HPF1
uniprot id: A0A8C0T9D1
uniprot id: A0A8C0TAF1
uniprot id: A0A8I3PVU5
uniprot id: A0A8I3Q3B2
names: Similarity
messages: Belongs to the HPF1 family.

9615:SEC24C
gene id: 9615:SEC24C
uniprot id: A0A8C0MUM5
uniprot id: A0A8I3N796
uniprot id: A0A8I3N9U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9615:ST8SIA1
gene id: 9615:ST8SIA1
uniprot id: A0A8C0TU42
uniprot id: A0A8I3S0P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:FAM20C
gene id: 9615:FAM20C
uniprot id: A0A8C0YRN5
names: Similarity
messages: Belongs to the FAM20 family.

9615:DMD
gene id: 9615:DMD
uniprot id: O97592
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
messages: Interacts with SYNM (By similarity). Interacts with the syntrophins SNTG1 and SNTG2. Interacts with KRT19. Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1 (By similarity). Interacts with SYNM; SNTA1 and SNTB1. Interacts with CMYA5. Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells. Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity). Interacts with DTNB (By similarity). Interacts with PGM5; the interaction is direct (By similarity).
messages: Postsynaptic cell membrane
messages: cytoskeleton
messages: sarcolemma

9615:DLL4
gene id: 9615:DLL4
uniprot id: A0A8C0TZ79
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9615:NIM1K
gene id: 9615:NIM1K
uniprot id: A0A8C0S894
uniprot id: A0A8I3MIY1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:STK4
gene id: 9615:STK4
uniprot id: A0A8C0TTC2
uniprot id: A0A8I3NQ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9615:AADACL3
gene id: 9615:AADACL3
uniprot id: A0A8C0Q290
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9615:VIL1
gene id: 9615:VIL1
uniprot id: A0A8C0PEC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: filopodium tip
messages: lamellipodium
messages: microvillus
messages: ruffle

9615:HMX2
gene id: 9615:HMX2
uniprot id: A0A8C0P0P1
uniprot id: A0A8I3PRN8
names: Subcellular Location Annotation
messages: Nucleus

9615:COL1A2
gene id: 9615:COL1A2
uniprot id: O46392
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the fibrillar collagen family.
messages: Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
messages: Trimers of one alpha 2(I) and two alpha 1(I) chains.
messages: Type I collagen is a member of group I collagen (fibrillar forming collagen).
messages: extracellular matrix

9615:IFNA5
gene id: 9615:IFNA5
uniprot id: Q75UL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9615:IL2RG
gene id: 9615:IL2RG
uniprot id: P40321
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.
messages: Cell membrane
messages: Cell surface
messages: Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).
messages: Defects in IL2RG are the cause of a canine X-linked severe combined immunodeficiency.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation (By similarity).

9615:LBH
gene id: 9615:LBH
uniprot id: A0A8C0NJW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9615:PAX5
gene id: 9615:PAX5
uniprot id: A0A8C0MG08
uniprot id: A0A8I3NE25
uniprot id: A0A8I3P001
names: Subcellular Location Annotation
messages: Nucleus

9615:PHYHIPL
gene id: 9615:PHYHIPL
uniprot id: A0A8C0PKP4
uniprot id: A0A8I3RQF8
names: Similarity
messages: Belongs to the PHYHIP family.

9615:NEDD9
gene id: 9615:NEDD9
uniprot id: A0A8P0NC68
uniprot id: A0A8P0NWP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9615:CNTNAP4
gene id: 9615:CNTNAP4
uniprot id: A0A8C0M4P1
uniprot id: A0A8P0NLB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:FABP6
gene id: 9615:FABP6
uniprot id: A0A8C0N528
uniprot id: A0A8I3RRB0
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9615:CLPP
gene id: 9615:CLPP
uniprot id: A0A8C0NYE4
uniprot id: A0A8I3N7L4
names: Similarity
messages: Belongs to the peptidase S14 family.

9615:KREMEN1
gene id: 9615:KREMEN1
uniprot id: A0A8I3Q3U5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CAPZA3
gene id: 9615:CAPZA3
uniprot id: A0A8C0PE89
uniprot id: A0A8I3PDJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9615:WARS1
gene id: 9615:WARS1
uniprot id: A0A8C0MLF5
uniprot id: A0A8I3MMH0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:PNP
gene id: 9615:PNP
uniprot id: A0A8C0S933
uniprot id: A0A8I3PKI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9615:PPP1R10
gene id: 9615:PPP1R10
uniprot id: A0A8C0SPG3
uniprot id: A0A8I3RV83
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9615:CDCA7L
gene id: 9615:CDCA7L
uniprot id: A0A8C0PN79
uniprot id: A0A8C0Q6I7
uniprot id: A0A8I3NA84
uniprot id: A0A8I3RUD1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:MRPL33
gene id: 9615:MRPL33
uniprot id: A0A8C0NB67
uniprot id: A0A8I3NEN8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9615:UTP23
gene id: 9615:UTP23
uniprot id: A0A8C0M6C2
uniprot id: A0A8I3P233
names: Subcellular Location Annotation
messages: nucleolus

9615:ATP5IF1
gene id: 9615:ATP5IF1
uniprot id: A0A8C0MWR0
uniprot id: A0A8I3NGS0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9615:FUT10
gene id: 9615:FUT10
uniprot id: Q5F2N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation (By similarity). Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity).

9615:UBA6
gene id: 9615:UBA6
uniprot id: A0A8P0P6L4
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9615:TMEM167A
gene id: 9615:TMEM167A
uniprot id: A0A8C0MMF9
uniprot id: A0A8I3PKI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

9615:GALNT17
gene id: 9615:GALNT17
uniprot id: A0A8C0QLX7
uniprot id: A0A8I3MHX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:COG6
gene id: 9615:COG6
uniprot id: A0A8C0P3P2
uniprot id: A0A8C0QCE0
uniprot id: A0A8I3PHX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9615:YES1
gene id: 9615:YES1
uniprot id: A0A8C0PUT1
uniprot id: A0A8I3MFD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:LOC489332
gene id: 9615:LOC489332
uniprot id: A0A8I3RYN7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:LAMTOR2
gene id: 9615:LAMTOR2
uniprot id: A0A8C0TCX0
uniprot id: A0A8I3NEX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9615:RXRB
gene id: 9615:RXRB
uniprot id: A0A8C0T8B7
uniprot id: A0A8P0N438
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9615:ACTL8
gene id: 9615:ACTL8
uniprot id: A0A8C0RVI9
uniprot id: A0A8I3MRJ3
names: Similarity
messages: Belongs to the actin family.

9615:RASGRP2
gene id: 9615:RASGRP2
uniprot id: A0A8I3Q8A5
names: Similarity
messages: Belongs to the RASGRP family.

9615:TMEM199
gene id: 9615:TMEM199
uniprot id: A0A8C0T8L1
uniprot id: A0A8I3MW30
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:PPRC1
gene id: 9615:PPRC1
uniprot id: A0A8C0TJN8
uniprot id: A0A8I3PU28
names: Subcellular Location Annotation
messages: Nucleus

9615:NDUFA2
gene id: 9615:NDUFA2
uniprot id: A0A8C0PZN0
uniprot id: A0A8I3MRD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:NEMP1
gene id: 9615:NEMP1
uniprot id: A0A8C0N2B1
uniprot id: A0A8I3N316
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9615:SLC25A3
gene id: 9615:SLC25A3
uniprot id: A0A8C0P0S3
uniprot id: A0A8C0RPF9
uniprot id: A0A8I3Q027
uniprot id: A0A8I3Q073
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9615:BTG3
gene id: 9615:BTG3
uniprot id: A0A8C0TUY9
uniprot id: A0A8I3PTE5
names: Similarity
messages: Belongs to the BTG family.

9615:ANKRD13D
gene id: 9615:ANKRD13D
uniprot id: A0A8C0SDF0
uniprot id: A0A8I3NCP1
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9615:CLTCL1
gene id: 9615:CLTCL1
uniprot id: A0A8C0SZX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9615:PPM1A
gene id: 9615:PPM1A
uniprot id: A0A8C0Q407
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9615:C6H1orf52
gene id: 9615:C6H1orf52
uniprot id: A0A8C0NII7
uniprot id: A0A8I3RPP3
names: Similarity
messages: Belongs to the UPF0690 family.

9615:CCDC103
gene id: 9615:CCDC103
uniprot id: A0A8C0SL01
uniprot id: A0A8I3MY38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9615:SNURF
gene id: 9615:SNURF
uniprot id: A0A8C0S284
names: Similarity
messages: Belongs to the SNURF family.

9615:SLC46A2
gene id: 9615:SLC46A2
uniprot id: Q866G7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. SLC46A family.
messages: Glycosylated.
messages: Highly expressed by the epididymal duct epithelium.
messages: May act as a transporter (By similarity). May be involved in establishing and maintaining the luminal fluid microenvironment.

9615:CD4
gene id: 9615:CD4
uniprot id: P33705
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in macrophages and a subset of T lymphocytes.
messages: Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs.
messages: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
messages: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
messages: Phosphorylated by PKC; phosphorylation plays an important role for CD4 internalization.
messages: The Ig-like V-type domain mediates the interaction with MHCII.

9615:STK38L
gene id: 9615:STK38L
uniprot id: A0A8C0PMK8
uniprot id: E2R001
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:UHRF2
gene id: 9615:UHRF2
uniprot id: A0A8C0S7W7
uniprot id: A0A8I3PVP0
names: Subcellular Location Annotation
messages: Nucleus

9615:NLRP3
gene id: 9615:NLRP3
uniprot id: A0A8C0M351
uniprot id: A0A8C0SSV5
uniprot id: A0A8C0YZB5
uniprot id: A0A8I3NW69
uniprot id: A0A8I3P020
uniprot id: A0A8I3PDL7
names: Similarity
messages: Belongs to the NLRP family.

9615:GPC3
gene id: 9615:GPC3
uniprot id: A0A8C0TMC5
uniprot id: A0A8I3Q662
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9615:FDPS
gene id: 9615:FDPS
uniprot id: A0A8C0PL88
uniprot id: A0A8I3NF82
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9615:NSUN5
gene id: 9615:NSUN5
uniprot id: A0A8C0MWW7
uniprot id: A0A8I3MRS9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9615:SLC35A3
gene id: 9615:SLC35A3
uniprot id: O77592
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Interacts with SLC35A2; the interaction is reduced in the presence of SLC35A4 (By similarity). Found in a complex with SLC35A2 and SLC35A4 (By similarity).
messages: Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides (By similarity).

9615:GAD2
gene id: 9615:GAD2
uniprot id: Q4PRC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the production of GABA.
messages: Cytoplasmic vesicle
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Palmitoylated; which is required for presynaptic clustering.
messages: Phosphorylated; which does not affect kinetic parameters or subcellular location.
messages: Presynaptic cell membrane
messages: cytosol

9615:HSDL2
gene id: 9615:HSDL2
uniprot id: A0A8C0SST8
uniprot id: A0A8I3MXG8
names: Subcellular Location Annotation
messages: Peroxisome

9615:HIKESHI
gene id: 9615:HIKESHI
uniprot id: A0A8C0TF55
uniprot id: A0A8I3N0H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9615:IBSP
gene id: 9615:IBSP
uniprot id: A0A8C0RTV9
uniprot id: A0A8P0SEN8
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9615:PCOLCE
gene id: 9615:PCOLCE
uniprot id: A0A8C0SJ81
uniprot id: A0A8I3MHG0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:ADRB2
gene id: 9615:ADRB2
uniprot id: P54833
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
messages: Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (By similarity). Interacts with USP20 and USP33 (By similarity). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4 (By similarity). Interacts with MARCHF2 (By similarity).
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
messages: Palmitoylated. Mainly palmitoylated at Cys-341. Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi. Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor. Could be depalmitoylated by LYPLA1 at the plasma membrane.
messages: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity).
messages: Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
messages: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
messages: Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity).

9615:GALNT11
gene id: 9615:GALNT11
uniprot id: A0A8C0P5P5
uniprot id: A0A8I3NK66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:CYP51A1
gene id: 9615:CYP51A1
uniprot id: A0A8P0N517
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:SLC5A8
gene id: 9615:SLC5A8
uniprot id: A0A8C0YW03
uniprot id: A0A8I3N523
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9615:LOC479708
gene id: 9615:LOC479708
uniprot id: A0A8C0Q8T5
uniprot id: A0A8I3MMI6
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

9615:LOC100684058
gene id: 9615:LOC100684058
uniprot id: A0A8C0SUQ2
uniprot id: A0A8I3P164
names: Similarity
messages: Belongs to the peptidase M67C family.

9615:PTER
gene id: 9615:PTER
uniprot id: A0A8C0Q3W7
uniprot id: A0A8I3P1X1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SI
gene id: 9615:SI
uniprot id: A0A8C0N6P2
uniprot id: A0A8P0NGA4
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:GNG3
gene id: 9615:GNG3
uniprot id: A0A8C0RDX7
uniprot id: A0A8I3MYE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:HSPA4
gene id: 9615:HSPA4
uniprot id: Q2TFN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9615:KRT33A
gene id: 9615:KRT33A
uniprot id: A0A8C0NL65
uniprot id: A0A8P0NHD9
names: Similarity
messages: Belongs to the intermediate filament family.

9615:NAGA
gene id: 9615:NAGA
uniprot id: A0A8C0PJN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9615:LOC479668
gene id: 9615:LOC479668
uniprot id: A0A8C0T540
uniprot id: A0A8I3N4M8
names: Caution
names: Function
names: Similarity
messages: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:DLX2
gene id: 9615:DLX2
uniprot id: A0A8P0NLZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9615:PAQR5
gene id: 9615:PAQR5
uniprot id: A0A8C0MV23
uniprot id: A0A8C0SA82
uniprot id: A0A8I3PB51
uniprot id: A0A8I3PL13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:CGA
gene id: 9615:CGA
uniprot id: A0A0F7RPW1
uniprot id: Q9XSW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9615:SYN1
gene id: 9615:SYN1
uniprot id: A0A8I3QAQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synapsin family.
messages: Golgi apparatus
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: synaptic vesicle

9615:GPX5
gene id: 9615:GPX5
uniprot id: O46607
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glutathione peroxidase family.
messages: Epididymis.
messages: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
messages: Secreted

9615:MMP12
gene id: 9615:MMP12
uniprot id: A0A8C0Z2Z1
uniprot id: A0A8I3MBX9
names: Similarity
messages: Belongs to the peptidase M10A family.

9615:SLC7A10
gene id: 9615:SLC7A10
uniprot id: A0A8C0LTZ3
uniprot id: A0A8I3MAA4
names: Subcellular Location Annotation
messages: Membrane

9615:PPP1R2C
gene id: 9615:PPP1R2C
uniprot id: A0A8C0SKI3
uniprot id: A0A8I3Q1F6
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9615:LOC483462
gene id: 9615:LOC483462
uniprot id: A0A8C0RMK9
uniprot id: A0A8I3PCA4
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9615:MC4R
gene id: 9615:MC4R
uniprot id: A0A8C0Q121
uniprot id: Q4JIV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9615:NTMT1
gene id: 9615:NTMT1
uniprot id: A0A8C0YS23
uniprot id: A0A8I3PWP8
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9615:IRF5
gene id: 9615:IRF5
uniprot id: A0A8C0S8H2
uniprot id: A0A8I3PFI4
uniprot id: A0A8I3PFT0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:VPS36
gene id: 9615:VPS36
uniprot id: A0A8C0NVX9
uniprot id: A0A8C0RNS8
uniprot id: A0A8P0SBE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9615:FAM187B
gene id: 9615:FAM187B
uniprot id: A0A8I3N5J1
names: Subcellular Location Annotation
messages: Membrane

9615:E2F6
gene id: 9615:E2F6
uniprot id: A0A8C0QL87
uniprot id: A0A8I3QHA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9615:MRPL22
gene id: 9615:MRPL22
uniprot id: A0A8C0RGD7
uniprot id: A0A8I3MQF3
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9615:KRT15
gene id: 9615:KRT15
uniprot id: A0A8C0S9K8
names: Similarity
messages: Belongs to the intermediate filament family.

9615:DSCC1
gene id: 9615:DSCC1
uniprot id: A0A8C0S8Q1
uniprot id: A0A8I3MVX5
names: Similarity
messages: Belongs to the DCC1 family.

9615:NMB
gene id: 9615:NMB
uniprot id: A0A8C0RWX7
uniprot id: A0A8I3MML2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9615:CDK10
gene id: 9615:CDK10
uniprot id: A0A8C0N0J1
uniprot id: A0A8C0PD07
uniprot id: A0A8I3MEU6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:KCNJ12
gene id: 9615:KCNJ12
uniprot id: A0A8C0MAF6
uniprot id: F6KIF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

9615:GLCE
gene id: 9615:GLCE
uniprot id: A0A8I3PE77
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9615:MFAP3
gene id: 9615:MFAP3
uniprot id: A0A8C0Q959
uniprot id: A0A8I3MU20
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:MZT2B
gene id: 9615:MZT2B
uniprot id: A0A8C0RSE1
uniprot id: A0A8I3PUW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9615:ENTPD3
gene id: 9615:ENTPD3
uniprot id: A0A8C0RIZ1
uniprot id: A0A8I3P1J9
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:RPL23
gene id: 9615:RPL23
uniprot id: A0A8C0Q8J2
uniprot id: A0A8I3NHL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9615:CDKAL1
gene id: 9615:CDKAL1
uniprot id: A0A8C0NRW3
uniprot id: J7MDG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9615:TMEM50A
gene id: 9615:TMEM50A
uniprot id: A0A8C0LR67
uniprot id: A0A8I3P1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9615:TNFSF13
gene id: 9615:TNFSF13
uniprot id: A0A8C0Q4U9
uniprot id: B5B3U5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:FGB
gene id: 9615:FGB
uniprot id: A0A8C0SGZ1
uniprot id: A0A8I3NBD6
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9615:CFAP298
gene id: 9615:CFAP298
uniprot id: A0A8C0N055
uniprot id: A0A8I3PIL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9615:HPDL
gene id: 9615:HPDL
uniprot id: A0A8C0T247
uniprot id: A0A8I3PQJ0
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9615:STEAP1
gene id: 9615:STEAP1
uniprot id: A0A8C0YZN0
uniprot id: A0A8I3N6Y2
names: Subcellular Location Annotation
messages: Membrane

9615:IRX5
gene id: 9615:IRX5
uniprot id: A0A8I3MH94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9615:BCL2L2
gene id: 9615:BCL2L2
uniprot id: Q45T69
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Bcl-2 family.
messages: Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
messages: Mitochondrion membrane
messages: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX (By similarity).
messages: The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2 (By similarity).
messages: The BH4 motif seems to be involved in the anti-apoptotic function.

9615:DCP2
gene id: 9615:DCP2
uniprot id: A0A8C0SFH1
uniprot id: A0A8I3MY06
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9615:LOC100856765
gene id: 9615:LOC100856765
uniprot id: A0A8I3SA72
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9615:AP1M1
gene id: 9615:AP1M1
uniprot id: A0A8C0T4S7
uniprot id: A0A8I3Q641
uniprot id: A0A8I3QA46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9615:BHMT
gene id: 9615:BHMT
uniprot id: A0A8C0NUX3
uniprot id: A0A8C0QDD7
uniprot id: A0A8I3MUM0
uniprot id: A0A8I3RTW5
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9615:PIR
gene id: 9615:PIR
uniprot id: A0A8C0YXE9
uniprot id: A0A8I3QK41
names: Similarity
messages: Belongs to the pirin family.

9615:FOXP1
gene id: 9615:FOXP1
uniprot id: A0A8C0MJ47
uniprot id: A0A8C0MPU9
uniprot id: A0A8I3NBG2
uniprot id: A0A8I3NN58
names: Subcellular Location Annotation
messages: Nucleus

9615:TECR
gene id: 9615:TECR
uniprot id: A0A8P0SZF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:SH3BGRL
gene id: 9615:SH3BGRL
uniprot id: A0A8C0T5H5
uniprot id: A0A8I3PBA6
names: Similarity
messages: Belongs to the SH3BGR family.

9615:BABAM2
gene id: 9615:BABAM2
uniprot id: A0A8C0SHX9
uniprot id: A0A8I3N946
uniprot id: A0A8I3NA35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9615:MMP26
gene id: 9615:MMP26
uniprot id: A0A8C0P0M1
uniprot id: A0A8I3PG50
names: Similarity
messages: Belongs to the peptidase M10A family.

9615:HACD1
gene id: 9615:HACD1
uniprot id: Q4W1W1
names: Caution
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Defects in HACD1 may be the cause of autosomal recessive centronuclear myopathy in Labradors.
messages: Endoplasmic reticulum membrane
messages: May interact with enzymes of the ELO family (including ELOVL1); with those enzymes that mediate condensation, the first of the four steps of the reaction cycle responsible for fatty acids elongation, may be part of a larger fatty acids elongase complex.
messages: Shares some similarity with tyrosine phosphatase proteins but it has no phosphatase activity.
messages: Skeletal muscle.

9615:HAX1
gene id: 9615:HAX1
uniprot id: A0A8P0SLG6
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

9615:SLC13A3
gene id: 9615:SLC13A3
uniprot id: A0A8I3P9M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9615:OSBPL6
gene id: 9615:OSBPL6
uniprot id: A0A8C0PAZ5
uniprot id: A0A8C0PEE8
uniprot id: A0A8C0T0U6
uniprot id: A0A8C0T2I7
uniprot id: A0A8C0T5E1
uniprot id: A0A8I3PNT4
names: Similarity
messages: Belongs to the OSBP family.

9615:HOMEZ
gene id: 9615:HOMEZ
uniprot id: A0A8C0PX36
uniprot id: A0A8I3RSR5
uniprot id: A0A8P0SSZ6
names: Subcellular Location Annotation
messages: Nucleus

9615:CTSV
gene id: 9615:CTSV
uniprot id: Q9GL24
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Dimer of a heavy and a light chain linked by disulfide bonds. Interacts with Long isoform of CD74/Ii chain; the interaction stabilizes the conformation of mature CTSL.
messages: During export along the endocytic pathway, pro-CTSL undergoes several proteolytic cleavages to generate the CTSL single-chain and two-chain mature forms, composed of a heavy chain linked to a light chain by disulfide bonds (By similarity). Autocleavage; produces the single-chain CTSL after cleavage of the propeptide. The cleavage can be intermolecular (By similarity).
messages: Inhibited by the propeptide produced by autocleavage (By similarity). Long isoform of CD74/Ii chain stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of APCs. IFNG enhances the conversion into the CTSL mature and active form (By similarity). Inhibited by CST6. Inhibited by the glycopeptide antibiotic teicoplanin. Inhibited by amantadine (By similarity).
messages: Lysosome
messages: Secreted
messages: Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity).
messages: chromaffin granule
messages: extracellular space

9615:TMEM9B
gene id: 9615:TMEM9B
uniprot id: A0A8C0S073
uniprot id: A0A8I3NHE6
names: Similarity
messages: Belongs to the TMEM9 family.

9615:LOC488190
gene id: 9615:LOC488190
uniprot id: A0A8C0MNJ5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:LHX4
gene id: 9615:LHX4
uniprot id: A0A8C0RBX9
uniprot id: A0A8I3MPI3
names: Subcellular Location Annotation
messages: Nucleus

9615:TGFB2
gene id: 9615:TGFB2
uniprot id: A0A8C0P803
uniprot id: A0A8C0RRP5
uniprot id: A0A8I3PZZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9615:GATB
gene id: 9615:GATB
uniprot id: A0A8C0S656
uniprot id: A0A8I3N3T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9615:ORC5
gene id: 9615:ORC5
uniprot id: A0A8C0SJK7
uniprot id: A0A8I3P3M2
names: Subcellular Location Annotation
messages: Nucleus

9615:GSKIP
gene id: 9615:GSKIP
uniprot id: A0A8C0PX38
uniprot id: A0A8I3MKY8
names: Similarity
messages: Belongs to the GSKIP family.

9615:KATNB1
gene id: 9615:KATNB1
uniprot id: A0A8C0M431
uniprot id: A0A8I3N368
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9615:EIF4A1
gene id: 9615:EIF4A1
uniprot id: A0A8C0NHT7
uniprot id: A0A8I3S757
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

9615:MORF4L2
gene id: 9615:MORF4L2
uniprot id: A0A8C0N2B4
uniprot id: A0A8I3PF91
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
messages: Nucleus

9615:LOC609748
gene id: 9615:LOC609748
uniprot id: A0A8C0TCW0
uniprot id: A0A8I3PNX9
names: Similarity
messages: Belongs to the GroES chaperonin family.

9615:TCTA
gene id: 9615:TCTA
uniprot id: A0A8C0T5M5
uniprot id: A0A8I3PQW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9615:ABCC6
gene id: 9615:ABCC6
uniprot id: A0A8C0PRX0
uniprot id: A0A8P0SM65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9615:GALNT10
gene id: 9615:GALNT10
uniprot id: A0A8C0QF66
uniprot id: A0A8I3MW00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:LOC102153873
gene id: 9615:LOC102153873
uniprot id: A0A8C0SPB5
uniprot id: A0A8I3QMQ6
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9615:PRMT7
gene id: 9615:PRMT7
uniprot id: A0A8C0SAK1
uniprot id: A0A8C0SCK0
uniprot id: A0A8I3NII7
uniprot id: A0A8I3NU79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

9615:RPA1
gene id: 9615:RPA1
uniprot id: A0A8C0Q875
uniprot id: A0A8I3NNF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

9615:SCNN1B
gene id: 9615:SCNN1B
uniprot id: Q95165
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by WNK1, WNK2, WNK3 and WNK4.
messages: Apical cell membrane
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
messages: Cytoplasmic vesicle membrane
messages: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties. Interacts with NEDD4 (via WW domains). Interacts with NEDD4L (via WW domains). Interacts with WWP1 (via WW domains). Interacts with WWP2 (via WW domains). Interacts with the full-length immature form of PCSK9 (pro-PCSK9). Interacts (N-glycosylated) with BPIFA1; the interaction is direct and inhibits the proteolytic processing of SCNN1A and SCNN1G and the activation of ENaC.
messages: N-glycosylated. N-glycosylation is required for interaction with BPIFA1.
messages: Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

9615:COQ10B
gene id: 9615:COQ10B
uniprot id: A0A8C0MXW0
uniprot id: A0A8I3Q9W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9615:CNTNAP5
gene id: 9615:CNTNAP5
uniprot id: Q0V8T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.
messages: Membrane

9615:S1PR4
gene id: 9615:S1PR4
uniprot id: A0A8C0REW1
uniprot id: A0A8I3NR19
names: Subcellular Location Annotation
messages: Membrane

9615:PHTF1
gene id: 9615:PHTF1
uniprot id: A0A8C0QB33
uniprot id: A0A8C0QH90
uniprot id: A0A8I3PAC6
uniprot id: A0A8I3PG78
names: Subcellular Location Annotation
messages: Membrane

9615:CRP
gene id: 9615:CRP
uniprot id: T2KEN6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9615:ATP2A1
gene id: 9615:ATP2A1
uniprot id: A0A8C0PSX5
uniprot id: A0A8C0PT52
uniprot id: A0A8I3MN74
uniprot id: A0A8I3MNT3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9615:PTGDR2
gene id: 9615:PTGDR2
uniprot id: A0A8C0QB37
uniprot id: Q2A652
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:GPRC5C
gene id: 9615:GPRC5C
uniprot id: A0A8C0M621
uniprot id: A0A8I3S0J1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:PRKRIP1
gene id: 9615:PRKRIP1
uniprot id: A0A8P0SQZ3
names: Similarity
messages: Belongs to the PRKRIP1 family.

9615:B3GALT1
gene id: 9615:B3GALT1
uniprot id: A0A8C0TY66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:IL33
gene id: 9615:IL33
uniprot id: O97863
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity).
messages: Cytoplasm
messages: Expressed in cultured umbilical artery smooth muscle cells after stimulation with IL1A and IL1B, and to a lesser extent with IFNG. Expressed in vasospastic cerebral arteries after subarachnoid hemorrhage.
messages: Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
messages: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity).
messages: Nucleus
messages: Secreted
messages: The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full-length protein. May also be proteolytically processed by calpains. Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation. In vitro proteolytic cleavage by CASP1 was reported but could not be confirmed in vivo suggesting that IL33 is probably not a direct substrate for that caspase (By similarity).
messages: The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association.
messages: secretory vesicle

9615:POLR1A
gene id: 9615:POLR1A
uniprot id: A0A8C0Z124
uniprot id: A0A8I3NGT8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9615:INTU
gene id: 9615:INTU
uniprot id: A0A8C0MMI7
uniprot id: A0A8I3P133
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

9615:UBP1
gene id: 9615:UBP1
uniprot id: A0A8C0PRR2
uniprot id: A0A8C0S644
uniprot id: A0A8P0SZ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9615:LOC116183080
gene id: 9615:LOC116183080
uniprot id: A0A8C0N1K1
uniprot id: E2R5J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9615:ASF1B
gene id: 9615:ASF1B
uniprot id: A0A8C0T344
uniprot id: A0A8I3S4S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9615:DPYSL5
gene id: 9615:DPYSL5
uniprot id: A0A8C0QDP3
uniprot id: A0A8I3SC06
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9615:SMARCD2
gene id: 9615:SMARCD2
uniprot id: A0A8C0SXK6
uniprot id: A0A8C0T104
uniprot id: A0A8P0P5H7
uniprot id: A0A8P0SHK6
names: Similarity
messages: Belongs to the SMARCD family.

9615:CTNNBL1
gene id: 9615:CTNNBL1
uniprot id: A0A8I3PZ00
names: Subcellular Location Annotation
messages: Nucleus

9615:LOC100687285
gene id: 9615:LOC100687285
uniprot id: A0A8C0S4Y9
uniprot id: J9NZS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9615:PIWIL4
gene id: 9615:PIWIL4
uniprot id: A0A8P0S9T3
names: Similarity
messages: Belongs to the argonaute family.

9615:CLVS1
gene id: 9615:CLVS1
uniprot id: A0A8C0NNW9
uniprot id: A0A8I3Q670
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9615:CYRIB
gene id: 9615:CYRIB
uniprot id: A0A8C0Z0T8
uniprot id: A0A8I3NN08
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9615:SCAMPER
gene id: 9615:SCAMPER
uniprot id: Q9GLJ9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: According to PubMed:11829755, the data associated with PubMed:8700873 are to be considered with caution due to a frameshift in the cDNA used for the experiments.
messages: According to PubMed:12421694, orthologs exist in human (AC Q8IWQ8) and rat (AC Q8CGM6). However, the submitted sequences do not match human and rat reference genome assemblies, suggesting that they are artifactual and that SCAMPER most probably does not exist in human and rat.
messages: Homodimer.
messages: Putative sphingolipid-gated calcium channel.
messages: Sarcoplasmic reticulum
messages: Sarcoplasmic reticulum membrane

9615:ACAT1
gene id: 9615:ACAT1
uniprot id: A0A8C0YWR8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9615:YARS1
gene id: 9615:YARS1
uniprot id: A0A8C0NIQ1
uniprot id: A0A8C0TAE6
uniprot id: A0A8I3MXN7
uniprot id: A0A8P0PLL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

9615:FAM83B
gene id: 9615:FAM83B
uniprot id: A0A8C0NCG0
uniprot id: A0A8I3NIF4
names: Similarity
messages: Belongs to the FAM83 family.

9615:CAB39L
gene id: 9615:CAB39L
uniprot id: A0A8C0NVB7
uniprot id: A0A8I3PQG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9615:RBM42
gene id: 9615:RBM42
uniprot id: A0A8C0MH84
uniprot id: A0A8I3MK86
names: Similarity
messages: Belongs to the RRM RBM42 family.

9615:ICOS
gene id: 9615:ICOS
uniprot id: Q7YR73
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
messages: Homodimer; disulfide-linked.
messages: Membrane
messages: N-glycosylated.

9615:GABBR2
gene id: 9615:GABBR2
uniprot id: A0A8C0MC19
uniprot id: A0A8I3MTR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9615:NOS1
gene id: 9615:NOS1
uniprot id: A0A8C0PPA5
uniprot id: A0A8I3PUD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.
messages: dendritic spine
messages: sarcolemma

9615:SCARB2
gene id: 9615:SCARB2
uniprot id: A0A8C0TQJ6
uniprot id: A0A8I3Q374
names: Similarity
messages: Belongs to the CD36 family.

9615:TMEM38A
gene id: 9615:TMEM38A
uniprot id: A0A8P0SU84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9615:ISCU
gene id: 9615:ISCU
uniprot id: A0A8C0PS73
uniprot id: A0A8I3PX30
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

9615:IK
gene id: 9615:IK
uniprot id: A0A8C0MFM1
uniprot id: A0A8I3RRW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9615:SLC6A9
gene id: 9615:SLC6A9
uniprot id: A0A8C0Q3L9
uniprot id: A0A8C0Q5C1
uniprot id: A0A8I3Q117
uniprot id: A0A8I3Q2P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9615:TNFRSF19
gene id: 9615:TNFRSF19
uniprot id: A0A8C0N1R3
uniprot id: A0A8P0PQV7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MTIF3
gene id: 9615:MTIF3
uniprot id: A0A8I3PVH2
names: Similarity
messages: Belongs to the IF-3 family.

9615:GRHL3
gene id: 9615:GRHL3
uniprot id: A0A8C0LYC3
uniprot id: A0A8C0M313
uniprot id: A0A8I3NTM1
names: Subcellular Location Annotation
messages: Nucleus

9615:PSD3
gene id: 9615:PSD3
uniprot id: A0A8P0P4X3
names: Subcellular Location Annotation
messages: ruffle membrane

9615:DNAH7
gene id: 9615:DNAH7
uniprot id: A0A8I3PLA2
names: Similarity
messages: Belongs to the dynein heavy chain family.

9615:NME2
gene id: 9615:NME2
uniprot id: Q50KA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6) (By similarity). Interacts with CAPN8 (By similarity). Interacts with AKAP13 (By similarity). Interacts ITGB1BP1 (via C-terminal domain region) (By similarity). Interacts with BCL2L10 (By similarity).
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity (By similarity).
messages: Nucleus
messages: Ubiquitous.
messages: lamellipodium
messages: ruffle

9615:HSPB1
gene id: 9615:HSPB1
uniprot id: A0A8C0MMM4
uniprot id: F1PYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9615:ANKRD34B
gene id: 9615:ANKRD34B
uniprot id: A0A8C0Q059
uniprot id: A0A8I3MV87
names: Similarity
messages: Belongs to the ANKRD34 family.

9615:ACTRT2
gene id: 9615:ACTRT2
uniprot id: A0A8P0NKX1
names: Similarity
messages: Belongs to the actin family.

9615:TBX19
gene id: 9615:TBX19
uniprot id: Q5XNS0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters (By similarity).

9615:OR6D7
gene id: 9615:OR6D7
uniprot id: A0A8C0NT13
uniprot id: A0A8I3PYL9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:XPO1
gene id: 9615:XPO1
uniprot id: A0A8C0NXT9
uniprot id: A0A8I3NNH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9615:FH
gene id: 9615:FH
uniprot id: A0A8C0NZZ1
uniprot id: A0A8I3MXC4
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9615:DEF8
gene id: 9615:DEF8
uniprot id: A0A8C0MUU1
names: Similarity
messages: Belongs to the DEF8 family.

9615:RNFT1
gene id: 9615:RNFT1
uniprot id: A0A8C0PJJ5
uniprot id: A0A8I3PSS3
names: Subcellular Location Annotation
messages: Membrane

9615:ITIH2
gene id: 9615:ITIH2
uniprot id: A0A8C0LRI0
uniprot id: A0A8P0SAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9615:RNF10
gene id: 9615:RNF10
uniprot id: A0A8C0TAY8
uniprot id: A0A8I3Q1R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

9615:CENPC
gene id: 9615:CENPC
uniprot id: A0A8P0N5R5
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

9615:SLC35F4
gene id: 9615:SLC35F4
uniprot id: A0A8P0T1W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9615:SNX33
gene id: 9615:SNX33
uniprot id: A0A8I3PEE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9615:NPC1
gene id: 9615:NPC1
uniprot id: Q9GK52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9615:G6PC2
gene id: 9615:G6PC2
uniprot id: A0A8C0P8I7
uniprot id: A0A8I3PK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9615:SULF2
gene id: 9615:SULF2
uniprot id: A0A8C0S0M9
uniprot id: Q32KH1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:OR6C69
gene id: 9615:OR6C69
uniprot id: A0A8C0RNK9
uniprot id: A0A8I3SCI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CEP57L1
gene id: 9615:CEP57L1
uniprot id: A0A8P0TMP2
names: Similarity
messages: Belongs to the translokin family.

9615:TSPYL4
gene id: 9615:TSPYL4
uniprot id: A0A8C0MBM6
uniprot id: A0A8P0TU80
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:LOC482182
gene id: 9615:LOC482182
uniprot id: A0A8C0PPL8
uniprot id: A0A8I3NE83
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:CPXM1
gene id: 9615:CPXM1
uniprot id: A0A8C0T209
uniprot id: A0A8I3NVC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9615:COQ5
gene id: 9615:COQ5
uniprot id: A0A8C0P8S8
uniprot id: A0A8I3Q1K8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9615:KIF3C
gene id: 9615:KIF3C
uniprot id: A0A8C0M8A8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:FAM72A
gene id: 9615:FAM72A
uniprot id: A0A8C0T7S9
uniprot id: A0A8I3PWG4
names: Similarity
messages: Belongs to the FAM72 family.

9615:NEIL3
gene id: 9615:NEIL3
uniprot id: A0A8I3S0H3
names: Similarity
messages: Belongs to the FPG family.

9615:MIDN
gene id: 9615:MIDN
uniprot id: A0A8C0NRB1
uniprot id: A0A8I3NK90
names: Subcellular Location Annotation
messages: Nucleus

9615:MEOX1
gene id: 9615:MEOX1
uniprot id: A0A8C0T3I9
uniprot id: A0A8I3RY40
names: Subcellular Location Annotation
messages: Nucleus

9615:PRKAG1
gene id: 9615:PRKAG1
uniprot id: A0A8C0TRC4
names: Similarity
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.

9615:CDH3
gene id: 9615:CDH3
uniprot id: A0A8C0S9J3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9615:GFM2
gene id: 9615:GFM2
uniprot id: A0A8C0QBW2
uniprot id: A0A8I3MNR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9615:IFRD2
gene id: 9615:IFRD2
uniprot id: A0A8C0SRV3
uniprot id: A0A8I3PB80
names: Similarity
messages: Belongs to the IFRD family.

9615:BSX
gene id: 9615:BSX
uniprot id: A0A8C0LZU5
uniprot id: A0A8I3NND9
names: Subcellular Location Annotation
messages: Nucleus

9615:ATP5F1B
gene id: 9615:ATP5F1B
uniprot id: A0A1B1X468
uniprot id: A0A8C0N0W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9615:CLCN3
gene id: 9615:CLCN3
uniprot id: A0A8C0NYF0
uniprot id: A0A8C0RPW3
uniprot id: Q4LAL7
uniprot id: Q4LAL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9615:ITGB3
gene id: 9615:ITGB3
uniprot id: Q9TUN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9615:MTAP
gene id: 9615:MTAP
uniprot id: A0A8C0MV73
uniprot id: A0A8I3NWM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9615:MT4
gene id: 9615:MT4
uniprot id: Q9TUI5
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia (By similarity).

9615:ELF1
gene id: 9615:ELF1
uniprot id: A0A8C0NJW4
uniprot id: A0A8I3NQS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:SMG9
gene id: 9615:SMG9
uniprot id: A0A8C0LYE7
uniprot id: A0A8C0LYF6
uniprot id: A0A8I3MXZ9
uniprot id: A0A8I3N3N0
names: Similarity
messages: Belongs to the SMG9 family.

9615:ELOVL4
gene id: 9615:ELOVL4
uniprot id: A0A8C0Q9N0
uniprot id: A0A8I3NBA5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9615:KIF18B
gene id: 9615:KIF18B
uniprot id: A0A8I3RTA0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:GJB6
gene id: 9615:GJB6
uniprot id: A0A654ICT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:ALDH3A1
gene id: 9615:ALDH3A1
uniprot id: A3RF36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
messages: Belongs to the aldehyde dehydrogenase family.
messages: Cytoplasm
messages: Homodimer.

9615:SSTR2
gene id: 9615:SSTR2
uniprot id: Q49LX6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain) (By similarity).
messages: Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization (By similarity).

9615:SLC5A2
gene id: 9615:SLC5A2
uniprot id: A0A8C0YT22
uniprot id: A0A8I3NI32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9615:SEC23B
gene id: 9615:SEC23B
uniprot id: A0A8C0TPB4
uniprot id: A0A8C0TQ14
uniprot id: A0A8I3Q0G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9615:RNF182
gene id: 9615:RNF182
uniprot id: A0A8I3PH39
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9615:LAP3
gene id: 9615:LAP3
uniprot id: A0A8C0M6L4
uniprot id: A0A8I3MBN3
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9615:STEAP4
gene id: 9615:STEAP4
uniprot id: A0A8C0SU30
uniprot id: A0A8I3NIZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9615:CYP4A11
gene id: 9615:CYP4A11
uniprot id: Q2VHZ7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:HOXC13
gene id: 9615:HOXC13
uniprot id: A0A8I3NWE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9615:GLMP
gene id: 9615:GLMP
uniprot id: A0A8C0TAQ6
uniprot id: A0A8I3NC89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9615:SEMA6C
gene id: 9615:SEMA6C
uniprot id: A0A8C0SFU0
uniprot id: A0A8I3S2K2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:BMP15
gene id: 9615:BMP15
uniprot id: A0A8C0N9Z8
uniprot id: A0A8I3PTJ6
names: Similarity
messages: Belongs to the TGF-beta family.

9615:SLC7A4
gene id: 9615:SLC7A4
uniprot id: A0A8C0PB92
names: Subcellular Location Annotation
messages: Membrane

9615:ADAMTS9
gene id: 9615:ADAMTS9
uniprot id: A0A8C0N2W2
uniprot id: A0A8C0RIW9
uniprot id: A0A8I3NK12
uniprot id: A0A8I3NP62
uniprot id: A0A8I3NZ51
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:RPS29
gene id: 9615:RPS29
uniprot id: A0A8C0LXK4
uniprot id: A0A8I3RQJ0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9615:TOE1
gene id: 9615:TOE1
uniprot id: A0A8C0NZ09
uniprot id: A0A8I3PDS8
names: Similarity
messages: Belongs to the CAF1 family.

9615:MRE11
gene id: 9615:MRE11
uniprot id: A0A8C0SYU1
uniprot id: A0A8P0S9S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9615:PRDM1
gene id: 9615:PRDM1
uniprot id: A0A8P0NZY7
uniprot id: A0A8P0S9C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9615:CD3D
gene id: 9615:CD3D
uniprot id: A0A8C0PNZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:TLR10
gene id: 9615:TLR10
uniprot id: A0A8C0PJX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9615:SH3BP4
gene id: 9615:SH3BP4
uniprot id: A0A8P0SGV0
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9615:DPYSL2
gene id: 9615:DPYSL2
uniprot id: A0A8C0P7H6
uniprot id: A0A8C0Z1X3
uniprot id: A0A8I3NP20
uniprot id: A0A8I3NRS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

9615:UPF1
gene id: 9615:UPF1
uniprot id: A0A8C0RKR0
uniprot id: A0A8P0SJ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

9615:NLGN4X
gene id: 9615:NLGN4X
uniprot id: A0A8P0SG45
uniprot id: A0A8P0TER7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9615:TMEM87A
gene id: 9615:TMEM87A
uniprot id: A0A8C0P778
uniprot id: A0A8I3P6U1
names: Subcellular Location Annotation
messages: Membrane

9615:CMTM6
gene id: 9615:CMTM6
uniprot id: A0A8C0T010
uniprot id: F1PQS8
names: Subcellular Location Annotation
messages: Membrane

9615:MRPS7
gene id: 9615:MRPS7
uniprot id: A0A8C0M861
uniprot id: A0A8I3Q0A8
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9615:OLFML2A
gene id: 9615:OLFML2A
uniprot id: A0A8C0TH30
uniprot id: A0A8I3N9Z5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CDKN2AIP
gene id: 9615:CDKN2AIP
uniprot id: A0A8C0SPQ4
uniprot id: A0A8P0NAD7
names: Similarity
messages: Belongs to the CARF family.

9615:GPR4
gene id: 9615:GPR4
uniprot id: A0A8C0S0P7
uniprot id: A0A8I3MW45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:LOC485255
gene id: 9615:LOC485255
uniprot id: A0A1K0FUE8
names: Similarity
messages: Belongs to the globin family.

9615:NOC4L
gene id: 9615:NOC4L
uniprot id: A0A8C0P9T7
uniprot id: A0A8P0T7M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane

9615:PGM3
gene id: 9615:PGM3
uniprot id: A0A8I3NIM7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

9615:PIK3IP1
gene id: 9615:PIK3IP1
uniprot id: A0A8I3PG51
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:NOX3
gene id: 9615:NOX3
uniprot id: A7E3L1
names: Subcellular Location Annotation
messages: Membrane

9615:LOC607817
gene id: 9615:LOC607817
uniprot id: A0A8C0RGA2
uniprot id: A0A8I3Q4W8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:ZNF280C
gene id: 9615:ZNF280C
uniprot id: A0A8C0TD36
uniprot id: A0A8I3Q8G8
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9615:PRL
gene id: 9615:PRL
uniprot id: A0A8C0TL28
uniprot id: E2RAF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9615:RTCB
gene id: 9615:RTCB
uniprot id: A0A8C0RZD5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9615:TET2
gene id: 9615:TET2
uniprot id: A0A8P0NCQ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9615:THBS3
gene id: 9615:THBS3
uniprot id: A0A8C0PG23
uniprot id: A0A8I3NMW4
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SENP6
gene id: 9615:SENP6
uniprot id: A0A8C0MMG0
uniprot id: A0A8C0TBK0
uniprot id: A0A8C0TEP7
uniprot id: A0A8C0TFJ1
uniprot id: A0A8P0N5Q8
uniprot id: A0A8P0PBU7
names: Similarity
messages: Belongs to the peptidase C48 family.

9615:DOCK5
gene id: 9615:DOCK5
uniprot id: A0A8C0Z341
names: Similarity
messages: Belongs to the DOCK family.

9615:IL1RN
gene id: 9615:IL1RN
uniprot id: Q9BEH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9615:NDC80
gene id: 9615:NDC80
uniprot id: A0A8C0ND51
uniprot id: A0A8I3ML90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9615:LPCAT1
gene id: 9615:LPCAT1
uniprot id: A0A8C0TQH8
uniprot id: A0A8C0TQJ0
uniprot id: A0A8P0SFP1
uniprot id: A0A8P0TL37
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9615:GPR55
gene id: 9615:GPR55
uniprot id: A0A8P0PK19
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:NFIA
gene id: 9615:NFIA
uniprot id: A0A8P0T5S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9615:ENPP1
gene id: 9615:ENPP1
uniprot id: A0A8C0PJE1
uniprot id: A0A8I3RQK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9615:YOD1
gene id: 9615:YOD1
uniprot id: A0A8C0RQA9
uniprot id: A0A8I3ME45
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9615:PPL
gene id: 9615:PPL
uniprot id: A0A8C0SBJ6
uniprot id: A0A8P0NNT9
names: Subcellular Location Annotation
messages: cytoskeleton

9615:DLA-DOA
gene id: 9615:DLA-DOA
uniprot id: A0A8C0RK32
uniprot id: Q5TJG5
names: Similarity
messages: Belongs to the MHC class II family.

9615:SF3B5
gene id: 9615:SF3B5
uniprot id: A0A8C0NX02
uniprot id: A0A8I3NPU3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9615:SIKE1
gene id: 9615:SIKE1
uniprot id: A0A8C0S5Y6
uniprot id: A0A8I3Q1N8
names: Similarity
messages: Belongs to the SIKE family.

9615:KHDRBS3
gene id: 9615:KHDRBS3
uniprot id: A0A8C0Q9I0
uniprot id: A0A8C0Q9T8
uniprot id: A0A8I3NCN4
uniprot id: A0A8I3RYF3
names: Similarity
messages: Belongs to the KHDRBS family.

9615:AVPR1B
gene id: 9615:AVPR1B
uniprot id: A0A8P0NC80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9615:GALM
gene id: 9615:GALM
uniprot id: A0A8C0TUM9
uniprot id: A0A8I3PB48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

9615:PRR5
gene id: 9615:PRR5
uniprot id: A0A8P0PL36
names: Similarity
messages: Belongs to the PROTOR family.

9615:MRPL43
gene id: 9615:MRPL43
uniprot id: A0A8C0TA55
uniprot id: A0A8I3P6K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9615:DHRS7
gene id: 9615:DHRS7
uniprot id: A0A8C0RXB8
uniprot id: A0A8I3PDJ3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:LOC489590
gene id: 9615:LOC489590
uniprot id: A0A8C0LY03
uniprot id: A0A8I3NXM3
names: Subcellular Location Annotation
messages: Membrane

9615:EHHADH
gene id: 9615:EHHADH
uniprot id: A0A8C0Z6V0
uniprot id: A0A8I3SCF0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9615:COL4A6
gene id: 9615:COL4A6
uniprot id: A0A8C0S7W3
uniprot id: A0A8P0NJE3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9615:GRHL2
gene id: 9615:GRHL2
uniprot id: A0A8C0Q8W8
uniprot id: A0A8I3RV92
names: Subcellular Location Annotation
messages: Nucleus

9615:RPL14
gene id: 9615:RPL14
uniprot id: A0A8C0RIY8
uniprot id: A0A8I3RZN5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9615:ACOX3
gene id: 9615:ACOX3
uniprot id: A0A8P0T7N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9615:MRPL24
gene id: 9615:MRPL24
uniprot id: A0A8C0M0D1
uniprot id: A0A8I3MXF1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9615:ERCC5
gene id: 9615:ERCC5
uniprot id: A0A8P0SVU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

9615:ERAL1
gene id: 9615:ERAL1
uniprot id: A0A8C0MZS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

9615:SUV39H1
gene id: 9615:SUV39H1
uniprot id: A0A8C0NJF8
uniprot id: A0A8I3Q5G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9615:PPP1R3C
gene id: 9615:PPP1R3C
uniprot id: A0A8C0T1I3
uniprot id: A0A8I3Q3Y6
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9615:TRADD
gene id: 9615:TRADD
uniprot id: A0A8C0T0X4
uniprot id: A0A8I3NEJ2
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

9615:CADM2
gene id: 9615:CADM2
uniprot id: A0A8I3PTC6
uniprot id: A0A8I3SA59
names: Similarity
messages: Belongs to the nectin family.

9615:ALG5
gene id: 9615:ALG5
uniprot id: A0A8C0S4S5
uniprot id: A0A8I3Q061
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9615:ARSB
gene id: 9615:ARSB
uniprot id: A0A8C0NJ58
uniprot id: Q32KI4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:DOLK
gene id: 9615:DOLK
uniprot id: A0A8C0MGL2
uniprot id: A0A8P0NZG1
names: Similarity
messages: Belongs to the polyprenol kinase family.

9615:NETO1
gene id: 9615:NETO1
uniprot id: A0A8C0LYC5
uniprot id: A0A8I3MHI4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PICK1
gene id: 9615:PICK1
uniprot id: A0A8C0NFZ2
uniprot id: A0A8I3PU21
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9615:TDO2
gene id: 9615:TDO2
uniprot id: A0A8C0RE89
uniprot id: A0A8I3NIH8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MRPS14
gene id: 9615:MRPS14
uniprot id: A0A8C0S772
uniprot id: A0A8I3RY27
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9615:MLF2
gene id: 9615:MLF2
uniprot id: A0A8C0PBK4
uniprot id: A0A8I3PYK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9615:ATXN10
gene id: 9615:ATXN10
uniprot id: A0A8C0YRB2
uniprot id: A0A8I3NI83
names: Function
names: Similarity
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.

9615:NEUROD2
gene id: 9615:NEUROD2
uniprot id: A0A8C0RVT8
uniprot id: A0A8I3NNC4
names: Subcellular Location Annotation
messages: Nucleus

9615:ST3GAL5
gene id: 9615:ST3GAL5
uniprot id: A0A8C0T5R4
uniprot id: A0A8I3NNC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:CYP1A1
gene id: 9615:CYP1A1
uniprot id: A0A0U2PTV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9615:PER3
gene id: 9615:PER3
uniprot id: A0A8P0PNZ3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:TAF8
gene id: 9615:TAF8
uniprot id: A0A8C0RYJ3
uniprot id: A0A8I3NZ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9615:DOLPP1
gene id: 9615:DOLPP1
uniprot id: A0A8C0S5H0
uniprot id: A0A8I3PL72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9615:TNFSF10
gene id: 9615:TNFSF10
uniprot id: B4XH66
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9615:SDC4
gene id: 9615:SDC4
uniprot id: A0A8C0TU12
uniprot id: A0A8I3NWG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Membrane

9615:PTAFR
gene id: 9615:PTAFR
uniprot id: A0A8C0Q1F4
uniprot id: A0A8I3NSH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9615:PRPS2
gene id: 9615:PRPS2
uniprot id: A0A8C0RG12
uniprot id: A0A8I3QL09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9615:MCHR2
gene id: 9615:MCHR2
uniprot id: Q8MIP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:CYP2C18
gene id: 9615:CYP2C18
uniprot id: A0A8P0NAD2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:CHST3
gene id: 9615:CHST3
uniprot id: A0A8C0PUP3
uniprot id: E2RLE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9615:DDIT4
gene id: 9615:DDIT4
uniprot id: A0A8C0Q2K7
uniprot id: A0A8I3N0L7
names: Similarity
messages: Belongs to the DDIT4 family.

9615:GDAP1L1
gene id: 9615:GDAP1L1
uniprot id: A0A8I3P089
names: Similarity
messages: Belongs to the GST superfamily.

9615:ESCO1
gene id: 9615:ESCO1
uniprot id: A0A8C0NM31
uniprot id: A0A8C0NNQ4
uniprot id: A0A8C0NS45
names: Subcellular Location Annotation
messages: Nucleus

9615:SDR42E1
gene id: 9615:SDR42E1
uniprot id: A0A8P0NQ07
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9615:OR11G9
gene id: 9615:OR11G9
uniprot id: A0A8C0QGC7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ADGRD1
gene id: 9615:ADGRD1
uniprot id: A0A8I3Q1L5
uniprot id: A0A8I3QJJ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:BRF2
gene id: 9615:BRF2
uniprot id: A0A8C0SA95
uniprot id: A0A8I3NRI4
names: Similarity
messages: Belongs to the TFIIB family.

9615:ABCB6
gene id: 9615:ABCB6
uniprot id: A0A8P0PCQ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: extracellular exosome
messages: multivesicular body membrane

9615:NDST2
gene id: 9615:NDST2
uniprot id: A0A8C0MWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9615:DCN
gene id: 9615:DCN
uniprot id: Q29393
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).
messages: May affect the rate of fibrils formation.
messages: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
messages: extracellular matrix

9615:OR10Q1
gene id: 9615:OR10Q1
uniprot id: A0A8C0SF73
uniprot id: A0A8I3PCT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:B3GAT2
gene id: 9615:B3GAT2
uniprot id: Q5CAZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins.

9615:OGG1
gene id: 9615:OGG1
uniprot id: A0A8I3RV29
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9615:CPLX2
gene id: 9615:CPLX2
uniprot id: A0A8C0M3F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9615:UTP6
gene id: 9615:UTP6
uniprot id: A0A8C0RNV3
uniprot id: A0A8I3NST8
names: Similarity
messages: Belongs to the UTP6 family.

9615:LOC610636
gene id: 9615:LOC610636
uniprot id: A0A8C0TTK7
uniprot id: A0A8I3SCG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9615:MRPL17
gene id: 9615:MRPL17
uniprot id: A0A8C0N9W0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9615:LOC611401
gene id: 9615:LOC611401
uniprot id: A0A8C0PEP2
uniprot id: A0A8P0SUA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9615:ST8SIA2
gene id: 9615:ST8SIA2
uniprot id: A0A8C0M473
uniprot id: A2BCP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:VAX1
gene id: 9615:VAX1
uniprot id: A0A8C0TX53
uniprot id: A0A8I3QCK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

9615:PKIA
gene id: 9615:PKIA
uniprot id: A0A8C0RIW6
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9615:CHRM5
gene id: 9615:CHRM5
uniprot id: A0A8C0P4S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9615:IL21
gene id: 9615:IL21
uniprot id: Q6L7I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
messages: Secreted

9615:LOC612779
gene id: 9615:LOC612779
uniprot id: A0A8C0QGZ7
uniprot id: A0A8I3RQJ9
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:SLC66A3
gene id: 9615:SLC66A3
uniprot id: A0A8C0MN56
uniprot id: A0A8I3S690
names: Subcellular Location Annotation
messages: Membrane

9615:GUCA2A
gene id: 9615:GUCA2A
uniprot id: A0A8C0PMF7
uniprot id: A0A8I3P3W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9615:SLC35B3
gene id: 9615:SLC35B3
uniprot id: A0A8I3P444
uniprot id: A0A8I3P5Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9615:SLC16A6
gene id: 9615:SLC16A6
uniprot id: A0A8C0LXV2
uniprot id: A0A8I3PZQ2
names: Subcellular Location Annotation
messages: Membrane

9615:DVL2
gene id: 9615:DVL2
uniprot id: A0A8C0Q697
uniprot id: A0A8I3S1H6
names: Similarity
messages: Belongs to the DSH family.

9615:ACP5
gene id: 9615:ACP5
uniprot id: A0A8C0SQS6
uniprot id: E2RBY6
names: Cofactor
messages: Binds 2 iron ions per subunit.

9615:TP53INP1
gene id: 9615:TP53INP1
uniprot id: A0A8C0Z4I6
uniprot id: A0A8P0PGI9
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9615:DMC1
gene id: 9615:DMC1
uniprot id: A0A8C0Q9Z7
uniprot id: A0A8I3S7E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

9615:PTGS2
gene id: 9615:PTGS2
uniprot id: Q8SPQ9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane
messages: Nucleus inner membrane
messages: Nucleus outer membrane

9615:ALOX5
gene id: 9615:ALOX5
uniprot id: E7ECW0
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CHIA
gene id: 9615:CHIA
uniprot id: A0A8C0SEX3
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9615:LOC474791
gene id: 9615:LOC474791
uniprot id: A0A8C0NV70
uniprot id: A0A8I3N3M3
names: Similarity
messages: Belongs to the NipSnap family.

9615:TRPM7
gene id: 9615:TRPM7
uniprot id: A0A8C0T9K7
uniprot id: A0A8I3PPS5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

9615:SNX2
gene id: 9615:SNX2
uniprot id: A0A8I3RW49
names: Similarity
messages: Belongs to the sorting nexin family.

9615:F7
gene id: 9615:F7
uniprot id: Q38J75
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of a light chain and a heavy chain linked by a disulfide bond.
messages: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:AP3M2
gene id: 9615:AP3M2
uniprot id: A0A8C0QC13
uniprot id: A0A8I3N2X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9615:TAF7
gene id: 9615:TAF7
uniprot id: A0A8C0R966
uniprot id: A0A8I3MP84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9615:EGFL8
gene id: 9615:EGFL8
uniprot id: A0A8C0NPA0
uniprot id: A0A8P0N3Z6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:GRIK3
gene id: 9615:GRIK3
uniprot id: A0A8C0RP23
uniprot id: A0A8I3QTN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9615:CDC20
gene id: 9615:CDC20
uniprot id: A0A8C0QF33
uniprot id: A0A8I3NZ86
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9615:CNN2
gene id: 9615:CNN2
uniprot id: A0A8C0NVP6
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9615:CCDC130
gene id: 9615:CCDC130
uniprot id: A0A8C0Z360
uniprot id: A0A8I3Q0W3
names: Similarity
messages: Belongs to the CWC16 family.

9615:TRAPPC6A
gene id: 9615:TRAPPC6A
uniprot id: A0A8C0M9Y4
uniprot id: A0A8P0PMY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9615:DHX8
gene id: 9615:DHX8
uniprot id: A0A8C0LYS1
names: Subcellular Location Annotation
messages: Nucleus

9615:ADPRHL1
gene id: 9615:ADPRHL1
uniprot id: A0A8C0S7F5
uniprot id: A0A8I3PQJ1
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9615:PRICKLE3
gene id: 9615:PRICKLE3
uniprot id: A0A8C0SCG0
uniprot id: A0A8I3QDP0
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9615:OAT
gene id: 9615:OAT
uniprot id: A0A8C0T769
uniprot id: A0A8P0NN46
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9615:SPTLC2
gene id: 9615:SPTLC2
uniprot id: A0A8C0T254
uniprot id: A0A8I3N8H8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9615:CCT2
gene id: 9615:CCT2
uniprot id: A0A8C0QNN5
uniprot id: A0A8I3NY48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9615:OR4K6
gene id: 9615:OR4K6
uniprot id: A0A8C0THY2
uniprot id: A0A8I3S2R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CCNY
gene id: 9615:CCNY
uniprot id: A0A8C0PJW0
uniprot id: A0A8I3MYX8
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9615:CSNK2B
gene id: 9615:CSNK2B
uniprot id: A0A8C0RCK5
uniprot id: A0A8I3NFB2
uniprot id: A0A8I3NIN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9615:TAF1
gene id: 9615:TAF1
uniprot id: A0A8C0S4Q1
uniprot id: A0A8P0SL75
uniprot id: A0A8P0T3E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

9615:PRKCE
gene id: 9615:PRKCE
uniprot id: A0A8C0MXM3
uniprot id: A0A8C0YQX9
uniprot id: A0A8I3Q258
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

9615:CLDN24
gene id: 9615:CLDN24
uniprot id: A0A8C0N3V6
uniprot id: A0A8I3P0C6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:GPR20
gene id: 9615:GPR20
uniprot id: A0A8C0QIX1
uniprot id: A0A8P0TKK2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:SLC25A42
gene id: 9615:SLC25A42
uniprot id: A0A8C0NCF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:UBL3
gene id: 9615:UBL3
uniprot id: A0A8C0PE62
uniprot id: A0A8I3PJ86
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:HAL
gene id: 9615:HAL
uniprot id: A0A8C0P4P3
uniprot id: A0A8I3Q1B2
names: Similarity
messages: Belongs to the PAL/histidase family.

9615:LYZ
gene id: 9615:LYZ
uniprot id: G1K265
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

9615:NEUROD4
gene id: 9615:NEUROD4
uniprot id: A0A8C0T0H8
uniprot id: A0A8I3NN90
names: Subcellular Location Annotation
messages: Nucleus

9615:RPS6KA1
gene id: 9615:RPS6KA1
uniprot id: A0A8C0N7U1
uniprot id: A0A8C0QBW0
uniprot id: A0A8I3NKU8
uniprot id: A0A8I3NMQ4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9615:BRINP3
gene id: 9615:BRINP3
uniprot id: A0A8C0RS47
uniprot id: A0A8I3PMY2
names: Similarity
messages: Belongs to the BRINP family.

9615:CENPU
gene id: 9615:CENPU
uniprot id: A0A8C0SI06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-U/AME1 family.
messages: Nucleus

9615:OR52AB2
gene id: 9615:OR52AB2
uniprot id: A0A8I3P9H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CHD2
gene id: 9615:CHD2
uniprot id: A0A8C0MA63
uniprot id: A0A8C0TTC3
uniprot id: A0A8P0ND39
uniprot id: A0A8P0SSI9
names: Subcellular Location Annotation
messages: Nucleus

9615:FAM187A
gene id: 9615:FAM187A
uniprot id: A0A8C0MFG8
uniprot id: A0A8I3N351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9615:LIF
gene id: 9615:LIF
uniprot id: A0A8C0RQT8
uniprot id: A0A8I3Q5S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

9615:SLA
gene id: 9615:SLA
uniprot id: A0A8C0NQK4
uniprot id: A0A8C0NW58
uniprot id: A0A8C0P1Z9
uniprot id: A0A8I3RV77
names: Subcellular Location Annotation
messages: Cytoplasm

9615:H3-3A
gene id: 9615:H3-3A
uniprot id: A0A8C0LQ69
uniprot id: E2R6K5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:LAMA3
gene id: 9615:LAMA3
uniprot id: A0A8P0TG28
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PPP3R1
gene id: 9615:PPP3R1
uniprot id: A0A8C0RKV1
uniprot id: A0A8I3PQY6
uniprot id: A0A8P0TRD4
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9615:GADD45GIP1
gene id: 9615:GADD45GIP1
uniprot id: A0A8C0P5A7
uniprot id: A0A8I3P0B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

9615:CYP39A1
gene id: 9615:CYP39A1
uniprot id: A0A8C0SF29
uniprot id: A0A8I3NQ76
uniprot id: A0A8I3RX90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9615:MRPS21
gene id: 9615:MRPS21
uniprot id: A0A8C0MI93
uniprot id: A0A8I3RZJ6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9615:MRPL14
gene id: 9615:MRPL14
uniprot id: A0A8C0S4D6
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9615:CCNYL1
gene id: 9615:CCNYL1
uniprot id: A0A8C0N277
uniprot id: A0A8C0TYE7
uniprot id: A0A8I3PBG6
uniprot id: A0A8I3PF40
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9615:RPS6KA4
gene id: 9615:RPS6KA4
uniprot id: A0A8C0RIW5
uniprot id: A0A8I3Q6K1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9615:RHO
gene id: 9615:RHO
uniprot id: A0A8C0P150
uniprot id: A0A8I3QE57
uniprot id: P32308
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.
messages: Defects in RHO are a cause of autosomal dominant retinitis pigmentosa (ADRP). The phenotypic features shared by dog and man include a dramatically slowed time course of recovery of rod photoreceptor function after light exposure and a distinctive topographic pattern to the retinal degeneration. This disease was identified in the English mastiff breed.
messages: Homodimer (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts with GRK1 (By similarity). Interacts (phosphorylated form) with SAG. Interacts with GNAT1. Interacts with GNAT3. SAG and G-proteins compete for a common binding site (By similarity). Interacts with PRCD; the interaction promotes PRCD stability.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (PubMed:11972042). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
messages: photoreceptor outer segment

9615:SIAH1
gene id: 9615:SIAH1
uniprot id: A0A8C0SRQ4
uniprot id: A0A8C0YZ25
uniprot id: A0A8I3MT88
uniprot id: A0A8I3MTY8
uniprot id: A0A8I3RS36
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9615:SSR4
gene id: 9615:SSR4
uniprot id: A0A8C0NNM2
uniprot id: A0A8I3PXW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9615:MITF
gene id: 9615:MITF
uniprot id: A0A8C0YSP0
uniprot id: Q864F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9615:HAMP
gene id: 9615:HAMP
uniprot id: Q5U9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hepcidin family.
messages: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
messages: Interacts with SLC40A1; this interaction promotes SLC40A1 rapid ubiquitination.
messages: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
messages: Secreted

9615:CYP24A1
gene id: 9615:CYP24A1
uniprot id: A0A8P0NE13
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:SEMA3D
gene id: 9615:SEMA3D
uniprot id: A0A8C0N1G0
uniprot id: A0A8I3Q2U6
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ZKSCAN5
gene id: 9615:ZKSCAN5
uniprot id: A0A8C0S0K9
uniprot id: A0A8I3MNS6
uniprot id: A0A8I3MQA5
names: Subcellular Location Annotation
messages: Nucleus

9615:NDUFB8
gene id: 9615:NDUFB8
uniprot id: A0A8I3NUH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:GPRIN3
gene id: 9615:GPRIN3
uniprot id: A0A8P0NC12
names: Function
messages: May be involved in neurite outgrowth.

9615:BID
gene id: 9615:BID
uniprot id: A0A140DDD1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:LRRC8B
gene id: 9615:LRRC8B
uniprot id: A0A8C0RND8
uniprot id: A0A8I3P935
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9615:PRKCZ
gene id: 9615:PRKCZ
uniprot id: A0A8C0QAW8
uniprot id: A0A8P0T684
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9615:CD163
gene id: 9615:CD163
uniprot id: Q2VLG6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs (By similarity).
messages: After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
messages: Cell membrane
messages: Interacts with CSNK2B.
messages: Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).
messages: Phosphorylated.
messages: Secreted
messages: The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.

9615:SLC25A31
gene id: 9615:SLC25A31
uniprot id: A0A8C0MP15
uniprot id: A0A8I3P406
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9615:MRPL32
gene id: 9615:MRPL32
uniprot id: A0A8C0MFI8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9615:H2AC1
gene id: 9615:H2AC1
uniprot id: A0A8C0NXK7
uniprot id: A0A8I3PQ44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:UBR1
gene id: 9615:UBR1
uniprot id: A0A8C0RPV6
uniprot id: A0A8I3P974
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9615:SCAMP1
gene id: 9615:SCAMP1
uniprot id: A0A8C0PNV9
uniprot id: A0A8I3N2P5
uniprot id: A0A8I3N7Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9615:IL1RL1
gene id: 9615:IL1RL1
uniprot id: A0A8C0QGS0
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9615:DSTYK
gene id: 9615:DSTYK
uniprot id: Q4VSN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm

9615:HOXA1
gene id: 9615:HOXA1
uniprot id: A0A8C0S461
uniprot id: A0A8I3ND85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9615:CCR10
gene id: 9615:CCR10
uniprot id: A0A8C0RZT2
uniprot id: A0A8I3N349
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:EMC3
gene id: 9615:EMC3
uniprot id: A0A8C0RDQ2
uniprot id: A0A8I3MZ54
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9615:BAZ1A
gene id: 9615:BAZ1A
uniprot id: A0A8C0MMS2
uniprot id: A0A8C0SR45
uniprot id: A0A8I3ME85
uniprot id: A0A8I3MM15
names: Subcellular Location Annotation
messages: Nucleus

9615:MRTO4
gene id: 9615:MRTO4
uniprot id: A0A8C0RFL6
uniprot id: A0A8I3MKC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9615:CMBL
gene id: 9615:CMBL
uniprot id: A0A8I3P8N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9615:LOC607286
gene id: 9615:LOC607286
uniprot id: A0A8C0S226
uniprot id: A0A8I3RX92
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9615:ARPC4
gene id: 9615:ARPC4
uniprot id: A0A8C0TNK7
uniprot id: A0A8I3N156
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9615:AZIN2
gene id: 9615:AZIN2
uniprot id: A0A8C0T507
uniprot id: A0A8I3MN71
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9615:CAV2
gene id: 9615:CAV2
uniprot id: O46550
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
messages: Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).
messages: Most abundant form.
messages: Nucleus
messages: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).
messages: caveola

9615:KLC1
gene id: 9615:KLC1
uniprot id: A0A8C0SGV3
uniprot id: A0A8C0SHY2
uniprot id: A0A8C0YX05
uniprot id: A0A8I3NY52
uniprot id: A0A8I3P4G7
uniprot id: A0A8I3P532
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9615:TTC36
gene id: 9615:TTC36
uniprot id: A0A8C0PU42
uniprot id: A0A8I3N0L1
names: Similarity
messages: Belongs to the TTC36 family.

9615:PABPN1
gene id: 9615:PABPN1
uniprot id: A0A8C0Q946
uniprot id: A0A8I3MVB8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:BBOF1
gene id: 9615:BBOF1
uniprot id: A0A8C0NZI3
uniprot id: A0A8C0NZN6
uniprot id: A0A8C0P5S5
uniprot id: A0A8I3P179
uniprot id: A0A8P0NU31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
messages: Belongs to the BBOF1 family.
messages: cilium basal body

9615:CHD7
gene id: 9615:CHD7
uniprot id: A0A8C0SYB8
uniprot id: A0A8I3PXJ5
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9615:SEC62
gene id: 9615:SEC62
uniprot id: A0A8C0PZV5
uniprot id: A0A8I3PCD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:HYLS1
gene id: 9615:HYLS1
uniprot id: A0A8C0SVU6
uniprot id: A0A8I3RXP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

9615:BRK1
gene id: 9615:BRK1
uniprot id: A0A8C0TQT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: cytoskeleton

9615:RPS27
gene id: 9615:RPS27
uniprot id: A0A8C0P2Q4
uniprot id: A0A8I3NWH5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9615:VPS37D
gene id: 9615:VPS37D
uniprot id: A0A8C0S8R6
uniprot id: A0A8I3N530
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9615:GPI
gene id: 9615:GPI
uniprot id: A0A8C0M159
uniprot id: A0A8I3RTC4
names: Similarity
messages: Belongs to the GPI family.

9615:DBT
gene id: 9615:DBT
uniprot id: A0A8C0NJC4
uniprot id: A0A8I3NPD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9615:ADCK1
gene id: 9615:ADCK1
uniprot id: A0A8P0P2S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Secreted

9615:C7H18orf32
gene id: 9615:C7H18orf32
uniprot id: A0A8C0M0N8
uniprot id: A0A8I3S263
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

9615:PRPSAP1
gene id: 9615:PRPSAP1
uniprot id: A0A8P0SYU6
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9615:RNF141
gene id: 9615:RNF141
uniprot id: Q2XNS1
names: Function
names: Subcellular Location Annotation
messages: May be involved in spermatogenesis.
messages: Membrane

9615:WDR35
gene id: 9615:WDR35
uniprot id: A0A8C0NIA4
names: Function
names: Subcellular Location Annotation
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: centrosome
messages: cilium basal body

9615:FBL
gene id: 9615:FBL
uniprot id: A0A8I3MM38
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9615:ATP8A1
gene id: 9615:ATP8A1
uniprot id: A0A8C0RI23
uniprot id: A0A8I3NQB5
uniprot id: A0A8P0NRA1
uniprot id: A0A8P0NVF5
uniprot id: A0A8P0THG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:UCP3
gene id: 9615:UCP3
uniprot id: F1PWF9
uniprot id: Q9N2I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity).

9615:ERRFI1
gene id: 9615:ERRFI1
uniprot id: A0A8C0SGD8
uniprot id: A0A8I3S6C0
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9615:SOX3
gene id: 9615:SOX3
uniprot id: A0A8C0SIP7
uniprot id: A0A8P0SND0
names: Subcellular Location Annotation
messages: Nucleus

9615:LOC487083
gene id: 9615:LOC487083
uniprot id: A0A8C0MSQ6
uniprot id: E2RR82
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9615:FAM210A
gene id: 9615:FAM210A
uniprot id: A0A8C0M4A6
uniprot id: A0A8I3RRE4
names: Similarity
messages: Belongs to the FAM210 family.

9615:TOB2
gene id: 9615:TOB2
uniprot id: A0A8C0Z0N9
uniprot id: A0A8I3S2H5
names: Similarity
messages: Belongs to the BTG family.

9615:WDR82
gene id: 9615:WDR82
uniprot id: A0A8C0TCN1
uniprot id: A0A8I3QC53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9615:INSIG1
gene id: 9615:INSIG1
uniprot id: A0A8C0RNL3
uniprot id: A0A8I3NKC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9615:MED28
gene id: 9615:MED28
uniprot id: A0A8I3MAU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9615:DAD1
gene id: 9615:DAD1
uniprot id: A0A8C0PLL8
uniprot id: A0A8I3MLJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9615:NELFE
gene id: 9615:NELFE
uniprot id: A0A8I3NRP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

9615:TRAF2
gene id: 9615:TRAF2
uniprot id: A0A8C0MD65
uniprot id: A0A8I3MQC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9615:CCNG2
gene id: 9615:CCNG2
uniprot id: A0A8C0T3F8
uniprot id: A0A8I3P5A8
names: Similarity
messages: Belongs to the cyclin family.

9615:CBR3
gene id: 9615:CBR3
uniprot id: A0A8C0PJ32
uniprot id: A0A8I3PRW1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9615:PRKAR1A
gene id: 9615:PRKAR1A
uniprot id: A0A8C0S5L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9615:CDX2
gene id: 9615:CDX2
uniprot id: A0A8C0P362
uniprot id: A0A8I3PU71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9615:AMZ2
gene id: 9615:AMZ2
uniprot id: A0A8C0LST9
uniprot id: A0A8P0ND50
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9615:UQCC1
gene id: 9615:UQCC1
uniprot id: A0A8C0P9S5
uniprot id: A0A8C0QEE5
uniprot id: A0A8I3P513
uniprot id: A0A8I3P9D9
uniprot id: A0A8P0SD86
names: Similarity
messages: Belongs to the CBP3 family.

9615:GFUS
gene id: 9615:GFUS
uniprot id: A0A8C0PE64
uniprot id: A0A8I3P1I1
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9615:ARL3
gene id: 9615:ARL3
uniprot id: A0A8C0RSR4
uniprot id: A0A8P0NC94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9615:SOD2
gene id: 9615:SOD2
uniprot id: A0A346M2B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

9615:KCNE3
gene id: 9615:KCNE3
uniprot id: A0A8C0T3Q1
uniprot id: A0A8I3MYQ7
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9615:SRSF5
gene id: 9615:SRSF5
uniprot id: A0A8C0SL37
uniprot id: A0A8I3MM59
names: Similarity
messages: Belongs to the splicing factor SR family.

9615:LMNA
gene id: 9615:LMNA
uniprot id: A0A8C0TCD0
uniprot id: A0A8I3NEK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9615:RPAIN
gene id: 9615:RPAIN
uniprot id: A0A8C0PMX5
uniprot id: A0A8C0RUW1
uniprot id: A0A8C0RUW6
uniprot id: A0A8I3MK19
uniprot id: A0A8I3RQY0
names: Subcellular Location Annotation
messages: Nucleus

9615:SLC39A8
gene id: 9615:SLC39A8
uniprot id: A0A8C0P5E2
uniprot id: A0A8P0SFM6
names: Subcellular Location Annotation
messages: Membrane

9615:PTH
gene id: 9615:PTH
uniprot id: P52212
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
messages: Secreted

9615:TMEM88B
gene id: 9615:TMEM88B
uniprot id: A0A8I3PKE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9615:CD40
gene id: 9615:CD40
uniprot id: Q7YRL5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).
messages: Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).

9615:ZDHHC20
gene id: 9615:ZDHHC20
uniprot id: A0A8C0PJ41
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:DEFB110
gene id: 9615:DEFB110
uniprot id: A0A8C0Q9I2
uniprot id: Q30KU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:MTMR4
gene id: 9615:MTMR4
uniprot id: A0A8C0MQ27
uniprot id: A0A8C0PTK9
uniprot id: A0A8I3PDB6
uniprot id: A0A8I3S4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9615:MAPRE1
gene id: 9615:MAPRE1
uniprot id: A0A8C0RYJ4
uniprot id: A0A8I3PST2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

9615:LOC483802
gene id: 9615:LOC483802
uniprot id: A0A8P0SKL2
names: Similarity
messages: Belongs to the peptidase A1 family.

9615:TBX21
gene id: 9615:TBX21
uniprot id: A0A8C0Q056
uniprot id: A0A8I3P525
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:SGK2
gene id: 9615:SGK2
uniprot id: A0A8C0TPC2
uniprot id: A0A8P0TBP8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:SMC4
gene id: 9615:SMC4
uniprot id: A0A8C0NGA8
uniprot id: A0A8I3Q1Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

9615:PTPN13
gene id: 9615:PTPN13
uniprot id: A0A8P0NV17
uniprot id: A0A8P0P7B7
uniprot id: A0A8P0T3Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
messages: cytoskeleton

9615:TRAPPC3
gene id: 9615:TRAPPC3
uniprot id: A0A8C0NV30
uniprot id: A0A8I3QC45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9615:MRPL13
gene id: 9615:MRPL13
uniprot id: A0A8C0SA73
uniprot id: A0A8P0N468
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9615:C5H1orf174
gene id: 9615:C5H1orf174
uniprot id: A0A8C0M2W8
uniprot id: A0A8I3P6R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9615:OTUD7B
gene id: 9615:OTUD7B
uniprot id: A0A8P0SGI8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:GAPDH
gene id: 9615:GAPDH
uniprot id: A0A8I3Q5N9
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9615:PLOD3
gene id: 9615:PLOD3
uniprot id: A0A8I3MZE0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9615:FES
gene id: 9615:FES
uniprot id: A0A8C0RWB5
uniprot id: A0A8I3MKV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

9615:RABAC1
gene id: 9615:RABAC1
uniprot id: Q8HY39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA1 family.
messages: Cell membrane
messages: Cytoplasm
messages: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1.
messages: Golgi apparatus
messages: Homodimer. Interacts with VAMP2 (synaptobrevin-2), prenylated Rab proteins, GDI1, NDRG1 and PCLO (By similarity).
messages: synaptic vesicle

9615:KIF4A
gene id: 9615:KIF4A
uniprot id: A0A8C0THV7
uniprot id: A0A8I3Q5Y5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:TAP2
gene id: 9615:TAP2
uniprot id: H8ZYY8
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

9615:CSNK1A1
gene id: 9615:CSNK1A1
uniprot id: A0A8C0SDG5
uniprot id: A0A8I3N6W0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:YY1
gene id: 9615:YY1
uniprot id: A0A8C0Q4Q1
uniprot id: A0A8I3MKF1
names: Similarity
messages: Belongs to the YY transcription factor family.

9615:FAM135A
gene id: 9615:FAM135A
uniprot id: A0A8C0P3W7
uniprot id: A0A8C0Q6V1
uniprot id: A0A8I3N5X5
uniprot id: A0A8I3NMZ5
names: Similarity
messages: Belongs to the FAM135 family.

9615:GSTO2
gene id: 9615:GSTO2
uniprot id: A0A8C0TQC5
uniprot id: A0A8C0TQR0
uniprot id: A0A8I3PJI7
uniprot id: A0A8I3S3X7
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9615:VIPR2
gene id: 9615:VIPR2
uniprot id: A0A8C0PGB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9615:CTNNB1
gene id: 9615:CTNNB1
uniprot id: B6V8E6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-catenin family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Deacetylated at Lys-49 by SIRT1.
messages: Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity).
messages: Nucleus
messages: O-glycosylation at Ser-23 decreases nuclear localization and transcriptional activity, and increases localization to the plasma membrane and interaction with E-cadherin CDH1.
messages: Phosphorylation by GSK3B requires prior phosphorylation of Ser-45 by another kinase. Phosphorylation proceeds then from Thr-41 to Ser-33. Phosphorylated by NEK2. EGF stimulates tyrosine phosphorylation. Phosphorylated on Ser-33 and Ser-37 by HIPK2. This phosphorylation triggers proteasomal degradation. Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription. Phosphorylation on Ser-191 and Ser-246 by CDK5. Phosphorylation by CDK2 regulates insulin internalization. Phosphorylation by PTK6 at Tyr-64, Tyr-142, Tyr-331 and/or Tyr-333 with the predominant site at Tyr-64 is not essential for inhibition of transcriptional activity. Phosphorylation by SRC at Tyr-333 promotes interaction with isoform M2 of PKM (PKM2); promoting transcription activation.
messages: S-nitrosylation at Cys-619 within adherens junctions promotes VEGF-induced, NO-dependent endothelial cell permeability by disrupting interaction with E-cadherin, thus mediating disassembly adherens junctions.
messages: Synapse
messages: Two separate complex-associated pools are found in the cytoplasm. The majority is present as part of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and beta-catenin/CTNNB1, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Binds SLC9A3R1. Interacts with PTPRU (via the cytoplasmic juxtamembrane domain) and with EMD. Interacts with SESTD1 and TRPC4. Interacts with CAV1. Interacts with PTPRJ. Interacts with PKT7. Interacts with FAT1 (via the cytoplasmic domain). Interacts with CDK2, NDRG2 and NANOS1. Interacts with NEK2 and CDK5. Interacts with CARM1, CXADR, PCDH11Y and PTK6. Interacts with SOX7; this interaction may lead to proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Identified in a complex with HINT1 and MITF. Interacts with FHIT. Interacts with FERMT2. Identified in a complex with TCF4 and FERMT2. Another cytoplasmic pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited, the complex disassociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF-1 family members, BCL9, BCL9L and possibly also RUVBL1 and CHD8. Interacts with TAX1BP3 (via the PDZ domain); this interaction inhibits the transcriptional activity of CTNNB1. Interacts with AJAP1, BAIAP1 and CTNNA3. Interacts with TRPV4; the TRPV4 and CTNNB1 complex can interact with CDH1. Interacts with VCL. The …
messages: Ubiquitinated by the SCF(BTRC) E3 ligase complex when phosphorylated by GSK3B, leading to its degradation. Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X, leading to its subsequent proteasomal degradation (By similarity). Ubiquitinated and degraded following interaction with SOX9 (By similarity).
messages: adherens junction
messages: centrosome
messages: cilium basal body
messages: cytoskeleton
messages: spindle pole

9615:SF3B3
gene id: 9615:SF3B3
uniprot id: A0A8C0SSU9
uniprot id: A0A8I3MQG0
names: Subcellular Location Annotation
messages: Nucleus

9615:ELF5
gene id: 9615:ELF5
uniprot id: A0A8C0SUN1
uniprot id: A0A8I3PL55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:COMT
gene id: 9615:COMT
uniprot id: Q69FG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
messages: Cell membrane

9615:NDUFS8
gene id: 9615:NDUFS8
uniprot id: A0A8C0PCF8
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

9615:FMO5
gene id: 9615:FMO5
uniprot id: A0A8C0MTQ7
uniprot id: A0A8P0NCV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9615:ST7L
gene id: 9615:ST7L
uniprot id: A0A8P0THN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9615:HSD17B4
gene id: 9615:HSD17B4
uniprot id: A0A8C0Q1M8
uniprot id: A0A8C0RXL9
uniprot id: A0A8I3N3X9
names: Subcellular Location Annotation
messages: Peroxisome

9615:LOC119863874
gene id: 9615:LOC119863874
uniprot id: A0A8C0RZG3
uniprot id: A0A8P0N4Y4
names: Subcellular Location Annotation
messages: Membrane

9615:DLX3
gene id: 9615:DLX3
uniprot id: A0A8C0LWI6
uniprot id: A0A8I3RWQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9615:COQ9
gene id: 9615:COQ9
uniprot id: A0A8I3RSQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9615:TGIF2
gene id: 9615:TGIF2
uniprot id: A0A8C0SCM7
uniprot id: A0A8I3PWZ5
names: Subcellular Location Annotation
messages: Nucleus

9615:RPS19
gene id: 9615:RPS19
uniprot id: A0A8C0RBJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

9615:IL6R
gene id: 9615:IL6R
uniprot id: A0A8C0PF44
uniprot id: A0A8I3NUE0
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9615:PPDPFL
gene id: 9615:PPDPFL
uniprot id: A0A8C0TKU7
uniprot id: A0A8I3QPN1
names: Similarity
messages: Belongs to the PPDPF family.

9615:RPS18
gene id: 9615:RPS18
uniprot id: Q5TJE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Cytoplasm
messages: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

9615:CSE1L
gene id: 9615:CSE1L
uniprot id: A0A8C0S3Y6
uniprot id: A0A8I3PFQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9615:SIRT5
gene id: 9615:SIRT5
uniprot id: E2RDZ6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1. Interacts with PCCA (By similarity).
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
messages: Nucleus
messages: cytosol

9615:PTPRB
gene id: 9615:PTPRB
uniprot id: A0A8P0N3P5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9615:PDS5A
gene id: 9615:PDS5A
uniprot id: A0A8C0Z1E0
uniprot id: A0A8I3MSX0
names: Similarity
messages: Belongs to the PDS5 family.

9615:ARFGEF1
gene id: 9615:ARFGEF1
uniprot id: A0A8C0N3I1
uniprot id: A0A8I3PNR5
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9615:RO60
gene id: 9615:RO60
uniprot id: A0A8I3PKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9615:PNPLA1
gene id: 9615:PNPLA1
uniprot id: A0A8P0N4J4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CAPN9
gene id: 9615:CAPN9
uniprot id: A0A8C0NDL3
uniprot id: A0A8I3MDF9
names: Similarity
messages: Belongs to the peptidase C2 family.

9615:CPLX4
gene id: 9615:CPLX4
uniprot id: A0A8C0Q1X4
uniprot id: A0A8I3MKV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9615:RIOK1
gene id: 9615:RIOK1
uniprot id: A0A8C0N685
uniprot id: A0A8I3NZ39
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9615:DOK1
gene id: 9615:DOK1
uniprot id: A0A8P0NAJ2
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9615:MT1E
gene id: 9615:MT1E
uniprot id: O19000
names: Domain
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

9615:LGMN
gene id: 9615:LGMN
uniprot id: A0A8C0LXP0
uniprot id: A0A8P0ND98
names: Similarity
messages: Belongs to the peptidase C13 family.

9615:GINS1
gene id: 9615:GINS1
uniprot id: A0A8C0SLJ8
uniprot id: A0A8I3Q235
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9615:NPVF
gene id: 9615:NPVF
uniprot id: A0A8C0RD01
uniprot id: E2QYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9615:NUMBL
gene id: 9615:NUMBL
uniprot id: A0A8P0N7W8
names: Function
messages: Plays a role in the process of neurogenesis.

9615:NAGPA
gene id: 9615:NAGPA
uniprot id: A0A8I3NX74
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:NUDT7
gene id: 9615:NUDT7
uniprot id: A0A8C0M0L4
uniprot id: A0A8I3PAK1
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9615:DGKQ
gene id: 9615:DGKQ
uniprot id: A0A8I3MGJ8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9615:ATXN7L3
gene id: 9615:ATXN7L3
uniprot id: A0A8C0YZW6
uniprot id: A0A8P0NG50
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

9615:CACNB2
gene id: 9615:CACNB2
uniprot id: A0A8C0MZ52
uniprot id: A0A8C0NCJ5
uniprot id: A0A8C0PWQ1
uniprot id: A0A8I3NEE5
uniprot id: A0A8I3NM47
uniprot id: A0A8I3NR31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
messages: sarcolemma

9615:OR5AC26
gene id: 9615:OR5AC26
uniprot id: A0A8C0NX46
uniprot id: A0A8I3RYZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ARHGEF9
gene id: 9615:ARHGEF9
uniprot id: A0A8C0T7R1
uniprot id: A0A8C0T9V8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
messages: Cytoplasm
messages: Interacts with GPHN.
messages: Postsynaptic density

9615:ALDH8A1
gene id: 9615:ALDH8A1
uniprot id: A0A8C0Q252
uniprot id: A0A8I3NAJ1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:LOC607729
gene id: 9615:LOC607729
uniprot id: A0A8I3NF63
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ACOX2
gene id: 9615:ACOX2
uniprot id: A0A8P0SCI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9615:ATL3
gene id: 9615:ATL3
uniprot id: A0A8C0MPZ3
uniprot id: A0A8I3MUQ3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9615:SEC24D
gene id: 9615:SEC24D
uniprot id: A0A8C0TVC4
uniprot id: A0A8I3SCF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9615:CASP12
gene id: 9615:CASP12
uniprot id: Q075B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits (Potential). May interact with TRAF2 (By similarity).
messages: Involved in the activation cascade of caspases responsible for apoptosis execution.

9615:H2BC15
gene id: 9615:H2BC15
uniprot id: A0A8C0RQ70
uniprot id: J9P6S8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:RAB25
gene id: 9615:RAB25
uniprot id: E2RQ15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer.
messages: Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).
messages: pseudopodium membrane

9615:LSM6
gene id: 9615:LSM6
uniprot id: A0A8C0Q5G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9615:MPV17
gene id: 9615:MPV17
uniprot id: A0A8C0MQ97
uniprot id: A0A8C0S3J0
uniprot id: A0A8I3N2V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9615:NAIF1
gene id: 9615:NAIF1
uniprot id: A0A8C0RIJ0
uniprot id: A0A8I3RTZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

9615:CYP2F1
gene id: 9615:CYP2F1
uniprot id: A0A8C0M3A7
uniprot id: A0A8I3MMW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane
messages: Microsome membrane

9615:MMAB
gene id: 9615:MMAB
uniprot id: A0A8C0TP82
uniprot id: A0A8I3PL52
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

9615:BIRC2
gene id: 9615:BIRC2
uniprot id: Q38JA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9615:CPNE8
gene id: 9615:CPNE8
uniprot id: A0A8I3QZ57
uniprot id: A0A8P0T6D4
names: Similarity
messages: Belongs to the copine family.

9615:DOP1A
gene id: 9615:DOP1A
uniprot id: A0A8C0MGL7
uniprot id: A0A8I3NGS6
uniprot id: A0A8I3RY73
names: Similarity
messages: Belongs to the dopey family.

9615:TMED9
gene id: 9615:TMED9
uniprot id: A0A8C0M7W2
uniprot id: A0A8I3NA58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:PYGL
gene id: 9615:PYGL
uniprot id: A0A8C0Q1A8
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9615:MAB21L2
gene id: 9615:MAB21L2
uniprot id: A0A8C0NP42
uniprot id: A0A8I3N0K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

9615:CXCR6
gene id: 9615:CXCR6
uniprot id: A0A8C0T4E2
uniprot id: A0A8I3RWZ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:AOC3
gene id: 9615:AOC3
uniprot id: A0A8C0TAI5
uniprot id: A0A8I3MYY3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9615:B3GAT3
gene id: 9615:B3GAT3
uniprot id: A0A8C0T8N5
uniprot id: A0A8I3RWN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:GATM
gene id: 9615:GATM
uniprot id: A0A8C0NC71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.
messages: Homodimer.
messages: Mitochondrion inner membrane

9615:RAB7A
gene id: 9615:RAB7A
uniprot id: P18067
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasmic vesicle
messages: Endosome membrane
messages: Interacts with NTRK1/TRKA (By similarity). Interacts with RILP (By similarity). Interacts with PSMA7 (By similarity). Interacts with RNF115 (By similarity). Interacts with FYCO1 (By similarity). Interacts with the PIK3C3/VPS34-PIK3R4 complex (By similarity). The GTP-bound form interacts with OSBPL1A (By similarity). The GTP-bound form interacts with RAC1 (By similarity). Interacts with CLN3 (By similarity). Interacts with CHM, the substrate-binding subunit of the Rab geranylgeranyltransferase complex (By similarity). Interacts with C9orf72. Does not interact with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4). Interacts with CLN5 (By similarity). Interacts with PLEKHM1 (via N- and C-terminus) (By similarity). Interacts with RUFY4 (By similarity). Interacts with PRPH; the interaction is direct (By similarity). Interacts with VPS13A (By similarity). The GDP-bound form interacts with RIMOC1 (By similarity). Interacts with the MON1A-CCZ1B complex and this interaction is enhanced in the presence of RIMOC1 (By similarity).
messages: Late endosome membrane
messages: Lipid droplet
messages: Lysosome membrane
messages: Melanosome membrane
messages: Mitochondrion membrane
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transporter-mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By similarity). Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses (By similarity). Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium) (By similarity). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (By similarity). Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (By similarity). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway. Required for the exosomal release of SDCBP, CD63 and syndecan (By s…
messages: autophagosome membrane
messages: phagosome membrane

9615:MAP2K2
gene id: 9615:MAP2K2
uniprot id: Q1HG70
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).
messages: Cytoplasm
messages: Interacts with MORG1 (By similarity). Interacts with SGK1 (By similarity). Interacts with KSR1. Interacts with KSR1 and BRAF; the interaction with KSR1 mediates KSR1-BRAF dimerization. Interacts with GLS (By similarity).
messages: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
messages: Membrane

9615:TENT5C
gene id: 9615:TENT5C
uniprot id: A0A8I3MZ84
names: Similarity
messages: Belongs to the TENT family.

9615:C11H5orf24
gene id: 9615:C11H5orf24
uniprot id: A0A8I3S0C1
names: Similarity
messages: Belongs to the UPF0461 family.

9615:CALR3
gene id: 9615:CALR3
uniprot id: A0A8C0P9A6
uniprot id: A0A8I3Q2D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9615:MZT1
gene id: 9615:MZT1
uniprot id: A0A8C0RHU5
uniprot id: A0A8I3S595
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9615:SERPINB5
gene id: 9615:SERPINB5
uniprot id: A0A8C0PQP0
uniprot id: A0A8C0RVP4
uniprot id: A0A8I3MKP5
uniprot id: A0A8I3RS64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

9615:PRPF38B
gene id: 9615:PRPF38B
uniprot id: A0A8I3NJZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9615:CCR4
gene id: 9615:CCR4
uniprot id: Q8MJW8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in thymus, spleen, heart, small intestine and lymph node.
messages: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival (By similarity).
messages: In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.

9615:ZNF444
gene id: 9615:ZNF444
uniprot id: A0A8C0RAJ6
uniprot id: A0A8I3MAC5
names: Subcellular Location Annotation
messages: Nucleus

9615:CLK4
gene id: 9615:CLK4
uniprot id: A0A8C0M9N7
uniprot id: A0A8I3N167
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:DDX58
gene id: 9615:DDX58
uniprot id: A0A8C0QM78
uniprot id: A0A8P0N4Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9615:OR56B2D
gene id: 9615:OR56B2D
uniprot id: A0A8P0NSB7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MFSD14B
gene id: 9615:MFSD14B
uniprot id: A0A8C0LTI5
uniprot id: A0A8I3MA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9615:RNF20
gene id: 9615:RNF20
uniprot id: A0A8C0QN41
uniprot id: A0A8I3N6U1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9615:HSD17B12
gene id: 9615:HSD17B12
uniprot id: A0A8C0MDV5
uniprot id: A0A8I3NX04
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:HSPA2
gene id: 9615:HSPA2
uniprot id: A0A8C0QLN2
uniprot id: A0A8I3N1B1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9615:GPN2
gene id: 9615:GPN2
uniprot id: A0A8C0N3I9
uniprot id: A0A8I3NED3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9615:GJB4
gene id: 9615:GJB4
uniprot id: A0A8C0NMW0
uniprot id: A0A8I3P1D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:TTC21B
gene id: 9615:TTC21B
uniprot id: A0A8C0TNR8
uniprot id: A0A8I3NWC8
names: Similarity
messages: Belongs to the TTC21 family.

9615:FAM32A
gene id: 9615:FAM32A
uniprot id: A0A8C0RR58
uniprot id: A0A8I3QXR1
names: Similarity
messages: Belongs to the FAM32 family.

9615:SLC25A28
gene id: 9615:SLC25A28
uniprot id: A0A8C0TZR9
uniprot id: A0A8I3Q7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:MINDY4
gene id: 9615:MINDY4
uniprot id: A0A8C0QA69
uniprot id: A0A8P0THH7
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9615:EFNB2
gene id: 9615:EFNB2
uniprot id: A0A8C0M8W9
uniprot id: B0LDS6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:POLR2I
gene id: 9615:POLR2I
uniprot id: A0A8C0T1X8
uniprot id: A0A8I3MHP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9615:AGPAT1
gene id: 9615:AGPAT1
uniprot id: A0A8I3NV03
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9615:EBF2
gene id: 9615:EBF2
uniprot id: A0A8C0P653
uniprot id: A0A8I3P166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9615:CORO6
gene id: 9615:CORO6
uniprot id: A0A8C0MW41
uniprot id: A0A8C0PRT4
uniprot id: A0A8I3NA57
uniprot id: A0A8I3NG92
uniprot id: A0A8I3RWP3
names: Similarity
messages: Belongs to the WD repeat coronin family.

9615:CDIP1
gene id: 9615:CDIP1
uniprot id: A0A8C0YY01
uniprot id: A0A8I3MIL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9615:ELAPOR1
gene id: 9615:ELAPOR1
uniprot id: A0A8I3RR87
uniprot id: A0A8P0SPV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9615:CCDC181
gene id: 9615:CCDC181
uniprot id: A0A8C0PDX5
uniprot id: A0A8I3MT62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

9615:EPOR
gene id: 9615:EPOR
uniprot id: Q2KL21
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
messages: Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein APS, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3 and CRKL. The N-terminal SH2 domain of PTPN6 binds Tyr-454 and inhibits signaling through dephosphorylation of JAK2. APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11. Binding of JAK2 (through its N-terminal) promotes cell-surface expression. Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L and INPP5D/SHIP1 (By similarity).
messages: Membrane
messages: On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-454 is required for PTPN6 interaction, Tyr-426 for PTPN11. Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site (By similarity).
messages: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated. Ubiquitination mediates proliferation and survival of EPO-dependent cells. Ubiquitination at Lys-281 mediates receptor internalization, whereas ubiquitination at Lys-453 promotes trafficking of activated receptors to the lysosomes for degradation (By similarity).

9615:CAPZA1
gene id: 9615:CAPZA1
uniprot id: A0A8C0SIZ0
uniprot id: A0A8I3NF50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9615:HADHB
gene id: 9615:HADHB
uniprot id: A0A8C0QIR3
uniprot id: A0A8P0P352
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9615:DDX5
gene id: 9615:DDX5
uniprot id: A0A8C0RLH5
uniprot id: A0A8I3PSN4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9615:UFC1
gene id: 9615:UFC1
uniprot id: A0A8C0P6D8
uniprot id: A0A8I3Q438
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9615:FUT7
gene id: 9615:FUT7
uniprot id: Q659L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9615:DPCD
gene id: 9615:DPCD
uniprot id: A0A8C0NL61
uniprot id: A0A8I3PDQ5
names: Similarity
messages: Belongs to the DPCD family.

9615:USP14
gene id: 9615:USP14
uniprot id: A0A8C0PNC3
uniprot id: A0A8C0PSM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9615:RPS5
gene id: 9615:RPS5
uniprot id: A0A8C0LSD9
uniprot id: A0A8I3MC30
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9615:GPBP1L1
gene id: 9615:GPBP1L1
uniprot id: A0A8C0NTK8
uniprot id: A0A8I3PDE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9615:UBE2R2
gene id: 9615:UBE2R2
uniprot id: A0A8C0MHX1
uniprot id: A0A8I3PHW5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:ZYG11B
gene id: 9615:ZYG11B
uniprot id: A0A8I3S069
names: Similarity
messages: Belongs to the zyg-11 family.

9615:DYNC1I2
gene id: 9615:DYNC1I2
uniprot id: A0A8C0TWM4
uniprot id: A0A8I3PUW6
uniprot id: A0A8I3PY97
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9615:SLCO3A1
gene id: 9615:SLCO3A1
uniprot id: A0A8C0M7K8
uniprot id: A0A8P0SFX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9615:FYTTD1
gene id: 9615:FYTTD1
uniprot id: A0A8C0NUT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

9615:MKNK1
gene id: 9615:MKNK1
uniprot id: A0A8C0NXI9
uniprot id: A0A8I3PD30
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:FBP2
gene id: 9615:FBP2
uniprot id: A0A8C0ME46
names: Similarity
messages: Belongs to the FBPase class 1 family.

9615:AKAP12
gene id: 9615:AKAP12
uniprot id: A0A8C0STI4
uniprot id: A0A8C0STP0
uniprot id: A0A8C0SUQ5
uniprot id: A0A8P0N3R0
names: Subcellular Location Annotation
messages: Membrane

9615:SUCLG1
gene id: 9615:SUCLG1
uniprot id: A0A8C0N6R2
uniprot id: A0A8I3NS98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9615:FGD4
gene id: 9615:FGD4
uniprot id: A0A8C0PFI1
uniprot id: A0A8C0PKE0
uniprot id: A0A8I3P5I6
uniprot id: A0A8I3S2R6
names: Subcellular Location Annotation
messages: cytoskeleton

9615:LRRC8E
gene id: 9615:LRRC8E
uniprot id: A0A8C0T6L4
uniprot id: A0A8P0NJJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9615:NADK2
gene id: 9615:NADK2
uniprot id: A0A8C0M2N5
uniprot id: A0A8C0RAD2
uniprot id: A0A8I3MUL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

9615:MRPL4
gene id: 9615:MRPL4
uniprot id: A0A8C0TFP8
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9615:OR5L1C
gene id: 9615:OR5L1C
uniprot id: A0A8C0MBP5
uniprot id: A0A8I3N7U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CXCL8
gene id: 9615:CXCL8
uniprot id: P41324
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
messages: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
messages: Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.
messages: Secreted

9615:BCCIP
gene id: 9615:BCCIP
uniprot id: A0A8C0TG88
uniprot id: A0A8I3Q0V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

9615:PEPD
gene id: 9615:PEPD
uniprot id: A0A8P0N9S8
names: Similarity
messages: Belongs to the peptidase M24B family.

9615:PPP1R9B
gene id: 9615:PPP1R9B
uniprot id: A0A8P0PE40
names: Subcellular Location Annotation
messages: cytoskeleton

9615:MAPK1IP1L
gene id: 9615:MAPK1IP1L
uniprot id: A0A8C0PQ41
uniprot id: A0A8I3NW87
names: Similarity
messages: Belongs to the MISS family.

9615:COX11
gene id: 9615:COX11
uniprot id: A0A8C0RIZ0
uniprot id: A0A8I3NUH7
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9615:IGF1
gene id: 9615:IGF1
uniprot id: P33712
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.
messages: Secreted
messages: The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. A major quantitative trait locus (QTL) on chromosome 15 influences size variation within a single breed. In particular, a single-nucleotide polymorphism haplotype in IGF1 (synonymous SNP in exon 3) is common to all small breeds (less than 9 kg) and nearly absent from giant breeds (more than 30 kg), suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).

9615:HAT1
gene id: 9615:HAT1
uniprot id: A0A8C0S1A3
uniprot id: A0A8I3S6P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9615:ATP5MG
gene id: 9615:ATP5MG
uniprot id: A0A8C0RV29
uniprot id: A0A8I3MMN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9615:KLHL3
gene id: 9615:KLHL3
uniprot id: A0A8C0SB19
uniprot id: A0A8C0SB64
uniprot id: A0A8I3NXP4
uniprot id: A0A8I3S257
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

9615:PDE10A
gene id: 9615:PDE10A
uniprot id: A0A8C0MYK1
uniprot id: A0A8P0SVC7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:RPS27A
gene id: 9615:RPS27A
uniprot id: A0A8C0T835
uniprot id: A0A8I3NFB9
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9615:LSM3
gene id: 9615:LSM3
uniprot id: A0A8C0SY27
uniprot id: A0A8I3PR17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9615:SVOP
gene id: 9615:SVOP
uniprot id: A0A8C0TI85
uniprot id: A0A8P0ND34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9615:ATAD1
gene id: 9615:ATAD1
uniprot id: A0A8C0TRI3
names: Similarity
messages: Belongs to the AAA ATPase family.

9615:OXTR
gene id: 9615:OXTR
uniprot id: A0A5K1UVD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9615:LECT2
gene id: 9615:LECT2
uniprot id: A0A8C0MK24
uniprot id: A0A8I3NVV2
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9615:ETV1
gene id: 9615:ETV1
uniprot id: A0A8C0T546
uniprot id: A0A8C0Z286
uniprot id: A0A8I3PR30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:MDH1
gene id: 9615:MDH1
uniprot id: A0A8C0Q1T7
uniprot id: A0A8I3P5G6
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9615:GABRD
gene id: 9615:GABRD
uniprot id: A0A8C0RA95
uniprot id: A0A8I3P3X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:HTT
gene id: 9615:HTT
uniprot id: A0A8C0Q3X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

9615:OR6X1
gene id: 9615:OR6X1
uniprot id: G3FJE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:LY6G5C
gene id: 9615:LY6G5C
uniprot id: Q9XSV5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundantly expressed in the epididymis.
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: N-glycosylated.
messages: Secreted

9615:EZR
gene id: 9615:EZR
uniprot id: A0A8C0NAG2
uniprot id: A0A8I3MKE1
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9615:RPL21
gene id: 9615:RPL21
uniprot id: A0A8C0SAV2
uniprot id: F1PWM2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9615:RPS19BP1
gene id: 9615:RPS19BP1
uniprot id: A0A8C0NSC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

9615:IL16
gene id: 9615:IL16
uniprot id: A0A8P0NFS4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

9615:LMBR1L
gene id: 9615:LMBR1L
uniprot id: A0A8C0TTC8
uniprot id: A0A8I3P7U0
names: Similarity
messages: Belongs to the LIMR family.

9615:SPARC
gene id: 9615:SPARC
uniprot id: A0A8C0QBH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

9615:KCNAB2
gene id: 9615:KCNAB2
uniprot id: J9P0G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: synaptosome

9615:SLC24A4
gene id: 9615:SLC24A4
uniprot id: A0A8C0LT58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9615:FBXO46
gene id: 9615:FBXO46
uniprot id: A0A8C0M445
uniprot id: A0A8I3MXV3
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9615:SUGP2
gene id: 9615:SUGP2
uniprot id: A0A8I3S0S2
uniprot id: A0A8P0SIW8
names: Subcellular Location Annotation
messages: Nucleus

9615:PIWIL2
gene id: 9615:PIWIL2
uniprot id: A0A8C0TKH6
uniprot id: A0A8I3PR35
names: Similarity
messages: Belongs to the argonaute family.

9615:RNF13
gene id: 9615:RNF13
uniprot id: A0A8C0S8I5
uniprot id: A0A8I3S8K2
names: Subcellular Location Annotation
messages: Membrane

9615:PIGO
gene id: 9615:PIGO
uniprot id: A0A8C0RKX1
uniprot id: A0A8I3MQG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:TMEM183A
gene id: 9615:TMEM183A
uniprot id: A0A8C0M0Y1
uniprot id: A0A8I3RY51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

9615:FAM53B
gene id: 9615:FAM53B
uniprot id: A0A8C0TAC6
uniprot id: A0A8I3PQG5
names: Similarity
messages: Belongs to the FAM53 family.

9615:EIF5
gene id: 9615:EIF5
uniprot id: A0A8C0S803
uniprot id: A0A8I3S343
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

9615:LOC479600
gene id: 9615:LOC479600
uniprot id: A0A8C0MFE0
uniprot id: A0A8C0MIZ7
uniprot id: A0A8C0MM34
uniprot id: A0A8C0MP39
uniprot id: A0A8C0SRZ3
uniprot id: A0A8I3PZ80
uniprot id: A0A8I3Q5E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTNNBIP1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9615:NAP1L1
gene id: 9615:NAP1L1
uniprot id: A0A8C0MDE3
uniprot id: A0A8I3N2W1
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9615:FHL5
gene id: 9615:FHL5
uniprot id: A0A8C0MDM9
uniprot id: A0A8I3N9H8
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9615:SLC25A17
gene id: 9615:SLC25A17
uniprot id: A0A8C0P0Q9
uniprot id: A0A8I3P4S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:GAS8
gene id: 9615:GAS8
uniprot id: A0A8C0TF27
uniprot id: A0A8P0SW57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum axoneme

9615:GDF3
gene id: 9615:GDF3
uniprot id: A0A8I3Q963
names: Similarity
messages: Belongs to the TGF-beta family.

9615:LOC607552
gene id: 9615:LOC607552
uniprot id: A0A8C0NXP9
names: Subcellular Location Annotation
messages: Membrane

9615:HDAC7
gene id: 9615:HDAC7
uniprot id: A0A8P0P3P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9615:CAV3
gene id: 9615:CAV3
uniprot id: A0A8C0TW67
uniprot id: A0A8I3NGG6
uniprot id: Q3HTT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola
messages: sarcolemma

9615:C1QA
gene id: 9615:C1QA
uniprot id: A0A8C0M2W5
uniprot id: A0A8I3MKD7
names: Function
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

9615:CDC45
gene id: 9615:CDC45
uniprot id: A0A8C0NXS2
uniprot id: A0A8I3Q3M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9615:CPT1A
gene id: 9615:CPT1A
uniprot id: A0A8C0S023
uniprot id: A0A8I3N3L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:PFKFB4
gene id: 9615:PFKFB4
uniprot id: A0A8C0TK93
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9615:HYAL2
gene id: 9615:HYAL2
uniprot id: A0A8I3P9L7
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9615:DAZL
gene id: 9615:DAZL
uniprot id: A0A8C0PAJ4
uniprot id: A0A8P0NNN3
names: Subcellular Location Annotation
messages: Cytoplasm

9615:NOG
gene id: 9615:NOG
uniprot id: E2RVU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9615:CLDN1
gene id: 9615:CLDN1
uniprot id: A0A8C0T9W5
uniprot id: A0A8I3PHM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:PRKD3
gene id: 9615:PRKD3
uniprot id: A0A8C0RD54
uniprot id: A0A8I3NYB8
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9615:SLC31A2
gene id: 9615:SLC31A2
uniprot id: A0A8C0SSG2
uniprot id: A0A8P0TKN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9615:MMP14
gene id: 9615:MMP14
uniprot id: A0A8C0NSG8
uniprot id: A0A8I3MND9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Cytoplasm
messages: Melanosome

9615:CSNK1G3
gene id: 9615:CSNK1G3
uniprot id: A0A8C0PIH9
uniprot id: A0A8C0Q7S6
uniprot id: A0A8I3N7M4
uniprot id: A0A8P0NWJ8
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9615:KCNJ15
gene id: 9615:KCNJ15
uniprot id: A0A8I3S6Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9615:BRD1
gene id: 9615:BRD1
uniprot id: A0A8C0T538
uniprot id: A0A8I3MXH0
names: Subcellular Location Annotation
messages: Nucleus

9615:SUPT20H
gene id: 9615:SUPT20H
uniprot id: A0A8C0NIZ6
uniprot id: A0A8I3Q2F4
names: Similarity
messages: Belongs to the SPT20 family.

9615:LOC100688081
gene id: 9615:LOC100688081
uniprot id: P86218
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
messages: Specific component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:15835887). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:15835887, PubMed:29519914). Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex (By similarity).

9615:KIF20B
gene id: 9615:KIF20B
uniprot id: A0A8C0TZS9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:SLC25A37
gene id: 9615:SLC25A37
uniprot id: A0A8C0PE01
uniprot id: A0A8I3P7L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:ARSI
gene id: 9615:ARSI
uniprot id: A0A8C0S4K7
uniprot id: A0A8I3N2H8
uniprot id: Q32KH7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts.
messages: Endoplasmic reticulum
messages: Secreted
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
messages: The oxidation of Cys-94 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying factor 1, seems critical for catalytic activity.

9615:CLCN2
gene id: 9615:CLCN2
uniprot id: A0A8C0RGC4
uniprot id: A0A8I3Q0B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

9615:PPIP5K1
gene id: 9615:PPIP5K1
uniprot id: A0A8C0T3G8
uniprot id: A0A8I3PM37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9615:CSF2
gene id: 9615:CSF2
uniprot id: P48749
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).
messages: Secreted

9615:OR4P6
gene id: 9615:OR4P6
uniprot id: A0A8C0SHX6
uniprot id: A0A8I3RTZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:DUOX1
gene id: 9615:DUOX1
uniprot id: Q9MZF4
names: Activity Regulation
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: By forskolin (at protein level). By thyrotropin.
messages: Expressed in thyrocytes (at protein level). Specifically expressed in thyroid.
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Interacts with TPO and CYBA (By similarity). Interacts with TXNDC11.
messages: N-glycosylated.
messages: Peroxidase activity is inhibited by aminobenzohydrazide (By similarity). The NADPH oxidase activity is calcium-dependent.

9615:NIPBL
gene id: 9615:NIPBL
uniprot id: A0A8C0RAG9
uniprot id: A0A8I3RRT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9615:NCF2
gene id: 9615:NCF2
uniprot id: A7E3N1
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9615:OR10V5
gene id: 9615:OR10V5
uniprot id: A0A8P0SQM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CLDN3
gene id: 9615:CLDN3
uniprot id: Q95KM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
messages: Cell membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:SATB2
gene id: 9615:SATB2
uniprot id: A0A8C0TGP6
uniprot id: A0A8I3PYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9615:MYCBP
gene id: 9615:MYCBP
uniprot id: A0A8C0Q3B3
uniprot id: J9P9G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

9615:WDR55
gene id: 9615:WDR55
uniprot id: A0A8C0Q5M2
uniprot id: A0A8I3RRX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9615:RFLNB
gene id: 9615:RFLNB
uniprot id: A0A8C0RLD5
uniprot id: A0A8I3NLU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9615:LOC478413
gene id: 9615:LOC478413
uniprot id: A0A8I3SB74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

9615:AQP1
gene id: 9615:AQP1
uniprot id: Q9N2J4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
messages: Homotetramer (By similarity). Interacts with EPHB2; involved in endolymph production in the inner ear. Identified in a complex with STOM (By similarity).
messages: Pharmacologically inhibited by submillimolar concentrations of mercury.

9615:LOC484492
gene id: 9615:LOC484492
uniprot id: A0A8C0S3F2
uniprot id: A0A8I3MK53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:MOGS
gene id: 9615:MOGS
uniprot id: A0A8C0NZ98
uniprot id: A0A8P0NAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9615:AIMP2
gene id: 9615:AIMP2
uniprot id: A0A8C0NVS1
uniprot id: A0A8I3NEL4
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9615:TFAP2B
gene id: 9615:TFAP2B
uniprot id: Q76HI7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AP-2 family.
messages: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity (By similarity).
messages: Nucleus
messages: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia (By similarity).
messages: Sumoylated on Lys-21; which inhibits transcriptional activity.

9615:CLCA1
gene id: 9615:CLCA1
uniprot id: A0A8C0NNS9
uniprot id: A0A8I3P659
names: Similarity
messages: Belongs to the CLCR family.

9615:GDPD5
gene id: 9615:GDPD5
uniprot id: A0A8C0NR65
uniprot id: A0A8C0NUU6
uniprot id: A0A8P0PBU4
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9615:GPC2
gene id: 9615:GPC2
uniprot id: A0A8I3RS61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9615:SLC35B2
gene id: 9615:SLC35B2
uniprot id: A0A8C0SAC1
uniprot id: B2BMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9615:ERC1
gene id: 9615:ERC1
uniprot id: A0A8C0TU27
uniprot id: A0A8C0TVS2
uniprot id: A0A8C0Z783
uniprot id: A0A8I3PZD0
uniprot id: A0A8I3Q2L0
uniprot id: A0A8I3Q6V2
names: Subcellular Location Annotation
messages: Cytoplasm

9615:XPC
gene id: 9615:XPC
uniprot id: A0A8C0SX48
uniprot id: A0A8I3PYW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

9615:GDAP1
gene id: 9615:GDAP1
uniprot id: A0A8C0RJB7
uniprot id: A0A8I3Q2T8
names: Similarity
messages: Belongs to the GST superfamily.

9615:APH1A
gene id: 9615:APH1A
uniprot id: A0A5F4DBV7
uniprot id: A0A8C0MA93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9615:SARDH
gene id: 9615:SARDH
uniprot id: A0A8C0LWN2
uniprot id: A0A8I3NBY7
names: Similarity
messages: Belongs to the GcvT family.

9615:TMPO
gene id: 9615:TMPO
uniprot id: A0A8C0NW71
uniprot id: A0A8C0NXK9
uniprot id: A0A8C0P293
uniprot id: A0A8C0PBQ8
uniprot id: A0A8C0RPP2
uniprot id: A0A8I3PQ05
uniprot id: A0A8I3PQM7
uniprot id: A0A8I3PYT6
uniprot id: A0A8I3PZV2
uniprot id: A0A8I3S615
names: Similarity
messages: Belongs to the LEM family.

9615:MED15
gene id: 9615:MED15
uniprot id: A0A8I3PI14
uniprot id: A0A8I3PQB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:CLDN34
gene id: 9615:CLDN34
uniprot id: A0A8C0RG35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9615:HDHD2
gene id: 9615:HDHD2
uniprot id: A0A8C0NR62
uniprot id: A0A8P0SLS9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9615:MCM4
gene id: 9615:MCM4
uniprot id: A0A8C0P8X4
uniprot id: A0A8I3PWX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9615:PTPRA
gene id: 9615:PTPRA
uniprot id: A0A8C0SUK5
uniprot id: A0A8C0SUQ3
uniprot id: A0A8I3NMU5
uniprot id: A0A8I3RYW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9615:WNT1
gene id: 9615:WNT1
uniprot id: A0A8I3PGI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:EIF2B1
gene id: 9615:EIF2B1
uniprot id: A0A8C0Z5H2
uniprot id: A0A8I3P3X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9615:C1H9orf64
gene id: 9615:C1H9orf64
uniprot id: A0A8C0RV40
uniprot id: A0A8I3MYG7
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

9615:AQP9
gene id: 9615:AQP9
uniprot id: A0A8C0NBN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9615:OS9
gene id: 9615:OS9
uniprot id: A0A8C0MI89
uniprot id: A0A8C0RDR8
uniprot id: A0A8I3NEI4
uniprot id: A0A8I3NKE8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9615:LOC119864504
gene id: 9615:LOC119864504
uniprot id: A0A8C0MKT1
uniprot id: A0A8I3NGD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9615:CFAP53
gene id: 9615:CFAP53
uniprot id: A0A8C0SD35
uniprot id: A0A8P0SN28
names: Similarity
messages: Belongs to the CFAP53 family.

9615:TRAPPC6B
gene id: 9615:TRAPPC6B
uniprot id: A0A8C0M3V3
uniprot id: A0A8I3N5C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9615:LTBR
gene id: 9615:LTBR
uniprot id: A0A8C0PHW1
uniprot id: A0A8P0SVV0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:NEXMIF
gene id: 9615:NEXMIF
uniprot id: A0A8C0MZQ2
uniprot id: A0A8I3Q8D0
names: Subcellular Location Annotation
messages: Nucleus

9615:PKHD1
gene id: 9615:PKHD1
uniprot id: E2RK30
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Interacts with CAMLG. Interacts with PKD2. Interacts (via CST) with ARF4; this interaction allows an efficient PKHD1 trafficking to the cilium. Interacts (via CST) with RAB8A; this interaction controls trafficking through the endomembrane systeme and to the cilium. Interacts (via CST) with TULP3; this interaction allows PKHD1 trafficking to the cilium.
messages: N-glycosylated.
messages: Nucleus
messages: Palmitoylated. Palmitoylation facilitates the trafficking to the cilia and membrane targeting.
messages: Promotes ciliogenesis in renal epithelial cells and therefore participates in the tubules formation and/ or ensures the maintenance of the architecture of the lumen of the kidney (By similarity). Has an impact on cellular symmetry by ensuring correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly and by maintaining oriented cell division (OCD) during tubular elongation through planar cell polarity (PCP) pathway (By similarity). During epithelial cell morphogenesis regulates also cell-cell and cell-matrix adhesion and participates in cell motility (PubMed:32698519, PubMed:31398719). Promotes cell-cell contact through the positive regulation of PTK2 kinase activity leading to either positive regulation of epithelial cell proliferation through the HRAS/RAF1 pathways, or negative regulation of apoptosis through the PDK1/AKT1 pathway (By similarity). May act in collecting-duct and biliary differentiation (By similarity). May participate in the regulation of the cholangiocytes proliferation and the CCN2 production in an CXCL8-dependent manner (By similarity).
messages: Secreted
messages: Several proteolytic cleavages occur within the extracellular domain, whereas at least one cleavage occurs within the cytoplasmic domain. Cleaved by a probable proprotein convertase which produces an extracellular domain (polyductin extracellular domain, (PECD)) and a C-terminal fragment (polyductin transmembrane fragment (PTM)) which are tethered together by disulfide bonds. This extracellular domain (PECD) is then shed from the primary cilium by activation of a member of the ADAM metalloproteinase disintegrins family, resulting in concomitant release of an intra-cellular C-terminal fragment (ICD) via a gamma-secretase-dependent process. The proteolytic cleavage of the C-terminal intracellular fragment (ICD) is controlled by cytosolic calcium concentration and activation of PKC.
messages: centromere
messages: cilium
messages: cilium basal body
messages: extracellular exosome
messages: spindle

9615:ADAM12
gene id: 9615:ADAM12
uniprot id: A0A8I3PTF2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:GABRG2
gene id: 9615:GABRG2
uniprot id: A0A8C0NGN4
uniprot id: A0A8C0PV63
uniprot id: A0A8I3MDZ2
uniprot id: E2RSQ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:CREBBP
gene id: 9615:CREBBP
uniprot id: A0A8C0SS06
uniprot id: A0A8P0NNM4
names: Subcellular Location Annotation
messages: Cytoplasm

9615:YPEL5
gene id: 9615:YPEL5
uniprot id: A0A8C0YV52
uniprot id: A0A8I3RYQ6
names: Similarity
messages: Belongs to the yippee family.

9615:KPNA4
gene id: 9615:KPNA4
uniprot id: A0A8C0RKC2
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9615:OR2F1
gene id: 9615:OR2F1
uniprot id: Q95156
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Putative odorant or sperm cell receptor.

9615:CD70
gene id: 9615:CD70
uniprot id: A0A8C0NZL5
uniprot id: A0A8I3NFC1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9615:HPRT1
gene id: 9615:HPRT1
uniprot id: A0A8C0MLZ6
uniprot id: A0A8I3PNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9615:KIF3B
gene id: 9615:KIF3B
uniprot id: A0A8C0NC53
uniprot id: A0A8I3P6F1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:CDCA8
gene id: 9615:CDCA8
uniprot id: A0A8C0QD51
uniprot id: A0A8I3QB13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9615:SEC11C
gene id: 9615:SEC11C
uniprot id: P13679
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473, PubMed:8444896, PubMed:14559916). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
messages: Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SPCS2 and SPCS3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: May undergo processing at the N-terminus.
messages: The C-terminal short (CTS) helix is essential for catalytic activity (By similarity). It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates (By similarity).

9615:CALY
gene id: 9615:CALY
uniprot id: A0A8P0PC11
names: Similarity
messages: Belongs to the NSG family.

9615:GIMAP4
gene id: 9615:GIMAP4
uniprot id: A0A8C0PIK7
uniprot id: A0A8I3NE68
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9615:RIDA
gene id: 9615:RIDA
uniprot id: A0A8C0SGZ7
uniprot id: A0A8I3PQP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9615:HNF4A
gene id: 9615:HNF4A
uniprot id: A0A8C0N5R1
uniprot id: A0A8I3NQX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:VWA1
gene id: 9615:VWA1
uniprot id: A0A8C0Q2Y6
uniprot id: A0A8I3PTU8
names: Subcellular Location Annotation
messages: Membrane
messages: basement membrane

9615:KRT222
gene id: 9615:KRT222
uniprot id: A0A8C0RLG6
uniprot id: A0A8P0SR35
names: Similarity
messages: Belongs to the intermediate filament family.

9615:LOC119863920
gene id: 9615:LOC119863920
uniprot id: A0A8C0P4Q8
uniprot id: A0A8I3MM72
names: Subcellular Location Annotation
messages: Nucleus

9615:OR6S1
gene id: 9615:OR6S1
uniprot id: A0A8C0S9J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MAF1
gene id: 9615:MAF1
uniprot id: A0A8I3NJ58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

9615:OR4S7
gene id: 9615:OR4S7
uniprot id: A0A8C0RD89
uniprot id: A0A8P0SDD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:METTL11B
gene id: 9615:METTL11B
uniprot id: A0A8C0PPR0
uniprot id: A0A8I3RRP4
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9615:DLA-DRA
gene id: 9615:DLA-DRA
uniprot id: A0A8C0RKX0
uniprot id: Q30437
names: Similarity
messages: Belongs to the MHC class II family.

9615:DYNLRB1
gene id: 9615:DYNLRB1
uniprot id: A0A8C0QBF7
uniprot id: A0A8I3NZF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9615:CLCN5
gene id: 9615:CLCN5
uniprot id: A0A8I3PXT2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:MYO1C
gene id: 9615:MYO1C
uniprot id: A0A8C0PUG5
uniprot id: A0A8C0PUL5
uniprot id: A0A8I3NVP7
uniprot id: A0A8P0PEW8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9615:SPCS1
gene id: 9615:SPCS1
uniprot id: A0A8C0M9Q2
uniprot id: P83362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SPCS1 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:3511473). Dispensable for SPC enzymatic activity (By similarity).
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:3511473). Within the complex, interacts with SPCS2 and SPCS3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expressed in the pancreas (at protein level).
messages: May be phosphorylated.
messages: Membrane

9615:ECHDC1
gene id: 9615:ECHDC1
uniprot id: A0A8C0MQA0
uniprot id: A0A8I3MVU4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9615:POR
gene id: 9615:POR
uniprot id: D5LG84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9615:BARX2
gene id: 9615:BARX2
uniprot id: A0A8P0SF37
names: Subcellular Location Annotation
messages: Nucleus

9615:RRAGA
gene id: 9615:RRAGA
uniprot id: A0A8C0T7N8
uniprot id: A0A8I3NIS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9615:PPARGC1A
gene id: 9615:PPARGC1A
uniprot id: A0A8C0M294
uniprot id: A0A8C0M3T2
uniprot id: A0A8I3RUL9
names: Subcellular Location Annotation
messages: PML body

9615:RC3H2
gene id: 9615:RC3H2
uniprot id: A0A8C0Q0W9
uniprot id: A0A8I3NF19
names: Subcellular Location Annotation
messages: P-body

9615:NAV3
gene id: 9615:NAV3
uniprot id: A0A8P0SBA4
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9615:KAT5
gene id: 9615:KAT5
uniprot id: A0A8C0NLP0
uniprot id: A0A8C0RJW0
uniprot id: A0A8C0YZX3
uniprot id: A0A8I3PEI4
uniprot id: A0A8I3S3L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9615:NUBPL
gene id: 9615:NUBPL
uniprot id: A0A8C0SJ71
uniprot id: A0A8C0SK30
uniprot id: A0A8C0SKW3
uniprot id: A0A8I3NK60
uniprot id: A0A8P0TAY3
uniprot id: A0A8P0TFH3
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9615:FBP1
gene id: 9615:FBP1
uniprot id: A0A8C0QC07
uniprot id: A0A8I3MZ42
names: Similarity
messages: Belongs to the FBPase class 1 family.

9615:DHCR7
gene id: 9615:DHCR7
uniprot id: A0A8C0PLQ7
uniprot id: A0A8P0NCH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9615:S100A16
gene id: 9615:S100A16
uniprot id: A0A8C0NZ47
uniprot id: A0A8I3MRE6
names: Similarity
messages: Belongs to the S-100 family.

9615:ADGRF3
gene id: 9615:ADGRF3
uniprot id: A0A8C0QC80
names: Subcellular Location Annotation
messages: Membrane

9615:NR3C1
gene id: 9615:NR3C1
uniprot id: A0A0A7KLD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

9615:MPV17L2
gene id: 9615:MPV17L2
uniprot id: A0A8I3PV69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9615:HTRA2
gene id: 9615:HTRA2
uniprot id: A0A8C0RNJ0
uniprot id: Q45FF7
names: Similarity
messages: Belongs to the peptidase S1C family.

9615:BAAT
gene id: 9615:BAAT
uniprot id: A0A8C0RZV4
uniprot id: A0A8I3N1E1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9615:WNT10B
gene id: 9615:WNT10B
uniprot id: A0A8C0P6D0
uniprot id: A0A8I3PFR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9615:PEX1
gene id: 9615:PEX1
uniprot id: A0A8P0SQD3
uniprot id: A0A8P0TFP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9615:ASIC5
gene id: 9615:ASIC5
uniprot id: A0A8I3RW06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9615:GPRC5A
gene id: 9615:GPRC5A
uniprot id: A0A8C0RLU4
uniprot id: A0A8I3PWR7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:NR2E1
gene id: 9615:NR2E1
uniprot id: A0A8C0YU02
uniprot id: A0A8I3RWG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:ENPP4
gene id: 9615:ENPP4
uniprot id: A0A8C0MKF3
uniprot id: A0A8I3NY55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

9615:NDUFS1
gene id: 9615:NDUFS1
uniprot id: A0A8C0MRI7
uniprot id: A0A8I3S1V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

9615:ESRRA
gene id: 9615:ESRRA
uniprot id: Q6QMY5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transcriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation. Interacts with MAPK15; promotes re-localization of ESRRA to the cytoplasm through a XPO1-dependent mechanism then inhibits ESRRA transcriptional activity.
messages: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. May function as a modulator of the estrogen signaling pathway in the uterus. Induces the expression of PERM1 in the skeletal muscle (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
messages: Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding (By similarity).
messages: Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding (By similarity).

9615:QPCTL
gene id: 9615:QPCTL
uniprot id: A0A8C0MB86
uniprot id: A0A8I3MXW9
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9615:GORAB
gene id: 9615:GORAB
uniprot id: A0A8P0NGN5
names: Similarity
messages: Belongs to the GORAB family.

9615:COPS3
gene id: 9615:COPS3
uniprot id: A0A8C0M0T8
uniprot id: A0A8I3PRS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN3 family.
messages: Cytoplasm
messages: Nucleus

9615:KLRD1
gene id: 9615:KLRD1
uniprot id: Q38HS3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Can form disulfide-bonded heterodimer with NKG2 family members KLRC1 and KLRC2. KLRD1-KLRC1 heterodimer interacts with peptide-bound MHC-E-B2M heterotrimeric complex. KLRD1 plays a prominent role in directly interacting with MHC-E. KLRD1-KLRC1 interacts with much higher affinity with peptide-bound MHC-E-B2M than KLRD1-KLRC2. Interacts with the adapter protein TYROBP/DAP12; this interaction is required for cell surface expression and cell activation.
messages: Cell membrane
messages: Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal.
messages: KLRD1-KLRC1 acts as an immune inhibitory receptor. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Upon MHC-E-peptide binding, transmits intracellular signals through KLRC1 immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules.
messages: KLRD1-KLRC2 acts as an immune activating receptor. On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.

9615:VPS18
gene id: 9615:VPS18
uniprot id: A0A8C0P7C4
uniprot id: A0A8I3Q5H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9615:CUEDC2
gene id: 9615:CUEDC2
uniprot id: A0A8C0PD51
uniprot id: A0A8I3PW03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9615:CYP8B1
gene id: 9615:CYP8B1
uniprot id: A0A8C0NR21
uniprot id: A0A8P0N817
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9615:PPP2R5D
gene id: 9615:PPP2R5D
uniprot id: A0A8C0NEW7
uniprot id: A0A8I3MU82
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9615:TRMT112
gene id: 9615:TRMT112
uniprot id: A0A8C0N7M9
uniprot id: A0A8I3QY97
names: Similarity
messages: Belongs to the TRM112 family.

9615:EIF6
gene id: 9615:EIF6
uniprot id: A0A8C0RR17
uniprot id: A0A8I3P3Q0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9615:HMGB2
gene id: 9615:HMGB2
uniprot id: A0A8C0TCZ5
uniprot id: A0A8I3P9Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9615:CYP2R1
gene id: 9615:CYP2R1
uniprot id: A0A8C0TD49
uniprot id: A0A8I3PQT3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:FZD3
gene id: 9615:FZD3
uniprot id: A0A8C0Z036
uniprot id: A0A8I3PFW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:CNGA1
gene id: 9615:CNGA1
uniprot id: Q28279
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.
messages: Cell membrane
messages: Forms a heterotetramer with CNGB1 in a 3:1 ratio. May also form cyclic nucleotide-activated homotetrameric channels, that are efficiently activated by saturating cGMP, but poorly activated by saturating cAMP compared to the heterotetramer with CNGB1.
messages: Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
messages: The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits.

9615:GCHFR
gene id: 9615:GCHFR
uniprot id: A0A8C0TX72
uniprot id: A0A8I3PYY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9615:KCNMB1
gene id: 9615:KCNMB1
uniprot id: Q28266
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer (By similarity).
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity).

9615:LOC100688084
gene id: 9615:LOC100688084
uniprot id: P81255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
messages: Secreted

9615:PARG
gene id: 9615:PARG
uniprot id: A0A8C0P983
uniprot id: A0A8I3S6T0
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9615:IL7
gene id: 9615:IL7
uniprot id: A0A8C0N6M5
uniprot id: Q0MUT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Secreted

9615:NDUFAF4
gene id: 9615:NDUFAF4
uniprot id: A0A8C0MRB2
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9615:LYPLAL1
gene id: 9615:LYPLAL1
uniprot id: A0A8C0P625
uniprot id: A0A8P0NCT4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9615:MAPK8
gene id: 9615:MAPK8
uniprot id: A0A8C0NSG4
uniprot id: A0A8C0NVS4
uniprot id: A0A8C0T9H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9615:GTF2B
gene id: 9615:GTF2B
uniprot id: A0A8C0NUF2
uniprot id: A0A8I3P1A2
names: Similarity
messages: Belongs to the TFIIB family.

9615:CCR1
gene id: 9615:CCR1
uniprot id: A0A8C0PWA0
uniprot id: A0A8I3RZ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9615:DVL1
gene id: 9615:DVL1
uniprot id: A0A8C0Q2G1
uniprot id: A0A8P0SMX2
names: Similarity
messages: Belongs to the DSH family.

9615:GALT
gene id: 9615:GALT
uniprot id: A0A8C0MBX6
uniprot id: A0A8I3PT77
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9615:ENPP6
gene id: 9615:ENPP6
uniprot id: A0A8C0SKK8
uniprot id: A0A8I3RYV2
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

9615:LOC476602
gene id: 9615:LOC476602
uniprot id: A0A8C0TH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

9615:RDH16
gene id: 9615:RDH16
uniprot id: A0A8C0N469
uniprot id: A0A8C0S412
uniprot id: A0A8I3N0Y3
uniprot id: A0A8I3N8I3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:TRDMT1
gene id: 9615:TRDMT1
uniprot id: A0A8C0Q2L7
uniprot id: A0A8I3NG77
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9615:P2RY8
gene id: 9615:P2RY8
uniprot id: A0A8P0TQX2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:EMR4
gene id: 9615:EMR4
uniprot id: A0A8C0TMI0
uniprot id: Q2Q419
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:ACAD11
gene id: 9615:ACAD11
uniprot id: A0A8C0MKN4
uniprot id: A0A8I3SCA7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9615:MAPT
gene id: 9615:MAPT
uniprot id: A0A8P0SIH1
names: Subcellular Location Annotation
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol

9615:XPOT
gene id: 9615:XPOT
uniprot id: A0A8C0N5R6
uniprot id: A0A8C0N666
uniprot id: A0A8I3N717
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9615:TSPAN8
gene id: 9615:TSPAN8
uniprot id: A0A8C0S7T2
uniprot id: A0A8I3PI03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:LOC607460
gene id: 9615:LOC607460
uniprot id: J9PAL7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9615:EMC9
gene id: 9615:EMC9
uniprot id: A0A8C0N0P8
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9615:SPATA18
gene id: 9615:SPATA18
uniprot id: A0A8C0SK96
uniprot id: A0A8C0YXV2
uniprot id: A0A8I3NHI2
uniprot id: A0A8I3RY91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9615:PEX12
gene id: 9615:PEX12
uniprot id: A0A8C0NU61
uniprot id: A0A8I3N3I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

9615:CLCN1
gene id: 9615:CLCN1
uniprot id: Q9MZT1
names: Disease Annotation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.
messages: Cell membrane
messages: Defects in CLCN1 are the cause of autosomal recessive myotonia congenita (MCR). MCR is a disorder of sarcolemmal excitation leading to delayed relaxation of skeletal muscle following contractions. The disease has been identified in the miniature Schnauzer breed.
messages: Homodimer.
messages: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (By similarity).
messages: Voltage-gated chloride channel. Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction.

9615:LOC611458
gene id: 9615:LOC611458
uniprot id: A0A8P0NTM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9615:CHD6
gene id: 9615:CHD6
uniprot id: A0A8C0MPJ2
uniprot id: A0A8P0NQK3
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9615:H4C9
gene id: 9615:H4C9
uniprot id: A0A8C0TQ44
uniprot id: F2Z4N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:EXOC8
gene id: 9615:EXOC8
uniprot id: A0A8C0NJH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9615:ACSL4
gene id: 9615:ACSL4
uniprot id: A0A8C0SJD0
uniprot id: A0A8I3P7X9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:DSC2
gene id: 9615:DSC2
uniprot id: A0A8C0LTT0
uniprot id: A0A8I3NHU5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9615:LBX2
gene id: 9615:LBX2
uniprot id: A0A8C0S084
uniprot id: A0A8I3NXJ5
names: Subcellular Location Annotation
messages: Nucleus

9615:GBP6
gene id: 9615:GBP6
uniprot id: A0A8P0PJ90
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9615:CACNG6
gene id: 9615:CACNG6
uniprot id: A0A8I3RTB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

9615:TTC30B
gene id: 9615:TTC30B
uniprot id: A0A8C0P1S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9615:HS3ST5
gene id: 9615:HS3ST5
uniprot id: A0A8C0M562
uniprot id: A0A8I3PLA0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:CD5
gene id: 9615:CD5
uniprot id: A0A8P0NHR1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:UBA7
gene id: 9615:UBA7
uniprot id: A0A8C0NL23
uniprot id: A0A8I3Q3R3
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9615:LYN
gene id: 9615:LYN
uniprot id: A0A8C0TT90
uniprot id: A0A8I3Q113
uniprot id: A0A8I3SAH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:TTC26
gene id: 9615:TTC26
uniprot id: A0A8C0MEA9
names: Similarity
messages: Belongs to the IFT56 family.

9615:CCL4
gene id: 9615:CCL4
uniprot id: Q68AZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Homodimer. Interacts with CCR5 (By similarity).
messages: Monokine with inflammatory and chemokinetic properties.
messages: Secreted

9615:GIMAP2
gene id: 9615:GIMAP2
uniprot id: A0A8C0PE02
uniprot id: A0A8P0SV09
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9615:ST8SIA6
gene id: 9615:ST8SIA6
uniprot id: A2VBC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:LOC100856725
gene id: 9615:LOC100856725
uniprot id: A0A8C0PRC5
names: Similarity
messages: Belongs to the PRORSD1 family.

9615:UNC5CL
gene id: 9615:UNC5CL
uniprot id: A0A8I3NPU8
names: Similarity
messages: Belongs to the unc-5 family.

9615:RAD51
gene id: 9615:RAD51
uniprot id: Q8MKI8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Expressed in the mammary gland.
messages: Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination. Interacts with BRCA1 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Interacts with the BCDX2 subcomplex RAD51C:RAD51B. Component of the homologous recombination repair (HR) complex composed of ERCC5/XPG, BRCA2, PALB2, DSS1 and RAD51. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1, and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer. Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with SPIDR; the interaction is direct and recruits RAD51 to DNA damage sites. Interacts with FIGNL1 (via N-terminal one-half region); the interaction is direct. Interacts with RAD51AP1 (via C-terminal region); the interaction is direct. Interacts with NABP2, RPA1, PALB2 and RAD51. Interacts with SWI5/C9orf119, and at lower level with SFR1/MEIR5. Interacts with hyperphosphorylated RPA2; this interaction is necessary for efficient recruitment to chromatin in response to DNA damage. Interacts with SWSAP1; involved in homologous recombination repair. Interacts with PARPBP, BRCA2 and RECQL5; these interactions interfere with the formation of the RAD51-DNA homologous recombination structure. Interacts with POLQ; POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends. Interacts with FBH1. Interacts with POLN. Interacts with RFWD3. Interacts with the MCM8-MCM9 complex; the interaction recruits RAD51 to DNA damage sites (By similarity). Component of a multiprotein complex with MEIOB and SPATA22. Interacts with the complex BRME1:HSF2BP:BRCA2 (By similarity). Interacts with HELQ; stimulating HELQ DNA helic…
messages: Mitochondrion matrix
messages: Nucleus
messages: Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair.
messages: Ubiquitinated by the SCF(FBH1) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. Ubiquitinated by RFWD3 in response to DNA damage: ubiquitination leads to degradation by the proteasome, promoting homologous recombination.
messages: centrosome
messages: perinuclear region

9615:AHCYL2
gene id: 9615:AHCYL2
uniprot id: A0A8C0PHF7
uniprot id: A0A8C0S5X6
uniprot id: A0A8C0YU80
uniprot id: A0A8I3PDP1
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9615:HTR5A
gene id: 9615:HTR5A
uniprot id: A0A8C0NXC7
uniprot id: A0A8I3NMV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:TSHZ3
gene id: 9615:TSHZ3
uniprot id: A0A8C0Q4I3
uniprot id: A0A8P0TP56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9615:ATF1
gene id: 9615:ATF1
uniprot id: A0A8C0PHZ7
uniprot id: A0A8I3NUJ6
uniprot id: A0A8I3RZ79
names: Subcellular Location Annotation
messages: Nucleus

9615:SLC9C1
gene id: 9615:SLC9C1
uniprot id: A0A8I3Q227
uniprot id: A0A8I3QIZ2
uniprot id: A0A8I3QRU1
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9615:MAOB
gene id: 9615:MAOB
uniprot id: Q7YRB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

9615:CAPZB
gene id: 9615:CAPZB
uniprot id: A0A8C0MPT3
uniprot id: A0A8I3MHS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

9615:SLC9A8
gene id: 9615:SLC9A8
uniprot id: A0A8P0NDH3
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9615:FSCN3
gene id: 9615:FSCN3
uniprot id: A0A8C0MU63
uniprot id: A0A8I3PW46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9615:LOC479816
gene id: 9615:LOC479816
uniprot id: A0A8I3MKN2
names: Subcellular Location Annotation
messages: Membrane

9615:TMEM231
gene id: 9615:TMEM231
uniprot id: A0A8P0SP03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

9615:MFSD5
gene id: 9615:MFSD5
uniprot id: A0A8C0TH98
uniprot id: A0A8I3S251
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

9615:GATA5
gene id: 9615:GATA5
uniprot id: A0A8C0N6R0
uniprot id: A0A8I3RZQ7
names: Subcellular Location Annotation
messages: Nucleus

9615:HMGA1
gene id: 9615:HMGA1
uniprot id: Q6URC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HMGA family.
messages: Chromosome
messages: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity).
messages: Interacts with HIPK2.
messages: Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation may modulate DNA-binding affinity (By similarity).
messages: Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
messages: Nucleus

9615:GHRL
gene id: 9615:GHRL
uniprot id: Q9BEF8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Amidation of Leu-98 is essential for obestatin activity.
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity).
messages: O-octanoylated by GOAT/MBOAT4 (By similarity). O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
messages: Secreted

9615:SLC18A1
gene id: 9615:SLC18A1
uniprot id: A0A8P0NC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9615:LOC481841
gene id: 9615:LOC481841
uniprot id: A0A8C0RN11
uniprot id: A0A8I3NC82
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9615:CHRD
gene id: 9615:CHRD
uniprot id: A0A8C0MSV0
uniprot id: A0A8P0NET3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
messages: Secreted

9615:CDKN1A
gene id: 9615:CDKN1A
uniprot id: A0A7I8E886
names: Similarity
messages: Belongs to the CDI family.

9615:GSX1
gene id: 9615:GSX1
uniprot id: A0A8C0P1A5
uniprot id: A0A8I3PQR6
names: Subcellular Location Annotation
messages: Nucleus

9615:PVALB
gene id: 9615:PVALB
uniprot id: A0A8C0SA21
uniprot id: A0A8I3N7Z7
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9615:APP
gene id: 9615:APP
uniprot id: A0A8C0TFV8
uniprot id: A0A8C0TG24
uniprot id: A0A8C0TGH9
uniprot id: A0A8C0Z3X8
uniprot id: A0A8I3P9H6
uniprot id: A0A8I3RZM5
uniprot id: A0A8I3S2G8
uniprot id: A0A8I3S2H9
uniprot id: Q56JK4
uniprot id: Q56JK6
uniprot id: Q6RH28
uniprot id: Q6RH29
uniprot id: Q6RH30
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Secreted
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9615:SYNJ1
gene id: 9615:SYNJ1
uniprot id: A0A8P0T4P4
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9615:RAB11A
gene id: 9615:RAB11A
uniprot id: P62490
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with RAB11FIP5 (By similarity). Interacts with STXBP6 (By similarity). Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39. Interacts with EXOC6 in a GTP-dependent manner. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5. Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner. Interacts with TBC1D12. Interacts with DEF6 (By similarity).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (By similarity). Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (PubMed:19451275). May also play a role in melanosome transport and release from melanocytes (By similarity).
messages: phagosome

9615:PATL1
gene id: 9615:PATL1
uniprot id: A0A8I3S2D6
names: Similarity
messages: Belongs to the PAT1 family.

9615:MAN1A2
gene id: 9615:MAN1A2
uniprot id: A0A8C0SHA7
uniprot id: A0A8I3Q6M3
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9615:EI24
gene id: 9615:EI24
uniprot id: A0A8C0SYL9
uniprot id: A0A8I3NCD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

9615:TCIRG1
gene id: 9615:TCIRG1
uniprot id: A0A8C0YR98
uniprot id: A0A8P0SFX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9615:CCNB3
gene id: 9615:CCNB3
uniprot id: Q659K0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I (By similarity).
messages: Interacts with CDK2 kinase.
messages: Nucleus
messages: The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1 (By similarity).

9615:CRYGS
gene id: 9615:CRYGS
uniprot id: A2IBY7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

9615:SLC46A3
gene id: 9615:SLC46A3
uniprot id: A0A8C0Z0Y0
uniprot id: A0A8I3S3B6
names: Subcellular Location Annotation
messages: Membrane

9615:TEKT4
gene id: 9615:TEKT4
uniprot id: A0A8I3PMH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9615:RALA
gene id: 9615:RALA
uniprot id: A0A8C0M811
uniprot id: A0A8I3PAK3
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9615:TOMM40L
gene id: 9615:TOMM40L
uniprot id: A0A8I3Q0N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:PRDX1
gene id: 9615:PRDX1
uniprot id: A0A8C0SYI9
uniprot id: A0A8P0T4S3
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9615:IRX2
gene id: 9615:IRX2
uniprot id: A0A8C0N5G3
uniprot id: A0A8I3PP48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9615:SLC27A1
gene id: 9615:SLC27A1
uniprot id: A0A8C0SLA2
uniprot id: A0A8I3PTX2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:DYNC1I1
gene id: 9615:DYNC1I1
uniprot id: A0A8C0RNB8
uniprot id: A0A8C0SKN6
uniprot id: A0A8I3S4U5
uniprot id: A0A8I3S4X0
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9615:OXA1L
gene id: 9615:OXA1L
uniprot id: A0A8I3MJX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9615:NMNAT1
gene id: 9615:NMNAT1
uniprot id: A0A8C0SQM7
uniprot id: A0A8I3RQT1
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9615:CASTOR1
gene id: 9615:CASTOR1
uniprot id: A0A8C0Z4H3
uniprot id: A0A8I3P8W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

9615:HSPA8
gene id: 9615:HSPA8
uniprot id: A0A8C0LZQ6
uniprot id: A0A8I3NK47
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9615:ADORA2B
gene id: 9615:ADORA2B
uniprot id: Q6W3F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).

9615:SLC25A39
gene id: 9615:SLC25A39
uniprot id: A0A8C0YZ48
uniprot id: A0A8I3RW24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9615:C20H19orf77
gene id: 9615:C20H19orf77
uniprot id: A0A8P0NKC6
names: Subcellular Location Annotation
messages: Membrane

9615:AGK
gene id: 9615:AGK
uniprot id: A0A8C0MKV6
uniprot id: A0A8I3Q635
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9615:OR6AA7
gene id: 9615:OR6AA7
uniprot id: A0A8C0SR16
uniprot id: A0A8I3NWT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:TGM1
gene id: 9615:TGM1
uniprot id: Q9GLK0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity).
messages: Interacts with PLAAT4.
messages: Membrane
messages: Palmitoylated.
messages: The membrane anchorage region possesses a cluster of five cysteines within which fatty acid(s) may become thioester-linked. It is subject to phorbol ester-stimulated phosphorylation and is hypersensitive to proteolysis, which releases the enzyme in a soluble form.
messages: Tyrosine-phosphorylated.

9615:ISOC2
gene id: 9615:ISOC2
uniprot id: A0A8C0LZ52
uniprot id: A0A8C0LZ76
uniprot id: A0A8I3MCL0
uniprot id: A0A8I3MX56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isochorismatase family.
messages: Cytoplasm
messages: Interacts with CDKN2A.
messages: Nucleus

9615:PHKB
gene id: 9615:PHKB
uniprot id: A0A8C0T6A9
uniprot id: A0A8I3NA07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9615:GCNT2
gene id: 9615:GCNT2
uniprot id: A0A8C0RJN6
uniprot id: A0A8I3P909
uniprot id: A0A8I3PEJ2
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9615:RBM15
gene id: 9615:RBM15
uniprot id: A0A8C0NR66
uniprot id: A0A8I3MEV5
names: Similarity
messages: Belongs to the RRM Spen family.

9615:LOC491028
gene id: 9615:LOC491028
uniprot id: A0A8I3NFQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9615:STX16
gene id: 9615:STX16
uniprot id: A0A8C0NM40
uniprot id: A0A8C0RMQ0
uniprot id: A0A8C0T283
uniprot id: A0A8I3NME0
uniprot id: A0A8I3NQH2
uniprot id: A0A8I3NQI7
uniprot id: A0A8P0T0W8
names: Similarity
messages: Belongs to the syntaxin family.

9615:MLLT11
gene id: 9615:MLLT11
uniprot id: A0A8C0MMI6
uniprot id: A0A8I3PMH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9615:DHX9
gene id: 9615:DHX9
uniprot id: A0A8C0M1F0
uniprot id: A0A8I3RTG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9615:B3GALT6
gene id: 9615:B3GALT6
uniprot id: Q257A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:VAMP1
gene id: 9615:VAMP1
uniprot id: A0A8C0T8Z2
uniprot id: A0A8P0T525
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9615:GFAP
gene id: 9615:GFAP
uniprot id: A0A8C0SII5
uniprot id: A0A8C0YXL1
uniprot id: A0A8I3RTB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
messages: Interacts with SYNM.

9615:CAMKMT
gene id: 9615:CAMKMT
uniprot id: A0A8C0NET7
uniprot id: A0A8P0S8M4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:CLK2
gene id: 9615:CLK2
uniprot id: A0A8C0PHA5
uniprot id: A0A8I3NI96
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:TMLHE
gene id: 9615:TMLHE
uniprot id: A0A8C0TFY1
uniprot id: A0A8P0NL32
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

9615:MRPL54
gene id: 9615:MRPL54
uniprot id: A0A8C0M9D7
uniprot id: A0A8I3MWS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9615:TYR
gene id: 9615:TYR
uniprot id: P54834
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tyrosinase family.
messages: Binds 2 copper ions per subunit.
messages: Forms an OPN3-dependent complex with DCT in response to blue light in melanocytes.
messages: Glycosylated.
messages: Melanosome
messages: Melanosome membrane
messages: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity).

9615:OR13C11C
gene id: 9615:OR13C11C
uniprot id: H9GWR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:PRORP
gene id: 9615:PRORP
uniprot id: A0A8C0MGJ5
uniprot id: A0A8I3MEK7
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9615:ARSH
gene id: 9615:ARSH
uniprot id: Q32KH8
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Membrane
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:TRAPPC13
gene id: 9615:TRAPPC13
uniprot id: A0A8C0Q8F9
uniprot id: A0A8C0RB32
uniprot id: A0A8I3N472
uniprot id: A0A8I3NFN1
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9615:CDK2AP2
gene id: 9615:CDK2AP2
uniprot id: A0A8C0PGV6
uniprot id: A0A8I3ND43
names: Similarity
messages: Belongs to the CDK2AP family.

9615:ANGPT1
gene id: 9615:ANGPT1
uniprot id: Q60FC1
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity).
messages: Glycosylated.
messages: Secreted

9615:RPS27L
gene id: 9615:RPS27L
uniprot id: A0A8C0Z4Z2
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9615:GAL3ST1
gene id: 9615:GAL3ST1
uniprot id: A1IGX8
uniprot id: A1IGX9
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9615:SLC41A3
gene id: 9615:SLC41A3
uniprot id: A0A8C0SC87
uniprot id: A0A8P0TDH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9615:DRD1
gene id: 9615:DRD1
uniprot id: A0A8I3RQT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9615:NIPSNAP2
gene id: 9615:NIPSNAP2
uniprot id: A0A8C0LSW1
uniprot id: A0A8C0LTB0
uniprot id: A0A8I3NCW1
uniprot id: A0A8I3NCZ6
names: Similarity
messages: Belongs to the NipSnap family.

9615:TMEM63B
gene id: 9615:TMEM63B
uniprot id: A0A8C0MT99
uniprot id: A0A8C0MUI7
uniprot id: A0A8I3NFM3
uniprot id: A0A8I3NGE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9615:STX10
gene id: 9615:STX10
uniprot id: A0A8C0TIR9
uniprot id: A0A8I3Q3H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9615:ACTL9
gene id: 9615:ACTL9
uniprot id: A0A8C0P1D2
uniprot id: A0A8I3N304
names: Similarity
messages: Belongs to the actin family.

9615:IL10RB
gene id: 9615:IL10RB
uniprot id: F1PS12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

9615:SRD5A2
gene id: 9615:SRD5A2
uniprot id: A0A8C0NNA6
uniprot id: A0A8I3NQ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9615:PPP2R5B
gene id: 9615:PPP2R5B
uniprot id: A0A8C0TEY5
uniprot id: A0A8P0NFV2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9615:ANAPC1
gene id: 9615:ANAPC1
uniprot id: A0A8C0NPJ3
names: Similarity
messages: Belongs to the APC1 family.

9615:INTS10
gene id: 9615:INTS10
uniprot id: A0A8C0P7A1
uniprot id: A0A8C0PH73
uniprot id: A0A8C0STH1
uniprot id: A0A8I3P7T7
uniprot id: A0A8I3S224
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9615:POLH
gene id: 9615:POLH
uniprot id: A0A8I3N3K2
names: Subcellular Location Annotation
messages: Nucleus

9615:NCLN
gene id: 9615:NCLN
uniprot id: A0A8C0S144
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

9615:RPL17
gene id: 9615:RPL17
uniprot id: A0A8C0YXW1
uniprot id: A0A8I3NZS5
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9615:XG
gene id: 9615:XG
uniprot id: A0A8C0YWF3
uniprot id: A0A8P0SG06
names: Similarity
messages: Belongs to the CD99 family.

9615:UNC119
gene id: 9615:UNC119
uniprot id: A0A8C0RJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDE6D/unc-119 family.
messages: spindle

9615:APOM
gene id: 9615:APOM
uniprot id: A0A8C0MAQ8
uniprot id: A0A8I3NKJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9615:PDE1B
gene id: 9615:PDE1B
uniprot id: A0A8C0SZ88
uniprot id: A0A8C0SZN7
uniprot id: A0A8C0T2R1
uniprot id: A0A8I3P1C7
uniprot id: A0A8I3S1V6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:NEU1
gene id: 9615:NEU1
uniprot id: A0A8C0SEP1
uniprot id: A0A8P0N3W0
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9615:STARD6
gene id: 9615:STARD6
uniprot id: A0A8C0MEE3
uniprot id: A0A8I3N3G7
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9615:OR1P1
gene id: 9615:OR1P1
uniprot id: A4GXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SLC26A3
gene id: 9615:SLC26A3
uniprot id: A0A8C0P548
uniprot id: A0A8P0N6N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Chloride/bicarbonate exchanger.
messages: Membrane

9615:GJB2
gene id: 9615:GJB2
uniprot id: A0A8C0PAL1
uniprot id: J9NXR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9615:ISY1
gene id: 9615:ISY1
uniprot id: A0A8C0NEB1
uniprot id: F1PV40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9615:SLC26A9
gene id: 9615:SLC26A9
uniprot id: A0A8C0MKK0
uniprot id: A0A8I3QEK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport.
messages: Membrane

9615:TRIP10
gene id: 9615:TRIP10
uniprot id: A0A8C0TLT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Lysosome
messages: Membrane
messages: cell cortex

9615:BORCS8
gene id: 9615:BORCS8
uniprot id: A0A8C0TI26
uniprot id: A0A8I3PCU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9615:COA5
gene id: 9615:COA5
uniprot id: A0A8C0YZQ4
uniprot id: A0A8I3NY56
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9615:SETDB1
gene id: 9615:SETDB1
uniprot id: A0A8C0SCA0
uniprot id: A0A8I3PJ60
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9615:SENP1
gene id: 9615:SENP1
uniprot id: A0A8P0NBE2
names: Similarity
messages: Belongs to the peptidase C48 family.

9615:GGTA1
gene id: 9615:GGTA1
uniprot id: A0A8C0MNE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9615:ALOXE3
gene id: 9615:ALOXE3
uniprot id: A0A8C0NZG2
uniprot id: A0A8P0TD16
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:POLR2M
gene id: 9615:POLR2M
uniprot id: A0A8C0TZZ2
uniprot id: A0A8P0PK22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

9615:PAPSS1
gene id: 9615:PAPSS1
uniprot id: A0A8P0NDD9
uniprot id: A0A8P0NXQ1
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9615:PICALM
gene id: 9615:PICALM
uniprot id: A0A8C0MYU4
uniprot id: A0A8C0TIL0
uniprot id: A0A8C0TKR3
uniprot id: A0A8I3MXF9
uniprot id: A0A8I3N1R6
uniprot id: A0A8I3N505
uniprot id: A0A8I3RU23
uniprot id: A0A8I3RVS6
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9615:H2BU1
gene id: 9615:H2BU1
uniprot id: A0A8C0S0S9
uniprot id: A0A8I3N371
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:TYRO3
gene id: 9615:TYRO3
uniprot id: A0A8I3Q6G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

9615:TRAK2
gene id: 9615:TRAK2
uniprot id: A0A8C0TGN6
uniprot id: A0A8I3QM35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9615:ZBTB22
gene id: 9615:ZBTB22
uniprot id: Q5TJE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:PPIL2
gene id: 9615:PPIL2
uniprot id: A0A8C0TKB6
uniprot id: A0A8I3PX74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9615:HMGN4
gene id: 9615:HMGN4
uniprot id: A0A8C0QRY7
uniprot id: A0A8I3NZG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9615:SHQ1
gene id: 9615:SHQ1
uniprot id: A0A8I3NGV1
names: Similarity
messages: Belongs to the SHQ1 family.

9615:NFU1
gene id: 9615:NFU1
uniprot id: A0A8I3PKZ1
names: Similarity
messages: Belongs to the NifU family.

9615:ACAN
gene id: 9615:ACAN
uniprot id: A0A8P0PE62
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:CSTA
gene id: 9615:CSTA
uniprot id: A0A8C0N313
uniprot id: F1PHB6
names: Similarity
messages: Belongs to the cystatin family.

9615:ADNP
gene id: 9615:ADNP
uniprot id: A0A8C0SDU4
uniprot id: A0A8P0PL08
names: Subcellular Location Annotation
messages: Nucleus

9615:TIMM44
gene id: 9615:TIMM44
uniprot id: A0A8C0NHF8
uniprot id: A0A8I3SBU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

9615:LOC106559787
gene id: 9615:LOC106559787
uniprot id: A0A8C0N2B2
uniprot id: A0A8I3NAG9
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9615:MTR
gene id: 9615:MTR
uniprot id: A0A8C0PSR8
uniprot id: A0A8I3MG95
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

9615:ARPC3
gene id: 9615:ARPC3
uniprot id: A0A8C0RRY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9615:PNPLA4
gene id: 9615:PNPLA4
uniprot id: A0A8C0SJA3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TMEM138
gene id: 9615:TMEM138
uniprot id: A0A8C0QDF6
uniprot id: A0A8I3NCD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9615:CCZ1
gene id: 9615:CCZ1
uniprot id: A0A8C0NPW4
uniprot id: A0A8I3N3B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCZ1 family.
messages: Lysosome membrane

9615:LOC489516
gene id: 9615:LOC489516
uniprot id: A0A8C0M9E9
uniprot id: A0A8I3MLX8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:ANO5
gene id: 9615:ANO5
uniprot id: A0A8C0NPM4
uniprot id: A0A8I3S651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

9615:MAP6
gene id: 9615:MAP6
uniprot id: A0A8P0SAW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

9615:FMO3
gene id: 9615:FMO3
uniprot id: Q95LA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Microsome membrane

9615:PDK4
gene id: 9615:PDK4
uniprot id: A0A8C0SM54
uniprot id: A0A8I3PLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9615:CES1
gene id: 9615:CES1
uniprot id: Q95N05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9615:MAP3K7
gene id: 9615:MAP3K7
uniprot id: A0A8C0MMM2
uniprot id: A0A8C0SGC2
uniprot id: A0A8I3MWV5
uniprot id: A0A8I3N7L6
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9615:AHR
gene id: 9615:AHR
uniprot id: A0A8I3RSX6
names: Subcellular Location Annotation
messages: Cytoplasm

9615:OR56B2
gene id: 9615:OR56B2
uniprot id: A0A8C0MUR3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ADAM17
gene id: 9615:ADAM17
uniprot id: A0A8C0Q8D6
uniprot id: A0A8I3PUH7
uniprot id: A0A8I3Q5Z6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SPEM1
gene id: 9615:SPEM1
uniprot id: A0A8C0RK63
uniprot id: A0A8I3PJ93
names: Subcellular Location Annotation
messages: Membrane

9615:IL2
gene id: 9615:IL2
uniprot id: Q29416
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9615:KIF15
gene id: 9615:KIF15
uniprot id: A0A8C0Z2D7
uniprot id: A0A8P0NFS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: spindle

9615:ZFP36L2
gene id: 9615:ZFP36L2
uniprot id: A0A8P0SS70
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9615:RNASE12
gene id: 9615:RNASE12
uniprot id: A0A8I3S6M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9615:INO80D
gene id: 9615:INO80D
uniprot id: A0A8C0MJU8
uniprot id: A0A8I3PD42
names: Subcellular Location Annotation
messages: Nucleus

9615:DZIP1
gene id: 9615:DZIP1
uniprot id: A0A8C0YZ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

9615:UPK1A
gene id: 9615:UPK1A
uniprot id: A0A8C0MF92
uniprot id: A0A8P0N9C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:MAP1LC3A
gene id: 9615:MAP1LC3A
uniprot id: A0A8C0P1P2
uniprot id: A0A8I3RZ71
names: Similarity
messages: Belongs to the ATG8 family.

9615:FUNDC1
gene id: 9615:FUNDC1
uniprot id: A0A8C0SMZ4
uniprot id: A0A8I3S6M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9615:SRP72
gene id: 9615:SRP72
uniprot id: P33731
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6413076). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:6413076). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:8388879, PubMed:6413076). Can bind 7SL RNA with low affinity (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Heterodimer with SRP68 (PubMed:8388879, PubMed:6413076). SRP68-SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (PubMed:8388879, PubMed:6413076). Component of a signal recognition particle consisting of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6938958, PubMed:6413076). Within the SRP complex, interacts with SRP68 (via C-terminus) (PubMed:8388879, PubMed:6413076).

9615:FGG
gene id: 9615:FGG
uniprot id: A0A8C0SFJ2
uniprot id: A0A8I3N8Y1
uniprot id: A0A8I3NPH9
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9615:CCNO
gene id: 9615:CCNO
uniprot id: A0A8C0Q0H0
uniprot id: A0A8I3QB07
names: Similarity
messages: Belongs to the cyclin family.

9615:DTD2
gene id: 9615:DTD2
uniprot id: A0A8C0YXX0
uniprot id: A0A8I3RWR4
names: Similarity
messages: Belongs to the DTD family.

9615:VEGFB
gene id: 9615:VEGFB
uniprot id: A0A8C0N946
uniprot id: A0A8P0SJ74
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9615:THRAP3
gene id: 9615:THRAP3
uniprot id: A0A8C0P4V2
uniprot id: A0A8I3QB39
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9615:STX17
gene id: 9615:STX17
uniprot id: A0A8C0TCP4
names: Similarity
messages: Belongs to the syntaxin family.

9615:XK
gene id: 9615:XK
uniprot id: A0A8C0RGC7
uniprot id: A0A8I3PT94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9615:ALKBH5
gene id: 9615:ALKBH5
uniprot id: A0A8C0RA14
uniprot id: A0A8P0SMG1
names: Subcellular Location Annotation
names: Subunit
messages: Monomer.
messages: Nucleus speckle

9615:MRPS10
gene id: 9615:MRPS10
uniprot id: A0A8C0RD71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9615:EGR2
gene id: 9615:EGR2
uniprot id: A0A8C0MVC3
uniprot id: A0A8I3MBA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9615:FXYD1
gene id: 9615:FXYD1
uniprot id: A0A8C0Q6J0
uniprot id: A0A8I3MRH3
names: Similarity
messages: Belongs to the FXYD family.

9615:IMP3
gene id: 9615:IMP3
uniprot id: A0A8C0MSU6
uniprot id: A0A8I3PD02
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9615:SLC20A2
gene id: 9615:SLC20A2
uniprot id: A0A8C0Q231
uniprot id: A0A8C0Q3V5
uniprot id: A0A8I3N1I1
uniprot id: A0A8I3N1J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

9615:EIF2A
gene id: 9615:EIF2A
uniprot id: A0A8C0MZQ4
uniprot id: A0A8I3PNA6
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9615:B3GNT7
gene id: 9615:B3GNT7
uniprot id: A0A8I3PJJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:ITGB6
gene id: 9615:ITGB6
uniprot id: A0A8C0N458
uniprot id: A0A8C0TDZ7
uniprot id: A0A8P0NVZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9615:PBX4
gene id: 9615:PBX4
uniprot id: A0A8P0NF27
uniprot id: A0A8P0NFU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9615:LDB2
gene id: 9615:LDB2
uniprot id: A0A8C0M2G7
names: Similarity
messages: Belongs to the LDB family.

9615:H4C8
gene id: 9615:H4C8
uniprot id: F2Z4N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:KRT39
gene id: 9615:KRT39
uniprot id: A0A8P0NLV5
names: Similarity
messages: Belongs to the intermediate filament family.

9615:PLSCR1
gene id: 9615:PLSCR1
uniprot id: A0A8C0MKS2
uniprot id: A0A8I3PEX0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9615:VBP1
gene id: 9615:VBP1
uniprot id: A0A8C0TD93
uniprot id: A0A8I3P4S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9615:ELF3
gene id: 9615:ELF3
uniprot id: A0A8P0NCJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:CHMP1A
gene id: 9615:CHMP1A
uniprot id: A0A8C0TP69
uniprot id: A0A8I3ML36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9615:IPPK
gene id: 9615:IPPK
uniprot id: A0A8C0M0Y0
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9615:MYMK
gene id: 9615:MYMK
uniprot id: A0A8C0LWV2
uniprot id: A0A8I3RVZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9615:TJP2
gene id: 9615:TJP2
uniprot id: Q95168
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Homodimer, and heterodimer with TJP1/ZO1 and UBN1. Interacts with SCRIB (By similarity). Interacts with occludin and SAFB. Interaction with SAFB occurs in the nucleus. Interacts with USP53 (via the C-terminal region) (By similarity).
messages: Nucleus
messages: Phosphorylated.
messages: Plays a role in tight junctions and adherens junctions.
messages: tight junction

9615:STRIP2
gene id: 9615:STRIP2
uniprot id: A0A8C0YTB4
uniprot id: E2RJF2
names: Similarity
messages: Belongs to the STRIP family.

9615:LIMK2
gene id: 9615:LIMK2
uniprot id: A0A8C0RN34
uniprot id: A0A8C0TMY9
uniprot id: A0A8I3S5T7
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9615:KCNE2
gene id: 9615:KCNE2
uniprot id: A0A8C0T7F7
uniprot id: Q864T0
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9615:ZC3HAV1
gene id: 9615:ZC3HAV1
uniprot id: A0A8I3MXY4
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:PCNX4
gene id: 9615:PCNX4
uniprot id: A0A8C0PI61
uniprot id: A0A8I3S2U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9615:TRMU
gene id: 9615:TRMU
uniprot id: A0A8C0QQ09
uniprot id: A0A8I3N2T0
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

9615:TMEM229B
gene id: 9615:TMEM229B
uniprot id: A0A8C0YVA9
uniprot id: A0A8I3RST6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9615:RPS10
gene id: 9615:RPS10
uniprot id: A0A8C0M508
uniprot id: A0A8I3PQS5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9615:CKAP2L
gene id: 9615:CKAP2L
uniprot id: A0A8C0RCV8
uniprot id: A0A8C0RCY4
names: Similarity
messages: Belongs to the CKAP2 family.

9615:PNN
gene id: 9615:PNN
uniprot id: A0A8P0NFV8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

9615:SEC13
gene id: 9615:SEC13
uniprot id: A0A8C0RD48
uniprot id: A0A8I3RVL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

9615:DPM1
gene id: 9615:DPM1
uniprot id: A0A8I3PV83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9615:CCDC153
gene id: 9615:CCDC153
uniprot id: A0A8C0T7V6
names: Similarity
messages: Belongs to the UPF0610 family.

9615:PLA2G2D
gene id: 9615:PLA2G2D
uniprot id: A0A8I3MN96
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9615:NRF1
gene id: 9615:NRF1
uniprot id: A0A8C0S352
uniprot id: A0A8I3PAK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9615:MSRB2
gene id: 9615:MSRB2
uniprot id: A0A8C0Q9V7
uniprot id: A0A8I3N101
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9615:GGCX
gene id: 9615:GGCX
uniprot id: A0A8C0N2L1
uniprot id: A0A8I3NVM5
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
messages: Membrane

9615:ALDH18A1
gene id: 9615:ALDH18A1
uniprot id: A0A8C0Z5M9
uniprot id: A0A8I3PPU5
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9615:DNAL4
gene id: 9615:DNAL4
uniprot id: A0A8C0RM40
uniprot id: A0A8I3PKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9615:SUPT16H
gene id: 9615:SUPT16H
uniprot id: A0A8C0SKZ4
uniprot id: A0A8I3PYF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9615:CCS
gene id: 9615:CCS
uniprot id: A0A8C0SJL5
uniprot id: A0A8I3NJ97
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9615:ANAPC11
gene id: 9615:ANAPC11
uniprot id: A0A8C0NL52
uniprot id: A0A8I3N198
names: Similarity
messages: Belongs to the RING-box family.

9615:TXLNB
gene id: 9615:TXLNB
uniprot id: A0A8C0M4H2
names: Similarity
messages: Belongs to the taxilin family.

9615:LOC102156298
gene id: 9615:LOC102156298
uniprot id: A0A8P0TDR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:PFDN2
gene id: 9615:PFDN2
uniprot id: A0A8C0NU96
uniprot id: A0A8I3Q7K8
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9615:METTL8
gene id: 9615:METTL8
uniprot id: A0A8C0NCV5
uniprot id: A0A8I3PTX1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9615:UBE2F
gene id: 9615:UBE2F
uniprot id: A0A8I3Q1K9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:GPR137C
gene id: 9615:GPR137C
uniprot id: A0A8I3MN57
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9615:ABCD1
gene id: 9615:ABCD1
uniprot id: A0A8C0T0G0
uniprot id: A0A8I3PH78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9615:IREB2
gene id: 9615:IREB2
uniprot id: A0A8C0MSG6
uniprot id: A0A8I3NZI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

9615:SPATA20
gene id: 9615:SPATA20
uniprot id: A0A8C0TZT1
uniprot id: A0A8I3RXI1
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

9615:OGN
gene id: 9615:OGN
uniprot id: A0A8P0S8G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

9615:TM4SF4
gene id: 9615:TM4SF4
uniprot id: A0A8C0MUM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9615:RAB5A
gene id: 9615:RAB5A
uniprot id: P18066
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Early endosome membrane
messages: Endosome membrane
messages: Interacts with GDI1; this promotes dissociation from membranes; phosphorylation at Ser-84 disrupts this interaction (By similarity). Interacts with GDI2; phosphorylation at Ser-84 disrupts the interaction (By similarity). Binds EEA1. Interacts with ALS2CL, SUN2, ZFYVE20 and RUFY1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB (By similarity). Interacts with RABEP1 and RINL (PubMed:8521472, PubMed:21419809). Interacts with OCRL and INPP5F. May be a component of a complex composed of RAB5A, DYN2 and PIK3C3 (By similarity). Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (PubMed:20048159). Interacts with CLN5 (By similarity). Interacts with APPL2 (By similarity). Interacts with F8A1/F8A2/F8A3 (By similarity). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity).
messages: Melanosome
messages: Membrane
messages: Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:8521472). RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
messages: cytosol
messages: phagosome membrane
messages: ruffle

9615:IMPACT
gene id: 9615:IMPACT
uniprot id: A0A8P0NPN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

9615:EVA1A
gene id: 9615:EVA1A
uniprot id: A0A8C0Q9E2
uniprot id: A0A8I3P5D0
names: Similarity
messages: Belongs to the EVA1 family.

9615:LOC106560070
gene id: 9615:LOC106560070
uniprot id: A0A8C0NN23
uniprot id: A0A8I3PXF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:SLC25A14
gene id: 9615:SLC25A14
uniprot id: E2R4C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:SUPT5H
gene id: 9615:SUPT5H
uniprot id: A0A8C0SID0
uniprot id: A0A8C0SIG6
uniprot id: A0A8I3MSR1
uniprot id: A0A8I3RS47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9615:CORO2A
gene id: 9615:CORO2A
uniprot id: A0A8P0NZR3
names: Similarity
messages: Belongs to the WD repeat coronin family.

9615:MAP3K8
gene id: 9615:MAP3K8
uniprot id: A0A8I3N8I4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9615:SLC13A5
gene id: 9615:SLC13A5
uniprot id: A0A8C0RNQ2
uniprot id: A0A8I3MEW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9615:OR2F1D
gene id: 9615:OR2F1D
uniprot id: A0A8C0MLA6
uniprot id: A0A8I3NMC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CACNB1
gene id: 9615:CACNB1
uniprot id: A0A8C0PW50
uniprot id: A0A8I3NL57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Membrane
messages: sarcolemma

9615:CHMP4A
gene id: 9615:CHMP4A
uniprot id: A0A8I3N241
names: Similarity
messages: Belongs to the SNF7 family.

9615:NAA60
gene id: 9615:NAA60
uniprot id: A0A8C0RBH6
uniprot id: A0A8P0NKL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

9615:PDE4D
gene id: 9615:PDE4D
uniprot id: A0A8C0LU39
uniprot id: A0A8C0LUJ9
uniprot id: A0A8C0LXG4
uniprot id: A0A8C0LXT1
uniprot id: A0A8C0M490
uniprot id: A0A8C0PVI8
uniprot id: A0A8C0RA18
uniprot id: A0A8I3MZQ9
uniprot id: A0A8I3N1Y7
uniprot id: A0A8I3N391
uniprot id: A0A8I3N583
uniprot id: A0A8I3N5K5
uniprot id: A0A8I3N803
uniprot id: A0A8I3RTU1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:CHUK
gene id: 9615:CHUK
uniprot id: A0A8C0Z216
uniprot id: A0A8I3P499
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:CCKAR
gene id: 9615:CCKAR
uniprot id: Q5D0K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

9615:FKRP
gene id: 9615:FKRP
uniprot id: A0A8C0Q055
uniprot id: A0A8I3MJY0
names: Similarity
messages: Belongs to the LicD transferase family.

9615:ZCCHC4
gene id: 9615:ZCCHC4
uniprot id: A0A8C0M8S0
uniprot id: A0A8I3N825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9615:TYROBP
gene id: 9615:TYROBP
uniprot id: A0A8C0MRH7
uniprot id: A0A8I3MB67
uniprot id: D3GGD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9615:TMEM91
gene id: 9615:TMEM91
uniprot id: A0A8C0M128
uniprot id: A0A8I3MF62
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9615:LOC480492
gene id: 9615:LOC480492
uniprot id: A0A8C0RGG1
uniprot id: J9P5K9
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9615:UQCRQ
gene id: 9615:UQCRQ
uniprot id: A0A8C0QP45
uniprot id: A0A8I3NJC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9615:CDC42SE1
gene id: 9615:CDC42SE1
uniprot id: A0A8C0SFP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9615:RHBDF2
gene id: 9615:RHBDF2
uniprot id: Q00M95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S54 family.
messages: Cell membrane
messages: Detected in retina and spleen.
messages: Endoplasmic reticulum membrane
messages: Interacts with EGF (By similarity). Interacts (via cytoplasmic N-terminus) with FRMD8/iTAP; this interaction leads to mutual protein stabilization. Interacts with ADAM17/TACE (By similarity).
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

9615:METTL26
gene id: 9615:METTL26
uniprot id: A0A8C0N2D2
names: Similarity
messages: Belongs to the UPF0585 family.

9615:CD180
gene id: 9615:CD180
uniprot id: A0A8C0PXU0
uniprot id: A0A8I3N9Z3
names: Similarity
messages: Belongs to the Toll-like receptor family.

9615:HTR1B
gene id: 9615:HTR1B
uniprot id: P79250
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).
messages: Homodimer. Heterodimer with HTR1D (By similarity).
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Palmitoylated.
messages: Phosphorylated.

9615:NRG1
gene id: 9615:NRG1
uniprot id: A0A8C0PCL7
uniprot id: A0A8C0SN71
uniprot id: A0A8I3NWS8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9615:RORB
gene id: 9615:RORB
uniprot id: A0A8C0PBT3
uniprot id: A0A8I3NN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:IFGGB1
gene id: 9615:IFGGB1
uniprot id: J7PCK9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9615:H2AZ1
gene id: 9615:H2AZ1
uniprot id: A0A8C0Z4D4
uniprot id: A0A8I3PL79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:RPL27A
gene id: 9615:RPL27A
uniprot id: A0A8C0PGQ7
uniprot id: E2RI34
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9615:NPC2
gene id: 9615:NPC2
uniprot id: A0A8C0P355
uniprot id: A0A8I3NVN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9615:MPI
gene id: 9615:MPI
uniprot id: A0A8I3P413
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9615:ERMN
gene id: 9615:ERMN
uniprot id: A0A8C0SKL8
uniprot id: A0A8I3PQX2
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9615:OR13F1
gene id: 9615:OR13F1
uniprot id: A0A8C0NQD2
uniprot id: A0A8I3ND67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CSNK2A2
gene id: 9615:CSNK2A2
uniprot id: A0A8C0RAF3
uniprot id: A0A8I3MPA1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:BCL2
gene id: 9615:BCL2
uniprot id: Q75SV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

9615:MRFAP1
gene id: 9615:MRFAP1
uniprot id: A0A8C0M379
uniprot id: A0A8I3N6W7
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9615:C16H4orf47
gene id: 9615:C16H4orf47
uniprot id: A0A8C0SCD7
uniprot id: A0A8P0SPP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0602 family.
messages: centrosome

9615:KIF1C
gene id: 9615:KIF1C
uniprot id: A0A8C0RVE3
uniprot id: A0A8I3MNQ5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9615:DEFB132
gene id: 9615:DEFB132
uniprot id: A0A8C0TCC5
uniprot id: Q30KS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:FUT8
gene id: 9615:FUT8
uniprot id: A0A8C0NYX3
uniprot id: A0A8I3MHX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9615:KCNJ14
gene id: 9615:KCNJ14
uniprot id: A0A8C0N6M7
uniprot id: A0A8I3RRG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9615:SLAMF1
gene id: 9615:SLAMF1
uniprot id: Q95MM9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts (via cytoplasmic domain) with SH2D1A and SH2D1B; SH2D1A mediates association with FYN. Interacts (via cytoplasmic domain phosphorylated on tyrosine residues) with INPP5D and PTPN11; presence of SH2D1A facilitates binding to INPP5D (By similarity). Interacts with MAP4K1. Interacts with PIK3C3, BECN1 and UVRAG; indicative for an association with PI3K complex II (PI3KC3-C2) (By similarity). Interacts with canine distemper virus HN protein; suggesting that it may serve as a receptor.
messages: Phosphorylated on tyrosine residues by FYN.
messages: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1. Mediates IL-2-independent proliferation of activated T cells during immune responses and induces IFN-gamma production. Downstreaming signaling involves INPP5D/SHIP1, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production. Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells. Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells. Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells. May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells. May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion. In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell l…
messages: The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'two-out-of-three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). Binding is mediated by either three 'prongs' (for high affinity binding involving ITSM 1) or a combination of any two also including non-phosphorylated Tyr-284 of ITSM 1. ITSM 2 needs to be phosphoryated on Tyr-334 for SH2D1A binding.

9615:ADCYAP1
gene id: 9615:ADCYAP1
uniprot id: A0A8C0PXE0
uniprot id: A0A8P0TUN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucagon family.
messages: Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
messages: Secreted

9615:CASQ2
gene id: 9615:CASQ2
uniprot id: P12637
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:3427023). Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
messages: Detected in heart muscle (at protein level).
messages: Interacts with ASPH (By similarity). Monomer, homodimer and homooligomer. Mostly monomeric in the absence of calcium. Forms higher oligomers in a calcium-dependent manner. Dimers associate to form tetramers, that then form linear homomer chains. Interacts with TRDN.
messages: N-glycosylated.
messages: Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity.
messages: Sarcoplasmic reticulum lumen

9615:DIPK2B
gene id: 9615:DIPK2B
uniprot id: A0A8C0SPS5
uniprot id: A0A8I3Q0Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9615:FZD2
gene id: 9615:FZD2
uniprot id: A0A8I3N4R2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:NASP
gene id: 9615:NASP
uniprot id: A0A8C0NKP0
uniprot id: A0A8C0NQJ9
uniprot id: A0A8P0N7C1
uniprot id: A0A8P0N7C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9615:UBIAD1
gene id: 9615:UBIAD1
uniprot id: A0A8C0NYF5
uniprot id: A0A8I3MPQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9615:MME
gene id: 9615:MME
uniprot id: A0A8C0T1M5
uniprot id: F5C3N2
names: Cofactor
messages: Binds 1 zinc ion per subunit.

9615:OGFOD1
gene id: 9615:OGFOD1
uniprot id: A0A8C0MFM2
uniprot id: A0A8I3MQV7
names: Similarity
messages: Belongs to the TPA1 family.

9615:THY1
gene id: 9615:THY1
uniprot id: A0A8C0Z1H7
uniprot id: A0A8I3NQP0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
messages: Membrane

9615:TMEM225B
gene id: 9615:TMEM225B
uniprot id: A0A8I3MNF8
uniprot id: A0A8I3MP24
names: Subcellular Location Annotation
messages: Membrane

9615:LOC477699
gene id: 9615:LOC477699
uniprot id: A0A8C0PDB0
uniprot id: A0A8P0NFR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9615:GAL
gene id: 9615:GAL
uniprot id: A0A8I3RTK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

9615:DIO1
gene id: 9615:DIO1
uniprot id: P49894
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iodothyronine deiodinase family.
messages: Endoplasmic reticulum membrane
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.

9615:JRKL
gene id: 9615:JRKL
uniprot id: A0A8C0NZ51
uniprot id: A0A8I3P7F5
names: Subcellular Location Annotation
messages: Nucleus

9615:ADRB3
gene id: 9615:ADRB3
uniprot id: O02662
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
messages: Cell membrane
messages: Interacts with ARRDC3.

9615:LOC609612
gene id: 9615:LOC609612
uniprot id: A0A8C0Z2T7
uniprot id: A0A8I3N9V0
names: Similarity
messages: Belongs to the folate receptor family.

9615:TNFRSF14
gene id: 9615:TNFRSF14
uniprot id: A0A8C0RYX0
uniprot id: E2QXY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:IAPP
gene id: 9615:IAPP
uniprot id: P17716
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calcitonin family.
messages: Interacts with IDE and INS.
messages: Secreted
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
messages: The mature protein is largely unstructured in the absence of a cognate ligand.

9615:FAM219A
gene id: 9615:FAM219A
uniprot id: A0A8I3PNW3
names: Similarity
messages: Belongs to the FAM219 family.

9615:MAGOHB
gene id: 9615:MAGOHB
uniprot id: A0A8C0SE21
uniprot id: A0A8I3PR32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9615:SLC35B1
gene id: 9615:SLC35B1
uniprot id: A0A8C0LY15
uniprot id: A0A8I3NIE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9615:OSTC
gene id: 9615:OSTC
uniprot id: P86218
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
messages: Specific component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:15835887). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:15835887, PubMed:29519914). Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex (By similarity).

9615:FGF13
gene id: 9615:FGF13
uniprot id: A0A8C0S5S3
uniprot id: A0A8I3Q444
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: dendrite
messages: filopodium
messages: growth cone
messages: sarcolemma

9615:OR2D3
gene id: 9615:OR2D3
uniprot id: A0A8C0N7X2
uniprot id: A0A8I3NCK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:GRWD1
gene id: 9615:GRWD1
uniprot id: A0A8C0RVA6
uniprot id: A0A8P0N6T9
names: Subcellular Location Annotation
messages: Nucleus

9615:ST8SIA4
gene id: 9615:ST8SIA4
uniprot id: A0A8C0NMC0
uniprot id: A0A8I3MRS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:GFI1
gene id: 9615:GFI1
uniprot id: Q5DWN0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with U2AF1L4. Component of RCOR-GFI-KDM1A-HDAC complexes. Interacts directly with RCOR1, KDM1A and HDAC2. Also interacts with HDAC1 and HDAC3. Interacts (via the zinc-finger domain) with ARIH2; the interaction prevents GFI1 ubiquitination and proteasomal degradation. Interacts with PIAS3; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity. Forms a complex with EHMT2 and HDAC1 to promote 'Lys-9' dimethylation of H3 (H3K9Me2) and repress expression of target genes. Interacts directly with EHMT2. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly with AJUBA (via ITS LIM domains); the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes and, occurs independently of the SNAG domain. Interacts with SPI1; the interaction inhibits SPI1 transcriptional activity targeted at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Interacts with RUNX1T1; the interaction represses HDAC-mediated transcriptional activity. Interacts with RELA; the interaction occurs on liposaccharide (LPS) stimulation and controls RELA DNA binding activity and regulates endotoxin-mediated TOLL-like receptor inflammatory response. Interacts (via the C-terminal zinc fingers) with ZBTB17; the interaction results in the recruitment of GFI1 to the CDKN1A/p21 and CDKNIB promoters and repression of transcription (By similarity).
messages: Nucleus
messages: The SNAG domain of GFIs is required for nuclear location and for interaction with some corepressors.
messages: Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.
messages: Ubiquitinated.
messages: Zinc fingers 3, 4 and 5 are required for DNA-binding and for interaction with SPI1.

9615:C3AR1
gene id: 9615:C3AR1
uniprot id: A0A8C0P7B3
uniprot id: A0A8I3Q2F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9615:FAM13A
gene id: 9615:FAM13A
uniprot id: A0A8C0PJ59
uniprot id: A0A8C0PSE4
uniprot id: A0A8C0RTK2
uniprot id: A0A8I3NW33
uniprot id: A0A8I3P8J6
uniprot id: A0A8P0THN1
names: Similarity
messages: Belongs to the FAM13 family.

9615:NLGN1
gene id: 9615:NLGN1
uniprot id: A0A8C0PCC8
uniprot id: A0A8I3RYP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9615:PTBP1
gene id: 9615:PTBP1
uniprot id: A0A8C0S8Q6
uniprot id: A0A8I3NY06
names: Subcellular Location Annotation
messages: Nucleus

9615:CALHM2
gene id: 9615:CALHM2
uniprot id: A0A8C0TMT6
uniprot id: A0A8I3S6F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9615:NDUFS4
gene id: 9615:NDUFS4
uniprot id: A0A8C0QK35
uniprot id: A0A8P0TST0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9615:GNA11
gene id: 9615:GNA11
uniprot id: A0A8C0YTB7
uniprot id: A0A8I3NFC7
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9615:FOXI1
gene id: 9615:FOXI1
uniprot id: A0A8C0R9D4
uniprot id: A0A8I3MFQ1
names: Subcellular Location Annotation
messages: Nucleus

9615:GRIN2A
gene id: 9615:GRIN2A
uniprot id: A0A8C0N398
uniprot id: A0A8I3NRD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9615:ADORA2A
gene id: 9615:ADORA2A
uniprot id: P11617
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (By similarity). May interact with DRD4 (By similarity). Interacts with NECAB2 (By similarity). Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (By similarity).
messages: Receptor for adenosine (PubMed:2125216). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:2125216).
messages: The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.
messages: Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).

9615:HOXB2
gene id: 9615:HOXB2
uniprot id: A0A8C0QFI9
uniprot id: A0A8P0NIA4
names: Subcellular Location Annotation
messages: Nucleus

9615:IFI35
gene id: 9615:IFI35
uniprot id: A0A8C0RAJ1
uniprot id: A0A8I3RT92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9615:ENTPD5
gene id: 9615:ENTPD5
uniprot id: A0A8C0PHE2
uniprot id: A0A8I3NSC1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:B3GALT2
gene id: 9615:B3GALT2
uniprot id: A0A8C0S8H1
uniprot id: A0A8I3PNT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:PLCD4
gene id: 9615:PLCD4
uniprot id: A0A8C0Z5H4
uniprot id: A0A8I3Q2Q7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
messages: Nucleus

9615:OR6N1
gene id: 9615:OR6N1
uniprot id: F1PCK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:HAUS1
gene id: 9615:HAUS1
uniprot id: A0A8P0SW24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9615:TMEM182
gene id: 9615:TMEM182
uniprot id: A0A8C0QQQ5
uniprot id: A0A8P0NS11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9615:PRKRA
gene id: 9615:PRKRA
uniprot id: A0A8C0T5M4
uniprot id: A0A8P0NRP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRKRA family.
messages: perinuclear region

9615:PHYKPL
gene id: 9615:PHYKPL
uniprot id: A0A8I3NDG4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9615:VDAC3
gene id: 9615:VDAC3
uniprot id: A0A8C0P3D0
uniprot id: A0A8C0Q760
uniprot id: A0A8I3RT18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

9615:C7
gene id: 9615:C7
uniprot id: A0A8P0T2K7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:FKBP5
gene id: 9615:FKBP5
uniprot id: A0A8C0NCY0
uniprot id: A0A8P0TUB8
names: Subcellular Location Annotation
messages: Nucleus

9615:LAMTOR3
gene id: 9615:LAMTOR3
uniprot id: A0A8C0RQW2
uniprot id: A0A8I3PP92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9615:SCAND1
gene id: 9615:SCAND1
uniprot id: A0A8C0S5U0
uniprot id: A0A8I3PLZ2
names: Subcellular Location Annotation
messages: Nucleus

9615:MAP1LC3C
gene id: 9615:MAP1LC3C
uniprot id: A0A8P0NSP7
names: Similarity
messages: Belongs to the ATG8 family.

9615:LOC102153143
gene id: 9615:LOC102153143
uniprot id: A0A8C0P4T4
uniprot id: A0A8I3PLS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

9615:METTL2A
gene id: 9615:METTL2A
uniprot id: A0A8C0RGJ9
uniprot id: A0A8I3P5K4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9615:NDNF
gene id: 9615:NDNF
uniprot id: A0A8C0YZX6
uniprot id: A0A8I3PP98
names: Subcellular Location Annotation
messages: Secreted

9615:LOC484867
gene id: 9615:LOC484867
uniprot id: A0A8C0T8J0
uniprot id: A0A8I3RZ52
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:DIPK1B
gene id: 9615:DIPK1B
uniprot id: A0A8C0MEF9
uniprot id: A0A8I3MZ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

9615:DSE
gene id: 9615:DSE
uniprot id: A0A8C0Q4B7
uniprot id: A0A8I3MZW8
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9615:SEMA5A
gene id: 9615:SEMA5A
uniprot id: A0A8C0TN92
uniprot id: A0A8P0P965
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:ANAPC13
gene id: 9615:ANAPC13
uniprot id: A0A8C0MQG9
uniprot id: A0A8I3QJ90
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9615:SLC6A4
gene id: 9615:SLC6A4
uniprot id: Q33E87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: focal adhesion

9615:OR13E1
gene id: 9615:OR13E1
uniprot id: A0A8C0MPP9
uniprot id: A0A8I3NAF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:STC1
gene id: 9615:STC1
uniprot id: A0A8C0TED7
uniprot id: A0A8I3P614
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9615:SLITRK5
gene id: 9615:SLITRK5
uniprot id: A0A8C0SYP0
uniprot id: A0A8I3N3Z9
names: Similarity
messages: Belongs to the SLITRK family.

9615:DCP1B
gene id: 9615:DCP1B
uniprot id: A0A8C0NWR1
uniprot id: A0A8I3QAS7
names: Similarity
messages: Belongs to the DCP1 family.

9615:CHST11
gene id: 9615:CHST11
uniprot id: A0A8I3MZ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:CCL23
gene id: 9615:CCL23
uniprot id: A0A8C0RPY4
uniprot id: A0A8I3N5K9
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9615:LOC100683471
gene id: 9615:LOC100683471
uniprot id: A0A8C0LUB8
uniprot id: A0A8I3MPR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9615:MAP3K12
gene id: 9615:MAP3K12
uniprot id: A0A8C0PNU4
uniprot id: A0A8I3NYB5
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9615:CCDC126
gene id: 9615:CCDC126
uniprot id: A0A8C0QBU6
uniprot id: A0A8I3N8E5
names: Subcellular Location Annotation
messages: Secreted

9615:MKS1
gene id: 9615:MKS1
uniprot id: A0A8C0U0I9
uniprot id: A0A8I3NYW6
names: Subcellular Location Annotation
messages: cilium basal body

9615:RAD21L1
gene id: 9615:RAD21L1
uniprot id: A0A8I3S112
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9615:CANF2
gene id: 9615:CANF2
uniprot id: O18874
names: Allergen
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Causes an allergic reaction in human.
messages: Secreted
messages: Tongue epithelial tissue and parotid gland.

9615:TBC1D7
gene id: 9615:TBC1D7
uniprot id: A0A8C0SZI2
uniprot id: A0A8C0Z0V8
uniprot id: A0A8I3PA10
uniprot id: A0A8I3PGX1
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9615:TLR8
gene id: 9615:TLR8
uniprot id: A0A8P0PHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9615:IPO4
gene id: 9615:IPO4
uniprot id: A0A8C0PZF2
names: Subcellular Location Annotation
messages: Cytoplasm

9615:SNX10
gene id: 9615:SNX10
uniprot id: A0A8C0S1V6
uniprot id: A0A8I3NGQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9615:SLC52A3
gene id: 9615:SLC52A3
uniprot id: A0A8C0MHH5
uniprot id: A0A8I3S1B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9615:PPP4R3A
gene id: 9615:PPP4R3A
uniprot id: A0A8C0PWT9
uniprot id: A0A8I3NRE9
names: Similarity
messages: Belongs to the SMEK family.

9615:S1PR5
gene id: 9615:S1PR5
uniprot id: A0A8C0T6Z5
uniprot id: A0A8I3Q0H0
names: Subcellular Location Annotation
messages: Membrane

9615:HDAC1
gene id: 9615:HDAC1
uniprot id: A0A8C0NQ85
uniprot id: A0A8I3MVP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9615:CMTM8
gene id: 9615:CMTM8
uniprot id: A0A8C0Z0K7
uniprot id: A0A8I3PH34
names: Subcellular Location Annotation
messages: Membrane

9615:MYC
gene id: 9615:MYC
uniprot id: Q28350
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity). Interacts with CIP2A; leading to the stabilization of MYC (By similarity).
messages: Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
messages: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.
messages: nucleolus
messages: nucleoplasm

9615:SAR1B
gene id: 9615:SAR1B
uniprot id: A0A8C0QFD7
uniprot id: A0A8I3NZH7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9615:RSBN1
gene id: 9615:RSBN1
uniprot id: A0A8C0PK49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9615:TJAP1
gene id: 9615:TJAP1
uniprot id: A0A8C0QEF6
uniprot id: A0A8P0NMU2
uniprot id: A0A8P0PDN3
names: Subcellular Location Annotation
messages: Membrane

9615:OVOL1
gene id: 9615:OVOL1
uniprot id: A0A8C0SRK6
uniprot id: A0A8I3PB55
names: Subcellular Location Annotation
messages: Nucleus

9615:DCLRE1C
gene id: 9615:DCLRE1C
uniprot id: A0A8C0Q8T6
uniprot id: A0A8I3P3Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9615:NOP14
gene id: 9615:NOP14
uniprot id: A0A8P0NGF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9615:GNG7
gene id: 9615:GNG7
uniprot id: A0A8C0RFD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:SLC1A7
gene id: 9615:SLC1A7
uniprot id: E1CEI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9615:SYT16
gene id: 9615:SYT16
uniprot id: A0A8C0PC82
uniprot id: A0A8I3S7K2
names: Similarity
messages: Belongs to the synaptotagmin family.

9615:DNAJA1
gene id: 9615:DNAJA1
uniprot id: A0A8C0RZG3
uniprot id: A0A8P0N4Y4
names: Subcellular Location Annotation
messages: Membrane

9615:C1QBP
gene id: 9615:C1QBP
uniprot id: A0A8C0P0Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

9615:TSSK2
gene id: 9615:TSSK2
uniprot id: A0A8C0P5X4
uniprot id: A0A8I3Q8N2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:IL12A
gene id: 9615:IL12A
uniprot id: A0A8C0TCU1
uniprot id: A0A8I3PVB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

9615:HMGB1
gene id: 9615:HMGB1
uniprot id: Q6YKA4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion. Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (By similarity).
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Endosome
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.
messages: HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4. However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance.
messages: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages.
messages: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization. Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM. Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex. Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B c…
messages: In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).
messages: Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by glycyrrhizin. Associates with the TLR4:LY96 receptor complex. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with KPNA1; involved in nuclear import. Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT. Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53. Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response. Interacts with XPO1; mediating nuclear export.
messages: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins.
messages: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding. Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance.
messages: Nucleus
messages: Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion.
messages: Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS (By similarity).
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).
messages: Secreted
messages: The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins.

9615:RARS2
gene id: 9615:RARS2
uniprot id: A0A8C0N9A0
uniprot id: A0A8I3MY44
uniprot id: A0A8I3RSY1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:LHX5
gene id: 9615:LHX5
uniprot id: A0A8C0TNM7
uniprot id: A0A8I3PGV3
names: Subcellular Location Annotation
messages: Nucleus

9615:LOC609365
gene id: 9615:LOC609365
uniprot id: A0A8C0SU15
uniprot id: A0A8C0YZN5
uniprot id: A0A8I3MKY4
uniprot id: A0A8I3MT43
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

9615:CDS1
gene id: 9615:CDS1
uniprot id: A0A8I3S2W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9615:OR4C11
gene id: 9615:OR4C11
uniprot id: A0A8C0SHN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:TBL1XR1
gene id: 9615:TBL1XR1
uniprot id: A0A8C0SU26
uniprot id: A0A8I3S1H9
names: Similarity
messages: Belongs to the WD repeat EBI family.

9615:ZNF445
gene id: 9615:ZNF445
uniprot id: A0A8C0SKI8
uniprot id: A0A8I3PGF4
names: Subcellular Location Annotation
messages: Nucleus

9615:PPP1CC
gene id: 9615:PPP1CC
uniprot id: Q8MJ46
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cleavage furrow
messages: Cytoplasm
messages: Inactivated by binding to URI1.
messages: Midbody
messages: Mitochondrion
messages: Nucleus
messages: Nucleus speckle
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PPP1R3B, PPP1R7 and CDCA2. Interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with NOM1 and PPP1R8. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with NEK2. Interacts with PPP1R42; the interaction is direct. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with FOXP3. Interacts with TMEM225 (via RVxF motif). Interacts with MKI67. Interacts with RRP1B; this targets PPP1CC to the nucleolus (By similarity). Interacts with DYNLT4 (By similarity).
messages: Phosphorylated by NEK2.
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity).
messages: kinetochore
messages: microtubule organizing center
messages: nucleolus
messages: nucleoplasm

9615:MRPL18
gene id: 9615:MRPL18
uniprot id: A0A8C0N4X7
uniprot id: A0A8I3MHG8
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9615:MIS12
gene id: 9615:MIS12
uniprot id: A0A8C0PMF0
uniprot id: A0A8I3MFK1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9615:FBXL15
gene id: 9615:FBXL15
uniprot id: E2RKN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBXL15 family.
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity).

9615:CAPN8
gene id: 9615:CAPN8
uniprot id: A0A8P0NHT2
names: Similarity
messages: Belongs to the peptidase C2 family.

9615:SBK2
gene id: 9615:SBK2
uniprot id: A0A8C0QPZ6
uniprot id: A0A8I3RQZ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:LOC102155595
gene id: 9615:LOC102155595
uniprot id: A0A8C0T897
uniprot id: A0A8I3PWR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

9615:HAO1
gene id: 9615:HAO1
uniprot id: A0A8C0P5I9
uniprot id: A0A8I3PUM1
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9615:SLC35A2
gene id: 9615:SLC35A2
uniprot id: Q8WMS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Interacts with SLC35A3; the interaction is reduced in the presence of SLC35A4 (By similarity). Found in a complex with SLC35A3 and SLC35A4 (By similarity).
messages: Transports uridine diphosphate galactose (UDP-galactose) from the cytosol into Golgi vesicles where glycosyltransferases function, including galactosyltransferases that catalyze globotriaosylceramide/globoside (Gb3Cer) synthesis from lactosylceramide.

9615:C20H19orf25
gene id: 9615:C20H19orf25
uniprot id: A0A8C0N795
uniprot id: A0A8I3NN05
names: Similarity
messages: Belongs to the UPF0449 family.

9615:IER5L
gene id: 9615:IER5L
uniprot id: A0A8C0MKQ4
names: Similarity
messages: Belongs to the IER family.

9615:SPI1
gene id: 9615:SPI1
uniprot id: A0A8C0QIT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:PRPF31
gene id: 9615:PRPF31
uniprot id: A0A8C0M5W5
uniprot id: A0A8I3MUP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

9615:GGA1
gene id: 9615:GGA1
uniprot id: A0A8C0S1V2
uniprot id: A0A8I3MXQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9615:BCL2L13
gene id: 9615:BCL2L13
uniprot id: A0A8C0PIS3
uniprot id: A0A8I3Q526
names: Similarity
messages: Belongs to the Bcl-2 family.

9615:CD79A
gene id: 9615:CD79A
uniprot id: P0CAN6
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).
messages: Cell membrane
messages: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-207, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity (By similarity).
messages: Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation (By similarity).
messages: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells (By similarity).

9615:RCVRN
gene id: 9615:RCVRN
uniprot id: Q8MIH6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity).
messages: Belongs to the recoverin family.
messages: EF-hand 2 and EF-hand 3 domains are the low-affinity and the high-affinity calcium binding sites, respectively. EF-hand 1 and EF-hand 4 domains do not bind calcium due to substitutions that disrupt their respective Ca(2+) binding loops. The cooperative binding of calcium to the EF-hand 2 domain following EF-hand 3 domain calcium binding requires myristoylation (By similarity). Calcium binding to the 2 EF-hand domains induces exposure of the myristoyl group through a protein conformation change, this process known as the calcium-myristoyl switch facilitates binding to photoreceptor cell membranes (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Homodimerization is caused by prolonged intense illumination (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts (via C-terminus) with GRK1 (via N-terminus); the interaction is Ca(2+)-dependent (By similarity).
messages: Oxidation on Cys-39 occurs in response to prolonged intense illumination and results in the formation of disulfide homodimers, and to a lesser extent disulfide-linked heterodimers.
messages: Perikaryon
messages: Photoreceptor inner segment
messages: Photoreceptor outer segment membrane
messages: The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present (By similarity). The Ca(2+) induced exposure of the myristoyl group, known as the calcium-myristoyl switch, promotes RCVRN binding to the photoreceptor cell membranes only when intracellular Ca(2+) concentration is high (By similarity).
messages: photoreceptor outer segment

9615:NDUFA3
gene id: 9615:NDUFA3
uniprot id: A0A8C0M2D5
uniprot id: A0A8I3MJP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9615:SULT4A1
gene id: 9615:SULT4A1
uniprot id: A0A8C0SDW5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:HCN3
gene id: 9615:HCN3
uniprot id: A0A8C0PLK4
uniprot id: A0A8P0SL85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9615:EHF
gene id: 9615:EHF
uniprot id: A0A8C0PG48
uniprot id: A0A8I3PMJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:NPM1
gene id: 9615:NPM1
uniprot id: A0A8C0PRY9
uniprot id: A0A8I3MEU8
names: Similarity
messages: Belongs to the nucleoplasmin family.

9615:GATA4
gene id: 9615:GATA4
uniprot id: Q0Q0E4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts (via the second Zn finger) with NFATC4 (By similarity). Interacts with LMCD1 (By similarity). Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with NR5A1, ZFPM2 and TBX5. Interacts with TBX18.
messages: Methylation at Lys-300 attenuates transcriptional activity.
messages: Nucleus
messages: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase.

9615:SCARB1
gene id: 9615:SCARB1
uniprot id: A0A8I3RZ34
names: Similarity
messages: Belongs to the CD36 family.

9615:BCO2
gene id: 9615:BCO2
uniprot id: A0A8P0TIU0
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9615:PABPC1
gene id: 9615:PABPC1
uniprot id: A0A8I3Q1H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9615:COCH
gene id: 9615:COCH
uniprot id: A0A8C0MZ00
uniprot id: A0A8I3NG47
names: Function
messages: Plays a role in the control of cell shape and motility in the trabecular meshwork.

9615:SMAD7
gene id: 9615:SMAD7
uniprot id: A0A8C0LW86
uniprot id: A0A8I3P368
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9615:PTGES3L
gene id: 9615:PTGES3L
uniprot id: A0A8P0TTU5
names: Similarity
messages: Belongs to the p23/wos2 family.

9615:SLC39A12
gene id: 9615:SLC39A12
uniprot id: A0A8C0N0D1
uniprot id: A0A8C0NE34
uniprot id: A0A8I3NMK0
uniprot id: A0A8I3P0B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9615:PRRX1
gene id: 9615:PRRX1
uniprot id: A0A8C0PWN6
uniprot id: A0A8C0R973
uniprot id: A0A8I3MZL1
uniprot id: A0A8I3RRN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9615:LOC100688441
gene id: 9615:LOC100688441
uniprot id: A0A8C0NTE3
uniprot id: A0A8I3PMR1
names: Similarity
messages: Belongs to the BEX family.

9615:CNR2
gene id: 9615:CNR2
uniprot id: A0A8C0PPU2
uniprot id: E2RKA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:LOC100856176
gene id: 9615:LOC100856176
uniprot id: A0A8C0QEG5
uniprot id: E2RD85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9615:S100PBP
gene id: 9615:S100PBP
uniprot id: A0A8C0NIF7
uniprot id: A0A8I3MT24
names: Subcellular Location Annotation
messages: Nucleus

9615:CYRIA
gene id: 9615:CYRIA
uniprot id: A0A8C0SA30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9615:HS6ST2
gene id: 9615:HS6ST2
uniprot id: A0A8C0THH1
uniprot id: A0A8C0TNC3
uniprot id: A0A8C0TNF6
uniprot id: A0A8I3Q6B0
uniprot id: A0A8I3S7Z0
uniprot id: A0A8P0SMU0
uniprot id: A0A8P0SN66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9615:NDUFB9
gene id: 9615:NDUFB9
uniprot id: A0A8P0N496
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:BOLA1
gene id: 9615:BOLA1
uniprot id: A0A8C0QH85
uniprot id: A0A8P0P591
names: Similarity
messages: Belongs to the BolA/IbaG family.

9615:ANKS4B
gene id: 9615:ANKS4B
uniprot id: A0A8C0MKZ6
uniprot id: A0A8I3MV48
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9615:SEC22A
gene id: 9615:SEC22A
uniprot id: A0A8C0TJN1
uniprot id: A0A8C0TNA5
uniprot id: A0A8I3PV59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9615:PARP8
gene id: 9615:PARP8
uniprot id: A0A8P0SY97
names: Similarity
messages: Belongs to the ARTD/PARP family.

9615:SEPTIN12
gene id: 9615:SEPTIN12
uniprot id: A0A8C0MFA1
uniprot id: A0A8I3P0Z9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9615:VIPAS39
gene id: 9615:VIPAS39
uniprot id: A0A8C0MH94
uniprot id: A0A8I3N7L9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9615:GTF2E2
gene id: 9615:GTF2E2
uniprot id: A0A8C0P9B0
uniprot id: A0A8C0PQ10
uniprot id: A0A8I3P0J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9615:PSMD2
gene id: 9615:PSMD2
uniprot id: A0A8C0TS00
uniprot id: A0A8P0SH90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9615:GPATCH11
gene id: 9615:GPATCH11
uniprot id: A0A8I3S0N0
names: Similarity
messages: Belongs to the GPATCH11 family.

9615:RPL15
gene id: 9615:RPL15
uniprot id: E2QXF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. Interacts with IFIT1 (via TPR repeats 1-4).
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9615:SERF1A
gene id: 9615:SERF1A
uniprot id: A0A8C0MBA1
uniprot id: A0A8I3NQ39
names: Similarity
messages: Belongs to the SERF family.

9615:DPY30
gene id: 9615:DPY30
uniprot id: A0A8C0SEN7
uniprot id: A0A8I3RX81
names: Similarity
messages: Belongs to the dpy-30 family.

9615:ARMC8
gene id: 9615:ARMC8
uniprot id: A0A8C0Z6B5
uniprot id: A0A8I3PUM8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:HYAL1
gene id: 9615:HYAL1
uniprot id: A0A8C0N5H8
uniprot id: A0A8I3PE17
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9615:TOMM22
gene id: 9615:TOMM22
uniprot id: A0A8C0NK70
uniprot id: A0A8I3S6N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9615:CKLF
gene id: 9615:CKLF
uniprot id: A0A8I3NK84
names: Subcellular Location Annotation
messages: Membrane

9615:OR7R1
gene id: 9615:OR7R1
uniprot id: A0A8C0TJL4
uniprot id: A0A8I3Q490
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:FKTN
gene id: 9615:FKTN
uniprot id: A0A8C0NI15
uniprot id: A0A8I3NIX6
names: Similarity
messages: Belongs to the LicD transferase family.

9615:CMAS
gene id: 9615:CMAS
uniprot id: A0A8I3NVQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

9615:EDNRB
gene id: 9615:EDNRB
uniprot id: P56497
uniprot id: Q9MYZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9615:MRPS18B
gene id: 9615:MRPS18B
uniprot id: A0A8C0YYK3
uniprot id: A0A8I3N171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

9615:KCNN3
gene id: 9615:KCNN3
uniprot id: A0A8C0RSK2
uniprot id: A0A8I3NVD3
names: Subcellular Location Annotation
messages: Membrane

9615:RPS24
gene id: 9615:RPS24
uniprot id: A0A8C0TRJ0
uniprot id: A0A8C0TTU5
uniprot id: A0A8C0TVV8
uniprot id: A0A8C0TW16
uniprot id: A0A8C0Z6H5
uniprot id: A0A8I3NSJ8
uniprot id: A0A8I3S0M2
uniprot id: H9GWG6
uniprot id: J9NRJ3
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9615:PPP1R14D
gene id: 9615:PPP1R14D
uniprot id: A0A8C0TTM2
uniprot id: A0A8I3PYP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9615:NOP2
gene id: 9615:NOP2
uniprot id: A0A8C0T457
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

9615:WBP4
gene id: 9615:WBP4
uniprot id: A0A8C0TEI8
uniprot id: A0A8I3NQF6
names: Subcellular Location Annotation
messages: Nucleus

9615:CLEC12B
gene id: 9615:CLEC12B
uniprot id: A0A8I3SAU5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:NCDN
gene id: 9615:NCDN
uniprot id: A0A8C0NN36
uniprot id: A0A8C0QDM1
uniprot id: A0A8I3P399
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

9615:RPL22L1
gene id: 9615:RPL22L1
uniprot id: A0A8C0YWJ8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9615:TCP1
gene id: 9615:TCP1
uniprot id: A0A8C0NFB2
uniprot id: A0A8I3MR56
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9615:DDX3X
gene id: 9615:DDX3X
uniprot id: A0A8C0YWQ4
uniprot id: A0A8P0P611
names: Similarity
messages: Belongs to the DEAD box helicase family.

9615:MDM2
gene id: 9615:MDM2
uniprot id: P56950
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autoubiquitination leads to proteasomal degradation; resulting in p53/TP53 activation it may be regulated by SFN. Also ubiquitinated by TRIM13. Deubiquitinated by USP2 leads to its accumulation and increases deubiquitination and degradation of p53/TP53. Deubiquitinated by USP7 leading to its stabilization.
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells. Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity).
messages: Interacts with p53/TP53, TP73/p73, RBL5 and RP11. Binds specifically to RNA. Can interact with RB1, E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with p53/TP53 and WWOX. Interacts with CDKN2AIP, RFWD3, USP7, PYHIN1 and RBBP6. Interacts with ARRB1 and ARRB2. Interacts with PSMA3. Found in a trimeric complex with MDM2, MDM4 and USP2. Interacts with USP2 (via N-terminus and C-terminus). Interacts with MDM4. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts directly with DAXX and USP7. Interacts (via C-terminus) with RASSF1 isoform A (via N-terminus); the interaction is independent of TP53. Interacts with APEX1; leading to its ubiquitination and degradation. Interacts with RYBP; this inhibits ubiquitination of TP53. Identified in a complex with RYBP and p53/TP53. Also a component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in regulating p53/TP53 stabilization and activity. Binds directly both p53/TP53 and TRIM28. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses with DNA damage. Interacts directly with both TRIM28 and ERBB4 in the complex. Interacts with DYRK2. Interacts with IGF1R. Interacts with TRIM13; the interaction ubiquitinates MDM2 leading to its proteasomal degradation. Interacts with SNAI1; this interaction promotes SNAI1 ubiquitination. Interacts with NOTCH1 (via intracellular domain). Interacts with FHIT. Interacts with RFFL and RNF34; the interaction stabilizes MDM2. Interacts with CDK5RAP3 and CDKN2A/ARF; form a ternary complex involved in regulation of p53/TP53. Interacts with MTA1. Interacts with AARB2. Interacts with MTBP. Interacts with PML. Interacts with RPL11. Interacts with TBRG1. Interacts with the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11; the interaction is direct occurs in the nucleoplasm and negatively regulates MDM2-mediated TP53 ubiquitination and degradation. Interacts with ADGRB1;…
messages: Isoform Mdm2-alpha is present in lymphoid and testicular tissues.
messages: Nucleus
messages: Phosphorylation on Ser-166 by SGK1 activates ubiquitination of p53/TP53. Phosphorylated at multiple sites near the RING domain by ATM upon DNA damage; this prevents oligomerization and E3 ligase processivity and impedes constitutive p53/TP53 degradation (By similarity).
messages: Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself (By similarity). Interacts with IGF1R (By similarity).
messages: nucleolus
messages: nucleoplasm

9615:HEATR5B
gene id: 9615:HEATR5B
uniprot id: A0A8P0SBG6
names: Similarity
messages: Belongs to the HEATR5 family.

9615:RAD50
gene id: 9615:RAD50
uniprot id: A0A8C0Q7A8
uniprot id: A0A8I3NID5
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9615:OR11G5
gene id: 9615:OR11G5
uniprot id: A0A8C0RGE1
uniprot id: A0A8P0P8I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ABCC2
gene id: 9615:ABCC2
uniprot id: Q9GK09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9615:MSTN
gene id: 9615:MSTN
uniprot id: Q6UKZ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted
messages: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

9615:SLC16A7
gene id: 9615:SLC16A7
uniprot id: A0A8C0T386
uniprot id: A0A8I3N8T1
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

9615:TUBB
gene id: 9615:TUBB
uniprot id: A0A8C0SSP9
uniprot id: A0A8I3N9K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:MCTS1
gene id: 9615:MCTS1
uniprot id: A0A8C0P1Z0
uniprot id: A0A8C0SW61
uniprot id: A0A8I3PN82
uniprot id: A0A8I3PNX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9615:MET
gene id: 9615:MET
uniprot id: Q75ZY9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells.
messages: (Microbial infection) Interacts with L.monocytogenes InlB (Probable). InlB probably dimerizes upon binding to MET, which encourages subsequent dimerization of MET (Probable).
messages: (Microbial infection) Tyrosine phosphorylation is stimulated by L.monocytogenes InlB.
messages: Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Membrane
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9615:ATP1B2
gene id: 9615:ATP1B2
uniprot id: A0A8C0NJN6
uniprot id: A0A8I3PRQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9615:SPDEF
gene id: 9615:SPDEF
uniprot id: A0A8C0MAB2
uniprot id: A0A8P0S761
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9615:FAM167B
gene id: 9615:FAM167B
uniprot id: A0A8P0NCN3
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9615:SHBG
gene id: 9615:SHBG
uniprot id: A0A8C0Q7C5
uniprot id: A0A8I3PLX4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CNOT11
gene id: 9615:CNOT11
uniprot id: A0A8C0SJP2
uniprot id: A0A8P0N597
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

9615:CHPT1
gene id: 9615:CHPT1
uniprot id: A0A8C0RHP3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9615:IL2RB
gene id: 9615:IL2RB
uniprot id: A0A8C0MT13
uniprot id: A0A8I3MVN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.

9615:CC2D1A
gene id: 9615:CC2D1A
uniprot id: A0A8P0NI15
names: Similarity
messages: Belongs to the CC2D1 family.

9615:C4H5orf22
gene id: 9615:C4H5orf22
uniprot id: A0A8I3MMH6
names: Similarity
messages: Belongs to the UPF0489 family.

9615:CCR9
gene id: 9615:CCR9
uniprot id: A0A8C0PWH9
uniprot id: E2RQ21
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:LPCAT2
gene id: 9615:LPCAT2
uniprot id: A0A8C0S2N3
uniprot id: A0A8I3MG02
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9615:RPS8
gene id: 9615:RPS8
uniprot id: A0A8C0NFR2
uniprot id: A0A8I3PPA9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

9615:PARL
gene id: 9615:PARL
uniprot id: A0A8C0N4K7
names: Subcellular Location Annotation
messages: Membrane

9615:RPS12
gene id: 9615:RPS12
uniprot id: A0A8C0SK69
uniprot id: A0A8I3RTT6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9615:NFE2L1
gene id: 9615:NFE2L1
uniprot id: A0A8I3NV45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. CNC subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9615:CPSF7
gene id: 9615:CPSF7
uniprot id: A0A8C0P4E9
uniprot id: A0A8C0Q849
uniprot id: A0A8C0QCQ3
uniprot id: A0A8I3NN63
uniprot id: A0A8I3RX51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9615:PPP4C
gene id: 9615:PPP4C
uniprot id: A0A8C0SWJ4
uniprot id: A0A8I3MJ81
names: Similarity
messages: Belongs to the PPP phosphatase family.

9615:ING3
gene id: 9615:ING3
uniprot id: A0A8C0NEW3
uniprot id: A0A8I3NFN6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9615:DDIT4L
gene id: 9615:DDIT4L
uniprot id: A0A8C0TEX6
names: Similarity
messages: Belongs to the DDIT4 family.

9615:FEZ1
gene id: 9615:FEZ1
uniprot id: A0A8C0N7Y3
uniprot id: A0A8I3RYE4
names: Similarity
messages: Belongs to the zygin family.

9615:SLC25A2
gene id: 9615:SLC25A2
uniprot id: A0A8C0QF53
uniprot id: A0A8I3RR57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:FOXO4
gene id: 9615:FOXO4
uniprot id: A0A8C0TRE3
names: Subcellular Location Annotation
messages: Nucleus

9615:ETS1
gene id: 9615:ETS1
uniprot id: A0A8C0MEX6
uniprot id: A0A8I3N088
uniprot id: A0A8I3N9R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9615:NDRG1
gene id: 9615:NDRG1
uniprot id: A0A8C0NZL8
uniprot id: L7V3M2
names: Similarity
messages: Belongs to the NDRG family.

9615:C3H15orf40
gene id: 9615:C3H15orf40
uniprot id: A0A8P0TKH1
names: Similarity
messages: Belongs to the UPF0235 family.

9615:ERN1
gene id: 9615:ERN1
uniprot id: A0A8P0NDV4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:UROD
gene id: 9615:UROD
uniprot id: A0A8C0T4X5
uniprot id: A0A8I3PMG0
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

9615:EDC3
gene id: 9615:EDC3
uniprot id: A0A8C0NAR2
uniprot id: A0A8I3Q712
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9615:STC2
gene id: 9615:STC2
uniprot id: A0A8C0RUF6
uniprot id: A0A8I3MD84
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9615:SIRT4
gene id: 9615:SIRT4
uniprot id: A0A8C0T8G6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

9615:TMEM170B
gene id: 9615:TMEM170B
uniprot id: A0A8C0SWU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9615:LOC478509
gene id: 9615:LOC478509
uniprot id: A0A5F4D4Q9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9615:LOC100684429
gene id: 9615:LOC100684429
uniprot id: A0A8I3PHH8
names: Similarity
messages: Belongs to the BEX family.

9615:TSPO
gene id: 9615:TSPO
uniprot id: A0A8C0M9V3
uniprot id: A0A8I3NSR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane
messages: Mitochondrion membrane

9615:GPHB5
gene id: 9615:GPHB5
uniprot id: A0A0F7RQS3
uniprot id: A0A8C0QC57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9615:KPNA1
gene id: 9615:KPNA1
uniprot id: A0A8C0TH72
uniprot id: A0A8I3PVT7
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9615:TAAR5
gene id: 9615:TAAR5
uniprot id: A0A8C0SKC5
uniprot id: D8KZR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9615:HCRT
gene id: 9615:HCRT
uniprot id: Q9GLF6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity).
messages: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity).
messages: Cytoplasmic vesicle
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
messages: Synapse

9615:IL1B
gene id: 9615:IL1B
uniprot id: A0A8C0M969
uniprot id: Q2VCE2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling. Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form. Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC. Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC.
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9615:TLX3
gene id: 9615:TLX3
uniprot id: A0A8C0PWJ0
names: Subcellular Location Annotation
messages: Nucleus

9615:PAN3
gene id: 9615:PAN3
uniprot id: A0A8I3PLB0
uniprot id: A0A8I3PNQ2
uniprot id: A0A8I3PQ88
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

9615:TLCD2
gene id: 9615:TLCD2
uniprot id: A0A8C0RWC8
uniprot id: A0A8I3NY16
names: Subcellular Location Annotation
messages: Membrane

9615:CDK5RAP3
gene id: 9615:CDK5RAP3
uniprot id: A0A8C0M3W4
uniprot id: A0A8I3P749
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9615:KPNA2
gene id: 9615:KPNA2
uniprot id: A0A8C0NGB8
uniprot id: A0A8I3PRA9
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9615:CFB
gene id: 9615:CFB
uniprot id: A0A8P0N3X6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:PODXL
gene id: 9615:PODXL
uniprot id: Q52S86
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the podocalyxin family.
messages: Expressed in glomerular and tubular epithelial cells and peritubular capillaries of the kidney (at protein level). Expressed in heart, lung, renal cortex and medulla, kidney and muscle.
messages: Found in a complex with EZR, PODXL and SLC9A3R2. Associates with the actin cytoskeleton through complex formation with EZR and SLC9A3R2. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R1 (via the PDZ domains); interaction is not detected in glomerular epithelium cells. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R2 (via the PDZ 1 domain); interaction is detected in glomerular epithelium cells. Interacts with EZR (By similarity). Monomer; when associated with the membrane raft. Oligomer; when integrated in the apical membrane. Interacts with SLC9A3R2. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R1 (via the PDZ domains); the interaction take place early in the secretory pathway and is necessary for its apical membrane sorting.
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
messages: Membrane
messages: Membrane raft
messages: N- and O-linked glycosylated. Sialoglycoprotein.
messages: The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis.
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

9615:DDB2
gene id: 9615:DDB2
uniprot id: A0A8C0S6B1
uniprot id: A0A8I3PWX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

9615:OSBPL8
gene id: 9615:OSBPL8
uniprot id: A0A8C0QBV1
uniprot id: A0A8I3RUP7
names: Similarity
messages: Belongs to the OSBP family.

9615:CLRN1
gene id: 9615:CLRN1
uniprot id: A0A8C0N1Z1
uniprot id: A0A8P0NAV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9615:COMP
gene id: 9615:COMP
uniprot id: A0A8C0TLZ8
uniprot id: A0A8I3P787
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PRKACB
gene id: 9615:PRKACB
uniprot id: A0A8C0NCS8
uniprot id: A0A8C0NGV3
uniprot id: A0A8C0RJS1
uniprot id: A0A8C0SLZ6
uniprot id: A0A8I3MHE8
uniprot id: A0A8I3MJG0
uniprot id: A0A8I3N0K1
uniprot id: A0A8I3N0M1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9615:PPP2CA
gene id: 9615:PPP2CA
uniprot id: Q8WN16
names: Similarity
messages: Belongs to the PPP phosphatase family.

9615:ID3
gene id: 9615:ID3
uniprot id: Q712G9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer, and heterodimer with other HLH proteins. Interacts with COPS5 and COPS7A. Interacts with IFI204. Interacts with GATA4 and NKX2-5. Interacts with ANKRD2; both proteins cooperate in myoblast differentiation. Interacts with CLOCK and BMAL1 (By similarity).
messages: Nucleus
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).

9615:FAS
gene id: 9615:FAS
uniprot id: A0A8I3Q9L2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

9615:MDH2
gene id: 9615:MDH2
uniprot id: A0A8C0MPI1
uniprot id: A0A8I3MS45
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

9615:RPL27
gene id: 9615:RPL27
uniprot id: A0A8C0RAK1
uniprot id: A0A8I3MYV4
uniprot id: Q9XSU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Component of the large ribosomal subunit (By similarity). Interacts with RRP1B (By similarity). Component of the large ribosomal subunit. Interacts with RRP1B. Interacts with DHX33 (By similarity).
messages: Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9615:CALU
gene id: 9615:CALU
uniprot id: A0A8C0MKA1
uniprot id: A0A8C0RFE4
uniprot id: A0A8I3PU96
uniprot id: A0A8P0T631
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

9615:NTSR2
gene id: 9615:NTSR2
uniprot id: A0A8I3PWE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:SLCO5A1
gene id: 9615:SLCO5A1
uniprot id: A0A8C0TJQ1
uniprot id: A0A8C0TKQ6
uniprot id: A0A8I3PP68
uniprot id: A0A8I3PTF0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:P2RX2
gene id: 9615:P2RX2
uniprot id: A0A8P0NZC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9615:IPO13
gene id: 9615:IPO13
uniprot id: A0A8C0NC47
uniprot id: A0A8I3Q0B0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9615:RAD23B
gene id: 9615:RAD23B
uniprot id: A0A8C0NDB8
uniprot id: A0A8P0S8J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9615:LOC102155886
gene id: 9615:LOC102155886
uniprot id: A0A8C0TJW1
uniprot id: A0A8I3NS12
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9615:TMEM115
gene id: 9615:TMEM115
uniprot id: A0A8C0SPZ8
names: Subcellular Location Annotation
messages: Membrane

9615:CDR2L
gene id: 9615:CDR2L
uniprot id: A0A8C0N7J0
uniprot id: A0A8C0N7L9
uniprot id: A0A8P0P5E1
uniprot id: A0A8P0SW45
names: Similarity
messages: Belongs to the CDR2 family.

9615:BEST2
gene id: 9615:BEST2
uniprot id: A0A8C0NUH7
uniprot id: A0A8I3RZ58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9615:NDUFAB1
gene id: 9615:NDUFAB1
uniprot id: A0A8C0Q1C6
uniprot id: A0A8I3MJL3
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9615:LOC102155828
gene id: 9615:LOC102155828
uniprot id: A0A8I3P0M0
names: Similarity
messages: Belongs to the MS4A family.

9615:OR6C2F
gene id: 9615:OR6C2F
uniprot id: G3FJE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MCF2L
gene id: 9615:MCF2L
uniprot id: A0A8P0P5J5
uniprot id: A0A8P0SBT3
uniprot id: A0A8P0T895
names: Subcellular Location Annotation
messages: Cytoplasm

9615:TOP3B
gene id: 9615:TOP3B
uniprot id: A0A8C0TLE8
uniprot id: A0A8I3PSZ4
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9615:STX12
gene id: 9615:STX12
uniprot id: A0A8C0RHL7
uniprot id: A0A8I3NIZ9
names: Similarity
messages: Belongs to the syntaxin family.

9615:PERP
gene id: 9615:PERP
uniprot id: A0A8C0RVL1
uniprot id: A0A8I3N282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9615:SEMA4F
gene id: 9615:SEMA4F
uniprot id: A0A8C0QBD4
uniprot id: A0A8C0QBJ9
uniprot id: A0A8I3NZS3
uniprot id: A0A8I3P073
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:H2AZ2
gene id: 9615:H2AZ2
uniprot id: A0A8C0MLN7
uniprot id: A0A8C0TN40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:OR6AA6
gene id: 9615:OR6AA6
uniprot id: A0A8C0LW02
uniprot id: G3FJC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MDM4
gene id: 9615:MDM4
uniprot id: A0A8C0SPP9
uniprot id: A0A8I3PE84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

9615:NAGK
gene id: 9615:NAGK
uniprot id: A0A8I3P9K5
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9615:TNPO2
gene id: 9615:TNPO2
uniprot id: A0A8C0RPA0
uniprot id: A0A8C0TNZ4
uniprot id: A0A8I3S253
names: Subcellular Location Annotation
messages: Cytoplasm

9615:SHOX2
gene id: 9615:SHOX2
uniprot id: A0A8C0TCP5
uniprot id: A0A8I3PLZ7
names: Subcellular Location Annotation
messages: Nucleus

9615:RBKS
gene id: 9615:RBKS
uniprot id: A0A8C0SJV6
uniprot id: A0A8I3NFL0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9615:UGP2
gene id: 9615:UGP2
uniprot id: A0A8C0Q2E5
uniprot id: A0A8I3S420
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9615:SLC10A6
gene id: 9615:SLC10A6
uniprot id: A0A8C0REE4
uniprot id: A0A8I3PJ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9615:B4GAT1
gene id: 9615:B4GAT1
uniprot id: A0A8C0RM78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:PON1
gene id: 9615:PON1
uniprot id: A0A8C0NUH5
uniprot id: A0A8I3PDF6
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9615:RECQL
gene id: 9615:RECQL
uniprot id: A0A8C0TTS5
uniprot id: A0A8I3NQI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9615:TAS1R3
gene id: 9615:TAS1R3
uniprot id: Q49HH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
messages: Cell membrane
messages: Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
messages: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity).

9615:NKX6-1
gene id: 9615:NKX6-1
uniprot id: A0A8C0MX83
uniprot id: A0A8I3PA23
names: Subcellular Location Annotation
messages: Nucleus

9615:TMC5
gene id: 9615:TMC5
uniprot id: A0A8C0NXE6
uniprot id: A0A8C0Q0G1
uniprot id: A0A8I3N854
uniprot id: A0A8I3NCG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9615:PCMTD2
gene id: 9615:PCMTD2
uniprot id: A0A8C0PDE8
uniprot id: A0A8I3PQA4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9615:TFEB
gene id: 9615:TFEB
uniprot id: A0A8C0MCF3
uniprot id: A0A8I3NYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9615:DHDH
gene id: 9615:DHDH
uniprot id: Q9TV68
names: Activity Regulation
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the Gfo/Idh/MocA family.
messages: Homodimer.
messages: Liver and kidney.
messages: Strongly inhibited by isoascorbic acid, 4-hydroxyacetophenone and 4-chloromercuriphenylsulphonate. Stimulated by various salts.

9615:CYFIP2
gene id: 9615:CYFIP2
uniprot id: A0A8C0MWY8
names: Similarity
messages: Belongs to the CYFIP family.

9615:ANO10
gene id: 9615:ANO10
uniprot id: A0A8C0P8I2
uniprot id: A0A8C0Q316
uniprot id: A0A8P0NTS5
uniprot id: A0A8P0SA54
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:PNRC1
gene id: 9615:PNRC1
uniprot id: A0A8C0RIH6
uniprot id: A0A8P0NP00
names: Subcellular Location Annotation
messages: Nucleus

9615:RAE1
gene id: 9615:RAE1
uniprot id: A0A8C0PMX3
uniprot id: A0A8I3Q4R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat rae1 family.
messages: spindle pole

9615:RAB3IL1
gene id: 9615:RAB3IL1
uniprot id: A0A8P0P009
uniprot id: A0A8P0PE16
uniprot id: A0A8P0SK89
uniprot id: A0A8P0TC97
names: Similarity
messages: Belongs to the SEC2 family.

9615:MAGOH
gene id: 9615:MAGOH
uniprot id: A0A8C0RCD0
uniprot id: A0A8I3P1R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9615:GNAL
gene id: 9615:GNAL
uniprot id: A0A8C0S278
uniprot id: A0A8I3RTU2
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9615:CFAP52
gene id: 9615:CFAP52
uniprot id: A0A8C0YYL8
uniprot id: A0A8I3MPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP52 family.
messages: cilium axoneme
messages: flagellum

9615:PSMC5
gene id: 9615:PSMC5
uniprot id: A0A8C0Z0G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9615:LOC100855683
gene id: 9615:LOC100855683
uniprot id: A0A8C0M657
uniprot id: A0A8I3NI34
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.

9615:PTGIR
gene id: 9615:PTGIR
uniprot id: A0A8I3MUB8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:GOLPH3L
gene id: 9615:GOLPH3L
uniprot id: A0A8C0S9G5
uniprot id: A0A8I3NX17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9615:RPL13A
gene id: 9615:RPL13A
uniprot id: A0A8C0T1U3
uniprot id: A0A8I3PH30
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9615:MRPS12
gene id: 9615:MRPS12
uniprot id: A0A8C0NM32
uniprot id: A0A8I3MM58
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9615:ING1
gene id: 9615:ING1
uniprot id: A0A8C0PI87
uniprot id: A0A8I3PA68
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9615:MOCS3
gene id: 9615:MOCS3
uniprot id: A0A8P0NDQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

9615:ACKR2
gene id: 9615:ACKR2
uniprot id: A0A8C0SXU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9615:ZFP36L1
gene id: 9615:ZFP36L1
uniprot id: A0A8C0SGM8
uniprot id: A0A8I3MS54
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9615:CPNE7
gene id: 9615:CPNE7
uniprot id: A0A8I3MMK8
uniprot id: F1P6M8
names: Similarity
messages: Belongs to the copine family.

9615:RCAN2
gene id: 9615:RCAN2
uniprot id: A0A8C0MK86
uniprot id: A0A8I3NHX7
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9615:H1-1
gene id: 9615:H1-1
uniprot id: A0A8I3Q6R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9615:SRPRB
gene id: 9615:SRPRB
uniprot id: A0A8C0MVG1
uniprot id: A0A8I3Q3L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:JAGN1
gene id: 9615:JAGN1
uniprot id: A0A8C0TN08
uniprot id: A0A8I3N524
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:DONSON
gene id: 9615:DONSON
uniprot id: A0A8C0MPA1
uniprot id: A0A8I3PLX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

9615:TULP3
gene id: 9615:TULP3
uniprot id: A0A8C0PHH4
uniprot id: A0A8P0NGY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9615:CENPN
gene id: 9615:CENPN
uniprot id: A0A8C0M0L7
uniprot id: A0A8I3PED2
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9615:LOC491788
gene id: 9615:LOC491788
uniprot id: A0A8C0NRZ0
uniprot id: A0A8I3S7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9615:EML2
gene id: 9615:EML2
uniprot id: A0A8C0M3Q0
uniprot id: A0A8C0RBX1
uniprot id: A0A8I3MMZ7
uniprot id: A0A8I3MVN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9615:ANKLE2
gene id: 9615:ANKLE2
uniprot id: A0A8C0SXR9
uniprot id: A0A8C0SZI7
uniprot id: A0A8I3S9N7
names: Similarity
messages: Belongs to the ANKLE2 family.

9615:CIAO3
gene id: 9615:CIAO3
uniprot id: A0A8C0NA02
names: Similarity
messages: Belongs to the NARF family.

9615:LOC485909
gene id: 9615:LOC485909
uniprot id: A0A8C0QH22
uniprot id: A0A8I3P8S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9615:SFTPD
gene id: 9615:SFTPD
uniprot id: A0A8C0LX87
uniprot id: A0A8I3NUR4
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

9615:SCN5A
gene id: 9615:SCN5A
uniprot id: Q865W3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9615:PGGT1B
gene id: 9615:PGGT1B
uniprot id: A0A8C0MAV6
uniprot id: A0A8I3NU24
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9615:CLUL1
gene id: 9615:CLUL1
uniprot id: Q95KN1
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the clusterin family.
messages: Retina-specific (at protein level). In the light-adapted retina, expressed in the outer segment of cone photoreceptors. In the dark-adapted retina, strongly expressed in the outer plexiform layer in the region of contact between the cone pedicles and second order neurons with little or no expression in the cone photoreceptor outer segments.
messages: Secreted

9615:ING2
gene id: 9615:ING2
uniprot id: A0A8C0NI99
uniprot id: A0A8I3NQF3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9615:IL1R1
gene id: 9615:IL1R1
uniprot id: A0A8C0QF36
uniprot id: A0A8C0QLC9
uniprot id: A0A8I3NH34
uniprot id: A0A8I3RY59
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9615:PSMB7
gene id: 9615:PSMB7
uniprot id: E7BUQ0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9615:GORASP2
gene id: 9615:GORASP2
uniprot id: A0A8C0N2V7
uniprot id: A0A8I3SA28
names: Similarity
messages: Belongs to the GORASP family.

9615:IFNK
gene id: 9615:IFNK
uniprot id: A0A8C0Q5M1
uniprot id: E2RHB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9615:PNRC2
gene id: 9615:PNRC2
uniprot id: A0A8I3NU81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Nucleus
messages: P-body

9615:HMGB3
gene id: 9615:HMGB3
uniprot id: A0A8C0SUV1
uniprot id: A0A8I3PS14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9615:LYPD2
gene id: 9615:LYPD2
uniprot id: A0A8I3NVD7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:MADD
gene id: 9615:MADD
uniprot id: A0A8C0PII1
uniprot id: A0A8C0PK04
uniprot id: A0A8I3PFN7
uniprot id: A0A8I3PLS9
uniprot id: A0A8I3PRU0
uniprot id: A0A8I3S3R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9615:TUT7
gene id: 9615:TUT7
uniprot id: A0A8C0PL51
uniprot id: A0A8C0PND6
uniprot id: A0A8C0PUX5
uniprot id: A0A8C0PV02
uniprot id: A0A8I3MWU8
uniprot id: A0A8I3MZI3
uniprot id: A0A8I3NAY0
uniprot id: A0A8I3RTZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

9615:FCN2
gene id: 9615:FCN2
uniprot id: A0A8C0PRX5
uniprot id: A0A8I3NLF4
names: Similarity
messages: Belongs to the ficolin lectin family.

9615:FAM174A
gene id: 9615:FAM174A
uniprot id: A0A8C0SMD7
uniprot id: A0A8I3MK74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9615:ARHGEF2
gene id: 9615:ARHGEF2
uniprot id: Q865S3
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Involved in neuronal progenitor cell division and differentiation. Involved in the migration of precerebellar neurons (By similarity). Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (PubMed:12604587).
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Interacts with YWHAZ/14-3-3 zeta; when phosphorylated at Ser-886. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1. Interacts (via the N- terminal zinc finger) with CAPN6 (via domain II). Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3 (By similarity). Interacts with DYNLT1.
messages: Phosphorylation of Ser-886 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner (By similarity).
messages: The DH (DBL-homology) domain promotes tyrosine phosphorylation of RIPK2 (By similarity). The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA.
messages: The PH domain has no affinity for phosphoinositides suggesting that it does not interact directly with membranes.
messages: The phorbol-ester/DAG-type zinc-finger and the C-terminal coiled-coil domains (606-986) are both important for association with microtubules.
messages: cytoskeleton
messages: spindle
messages: tight junction

9615:NDUFB10
gene id: 9615:NDUFB10
uniprot id: A0A8C0NYV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

9615:LOC475395
gene id: 9615:LOC475395
uniprot id: A0A8C0MFN1
uniprot id: W0UTI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9615:SEPHS1
gene id: 9615:SEPHS1
uniprot id: A0A8C0NIV4
uniprot id: A0A8I3RZH4
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9615:AKR1C3
gene id: 9615:AKR1C3
uniprot id: A0A8C0LYD8
uniprot id: Q5FYA7
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9615:RAB27A
gene id: 9615:RAB27A
uniprot id: Q1HE58
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5. Interacts with RPH3A and RPH3A (By similarity). Binds MLPH and SYTL2. Interacts with UNC13D. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (By similarity). Interacts (GDP-bound form preferentially) with DENND10 (By similarity).
messages: Late endosome
messages: Lysosome
messages: Melanosome
messages: Membrane
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as DENND10.
messages: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

9615:POU2F1
gene id: 9615:POU2F1
uniprot id: A0A8C0P843
uniprot id: A0A8C0PCZ0
uniprot id: A0A8I3MPV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9615:RPL24
gene id: 9615:RPL24
uniprot id: A0A8C0NRA6
uniprot id: A0A8I3PBR3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9615:MRPL50
gene id: 9615:MRPL50
uniprot id: A0A8C0RZV8
uniprot id: A0A8I3N0A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9615:PEBP1
gene id: 9615:PEBP1
uniprot id: Q3YIX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylethanolamine-binding protein family.
messages: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Involved in the positive regulation of epithelial cell migration. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).
messages: Cytoplasm
messages: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
messages: Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade (By similarity).

9615:HSD17B3
gene id: 9615:HSD17B3
uniprot id: A0A8C0MSR5
uniprot id: A0A8C0Q1B2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:CAPZA2
gene id: 9615:CAPZA2
uniprot id: A0M8V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity).

9615:DERL2
gene id: 9615:DERL2
uniprot id: A0A8C0P194
uniprot id: A0A8I3MTN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:MRPS18A
gene id: 9615:MRPS18A
uniprot id: A0A8C0S1X4
uniprot id: A0A8I3N5L6
names: Subcellular Location Annotation
messages: Mitochondrion

9615:PCNP
gene id: 9615:PCNP
uniprot id: A0A8I3PAS2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

9615:CFL1
gene id: 9615:CFL1
uniprot id: A0A8C0NGL0
uniprot id: A0A8I3P3F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: lamellipodium membrane
messages: ruffle membrane

9615:PDK2
gene id: 9615:PDK2
uniprot id: A0A8C0R9P9
uniprot id: A0A8I3NK58
uniprot id: A0A8P0NIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9615:GAA
gene id: 9615:GAA
uniprot id: A0A8I3S046
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:VEGFA
gene id: 9615:VEGFA
uniprot id: Q9MYV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (By similarity). Interacts with BSG (By similarity).
messages: Secreted

9615:FCGRT
gene id: 9615:FCGRT
uniprot id: A0A8C0SWK8
uniprot id: A0A8I3PFR8
names: Similarity
messages: Belongs to the MHC class I family.

9615:TM9SF1
gene id: 9615:TM9SF1
uniprot id: A0A8C0Q6B9
uniprot id: A0A8P0SGS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9615:REEP4
gene id: 9615:REEP4
uniprot id: A0A8C0NMU1
uniprot id: A0A8I3PSS0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ADGRG3
gene id: 9615:ADGRG3
uniprot id: A0A8C0S6C9
uniprot id: A0A8I3N3J7
names: Subcellular Location Annotation
messages: Membrane

9615:PLSCR4
gene id: 9615:PLSCR4
uniprot id: A0A8C0MLH3
uniprot id: A0A8I3P9T2
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9615:PRDX2
gene id: 9615:PRDX2
uniprot id: A0A8C0Z5S7
uniprot id: A0A8I3NZ15
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9615:IRX6
gene id: 9615:IRX6
uniprot id: A0A8C0RDW5
uniprot id: A0A8P0SED9
names: Subcellular Location Annotation
messages: Nucleus

9615:ZNF706
gene id: 9615:ZNF706
uniprot id: A0A8C0NSV7
uniprot id: A0A8I3PZJ0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:REV3L
gene id: 9615:REV3L
uniprot id: A0A8C0MFV9
uniprot id: A0A8C0S252
uniprot id: A0A8I3P310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9615:GPLD1
gene id: 9615:GPLD1
uniprot id: A0A8P0PCS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

9615:APOH
gene id: 9615:APOH
uniprot id: P33703
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Expressed by the liver and secreted in plasma.
messages: Secreted

9615:NRN1
gene id: 9615:NRN1
uniprot id: A0A8C0YX63
uniprot id: A0A8I3P2X9
names: Similarity
messages: Belongs to the neuritin family.

9615:PAX8
gene id: 9615:PAX8
uniprot id: P47240
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with WWTR1.
messages: Nucleus
messages: Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.

9615:ARMC1
gene id: 9615:ARMC1
uniprot id: A0A8C0T7P4
uniprot id: A0A8I3S2W4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9615:ARHGEF11
gene id: 9615:ARHGEF11
uniprot id: A0A8I3NUB9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9615:SEMA4D
gene id: 9615:SEMA4D
uniprot id: A0A8P0NZW3
uniprot id: A0A8P0PAW9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TNF
gene id: 9615:TNF
uniprot id: A9LMQ0
uniprot id: P51742
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9615:GTF2H3
gene id: 9615:GTF2H3
uniprot id: A0A8C0TNI3
uniprot id: A0A8I3P3S7
uniprot id: A0A8I3P9S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9615:CPEB4
gene id: 9615:CPEB4
uniprot id: A0A8C0LXN5
uniprot id: A0A8C0M2T2
uniprot id: A0A8C0M321
uniprot id: A0A8P0NIB0
uniprot id: A0A8P0P4I3
uniprot id: A0A8P0PCZ1
names: Similarity
messages: Belongs to the RRM CPEB family.

9615:NMNAT2
gene id: 9615:NMNAT2
uniprot id: A0A8C0PVZ1
uniprot id: A0A8I3MTZ8
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9615:IRF8
gene id: 9615:IRF8
uniprot id: A0A8I3MVZ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:RFX3
gene id: 9615:RFX3
uniprot id: A0A8C0Q5D7
uniprot id: A0A8I3MU48
names: Subcellular Location Annotation
messages: Nucleus

9615:LRRC8A
gene id: 9615:LRRC8A
uniprot id: A0A8C0MGY0
uniprot id: A0A8I3PQW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9615:CKS1B
gene id: 9615:CKS1B
uniprot id: A0A8C0PBD3
uniprot id: A0A8I3S0K0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9615:GPR31
gene id: 9615:GPR31
uniprot id: A0A8C0PS74
uniprot id: A0A8I3MVK0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:NUDT17
gene id: 9615:NUDT17
uniprot id: A0A8I3RY69
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

9615:DDI1
gene id: 9615:DDI1
uniprot id: A0A8C0SQA6
uniprot id: A0A8P0SQ39
names: Similarity
messages: Belongs to the DDI1 family.

9615:GPM6B
gene id: 9615:GPM6B
uniprot id: A0A8C0RPC5
uniprot id: A0A8C0RPH1
uniprot id: A0A8C0SCF8
uniprot id: A0A8C0YWP6
uniprot id: A0A8I3QRI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9615:TMEM126A
gene id: 9615:TMEM126A
uniprot id: A0A8C0MQU2
uniprot id: A0A8I3N8M5
names: Subcellular Location Annotation
messages: Membrane

9615:SLC51A
gene id: 9615:SLC51A
uniprot id: A0A8C0TUF0
uniprot id: A0A8I3Q2C1
names: Subcellular Location Annotation
messages: Membrane

9615:METTL4
gene id: 9615:METTL4
uniprot id: A0A8P0SML7
names: Similarity
messages: Belongs to the MT-A70-like family.

9615:MTX2
gene id: 9615:MTX2
uniprot id: A0A8C0RPQ8
uniprot id: A0A8I3NYI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:AKR1B1
gene id: 9615:AKR1B1
uniprot id: A0A8C0RIR1
uniprot id: A0A8I3P2L6
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9615:SPX
gene id: 9615:SPX
uniprot id: A0A8C0PBI6
uniprot id: A0A8I3S146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

9615:RYR1
gene id: 9615:RYR1
uniprot id: A0A8I3RU53
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9615:TP53I11
gene id: 9615:TP53I11
uniprot id: A0A8C0PCS4
uniprot id: A0A8I3N2A4
names: Subcellular Location Annotation
messages: Membrane

9615:LOC100685565
gene id: 9615:LOC100685565
uniprot id: A0A8C0TUR6
uniprot id: A0A8P0SBV4
names: Similarity
messages: Belongs to the TTC39 family.

9615:FSCN1
gene id: 9615:FSCN1
uniprot id: A0A8I3NPK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9615:SPC24
gene id: 9615:SPC24
uniprot id: A0A8C0Z0C5
uniprot id: A0A8I3PG90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9615:NDUFA13
gene id: 9615:NDUFA13
uniprot id: A0A8C0RIQ0
uniprot id: A0A8I3NVS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

9615:HADH
gene id: 9615:HADH
uniprot id: A0A8P0TBX0
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9615:IKBKE
gene id: 9615:IKBKE
uniprot id: A0A8P0T6W4
uniprot id: A0A8P0TEM4
names: Subcellular Location Annotation
messages: Cytoplasm

9615:LIG3
gene id: 9615:LIG3
uniprot id: A0A8C0NM77
uniprot id: A0A8C0S6S7
uniprot id: A0A8C0S7L5
uniprot id: A0A8I3N6P7
uniprot id: A0A8I3N6S7
uniprot id: A0A8I3N6V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9615:AURKB
gene id: 9615:AURKB
uniprot id: A0A8C0NZ38
uniprot id: A0A8C0QQK2
uniprot id: A0A8I3Q4W5
uniprot id: A0A8I3QG95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centromere

9615:BUD31
gene id: 9615:BUD31
uniprot id: A0A8C0NK50
uniprot id: A0A8I3MQ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9615:LOC100685822
gene id: 9615:LOC100685822
uniprot id: A0A8P0NR06
names: Subcellular Location Annotation
messages: Nucleus

9615:BIRC5
gene id: 9615:BIRC5
uniprot id: Q8I009
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.
messages: Belongs to the IAP family.
messages: Chromosome
messages: Cytoplasm
messages: In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity. Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis.
messages: Midbody
messages: Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8. Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce. Interacts with FBXL7; this interaction facilitates the polyubiquitination and subsequent proteasomal degradation of BIRC5 by the SCF(FBXL7) E3 ubiquitin-protein ligase complex (By similarity).
messages: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity).
messages: Nucleus
messages: The BIR repeat is necessary and sufficient for LAMTOR5 binding.
messages: Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.
messages: centromere
messages: kinetochore
messages: spindle

9615:DSG2
gene id: 9615:DSG2
uniprot id: A0A8C0SFV3
uniprot id: A0A8I3RY38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9615:OR4D9B
gene id: 9615:OR4D9B
uniprot id: A0A8I3P7S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:DAO
gene id: 9615:DAO
uniprot id: A0A8C0THP9
uniprot id: A0A8P0NDF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9615:SGCA
gene id: 9615:SGCA
uniprot id: A0A8C0SAC5
uniprot id: A0A8I3RZD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton

9615:DEFB122
gene id: 9615:DEFB122
uniprot id: Q30KT2
uniprot id: Q863C8
uniprot id: Q863D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:FAM110D
gene id: 9615:FAM110D
uniprot id: A0A8C0NIS4
uniprot id: A0A8P0NEC7
names: Similarity
messages: Belongs to the FAM110 family.

9615:MRPL37
gene id: 9615:MRPL37
uniprot id: A0A8C0M7G9
uniprot id: A0A8I3NQP4
names: Subcellular Location Annotation
messages: Mitochondrion

9615:APOC2
gene id: 9615:APOC2
uniprot id: P12278
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.
messages: Highly expressed in the liver. Moderately expressed in the ileum, jejunum and ovary.
messages: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
messages: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
messages: Secreted

9615:IL15
gene id: 9615:IL15
uniprot id: A0A8C0NA66
uniprot id: A0A8P0S9D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9615:KRTAP3-1
gene id: 9615:KRTAP3-1
uniprot id: A0A8C0NNH8
uniprot id: A0A8I3NQB8
names: Similarity
messages: Belongs to the KRTAP type 3 family.

9615:AXIN2
gene id: 9615:AXIN2
uniprot id: A0A8P0ND93
names: Subcellular Location Annotation
messages: Cytoplasm

9615:PDHB
gene id: 9615:PDHB
uniprot id: A0A8C0QIK1
uniprot id: A0A8I3S3U9
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9615:GHITM
gene id: 9615:GHITM
uniprot id: A0A8C0M0G3
uniprot id: A0A8I3MY76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9615:CDH2
gene id: 9615:CDH2
uniprot id: A0A8C0SNQ2
uniprot id: A0A8P0T6R4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Cell surface
messages: Membrane
messages: sarcolemma

9615:ARG2
gene id: 9615:ARG2
uniprot id: A0A8C0SB48
uniprot id: A0A8I3MI74
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9615:CAP2
gene id: 9615:CAP2
uniprot id: A0A8I3PTG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane

9615:BMS1
gene id: 9615:BMS1
uniprot id: A0A8P0SCF9
names: Subcellular Location Annotation
messages: nucleolus

9615:SHCBP1
gene id: 9615:SHCBP1
uniprot id: A0A8C0S4I3
uniprot id: A0A8I3NXW0
names: Subcellular Location Annotation
messages: spindle

9615:NDUFA8
gene id: 9615:NDUFA8
uniprot id: A0A8C0Q1A4
uniprot id: A0A8I3P1K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9615:NCBP3
gene id: 9615:NCBP3
uniprot id: A0A8C0MSZ4
uniprot id: A0A8I3RZM9
uniprot id: A0A8I3S2H3
names: Similarity
messages: Belongs to the NCBP3 family.

9615:CXXC5
gene id: 9615:CXXC5
uniprot id: A0A8I3MH47
names: Subcellular Location Annotation
messages: Cytoplasm

9615:ADCY5
gene id: 9615:ADCY5
uniprot id: P30803
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by forskolin (PubMed:1618857, PubMed:8428899). Activated by GNAS. Activity is further increased by interaction with the G-protein beta and gamma subunit complex formed by GNB1 and GNG2 (By similarity). Is not activated by calmodulin. Inhibited by adenosine and ATP analogs. Inhibited by calcium ions, already at micromolar concentrations (PubMed:1618857). Phosphorylation by RAF1 results in its activation (By similarity).
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit (PubMed:16766715, PubMed:19243146). Is also active with manganese (in vitro) (PubMed:11087399, PubMed:16766715).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:1618857, PubMed:8428899, PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity).
messages: Cell membrane
messages: Interacts with GNAS (PubMed:9417641, PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). Interacts with GNB1 and GNG2 (By similarity). Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1 (By similarity).
messages: Isoform 1 is detected in heart, and at lower levels in brain (PubMed:1618857). Isoform 2 is detected in heart (PubMed:8428899).
messages: Lacks catalytic activity by itself, but can associate with isoform 1 to form active adenylyl cyclase.
messages: The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
messages: cilium

9615:TLCD3A
gene id: 9615:TLCD3A
uniprot id: A0A8C0NRQ6
uniprot id: A0A8I3NT92
names: Subcellular Location Annotation
messages: Membrane

9615:CTSF
gene id: 9615:CTSF
uniprot id: A0A8I3NPI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9615:BEX4
gene id: 9615:BEX4
uniprot id: A0A8C0REE8
names: Similarity
messages: Belongs to the BEX family.

9615:AP2A1
gene id: 9615:AP2A1
uniprot id: A0A8C0LU67
uniprot id: A0A8C0M3V6
uniprot id: A0A8I3S2R3
uniprot id: A0A8I3S565
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9615:ABI1
gene id: 9615:ABI1
uniprot id: A0A8C0N970
uniprot id: A0A8C0NDR2
uniprot id: A0A8C0PVE0
uniprot id: A0A8I3ML42
uniprot id: A0A8I3MRK3
uniprot id: A0A8I3MTR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9615:LOC100855430
gene id: 9615:LOC100855430
uniprot id: A0A8C0P6T5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9615:SIRT3
gene id: 9615:SIRT3
uniprot id: A0A8P0NYF7
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: NAD-dependent protein deacetylase.

9615:AARS2
gene id: 9615:AARS2
uniprot id: A0A8C0SB15
uniprot id: A0A8I3NJ93
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9615:COPZ1
gene id: 9615:COPZ1
uniprot id: A0A8C0RTX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9615:LOC102152612
gene id: 9615:LOC102152612
uniprot id: A0A8C0Q9N4
uniprot id: A0A8I3MY97
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9615:HAO2
gene id: 9615:HAO2
uniprot id: A0A8C0MFB5
uniprot id: A0A8I3MYD4
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9615:UBQLN1
gene id: 9615:UBQLN1
uniprot id: A0A8C0PPH9
uniprot id: A0A8C0PY02
uniprot id: A0A8P0T1P3
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9615:CCR5
gene id: 9615:CCR5
uniprot id: Q5ECR9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis.
messages: O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
messages: Palmitoylation in the C-terminal is important for cell surface expression.
messages: Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (PubMed:16806494). Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (By similarity) (PubMed:16806494).
messages: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity).

9615:OR52J8
gene id: 9615:OR52J8
uniprot id: A0A8C0TLA3
uniprot id: A0A8I3NYI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SLC6A12
gene id: 9615:SLC6A12
uniprot id: P27799
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Interacts with LIN7C.
messages: Kidney.
messages: Membrane
messages: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.

9615:ARSK
gene id: 9615:ARSK
uniprot id: Q32KH0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity).
messages: Lysosome
messages: N-glycosylated with both high mannose and complex type sugars.
messages: Secreted
messages: The 75-kDa precursor undergoes proteolytic processing to yield a 23 kDa form.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9615:VPS37A
gene id: 9615:VPS37A
uniprot id: A0A8C0P2Z0
uniprot id: A0A8I3RY92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9615:ELN
gene id: 9615:ELN
uniprot id: A0A8I3MRF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elastin family.
messages: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle.
messages: extracellular matrix

9615:RPS3
gene id: 9615:RPS3
uniprot id: E2RH47
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the 40S small ribosomal subunit. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with HNRPD. Interacts with PRMT1; the interaction methylates RPS3. Interacts with SUMO1; the interaction sumoylates RPS3. Interacts with UBC9. Interacts with CDK1; the interaction phosphorylates RPS3. Interacts with PRKCD; the interaction phosphorylates RPS3. Interacts with PKB/AKT; the interaction phosphorylates RPS3. Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity. Interacts with UNG; the interaction increases the uracil excision activity of UNG1. Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels. Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion. Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex. Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA. Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus. Interacts (via KH domain) with MDM2 and TP53. Interacts with TRADD. Interacts with CRY1.
messages: Cytoplasm
messages: Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiester backbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes. Represses its own translation by binding to its cognate mRNA. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization. Involved in induction of apoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation.
messages: Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.
messages: Mitochondrion inner membrane
messages: Nucleus
messages: Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase. Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity. Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3. Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide. Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis.
messages: Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.
messages: Ubiquitinated. This is prevented by interaction with HSP90 which stabilizes the protein. Monoubiquitinated at Lys-214 by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide.
messages: Ufmylated by UFL1.
messages: nucleolus
messages: spindle

9615:CHRNA6
gene id: 9615:CHRNA6
uniprot id: A0A8C0Q1H7
uniprot id: A0A8P0SAX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:ADAM23
gene id: 9615:ADAM23
uniprot id: A0A8P0T6A4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RPRD1A
gene id: 9615:RPRD1A
uniprot id: A0A8C0S1C1
uniprot id: A0A8I3N9S0
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9615:RBM17
gene id: 9615:RBM17
uniprot id: A0A8C0LVF0
uniprot id: A0A8I3MLP9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9615:WDR4
gene id: 9615:WDR4
uniprot id: A0A8C0TVZ5
uniprot id: A0A8I3NY53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit METTL1.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

9615:LOC490346
gene id: 9615:LOC490346
uniprot id: A0A8C0PNF9
uniprot id: A0A8I3ME89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:TESMIN
gene id: 9615:TESMIN
uniprot id: A0A8P0SPV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9615:PNO1
gene id: 9615:PNO1
uniprot id: A0A8C0QC16
uniprot id: A0A8I3PK64
names: Similarity
messages: Belongs to the PNO1 family.

9615:LOC606845
gene id: 9615:LOC606845
uniprot id: A0A8C0NKV1
uniprot id: A0A8I3MPI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9615:DDR1
gene id: 9615:DDR1
uniprot id: A0A8I3NKP0
names: Subcellular Location Annotation
messages: Membrane

9615:TOMM20
gene id: 9615:TOMM20
uniprot id: A0A8C0MDI3
uniprot id: A0A8I3RSX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:MCRIP1
gene id: 9615:MCRIP1
uniprot id: A0A8C0PKN0
uniprot id: A0A8P0SBD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9615:ARRDC2
gene id: 9615:ARRDC2
uniprot id: A0A8C0RMP9
uniprot id: A0A8C0S3L9
uniprot id: A0A8I3PPQ6
uniprot id: A0A8I3S831
names: Similarity
messages: Belongs to the arrestin family.

9615:TCF4
gene id: 9615:TCF4
uniprot id: P15881
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2 (By similarity). Interacts with AGBL1 (By similarity).
messages: Nucleus
messages: Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). Binds to the thyroglobulin promoter.
messages: Widely expressed.

9615:EMG1
gene id: 9615:EMG1
uniprot id: A0A8C0NYH7
uniprot id: A0A8I3PLM1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9615:DYNLT3
gene id: 9615:DYNLT3
uniprot id: Q8SPS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).
messages: Belongs to the dynein light chain Tctex-type family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA (By similarity).
messages: Nucleus
messages: cytoskeleton
messages: kinetochore

9615:C5AR1
gene id: 9615:C5AR1
uniprot id: P30992
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Homodimer. May also form higher-order oligomers. Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR.
messages: Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to C5a.
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1472004). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).
messages: Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.

9615:SERPINA12
gene id: 9615:SERPINA12
uniprot id: A0A8I3RSM5
names: Similarity
messages: Belongs to the serpin family.

9615:CX3CR1
gene id: 9615:CX3CR1
uniprot id: H1ADZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9615:HOXB6
gene id: 9615:HOXB6
uniprot id: A0A8C0M3W2
uniprot id: A0A8I3N2L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:PLA2G3
gene id: 9615:PLA2G3
uniprot id: A0A8C0TLK4
uniprot id: A0A8I3PFI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9615:RAC1
gene id: 9615:RAC1
uniprot id: P62999
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Cytoplasm
messages: GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome.
messages: Interacts with NISCH. Interacts with PIP5K1A. Interacts with the GTP-bound form of RAB7A. Interacts with SRGAP2. Interacts with CYFIP1/SRA-1. Interacts with PLXNB3. Interacts with ARHGDIA; the interaction is induced by SEMA5A, mediated through PLXNB3 and inactivates and stabilizes RAC1. Interacts (GTP-bound form preferentially) with PKN2 (via the REM repeats); the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with the GEF proteins PREX1, RASGRF2, FARP1, FARP2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, BAIAP2L1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2. Interacts with NOXA1. Interacts with ARHGEF2. Interacts with TBC1D2. Interacts with UNKL. Interacts with USP6. Interacts with SPATA13. Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2. Interacts with ITGB4. Interacts with S100A8 and calprotectin (S100A8/9). Interacts with PACSIN2. Interacts with ITGB1BP1. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RAPH1 (via Ras associating and PH domains). Interacts with MTSS2 (via IMD domain); this interaction may be important to potentiate PDGF-induced RAC1 activation. Interacts with PAK2. Interacts (GTP-bound form) with SH3RF1 and SH3RF3. Found in a complex with SH3RF1, MAPK8IP1/JIP1, MAP3K11/MLK3, MAP2K7/MKK7 and MAPK8/JNK1. …
messages: Melanosome
messages: Nucleus
messages: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (By similarity). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3 (By similarity). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity).
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. GTP hydrolysis is stimulated by ARHGAP30.
messages: Synapse
messages: The effector region mediates interaction with DEF6.
messages: dendrite
messages: lamellipodium

9615:PPP2R2A
gene id: 9615:PPP2R2A
uniprot id: A0A8C0P811
uniprot id: A0A8I3RXP9
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9615:TIMP3
gene id: 9615:TIMP3
uniprot id: A0A8C0MG55
uniprot id: F5CBP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts with EFEMP1.
messages: extracellular matrix

9615:SLC13A2
gene id: 9615:SLC13A2
uniprot id: A0A8C0TCV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9615:STX4
gene id: 9615:STX4
uniprot id: A0A8I3NNE2
names: Similarity
messages: Belongs to the syntaxin family.

9615:OR5H12
gene id: 9615:OR5H12
uniprot id: A0A8I3S1Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CLCN6
gene id: 9615:CLCN6
uniprot id: A0A8C0NIH8
uniprot id: A0A8I3MK25
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SLC4A3
gene id: 9615:SLC4A3
uniprot id: A0A8C0RJF0
uniprot id: A0A8C0S8F2
uniprot id: A0A8I3Q4Q8
uniprot id: E3W283
uniprot id: E3W284
uniprot id: E3W285
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9615:CDIPT
gene id: 9615:CDIPT
uniprot id: A0A8C0LWU7
uniprot id: A0A8P0NTG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9615:ACTR1B
gene id: 9615:ACTR1B
uniprot id: A0A8C0RLZ0
uniprot id: A0A8I3S2X1
names: Similarity
messages: Belongs to the actin family.

9615:SAP18
gene id: 9615:SAP18
uniprot id: A0A8C0RSG0
names: Similarity
messages: Belongs to the SAP18 family.

9615:TMEM218
gene id: 9615:TMEM218
uniprot id: A0A8C0NDU3
uniprot id: A0A8I3RYG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9615:CYBA
gene id: 9615:CYBA
uniprot id: A7E3M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9615:FMO1
gene id: 9615:FMO1
uniprot id: Q95LA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (By similarity). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (By similarity). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity).
messages: Endoplasmic reticulum membrane
messages: Liver.

9615:CDC42SE2
gene id: 9615:CDC42SE2
uniprot id: A0A8C0YUL1
uniprot id: A0A8I3N9L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9615:BDKRB1
gene id: 9615:BDKRB1
uniprot id: Q9BDQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
messages: Cell membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9615:RRM2
gene id: 9615:RRM2
uniprot id: A0A8C0RDC7
uniprot id: A0A8P0PBR8
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9615:CLN3
gene id: 9615:CLN3
uniprot id: A0A8C0LS63
uniprot id: A0A8I3ML38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

9615:TSR2
gene id: 9615:TSR2
uniprot id: A0A8C0P9K5
uniprot id: A0A8I3QLL6
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9615:MS4A5
gene id: 9615:MS4A5
uniprot id: A0A8C0QB63
names: Similarity
messages: Belongs to the MS4A family.

9615:BGN
gene id: 9615:BGN
uniprot id: O02678
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity).
messages: May be involved in collagen fiber assembly.
messages: The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.
messages: extracellular matrix

9615:PCNA
gene id: 9615:PCNA
uniprot id: A0A8C0QFQ6
uniprot id: A0A8I3QKL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9615:ARHGDIB
gene id: 9615:ARHGDIB
uniprot id: A0A8C0TMJ5
uniprot id: A0A8I3P6H9
names: Similarity
messages: Belongs to the Rho GDI family.

9615:COG4
gene id: 9615:COG4
uniprot id: A0A8C0REW2
uniprot id: A0A8I3MVA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9615:PLPPR4
gene id: 9615:PLPPR4
uniprot id: A0A8C0RL73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9615:BAG6
gene id: 9615:BAG6
uniprot id: A0A8C0MI66
uniprot id: A0A8C0S6N0
uniprot id: A0A8C0S773
uniprot id: A0A8I3NHV1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: extracellular exosome

9615:DEGS2
gene id: 9615:DEGS2
uniprot id: A0A8I3MPI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:TMEM33
gene id: 9615:TMEM33
uniprot id: A0A8C0MYG0
uniprot id: A0A8I3NMP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9615:BPIFA1
gene id: 9615:BPIFA1
uniprot id: A0A8C0QES4
uniprot id: A0A8P0N9U9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
messages: Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.
messages: Secreted

9615:SLC25A45
gene id: 9615:SLC25A45
uniprot id: A0A8C0MUE4
uniprot id: A0A8C0N1L2
uniprot id: A0A8I3PS25
uniprot id: A0A8I3Q2S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:ZBED5
gene id: 9615:ZBED5
uniprot id: A4Z944
names: Miscellaneous
messages: May be derived from an ancient transposon that has lost its ability to translocate.

9615:MOGAT1
gene id: 9615:MOGAT1
uniprot id: A0A8C0SB49
uniprot id: A0A8P0SKF9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:LIPC
gene id: 9615:LIPC
uniprot id: A0A8P0SPQ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:PLIN1
gene id: 9615:PLIN1
uniprot id: A0A8I3RQT5
names: Similarity
messages: Belongs to the perilipin family.

9615:ATOX1
gene id: 9615:ATOX1
uniprot id: Q9TT99
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATX1 family.
messages: Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity).
messages: Interacts with ATP7B (By similarity). Interacts with ATP7A (By similarity).
messages: The heavy-metal-associated domain (HMA) coordinates a Cu(+) ion via the cysteine residues within the CXXC motif. The transfer of Cu(+) ion from ATOX1 to ATP7A involves the formation of a three-coordinate Cu(+)-bridged heterodimer where the metal is shared between the two metal binding sites of ATOX1 and ATP7A. The Cu(+) ion appears to switch between two coordination modes, forming two links with one protein and one with the other. Cisplatin, a chemotherapeutic drug, can bind the CXXC motif and hinder the release of Cu(+) ion.

9615:PDC
gene id: 9615:PDC
uniprot id: O77560
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosducin family.
messages: Defects in PDC are the cause of photoreceptor dysplasia (PD); an autosomal recessive disease of miniature schnauzer dogs causing retinal degeneration.
messages: Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.
messages: Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.
messages: Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.
messages: Nucleus
messages: Photoreceptor inner segment
messages: cytosol
messages: photoreceptor outer segment

9615:STMN4
gene id: 9615:STMN4
uniprot id: A0A8C0P9P3
uniprot id: A0A8C0RSC9
uniprot id: A0A8I3NHQ3
uniprot id: A0A8I3NM27
uniprot id: A0A8I3NPJ8
names: Similarity
messages: Belongs to the stathmin family.

9615:NRTN
gene id: 9615:NRTN
uniprot id: A0A8C0TVN1
uniprot id: E2R534
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9615:DLA88
gene id: 9615:DLA88
uniprot id: O46882
names: Similarity
messages: Belongs to the MHC class I family.

9615:PDGFRA
gene id: 9615:PDGFRA
uniprot id: A0A8C0STE2
uniprot id: A0A8I3NAN8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9615:TPPP3
gene id: 9615:TPPP3
uniprot id: A0A8C0SWX1
uniprot id: A0A8I3N563
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: cytoskeleton

9615:EBP
gene id: 9615:EBP
uniprot id: A0A8P0PEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:MCHR1
gene id: 9615:MCHR1
uniprot id: A0A8C0PB68
uniprot id: Q8MIP6
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

9615:AP1B1
gene id: 9615:AP1B1
uniprot id: A0A8C0T6Q2
uniprot id: A0A8I3Q4K4
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9615:MBTPS1
gene id: 9615:MBTPS1
uniprot id: A0A8P0SNX8
names: Similarity
messages: Belongs to the peptidase S8 family.

9615:DRGX
gene id: 9615:DRGX
uniprot id: A0A8C0NTF5
uniprot id: A0A8I3PDM0
names: Subcellular Location Annotation
messages: Nucleus

9615:IL36G
gene id: 9615:IL36G
uniprot id: A0A8I3N8L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9615:SLC4A5
gene id: 9615:SLC4A5
uniprot id: A0A8C0SMZ3
uniprot id: A0A8I3PBC9
uniprot id: A0A8I3PG85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9615:NCAPD2
gene id: 9615:NCAPD2
uniprot id: A0A8C0Z2G8
uniprot id: A0A8I3Q275
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

9615:FCHO1
gene id: 9615:FCHO1
uniprot id: A0A8C0NWM4
uniprot id: A0A8I3PR98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

9615:RETN
gene id: 9615:RETN
uniprot id: A0A8C0PKD7
uniprot id: A0A8I3Q3Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9615:FAM13B
gene id: 9615:FAM13B
uniprot id: A0A8C0MH97
uniprot id: A0A8C0MJA6
uniprot id: A0A8I3NTE9
uniprot id: A0A8I3P3E4
names: Similarity
messages: Belongs to the FAM13 family.

9615:CLIC5
gene id: 9615:CLIC5
uniprot id: A0A8C0REG2
uniprot id: A0A8I3NQ32
uniprot id: A0A8P0P9Q1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9615:TTC19
gene id: 9615:TTC19
uniprot id: A0A8C0M7E1
uniprot id: A0A8I3MR79
names: Similarity
messages: Belongs to the TTC19 family.

9615:TGFB1I1
gene id: 9615:TGFB1I1
uniprot id: A0A8C0S479
uniprot id: A0A8I3NG43
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.
messages: Nucleus matrix
messages: The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
messages: cytoskeleton
messages: focal adhesion

9615:E2F4
gene id: 9615:E2F4
uniprot id: A0A8I3N364
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9615:ISCA2
gene id: 9615:ISCA2
uniprot id: A0A8C0P2Z5
uniprot id: A0A8I3NJ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9615:PMS2
gene id: 9615:PMS2
uniprot id: A0A8C0P006
uniprot id: A0A8C0SHR0
uniprot id: A0A8I3NEX7
uniprot id: A0A8P0P7G7
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9615:ELOF1
gene id: 9615:ELOF1
uniprot id: A0A8C0NWN9
uniprot id: A0A8I3S0A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9615:ATP6V0A1
gene id: 9615:ATP6V0A1
uniprot id: A0A8C0LW48
uniprot id: A0A8C0S097
uniprot id: A0A8I3NLM3
uniprot id: A0A8I3RWI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9615:OST4
gene id: 9615:OST4
uniprot id: P0CU66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST4 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (By similarity). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (PubMed:29519914).
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes.

9615:CDC37L1
gene id: 9615:CDC37L1
uniprot id: A0A8C0PZN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9615:LIMS1
gene id: 9615:LIMS1
uniprot id: A0A8C0PAG7
uniprot id: A0A8C0PDK7
uniprot id: A0A8C0SNU6
uniprot id: A0A8C0SQL4
uniprot id: A0A8C0YZ34
uniprot id: A0A8I3MXQ5
uniprot id: A0A8I3N639
uniprot id: A0A8I3N8H0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9615:RALY
gene id: 9615:RALY
uniprot id: M9PM25
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9615:ATG9A
gene id: 9615:ATG9A
uniprot id: A0A8C0TQP7
uniprot id: A0A8I3QTY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9615:ADAM21
gene id: 9615:ADAM21
uniprot id: A0A8C0PKQ8
uniprot id: A0A8I3RTZ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:IGF2BP1
gene id: 9615:IGF2BP1
uniprot id: A0A8C0Q723
uniprot id: A0A8I3NB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9615:FUT1
gene id: 9615:FUT1
uniprot id: A0A8C0PMR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9615:CD8B
gene id: 9615:CD8B
uniprot id: A0A8C0SQ09
uniprot id: A0A8P0SCN4
names: Subcellular Location Annotation
messages: Membrane

9615:SBF2
gene id: 9615:SBF2
uniprot id: A0A8C0MFP1
uniprot id: A0A8C0RDL8
uniprot id: A0A8I3NTI5
uniprot id: A0A8I3S0Q6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9615:TRH
gene id: 9615:TRH
uniprot id: A0A8C0NVG0
uniprot id: A0A8I3Q081
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9615:GOT2
gene id: 9615:GOT2
uniprot id: A0A8C0LW07
uniprot id: A0A8P0SDE3
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9615:TCL1B
gene id: 9615:TCL1B
uniprot id: A0A8C0MUM1
uniprot id: A0A8P0PD74
names: Similarity
messages: Belongs to the TCL1 family.

9615:GSTZ1
gene id: 9615:GSTZ1
uniprot id: A0A8C0SXG5
uniprot id: A0A8C0Z0F0
uniprot id: A0A8I3MVI4
uniprot id: A0A8I3N003
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9615:POU4F3
gene id: 9615:POU4F3
uniprot id: A0A8C0RC23
uniprot id: A0A8I3PMT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9615:ATP1A3
gene id: 9615:ATP1A3
uniprot id: A0A8C0QH55
uniprot id: A0A8I3MHA2
uniprot id: A0A8I3MIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9615:FAM118B
gene id: 9615:FAM118B
uniprot id: A0A8C0YZS8
uniprot id: A0A8I3NEN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

9615:CRBN
gene id: 9615:CRBN
uniprot id: A0A8C0RYL7
uniprot id: A0A8I3NIQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9615:PSKH2
gene id: 9615:PSKH2
uniprot id: A0A8C0TI45
uniprot id: A0A8I3P4I8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:OR4C11D
gene id: 9615:OR4C11D
uniprot id: A0A8P0PJQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CHRM4
gene id: 9615:CHRM4
uniprot id: A0A8C0SJA8
uniprot id: A0A8P0NB92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9615:MRPS33
gene id: 9615:MRPS33
uniprot id: A0A8C0MR07
uniprot id: A0A8I3QDM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9615:DSC1
gene id: 9615:DSC1
uniprot id: A0A8C0LWT5
uniprot id: A0A8I3NU71
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9615:PROKR2
gene id: 9615:PROKR2
uniprot id: A0A8C0P145
uniprot id: A0A8I3PUU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9615:TBCE
gene id: 9615:TBCE
uniprot id: A0A8C0PSC5
uniprot id: A0A8I3MQ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

9615:ATP6V1G2
gene id: 9615:ATP6V1G2
uniprot id: Q5WR09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).

9615:PPP1CA
gene id: 9615:PPP1CA
uniprot id: A0A8C0PCF1
uniprot id: A0A8I3NRM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9615:MRPL42
gene id: 9615:MRPL42
uniprot id: A0A8C0NHB9
uniprot id: A0A8I3S264
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9615:FPGS
gene id: 9615:FPGS
uniprot id: A0A8C0N3I7
uniprot id: A0A8P0P7N2
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

9615:HTR2C
gene id: 9615:HTR2C
uniprot id: Q60F97
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis (By similarity).
messages: Interacts with MPDZ. Interacts with ARRB2 (By similarity).
messages: N-glycosylated.
messages: The PDZ domain-binding motif is involved in the interaction with MPDZ.

9615:CTSC
gene id: 9615:CTSC
uniprot id: O97578
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Binds 1 Cl(-) ion per heavy chain.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.
messages: The N-terminus of the heavy chain is heterogeneously processed to produce four different chains.
messages: Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase (By similarity).

9615:LOC478720
gene id: 9615:LOC478720
uniprot id: A0A8C0YZQ5
uniprot id: A0A8I3P6X4
names: Similarity
messages: Belongs to the TMEM14 family.

9615:ITM2C
gene id: 9615:ITM2C
uniprot id: A0A8I3PI18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9615:SLC25A21
gene id: 9615:SLC25A21
uniprot id: A0A8C0M4D3
uniprot id: A0A8I3MMD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:CLCN7
gene id: 9615:CLCN7
uniprot id: A0A8P0P8M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9615:TCAF1
gene id: 9615:TCAF1
uniprot id: A0A8C0MGB9
uniprot id: A0A8I3NMH4
names: Similarity
messages: Belongs to the TCAF family.

9615:RAB4B
gene id: 9615:RAB4B
uniprot id: P61017
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Serotonylation of Gln-67 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.
messages: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Protein transport. Probably involved in vesicular traffic (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).

9615:GPR39
gene id: 9615:GPR39
uniprot id: A0A8I3RTK7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:CACNA1S
gene id: 9615:CACNA1S
uniprot id: A0A8C0PGF9
uniprot id: A0A8C0RSY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9615:TAMM41
gene id: 9615:TAMM41
uniprot id: A0A8C0Z4N5
uniprot id: A0A8I3NCU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9615:SLC5A5
gene id: 9615:SLC5A5
uniprot id: A0A8C0P3J1
uniprot id: A0A8C0S487
uniprot id: A0A8I3PS88
uniprot id: A0A8I3PWH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9615:HLF
gene id: 9615:HLF
uniprot id: A0A8C0N6X2
uniprot id: A0A8I3NX86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9615:RIBC1
gene id: 9615:RIBC1
uniprot id: A0A8C0T535
uniprot id: A0A8I3Q109
uniprot id: A0A8P0NHQ9
names: Similarity
messages: Belongs to the RIB43A family.

9615:TINAG
gene id: 9615:TINAG
uniprot id: A0A8C0NDM9
names: Similarity
messages: Belongs to the peptidase C1 family.

9615:AUH
gene id: 9615:AUH
uniprot id: A0A8C0M2E9
uniprot id: A0A8C0M2H0
uniprot id: A0A8I3P3A4
uniprot id: A0A8I3PC86
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9615:EXOC7
gene id: 9615:EXOC7
uniprot id: A0A8C0LZG6
uniprot id: A0A8C0R9Z2
uniprot id: A0A8C0RA01
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9615:C1R
gene id: 9615:C1R
uniprot id: A0A8C0RPP3
uniprot id: A0A8I3PTX7
names: Caution
names: Function
names: Subunit
messages: C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.
messages: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RARRES2
gene id: 9615:RARRES2
uniprot id: A0A8C0PHW2
uniprot id: A0A8P0SA67
names: Subcellular Location Annotation
messages: Secreted

9615:LOC481834
gene id: 9615:LOC481834
uniprot id: A0A8I3N459
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:IFNAR1
gene id: 9615:IFNAR1
uniprot id: A0A8C0MNF2
uniprot id: F1PRZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9615:FAM151A
gene id: 9615:FAM151A
uniprot id: A0A8C0M546
uniprot id: D0VE84
names: Similarity
messages: Belongs to the FAM151 family.

9615:SETDB2
gene id: 9615:SETDB2
uniprot id: A0A8C0NLX2
uniprot id: A0A8C0NRM4
uniprot id: A0A8C0YTC3
uniprot id: A0A8P0N760
uniprot id: A0A8P0TAJ6
names: Subcellular Location Annotation
messages: Chromosome

9615:IZUMO2
gene id: 9615:IZUMO2
uniprot id: A0A8C0LWQ8
uniprot id: A0A8I3P6N2
names: Similarity
messages: Belongs to the Izumo family.

9615:NCBP1
gene id: 9615:NCBP1
uniprot id: A0A8C0M763
uniprot id: A0A8I3NNY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9615:DNASE1
gene id: 9615:DNASE1
uniprot id: Q767J3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DNase I family.
messages: Divalent metal cations. Prefers Ca(2+) or Mg(2+).
messages: Highest expression in pancreas.
messages: Nucleus envelope
messages: Secreted
messages: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:14688237). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:14688237). Binds specifically to G-actin and blocks actin polymerization (PubMed:14688237). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
messages: Zymogen granule

9615:BLOC1S1
gene id: 9615:BLOC1S1
uniprot id: A0A8I3RU46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space

9615:CBWD1
gene id: 9615:CBWD1
uniprot id: A0A8C0RK28
uniprot id: A0A8I3MKV1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9615:PTGFR
gene id: 9615:PTGFR
uniprot id: A0A8C0SU69
uniprot id: Q45FN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:CHGB
gene id: 9615:CHGB
uniprot id: A0A8C0P546
uniprot id: A0A8I3Q1Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9615:SLITRK4
gene id: 9615:SLITRK4
uniprot id: A0A8C0MH23
uniprot id: A0A8I3P9D4
names: Similarity
messages: Belongs to the SLITRK family.

9615:SLC39A14
gene id: 9615:SLC39A14
uniprot id: A0A8C0THU8
uniprot id: A0A8I3PPF0
names: Subcellular Location Annotation
messages: Membrane

9615:SAMM50
gene id: 9615:SAMM50
uniprot id: A0A8C0SCB6
uniprot id: A0A8I3NCA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9615:SHMT2
gene id: 9615:SHMT2
uniprot id: A0A8C0MTK9
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9615:DARS2
gene id: 9615:DARS2
uniprot id: A0A8C0LWD8
uniprot id: A0A8C0M1N0
uniprot id: A0A8P0SJ98
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9615:USP44
gene id: 9615:USP44
uniprot id: A0A8C0Q8Z5
uniprot id: A0A8I3PX43
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9615:SLC2A4
gene id: 9615:SLC2A4
uniprot id: A0A8C0Q762
uniprot id: A0A8I3PA13
uniprot id: Q9XST2
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Binds to DAXX. Interacts via its N-terminus with SRFBP1 (By similarity). Interacts with NDUFA9 (By similarity). Interacts with TRARG1; the interaction is required for proper SLC2A4 recycling after insulin stimulation (By similarity).
messages: Cell membrane
messages: Endomembrane system
messages: Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
messages: Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.
messages: Membrane
messages: Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane.
messages: Sumoylated.
messages: The dileucine internalization motif is critical for intracellular sequestration.
messages: perinuclear region

9615:SLC7A5
gene id: 9615:SLC7A5
uniprot id: K0J2W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9615:MRPL20
gene id: 9615:MRPL20
uniprot id: A0A8C0RXC9
uniprot id: A0A8I3Q621
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9615:SMIM15
gene id: 9615:SMIM15
uniprot id: A0A8I3RVL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9615:ADAMTS14
gene id: 9615:ADAMTS14
uniprot id: A0A8C0NA17
uniprot id: A0A8P0NFQ9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:SLC1A6
gene id: 9615:SLC1A6
uniprot id: Q9N1R2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A6 subfamily.
messages: Cell membrane
messages: Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.
messages: Detected in brain, cerebellum and hippocampus.
messages: Homotrimer.
messages: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate.

9615:ADAMTS6
gene id: 9615:ADAMTS6
uniprot id: A0A8C0RWD3
uniprot id: A0A8I3N140
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:NKX2-5
gene id: 9615:NKX2-5
uniprot id: A0A8C0LX42
uniprot id: Q5J2F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

9615:LOC490690
gene id: 9615:LOC490690
uniprot id: A0A8C0MBW0
uniprot id: A0A8I3MMN3
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9615:BECN1
gene id: 9615:BECN1
uniprot id: A0A8C0RAA1
uniprot id: A0A8C0TAY3
uniprot id: A0A8I3MVR6
uniprot id: A0A8I3N683
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9615:GGH
gene id: 9615:GGH
uniprot id: A0A8I3SCF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9615:NDUFAF3
gene id: 9615:NDUFAF3
uniprot id: A0A8C0TGF5
uniprot id: A0A8I3Q2V0
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9615:AVPR2
gene id: 9615:AVPR2
uniprot id: C5HF07
uniprot id: O77808
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Interacts with ARRDC4 (By similarity). Identified in a complex containing at least ARRDC4, V2R and HGS (By similarity). Interacts with TMEM147 (By similarity).
messages: Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity).

9615:MRGPRF
gene id: 9615:MRGPRF
uniprot id: A0A8C0QBX9
uniprot id: A0A8I3MT39
uniprot id: W8W3H1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:SLC2A13
gene id: 9615:SLC2A13
uniprot id: A0A8I3S7S0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9615:DHODH
gene id: 9615:DHODH
uniprot id: A0A8C0N1H5
uniprot id: A0A8P0NUN4
uniprot id: A0A8P0P8S9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9615:FRAS1
gene id: 9615:FRAS1
uniprot id: A0A8P0SV35
names: Similarity
messages: Belongs to the FRAS1 family.

9615:TPT1
gene id: 9615:TPT1
uniprot id: A0A8C0SSK0
uniprot id: A0A8I3N0W8
names: Similarity
messages: Belongs to the TCTP family.

9615:ACTR8
gene id: 9615:ACTR8
uniprot id: A0A8C0PKZ3
uniprot id: A0A8I3Q240
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9615:TOP1
gene id: 9615:TOP1
uniprot id: A0A8C0T9U8
uniprot id: A0A8P0SE48
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9615:EFNA4
gene id: 9615:EFNA4
uniprot id: A0A8C0PRQ5
uniprot id: A0A8I3NQ24
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:CAFA-T2R67
gene id: 9615:CAFA-T2R67
uniprot id: Q2ABC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:LOC477647
gene id: 9615:LOC477647
uniprot id: A0A8I3NXS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:NIPAL3
gene id: 9615:NIPAL3
uniprot id: A0A8C0LXT0
uniprot id: A0A8I3NHQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9615:DESI1
gene id: 9615:DESI1
uniprot id: A0A8C0SXS2
names: Similarity
messages: Belongs to the DeSI family.

9615:PIGH
gene id: 9615:PIGH
uniprot id: A0A8C0NJ35
uniprot id: A0A8I3MSQ9
names: Similarity
messages: Belongs to the PIGH family.

9615:FAM199X
gene id: 9615:FAM199X
uniprot id: A0A8I3NYW9
names: Similarity
messages: Belongs to the FAM199 family.

9615:BCAP31
gene id: 9615:BCAP31
uniprot id: A0A8C0T297
uniprot id: A0A8I3Q0S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9615:BMP5
gene id: 9615:BMP5
uniprot id: A0A8C0NEM6
uniprot id: A0A8I3RYW2
names: Similarity
messages: Belongs to the TGF-beta family.

9615:NEDD8
gene id: 9615:NEDD8
uniprot id: A0A8C0PZK1
uniprot id: A0A8I3N2C0
names: Similarity
messages: Belongs to the ubiquitin family.

9615:TSPAN2
gene id: 9615:TSPAN2
uniprot id: A0A8C0S9N8
uniprot id: A0A8P0SEM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9615:CYP2A7
gene id: 9615:CYP2A7
uniprot id: Q307K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:DRD2
gene id: 9615:DRD2
uniprot id: Q9GJU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:11054572). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
messages: Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with CADPS and CADPS2 (By similarity). Interacts with GPRASP1, PPP1R9B and CLIC6. Interacts with ARRB2 (By similarity). Interacts with HTR2A (By similarity). Interacts with DRD1. Interacts with KCNA2 (By similarity).
messages: Golgi apparatus membrane
messages: Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8.

9615:RHBDD1
gene id: 9615:RHBDD1
uniprot id: A0A8C0T6U2
uniprot id: A0A8I3NWS2
names: Subcellular Location Annotation
messages: Membrane

9615:SLC34A1
gene id: 9615:SLC34A1
uniprot id: A0A8C0M6W3
uniprot id: A0A8I3NFY6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9615:TADA2A
gene id: 9615:TADA2A
uniprot id: A0A8C0P9X3
uniprot id: A0A8C0PYR1
uniprot id: A0A8I3N6B2
names: Subcellular Location Annotation
messages: Nucleus

9615:CCR2
gene id: 9615:CCR2
uniprot id: A0A8C0SZR1
uniprot id: A0A8I3NHP0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:TCHP
gene id: 9615:TCHP
uniprot id: A0A8P0TPK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCHP family.
messages: cytoskeleton

9615:GABRG3
gene id: 9615:GABRG3
uniprot id: A0A8C0Q305
uniprot id: A0A8I3P8N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:GSG1L
gene id: 9615:GSG1L
uniprot id: A0A8C0PZU2
uniprot id: A0A8I3MJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9615:RBL1
gene id: 9615:RBL1
uniprot id: A0A8C0SJ08
uniprot id: A0A8I3Q0G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9615:PREPL
gene id: 9615:PREPL
uniprot id: A0A8C0N5W7
uniprot id: A0A8C0S0E8
uniprot id: A0A8I3PQA0
uniprot id: A0A8I3PTZ6
names: Similarity
messages: Belongs to the peptidase S9A family.

9615:PSMC6
gene id: 9615:PSMC6
uniprot id: A0A8C0M7Z2
uniprot id: A0A8I3RRR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9615:CD48
gene id: 9615:CD48
uniprot id: A0A8C0SQV8
uniprot id: A0A8I3S7I8
names: Subcellular Location Annotation
messages: Membrane

9615:ALDH3B1
gene id: 9615:ALDH3B1
uniprot id: A0A8C0S2P9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:TMEM120B
gene id: 9615:TMEM120B
uniprot id: A0A8C0SWS8
uniprot id: A0A8I3PPD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9615:RPGRIP1
gene id: 9615:RPGRIP1
uniprot id: F1PKQ6
names: Similarity
messages: Belongs to the RPGRIP1 family.

9615:UBQLN2
gene id: 9615:UBQLN2
uniprot id: A0A8C0N9G5
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9615:VAC14
gene id: 9615:VAC14
uniprot id: A0A8C0SVY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9615:PCMT1
gene id: 9615:PCMT1
uniprot id: A0A8C0N6C2
uniprot id: A0A8I3P8Y8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9615:ARL5B
gene id: 9615:ARL5B
uniprot id: A0A8C0PTF3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9615:SPTLC3
gene id: 9615:SPTLC3
uniprot id: A0A8I3PMG7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9615:YIPF6
gene id: 9615:YIPF6
uniprot id: A0A8C0TDZ9
uniprot id: A0A8I3PZS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9615:APLP2
gene id: 9615:APLP2
uniprot id: A0A8C0M5I6
uniprot id: A0A8C0SDW3
uniprot id: A0A8C0YWW2
uniprot id: A0A8I3MVF1
uniprot id: A0A8I3N111
uniprot id: A0A8I3N3Q6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ONECUT1
gene id: 9615:ONECUT1
uniprot id: A0A8C0NJ34
uniprot id: A0A8I3PVL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9615:DIS3L2
gene id: 9615:DIS3L2
uniprot id: A0A8I3PTC4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

9615:CCN3
gene id: 9615:CCN3
uniprot id: A0A8C0RCV6
uniprot id: A0A8I3N0U3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:TMEM17
gene id: 9615:TMEM17
uniprot id: A0A8P0S8U9
names: Subcellular Location Annotation
messages: Membrane

9615:PGLS
gene id: 9615:PGLS
uniprot id: A0A8C0P174
uniprot id: A0A8I3SAK1
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

9615:TRMT10C
gene id: 9615:TRMT10C
uniprot id: A0A8I3PBL7
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9615:LOC480667
gene id: 9615:LOC480667
uniprot id: A0A8C0YX74
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9615:LHPP
gene id: 9615:LHPP
uniprot id: A0A8C0TB60
uniprot id: A0A8I3PQG8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9615:GOT1
gene id: 9615:GOT1
uniprot id: A0A8C0TYI7
uniprot id: A0A8I3QCW7
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9615:QRFPR
gene id: 9615:QRFPR
uniprot id: A0A8P0N6Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9615:WDR83OS
gene id: 9615:WDR83OS
uniprot id: A0A8C0TSD6
uniprot id: A0A8I3NQW8
names: Similarity
messages: Belongs to the Asterix family.

9615:VAMP4
gene id: 9615:VAMP4
uniprot id: A0A8C0LYJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9615:LOC482174
gene id: 9615:LOC482174
uniprot id: A0A8C0PKT0
uniprot id: A0A8I3N4R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9615:TREX1
gene id: 9615:TREX1
uniprot id: A0A8C0PDI4
uniprot id: A0A8C0PDL7
uniprot id: A0A8I3MZA0
uniprot id: A0A8I3N0M9
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9615:TUBB6
gene id: 9615:TUBB6
uniprot id: A0A8C0M5E1
uniprot id: A0A8I3MYG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:ZDHHC7
gene id: 9615:ZDHHC7
uniprot id: A0A8C0SNA9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:ADCY6
gene id: 9615:ADCY6
uniprot id: A0A8C0P6Z2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9615:VAMP5
gene id: 9615:VAMP5
uniprot id: A0A8P0SCW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9615:NIPA1
gene id: 9615:NIPA1
uniprot id: A0A8C0RF28
uniprot id: A0A8I3NUF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9615:OR52B4
gene id: 9615:OR52B4
uniprot id: G3FJF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:UCN2
gene id: 9615:UCN2
uniprot id: A0A8C0NVK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9615:HOXC12
gene id: 9615:HOXC12
uniprot id: A0A8C0Z324
uniprot id: A0A8I3P617
names: Subcellular Location Annotation
messages: Nucleus

9615:CYP4B1
gene id: 9615:CYP4B1
uniprot id: A0A8C0YZ16
uniprot id: A0A8I3NUL1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:OR5H13
gene id: 9615:OR5H13
uniprot id: A0A8C0TDU0
uniprot id: A0A8I3NXK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:RPL36AL
gene id: 9615:RPL36AL
uniprot id: D0VWQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9615:CCDC124
gene id: 9615:CCDC124
uniprot id: A0A8C0S442
uniprot id: A0A8I3PLP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

9615:ANP32E
gene id: 9615:ANP32E
uniprot id: A0A8C0S468
uniprot id: A0A8I3NQK5
names: Similarity
messages: Belongs to the ANP32 family.

9615:OR7A74
gene id: 9615:OR7A74
uniprot id: Q95157
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Putative odorant or sperm cell receptor.

9615:HVCN1
gene id: 9615:HVCN1
uniprot id: A0A8C0TBC7
uniprot id: A0A8I3PXD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9615:TFPI2
gene id: 9615:TFPI2
uniprot id: A0A8C0S961
uniprot id: A0A8I3NZH5
names: Subcellular Location Annotation
messages: Secreted

9615:POU4F2
gene id: 9615:POU4F2
uniprot id: A0A8C0QMF3
uniprot id: A0A8I3NYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9615:TOR1B
gene id: 9615:TOR1B
uniprot id: A0A8C0MGZ3
uniprot id: A0A8I3PE10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9615:LOC100856702
gene id: 9615:LOC100856702
uniprot id: A0A8P0N6I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9615:MRPL23
gene id: 9615:MRPL23
uniprot id: A0A8I3NG61
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9615:SLC25A51
gene id: 9615:SLC25A51
uniprot id: A0A8C0M9K1
uniprot id: A0A8P0PRV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:F13B
gene id: 9615:F13B
uniprot id: A0A8C0PED8
uniprot id: A0A8I3MGM0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:NDUFA11
gene id: 9615:NDUFA11
uniprot id: A0A8C0PBD9
uniprot id: A0A8I3NKQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:AOX2
gene id: 9615:AOX2
uniprot id: Q2QB47
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9615:TRARG1
gene id: 9615:TRARG1
uniprot id: A0A8C0RVG4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9615:NR1H4
gene id: 9615:NR1H4
uniprot id: A0A8C0S616
uniprot id: A0A8C0S6D2
uniprot id: A0A8I3N2S7
uniprot id: A0A8P0STP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:STEAP3
gene id: 9615:STEAP3
uniprot id: A0A8I3Q5X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9615:SEPTIN4
gene id: 9615:SEPTIN4
uniprot id: A0A5F4C7B5
uniprot id: A0A8C0MRS7
uniprot id: A0A8C0PPY1
uniprot id: A0A8C0PUI1
uniprot id: A0A8C0RUQ8
uniprot id: A0A8I3S4Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9615:SLC15A5
gene id: 9615:SLC15A5
uniprot id: A0A8P0SH83
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9615:SUPT4H1
gene id: 9615:SUPT4H1
uniprot id: A0A8C0PR08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9615:GNG2
gene id: 9615:GNG2
uniprot id: A0A8P0PFL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:TXLNA
gene id: 9615:TXLNA
uniprot id: A0A8C0TC02
uniprot id: A0A8I3MU79
names: Similarity
messages: Belongs to the taxilin family.

9615:UBE2G2
gene id: 9615:UBE2G2
uniprot id: A0A8C0PEM6
uniprot id: A0A8C0PR53
uniprot id: A0A8I3S4V5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:FICD
gene id: 9615:FICD
uniprot id: A0A8I3Q076
names: Similarity
messages: Belongs to the fic family.

9615:TAS1R1
gene id: 9615:TAS1R1
uniprot id: A0A8C0MNP5
uniprot id: A0A8I3Q7L4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:DR1
gene id: 9615:DR1
uniprot id: A0A8C0N5Q9
uniprot id: A0A8I3NU10
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9615:COPS4
gene id: 9615:COPS4
uniprot id: A0A8C0NGW4
uniprot id: A0A8C0Z5P5
uniprot id: A0A8I3P5Y3
uniprot id: A0A8I3PE70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9615:PDE1A
gene id: 9615:PDE1A
uniprot id: Q95NB8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:TFAP2D
gene id: 9615:TFAP2D
uniprot id: A0A8C0M8Q3
uniprot id: A0A8I3MUF4
names: Similarity
messages: Belongs to the AP-2 family.

9615:COG3
gene id: 9615:COG3
uniprot id: A0A8C0YZF2
uniprot id: A0A8P0NRK2
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9615:LIAS
gene id: 9615:LIAS
uniprot id: A0A8P0SK96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9615:CCDC47
gene id: 9615:CCDC47
uniprot id: A0A8C0RJF2
uniprot id: A0A8I3P7X4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Rough endoplasmic reticulum membrane

9615:KRT33B
gene id: 9615:KRT33B
uniprot id: A0A8C0NSP5
uniprot id: A0A8I3NNI9
names: Similarity
messages: Belongs to the intermediate filament family.

9615:OR52U1C
gene id: 9615:OR52U1C
uniprot id: A0A8I3PES2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:MRPL3
gene id: 9615:MRPL3
uniprot id: A0A8C0TBA8
uniprot id: A0A8I3Q1K3
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9615:ARL2
gene id: 9615:ARL2
uniprot id: A0A8C0Z3L5
uniprot id: A0A8I3SAX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9615:CCL19
gene id: 9615:CCL19
uniprot id: A0A8C0S3R1
uniprot id: Q68AY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:EPHX1
gene id: 9615:EPHX1
uniprot id: A0A8C0M9X2
uniprot id: A0A8I3N7V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:FAAH
gene id: 9615:FAAH
uniprot id: A0A8C0RNU5
uniprot id: A0A8P0N732
names: Similarity
messages: Belongs to the amidase family.

9615:DGKG
gene id: 9615:DGKG
uniprot id: A0A8C0SQP6
uniprot id: A0A8I3NZ70
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9615:SLCO1B3
gene id: 9615:SLCO1B3
uniprot id: A0A8I3NUI6
uniprot id: C9EGT7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:EXTL1
gene id: 9615:EXTL1
uniprot id: A0A8P0NEL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:PRPF38A
gene id: 9615:PRPF38A
uniprot id: A0A8C0N1M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9615:EHD2
gene id: 9615:EHD2
uniprot id: A0A8C0PSB6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9615:MYH8
gene id: 9615:MYH8
uniprot id: Q076A4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9615:NIBAN1
gene id: 9615:NIBAN1
uniprot id: A0A8P0NF80
uniprot id: A0A8P0STA6
uniprot id: A0A8P0T9Z6
names: Similarity
messages: Belongs to the Niban family.

9615:CA11
gene id: 9615:CA11
uniprot id: A0A8C0NCY7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9615:PAQR9
gene id: 9615:PAQR9
uniprot id: A0A8C0MDJ5
uniprot id: A0A8I3Q0L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9615:SLC5A1
gene id: 9615:SLC5A1
uniprot id: A0A8C0TR03
uniprot id: Q5U9D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9615:DPH2
gene id: 9615:DPH2
uniprot id: A0A8C0N7X7
uniprot id: A0A8C0QCB3
uniprot id: A0A8I3QFS2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9615:SV2B
gene id: 9615:SV2B
uniprot id: A0A8C0TU33
uniprot id: A0A8I3MGK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9615:CBLIF
gene id: 9615:CBLIF
uniprot id: Q5XWD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Interacts with CUBN (via CUB domains).
messages: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity).
messages: Secreted

9615:LIM2
gene id: 9615:LIM2
uniprot id: A0A8C0Q1H6
uniprot id: A0A8I3MYZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

9615:FNTA
gene id: 9615:FNTA
uniprot id: A0A8C0RQI5
uniprot id: A0A8I3P9P2
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9615:PRKCG
gene id: 9615:PRKCG
uniprot id: A0A8C0RV32
uniprot id: E2R2X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane

9615:CPNE9
gene id: 9615:CPNE9
uniprot id: A0A8C0MPE5
names: Similarity
messages: Belongs to the copine family.

9615:ATG13
gene id: 9615:ATG13
uniprot id: A0A8C0PF86
uniprot id: A0A8C0SGP6
uniprot id: A0A8C0YX87
uniprot id: A0A8I3PTC5
uniprot id: A0A8I3PXN2
uniprot id: A0A8I3QDN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9615:RDH10
gene id: 9615:RDH10
uniprot id: A0A8C0Z005
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9615:LOC611901
gene id: 9615:LOC611901
uniprot id: A0A8I3N7A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9615:FLVCR2
gene id: 9615:FLVCR2
uniprot id: A0A8C0NVB0
uniprot id: A0A8I3P1S2
names: Subcellular Location Annotation
messages: Membrane

9615:OR4K15
gene id: 9615:OR4K15
uniprot id: A0A8C0TI08
uniprot id: A0A8I3NYI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:TFEC
gene id: 9615:TFEC
uniprot id: A0A8C0YZM2
uniprot id: A0A8I3MZG5
uniprot id: A0A8I3N2H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9615:INTS11
gene id: 9615:INTS11
uniprot id: A0A8C0LSE6
uniprot id: A0A8C0Q370
uniprot id: A0A8P0SNA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Nucleus

9615:LOC474938
gene id: 9615:LOC474938
uniprot id: A0A059V712
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9615:PPM1E
gene id: 9615:PPM1E
uniprot id: A0A8C0MHX9
uniprot id: A0A8I3S6N6
names: Similarity
messages: Belongs to the PP2C family.

9615:ST6GALNAC4
gene id: 9615:ST6GALNAC4
uniprot id: A0A8C0N9Q3
uniprot id: A0A8I3MSL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:PPARD
gene id: 9615:PPARD
uniprot id: Q0ZAQ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Lys-48'-linked polyubiquitinated; leading to proteasomal degradation. Deubiquitinated and stabilized by OTUD3.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Heterodimer with the retinoid X receptor (By similarity). Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity).
messages: Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
messages: Nucleus

9615:EMC7
gene id: 9615:EMC7
uniprot id: A0A8C0T3M1
uniprot id: A0A8I3PH25
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

9615:SKA3
gene id: 9615:SKA3
uniprot id: A0A8C0PAE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9615:SEC22B
gene id: 9615:SEC22B
uniprot id: A0A8P0NWL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9615:DDX1
gene id: 9615:DDX1
uniprot id: A0A8C0NB32
uniprot id: A0A8I3NV96
uniprot id: A0A8I3S1S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule

9615:LIX1
gene id: 9615:LIX1
uniprot id: A0A8C0NJQ4
uniprot id: A0A8I3MF81
names: Similarity
messages: Belongs to the LIX1 family.

9615:LIG4
gene id: 9615:LIG4
uniprot id: A0A8C0M8R8
uniprot id: A0A8I3PV38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9615:ACER1
gene id: 9615:ACER1
uniprot id: A0A8C0TTX6
uniprot id: A0A8I3RYI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9615:C10H2orf49
gene id: 9615:C10H2orf49
uniprot id: A0A8C0P9S8
uniprot id: A0A8C0QEH7
uniprot id: A0A8I3N255
uniprot id: A0A8I3NEV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9615:DCTN1
gene id: 9615:DCTN1
uniprot id: A0A8C0SKK4
uniprot id: A0A8I3P071
uniprot id: A0A8I3P8L8
uniprot id: A0A8I3S1I6
uniprot id: A0A8P0PI80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

9615:XPO4
gene id: 9615:XPO4
uniprot id: A0A8I3P888
uniprot id: A0A8I3PGU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

9615:REC8
gene id: 9615:REC8
uniprot id: A0A8P0PPD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9615:HS2ST1
gene id: 9615:HS2ST1
uniprot id: A0A8C0QL60
uniprot id: A0A8I3S128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9615:SMPD1
gene id: 9615:SMPD1
uniprot id: A0A8C0MWB3
uniprot id: A0A8I3RTW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

9615:RAN
gene id: 9615:RAN
uniprot id: P62825
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding. Acetylation at Lys-37 enhances the association with nuclear export components. Deacetylation of Lys-37 by SIRT7 regulates the nuclear export of NF-kappa-B subunit RELA/p65.
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Cytoplasm
messages: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation.
messages: Melanosome
messages: Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.
messages: Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis. Interacts with KPNB1 (PubMed:15864302). Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity. Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP. Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP. Interacts (GTP-bound form) with TNPO1; the interaction is direct. Interacts (GTP-bound form) with TNPO3; the interaction is direct (By similarity). Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity. Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity. Interacts with RANGRF, which promotes the release of bound guanine nucleotide. RANGRF and RCC1 compete for an overlapping binding site on RAN. Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex (PubMed:15602554). Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1. Identified in a complex composed of RAN, RANGAP1 and RANBP1. Identified in a complex that contains TNPO1, RAN and RANBP1. Identified in a nuclear export complex with XPO1. Found in a nuclear export complex with RANBP3 and XPO1. Interacts with RANBP2/NUP358. Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1 (By similarity). Found in a nuclear export complex with RAN, XPO5 and pre-miRNA (PubMed:19965479). Interacts (GTP-bound form) with XPO5 (PubMed:19965479). Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with RANBP9 and RANBP10. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TE…
messages: Nucleus
messages: Nucleus envelope
messages: cytosol

9615:MCM9
gene id: 9615:MCM9
uniprot id: A0A8P0N445
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9615:NKD1
gene id: 9615:NKD1
uniprot id: A0A8C0SHQ4
uniprot id: A0A8I3RRS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9615:HDX
gene id: 9615:HDX
uniprot id: A0A8C0YT96
names: Subcellular Location Annotation
messages: Nucleus

9615:R3HDML
gene id: 9615:R3HDML
uniprot id: A0A8C0TKW6
uniprot id: A0A8I3NTH7
names: Similarity
messages: Belongs to the CRISP family.

9615:RARA
gene id: 9615:RARA
uniprot id: Q5FBR4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated; acetylation is increased upon pulsatile shear stress and decreased upon oscillatory shear stress.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Heterodimer; with RXRA (By similarity). Binds DNA preferentially as a heterodimer (By similarity). RXRA serves as enhancer to induce RARA binding to RARE (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (By similarity). Interacts with NCOA7 in a ligand-inducible manner (By similarity). Interacts (via the ligand-binding domain) with PRAME; interaction is direct and ligand (retinoic acid)-dependent (By similarity). Interacts with PRKAR1A; the interaction negatively regulates RARA transcriptional activity (By similarity). Interacts with NCOR1 and NCOR2; the interaction occurs in the absence of ligand and represses transcriptional activity (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (By similarity). Interacts with CDK7; the interaction is enhanced by interaction with GTF2H3 (By similarity). Interacts with GTF2H3; the interaction requires prior phosphorylation on Ser-369 which then enhances interaction with CDK7. Interacts with PRMT2 (By similarity). Interacts with LRIF1 (By similarity). Interacts with ASXL1 and NCOA1 (By similarity). Interacts with ACTN4 (By similarity). In a complex with HDAC3, HDAC5 and HDAC7; the HDACs serve as corepressors of RARA, causing its deacetylation and inhibition of RARE DNA element binding; association with HDAC3, HDAC5 and HDAC7 is increased upon oscillatory shear stress (By similarity). In the absence of hormonal ligand, interacts with TACC1 (By similarity).
messages: Nucleus
messages: Phosphorylated on serine and threonine residues. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for the N-terminal AF1 transcriptional activity. Under stress conditions, MAPK8 enhances phosphorylation on Thr-181, Ser-445 and Ser-461 leading to RARA ubiquitination and degradation. Phosphorylation by AKT1 inhibits the transactivation activity. On retinoic acid stimulation, phosphorylation on Ser-369 by RPS6KA5 promotes interaction with GTF2H3 and the CDK7-mediated phosphorylation of Ser-77 (By similarity).
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Formation of heterocomplex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (By similarity). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (By similarity). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (By similarity).
messages: Sumoylated with SUMO2, mainly on Lys-399 which is also required for SENP6 binding. On all-trans retinoic acid (ATRA) binding, a confromational change may occur that allows sumoylation on two additional site, Lys-166 and Lys-171. Probably desumoylated by SENP6. Sumoylation levels determine nuclear localization and regulate ATRA-mediated transcriptional activity (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9615:BCAN
gene id: 9615:BCAN
uniprot id: H6VX53
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:DHRS11
gene id: 9615:DHRS11
uniprot id: A0A8C0PLJ9
uniprot id: A0A8I3Q1V9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:TES
gene id: 9615:TES
uniprot id: A0M8U6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

9615:ANKRD13A
gene id: 9615:ANKRD13A
uniprot id: A0A8C0P5K6
uniprot id: A0A8P0NCV8
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9615:SLC22A10
gene id: 9615:SLC22A10
uniprot id: A0A8C0MPT8
uniprot id: A0A8P0NGR9
names: Subcellular Location Annotation
messages: Membrane

9615:NDUFS3
gene id: 9615:NDUFS3
uniprot id: A0A8P0NAU8
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

9615:FAM214B
gene id: 9615:FAM214B
uniprot id: A0A8C0NJE7
uniprot id: A0A8I3N093
names: Similarity
messages: Belongs to the FAM214 family.

9615:PSMD13
gene id: 9615:PSMD13
uniprot id: A0A8C0TIV2
uniprot id: A0A8I3S6Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9615:OXSM
gene id: 9615:OXSM
uniprot id: A0A8I3PPX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9615:RAB3IP
gene id: 9615:RAB3IP
uniprot id: A0A8C0QF51
uniprot id: A0A8C0QR02
uniprot id: A0A8I3S0B6
names: Similarity
messages: Belongs to the SEC2 family.

9615:JRK
gene id: 9615:JRK
uniprot id: A0A8C0MWT8
uniprot id: A0A8I3NGS2
names: Subcellular Location Annotation
messages: Nucleus

9615:KCNH6
gene id: 9615:KCNH6
uniprot id: A0A8P0NEU0
names: Subcellular Location Annotation
messages: Membrane

9615:LLPH
gene id: 9615:LLPH
uniprot id: A0A8C0N155
uniprot id: A0A8I3NNR1
names: Similarity
messages: Belongs to the learning-associated protein family.

9615:KCNA5
gene id: 9615:KCNA5
uniprot id: A0A8C0PF84
uniprot id: Q866G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

9615:DHTKD1
gene id: 9615:DHTKD1
uniprot id: A0A8C0Q1B6
uniprot id: A0A8I3RQS7
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9615:RPL13
gene id: 9615:RPL13
uniprot id: A0A8C0N2F6
uniprot id: A0A8I3MST1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

9615:FKBP6
gene id: 9615:FKBP6
uniprot id: A0A8C0SCN2
uniprot id: A0A8I3MRM0
names: Function
names: Similarity
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

9615:PSMD8
gene id: 9615:PSMD8
uniprot id: A0A8C0NGQ9
uniprot id: A0A8I3N165
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

9615:BDKRB2
gene id: 9615:BDKRB2
uniprot id: A0A8C0RFX5
uniprot id: Q9BDQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9615:MOCS2
gene id: 9615:MOCS2
uniprot id: A0A8C0QI15
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9615:B4GALNT3
gene id: 9615:B4GALNT3
uniprot id: A0A8P0NHD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

9615:TP63
gene id: 9615:TP63
uniprot id: A0A8C0P4Y6
uniprot id: A0A8C0RNE9
uniprot id: A0A8I3PKL5
uniprot id: A0A8P0T7X9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9615:SLC26A10
gene id: 9615:SLC26A10
uniprot id: A0A8C0SS99
uniprot id: A0A8I3NPA1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ABHD16A
gene id: 9615:ABHD16A
uniprot id: A0A8C0MGY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

9615:ISL1
gene id: 9615:ISL1
uniprot id: A0A8I3MB57
names: Subcellular Location Annotation
messages: Nucleus

9615:ACTG2
gene id: 9615:ACTG2
uniprot id: A0A8C0P2V8
uniprot id: A0A8I3PAR6
names: Similarity
messages: Belongs to the actin family.

9615:EIF2D
gene id: 9615:EIF2D
uniprot id: A0A8P0NCB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9615:SETD2
gene id: 9615:SETD2
uniprot id: A0A8C0PMS6
uniprot id: A0A8I3NCV7
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9615:GMPPA
gene id: 9615:GMPPA
uniprot id: A0A8C0NFS9
uniprot id: A0A8I3QXV7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9615:EPB41
gene id: 9615:EPB41
uniprot id: Q6Q7P4
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Binds calmodulin, CENPJ and DLG1. Also found to associate with contractile apparatus and tight junctions. Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes for anaphase-specific localization of NUMA1 in symmetrically dividing cells. Interacts with ATP2B1; regulates small intestinal calcium absorption through regulation of membrane expression of ATP2B1 (By similarity).
messages: Nucleus
messages: O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.
messages: Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
messages: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
messages: cell cortex
messages: cytoskeleton

9615:TMBIM6
gene id: 9615:TMBIM6
uniprot id: A0A8C0TLC2
uniprot id: A0A8P0PPC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9615:FGA
gene id: 9615:FGA
uniprot id: A0A8C0MTI9
uniprot id: A0A8P0NAN3
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9615:NME5
gene id: 9615:NME5
uniprot id: A0A8C0SGE5
uniprot id: A0A8I3P5U2
names: Similarity
messages: Belongs to the NDK family.

9615:BMP10
gene id: 9615:BMP10
uniprot id: A0A8C0P7W4
uniprot id: A0A8I3PPQ3
names: Similarity
messages: Belongs to the TGF-beta family.

9615:FOXJ2
gene id: 9615:FOXJ2
uniprot id: A0A8C0P4Z5
uniprot id: A0A8I3Q4X7
names: Subcellular Location Annotation
messages: Nucleus

9615:GRPEL2
gene id: 9615:GRPEL2
uniprot id: A0A8C0Q8E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9615:NTF4
gene id: 9615:NTF4
uniprot id: A0A8C0PL35
uniprot id: A0A8I3MVE7
names: Similarity
messages: Belongs to the NGF-beta family.

9615:IFNA7
gene id: 9615:IFNA7
uniprot id: A0A8C0TEL2
uniprot id: Q75UL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9615:ATP2C2
gene id: 9615:ATP2C2
uniprot id: A0A8C0LVL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:CWC15
gene id: 9615:CWC15
uniprot id: A0A8C0SUD4
uniprot id: A0A8I3P4E3
names: Similarity
messages: Belongs to the CWC15 family.

9615:FERMT1
gene id: 9615:FERMT1
uniprot id: A0A8C0QD59
names: Similarity
messages: Belongs to the kindlin family.

9615:TOMM40
gene id: 9615:TOMM40
uniprot id: A0A8C0RAS4
uniprot id: A0A8I3N267
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:SNX3
gene id: 9615:SNX3
uniprot id: A0A8C0MYJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

9615:AGBL5
gene id: 9615:AGBL5
uniprot id: A0A8C0MHM0
uniprot id: A0A8I3MVR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Midbody
messages: Nucleus
messages: cytosol
messages: spindle

9615:MACO1
gene id: 9615:MACO1
uniprot id: Q2TLZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Nucleus membrane
messages: Plays a role in the regulation of neuronal activity.
messages: Rough endoplasmic reticulum membrane

9615:FAM3D
gene id: 9615:FAM3D
uniprot id: A0A8C0NQ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9615:GIPR
gene id: 9615:GIPR
uniprot id: A0A8C0QLM4
names: Subcellular Location Annotation
messages: Membrane

9615:PITPNM1
gene id: 9615:PITPNM1
uniprot id: A0A8C0P6F2
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9615:LOC102152706
gene id: 9615:LOC102152706
uniprot id: A0A8C0S7Q9
uniprot id: A0A8I3PVX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9615:OLR1
gene id: 9615:OLR1
uniprot id: A0A8C0NTJ7
uniprot id: A0A8I3QC57
names: Subcellular Location Annotation
messages: Membrane

9615:P2RX5
gene id: 9615:P2RX5
uniprot id: A0A8I3NX68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9615:CCNI
gene id: 9615:CCNI
uniprot id: A0A8C0PAT7
uniprot id: A0A8I3S1G0
uniprot id: A0A8P0PI49
names: Similarity
messages: Belongs to the cyclin family.

9615:TAGLN2
gene id: 9615:TAGLN2
uniprot id: A0A8I3SCV9
names: Similarity
messages: Belongs to the calponin family.

9615:OR10A5
gene id: 9615:OR10A5
uniprot id: A0A8C0NCJ7
uniprot id: A0A8P0NSL2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:ACADVL
gene id: 9615:ACADVL
uniprot id: A0A8C0N881
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9615:SCNN1A
gene id: 9615:SCNN1A
uniprot id: A0A8C0PLX6
uniprot id: A0A8P0TEQ4
names: Subcellular Location Annotation
messages: Membrane

9615:HAPLN3
gene id: 9615:HAPLN3
uniprot id: A0A8P0SGF7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9615:ENTPD2
gene id: 9615:ENTPD2
uniprot id: A0A8C0SI87
uniprot id: A0A8I3PJZ3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:ME1
gene id: 9615:ME1
uniprot id: A0A8P0ST92
names: Similarity
messages: Belongs to the malic enzymes family.

9615:FAM114A1
gene id: 9615:FAM114A1
uniprot id: A0A8I3MPK4
names: Similarity
messages: Belongs to the FAM114 family.

9615:YPEL1
gene id: 9615:YPEL1
uniprot id: A0A8C0PK52
names: Similarity
messages: Belongs to the yippee family.

9615:SLC16A4
gene id: 9615:SLC16A4
uniprot id: A0A8C0SI36
uniprot id: A0A8I3MJS3
names: Subcellular Location Annotation
messages: Membrane

9615:HGF
gene id: 9615:HGF
uniprot id: Q867B7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity (By similarity).
messages: Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity).

9615:LCAT
gene id: 9615:LCAT
uniprot id: A0A8C0NJ18
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9615:LOC100855540
gene id: 9615:LOC100855540
uniprot id: A0A8C0MNB3
uniprot id: A0A8I3MJ33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9615:CNNM2
gene id: 9615:CNNM2
uniprot id: A0A8C0PBG9
uniprot id: A0A8C0TQH4
uniprot id: A0A8I3PSU6
uniprot id: A0A8I3PYS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9615:HSD3B2
gene id: 9615:HSD3B2
uniprot id: Q5IFP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (By similarity).
messages: Belongs to the 3-beta-HSD family.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane

9615:MED22
gene id: 9615:MED22
uniprot id: A0A8C0R9Y3
uniprot id: A0A8I3N7W6
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9615:LOC480600
gene id: 9615:LOC480600
uniprot id: A0A8C0NXT2
uniprot id: A0A8I3NLR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:PGK2
gene id: 9615:PGK2
uniprot id: A0A8C0Q3U2
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9615:CRYGB
gene id: 9615:CRYGB
uniprot id: A3RLE1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

9615:SUCLG2
gene id: 9615:SUCLG2
uniprot id: A0A8C0N738
uniprot id: A0A8C0S9C6
uniprot id: A0A8I3NE82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9615:DPH1
gene id: 9615:DPH1
uniprot id: A0A8C0Q0Q9
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.

9615:LOC609902
gene id: 9615:LOC609902
uniprot id: A0A8C0T824
names: Similarity
messages: Belongs to the FAM133 family.

9615:GALE
gene id: 9615:GALE
uniprot id: A0A8C0LY40
uniprot id: A0A8I3P3X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9615:SARS1
gene id: 9615:SARS1
uniprot id: A0A8C0MWB6
uniprot id: A0A8I3MPG2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9615:SULT1D1
gene id: 9615:SULT1D1
uniprot id: A0A8C0PRQ2
uniprot id: A0A8I3RXJ1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:SRSF1
gene id: 9615:SRSF1
uniprot id: A0A8C0TYS8
uniprot id: A0A8I3P1V7
names: Similarity
messages: Belongs to the splicing factor SR family.

9615:SPAST
gene id: 9615:SPAST
uniprot id: A0A8C0SH39
uniprot id: A0A8I3NPL4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

9615:ATP6V0A4
gene id: 9615:ATP6V0A4
uniprot id: A0A8C0NC39
uniprot id: A0A8I3ND81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9615:CASP10
gene id: 9615:CASP10
uniprot id: A0A8C0TGH3
uniprot id: A0A8I3SCI1
names: Similarity
messages: Belongs to the peptidase C14A family.

9615:PRSS23
gene id: 9615:PRSS23
uniprot id: A0A8P0TTA6
names: Similarity
messages: Belongs to the peptidase S1B family.

9615:SSR1
gene id: 9615:SSR1
uniprot id: P16967
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins (By similarity).
messages: Phosphorylated in its cytoplasmic tail.
messages: Seems to bind calcium.
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9615:SLC33A1
gene id: 9615:SLC33A1
uniprot id: A0A8I3PDC7
names: Subcellular Location Annotation
messages: Membrane

9615:SLC5A11
gene id: 9615:SLC5A11
uniprot id: A0A8C0PUK3
uniprot id: A0A8I3RR05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9615:ATG12
gene id: 9615:ATG12
uniprot id: A0A8C0SEB7
uniprot id: A0A8I3NBC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9615:LIN28B
gene id: 9615:LIN28B
uniprot id: A0A8C0QAA4
uniprot id: A0A8P0N6H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9615:SLC17A1
gene id: 9615:SLC17A1
uniprot id: A0A8C0P4J5
uniprot id: A0A8P0SFK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

9615:HIBADH
gene id: 9615:HIBADH
uniprot id: A0A8C0S5K4
uniprot id: A0A8P0S8Q1
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9615:GORASP1
gene id: 9615:GORASP1
uniprot id: A0A8C0T1G0
uniprot id: A0A8I3Q4E7
names: Similarity
messages: Belongs to the GORASP family.

9615:PTGER2
gene id: 9615:PTGER2
uniprot id: Q9XT82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle (By similarity).

9615:FUT9
gene id: 9615:FUT9
uniprot id: Q659L1
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by Mn2+.
messages: Belongs to the glycosyltransferase 10 family.
messages: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth. Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis. Furthermore, it is capable to synthesizes Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis. May also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.
messages: Golgi apparatus membrane
messages: N-glycosylated with complex-type N-glycans.
messages: trans-Golgi network membrane

9615:GEM
gene id: 9615:GEM
uniprot id: A0A8C0P6W9
uniprot id: A0A8I3NVP2
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9615:PTPRU
gene id: 9615:PTPRU
uniprot id: A0A8I3MW46
uniprot id: A0A8I3N6Z2
uniprot id: A0A8P0PF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9615:DEFB105A
gene id: 9615:DEFB105A
uniprot id: F1PK37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:E2F8
gene id: 9615:E2F8
uniprot id: A0A8C0PIG7
uniprot id: A0A8I3P386
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9615:GFRA1
gene id: 9615:GFRA1
uniprot id: A0A8C0TV81
uniprot id: A0A8I3QCB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9615:SPTSSB
gene id: 9615:SPTSSB
uniprot id: A0A8C0TGY7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:DNAJB14
gene id: 9615:DNAJB14
uniprot id: A0A8C0RQR0
uniprot id: A0A8I3PXR8
names: Subcellular Location Annotation
messages: Membrane

9615:MPP1
gene id: 9615:MPP1
uniprot id: A0A8I3Q2L6
uniprot id: F1PFU5
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

9615:INSL3
gene id: 9615:INSL3
uniprot id: Q6X7V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: More strongly expressed in testis than in ovary.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).

9615:XKR8
gene id: 9615:XKR8
uniprot id: A0A8I3NGB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9615:OTX1
gene id: 9615:OTX1
uniprot id: A0A8C0RXS0
uniprot id: A0A8I3NZB7
names: Subcellular Location Annotation
messages: Nucleus

9615:TAS2R38
gene id: 9615:TAS2R38
uniprot id: Q2ABD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9615:PTHLH
gene id: 9615:PTHLH
uniprot id: P52211
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity).
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity).

9615:MCOLN1
gene id: 9615:MCOLN1
uniprot id: A0A8C0PCC1
uniprot id: A0A8P0T8W5
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9615:CDA
gene id: 9615:CDA
uniprot id: A0A8C0MP51
uniprot id: A0A8I3MFS9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

9615:KXD1
gene id: 9615:KXD1
uniprot id: A0A8C0NF04
uniprot id: A0A8I3S237
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9615:DYRK4
gene id: 9615:DYRK4
uniprot id: A0A8I3QBY9
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9615:HNRNPD
gene id: 9615:HNRNPD
uniprot id: A0A8C0NEC1
uniprot id: A0A8C0NGU7
uniprot id: A0A8C0TJC8
uniprot id: A0A8I3P1C5
uniprot id: A0A8I3P1F3
uniprot id: A0A8I3P7D1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:CD5L
gene id: 9615:CD5L
uniprot id: W8VYQ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MAT1A
gene id: 9615:MAT1A
uniprot id: A0A8C0Z6S2
uniprot id: A0A8I3NL28
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9615:SERPINA6
gene id: 9615:SERPINA6
uniprot id: A0A8P0SLZ3
names: Similarity
messages: Belongs to the serpin family.

9615:CSNK1G1
gene id: 9615:CSNK1G1
uniprot id: A0A8C0NRC3
uniprot id: A0A8C0NSZ5
uniprot id: A0A8C0TNJ8
uniprot id: A0A8I3PHC8
uniprot id: A0A8I3PLM5
uniprot id: A0A8I3PLQ1
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9615:RAD17
gene id: 9615:RAD17
uniprot id: A0A8P0SD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9615:FARSA
gene id: 9615:FARSA
uniprot id: A0A8C0P139
uniprot id: A0A8I3NX27
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

9615:WWOX
gene id: 9615:WWOX
uniprot id: A0A8C0RAF0
uniprot id: A0A8C0S3P8
uniprot id: A0A8I3PBQ7
uniprot id: A0A8I3PHM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9615:FGF12
gene id: 9615:FGF12
uniprot id: A0A8C0NL09
uniprot id: A0A8C0TAM1
uniprot id: A0A8I3PPX4
uniprot id: J9P2J7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:ADCY8
gene id: 9615:ADCY8
uniprot id: A0A8C0T467
uniprot id: A0A8C0T647
uniprot id: A0A8C0Z1L3
uniprot id: A0A8I3NFX0
uniprot id: A0A8I3NUA5
uniprot id: A0A8I3NUB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9615:TMEM63C
gene id: 9615:TMEM63C
uniprot id: A0A8C0YZU5
uniprot id: A0A8I3MSB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9615:KDM1A
gene id: 9615:KDM1A
uniprot id: A0A8C0M261
uniprot id: A0A8C0PWR1
uniprot id: A0A8I3MA21
uniprot id: A0A8I3RNY9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

9615:SEC24A
gene id: 9615:SEC24A
uniprot id: A0A8C0QG40
uniprot id: A0A8I3NPS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9615:FAM76B
gene id: 9615:FAM76B
uniprot id: A0A8C0NYY5
names: Similarity
messages: Belongs to the FAM76 family.

9615:AIFM1
gene id: 9615:AIFM1
uniprot id: A0A8C0MTD8
uniprot id: A0A8C0TCT2
uniprot id: A0A8I3SCX0
uniprot id: A0A8P0P6X8
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9615:METAP2
gene id: 9615:METAP2
uniprot id: A0A8C0N942
uniprot id: A0A8C0QH43
uniprot id: A0A8I3PF51
uniprot id: A0A8I3S7G5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9615:GGACT
gene id: 9615:GGACT
uniprot id: A0A8C0MH61
uniprot id: A0A8I3PIL7
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9615:AFP
gene id: 9615:AFP
uniprot id: Q8MJU5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin.
messages: Dimeric and trimeric forms have been found in addition to the monomeric form.
messages: Plasma.
messages: Secreted
messages: Sulfated.

9615:CTSD
gene id: 9615:CTSD
uniprot id: Q4LAL9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.
messages: Belongs to the peptidase A1 family.
messages: Consists of a light chain and a heavy chain. Interacts with ADAM30; this leads to activation of CTSD. Interacts with GRN; stabilizes CTSD; increases its proteolytic activity (By similarity).
messages: Lysosome
messages: Melanosome
messages: N- and O-glycosylated.
messages: Undergoes proteolytic cleavage and activation by ADAM30.
messages: extracellular space

9615:ESCO2
gene id: 9615:ESCO2
uniprot id: A0A8P0NPE5
names: Subcellular Location Annotation
messages: Nucleus

9615:RNF8
gene id: 9615:RNF8
uniprot id: A0A8C0T933
uniprot id: A0A8P0S7J0
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9615:NDUFB11
gene id: 9615:NDUFB11
uniprot id: A0A8C0SUT5
uniprot id: A0A8I3Q1H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:HSPA13
gene id: 9615:HSPA13
uniprot id: A0A8C0TY86
uniprot id: J9NU25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

9615:DOC2A
gene id: 9615:DOC2A
uniprot id: A0A8C0SVD1
uniprot id: A0A8I3MHK4
uniprot id: A0A8I3MKJ8
names: Subcellular Location Annotation
messages: Membrane

9615:CCL20
gene id: 9615:CCL20
uniprot id: A0A8C0PBJ7
uniprot id: Q68AP1
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9615:CD63
gene id: 9615:CD63
uniprot id: A0A8C0NFC7
uniprot id: A0A8I3N083
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9615:SFR1
gene id: 9615:SFR1
uniprot id: A0A8C0PDC7
uniprot id: A0A8P0P9H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9615:MCU
gene id: 9615:MCU
uniprot id: A0A8C0MXD8
uniprot id: A0A8I3N0W5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9615:DES
gene id: 9615:DES
uniprot id: Q5XFN2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylation prevents ability to form intermediate filaments.
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Homomer (PubMed:24413773). Interacts with DST (By similarity). Interacts with MTM1 (By similarity). Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament (By similarity). Interacts with CRYAB (By similarity). Interacts with NEB (via nebulin repeats 160-164) (By similarity). Interacts (via rod region) with NEBL (via nebulin repeats 1-5) (By similarity). Interacts with ASB2; the interaction targets DES for proteasomal degradation (By similarity). Interacts with PKP1 (By similarity).
messages: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin.
messages: Nucleus
messages: Phosphorylation at Ser-7, Ser-28 and Ser-32 by CDK1, phosphorylation at Ser-60 by AURKB and phosphorylation at Thr-76 by ROCK1 contribute to efficient separation of desmin intermediate filaments during mitosis.
messages: Ubiquitination by a SCF-like complex containing ASB2 leads to proteasomal degradation.
messages: Z line
messages: sarcolemma

9615:ESS2
gene id: 9615:ESS2
uniprot id: A0A8I3S7G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9615:OPN1SW
gene id: 9615:OPN1SW
uniprot id: A0A8C0PGR1
uniprot id: A0A8I3PJU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9615:AKAP9
gene id: 9615:AKAP9
uniprot id: A0A8C0T1Z5
names: Subcellular Location Annotation
messages: centrosome

9615:GDF15
gene id: 9615:GDF15
uniprot id: A0A8C0TNP6
uniprot id: A0A8P0NGD1
names: Similarity
messages: Belongs to the TGF-beta family.

9615:EPHA2
gene id: 9615:EPHA2
uniprot id: A0A286R219
names: Subcellular Location Annotation
messages: Membrane

9615:ENTPD6
gene id: 9615:ENTPD6
uniprot id: A0A8I3PYT2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:SLC25A13
gene id: 9615:SLC25A13
uniprot id: A0A8C0SP45
uniprot id: A0A8I3S503
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:MKRN2
gene id: 9615:MKRN2
uniprot id: A0A8C0TDW1
uniprot id: A0A8C0TGL6
uniprot id: A0A8I3PYL3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:NSUN6
gene id: 9615:NSUN6
uniprot id: A0A8C0MXM1
uniprot id: A0A8I3NEZ3
uniprot id: A0A8I3RXD1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:PFDN1
gene id: 9615:PFDN1
uniprot id: A0A8C0Q9N4
uniprot id: A0A8I3MY97
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9615:WFDC2
gene id: 9615:WFDC2
uniprot id: Q28894
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Broad range protease inhibitor (By similarity). Possible function in sperm maturation.
messages: Epididymis. Highest levels are found in the caput and proximal cauda regions. Lower levels in the distal cauda. Not detected in the efferent ducts.
messages: Homotrimer; disulfide-linked.
messages: Secreted

9615:CPT1C
gene id: 9615:CPT1C
uniprot id: A0A8C0SVR6
uniprot id: A0A8I3PFF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:GTPBP3
gene id: 9615:GTPBP3
uniprot id: A0A8C0YYM8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9615:ROS1
gene id: 9615:ROS1
uniprot id: A0A8C0N5K2
uniprot id: A0A8C0RJM1
uniprot id: A0A8P0P389
uniprot id: A0A8P0S6W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9615:AURKA
gene id: 9615:AURKA
uniprot id: A0A8P0NQ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9615:NPRL2
gene id: 9615:NPRL2
uniprot id: A0A8C0N1K0
uniprot id: A0A8C0NAB9
uniprot id: A0A8I3P781
uniprot id: A0A8I3PM87
names: Similarity
messages: Belongs to the NPR2 family.

9615:RPS6KB2
gene id: 9615:RPS6KB2
uniprot id: A0A8C0P2H0
uniprot id: A0A8P0NDH1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9615:ANAPC16
gene id: 9615:ANAPC16
uniprot id: A0A8C0PSW9
uniprot id: A0A8I3MRF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9615:NLGN2
gene id: 9615:NLGN2
uniprot id: A0A8C0QEZ2
uniprot id: A0A8I3PDM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9615:TNFRSF1B
gene id: 9615:TNFRSF1B
uniprot id: A0A8C0Q928
uniprot id: A0A8I3MDX6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RP2
gene id: 9615:RP2
uniprot id: A0A8C0SVX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9615:MRPS9
gene id: 9615:MRPS9
uniprot id: A0A8I3NF66
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9615:NAPG
gene id: 9615:NAPG
uniprot id: A0A8C0MDB0
uniprot id: A0A8I3MT73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9615:NPTX2
gene id: 9615:NPTX2
uniprot id: A0A8P0NH47
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CADM3
gene id: 9615:CADM3
uniprot id: A0A8C0NGL7
uniprot id: A0A8I3NXI6
names: Similarity
messages: Belongs to the nectin family.

9615:SLC10A2
gene id: 9615:SLC10A2
uniprot id: A0A8C0TWY6
uniprot id: Q70HQ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

9615:NKX2-2
gene id: 9615:NKX2-2
uniprot id: A0A8C0RQT7
uniprot id: A0A8I3SAT7
names: Subcellular Location Annotation
messages: Nucleus

9615:ACSL5
gene id: 9615:ACSL5
uniprot id: A0A8C0NSC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9615:ADGRL1
gene id: 9615:ADGRL1
uniprot id: A0A8I3PTG8
names: Subcellular Location Annotation
messages: Membrane

9615:ENTPD7
gene id: 9615:ENTPD7
uniprot id: A0A8C0NXB4
uniprot id: A0A8I3QPY0
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9615:YAE1
gene id: 9615:YAE1
uniprot id: A0A8C0M7W8
uniprot id: A0A8I3PAT7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9615:S1PR2
gene id: 9615:S1PR2
uniprot id: A0A8C0P6J2
uniprot id: A0A8I3P3I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9615:TMPRSS5
gene id: 9615:TMPRSS5
uniprot id: A0A8C0Q0E7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:P2RX4
gene id: 9615:P2RX4
uniprot id: A0A8C0PER1
uniprot id: A0A8I3Q0A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9615:PSMB1
gene id: 9615:PSMB1
uniprot id: A0A8C0N5D2
uniprot id: A0A8I3PKH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:TARS1
gene id: 9615:TARS1
uniprot id: A0A8I3MZD1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9615:TMCO1
gene id: 9615:TMCO1
uniprot id: A0A8I3PI99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.
messages: Membrane

9615:HEXA
gene id: 9615:HEXA
uniprot id: A0A8C0SV52
uniprot id: A0A8I3PNW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9615:MAOA
gene id: 9615:MAOA
uniprot id: P58027
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

9615:MPZ
gene id: 9615:MPZ
uniprot id: A0A8I3Q1X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Homodimer and homotetramer.
messages: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
messages: Membrane

9615:GRK7
gene id: 9615:GRK7
uniprot id: A0A8C0M4L1
uniprot id: A0A8I3PWQ2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9615:PDGFD
gene id: 9615:PDGFD
uniprot id: A0A8C0SPQ7
uniprot id: A0A8I3MGR1
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:RPA2
gene id: 9615:RPA2
uniprot id: A0A8P0TDG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 2 family.
messages: Nucleus

9615:F2
gene id: 9615:F2
uniprot id: A0A8C0PX10
uniprot id: A0A8I3PUT1
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

9615:MAPRE3
gene id: 9615:MAPRE3
uniprot id: A0A8C0MH41
uniprot id: A0A8I3N134
uniprot id: A0A8I3N1W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9615:MRPS23
gene id: 9615:MRPS23
uniprot id: A0A8P0T3G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

9615:LOC100685875
gene id: 9615:LOC100685875
uniprot id: A0A8C0T262
uniprot id: A0A8I3PK03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9615:GNAS
gene id: 9615:GNAS
uniprot id: P63091
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(s) subfamily.
messages: Cell membrane
messages: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
messages: Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with CRY1; the interaction may block GPCR-mediated regulation of cAMP concentrations. Interacts with ADCY6 and stimulates its adenylyl cyclase activity (By similarity). Interacts with ADCY2 and ADCY5 (By similarity). Stimulates the ADCY5 adenylyl cyclase activity (By similarity). Interaction with SASH1 (By similarity).

9615:CYP3A26
gene id: 9615:CYP3A26
uniprot id: Q8HZK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9615:PCID2
gene id: 9615:PCID2
uniprot id: A0A8C0S4B1
uniprot id: A0A8C0S4J5
uniprot id: A0A8I3S898
uniprot id: A0A8P0P7E9
names: Similarity
messages: Belongs to the CSN12 family.

9615:LOC477518
gene id: 9615:LOC477518
uniprot id: Q2KM14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9615:UBE2D1
gene id: 9615:UBE2D1
uniprot id: A0A8C0RUB4
uniprot id: A0A8I3MLM6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9615:DDX55
gene id: 9615:DDX55
uniprot id: A0A8C0TNV1
uniprot id: A0A8I3S2J2
names: Similarity
messages: Belongs to the DEAD box helicase family.

9615:ADPRS
gene id: 9615:ADPRS
uniprot id: A0A8C0NSF6
uniprot id: A0A8I3SCV6
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9615:OR8U8
gene id: 9615:OR8U8
uniprot id: A0A8C0SQZ4
uniprot id: A0A8I3RT47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SCGB1C1
gene id: 9615:SCGB1C1
uniprot id: A0A8C0TI14
uniprot id: A0A8I3QFJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9615:CCDC56
gene id: 9615:CCDC56
uniprot id: A0A8C0T9Q4
uniprot id: A0A8I3N8V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9615:KIAA2013
gene id: 9615:KIAA2013
uniprot id: A0A8C0NXH3
uniprot id: A0A8I3RRT8
names: Subcellular Location Annotation
messages: Membrane

9615:TIRAP
gene id: 9615:TIRAP
uniprot id: A0A8I3NN38
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

9615:TK1
gene id: 9615:TK1
uniprot id: A0A8C0NFL6
uniprot id: A0A8I3S154
names: Similarity
messages: Belongs to the thymidine kinase family.

9615:GNG5
gene id: 9615:GNG5
uniprot id: A0A8C0YWB5
uniprot id: A0A8I3RRM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9615:SLITRK6
gene id: 9615:SLITRK6
uniprot id: A0A8C0M9K6
names: Similarity
messages: Belongs to the SLITRK family.

9615:CD164
gene id: 9615:CD164
uniprot id: A0A8C0MRV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9615:PIK3CG
gene id: 9615:PIK3CG
uniprot id: A0A8C0RPI8
uniprot id: A0A8P0PAL1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9615:PDE7A
gene id: 9615:PDE7A
uniprot id: A0A8C0T5T8
uniprot id: A0A8I3S384
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:CHST8
gene id: 9615:CHST8
uniprot id: A0A8C0QDC5
uniprot id: A0A8I3MJR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:FGF14
gene id: 9615:FGF14
uniprot id: A0A8C0M8L5
uniprot id: A0A8I3PYP1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:CMC4
gene id: 9615:CMC4
uniprot id: A0A8C0TDT8
uniprot id: A0A8I3Q378
names: Similarity
messages: Belongs to the CMC4 family.

9615:LTA
gene id: 9615:LTA
uniprot id: A0A0U5J7M4
uniprot id: Q5WR07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo (By similarity).
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9615:SNRPE
gene id: 9615:SNRPE
uniprot id: A0A8C0RIK2
uniprot id: A0A8I3PBM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9615:MRPS31
gene id: 9615:MRPS31
uniprot id: A0A8C0NTF3
uniprot id: A0A8I3S469
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9615:TSEN34
gene id: 9615:TSEN34
uniprot id: A0A8C0LWZ6
uniprot id: A0A8I3RT24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9615:CYP1B1
gene id: 9615:CYP1B1
uniprot id: C1KG39
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:AMOTL2
gene id: 9615:AMOTL2
uniprot id: A0A8I3QA39
names: Similarity
messages: Belongs to the angiomotin family.

9615:GUCA2B
gene id: 9615:GUCA2B
uniprot id: A0A8C0S8A9
uniprot id: A0A8P0S8D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9615:ATP6V1E1
gene id: 9615:ATP6V1E1
uniprot id: A0A8C0T1Z7
uniprot id: A0A8I3QBE3
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9615:EFNA5
gene id: 9615:EFNA5
uniprot id: A0A8C0MWS8
uniprot id: A0A8C0SCQ5
uniprot id: A0A8I3MD88
uniprot id: A0A8I3RQW1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:EIF2B2
gene id: 9615:EIF2B2
uniprot id: A0A8C0SJF8
uniprot id: A0A8I3NV56
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9615:PACC1
gene id: 9615:PACC1
uniprot id: A0A8C0PXB7
uniprot id: A0A8I3RRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9615:PMCH
gene id: 9615:PMCH
uniprot id: Q5XXR2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the melanin-concentrating hormone family.
messages: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal.
messages: Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6 (By similarity).
messages: Secreted

9615:PIM1
gene id: 9615:PIM1
uniprot id: A0A8C0N5V7
uniprot id: A0A8I3RY15
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9615:GBE1
gene id: 9615:GBE1
uniprot id: A0A8C0TJQ5
uniprot id: A0A8I3P5A5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

9615:CCL7
gene id: 9615:CCL7
uniprot id: Q5KSU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9615:ACTR10
gene id: 9615:ACTR10
uniprot id: A0A8C0RWH2
uniprot id: A0A8I3NZT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9615:ABCB11
gene id: 9615:ABCB11
uniprot id: B8K1W2
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
messages: Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:18985798). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (By similarity).
messages: Cell membrane
messages: Endosome
messages: Interacts with HAX1 (By similarity). Interacts with the adapter protein complex 2 (AP-2) throught AP2A2 or AP2A1; this interaction regulates cell membrane expression of ABCB11 through its internalization in a clathrin-dependent manner and its subsequent degradation (By similarity).
messages: Liver.
messages: N-glycosylated.
messages: Recycling endosome membrane
messages: The uptake of taurocholate is inhibited by taurolithocholate sulfate with an IC(50) of 9 uM. Pravastatin competitively inhibits the transport of taurocholic acid (PubMed:18985798). Cyclosporin A, glibenclamide, rifampicin and troglitazonestrongly competitively inhibit the transport activity of taurocholate (PubMed:18985798). The canalicular transport activity of taurocholate is strongly dependent on canalicular membrane cholesterol content. The uptake of taurocholate is increased by short- and medium-chain fatty acids. Cholesterol increases transport capacity of taurocholate without affecting the affinity for the substrate (By similarity).
messages: Ubiquitinated; short-chain ubiquitination regulates cell-Surface expression of ABCB11.

9615:NGF
gene id: 9615:NGF
uniprot id: A0A8C0MBJ0
uniprot id: A0A8I3PYI3
uniprot id: Q531B0
uniprot id: Q702P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted

9615:OR9A4C
gene id: 9615:OR9A4C
uniprot id: E2RSV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:STOM
gene id: 9615:STOM
uniprot id: A0A8C0NIZ2
uniprot id: B6F250
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9615:GLIPR1
gene id: 9615:GLIPR1
uniprot id: A0A8I3PMT8
names: Similarity
messages: Belongs to the CRISP family.

9615:HOXA5
gene id: 9615:HOXA5
uniprot id: A0A8C0MH05
uniprot id: A0A8I3N8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:NEFL
gene id: 9615:NEFL
uniprot id: A0A8C0TAX3
uniprot id: A0A8I3NI39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: cytoskeleton

9615:EID1
gene id: 9615:EID1
uniprot id: A0A8I3PH56
names: Subcellular Location Annotation
messages: Nucleus

9615:DCBLD2
gene id: 9615:DCBLD2
uniprot id: A0A8I3S2H8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:SAE1
gene id: 9615:SAE1
uniprot id: A0A8C0Q9T2
uniprot id: A0A8I3MIJ2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9615:LOC102155967
gene id: 9615:LOC102155967
uniprot id: A0A8C0RZI9
uniprot id: A0A8I3PIY0
names: Similarity
messages: Belongs to the MS4A family.

9615:CDX1
gene id: 9615:CDX1
uniprot id: A0A8C0M6U4
uniprot id: A0A8P0NJB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9615:MAPK1
gene id: 9615:MAPK1
uniprot id: A0A8C0TIJ2
uniprot id: A0A8I3PZP0
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola

9615:STIM1
gene id: 9615:STIM1
uniprot id: A0A8C0RP45
uniprot id: A0A8C0TIM1
uniprot id: A0A8I3NFR6
uniprot id: A0A8I3NK53
uniprot id: A0A8I3RWM0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:PPCS
gene id: 9615:PPCS
uniprot id: A0A8C0S6E6
uniprot id: A0A8I3P9M0
names: Similarity
messages: Belongs to the PPC synthetase family.

9615:CCDC85B
gene id: 9615:CCDC85B
uniprot id: A0A8C0SQY2
uniprot id: A0A8I3P0N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9615:SRP14
gene id: 9615:SRP14
uniprot id: P16255
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6938958). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:6938958, PubMed:6413076). The complex of SRP9 and SRP14 is required for SRP RNA binding (PubMed:6938958, PubMed:6413076).
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer (PubMed:6413076). Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6938958, PubMed:6413076).

9615:TMPRSS15
gene id: 9615:TMPRSS15
uniprot id: A0A8P0NAR8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMBT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:NR0B2
gene id: 9615:NR0B2
uniprot id: A0A8I3NE48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9615:TNFRSF1A
gene id: 9615:TNFRSF1A
uniprot id: A0A8C0TE64
uniprot id: A0A8P0NH02
uniprot id: A0A8P0PBA6
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:ZNF592
gene id: 9615:ZNF592
uniprot id: A0A8P0SX79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9615:KCNH8
gene id: 9615:KCNH8
uniprot id: A0A8C0PLC3
uniprot id: A0A8I3PNB9
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9615:ABL2
gene id: 9615:ABL2
uniprot id: A0A8C0M9X3
uniprot id: A0A8I3MZC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9615:GATC
gene id: 9615:GATC
uniprot id: A0A8C0T6Y4
uniprot id: A0A8I3Q2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9615:HTR2B
gene id: 9615:HTR2B
uniprot id: Q50DZ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via C-terminus) with MPDZ.
messages: Membrane
messages: synaptosome

9615:HINT1
gene id: 9615:HINT1
uniprot id: A0A8C0RQ83
uniprot id: A0A8I3RVN4
names: Similarity
messages: Belongs to the HINT family.

9615:GPNMB
gene id: 9615:GPNMB
uniprot id: A0A8C0RZN5
uniprot id: A0A8P0N5R9
names: Similarity
messages: Belongs to the PMEL/NMB family.

9615:LGI4
gene id: 9615:LGI4
uniprot id: A0A8C0RB02
names: Subcellular Location Annotation
messages: Secreted

9615:TMEM267
gene id: 9615:TMEM267
uniprot id: A0A8C0MF10
uniprot id: A0A8I3MEF8
names: Subcellular Location Annotation
messages: Membrane

9615:MRPS18C
gene id: 9615:MRPS18C
uniprot id: A0A8P0PAQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9615:OR51G4
gene id: 9615:OR51G4
uniprot id: G3FJF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:CDO1
gene id: 9615:CDO1
uniprot id: A0A8C0PJC2
uniprot id: A0A8I3MNS9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9615:EHD4
gene id: 9615:EHD4
uniprot id: A0A8C0SCG2
uniprot id: A0A8I3Q6L5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9615:MAP2K5
gene id: 9615:MAP2K5
uniprot id: A0A8C0MYZ5
uniprot id: A0A8C0TXV1
uniprot id: A0A8I3NYD3
uniprot id: A0A8I3P4L6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:ATF4
gene id: 9615:ATF4
uniprot id: A0A8C0NR73
uniprot id: A0A8I3PFQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9615:NAV1
gene id: 9615:NAV1
uniprot id: A0A8C0LVJ7
uniprot id: A0A8I3NSM0
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9615:ALKBH8
gene id: 9615:ALKBH8
uniprot id: A0A8C0SHI8
uniprot id: A0A8P0NGG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

9615:NRDC
gene id: 9615:NRDC
uniprot id: A0A8C0S4K6
names: Similarity
messages: Belongs to the peptidase M16 family.

9615:ASF1A
gene id: 9615:ASF1A
uniprot id: A0A8C0RXM1
uniprot id: A0A8I3NGT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9615:CCN1
gene id: 9615:CCN1
uniprot id: A0A8C0NHU0
uniprot id: A0A8I3S8V0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:ATP5MC3
gene id: 9615:ATP5MC3
uniprot id: A0A8C0SWP7
uniprot id: A0A8I3PAW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9615:C8B
gene id: 9615:C8B
uniprot id: A0A8C0LYP7
uniprot id: A0A8P0NJT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:PSMF1
gene id: 9615:PSMF1
uniprot id: A0A8C0MQ36
uniprot id: A0A8C0T7T9
uniprot id: A0A8P0P9N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9615:DLD
gene id: 9615:DLD
uniprot id: P49819
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer. Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDHA (PDHA1 or PDHA2) and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (by non covalent bonds). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with PDHX.
messages: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: The active site is a redox-active disulfide bond.
messages: Tyrosine phosphorylated.
messages: acrosome
messages: flagellum

9615:MDH1B
gene id: 9615:MDH1B
uniprot id: A0A8C0TZE0
uniprot id: A0A8I3PH80
uniprot id: A0A8P0SI95
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9615:PTGER4
gene id: 9615:PTGER4
uniprot id: A0A8C0M453
uniprot id: Q9TU16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9615:FTO
gene id: 9615:FTO
uniprot id: A0A8I3MHQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fto family.
messages: Cytoplasm
messages: Nucleus speckle

9615:FGF22
gene id: 9615:FGF22
uniprot id: A0A8C0PBB6
uniprot id: A0A8I3NYK3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9615:OPTC
gene id: 9615:OPTC
uniprot id: P83286
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Homodimer.
messages: Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).
messages: O-glycosylated.
messages: Ocular tissues, cartilage, ligament, skin, muscle and testes.
messages: Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5 (By similarity). Proteolytically cleaved by MMP13 (By similarity).
messages: Sulfated on tyrosine residues.
messages: extracellular matrix

9615:STK11IP
gene id: 9615:STK11IP
uniprot id: A0A8I3S7N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

9615:OR6C74
gene id: 9615:OR6C74
uniprot id: A0A8C0NTI3
uniprot id: F1Q4H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:DLA-64
gene id: 9615:DLA-64
uniprot id: O46881
names: Similarity
messages: Belongs to the MHC class I family.

9615:BORCS7
gene id: 9615:BORCS7
uniprot id: A0A8C0TN89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Membrane

9615:GDF10
gene id: 9615:GDF10
uniprot id: A0A8I3N6I7
names: Similarity
messages: Belongs to the TGF-beta family.

9615:DBP
gene id: 9615:DBP
uniprot id: A0A8C0NCM5
uniprot id: A0A8I3MHJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9615:RIPOR2
gene id: 9615:RIPOR2
uniprot id: A0A8C0TRR1
uniprot id: A0A8I3PJH4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: stereocilium membrane

9615:LOC100686103
gene id: 9615:LOC100686103
uniprot id: A0A8C0S4Y9
uniprot id: J9NZS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9615:LIPG
gene id: 9615:LIPG
uniprot id: A0A8C0LYV5
uniprot id: A0A8P0TGG9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9615:LIN54
gene id: 9615:LIN54
uniprot id: A0A8C0N340
uniprot id: A0A8I3S239
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9615:SLC35F1
gene id: 9615:SLC35F1
uniprot id: A0A8C0Q3T9
uniprot id: A0A8I3NFB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9615:MED30
gene id: 9615:MED30
uniprot id: A0A8C0M796
uniprot id: A0A8I3NTS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9615:USP7
gene id: 9615:USP7
uniprot id: A0A8C0Q8T7
uniprot id: A0A8C0RG53
uniprot id: A0A8I3NFM5
names: Similarity
messages: Belongs to the peptidase C19 family.

9615:CA2
gene id: 9615:CA2
uniprot id: A0A8C0MRL0
uniprot id: A0A8I3P3N6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9615:LOC485869
gene id: 9615:LOC485869
uniprot id: A0A8C0T6S1
uniprot id: A0A8I3S716
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

9615:LGR6
gene id: 9615:LGR6
uniprot id: A0A8P0SFC4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:TOMM7
gene id: 9615:TOMM7
uniprot id: A0A8C0PNC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9615:DEFB124
gene id: 9615:DEFB124
uniprot id: A0A8C0TGW6
uniprot id: Q30KT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9615:VANGL1
gene id: 9615:VANGL1
uniprot id: A0A8C0MBQ8
uniprot id: A0A8I3Q337
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9615:PPP1R1C
gene id: 9615:PPP1R1C
uniprot id: A0A8C0MPX7
uniprot id: A0A8I3NWG8
uniprot id: A0A8P0TS63
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9615:SLC5A3
gene id: 9615:SLC5A3
uniprot id: P31637
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Brain and kidney.
messages: Medium hypertonicity.
messages: Membrane
messages: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.

9615:LOC609321
gene id: 9615:LOC609321
uniprot id: A0A8C0MR72
uniprot id: A0A8I3MT57
uniprot id: A0A8I3ND11
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9615:RHAG
gene id: 9615:RHAG
uniprot id: Q3BCQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Heterotetramer.
messages: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport.
messages: Membrane

9615:DHRS3
gene id: 9615:DHRS3
uniprot id: A0A8C0MHF6
uniprot id: A0A8I3MI27
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:FAM207A
gene id: 9615:FAM207A
uniprot id: A0A8C0PEE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

9615:HCRTR2
gene id: 9615:HCRTR2
uniprot id: Q9TUP7
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Defects in HCRTR2 are a cause of an autosomal recessive form of narcolepsy, observed in labradors, dobermans and dachshunds. Narcolepsy is a neurological sleep disorder affecting animals and humans, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. As in humans, most cases of canine narcolepsy are sporadic but an autosomal recessive form was also observed.
messages: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
messages: The N-terminal region is required for orexin signaling.

9615:SEC23A
gene id: 9615:SEC23A
uniprot id: A0A8C0M9S2
uniprot id: A0A8I3RR85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9615:BLM
gene id: 9615:BLM
uniprot id: A0A8C0RAG2
uniprot id: A0A8I3MFB9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9615:PTGER3
gene id: 9615:PTGER3
uniprot id: Q6VPS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9615:SLC2A3
gene id: 9615:SLC2A3
uniprot id: P47842
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Deoxyglucose transport is inhibit by D-glucose, D-galactose and maltose. Galactose transport is inhibited by D-glucose and maltose.
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9615:SQLE
gene id: 9615:SQLE
uniprot id: A0A8C0MWQ3
uniprot id: A0A8I3NFI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9615:EHD1
gene id: 9615:EHD1
uniprot id: A0A8I3Q0J5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9615:KCNMA1
gene id: 9615:KCNMA1
uniprot id: Q28265
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Cell membrane
messages: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation (By similarity).
messages: Expressed in all vascular and smooth muscles.
messages: Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity. Interacts with RAB11B (By similarity).
messages: Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network (By similarity).
messages: Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity (By similarity).
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity).
messages: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).
messages: The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4.
messages: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensors regions required for activation of the channel (By similarity).
messages: The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation (By similarity).
messages: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).
messages: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca(2+) and Mg(2+).

9615:SNAPIN
gene id: 9615:SNAPIN
uniprot id: A0A8C0Q5P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9615:DYM
gene id: 9615:DYM
uniprot id: A0A8I3P124
names: Similarity
messages: Belongs to the dymeclin family.

9615:DDX51
gene id: 9615:DDX51
uniprot id: A0A8C0T5K5
uniprot id: A0A8I3PYL7
names: Similarity
messages: Belongs to the DEAD box helicase family.

9615:COQ7
gene id: 9615:COQ7
uniprot id: A0A8P0SM97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9615:NEMF
gene id: 9615:NEMF
uniprot id: A0A8C0LUQ6
uniprot id: A0A8I3MFD7
names: Similarity
messages: Belongs to the NEMF family.

9615:TWF1
gene id: 9615:TWF1
uniprot id: A0A8C0TGD9
uniprot id: A0A8I3QIT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9615:PPM1K
gene id: 9615:PPM1K
uniprot id: A0A8C0PKQ9
uniprot id: A0A8I3NQV5
names: Similarity
messages: Belongs to the PP2C family.

9615:HOPX
gene id: 9615:HOPX
uniprot id: A0A8C0P0L6
uniprot id: A0A8I3NLV8
names: Subcellular Location Annotation
messages: Nucleus

9615:SHH
gene id: 9615:SHH
uniprot id: A0A8C0NU16
uniprot id: A0A8I3NQ51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9615:PDGFRL
gene id: 9615:PDGFRL
uniprot id: A0A8C0QHQ6
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Secreted

9615:RAD51D
gene id: 9615:RAD51D
uniprot id: A0A8I3NE17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

9615:DLGAP5
gene id: 9615:DLGAP5
uniprot id: A0A8C0PUJ6
uniprot id: A0A8I3S1A6
names: Similarity
messages: Belongs to the SAPAP family.

9615:TMEM254
gene id: 9615:TMEM254
uniprot id: A0A8P0TNP8
names: Subcellular Location Annotation
messages: Membrane

9615:NFXL1
gene id: 9615:NFXL1
uniprot id: A0A8C0RJP0
uniprot id: A0A8I3RV90
names: Similarity
messages: Belongs to the NFX1 family.

9615:ZC2HC1C
gene id: 9615:ZC2HC1C
uniprot id: A0A8C0SKA2
names: Similarity
messages: Belongs to the ZC2HC1 family.

9615:APTX
gene id: 9615:APTX
uniprot id: P61797
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
messages: Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT/PARP1 and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated).
messages: The C2H2-type zinc finger mediates DNA-binding.
messages: The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4.
messages: The HIT domain is required for enzymatic activity.
messages: The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.
messages: nucleolus
messages: nucleoplasm

9615:ERGIC2
gene id: 9615:ERGIC2
uniprot id: A0A8C0T1G9
uniprot id: A0A8P0TQI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9615:SART3
gene id: 9615:SART3
uniprot id: A0A8I3PXC8
names: Subcellular Location Annotation
messages: nucleoplasm

9615:PSMD7
gene id: 9615:PSMD7
uniprot id: A0A8C0T8B3
uniprot id: A0A8I3N9G3
names: Similarity
messages: Belongs to the peptidase M67A family.

9615:SLC35E4
gene id: 9615:SLC35E4
uniprot id: A0A8C0TIR2
names: Subcellular Location Annotation
messages: Membrane

9615:CPLX1
gene id: 9615:CPLX1
uniprot id: A0A8C0QCI7
uniprot id: A0A8P0TQK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9615:FOLH1B
gene id: 9615:FOLH1B
uniprot id: I4IY07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9615:ME2
gene id: 9615:ME2
uniprot id: A0A8C0SEL5
uniprot id: A0A8I3MHQ2
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9615:KCNK4
gene id: 9615:KCNK4
uniprot id: A0A8C0N972
uniprot id: A0A8I3Q3Z0
uniprot id: A0A8I3QSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9615:CTF1
gene id: 9615:CTF1
uniprot id: A0A8C0SEM9
uniprot id: A0A8I3RZV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9615:PTGES
gene id: 9615:PTGES
uniprot id: A0SYQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAPEG family.
messages: Homotrimer.
messages: Membrane
messages: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
messages: perinuclear region

9615:LOC477508
gene id: 9615:LOC477508
uniprot id: A0A8C0PKK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9615:HSP90B1
gene id: 9615:HSP90B1
uniprot id: P41148
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heat shock protein 90 family.
messages: Detected in heart muscle (at protein level).
messages: Endoplasmic reticulum lumen
messages: Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9 (By similarity). Interacts with CNPY3; this interaction is disrupted in the presence of ATP. Interacts with several TLRs, including TLR4 and TLR9, but not with TLR3 (By similarity). Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23 (By similarity). Interacts with IL1B; the interaction facilitates cargo translocation into the ERGIC (By similarity).
messages: Melanosome
messages: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity (PubMed:17936703). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity).
messages: Phosphorylated by CK2.
messages: Sarcoplasmic reticulum lumen

9615:DISP3
gene id: 9615:DISP3
uniprot id: A0A8I3RS74
names: Subcellular Location Annotation
messages: Membrane

9615:SPPL2C
gene id: 9615:SPPL2C
uniprot id: A0A8C0S9J8
uniprot id: A0A8P0NFL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9615:G6PC3
gene id: 9615:G6PC3
uniprot id: A0A8C0T0Z4
uniprot id: A0A8I3ND17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9615:SCN2A
gene id: 9615:SCN2A
uniprot id: A0A8C0TTQ7
uniprot id: A0A8I3NWP9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9615:TRIT1
gene id: 9615:TRIT1
uniprot id: A0A8C0SMN1
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9615:CYP2W1
gene id: 9615:CYP2W1
uniprot id: A0A8P0NDQ1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9615:NDUFB2
gene id: 9615:NDUFB2
uniprot id: A0A8C0MHW9
uniprot id: A0A8I3Q8I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9615:TMEM121
gene id: 9615:TMEM121
uniprot id: A0A8I3S285
names: Similarity
messages: Belongs to the TMEM121 family.

9615:AP1S2
gene id: 9615:AP1S2
uniprot id: A0A8C0MK23
uniprot id: A0A8C0SIZ2
uniprot id: A0A8C0SKE4
uniprot id: A0A8I3Q5A5
uniprot id: A0A8I3QAU5
uniprot id: A0A8I3QZ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9615:THRSP
gene id: 9615:THRSP
uniprot id: A0A8C0YXJ3
uniprot id: A0A8I3N8C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9615:CPVL
gene id: 9615:CPVL
uniprot id: A0A8I3P2V6
names: Similarity
messages: Belongs to the peptidase S10 family.

9615:SH3BP5
gene id: 9615:SH3BP5
uniprot id: A0A8I3PXG6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9615:DCTN2
gene id: 9615:DCTN2
uniprot id: A0A8C0MVC7
uniprot id: A0A8C0SNF5
uniprot id: A0A8I3NKR5
uniprot id: A0A8I3RWZ8
names: Function
names: Similarity
messages: Belongs to the dynactin subunit 2 family.
messages: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

9615:GOSR1
gene id: 9615:GOSR1
uniprot id: A0A8C0MKX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9615:FASLG
gene id: 9615:FASLG
uniprot id: F1P7Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9615:OTULINL
gene id: 9615:OTULINL
uniprot id: A0A8C0T8J3
uniprot id: A0A8C0Z2L6
uniprot id: A0A8P0NB88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9615:NLK
gene id: 9615:NLK
uniprot id: E2QWQ2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by the non-canonical Wnt signaling pathway, in which WNT5A leads to activation of MAP3K7/TAK1 and HIPK2, which subsequently phosphorylates and activates this protein. Activated by dimerization and subsequent intermolecular autophosphorylation on Thr-298. Other cytokines such as IL6 may also activate this regulatory circuit (By similarity).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. This mode of activation contrasts with that of classical MAP kinases, which contain a TXY activation loop motif in which phosphorylation of both the threonine and tyrosine residues is required for kinase activation (By similarity).
messages: Cytoplasm
messages: Homodimer. Homodimerization is required for intermolecular autophosphorylation, kinase activation and nuclear localization (By similarity). May interact with components of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes (By similarity). Interacts with LEF1, MEF2A, MYBL1 and MYBL2 (By similarity). Interacts with the upstream activating kinases HIPK2 and MAP3K7/TAK1. Interaction with MAP3K7/TAK1 seems to be indirect, and may be mediated by other proteins such as STAT3, TAB1 and TAB2. Interacts with and phosphorylates a number of transcription factors including FOXO1, FOXO3, FOXO4, MYB, NOTCH1 and TCF7L2/TCF4. Interacts with DAPK3/ZIPK, and this interaction may disrupt interaction with transcription factors such as TCF7L2/TCF4. Forms a transcriptional repressor complex with CHD7, PPARG and SETDB1. Interacts with RNF138/NARF (By similarity). Interacts with ATF5; the interaction stabilizes ATF5 at the protein level in a kinase-independent manner (By similarity).
messages: Nucleus
messages: Phosphorylated on Thr-298. Intermolecular autophosphorylation on Thr-298 activates the enzyme (By similarity).
messages: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner.

9615:FOXJ1
gene id: 9615:FOXJ1
uniprot id: A0A8C0PRJ7
uniprot id: A0A8I3P9M6
names: Subcellular Location Annotation
messages: Nucleus

9615:CES5A
gene id: 9615:CES5A
uniprot id: Q6AW47
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
messages: N-glycosylated.
messages: Secreted

9615:NFYB
gene id: 9615:NFYB
uniprot id: A0A8C0TL47
uniprot id: A0A8I3NCQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9615:EYA1
gene id: 9615:EYA1
uniprot id: A0A8C0RFH1
uniprot id: A0A8C0TL92
uniprot id: A0A8C0TNQ1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9615:ABRAXAS2
gene id: 9615:ABRAXAS2
uniprot id: A0A8C0Z383
names: Subcellular Location Annotation
messages: Nucleus

9615:SMAD6
gene id: 9615:SMAD6
uniprot id: A0A8C0N7T6
uniprot id: A0A8I3P2D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9615:DNM2
gene id: 9615:DNM2
uniprot id: A0A8C0P214
uniprot id: A0A8C0SYL7
uniprot id: A0A8C0SZZ4
uniprot id: A0A8C0T2P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

9615:PRLR
gene id: 9615:PRLR
uniprot id: A0A8C0S6N3
uniprot id: A0A8I3MFS4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9615:FADS6
gene id: 9615:FADS6
uniprot id: A0A8I3NQZ1
names: Similarity
messages: Belongs to the fatty acid desaturase type 1 family.

9615:LOC100685611
gene id: 9615:LOC100685611
uniprot id: A0A8C0S4Y9
uniprot id: J9NZS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9615:HIRA
gene id: 9615:HIRA
uniprot id: A0A8C0SWZ2
uniprot id: A0A8C0T033
uniprot id: A0A8I3Q452
uniprot id: A0A8I3QW82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9615:SPACA5
gene id: 9615:SPACA5
uniprot id: A0A8C0N7J5
uniprot id: A0A8C0N7Z1
uniprot id: A0A8I3Q796
uniprot id: A0A8I3QP58
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9615:DLG2
gene id: 9615:DLG2
uniprot id: A0A8C0MP26
uniprot id: A0A8I3N790
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane

9615:CLDN9
gene id: 9615:CLDN9
uniprot id: A0A8C0Z1H0
uniprot id: A0A8I3MQH4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:TMEM256
gene id: 9615:TMEM256
uniprot id: A0A8C0QET2
uniprot id: A0A8I3PIS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9615:GHSR
gene id: 9615:GHSR
uniprot id: A0A8C0SMI6
uniprot id: A5HKU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

9615:NMI
gene id: 9615:NMI
uniprot id: A0A8C0N989
uniprot id: A0A8I3RW19
uniprot id: A0A8P0NZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9615:RRAD
gene id: 9615:RRAD
uniprot id: A0A8C0MYW7
uniprot id: A0A8I3NBE9
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9615:UBR2
gene id: 9615:UBR2
uniprot id: A0A8C0Q8P2
uniprot id: A0A8C0Q935
uniprot id: A0A8I3MZJ1
uniprot id: A0A8I3RSY5
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9615:ARRDC3
gene id: 9615:ARRDC3
uniprot id: A0A8C0Q1M7
uniprot id: A0A8I3NN54
names: Similarity
messages: Belongs to the arrestin family.

9615:PSMG1
gene id: 9615:PSMG1
uniprot id: A0A8C0PVZ6
uniprot id: A0A8I3PZN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9615:OR4D5
gene id: 9615:OR4D5
uniprot id: A0A8P0SQ27
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:GLB1
gene id: 9615:GLB1
uniprot id: Q9TRY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 35 family.
messages: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
messages: Homodimer. May form higher multimers.
messages: Lysosome

9615:COPE
gene id: 9615:COPE
uniprot id: A0A8C0N9X2
uniprot id: A0A8I3NYM1
uniprot id: A0A8I3NZ27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9615:MLH3
gene id: 9615:MLH3
uniprot id: A0A8C0SJ31
uniprot id: A0A8P0SL21
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9615:PELI1
gene id: 9615:PELI1
uniprot id: A0A8C0NJ22
uniprot id: A0A8I3PJH9
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9615:LTF
gene id: 9615:LTF
uniprot id: A0A8I3NMR3
names: Similarity
messages: Belongs to the transferrin family.

9615:ALDH6A1
gene id: 9615:ALDH6A1
uniprot id: A0A8C0S7D1
uniprot id: A0A8I3NRV2
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9615:MED18
gene id: 9615:MED18
uniprot id: A0A8C0Q308
uniprot id: A0A8I3N4Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9615:CDC42BPB
gene id: 9615:CDC42BPB
uniprot id: A0A8P0P7L3
uniprot id: A0A8P0P9Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9615:PDE4A
gene id: 9615:PDE4A
uniprot id: A0A8C0NVP8
uniprot id: A0A8C0NXX5
uniprot id: A0A8C0P196
uniprot id: A0A8I3PRR5
uniprot id: A0A8I3PTU7
uniprot id: A0A8I3SAJ6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:THOC6
gene id: 9615:THOC6
uniprot id: A0A8C0RB54
uniprot id: A0A8I3MPA7
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9615:DPF2
gene id: 9615:DPF2
uniprot id: A0A8C0T5U5
names: Similarity
messages: Belongs to the requiem/DPF family.

9615:PELI3
gene id: 9615:PELI3
uniprot id: A0A8C0SF51
uniprot id: A0A8I3NZQ5
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9615:PROC
gene id: 9615:PROC
uniprot id: Q28278
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin-thrombomodulin complex.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Plasma; synthesized in the liver.
messages: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
messages: Secreted
messages: Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin (By similarity).
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
messages: The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.

9615:HSF1
gene id: 9615:HSF1
uniprot id: A0A8C0PQM1
uniprot id: A0A8C0T1S8
uniprot id: A0A8I3NE22
uniprot id: A0A8I3NNB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9615:SSR3
gene id: 9615:SSR3
uniprot id: A0A8C0T6I4
uniprot id: A0A8P0SDY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9615:CALCA
gene id: 9615:CALCA
uniprot id: P41547
uniprot id: Q9MYV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calcitonin family.
messages: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity).
messages: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
messages: Secreted
messages: Synthesized by C-cells of the thyroid gland.

9615:DGKE
gene id: 9615:DGKE
uniprot id: A0A8C0MX95
uniprot id: A0A8I3PA16
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9615:ADGRE3
gene id: 9615:ADGRE3
uniprot id: A0A8C0Z0D4
uniprot id: Q2Q420
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SULT1A1
gene id: 9615:SULT1A1
uniprot id: Q29476
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Homodimer.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe (PubMed:12054462). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (By similarity). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
messages: Ubiquitously expressed in canine tissues with highest expression in male and female liver.

9615:RPP30
gene id: 9615:RPP30
uniprot id: A0A8C0NI19
uniprot id: A0A8I3Q0S9
uniprot id: A0A8I3Q6M5
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9615:CENPM
gene id: 9615:CENPM
uniprot id: A0A8C0ST46
uniprot id: A0A8I3P5M5
names: Subcellular Location Annotation
messages: Nucleus

9615:ADGRG1
gene id: 9615:ADGRG1
uniprot id: A0A8I3MPQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9615:GPC6
gene id: 9615:GPC6
uniprot id: A0A8C0QGN7
uniprot id: A0A8I3N3M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9615:CCL26
gene id: 9615:CCL26
uniprot id: Q64H35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils. Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis.
messages: Monomer.
messages: Secreted

9615:GABRA3
gene id: 9615:GABRA3
uniprot id: A0A8C0SP42
uniprot id: A0A8P0T7Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9615:NSG2
gene id: 9615:NSG2
uniprot id: A0A8C0Z1S9
uniprot id: A0A8I3MHX1
names: Similarity
messages: Belongs to the NSG family.

9615:TMX2
gene id: 9615:TMX2
uniprot id: A0A8C0MGF9
uniprot id: A0A8I3S4C8
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9615:SMARCA2
gene id: 9615:SMARCA2
uniprot id: A0A8C0Q810
uniprot id: A0A8I3RQI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9615:CPT2
gene id: 9615:CPT2
uniprot id: A0A8C0RCF5
uniprot id: A0A8I3NSG5
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9615:CLEC16A
gene id: 9615:CLEC16A
uniprot id: A0A8C0QH60
uniprot id: A0A8I3RXC4
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9615:MFAP1
gene id: 9615:MFAP1
uniprot id: A0A8C0Z325
uniprot id: A0A8I3PWP2
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9615:RALB
gene id: 9615:RALB
uniprot id: A0A8C0RR06
uniprot id: A0A8I3S667
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9615:AKAP3
gene id: 9615:AKAP3
uniprot id: A0A8C0TNW3
names: Similarity
messages: Belongs to the AKAP110 family.

9615:PGAM2
gene id: 9615:PGAM2
uniprot id: A0A8C0TNC0
uniprot id: A0A8I3NE41
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9615:ADGRE2
gene id: 9615:ADGRE2
uniprot id: Q2Q421
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Binding to chondroitin sulfate is mediated by the fourth EGF domain.
messages: Cell membrane
messages: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins.
messages: Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55.
messages: The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.
messages: ruffle membrane

9615:LSM1
gene id: 9615:LSM1
uniprot id: A0A8C0S6Z1
uniprot id: A0A8I3NF08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9615:SMUG1
gene id: 9615:SMUG1
uniprot id: A0A8P0SBY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9615:SERPINA9
gene id: 9615:SERPINA9
uniprot id: A0A8C0Q110
uniprot id: A0A8P0NJ89
names: Similarity
messages: Belongs to the serpin family.

9615:HS3ST3A1
gene id: 9615:HS3ST3A1
uniprot id: A0A8C0TAA7
uniprot id: A0A8P0NIZ1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9615:FZD4
gene id: 9615:FZD4
uniprot id: A0A8I3RTD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9615:EIF4EBP3
gene id: 9615:EIF4EBP3
uniprot id: A0A8C0M9J6
uniprot id: A0A8I3RRN9
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9615:LEF1
gene id: 9615:LEF1
uniprot id: A0A8C0Z3U9
uniprot id: A0A8I3Q609
uniprot id: A0A8P0NWB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9615:CLCF1
gene id: 9615:CLCF1
uniprot id: A0A8P0SGH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9615:GCN1
gene id: 9615:GCN1
uniprot id: A0A8C0T2J9
uniprot id: A0A8P0SF72
names: Similarity
messages: Belongs to the GCN1 family.

9615:SLC35C1
gene id: 9615:SLC35C1
uniprot id: A0A8I3Q1E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

9615:LCK
gene id: 9615:LCK
uniprot id: A0A8C0TE05
uniprot id: A0A8I3NAC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9615:SOX14
gene id: 9615:SOX14
uniprot id: A0A8C0N4V0
uniprot id: A0A8I3PHG7
names: Subcellular Location Annotation
messages: Nucleus

9615:NDUFAF2
gene id: 9615:NDUFAF2
uniprot id: A0A8C0LW13
uniprot id: A0A8I3N1H0
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9615:PLSCR5
gene id: 9615:PLSCR5
uniprot id: A0A8C0MH02
uniprot id: A0A8I3PN12
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9615:INHBC
gene id: 9615:INHBC
uniprot id: A0A8I3N9C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9615:PPP1R2
gene id: 9615:PPP1R2
uniprot id: A0A8C0TYC8
uniprot id: A0A8I3QAG8
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9615:RRP1
gene id: 9615:RRP1
uniprot id: A0A8C0SI49
uniprot id: A0A8P0NCY4
names: Similarity
messages: Belongs to the RRP1 family.

9615:ADD1
gene id: 9615:ADD1
uniprot id: A0A8P0NZE9
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9615:ZFPL1
gene id: 9615:ZFPL1
uniprot id: A0A8C0MSY3
uniprot id: A0A8I3PUT7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

9615:EEF2K
gene id: 9615:EEF2K
uniprot id: A0A8C0RMY7
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9615:IRF6
gene id: 9615:IRF6
uniprot id: A0A8C0T0U5
uniprot id: A0A8I3MM71
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9615:SSR2
gene id: 9615:SSR2
uniprot id: P23438
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with STING1 (By similarity).
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9615:TM2D1
gene id: 9615:TM2D1
uniprot id: A0A8C0LUR4
names: Subcellular Location Annotation
messages: Membrane

9615:SPA17
gene id: 9615:SPA17
uniprot id: A0A8C0R964
uniprot id: A0A8I3NGJ9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9615:CTBS
gene id: 9615:CTBS
uniprot id: A0A8C0NAM9
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

9615:IL5
gene id: 9615:IL5
uniprot id: Q95J76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).
messages: Secreted

9615:VPS8
gene id: 9615:VPS8
uniprot id: A0A8C0TVB9
uniprot id: A0A8I3Q365
names: Similarity
messages: Belongs to the VPS8 family.

9615:CKS2
gene id: 9615:CKS2
uniprot id: A0A8C0RUI1
uniprot id: A0A8I3P0I1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9615:PREB
gene id: 9615:PREB
uniprot id: A0A8C0MJ77
uniprot id: A0A8I3MY57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9615:LRWD1
gene id: 9615:LRWD1
uniprot id: A0A8P0SII1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRWD1 family.
messages: centrosome
messages: kinetochore
messages: telomere

9615:POLR1C
gene id: 9615:POLR1C
uniprot id: A0A8C0QML3
uniprot id: A0A8I3RVA8
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9615:VPS35
gene id: 9615:VPS35
uniprot id: A0A8C0NC57
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9615:CANT1
gene id: 9615:CANT1
uniprot id: A0A8C0PWZ5
uniprot id: A0A8C0RBN6
uniprot id: A0A8C0RWU9
uniprot id: A0A8I3NVL3
uniprot id: A0A8P0T8G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apyrase family.
messages: Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
messages: extracellular matrix

9615:TRAF6
gene id: 9615:TRAF6
uniprot id: A0A8C0SJC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9615:HSD17B7
gene id: 9615:HSD17B7
uniprot id: A0A8C0S4I9
uniprot id: A0A8I3SA02
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9615:ADGRE5
gene id: 9615:ADGRE5
uniprot id: Q2Q423
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:SFRP2
gene id: 9615:SFRP2
uniprot id: Q863H1
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
messages: The FZ domain is involved in binding with Wnt ligands.
messages: Up-regulated in mammary gland tumors.

9615:CDC25A
gene id: 9615:CDC25A
uniprot id: A0A8C0TR13
uniprot id: A0A8I3RVA5
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9615:RNASEH2A
gene id: 9615:RNASEH2A
uniprot id: A0A8C0P7K1
uniprot id: A0A8I3NML4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9615:RAB4A
gene id: 9615:RAB4A
uniprot id: A0A8C0Q6A6
uniprot id: A0A8I3ML15
uniprot id: A0A8P0TPH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9615:GRIN2B
gene id: 9615:GRIN2B
uniprot id: Q5R1P3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily.
messages: Cell membrane
messages: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).
messages: Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), at least one epsilon subunit, plus GRIN3A or GRIN3B. In vivo, the subunit composition may depend on the expression levels of the different subunits. Found in a complex with GRIN1, GRIN3A and PPP2CB. Found in a complex with GRIN1 and GRIN3B. Interacts with MAGI3. Interacts with HIP1 and Neto1. Interacts with PDZ domains of PATJ, DLG3 and DLG4. Interacts with DAPK1 (By similarity). Found in a complex with GRIN1 and PRR7. Interacts with PRR7 (By similarity). Interacts with CAMK2A (By similarity). Interacts with ARC; preventing ARC oligomerization (By similarity). Interacts with TMEM25 (By similarity).
messages: Late endosome
messages: Lysosome
messages: Phosphorylated on tyrosine residues (By similarity). Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (By similarity).
messages: Postsynaptic cell membrane
messages: cytoskeleton

9615:GRAMD1A
gene id: 9615:GRAMD1A
uniprot id: A0A8C0Q3Q2
uniprot id: A0A8I3MS15
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:TMEM41A
gene id: 9615:TMEM41A
uniprot id: A0A8C0RF25
uniprot id: A0A8I3Q2Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9615:NT5DC3
gene id: 9615:NT5DC3
uniprot id: A0A8P0N9Q7
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

9615:UFM1
gene id: 9615:UFM1
uniprot id: A0A8I3PN19
uniprot id: A0A8I3S9Y2
names: Similarity
messages: Belongs to the UFM1 family.

9615:STX6
gene id: 9615:STX6
uniprot id: A0A8C0PVR0
uniprot id: A0A8I3MH17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9615:LAPTM5
gene id: 9615:LAPTM5
uniprot id: A0A8C0MCN8
uniprot id: A0A8I3RVC2
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9615:SRP19
gene id: 9615:SRP19
uniprot id: A0A8C0NFD3
uniprot id: J9PAS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with IPO5, IPO7, IPO8, KPNB1 and TNPO1. Interactions with IPO8 and TNPO1 may be involved in SRP19 import into the nucleus (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6938958, PubMed:6413076). Binds directly to 7SL RNA (PubMed:6413076). Mediates binding of SRP54 to the SRP complex (PubMed:6413076).
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9615:TMEM198
gene id: 9615:TMEM198
uniprot id: A0A8C0RJ22
uniprot id: A0A8I3QBJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9615:LOC100686431
gene id: 9615:LOC100686431
uniprot id: A0A8C0QEF0
uniprot id: A0A8I3MAC3
names: Subcellular Location Annotation
messages: Nucleus

9615:MON1B
gene id: 9615:MON1B
uniprot id: A0A8C0RAN5
uniprot id: A0A8I3PG81
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9615:SPECC1L
gene id: 9615:SPECC1L
uniprot id: Q2KNA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9615:ATP6V1D
gene id: 9615:ATP6V1D
uniprot id: A0A8C0RM02
uniprot id: A0A8I3MUZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9615:GNPAT
gene id: 9615:GNPAT
uniprot id: A0A8C0NIX2
uniprot id: A0A8I3MC36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9615:HOXC5
gene id: 9615:HOXC5
uniprot id: A0A8C0NPX4
uniprot id: A0A8I3PAE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9615:COX15
gene id: 9615:COX15
uniprot id: A0A8C0RNU1
uniprot id: A0A8I3Q7W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9615:H2AW
gene id: 9615:H2AW
uniprot id: A0A8C0QMK5
uniprot id: A0A8I3N3A0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9615:FXYD6
gene id: 9615:FXYD6
uniprot id: A0A8C0PQW8
names: Similarity
messages: Belongs to the FXYD family.

9615:ARPC1A
gene id: 9615:ARPC1A
uniprot id: A0A8C0NSU7
uniprot id: A0A8I3MPK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9615:CHL1
gene id: 9615:CHL1
uniprot id: A0A8P0TJ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9615:PEAR1
gene id: 9615:PEAR1
uniprot id: A0A8P0T2J6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:TMEM150C
gene id: 9615:TMEM150C
uniprot id: A0A8I3NY10
names: Subcellular Location Annotation
messages: Membrane

9615:XPO7
gene id: 9615:XPO7
uniprot id: A0A8C0PGD4
uniprot id: A0A8C0TNI1
uniprot id: A0A8I3Q5B5
uniprot id: A0A8P0NC28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9615:APOOL
gene id: 9615:APOOL
uniprot id: A0A8C0NT18
uniprot id: A0A8C0S5J6
uniprot id: A0A8I3PJ66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9615:LHFPL5
gene id: 9615:LHFPL5
uniprot id: A0A8C0SY14
uniprot id: A0A8I3NGC9
names: Subcellular Location Annotation
messages: Membrane

9615:LCMT1
gene id: 9615:LCMT1
uniprot id: A0A8C0PU74
uniprot id: A0A8C0RW18
uniprot id: A0A8I3MBM2
uniprot id: A0A8I3MCG7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9615:CHAF1B
gene id: 9615:CHAF1B
uniprot id: A0A8P0NBR1
names: Subcellular Location Annotation
messages: Nucleus

9615:ST6GALNAC1
gene id: 9615:ST6GALNAC1
uniprot id: Q00M93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9615:PPARGC1B
gene id: 9615:PPARGC1B
uniprot id: A0A8C0M2E3
uniprot id: A0A8I3N0I9
names: Subcellular Location Annotation
messages: Nucleus

9615:IMMT
gene id: 9615:IMMT
uniprot id: A0A8C0MLP9
uniprot id: A0A8C0MLV4
uniprot id: A0A8I3NEJ1
uniprot id: A0A8I3RXK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9615:ZC3H12C
gene id: 9615:ZC3H12C
uniprot id: A0A8C0S9N9
names: Similarity
messages: Belongs to the ZC3H12 family.

9615:MAGT1
gene id: 9615:MAGT1
uniprot id: A0A8C0SXS8
uniprot id: A0A8I3PBS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:AFG1L
gene id: 9615:AFG1L
uniprot id: A0A8C0S658
uniprot id: A0A8I3NDZ0
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9615:VCP
gene id: 9615:VCP
uniprot id: A0A8C0NHS9
uniprot id: A0A8I3N153
names: Similarity
messages: Belongs to the AAA ATPase family.

9615:MICOS10
gene id: 9615:MICOS10
uniprot id: A0A8C0MMN2
uniprot id: A0A8I3MPR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9615:ARL8B
gene id: 9615:ARL8B
uniprot id: A0A8C0MTI6
uniprot id: A0A8I3N7D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: spindle

9615:SNX31
gene id: 9615:SNX31
uniprot id: A0A8C0NRY5
uniprot id: A0A8C0NVH1
names: Similarity
messages: Belongs to the sorting nexin family.

9615:STX18
gene id: 9615:STX18
uniprot id: A0A8C0SPU6
uniprot id: A0A8C0SR93
uniprot id: A0A8I3ML77
uniprot id: A0A8I3N4G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9615:ADRA1B
gene id: 9615:ADRA1B
uniprot id: P11615
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.
messages: Nucleus membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
messages: caveola

9615:RHPN2
gene id: 9615:RHPN2
uniprot id: Q8HXG3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RHPN family.
messages: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity).
messages: By thyrotropin (TSH).
messages: Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. Interacts with KRT18 (By similarity).
messages: Mainly expressed in thyroid.
messages: perinuclear region

9615:IL18RAP
gene id: 9615:IL18RAP
uniprot id: A0A8I3RXV6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9615:KRTCAP2
gene id: 9615:KRTCAP2
uniprot id: P86229
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRTCAP2 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:15835887). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (Probable). Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex (By similarity).
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9615:TNP2
gene id: 9615:TNP2
uniprot id: O77645
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear transition protein 2 family.
messages: Chromosome
messages: Nucleus
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: Testis.
messages: nucleolus

9615:HNRNPUL1
gene id: 9615:HNRNPUL1
uniprot id: A0A8I3MTA2
names: Subcellular Location Annotation
messages: Nucleus

9615:PABIR2
gene id: 9615:PABIR2
uniprot id: A0A8C0TN80
uniprot id: A0A8I3Q6U4
names: Similarity
messages: Belongs to the FAM122 family.

9615:PSMB9
gene id: 9615:PSMB9
uniprot id: A0A8C0T7K4
uniprot id: Q5W412
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9615:APEH
gene id: 9615:APEH
uniprot id: A0A8P0TL45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

9615:PLP1
gene id: 9615:PLP1
uniprot id: P23294
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: Defects in PLP1 are the cause of 'shaking pup' disease; a dysmyelinating disease.
messages: Myelin membrane
messages: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

9615:KRT84
gene id: 9615:KRT84
uniprot id: A0A8C0T0G6
names: Similarity
messages: Belongs to the intermediate filament family.

9615:PDE7B
gene id: 9615:PDE7B
uniprot id: A0A8P0N3I7
uniprot id: A0A8P0PG76
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9615:ACKR3
gene id: 9615:ACKR3
uniprot id: P11613
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Cell membrane
messages: Early endosome
messages: Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2.
messages: Recycling endosome
messages: The C-terminal cytoplasmic tail, plays a key role in: correct trafficking to the cell membrane, recruitment of beta-arrestin, ubiquitination, and in chemokine scavenging and signaling functions. The Ser/Thr residues and the Lys residues in the C-terminal cytoplasmic tail are essential for beta-arrestin recruitment and ubiquitination respectively.
messages: The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
messages: Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner.

9615:TIMM17B
gene id: 9615:TIMM17B
uniprot id: A0A8C0MNG2
uniprot id: A0A8I3QW29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

9615:BARHL1
gene id: 9615:BARHL1
uniprot id: A0A8C0Q0X9
uniprot id: A0A8I3S2B4
names: Subcellular Location Annotation
messages: Nucleus

9615:AZGP1
gene id: 9615:AZGP1
uniprot id: A0A8C0Z0R3
uniprot id: A0A8I3RR08
names: Similarity
messages: Belongs to the MHC class I family.

9615:GADD45G
gene id: 9615:GADD45G
uniprot id: A0A8C0M775
uniprot id: A0A8I3P710
names: Similarity
messages: Belongs to the GADD45 family.

9615:DBR1
gene id: 9615:DBR1
uniprot id: A0A8C0N0N9
uniprot id: A0A8C0TNC6
uniprot id: A0A8I3PF34
uniprot id: A0A8I3PSP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

9615:NAPA
gene id: 9615:NAPA
uniprot id: A0A8C0MVQ9
uniprot id: A0A8I3MLQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9615:CHSY3
gene id: 9615:CHSY3
uniprot id: A0A8I3NHS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9615:RORC
gene id: 9615:RORC
uniprot id: A0A8C0MZK9
uniprot id: A0A8I3PTL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9615:DHRS9
gene id: 9615:DHRS9
uniprot id: A0A8C0P7Q2
uniprot id: A0A8I3PAT8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:LYRM9
gene id: 9615:LYRM9
uniprot id: A0A8C0NB24
uniprot id: A0A8I3NK00
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

9615:CLTC
gene id: 9615:CLTC
uniprot id: A0A8C0MFZ6
uniprot id: A0A8I3PQE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9615:MARCKSL1
gene id: 9615:MARCKSL1
uniprot id: A0A8C0TGC8
uniprot id: A0A8I3MTV8
names: Similarity
messages: Belongs to the MARCKS family.

9615:CYP1A2
gene id: 9615:CYP1A2
uniprot id: Q5R2U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9615:UBA2
gene id: 9615:UBA2
uniprot id: A0A8C0M2R3
uniprot id: A0A8C0QCG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

9615:XRCC1
gene id: 9615:XRCC1
uniprot id: A0A8C0SJ49
uniprot id: A0A8I3MFG7
names: Subcellular Location Annotation
messages: Nucleus

9615:LAMTOR4
gene id: 9615:LAMTOR4
uniprot id: A0A8C0YZX7
uniprot id: A0A8I3MTE0
names: Similarity
messages: Belongs to the LAMTOR4 family.

9615:TRNT1
gene id: 9615:TRNT1
uniprot id: A0A8C0Q7X7
uniprot id: A0A8I3NJ54
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9615:GHRH
gene id: 9615:GHRH
uniprot id: A0A8C0SWR7
uniprot id: A0A8I3PVA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9615:MARCO
gene id: 9615:MARCO
uniprot id: A0A8C0PB10
uniprot id: A0A8P0N7M1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:LHFPL6
gene id: 9615:LHFPL6
uniprot id: A0A8C0NSZ9
uniprot id: A0A8I3S4U0
names: Subcellular Location Annotation
messages: Membrane

9615:YARS2
gene id: 9615:YARS2
uniprot id: A0A8C0PGU0
uniprot id: A0A8I3NPB7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9615:ASXL1
gene id: 9615:ASXL1
uniprot id: A0A8P0PC91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9615:TLR7
gene id: 9615:TLR7
uniprot id: Q2L4T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane
messages: phagosome

9615:SLC25A33
gene id: 9615:SLC25A33
uniprot id: A0A8C0SJN3
uniprot id: A0A8I3PZW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9615:SLC17A9
gene id: 9615:SLC17A9
uniprot id: A0A8C0TKN2
uniprot id: A0A8I3PEG6
names: Subcellular Location Annotation
messages: Membrane

9615:PLA2G15
gene id: 9615:PLA2G15
uniprot id: Q6XPZ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:11790796). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:11790796). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (By similarity). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress. Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity).
messages: Lysosome
messages: Membrane
messages: N-glycosylated. N-glycosylation is important for maturation of the enzyme and normal subcellular location.
messages: Secreted

9615:EDNRA
gene id: 9615:EDNRA
uniprot id: Q5J7U3
uniprot id: Q5KSU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9615:GIMAP1
gene id: 9615:GIMAP1
uniprot id: A0A8P0SA76
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9615:NXPE3
gene id: 9615:NXPE3
uniprot id: A0A8P0SEJ9
names: Similarity
messages: Belongs to the NXPE family.

9615:LOC489397
gene id: 9615:LOC489397
uniprot id: A0A8I3MEX5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9615:CAMK1D
gene id: 9615:CAMK1D
uniprot id: A0A8C0PZT9
uniprot id: A0A8I3RQN8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:LOC612524
gene id: 9615:LOC612524
uniprot id: A0A8C0T4S2
uniprot id: A0A8I3QYS0
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.

9615:CEL
gene id: 9615:CEL
uniprot id: A0A8C0RP22
uniprot id: A0A8P0NL31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9615:CYCS
gene id: 9615:CYCS
uniprot id: P00011
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).

9615:ALLC
gene id: 9615:ALLC
uniprot id: A0A8C0RLR4
uniprot id: A0A8P0S8Z4
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9615:WASF3
gene id: 9615:WASF3
uniprot id: A0A8C0T7X7
uniprot id: A0A8I3PXN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9615:SLC1A5
gene id: 9615:SLC1A5
uniprot id: K7ZSN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9615:MACIR
gene id: 9615:MACIR
uniprot id: A0A8I3MX78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9615:MRPL40
gene id: 9615:MRPL40
uniprot id: A0A8P0PFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9615:DDB1
gene id: 9615:DDB1
uniprot id: A0A8C0QFD6
uniprot id: A0A8I3NKI4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9615:GMFG
gene id: 9615:GMFG
uniprot id: A0A8C0SLP7
uniprot id: A0A8C0SMU3
uniprot id: A0A8I3MUL5
uniprot id: A0A8I3MXF6
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9615:BAP1
gene id: 9615:BAP1
uniprot id: A0A8C0MP98
uniprot id: A0A8I3QAS2
names: Similarity
messages: Belongs to the peptidase C12 family.

9615:LOC487951
gene id: 9615:LOC487951
uniprot id: A0A8C0TMH2
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9615:MAP2K6
gene id: 9615:MAP2K6
uniprot id: A0A8C0M2T9
uniprot id: A0A8I3NBF5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9615:ACOD1
gene id: 9615:ACOD1
uniprot id: A0A8C0RF82
uniprot id: A0A8I3PS95
names: Similarity
messages: Belongs to the PrpD family.

9615:SNAP91
gene id: 9615:SNAP91
uniprot id: A0A8C0QPT1
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9615:TM6SF2
gene id: 9615:TM6SF2
uniprot id: A0A8C0Z3J3
uniprot id: A0A8I3S0Y9
names: Subcellular Location Annotation
messages: Membrane

9615:SEC24B
gene id: 9615:SEC24B
uniprot id: A0A8C0PFF1
uniprot id: A0A8C0RS65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9615:BDNF
gene id: 9615:BDNF
uniprot id: Q7YRB4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).
messages: Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).
messages: Monomers and homodimers (By similarity). Binds to NTRK2/TRKB. Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (By similarity). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower affinity for the heterodimer formed by NGFR and SORCS2 (By similarity).
messages: N-glycosylated and glycosulfated, contrary to mature BDNF.
messages: Secreted

9615:FGD5
gene id: 9615:FGD5
uniprot id: A0A8C0T1Q2
uniprot id: A0A8I3PW48
names: Subcellular Location Annotation
messages: cytoskeleton

9615:STXBP2
gene id: 9615:STXBP2
uniprot id: Q28288
names: Function
names: Similarity
names: Subunit
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Binds syntaxins 1A, 2, 3 but not 4.
messages: Involved in the protein trafficking from the Golgi apparatus to the plasma membrane.

9615:TRPM8
gene id: 9615:TRPM8
uniprot id: Q1A7N1
names: Subcellular Location Annotation
messages: Membrane

9615:COX4I1
gene id: 9615:COX4I1
uniprot id: A0A8C0NS51
uniprot id: A0A8I3MW16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9615:GNL2
gene id: 9615:GNL2
uniprot id: A0A8P0S994
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9615:OR10A3
gene id: 9615:OR10A3
uniprot id: A0A8C0Q844
uniprot id: A0A8I3NKH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:FAHD2A
gene id: 9615:FAHD2A
uniprot id: A0A8C0QRH7
uniprot id: A0A8I3N070
names: Similarity
messages: Belongs to the FAH family.

9615:OR55B1
gene id: 9615:OR55B1
uniprot id: E2RME2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:DUOXA1
gene id: 9615:DUOXA1
uniprot id: A0A8C0TN25
uniprot id: A0A8I3QCA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9615:SV2C
gene id: 9615:SV2C
uniprot id: A0A8C0MWS1
uniprot id: A0A8I3RYA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9615:LOC478702
gene id: 9615:LOC478702
uniprot id: A0A8I3P982
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9615:LOC106559663
gene id: 9615:LOC106559663
uniprot id: A0A8C0Z1U1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9615:RHBDF1
gene id: 9615:RHBDF1
uniprot id: A0A8I3MHV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

9615:OR56A3C
gene id: 9615:OR56A3C
uniprot id: A0A8I3N548
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:EIF1
gene id: 9615:EIF1
uniprot id: A0A8C0YUG5
uniprot id: A0A8I3NWE5
names: Similarity
messages: Belongs to the SUI1 family.

9615:CSTF1
gene id: 9615:CSTF1
uniprot id: A0A8C0PJK5
uniprot id: A0A8I3Q2Q2
names: Subcellular Location Annotation
messages: Nucleus

9615:SLC30A7
gene id: 9615:SLC30A7
uniprot id: A0A8C0PR71
uniprot id: A0A8I3NMF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9615:LOC479822
gene id: 9615:LOC479822
uniprot id: A0A8C0RUN3
uniprot id: A0A8P0NZE7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:RGS8
gene id: 9615:RGS8
uniprot id: A0A8C0M7I1
uniprot id: A0A8C0PV38
uniprot id: A0A8I3MPN0
uniprot id: A0A8I3RTE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: Perikaryon
messages: dendrite

9615:HMGN2
gene id: 9615:HMGN2
uniprot id: Q711A6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylation favors cytoplasmic localization.

9615:CMKLR1
gene id: 9615:CMKLR1
uniprot id: A0A8I3Q1X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9615:KCNC1
gene id: 9615:KCNC1
uniprot id: Q9XSJ8
names: Subcellular Location Annotation
messages: Membrane

9615:DKK3
gene id: 9615:DKK3
uniprot id: A0A8C0T1J9
uniprot id: W0RY37
names: Similarity
messages: Belongs to the dickkopf family.

9615:SEMA3G
gene id: 9615:SEMA3G
uniprot id: A0A8C0TE37
uniprot id: A0A8P0NBL9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:CLRN2
gene id: 9615:CLRN2
uniprot id: A0A8C0RBT4
uniprot id: A0A8I3MI40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9615:RDH12
gene id: 9615:RDH12
uniprot id: A0A8C0SDK6
uniprot id: A0A8I3MRK7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9615:ZDHHC24
gene id: 9615:ZDHHC24
uniprot id: A0A8C0NS22
uniprot id: A0A8I3NE70
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9615:AK1
gene id: 9615:AK1
uniprot id: A0A8C0N8N8
uniprot id: B4YY02
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9615:RGS1
gene id: 9615:RGS1
uniprot id: A0A8C0YW34
uniprot id: A0A8I3PM57
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

9615:TMEM170A
gene id: 9615:TMEM170A
uniprot id: A0A8C0M4B8
uniprot id: A0A8P0TI61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9615:DPYSL3
gene id: 9615:DPYSL3
uniprot id: A0A8C0M9S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
messages: growth cone

9615:OASL
gene id: 9615:OASL
uniprot id: Q2KM15
names: Similarity
messages: Belongs to the 2-5A synthase family.

9615:WASHC3
gene id: 9615:WASHC3
uniprot id: A0A8C0N532
uniprot id: A0A8I3N9Z9
names: Similarity
messages: Belongs to the CCDC53 family.

9615:ALDH1A2
gene id: 9615:ALDH1A2
uniprot id: A0A8C0TYR3
uniprot id: A0A8I3QC56
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9615:LOC100855676
gene id: 9615:LOC100855676
uniprot id: A0A8I3MAR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9615:FAM13C
gene id: 9615:FAM13C
uniprot id: A0A8C0PSM0
uniprot id: A0A8C0PXX6
uniprot id: A0A8I3MIE8
uniprot id: A0A8I3MLB4
names: Similarity
messages: Belongs to the FAM13 family.

9615:NSMCE1
gene id: 9615:NSMCE1
uniprot id: A0A8C0P8T4
uniprot id: A0A8I3N8D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9615:OR7G3
gene id: 9615:OR7G3
uniprot id: A0A8P0PDH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:LOC491264
gene id: 9615:LOC491264
uniprot id: A0A8P0SNI2
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Monomer.

9615:SMAD1
gene id: 9615:SMAD1
uniprot id: A0A8C0MGA9
uniprot id: A0A8I3NM89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9615:ADGRG5
gene id: 9615:ADGRG5
uniprot id: A0A8C0YUN4
uniprot id: A0A8I3MGY9
uniprot id: A0A8P0NAV5
names: Subcellular Location Annotation
messages: Membrane

9615:SEC61A1
gene id: 9615:SEC61A1
uniprot id: P38377
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).
messages: Endoplasmic reticulum membrane
messages: The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:10799540, PubMed:1423609). The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact (By similarity).

9615:AR
gene id: 9615:AR
uniprot id: Q9TT90
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with MACROD1 (via macro domain) (By similarity). Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 (via coiled coil domain). Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1. Interacts with CCAR1 and GATA2. Interacts with ZNF318. Interacts with BUD31. Interacts with ARID4A. Interacts with ARID4B. Interacts (via NR LBD domain) with ZBTB7A; the interaction is direct and androgen-dependent (By similarity). Interacts with NCOR1 (By similarity). Interacts with NCOR2 (By similarity). Interacts witH CRY2 in a ligand-dependent manner (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain (By similarity).
messages: Cytoplasm
messages: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
messages: Nucleus
messages: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).
messages: Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-522 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity). Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity. Phosphorylation at Ser-67 by CDK9 regulates AR promoter selectivity and cell growth (By similarity).
messages: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
messages: Sumoylated on Lys-389 (major) and Lys-508 (By similarity). Ubiquitinated. Deubiquitinated by USP26 (By similarity). 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity (By similarity).
messages: Transcriptional activity is enhanced by binding to RANBP9.

9615:CLN6
gene id: 9615:CLN6
uniprot id: Q5JZQ8
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Interacts with CRMP2. Interacts with CLN5 (By similarity). Interacts with CLN5. Interacts with CLN3 (By similarity).

9615:HSPD1
gene id: 9615:HSPD1
uniprot id: A0A8C0TC09
uniprot id: A0A8I3PXL2
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9615:TMC7
gene id: 9615:TMC7
uniprot id: A0A8P0SW67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9615:SLC27A6
gene id: 9615:SLC27A6
uniprot id: A0A8C0P495
uniprot id: A0A8I3N4Y3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9615:FUT11
gene id: 9615:FUT11
uniprot id: A0A8C0PRC0
uniprot id: A0A8I3RVW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9615:NUBP1
gene id: 9615:NUBP1
uniprot id: A0A8C0QFE4
uniprot id: A0A8I3NFS3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9615:URM1
gene id: 9615:URM1
uniprot id: A0A8C0N9X7
uniprot id: A0A8I3PZA2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9615:VEGFD
gene id: 9615:VEGFD
uniprot id: A0A8C0YXI0
uniprot id: A0A8I3SCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9615:TAF12
gene id: 9615:TAF12
uniprot id: A0A8C0SN31
uniprot id: E2QVZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9615:CD28
gene id: 9615:CD28
uniprot id: A0A8C0TU71
uniprot id: Q9GKP3
names: Subcellular Location Annotation
messages: Membrane

9615:TRPC1
gene id: 9615:TRPC1
uniprot id: A0A8C0MHJ0
uniprot id: A0A8C0MI41
uniprot id: A0A8C0RDN7
uniprot id: A0A8I3PYR3
uniprot id: A0A8I3Q281
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9615:ATP5F1D
gene id: 9615:ATP5F1D
uniprot id: A0A8C0QPC2
uniprot id: A0A8I3NCZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

9615:EVL
gene id: 9615:EVL
uniprot id: A0A8P0NJA8
uniprot id: A0A8P0NTU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: lamellipodium
messages: stress fiber

9615:SCRN3
gene id: 9615:SCRN3
uniprot id: A0A8C0NQ40
uniprot id: A0A8P0NEZ0
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9615:CCT4
gene id: 9615:CCT4
uniprot id: A0A8C0NST9
uniprot id: A0A8P0N621
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9615:SLC16A1
gene id: 9615:SLC16A1
uniprot id: A0A8I3MUJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9615:TTC3
gene id: 9615:TTC3
uniprot id: A0A8C0T874
uniprot id: A0A8I3S6L0
names: Subcellular Location Annotation
messages: Cytoplasm

9615:LZIC
gene id: 9615:LZIC
uniprot id: A0A8C0MI25
uniprot id: A0A8C0MM96
uniprot id: A0A8I3MAN6
uniprot id: A0A8P0PRR2
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9615:HAGHL
gene id: 9615:HAGHL
uniprot id: A0A8C0RJD9
uniprot id: A0A8I3PTN8
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9615:GLRA2
gene id: 9615:GLRA2
uniprot id: A0A8C0SDM5
uniprot id: A0A8I3QS28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9615:LUC7L
gene id: 9615:LUC7L
uniprot id: A0A8C0S882
uniprot id: A0A8C0S8H8
uniprot id: A0A8C0S8R0
uniprot id: A0A8I3MCT0
uniprot id: A0A8I3MCU8
uniprot id: A0A8I3RPN1
names: Similarity
messages: Belongs to the Luc7 family.

9615:NR5A2
gene id: 9615:NR5A2
uniprot id: A0A8C0S7V6
uniprot id: A0A8P0PBZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9615:LOC100856515
gene id: 9615:LOC100856515
uniprot id: A0A8C0PAN6
uniprot id: A0A8I3PVN3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9615:LOC482987
gene id: 9615:LOC482987
uniprot id: A0A8C0NJI1
uniprot id: A0A8I3PB58
names: Subcellular Location Annotation
messages: Membrane

9615:ARAP3
gene id: 9615:ARAP3
uniprot id: A0A8C0Q6C9
uniprot id: A0A8C0QCG5
names: Subcellular Location Annotation
messages: Cytoplasm

9615:EOGT
gene id: 9615:EOGT
uniprot id: Q5NDL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
messages: Endoplasmic reticulum lumen

9615:BASP1
gene id: 9615:BASP1
uniprot id: A0A8C0YYN1
names: Similarity
messages: Belongs to the BASP1 family.

9615:DYNLL2
gene id: 9615:DYNLL2
uniprot id: A0A8C0Z7L6
uniprot id: A0A8I3P2D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9615:ARRB1
gene id: 9615:ARRB1
uniprot id: A0A8I3NJZ9
names: Similarity
messages: Belongs to the arrestin family.

9615:FLAD1
gene id: 9615:FLAD1
uniprot id: A0A8C0PMT6
uniprot id: A0A8I3P1H5
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9615:CLDN6
gene id: 9615:CLDN6
uniprot id: A0A8C0RB18
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9615:SEPTIN7
gene id: 9615:SEPTIN7
uniprot id: A0A8I3Q1M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium axoneme
messages: flagellum
messages: kinetochore
messages: spindle

9615:RARB
gene id: 9615:RARB
uniprot id: A0A8C0PKW1
uniprot id: A0A8I3PGE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:AIP
gene id: 9615:AIP
uniprot id: A0A8C0S8A4
uniprot id: A0A8I3NBQ7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
messages: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

9615:NUDT5
gene id: 9615:NUDT5
uniprot id: A0A8C0NM54
uniprot id: A0A8I3MAJ3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9615:MAPK10
gene id: 9615:MAPK10
uniprot id: A0A8C0MYT2
uniprot id: A0A8C0TWL4
uniprot id: A0A8I3S3W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9615:SELP
gene id: 9615:SELP
uniprot id: A0A8C0Q3D2
uniprot id: A0A8I3MKI2
uniprot id: Q28290
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9615:MACROH2A1
gene id: 9615:MACROH2A1
uniprot id: A0A8C0S4U0
uniprot id: A0A8P0N4A7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9615:CSMD3
gene id: 9615:CSMD3
uniprot id: A0A8C0SMF3
uniprot id: A0A8I3NU12
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9615:MRGPRG
gene id: 9615:MRGPRG
uniprot id: A0A8C0PFZ2
uniprot id: F1PPU1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9615:RGS5
gene id: 9615:RGS5
uniprot id: A0A8C0P6I1
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9615:GABARAPL1
gene id: 9615:GABARAPL1
uniprot id: A0A8C0NRR5
uniprot id: A0A8I3PYF3
names: Similarity
messages: Belongs to the ATG8 family.

9615:STMN1
gene id: 9615:STMN1
uniprot id: A0A8C0NG77
uniprot id: A0A8I3NR64
uniprot id: A0A8I3P045
names: Similarity
messages: Belongs to the stathmin family.

9615:HDAC5
gene id: 9615:HDAC5
uniprot id: A0A8C0RBA0
uniprot id: A0A8I3RV81
uniprot id: A0A8I3RV93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9615:MFSD8
gene id: 9615:MFSD8
uniprot id: A0A8C0S8U7
uniprot id: A0A8I3PTN1
names: Subcellular Location Annotation
messages: Membrane

9615:FGD3
gene id: 9615:FGD3
uniprot id: A0A8C0PUA5
uniprot id: A0A8I3PKM6
names: Subcellular Location Annotation
messages: cytoskeleton

9615:FLVCR1
gene id: 9615:FLVCR1
uniprot id: A0A8I3MHS3
names: Subcellular Location Annotation
messages: Membrane

9615:RPL7L1
gene id: 9615:RPL7L1
uniprot id: A0A8C0RZC7
uniprot id: A0A8I3N6D0
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9615:ESRRG
gene id: 9615:ESRRG
uniprot id: A0A8C0PB38
uniprot id: A0A8I3PTN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9615:P4HA3
gene id: 9615:P4HA3
uniprot id: A0A8C0T2Z9
uniprot id: A0A8I3MSQ5
uniprot id: A0A8I3N373
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9615:PIGF
gene id: 9615:PIGF
uniprot id: A0A8C0S322
uniprot id: A0A8I3PUP6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:TOM1L2
gene id: 9615:TOM1L2
uniprot id: A0A8I3PBZ7
uniprot id: A0A8I3PD20
uniprot id: A0A8I3PG25
names: Similarity
messages: Belongs to the TOM1 family.

9615:FA2H
gene id: 9615:FA2H
uniprot id: A0A8C0M5Z8
uniprot id: A0A8I3PM33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

9615:KITLG
gene id: 9615:KITLG
uniprot id: Q06220
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form is produced by proteolytic processing of the extracellular domain.
messages: Acts in the early stages of hematopoiesis.
messages: Belongs to the SCF family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Secreted
messages: Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9615:HSPA14
gene id: 9615:HSPA14
uniprot id: A0A8C0Q3K4
uniprot id: A0A8I3RYL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9615:RPL30
gene id: 9615:RPL30
uniprot id: A0A8C0RLZ2
uniprot id: A0A8I3PLI7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9615:SPRY1
gene id: 9615:SPRY1
uniprot id: A0A8C0SDE6
uniprot id: A0A8I3P913
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

9615:TMEM251
gene id: 9615:TMEM251
uniprot id: A0A8I3NR99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM251 family.
messages: Membrane

9615:CHSY1
gene id: 9615:CHSY1
uniprot id: A0A8C0M2I7
uniprot id: A0A8I3MD46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9615:ALG2
gene id: 9615:ALG2
uniprot id: A0A8C0T6X6
uniprot id: A0A8I3N4U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

9615:HADHA
gene id: 9615:HADHA
uniprot id: A0A8C0RD03
uniprot id: A0A8I3PUE4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9615:NR1D2
gene id: 9615:NR1D2
uniprot id: A0A8C0P4D9
uniprot id: A0A8I3PFC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9615:CDADC1
gene id: 9615:CDADC1
uniprot id: A0A8C0S5U7
uniprot id: A0A8I3PLW5
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9615:CYP7A1
gene id: 9615:CYP7A1
uniprot id: A0A8C0SS44
uniprot id: A0A8I3PVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9615:PPT1
gene id: 9615:PPT1
uniprot id: A0A8C0P4T9
uniprot id: Q5JZR0
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9615:ADORA1
gene id: 9615:ADORA1
uniprot id: P11616
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9615:NFIB
gene id: 9615:NFIB
uniprot id: A0A8C0NAK7
uniprot id: A0A8C0RHQ2
uniprot id: A0A8C0YZN3
uniprot id: A0A8I3NGG1
uniprot id: A0A8I3RW85
uniprot id: A0A8P0T640
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9615:DDIT3
gene id: 9615:DDIT3
uniprot id: A0A8C0MS70
uniprot id: A0A8I3NHJ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9615:LNPK
gene id: 9615:LNPK
uniprot id: A0A8C0P047
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9615:GPR50
gene id: 9615:GPR50
uniprot id: A0A8C0SUJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9615:GCH1
gene id: 9615:GCH1
uniprot id: A0A8C0RBF0
uniprot id: A0A8I3NVH0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

9615:FOXB1
gene id: 9615:FOXB1
uniprot id: A0A8C0Z1U7
uniprot id: A0A8I3P1X5
names: Subcellular Location Annotation
messages: Nucleus

9615:SMDT1
gene id: 9615:SMDT1
uniprot id: A0A8C0RSL9
uniprot id: A0A8I3NVN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9615:OR52I1
gene id: 9615:OR52I1
uniprot id: G3FJF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9615:SLC12A4
gene id: 9615:SLC12A4
uniprot id: Q5KU49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9615:PTEN
gene id: 9615:PTEN
uniprot id: P60483
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. Tumor suppressor, the lipid phosphatase activity is critical for its tumor suppressor function (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, where…
messages: Belongs to the PTEN phosphatase protein family.
messages: Constitutively phosphorylated by CK2 under normal conditions. Phosphorylation results in an inhibited activity towards PIP3. Phosphorylation can both inhibit or promote PDZ-binding. Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation probably by inhibiting its binding to NEDD4 (By similarity). Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome. Phosphorylation by ROCK1 is essential for its stability and activity (By similarity).
messages: Cytoplasm
messages: Monomer. The unphosphorylated form interacts with the second PDZ domain of MAGI2 (By similarity). Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5; interaction with MAGI2 increases protein stability (By similarity). Interacts with NEDD4 (By similarity). Interacts with NDFIP1 and NDFIP2; in the presence of NEDD4 or ITCH, this interaction promotes PTEN ubiquitination (By similarity). Interacts (via C2 domain) with FRK (By similarity). Interacts with USP7; the interaction is direct (By similarity). Interacts with ROCK1. Interacts with XIAP/BIRC4 (By similarity). Interacts with STK11; the interaction phosphorylates PTEN (By similarity). Interacts with PPP1R16B (By similarity). Interacts with NOP53; regulates PTEN phosphorylation and increases its stability (By similarity). Interacts (via PDZ domain-binding motif) with DLG4; the interaction is induced by NMDA and is required for PTEN location at postsynaptic density (By similarity).
messages: Monoubiquitinated; monoubiquitination is increased in presence of retinoic acid. Deubiquitinated by USP7; leading to its nuclear exclusion. Monoubiquitination of one of either Lys-13 and Lys-289 amino acid is sufficient to modulate PTEN compartmentalization (By similarity). Ubiquitinated by XIAP/BIRC4 (By similarity).
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

9615:C26H12orf65
gene id: 9615:C26H12orf65
uniprot id: A0A8I3P696
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9615:MUL1
gene id: 9615:MUL1
uniprot id: A0A8C0QHV0
names: Subcellular Location Annotation
messages: Membrane

9615:GALNT12
gene id: 9615:GALNT12
uniprot id: A0A8C0NVD3
uniprot id: A0A8I3N0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9615:SOD1
gene id: 9615:SOD1
uniprot id: Q8WNN6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Nucleus
messages: Palmitoylation helps nuclear targeting and decreases catalytic activity.
messages: Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.

9615:EDN2
gene id: 9615:EDN2
uniprot id: P12064
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Endothelins are endothelium-derived vasoconstrictor peptides.
messages: Secreted

9615:MANEA
gene id: 9615:MANEA
uniprot id: A0A8C0RCY9
uniprot id: A0A8I3N4I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9615:MAB21L3
gene id: 9615:MAB21L3
uniprot id: A0A8C0SBK5
uniprot id: A0A8I3Q4Q5
names: Similarity
messages: Belongs to the mab-21 family.

9615:ASCC3
gene id: 9615:ASCC3
uniprot id: A0A8P0N6F9
names: Similarity
messages: Belongs to the helicase family.

9615:SAP30
gene id: 9615:SAP30
uniprot id: A0A8C0NXI2
uniprot id: A0A8I3P1N2
names: Similarity
messages: Belongs to the SAP30 family.

9615:RAB5C
gene id: 9615:RAB5C
uniprot id: P51147
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Early endosome membrane
messages: Interacts with EEA1 and INCA1 (By similarity). Interacts with GDI1, GDI2, CHML and CHM; phosphorylation at Ser-85 disrupts this interaction (By similarity).
messages: Melanosome
messages: Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Protein transport. Probably involved in vesicular traffic.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

9615:KCNN4
gene id: 9615:KCNN4
uniprot id: A0A8C0YXN7
uniprot id: A0A8I3N5F8
names: Subcellular Location Annotation
messages: Membrane

9615:APOC1
gene id: 9615:APOC1
uniprot id: P56595
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the apolipoprotein C1 family.
messages: Expressed in the liver.
messages: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
messages: Secreted

9615:GRIK5
gene id: 9615:GRIK5
uniprot id: A0A8C0QFS4
uniprot id: A0A8I3MJM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9615:ACTR5
gene id: 9615:ACTR5
uniprot id: A0A8I3Q254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP5 subfamily.
messages: Nucleus